CN108815468A

CN108815468A - A kind of Chinese medicine composition and preparation method thereof for treating painful swelling of joints

Info

Publication number: CN108815468A
Application number: CN201810935543.0A
Authority: CN
Inventors: 胡思元
Original assignee: Guizhou Miao Zhiyuan Miao Medicine Chinese Herbal Medicine Co Ltd
Current assignee: Guizhou Miao Zhiyuan Miao Medicine Chinese Herbal Medicine Co Ltd
Priority date: 2018-08-16
Filing date: 2018-08-16
Publication date: 2018-11-16

Abstract

The present invention relates to technical field of traditional Chinese medicines, a kind of specific Chinese medicine composition and preparation method thereof for treating painful swelling of joints, the present invention has selected the root of Chinese clematis, teasel root, rhizoma cibotii, radix paeoniae rubra, bletilla, Rhizoma Et Radix Notopterygii, aconiti preparata,radix, Cortex Eucommiae, leech, glutinous rehmannia, Semen Strychni (processed), Chinese ephedra, curcuma zedoary, Radix Angelicae Sinensis, safflower, rheum officinale, radix saposhnikoviae, Radix Glycyrrhizae, cortex cinnamomi, olibanum, myrrh, dragon's blood, Herba Epimedii, Rhizoma Chuanxiong, Paris polyphylla, camphor is combined, synergistic and attenuation is haved the function that, the heart can effectively be adjusted, lung, spleen, liver, kidney, gallbladder, bladder, the function of large intestine, with dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, detumescence ding-tong effect, suitable for traumatic injury, arthralgia and myalgia, rheumatic arthralgia, painful swelling of joints, osteoproliferation, the symptoms such as the protrusion of the intervertebral disc.

Description

A kind of Chinese medicine composition and preparation method thereof for treating painful swelling of joints

Technical field

The present invention relates to technical field of traditional Chinese medicines, a kind of specific Chinese medicine composition and preparation method thereof for treating painful swelling of joints.

Background technique

Painful swelling of joints is clinical common sympton, and usually by chill, many reasons such as wet, osteoproliferation, traumatic injury cause, Painful swelling of joints belongs to the natural damage and aging phenomenon of articular cartilage.Cartilage is the substance along joint arrangement, it can prevent bone Head end rubs mutually together, and allows joint to move freely in the state of full of joint fluid.When man-year year gradually old, human body Cartilage be worn, bone will expose, the joint of finger, knee, neck etc. be close together activity friction when will be special Other pain.In addition with the gradually aging of body, body itself generates the abilities of collagen and glucose amino glycans also not Disconnected decline, the recovery of articular cartilage tissue and connective tissue, reconstruction, regeneration function also decline therewith, it is easy to cause arthritis With the diseases such as painful swelling of joints, the hardship of pain is brought to patient, has seriously affected the health and life of people.

Although existing traditional drug has treatment or remission effect, but the position that conventional medicament is fallen ill just for painful swelling of joints The defects of effect, drug effect is slow and not lasting, easy to recur.

Summary of the invention

The present invention in order to solve the above technical problems, the present invention provides a kind of Chinese medicine composition for treating painful swelling of joints and its Preparation method.

Specifically realized according to following technical scheme：

The present invention provides a kind of Chinese medicine composition for treating painful swelling of joints, the Chinese medicine composition prescription is by following weight Number raw material composition：10-15 parts of the root of Chinese clematis, 10-15 parts of teasel root, 10-15 parts of rhizoma cibotii, 10-15 parts of radix paeoniae rubra, 10-15 parts of bletilla, Qiang 10-15 parts, 5-8 parts of aconiti preparata,radix, 10-15 parts of Cortex Eucommiae, 10-15 parts of leech, 10-15 parts of glutinous rehmannia, 5-8 parts of Semen Strychni (processed), Chinese ephedra living 5-10 parts, 10-15 parts of curcuma zedoary, 10-15 parts of Radix Angelicae Sinensis, 10-15 parts of safflower, 10-15 parts of rheum officinale, 10-15 parts of radix saposhnikoviae, 5-8 parts of Radix Glycyrrhizae, 10-15 parts of cortex cinnamomi, 10-15 parts of olibanum, 5-10 parts of myrrh, 10-15 parts of dragon's blood, 10-15 parts of Herba Epimedii, 10-15 parts of Rhizoma Chuanxiong, Paris polyphylla 10-15 parts, 10-15 parts of camphor.

