CN108785136A - The application of deodar essential oil - Google Patents
The application of deodar essential oil Download PDFInfo
- Publication number
- CN108785136A CN108785136A CN201710309056.9A CN201710309056A CN108785136A CN 108785136 A CN108785136 A CN 108785136A CN 201710309056 A CN201710309056 A CN 201710309056A CN 108785136 A CN108785136 A CN 108785136A
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- CN
- China
- Prior art keywords
- deodar
- essential oil
- skin
- application
- extenal use
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Links
- 241000218646 Cedrus deodara Species 0.000 title claims abstract description 86
- 239000000341 volatile oil Substances 0.000 title claims abstract description 63
- 150000001875 compounds Chemical class 0.000 claims abstract description 39
- 238000002360 preparation method Methods 0.000 claims abstract description 36
- 230000014509 gene expression Effects 0.000 claims abstract description 20
- 230000000694 effects Effects 0.000 claims abstract description 18
- 108010028309 kalinin Proteins 0.000 claims abstract description 18
- 239000000470 constituent Substances 0.000 claims abstract description 12
- 230000003712 anti-aging effect Effects 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 102000008186 Collagen Human genes 0.000 claims description 18
- 108010035532 Collagen Proteins 0.000 claims description 18
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- 239000002270 dispersing agent Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 10
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical & Material Sciences (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to cosmetic field, has and be used for skin preparations for extenal use, the especially skin preparations for extenal use with anti-senescence function as active constituent for deodar essential oil.Deodar essential oil and compound containing deodar essential oil can maintain corium bonding pad integrity and stability, significantly improve true epidermis bonding pad key protein Laminin 5 or COL VII expression, reach anti-aging effects, active constituent is can be used as, being used to prepare has effects that slow down aging, is anti-aging, in cosmetics that are keeping skin function.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to the compound of deodar essential oil and the essential oil containing deodar adds as effect
Add use of the agent in skin preparations for extenal use especially cosmetics.
Background technology
Deodar is Pinaceae deodar platymiscium, scientific name：Cedrus deodara (Roxb.) G.Don, alias Himalaya snow
Pine originates in Himalaya western part areas 1000~4000m of height above sea level.It is up to 75m, tree crown cone in source area.Originate in Asia
Continent is western, the Himalayas is western and Africa, Mediterranean, and deodar is aiphyllium, and tree crown steeple shape, bough is open and flat, small
Branch is slightly sagging；Leaf thorn shape, 8-60 centimetres long, matter is hard, celadon or silver gray, scattered on long shoot, fasciation on brachyplast；10-11
The moon blooms, and cone next year is ripe, and ellipticity is oval, russet when ripe.Deodar is one of world-renowned flower garden ornamental tree species, tool
There are stronger dust-proof, noise abatement and sterilizing ability, is also suitable for making industrial and mining enterprises' green tree species.
The history of the medication purposes of deodar is for a long time remote, can trace back to biblical times earliest.Containing abundant in cedar wood
Essential oil can be extracted from wood chip or sawdust it with the method for distillation.The main component of deodar essential oil include cedrol and
Wei De alcohol has the medical functions such as anti-corrosion, sterilization, diuresis, menstruation regulating, eliminating the phlegm, desinsection and calmness, additionally aid treatment of arthritis,
Bronchitis, rheumatism and respiratory problems are just applied to imperial palace beauty in ancient Egypt's period.
The convergence of deodar essential oil, antibacterial characteristics can be used for improving acne, pore obstruction and dermatitis, can also be used to treatment head
Scurf and fash improve Oily.
Skin covering is placed on entire human body surface, is in direct contact with external environment, in addition to protecting body from extraneous various
Outside the injury of factor, and it is the mirror for reacting general health status.Skin is made of epidermis, corium, subcutaneous tissue, and is contained
There are cutaneous appendages, abundant nerve, blood vessel, lymphatic vessel and muscle.It is also known as basilar memebrane in the join domain of corium and epidermis
Band is not only a model of a layered structure, and has various functions.Basilar memebrane is the supporting pad of epithelial cell, thin in epithelium
Born of the same parents organize to play structure connection function between connective tissue, meanwhile, also there is otherwise effect.For example, basilar memebrane conduct
The selectivity of cell usually can prevent phoirocyte from being contacted with the epithelial cell on basilar memebrane by barrier, but allow
Lymphocyte, macrophage and neuronal synapse pass through；In addition, the form of cell, the polarity of cell, cell metabolism, matter
Many biological phenomenas such as the distribution of protein, cell survival, the Proliferation, Differentiation of cell, cell migration, have with basilar memebrane on film
Very close relationship.
