CN108783465A - A kind of nutrition formula product with oncotherapy function - Google Patents

A kind of nutrition formula product with oncotherapy function Download PDF

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Publication number
CN108783465A
CN108783465A CN201810493894.0A CN201810493894A CN108783465A CN 108783465 A CN108783465 A CN 108783465A CN 201810493894 A CN201810493894 A CN 201810493894A CN 108783465 A CN108783465 A CN 108783465A
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parts
collagen
sea cucumber
formulation product
polysaccharide
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赵成军
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Hubei And Composite Bone Collagen Biological Technology Co Ltd
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Hubei And Composite Bone Collagen Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention provides a kind of nutrition formula products with oncotherapy function, are mainly made of the raw material of following parts by weight：1-50 parts of collagen；1-30 parts of sea cucumber peptide；1-30 parts of pachymaran；1-40 parts of fucoidin；With 1-40 parts of Radix Notoginseng.The present invention passes through each raw material component scientific compatibility, it can realize and control effect to tumour is reached to the reparation of human autoimmune's system, compared with traditional medicinal treatment and chemicotherapy, there is good effect in terms of anti-curing oncoma, the advantages that safe and non-toxic, can achieve the purpose that anti-curing oncoma.

Description

A kind of nutrition formula product with oncotherapy function
Technical field
The present invention relates to a kind of compound composition, more particularly to a kind of nutrition formula product with oncotherapy effect, More particularly to a kind of formulation product prepared as raw material using collagen, sea cucumber peptide, pachymaran, fucoidin and Radix Notoginseng.
Background technology
The risk factor of cancer cell (tumour) is divided into：The inherent induced environment factor of extraneous risk factor and human body.
Extraneous risk factor includes：Physical factor, chemical factor and biological factor.Wherein physical factor have external force damage, Chronic mechanical stimulus, ultraviolet light, radioactive substance stimulation, high temperature and pressure stimulation, environment temperature drastic change etc..Chemical factor includes Tobacco and wine stimulation in daily life, oil smoke stimulation, finishing material stimulation and non-live common benzene, ethylene oxide, coal tar The stimulation of 63 kinds of chemical substances such as pitch, asbestos, chloromethyl ether.Biological factor is mainly virus, bacterium, parasite.Experiments have shown that There are more than 30 more than 150 strain virus of kind that can cause animal tumor, some of viruses that can cause human tumor.Above-mentioned three big factor It influences, adverse changes will be generated to the internal environment, tissue and cell of human body, to induce the growth of cancer cell (tumour).
The inherent risk factor of human body：Due to influence and variation that extraneous factor generates human body internal environment factor, lead Normal cell is caused no longer to divide and be proliferated, to provide environmental factor and condition for the growth of cancer cell (tumour).
Due to the destruction of various risk factors, human normal cell is made to make a variation, tumour cell phagocytosis mutant obtains It must grow, growth of tumour cell while secretes a large amount of hyaluronidases to decompose, destroy the defence of the barrier in human body system System --- " molecular sieve ".
Currently, clinically common oncotherapy means mainly have surgical operation, internal medicine chemotherapy and radiotherapy etc..But It is radiation and chemotherapy while killing patient's body tumour cell, also destroys organism normal cell and immunocyte, cause more Kind tissue and organ damage, especially many chemical synthesis anticarcinogens can cause the serious secondary work such as lesions of liver and kidney and cardiac toxic With.Body can also lead to immunologic hypofunction because of the damage of immune system, prevent immune surveillance system from normally playing a role And induce other tumours.In addition, patient will produce drug resistance to chemotherapeutics in use, not only same type drug is generated Drug resistance, and the entirely different chemotherapeutics of chemical constitution therewith and the mechanism of action also will produce and intersect anti-medicine, greatly drop Low drug effect and therapeutic effect, cause therapeutic effect undesirable.
Therefore, it finds a kind of high efficiency, low side effects of and immune system can be repaired, improve the cancer therapeutics of immunity of organisms Object has become the new focus of international focus of attention.Natural products has compared with other antitumor drugs especially chemotherapeutics The advantages that low toxicity is efficient, multipath multiple target point adjusts immunity of organisms, quality-high and inexpensive, application clinically and development potentiality It will be boundless.
The present invention can realize the reparation to human autoimmune's system and prevention and treatment to tumour, with traditional medicine Object therapy and chemotherapy are compared, and have many advantages, such as low side effect, good effect and safe and non-toxic, can reach the mesh of nutrition treatment 's.