Further preferably, the Chinese medicine composition prescription is made of following parts by weight raw material：12.6 parts of the root of Chinese clematis continues Disconnected 12.8 parts, 13.1 parts of rhizoma cibotii, 12.7 parts of radix paeoniae rubra, 12.1 parts of bletilla, 12.5 parts of Rhizoma Et Radix Notopterygii, 6.9 parts of aconiti preparata,radix, 12.3 parts of Cortex Eucommiae, 12.6 parts of leech, 12.4 parts of glutinous rehmannia, 6.4 parts of Semen Strychni (processed), 7.8 parts of Chinese ephedra, 13.2 parts of curcuma zedoary, 12.8 parts of Radix Angelicae Sinensis, safflower 12.3 Part, 11.9 parts of rheum officinale, windproof 12.4 parts, 7.0 parts of Radix Glycyrrhizae, 13.5 parts of cortex cinnamomi, 11.6 parts of olibanum, 8.2 parts of myrrh, dragon's blood 12.6 Part, 13.0 parts of Herba Epimedii, 13.4 parts of Rhizoma Chuanxiong, 12.0 parts of Paris polyphylla, 14.1 parts of camphor.

It is a further object to provide the preparation methods of the Chinese medicine composition for the treatment of painful swelling of joints, are by Chinese medicine group Close in object bulk pharmaceutical chemicals by pharmacological property temperature, it is cold, flat, hot, cool carry out through nanofiltration membrane, merging filtered fluid after classification extraction, then will surpass Membrane filtration, then through being concentrated under reduced pressure to get Chinese medicine composition.

The pharmacological property temperature, extracting method are：Pharmacological property temperature bulk pharmaceutical chemicals are lauched in temperature for 60-65 DEG C of condition and mention 2-3h, Water consumption is (7-9) times of pharmacological property temperature bulk pharmaceutical chemicals total weight.

The pharmacological property is cold, and extracting method is：Pharmacological property cold bulk pharmaceutical chemicals gross weight (5-7) times is added in the cold bulk pharmaceutical chemicals of chemotropism Water is then heated to 40-50 DEG C, keeps the temperature 30-45min, is then heated to 75-80 DEG C, keeps the temperature 1-1.5h, is then again heated to 90-95 DEG C, keep the temperature 30-40min.

The mild in medicine property, extracting method be, by mild in medicine property bulk pharmaceutical chemicals under the conditions of temperature is 50-58 DEG C alcohol extracting 1- 1.5h, (2-3) times of ethanol consumption mild in medicine property bulk pharmaceutical chemicals gross weight, ethyl alcohol mass concentration are 70-80%.

The pharmacological property heat, extracting method are：It is dense that pharmacological property hot charge medicine is placed in quality under the conditions of temperature is 10-15 DEG C Degree is after impregnating 1-2h in the acetum of 40-50%, and acetum dosage is (3-5) times of pharmacological property hot charge medicine gross weight, is set Constant temperature extracts 2-4h under the conditions of being 25-30 DEG C in temperature.

The pharmacological property is cool, and extracting method is：The cool bulk pharmaceutical chemicals gross weight (1.5-2) of pharmacological property times is added in the cool bulk pharmaceutical chemicals of chemotropism Mass concentration be 20-25% cmc soln low temperature impregnate 1-2h, pull out, be added the cool bulk pharmaceutical chemicals gross weight of pharmacological property The ethanol solution that the mass concentration of (2-2.5) again is 70-80% extracts 1-2h under the conditions of being 45-53 DEG C in temperature.

The low temperature impregnates, and temperature is 12-18 DEG C.

The nanofiltration membrane, molecular weight are 600-1000 dalton.

The ultrafiltration membrane, molecular weight are 2000-5000 dalton.

The reduced pressure is first to be concentrated into original volume 1/2 under conditions of pressure is 0.3-0.4MPa, then in pressure To be concentrated into original volume 1/3 under conditions of 0.2-0.28MPa, original then is concentrated under conditions of pressure is 0.09-0.15MPa Volume 1/4.

The Chinese medicine composition extract can be direct or pharmaceutically acceptable auxiliary material is added, and prepares various external preparations.