True epidermis bonding pad is mainly made of collagen, laminin, endonexin and diafiltration element.Collagen is a kind of
It is closely related, but the macromolecular that gene is different, it is had determined presently more than 20 kinds of vertebrate collagens.All collagen eggs
For white molecule by three polypeptide moieties, referred to as α chains, also human genome encodes these polypeptides in up to 25 different genes.
The different collagen of gene has characteristic Tissue distribution.For example, most abundant collagen such as I types and type III distribution are wide
General, less collagen is VII Collagen Type VI (COL VII), in corium and epidermal junction.The anchoring that collagen plays is made
With making to form firm connection between true epidermal cell, lack corresponding collagen or related gene mutates, can cause
A variety of diseases, such as bullous diseases etc..
Laminin (Laminin) is a kind of non-collagen glycoprotein with a variety of biological functions, in the structure of basilar memebrane
Build and the sticking, grow, migrating of Epidermal basal layer cells, break up in play vital role.Laminin is by α, β
" ten " word or " T " font structure are assembled by disulfide bond with tri- polypeptide chains of γ, have a long-armed (polypeptide chain in molecule
C-terminus pass through disulfide bond polymerization and constitute) and three galianconism (aminoterminal of three polypeptide chains is formed).Have and IV in molecule
The functional site that Collagen Type VI, cell and proteoglycan combine.At present, it has already been proven that laminin composition polypeptide chain have 5
α chains, 3 β chains and 3 γ chains find 15 kinds of laminins, wherein Kallinin is in basilar memebrane net so far
Shape structure builds and mediates basal layer cell sticking on basilar memebrane, migrate, than other kinds of laminin work
Use bigger.Kallinin (Laminin 5) synthesizes in the intracytoplasmic rough surfaced endoplasmic reticulum (RER) of epithelial cell, is initially formed 3 γ 2 of β
Dimer re-forms 3 β of α, 3 γ, 2 tripolymers, and extracellular substrate is secreted into after completing glycosylation in Golgi complex
In film, play an important role during the sticking, go back to the nest etc. of basal layer cell in the structure of basilar memebrane, reparation and adjusting.
True epidermis bonding pad separates epidermal basal cell with the tissue being connected positioned at its lower layer, and knot is provided to cell
Structure supports, and is adjusted by cell factor between epidermal-dermal, maintains function between epidermal-dermal.With age and ultraviolet light
Irradiation can cause the overlapping and fracture of skin basement membrane.Its connection between epidermis, corium, information transmission are hindered, can
It is worried to cause a variety of skin, or even cutaneous lesions.Therefore the smooth cycle between epidermis-basilar memebrane-corium three is linked up, and is structure
It an important factor at healthy skin, can be referred to as " gold cycle ".Cause the factor that basilar memebrane changes varied, light
Aging is one of key factor.The light aging mediated by UV is mainly by causing the change of main component level in basilar memebrane
Change, lead to the change of basilar memebrane function, to influence epidermis and corium function, causes having some setbacks for " gold cycle " between three
Freely, cause various skin problems.
Therefore, how research maintains the stability of true epidermis bonding pad, for protecting health, the delay skin aging of skin
It is of great significance.
There is no deodar essential oils or its compound at present for improvement or delay skin aging, maintains true epidermis bonding pad
The report of stability and firm basal membrane structure also improves laminin table without deodar essential oil or its compound
Reach or promote the report of collagen synthesis.
Invention content
The present invention is directed to deodar essential oil is used for skin preparations for extenal use, the especially skin preparations for extenal use with anti-senescence function.
The present invention also provides a kind of compounds of essential oil containing deodar, i.e. deodar essence compound, and by this compound
For skin preparations for extenal use, especially there is the skin preparations for extenal use of anti-senescence function.
Deodar essential oil can be used as active constituent, be used to prepare skin preparations for extenal use, be used especially as the active constituent of anti-aging
In skin preparations for extenal use.