Invention content
By studying for a long period of time discoverys, the present invention is used for the alimentation composition of oncotherapy and passes through the glue that is included the present inventor The negative electricity characteristic of former albumen can promote the synthesis and utilization of positive electricity nutriment in body；In vivo by typeⅡ Collagen " molecular sieve " immunization barrier formed can resist the invasion of alien bacteria and virus, be more than the particulate material such as cancer of its micropore Then there is barrier action, the growth and breeding of the fast quick-recovery normal cell of typeⅡ Collagen to prevent in vivo just for cell, bacterium etc. Normal cell further makes a variation, and allows tumour cell gradually to lose growing environment, and in sea cucumber peptide, pachymaran, fucoidin, Radix Notoginseng Under the action of equal nutriments, inhibit the growth of tumour cell, providing more excellent, safe, natural having for consumer swells The formula food of tumor nutrition treatment.
Therefore, the present invention provides the following terms：
1. a kind of nutrition formula product with function of tumor, wherein the formulation product includes following by weight Item is made of the following terms：1-50 parts of collagen；1-30 parts of sea cucumber peptide；1-30 parts of pachymaran；1-40 parts of fucoidin With 1-40 parts of Radix Notoginseng.It is preferred that above-mentioned parts by weight are dry weight parts by weight.Term " dry weight " means that water content is less than 5% herein (wt), preferably shorter than 4%, 3%, 2%, 1%, 0.5%, 0.2% or 0.1%.
2. according to the formulation product described in above 1, wherein the formulation product include by weight the following terms or by The following terms forms：30-50 parts of collagen；15-30 parts of sea cucumber peptide；15-30 parts of pachymaran；15-30 parts of fucoidin；With 25-40 parts of Radix Notoginseng.
3. according to the formulation product described in above 1 or 2, wherein the collagen is I-type collagen, II Collagen Type VI eggs (compound ossein), type III collagen or their mixture in vain, and/or (such as chicken cartilage, fish is soft from biological cartilage Bone, ox cartilage, pig cartilage and other biological cartilages), fish scale, animal skin (such as fish-skin, pigskin, ox-hide and other biological skins Skin), biological tendon tissue, bone extraction collagen, ossein, bone collagen, bone collagen peptide, collagen obtained Peptide, I-type collagen, II collagen types (compound ossein), type III collagen, gartilage powder or combination thereof.
4. formulation product according to any one of claim 1 to 3, wherein the Radix Notoginseng is selected from and to be made up of Group：Sanchi flower, Roots of Panax Notoginseng, Radix Notoginseng palpus, Radix Notoginseng stem, sanchi leaf and its polysaccharide, saponin(e, extract or combination thereof, preferably Roots of Panax Notoginseng or stem.
5. formulation product according to any one of claim 1 to 4, wherein the pachymaran derives from Poria cocos Powder, tuckahoe extracts or su-fuling.
6. formulation product according to any one of claim 1 to 5 is made up of wherein the sea cucumber peptide is selected from Group：Sea cucumber powder, sea cucumber extract, sea cucumber polysaccharide, sea cucumber peptide or combination thereof, preferably sea cucumber peptide.
7. formulation product according to any one of claim 1 to 6, wherein the polysaccharide from Dunaliella salina is selected from by with the following group At group：Rock algae powder, rock algae extract or combination thereof, preferably fucoidin.
8. formulation product according to any one of claim 1 to 7, wherein the formulation product is by weight also May include 1-50 parts ginseng, bird's nest, tremella polysaccharides, Auricularia polysaccharide, mushroom polysaccharide, Chinese yam polysaccharide, chitosan oligosaccharide, taurine, Huang Stilbene, pollen pini, ganoderma lucidum, ganoderma lucidum polysaccharide, colostrum, spirulina, propolis, matrimony vine, algal polysaccharides, swan-mussel polysaccharide or their group It closes, also includes food additives and/or the pharmaceutic adjuvants such as one or more sweeteners, flavoring agent, stabilizer, colorant.
9. the formulation product according to any one of above 1 to 8 can be configured to powder, particle, solution, suspension Liquid, tablet or capsule pharmaceutical dosage form or be formulated into beverage, dairy products, milk powder, bread, soft or boiled goods, special doctor Learn purposes formula food, biscuit, noodles or the food form for meal product.
10. a kind of method preparing the formulation product according to any one of above 1 to 9, the method includes：By institute It states collagen, sea cucumber peptide, pachymaran, fucoidin and panax mixed and the formulation is made (for example, food, health care Food, nutriment and drug).
Specific implementation mode
According to an aspect of the invention, there is provided a kind of formulation product with tumors of nutrients therapeutic effect, wherein institute It states containing collagen, sea cucumber peptide, pachymaran, fucoidin and Radix Notoginseng.