The dosage form of the external preparation includes but is not limited to emplastrum, spray, ointment.

The function, character of each raw material are as follows in Chinese medicine composition of the invention：

Root of Chinese clematis pharmacological property temperature, flavour of a drug are pungent, salty, return bladder meridian, nontoxic；With dispelling wind and eliminating dampness, the effect of removing obstruction in channels to relieve pain.For Rheumatic arthralgia, extremity numbness, muscle arteries and veins contraction, joint stuffiness, bone are choked with sobs larynx.

Teasel root pharmacological property temperature, flavour of a drug are pungent, bitter, return liver and kidney channel, nontoxic；With nourishing liver and kidney, continuous muscles and bones, the effect of adjusting blood vessels.It controls Aching pain in waist and back, the foot and knee being feeble, vaginal bleeding during pregnancy, metrorrhagia and metrostaxis, leukorrhagia, spermatorrhea, traumatic injury, metal-inflicted wound, anal fistula, ulcer sore swells.

Rhizoma cibotii pharmacological property temperature, flavour of a drug are sweet, bitter, return liver and kidney channel, nontoxic；With nourishing liver and kidney, the effect of strong spinal column, wind-damp dispelling.With In soreness and weakness of waist and knees, weakness of the lower extremities, rheumatic arthralgia.

RADIX PAEONIAE RUBRA is cold in nature, and flavour of a drug are bitter, return liver warp；With clearing heat and cooling blood, the effect of removing blood stasis and acesodyne.For febrile virulent maculae, spit Blood bleeding from five sense organs or subcutaneous tissue, red eye, swell pain, liver-depressed hypochondrium pain, amenorrhea and algomenorrhea, abdominal mass abdominal pain, injury from falling down, carbuncle swells sore.

Bletilla pharmacological property is cool, and flavour of a drug are sweet, bitter, distributed in lung channel, nontoxic；With astringing to arrest bleeding, the effect of detumescence and promoting granulation.For hemoptysis It spits blood, traumatic hemorrhage, sore swollen toxin, chapped skin；Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.

Rhizoma Et Radix Notopterygii pharmacological property temperature, flavour of a drug are pungent, bitter, return kidney, bladder meridian, nontoxic；With cold dispelling, the effect of wind-dispelling, dehumidifying, analgesic. It has a headache for anemofrigid cold, rheumatic arthralgia, aching pain in shoulder and back.

Aconiti preparata,radix pharmacological property heat, flavour of a drug are pungent, bitter, return heart, spleen, liver and kidney channel, toxic；With dispelling wind and eliminating dampness, the function of antalgic Effect.It is used for treating arthralgia due to cold and dampness, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain, narcotic analgesic.

Cortex Eucommiae pharmacological property temperature, flavour of a drug are sweet, return liver and kidney channel, nontoxic；With nourishing liver and kidney, the effect of strengthening the bones and muscles, miscarriage prevention.For kidney Virtual waist pain, muscles and bones is powerless, blood leaking in gestation, threatened abortion；Hypertension.

Leech mild in medicine property, flavour of a drug hardship, salty, return liver warp are toxic；With dissipating blood stasis with potent drugs, the effect of promoting menstruation eliminating mass.Main blood stasis warp It closes；Abdominal mass lump in the abdomen；Traumatic injury.

Glutinous rehmannia pharmacological property is cold, and flavour of a drug are sweet, bitter, return heart, liver and kidney channel；With clearing heat and cooling blood, yin-nourishing, the effect of promoting the production of body fluid.For heat The sick deep red polydipsia of tongue, yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, Heat Diabetes are spitted blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.

Semen Strychni (processed) pharmacological property temperature, flavour of a drug are bitter, and returns spleen, Liver Channel are toxic；With removing obstruction in channels to relieve pain, the effect of mass dissipating and swelling eliminating.For Rheumatoid arthritis stubborn, paralysis and numbness, injury from falling down, ulcer sore pain；Sequelae of infantile paralysis, rheumatoid arthritis.

Chinese ephedra pharmacological property temperature, flavour of a drug are pungent, bitter, return lung, bladder meridian；With sweating cold dispelling, freeing lung and relieving asthma, the function of inducing diuresis for removing edema Effect.It is uncomfortable in chest to breath with cough for anemofrigid cold, geomantic omen edema；Bronchial asthma.Herba ephedrae moistening lung to arrest cough.It is chiefly used in table disease to have solved, gas It breathes with cough and coughs.