Deodar essential oil has the function of maintenance corium bonding pad integrity and stability, can also promote generation layer adhesion egg
White or collagen can be used as active constituent for skin preparations for extenal use.
The expression that deodar essential oil increases skin layer thickness, improves Laminin 5 or COL VII.
Have using deodar essential oil as the skin preparations for extenal use of active constituent and maintains corium bonding pad integrity and stability
Effect can also promote to generate laminin or collagen.Such skin preparations for extenal use can increase skin layer thickness, improve
The expression of Laminin 5 or COL VII.
The additive amount of deodar essential oil be 0.00001wt%~10wt%, preferably 0.00005wt%~5wt%, more preferably
For 0.0001wt%~3wt%.
A preferred embodiment of the present invention is shown, when deodar essential oil content is 0.0001wt%, it will be able to dramatically increase
Skin layer thickness, the expression for improving Laminin 5 and COL VII, to improve skin function, delay skin aging.
Skin preparations for extenal use is cosmetics, such as toner, Essence, lotion, creams, facial mask, eye cream, smoothing toner, skin toner
Water, washing cream, suncream/breast, foundation emulsion, lipstick etc..Skin preparations for extenal use contains acceptable carrier.
Containing other with moisturizing, anti-aging, antiallergy, sun-proof or whitening function activity in the skin preparations for extenal use
Ingredient.
Preferably, contain glacial water in skin preparations for extenal use.Glacial water pH value be 7.1~7.9, deuterium content be 130~
140ppm also contains following component：Sr2+0.2~0.5mg/L, K+0.5~10.0mg/L, Na+1.0~5.0mg/L, Ca2+14.0
~30.0mg/L and Mg2+2.0~10.0mg/L；And the total dissolved solid content in glacial water is 60~150mg/L, no
Containing bromate.Preferably, the pH value of glacial water is 7.2~7.6, more preferably 7.4.Preferably, glacial water is Himalaya ice
Chuan Shui.
Preferably, also contain dispersant in skin preparations for extenal use.Those skilled in the art can select dispersant as needed
Type and content, such as caprylic/capric triglyceride etc..
Deodar essential oil is using cedar wood and/or bark as raw material, and especially Himalaya cedar wood and/or bark are raw material,
It is prepared by steam distillation, cold-maceration or carbon dioxide supercritical extraction method.
Preferred extracting method is steam distillation or carbon dioxide supercritical extraction method.Steam distillation step packet
It includes：
(1) cedar wood and/or bark is submerged in water, 95~110 DEG C are distilled and collect fraction；
(2) fraction takes oil phase and dry filter through water-oil separation, and deodar essential oil is made.
In step (2), to accelerate water-oil separation, salt can be added in fraction and carry out water-oil separation, such as sodium chloride, sulphur
The solid and/or solution of sour sodium or sodium bicarbonate；Oil phase anhydrous sodium sulfate or anhydrous magnesium sulfate is taken to dry, and micro porous filtration.
The compound of the essential oil containing deodar, i.e. deodar essence compound, component include deodar essential oil and glacial water, moderate snow
The weight ratio of loose essential oil and glacial water is 1：10~40000, preferably 1：100~30000, more preferably 1：5000~25000.
Glacial water pH value is 7.1~7.9, and deuterium content is 130~140ppm, is free of bromate, also contains following component：
Sr2+0.2~0.5mg/L, K+0.5~10.0mg/L, Na+1.0~5.0mg/L, Ca2+14.0~30.0mg/L and Mg2+2.0~
10.0mg/L；And the total dissolved solid content in glacial water is 60~150mg/L.Preferably, the pH value of glacial water is 7.2
~7.6, more preferably 7.4.Preferably, glacial water is Himalaya glacial water.
The compound of the essential oil containing deodar also contains dispersant, is used for homogeneous and stabilization.Those skilled in the art can be according to normal
Know the type of selection dispersant and the amount ratio of deodar essential oil and dispersant.
Caprylic/capric triglyceride can be selected in dispersant.
Preferably, deodar essential oil and dispersant dosage ratio are 1：1~500；More preferably 1：10~200.
In the preferred embodiment of the present invention, the group of the compound of the essential oil containing deodar becomes：Himalaya deodar essential oil and
Dispersant caprylic/capric triglyceride total amount 0.5wt%, glacial water 99.5wt%.Wherein, deodar essential oil and dispersant octanoic acid/
Triglyceride DDD weight ratio 1：99.