Curcuma zedoary pharmacological property temperature, flavour of a drug are pungent, bitter, returns spleen, Liver Channel；With promoting the circulation of qi blood-breaking, the effect of clearing stagnation and killing pain.For Dan lump in the abdomen ruffian Block, blood stasis closed, dyspepsia distending pain；Early cervical carcinoma.

Radix Angelicae Sinensis pharmacological property temperature, flavour of a drug are pungent, sweet, return heart, spleen, Liver Channel；With benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing dryness and lubricating intestine Effect.Irregular menstruation is controlled, menostasis abdominal pain, abdominal mass knot is poly-, metrorrhagia and metrostaxis；Headache due to deficiency of blood, dizziness, flaccidity syndrome and arthralgia syndrome；Intestines are dry and shit is difficult, weight after dysentery with bloody stool；Carbuncle Subcutaneous ulcer sore is stolen, injury from falling down.

Safflower pharmacological property temperature, flavour of a drug are pungent, thoughts of returning home warp, nontoxic；With blood circulation, the effect of removing blood stasis and acesodyne.For menostasis, pain Through, lochia, abdominal mass lump in the abdomen, injury from falling down, sore swell and ache curative.

Elsholtzia is cold in nature, and flavour of a drug are bitter, return stomach, liver, large intestine channel, toxic；With rushing down real heat, break it is stagnant, the effect of row hemostasis. It cures mainly：Real heat constipation, dyspepsia are stagnated, abdominal pain, acute appendicitis, acute infectious hepatitis, blood stasis, toothache, and bleeding from five sense organs or subcutaneous tissue is acute Conjunctivitis；Burn and scald, suppurative dermatosis, carbuncle swells sore are controlled in external application.

Opopanax is warm-natured, and flavour of a drug are pungent, sweet, and returns spleen, liver, bladder meridian are nontoxic；With inducing diaphoresis to dispel wind, win wet, the function of relieving convulsion Effect.For cold headache, rheumatic arthralgia, rubella itch, tetanus.

Radix Glycyrrhizae mild in medicine property, flavour of a drug are sweet, return stomach, lung, the spleen channel, nontoxic；With clearing heat and detoxicating, moistening lung to arrest cough, coordinating the drug actions of a prescription Effect.Abscess of throat is cured mainly, is coughed, weakness of the spleen and the stomach, taste-blindness rate, hepatitis, hysteria, carbuncle and furuncle and pyogenic infections, drug and food Poisoning.

Cortex cinnamomi pharmacological property heat, flavour of a drug are pungent, sweet, return heart, spleen, liver and kidney channel, toxic；With supplementing Yuanyang, warming spleen and stomach, removing internal cold is led to The effect of blood vessels.The Yang-function insufficiency of kidneyzang, cold weak pulse of limb are controlled, yang depletion is collapsed, abdominal pain diarrhoea, cold hernia renal mass, waist and knee crymodynia, menostasis abdominal mass, Negative subcutaneous ulcer, streamer, and empty sun are floating more, heat in the upper and cold in the lower.

Olibanum pharmacological property temperature, flavour of a drug are pungent, bitter, return heart, spleen, Liver Channel, micro- poison；Has effects that promoting blood circulation and stopping pain.It is all for trusted subordinate Bitterly, muscle arteries and veins contraction, traumatic injury, sore, carbuncle and painful swelling；Externally used detumescence myogenic

Myrrh mild in medicine property, flavour of a drug are bitter, and return liver warp is nontoxic；With removing blood stasis and acesodyne, the effect of externally used detumescence myogenic.For falling Beat extravasated blood swelling and pain, ulcer sore pain, all pains of chest and abdomen；External application is controlled the open sore part and is not restrained long.

Dragon's blood mild in medicine property, flavour of a drug are sweet, salty, converge to heart and liver channels, mild toxicity；With removing blood stasis and relieving pain, the effect of hemostasia and promoting granulation.For Fall to flutter and lose, internal injury stasis caused pain；Traumatic hemorrhage is more than.

Herba Epimedii pharmacological property temperature, flavour of a drug are pungent, it is sweet, return liver and kidney channel, it is nontoxic；With kidney-replenishing, the effect of strengthening bones and muscles, dispelling wind and dampness. For impotence and seminal emission, muscles and bones impotence, rheumatic arthralgia, numbness contracture；Climacteric hypertension.

Rhizoma Chuanxiong pharmacological property temperature, flavour of a drug are pungent, return liver, gallbladder channel, nontoxic；With blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.For menstruation It is uncomfortable, amenorrhea and algomenorrhea, abdominal mass abdominal pain, pricking pain in the chest, tumbling and swelling, headache, rheumatic arthralgia.

Paris polyphylla pharmacological property is cold, and flavour of a drug are bitter, return liver warp, mild toxicity；Control swollen wound poisoning.

Camphor pharmacological property temperature, flavour of a drug are pungent, return heart, the spleen channel, toxic；With sensible, desinsection, dirty effect is warded off in analgesic.Control trusted subordinate Distending pain, tinea pedis, sore scabies, toothache, traumatic injury.

The beneficial effects of the present invention are：

The present invention has selected prestige by screening to a variety of Chinese medicines with activating microcirculation and removing stasis medicinal, inducing diuresis for removing edema, wind-expelling pain-stopping Medicine xiaolingxian, teasel root, rhizoma cibotii, radix paeoniae rubra, bletilla, Rhizoma Et Radix Notopterygii, aconiti preparata,radix, Cortex Eucommiae, leech, glutinous rehmannia, Semen Strychni (processed), Chinese ephedra, curcuma zedoary, Radix Angelicae Sinensis, Safflower, rheum officinale, radix saposhnikoviae, Radix Glycyrrhizae, cortex cinnamomi, olibanum, myrrh, dragon's blood, Herba Epimedii, Rhizoma Chuanxiong, Paris polyphylla, camphor are combined, and according to Pharmacological property carries out classification extraction, so that effective component is fully dissolved out in bulk pharmaceutical chemicals, and is interacted, has reached synergistic and attenuation Effect, and utilize Rational Classification pharmacological property, enable Chinese medicine composition effectively have the function that dredging collateral relax warp, in conjunction with The channel tropism of bulk pharmaceutical chemicals acts on, and Chinese medicine composition is enabled effectively to adjust the function of the heart, lung, spleen, liver, kidney, gallbladder, bladder, large intestine, In conjunction with the use of tung oil and red lead, the infiltration of effective component in Chinese medicine composition can be effectively facilitated, and then reaches and effectively controls Treat the purpose of painful swelling of joints.

Using preparation method provided by the invention, each bulk pharmaceutical chemicals active constituent can be being dissolved out to greatest extent, while can To promote effective component activity, to promote the absorption rate of effective component, achieve the purpose that quickly to treat painful swelling of joints, together When, improve the anti inflammatory detoxication ability of epidermal cell, there is dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, detumescence ding-tong effect is suitable for bruise and damages Wound, arthralgia and myalgia, rheumatic arthralgia, painful swelling of joints, osteoproliferation, the symptoms such as protrusion of the intervertebral disc.

The present invention treats the traditional Chinese medicine for outer use of painful swelling of joints, clinical to have carried out point to the patient of over thousands of example painful swelling of joints Class treats clinical application, reaches clinical symptoms and swollen joint distending pain completely disappears, function is normal, unrestricted healing of living 83.6% or more, total effective rate 99.7%, efficacy consolidation recurrence rate is 0.4%.

Specific embodiment

Specific embodiments of the present invention will be described in further detail below, but the invention is not limited to these realities Mode is applied, it is claimed to still fall within the claims in the present invention for any improvement or replacement on the present embodiment essence spirit Range.

Embodiment 1

A kind of Chinese medicine composition for treating painful swelling of joints, the Chinese medicine composition prescription is by following parts by weight raw material group At：Root of Chinese clematis 15g, teasel root 15g, rhizoma cibotii 15g, radix paeoniae rubra 15g, bletilla 15g, Rhizoma Et Radix Notopterygii 15g, aconiti preparata,radix 8g, Cortex Eucommiae 15g, leech 15g, glutinous rehmannia 15g, Semen Strychni (processed) 8g, Chinese ephedra 10g, curcuma zedoary 15g, Radix Angelicae Sinensis 15g, safflower 15g, rheum officinale 15g, radix saposhnikoviae 15g, Radix Glycyrrhizae 8g, cortex cinnamomi 15g, olibanum 15g, myrrh 10g, dragon's blood 15g, Herba Epimedii 15g, Rhizoma Chuanxiong 15g, Paris polyphylla 15g, camphor 15g.