The compound of the essential oil containing deodar is prepared by the following method：After deodar essential oil and dispersant mixing, glacier is added
Water is uniformly mixed.The compound obtained can be added in skin preparations for extenal use.
The compound of the essential oil containing deodar can be used for preparing skin preparations for extenal use as active constituent, especially have anti-aging
The skin preparations for extenal use of function.
The compound of the essential oil containing deodar is active constituent, can be used for preparing having and maintains corium bonding pad stability and complete
Property effect skin preparations for extenal use.
It can promote to generate laminin alternatively, the compound of the essential oil containing deodar as active constituent, can be used for preparing
Or the skin preparations for extenal use of collagen.
Alternatively, the compound of the essential oil containing deodar can be used as active constituent, it is used to prepare and increases epidermal thickness, improves
Laminin 5 or the skin preparations for extenal use of COL VII expression.
The compound of the essential oil containing deodar can also add other moisturizings, anti-aging, antiallergy, sun-proof or whitening function work
Property ingredient.
In skin preparations for extenal use, the additive amount of the deodar essence compound as active constituent is 0.01wt%~90wt%,
Preferably 0.5wt%~60wt%；In terms of the weight of deodar essential oil, content can generate notable effect when being 0.0001wt%
Fruit.
Skin preparations for extenal use is cosmetics, including toner, Essence, lotion, creams, facial mask, eye cream, smoothing toner, skin toner
Water, washing cream, suncream, foundation emulsion, lipstick etc..
Present invention firstly provides the thickness that, deodar essential oil or deodar essence compound can obviously increase epidermis, and significantly
The expression of 5 albumen of key protein COL VII albumen and Laminin of the true epidermal junction of skin is improved, has and maintains DEJ (true
Epidermal junction) structural integrity, protect long-term stability function, can be used for prepare have effects that anti-aging, it is anti-aging,
Epidermis new life is peomoted, the skin preparations for extenal use that true epidermal structure keeps skin function, especially cosmetics are tightened.
Description of the drawings
Fig. 1 is untreated fish group and sample sets 3D skin model epidermal thickness image analyses in embodiment 3
Fig. 2 is 5 immunofluorescence expression analysis of untreated fish group and sample sets Laminin in embodiment 4
Fig. 3 is untreated fish group and sample sets COL VII immunofluorescence expression analysis in embodiment 4
Specific implementation mode
The extraction of 1 Himalaya deodar essential oil of embodiment
Use water distillation method extract Himalaya deodar essential oil the step of for：
1. the Himalaya deodar wood raw material of acquisition to be cut into the segment of 1.5~5cm, moisture content is drained after being rinsed with clear water,
And the humidity of timber is kept, it is put into steamer, distilled water is added to the height for not crossing timber；
It is heated 2. steamer is placed in distilling apparatus；It is distilled 2~3 hours at 100~105 DEG C, collects fraction and obtain grease
Mixture；It can directly be passed through 100~105 DEG C of steam heatings into steamer or heated with electric heating cover；
3. oil-water separation mixture：Oil phase is taken after oil water mixture layering；
To accelerate water-oil separating, consolidating for sodium chloride, sodium sulphate, sodium carbonate or sodium bicarbonate can be added into oil water mixture
Body or saturated solution, until salinity is 0.1~0.2g/mL in oil water mixture；
4. dry filter：Anhydrous magnesium sulfate or anhydrous sodium sulfate are added in oil phase and removes moisture removal, then with 0.22 μm of microporous barrier
Filtering, obtains Himalaya deodar essential oil.
It can also use and use CO 2 supercritical method, Himalaya deodar essence is extracted from Himalaya cedar wood
Oil.
Laminin (Laminin) is the major protein of true epidermis bonding pad, structures of the wherein Laminin5 in basilar memebrane
Build and the sticking, grow, migrating of Epidermal basal layer cells, break up in play an important role, and than other kinds of laminin
Act on bigger.VII Collagen Type VIs are the collagens that content is less in true epidermis, are made in the anchoring that corium and epidermal junction play
With making to form firm connection between true epidermal cell.