Embodiment 2

A kind of Chinese medicine composition for treating painful swelling of joints, the Chinese medicine composition prescription is by following parts by weight raw material group At：Root of Chinese clematis 10g, teasel root 10g, rhizoma cibotii 10g, radix paeoniae rubra 10g, bletilla 10-g, Rhizoma Et Radix Notopterygii 10g, aconiti preparata,radix 5g, Cortex Eucommiae 10g, leech 10g, glutinous rehmannia 10g, Semen Strychni (processed) 5g, Chinese ephedra 5g, curcuma zedoary 10g, Radix Angelicae Sinensis 10g, safflower 10g, rheum officinale 10g, radix saposhnikoviae 10g, Radix Glycyrrhizae 5- 8g, cortex cinnamomi 10g, olibanum 10g, myrrh 5g, dragon's blood 10g, Herba Epimedii 10g, Rhizoma Chuanxiong 10g, Paris polyphylla 10g, camphor 10g.

Embodiment 3

A kind of Chinese medicine composition for treating painful swelling of joints, the Chinese medicine composition prescription is by following parts by weight raw material group At：Root of Chinese clematis 12.6g, teasel root 12.8g, rhizoma cibotii 13.1g, radix paeoniae rubra 12.7g, bletilla 12.1g, Rhizoma Et Radix Notopterygii 12.5g, aconiti preparata,radix 6.9g, Cortex Eucommiae 12.3g, leech 12.6g, glutinous rehmannia 12.4g, Semen Strychni (processed) 6.4g, Chinese ephedra 7.8g, curcuma zedoary 13.2g, Radix Angelicae Sinensis 12.8g, safflower It is 12.3g, rheum officinale 11.9g, radix saposhnikoviae 12.4g, Radix Glycyrrhizae 7.0g, cortex cinnamomi 13.5g, olibanum 11.6g, myrrh 8.2g, dragon's blood 12.6g, excessive Sheep leaves of pulse plants 13.0g, Rhizoma Chuanxiong 13.4g, Paris polyphylla 12.0g, camphor 14.1g.

Embodiment 4-6

Embodiment 4-6 on the basis of embodiment 1-3, prepares Chinese medicine composition respectively in accordance with the following steps：By Chinese medicine group Close in object bulk pharmaceutical chemicals by pharmacological property temperature, it is cold, flat, hot, cool carry out through nanofiltration membrane, merging filtered fluid after classification extraction, then will surpass Membrane filtration, then through being concentrated under reduced pressure to get Chinese medicine composition；

The pharmacological property temperature, extracting method are：Pharmacological property temperature bulk pharmaceutical chemicals are lauched in temperature for 63 DEG C of conditions and mention 2.5h, water is used Amount is 8 times of pharmacological property temperature bulk pharmaceutical chemicals total weight；

The pharmacological property is cold, and extracting method is：The water of cold 6 times of the bulk pharmaceutical chemicals gross weight of pharmacological property is added in the cold bulk pharmaceutical chemicals of chemotropism, so After be heated to 45 DEG C, keep the temperature 37min, be then heated to 78 DEG C, keep the temperature 1.3h, be then again heated to 92 DEG C, keep the temperature 35min；

The mild in medicine property, extracting method be, by mild in medicine property bulk pharmaceutical chemicals under the conditions of temperature is 55 DEG C alcohol extracting 1.2h, ethyl alcohol 3 times of dosage mild in medicine property bulk pharmaceutical chemicals gross weight, ethyl alcohol mass concentration are 70%；

The pharmacological property heat, extracting method are：Pharmacological property hot charge medicine is placed in mass concentration under the conditions of temperature is 15 DEG C After impregnating 1h in 50% acetum, acetum dosage is 3 times of pharmacological property hot charge medicine gross weight, and being placed in temperature is 30 DEG C Under the conditions of constant temperature extract 3h；

The pharmacological property is cool, and extracting method is：Cool 1.5 times of bulk pharmaceutical chemicals gross weight of the matter of pharmacological property is added in the cool bulk pharmaceutical chemicals of chemotropism It measures the cmc soln low temperature that concentration is 25% and impregnates 1.5h, pull out, cool 2 times of bulk pharmaceutical chemicals gross weight of the quality of pharmacological property is added The ethanol solution that concentration is 70% extracts 2h under the conditions of being 50 DEG C in temperature；

The low temperature impregnates, and temperature is 15 DEG C；

The nanofiltration membrane, molecular weight are 800 dalton；

The ultrafiltration membrane, molecular weight are 3000 dalton；

The reduced pressure is first to be concentrated into original volume 1/2 under conditions of pressure is 0.4MPa, is then in pressure It is concentrated into original volume 1/3 under conditions of 0.25MPa, is then concentrated into original volume 1/4 under conditions of pressure is 0.11MPa.

Embodiment 7-9

Tung oil, red lead is added in embodiment 7-9 on the basis of embodiment 4-6 respectively, is prepared into emplastrum, spray, soft The external preparations such as paste.

Test example 1

Raw material screening experiment

By to it is a variety of with activating microcirculation and removing stasis medicinal, inducing diuresis for removing edema, wind-expelling pain-stopping Chinese medicines screen, selected the root of Chinese clematis, Teasel root, rhizoma cibotii, radix paeoniae rubra, bletilla, Rhizoma Et Radix Notopterygii, aconiti preparata,radix, Cortex Eucommiae, leech, glutinous rehmannia, Semen Strychni (processed), Chinese ephedra, curcuma zedoary, Radix Angelicae Sinensis, safflower, Rheum officinale, radix saposhnikoviae, Radix Glycyrrhizae, cortex cinnamomi, olibanum, myrrh, dragon's blood, Herba Epimedii, Rhizoma Chuanxiong, Paris polyphylla, camphor, Radix Salviae Miltiorrhizae, the root of Dahurain angelica, cape jasmine, Radix Angelicae Pubescentis, The rhizome of davallia, Chinese pennisetum have good therapeutic effect to painful swelling of joints, therefore, such as the material combination of table 1：

Table 1

It uses hot-air seasoning to water content for 4-6% after bulk pharmaceutical chemicals are mixed, is milled to granularity through Ultramicro-powder and crosses 800 meshes, Then 5 times of raw material gross weight of water is added to be concentrated under the conditions of 0.35MPa after extracting 6h under conditions of temperature is 75 ± 2 DEG C Then original volume 1/2 is added tung oil, red lead, ointment is made；

The male patient of 60 painful swelling of joints is selected, the age in 40-45 years old range, is divided into 6 groups at random, then distinguishes It is carried out using, application method, 2 times a day, every time with the ointment of experimental group 1-5 preparation and control group using Ibuprofen cream 3g gently rubs 5min or so in sore place；Continuous use is discontinued after 1 month, and efficacy assessment standard is as follows：

It cures：Clinical symptoms disappear and do not recur for 3 months.

Effectively：Pain relief, dysarthrasis improve.

In vain：Symptom is not improved.

After being discontinued 3 months, statistics curative effect situation is as shown in table 2：

Table 2

Project	Cure number/example	Significant figure/example	Invalid number/example	Total effective rate/%
					Experimental group 1	7	3	0	100
Experimental group 2	1	4	5	50
					Experimental group 3	2	5	3	70
Experimental group 4	0	7	3	70
					Experimental group 5	2	7	1	90
Control group	0	8	2	80

Test example 2

Craft screening experiment

On the basis of embodiment 1, Chinese medicine composition is prepared using technique as described in Table 3, tung oil, red is then added Ointment is made in pellet：

Table 3

The male patient of 100 painful swelling of joints is selected, the age in 40-45 years old range, is divided into 5 groups at random, then divides Not Yong experimental group 1-5 preparation ointment, application method, 2 times a day, each 3g gently rubs 5min or so in sore place；Continuous use It is discontinued after 1 month, efficacy assessment standard is as follows：

It cures：Clinical symptoms disappear and do not recur for 3 months.

Effectively：Pain relief, dysarthrasis improve.

In vain：Symptom is not improved.