True epidermal junction be react skin barrier effect important representative, therefore in order to verify Cedarwood extract to protect
The effect of protecting true epidermal junction, our upgrowth situations and Laminin 5 and COL from the 3D skin models after sample treatment
Two aspects of fluorescent staining intensity of two antibody of VII are analyzed.
If after adding deodar essential oil, the growth conditions of skin model are good, and the integrality of true epidermis bonding pad is better than
Sample sets are not added with, and then can detect luciferase expression amount by way of Laminin 5 and COL VII immunofluorescence dyeings,
If relative to its expression quantity rising of the control group of deodar essential oil is not added with, you can reflection deodar essential oil is to protecting true epidermis to connect
The integrality in area has effect, further reaches anti-aging function.
The preparation of 2 deodar essence compound of embodiment
The deodar essential oil of 1g is uniformly mixed with 99g caprylic/capric triglycerides；Take 0.5g said mixtures and 99.5g
Glacial water mixing, as Himalaya deodar essence compound, initial concentration 1.In cytologic experiment, follow-up effect
Assessment detection uses 2% Himalaya deodar essence compound.
Glacial water is derived from the more lucky songs of Himalaya north slope and steps on Nima spring, is free of bromate, pH=7.4, deuterium content 133-
134ppm contains following component：Sr2+0.2~0.5mg/L, K+0.5~10.0mg/L, Na+1.0~5.0mg/L, Ca2+14.0~
30.0mg/L and Mg2+2.0~10.0mg/L；And the total dissolved solid content in glacial water is 60~150mg/L.
Embodiment 3Masson dyeing observation epidermal thicknesses
Test method is as follows：
(1) culture of 3D skin models
In human fibroblasts NHDF-P4 generations and human keratinized cell NHEK-P2 generations, are inoculated into dermal scaffold, passed through successively
Corium cultivation stage, epidermis submergence culture and liquid phase cultivation stage, carry out the structure of 3D skin models；In incubation, from
On holder be inoculated with fibroblast after D3 to final D35, respectively with ordinary culture medium or contain 2% Himalaya deodar
The culture medium of succinct compound cultivates skin model.
Himalaya deodar essence compound is made according to the method for embodiment 1, mainly by deodar essential oil and Himalaya
Glacial water forms, and initial concentration is as 100%.
It will be defined as untreated fish group (NT) with the 3D skin models of ordinary culture medium culture, with containing 2% Himalaya deodar
The skin model of succinct compound medium culture is defined as sample sets.
(2) epidermal thickness is analyzed
Skin model is cut into slice by paraffin section technology.It is dyed with hematoxylin working solution, then is immersed in distilled water
Then middle cleaning uses basic fuchsin dye liquor to dye；It is cleaned with Salkowski's solution, then is dyed with brilliant green dye liquor, deionized water is used in combination
Cleaning.Finally carry out dehydration mounting.
Epidermal thickness analysis method be：Sample sets and each 3 Masson dyeing picture of untreated fish group are taken, every takes 10
Point record epidermal thickness value and 3 groups of observed values, are analyzed, analysis result such as Fig. 1 after being averaged.
In the experiment that 3D skin model epidermal thicknesses measure, if being added to the skin model upgrowth situation of extract more
Good, epidermal thickness then can tentatively judge that deodar essence compound has certain good work(to skin growth higher than group is not added with
Effect, can improve skin function.
The Masson of untreated fish group and sample sets dyes picture the results show that two groups of 3D skin models have complete true table
Skin junction, and skin portion differentiation normally has basal layer, spinous layer, stratum granulosum and cuticular layer, illustrates to build 3D skin models
Succeed and can be used for analyzing with skin similar functions；And as shown in Figure 1,2% Himalaya deodar essence compound is added
The thickness of sample sets 3D skin models improves 20% than untreated fish group, and epidermal thickness dramatically increases, and illustrates that 2% happiness horse traction is added
Refined deodar essence compound can improve skin function, have the function of helping delay skin aging.
The luciferase expression of embodiment 4 Laminin 5 and COL VII
The cultural method of 3D skin models is the same as embodiment 2.
After culture 32 days, the freezing microtome section of the 3D skin models of untreated fish group and sample sets is fixed with cold acetone；PBS is multiple
After water, the PBS solution containing serum is added, is stored at room temperature 1h.5 antibody of primary antibody Laminin and COL VII antibody is added in 4 DEG C of mistakes
Night, next day are added corresponding secondary antibody Alexa Fluro 568anti-mouse and DAPI room temperatures and are protected from light incubation.Dyeing finally adds
Enter mountant mounting, fluorescence microscopy microscopic observation is taken pictures.
In the experiment of immunofluorescence dyeing, if relative to the groups of cells for being not added with extract, 5 Hes of Laminin
The luciferase expression amount of COLVII is significantly raised, and true epidermal junction is more complete, and deducibility deodar essence compound can induce
The expression of the Laminin 5 and COL VII of true epidermis bonding pad are conducive to the firm of DEJ basement membrane structures, finally play and help
In the effect of delay skin aging.
As a result such as Fig. 2 and Fig. 3.It can be seen that, compared with untreated fish group, 2% Himalaya is added from immunofluorescence analysis
5 protein expressions of sample sets Laminin of deodar essence compound increase 20%, COL VII expression and improve 47%.Layer is viscous
Even as the key protein in DEJ, help maintains DEJ structures, stablizes true epidermis for albumen Laminin 5 and VII collagen types
Connection and aging be closely related.Fig. 2,3 result explanation, Himalaya deodar essence compound can significantly improve very
The expression of Laminin 5 and COL VII, have activated key protein in epidermis bonding pad, contribute to delaying skin to decline to play
Old effect.
Using the Himalaya deodar essential oil of supercritical carbon dioxide extracting, epidermal thickness can be equally obviously increased, is shown
Write the expression for improving Laminin 5 and COL VII in true epidermis bonding pad.
Conclusion
Culture 3D skin models are built by embodiment 2 and 3 to find, compared to untreated fish group, contain Himalaya deodar
The culture medium of essential oil and Himalaya deodar essence compound can enhance skin function, and epidermal thickness is made to increase by 20%；And it can
To significantly improve the key protein expression of the true epidermal junction of skin, COL VII protein expressions can be made to increase by 47%, Laminin
5 protein expressions increase by 20%.Illustrate that Himalaya deodar essential oil can be by activating the true epidermis of raising to connect with succinct compound
The expression of area key protein Laminin 5 and COL VII, to promote true epidermal junction to play the work of raising skin function
With the effect of being conducive to the firm of basement membrane structure, improve skin function, contributing to delay skin aging to finally play
Effect.
Claims (12)
1. application of the deodar essential oil in terms of preparing skin preparations for extenal use.
2. application of the deodar essential oil in terms of preparing the skin preparations for extenal use with anti-senescence function.
3. deodar essential oil is preparing with the bonding pad integrity and stability effect of maintenance corium, is increasing skin layer thickness, promotion
Generate the application in terms of the skin preparations for extenal use of laminin or collagen.
4. deodar essential oil is in terms of preparing the skin preparations for extenal use for increasing skin layer thickness, raising Laminin 5 or COL VII expression
Application.
5. Claims 1 to 4 any one of them application, which is characterized in that the deodar essential oil is with cedar wood and/or bark
For raw material, preparation method includes steam distillation, cold-maceration or carbon dioxide supercritical extraction method.
6. Claims 1 to 4 any one of them application, which is characterized in that the skin preparations for extenal use contains moisturizing, anti-ageing
Always, antiallergy, sun-proof or whitening function active constituent.
7. Claims 1 to 4 any one of them application, which is characterized in that the skin preparations for extenal use contains glacial water.
8. the compound of the essential oil containing deodar, which is characterized in that component includes deodar essential oil and glacial water.
9. the compound of the essential oil containing deodar described in claim 8, which is characterized in that the weight ratio of the deodar essential oil and glacial water
It is 1：10~40000.
10. the compound of claim 8 or 9 essential oils containing deodar, which is characterized in that also contain dispersant.
11. the compound of the essential oil containing deodar described in any one of claim 8~10 is being prepared outside the skin with anti-senescence function
With the application in terms of agent.
Maintain corium bonding pad complete 12. the compound of the essential oil containing deodar described in any one of claim 8~10 has in preparation
Property and stability action, can promote to generate laminin or collagen, increase skin layer thickness or raising
Application in terms of the skin preparations for extenal use that Laminin 5 or COL VII are expressed.
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