After being discontinued 3 months, statistics curative effect situation is as shown in table 4：

Table 4

Project	Cure number/example	Significant figure/example	Invalid number/example	Total effective rate/%
					Experimental group 1	16	4	0	100
Experimental group 2	11	8	1	95
					Experimental group 3	5	12	3	85
Experimental group 4	4	10	6	70
					Experimental group 5	6	11	3	80

Claims

1. a kind of Chinese medicine composition for treating painful swelling of joints disease, which is characterized in that the Chinese medicine composition prescription by weighing as follows Measure number raw material composition：10-15 parts of the root of Chinese clematis, 10-15 parts of teasel root, 10-15 parts of rhizoma cibotii, 10-15 parts of radix paeoniae rubra, 10-15 parts of bletilla, 10-15 parts of Rhizoma Et Radix Notopterygii, 5-8 parts of aconiti preparata,radix, 10-15 parts of Cortex Eucommiae, 10-15 parts of leech, 10-15 parts of glutinous rehmannia, 5-8 parts of Semen Strychni (processed), fiber crops 5-10 parts yellow, 10-15 parts of curcuma zedoary, 10-15 parts of Radix Angelicae Sinensis, 10-15 parts of safflower, 10-15 parts of rheum officinale, 10-15 parts of radix saposhnikoviae, Radix Glycyrrhizae 5-8 Part, 10-15 parts of cortex cinnamomi, 10-15 parts of olibanum, 5-10 parts of myrrh, 10-15 parts of dragon's blood, 10-15 parts of Herba Epimedii, 10-15 parts of Rhizoma Chuanxiong, 10-15 parts of Paris polyphylla, 10-15 parts of camphor.

2. the Chinese medicine composition for the treatment of painful swelling of joints as described in claim 1, which is characterized in that the Chinese medicine composition prescription It is made of following parts by weight raw material：12.6 parts of the root of Chinese clematis, 12.8 parts of teasel root, 13.1 parts of rhizoma cibotii, 12.7 parts of radix paeoniae rubra, bletilla 12.1 Part, 12.5 parts of Rhizoma Et Radix Notopterygii, 6.9 parts of aconiti preparata,radix, 12.3 parts of Cortex Eucommiae, 12.6 parts of leech, 12.4 parts of glutinous rehmannia, 6.4 parts of Semen Strychni (processed), Chinese ephedra 7.8 parts, 13.2 parts of curcuma zedoary, 12.8 parts of Radix Angelicae Sinensis, 12.3 parts of safflower, 11.9 parts of rheum officinale, windproof 12.4 parts, 7.0 parts of Radix Glycyrrhizae, cortex cinnamomi 13.5 parts, 11.6 parts of olibanum, 8.2 parts of myrrh, 12.6 parts of dragon's blood, 13.0 parts of Herba Epimedii, 13.4 parts of Rhizoma Chuanxiong, 12.0 parts of Paris polyphylla, camphor tree 14.1 parts of brain.

3. as claimed in claim 1 or 2 treatment painful swelling of joints Chinese medicine composition preparation method, which is characterized in that be by In Chinese medicine composition bulk pharmaceutical chemicals by pharmacological property temperature, it is cold, flat, hot, cool carry out merging filtered fluid through nanofiltration membrane after classification extraction, Again by ultrafiltration membrance filter, then through being concentrated under reduced pressure to get Chinese medicine composition.

4. the preparation method of the Chinese medicine composition for the treatment of painful swelling of joints as claimed in claim 3, which is characterized in that the nanofiltration Film, molecular weight are 600-1000 dalton.

5. the preparation method of the Chinese medicine composition for the treatment of wind painful swelling of joints as claimed in claim 3, which is characterized in that described super Filter membrane, molecular weight are 2000-5000 dalton.

6. the preparation method of the Chinese medicine composition for the treatment of painful swelling of joints as claimed in claim 3, which is characterized in that the decompression Concentration is first to be concentrated into original volume 1/2 under conditions of pressure is 0.3-0.4MPa, then in the item that pressure is 0.2-0.28MPa It is concentrated into original volume 1/3 under part, is then concentrated into original volume 1/4 under conditions of pressure is 0.09-0.15MPa.

7. the preparation method of the Chinese medicine composition for the treatment of painful swelling of joints as claimed in claim 3, which is characterized in that the Chinese medicine Composition extract can be direct or pharmaceutically acceptable auxiliary material is added, and prepares various external preparations.

8. the preparation method of the Chinese medicine composition for the treatment of painful swelling of joints as claimed in claim 7, which is characterized in that the external application The dosage form of preparation includes but is not limited to emplastrum, spray, ointment.