Collagen [the II collagen types (compound ossein) for preferably comprising negative electricity molecule mucopolysaccharide]
In the present invention, the collagen can be I-type collagen, II collagen types (compound ossein), III Collagen type or their mixture, and/or from biological cartilage (such as chicken cartilage, fish cartilage, ox cartilage, pig cartilage and Other biology cartilages), fish scale, animal skin (such as fish-skin, pigskin, ox-hide and other biological skins), biological tendon tissue, bone Extraction collagen, ossein, bone collagen, bone collagen peptide, collagen peptide, I-type collagen, II Collagen Type VIs obtained Albumen (compound ossein), type III collagen, gartilage powder or combination thereof.
II collagen types (compound ossein) unique nutritional ingredient is (rich in hyaluronic acid, chondroitin sulfate, sulfuric acid angle Quality) and biological nature, the not connection breaking formation hyaluronic acid column for the hyaluronan molecule chain for keeping us internal, hyaluronic acid knowledge Not, affine, connection amino acid forms core protein column, and chondroitin sulfate, keratan sulfate different form are connected to core protein On column, the electronegative proteoglycan aggregate of macromolecular long-chain of grid structure is eventually formed, intensive proteoglycan is poly- in vivo Fit three-dimensional more micropores " molecular sieve " the formation human immunity barriers of structure in vivo, the infringement of tissue bacterial, virus, antitumor, Antiviral, anti-oxidant, anti-aging, adjustment endocrine.
Pachymaran
Pachymaran (Pachymaran) derives from On Polyporaceae Poria cocos (Poria cocos Wolf).In Poria cocos core B- pachyman (b-Pachyman) account for about 93%, the b- pachyman of Poria cocos core dry weight and transform into b- pachymarans (b- Pachymaran), just active.Containing there are many macroelements and trace element such as Ca, Mg, Cu, Fe, Zn, P in pachymaran And Se, S, Mn, Cr, Co, Cu, V etc., Harmful Trace Elements such as As, Pb, Cd etc. are free of, these trace elements also have certain Pharmacological action.
Pachymaran can not only improve non-specific immune systems function, and can improve specific immune system work( Energy.Humoral immune reaction and mouse immune response early immune competent cell of the mouse to sensitized erythrocyte can specifically be enhanced Reactivity, significantly increase Turnover of Mouse Peritoneal Macrophages phagocytosis dimethyl diaminophenazine chloride effect, directly facilitate the increasing of mouse spleen lymphocyte Reaction and mouse mixed lymphocyte reaction (MLP) are grown, mouse serum complement number and special antigen-binding cells number are increased, Identification function, phagocytic rate and the phagocytic index of macrophage are improved, and enhances mouse delayed allergy.
Fucoidin
Low weight molecular fucoidan component or piece small compared with parent molecule amount obtained from being fucoidin classification or degrading Section, Recent study show low weight molecular fucoidan there are many bioactivity, such as anticoagulation, antiviral, antithrombotic, antitumor Isoreactivity, and receive the concern of scholars.
Fucoidin can also inhibit swollen other than directly inhibiting growth of tumour cell by enhancing body immunity The growth of oncocyte is spread.Fucoidin can inhibit QGY7703 liver cancer cells to enter exponential phase in vitro, to inhibit The growth of tumour, this illustrates that the anti-tumor effect of fucoidin includes at least the approach of direct killing tumour cell.Rock algae is more Sugar in vitro can induce interleukin 1 (IL-1) and interferon gamma (IFN-γ) generation, vivo medicine-feeding can enhance T cell, The initial antibody of sheep red blood cell (SRBC) (SRBC) is answered in B cell, macrophage and natural killer cells (NK cells) function, promotion It answers.
Radix Notoginseng
A variety of saponin(es that Radix Notoginseng contains all have apparent antitumor activity, wherein being ground to the antitumor activity of Rg3 and Rh2 Study carefully more.Arasaponin (PNS) has been widely used in the cardiovascular and cerebrovasculars diseases such as treatment atherosclerosis, cerebral infarction and cerebral ischemia Disease.Notoginsenoside R is the unique component of Radix Notoginseng, has antithrombotic acitivity.Studies have found that under identical action time, people is early The apoptosis rate of young grain leukaemia cell HL-60 is increased with the increase of notoginsenoside R dosage.Selecting 300 kinds of Chinese herbal medicine needles In the experiment for carrying out vitro cytotoxicity screening to Human gastric adenocarcinoma, one of main component of arasaponin people Ginseng saponin(e Rh2 has the function of significantly inhibiting cell Proliferation and apoptosis-induced, and the total soap of existing scholar tentative confirmation Radix Notoginseng The action target spot and variation regulation and control model of glycosides are related to Bcl-2/Bax.
Sea cucumber peptide
Sea cucumber peptide be fresh and alive sea cucumbers through protease hydrolytic and it is refined after obtain based on small-molecular peptides, multiple efficacies ingredient The protein hydrolysate coexisted has good dissolubility, stability and low-viscosity.The exemplary manufacturing process of sea cucumber peptide is such as Under：Select the fresh and alive stichopus japonicus of (Dalian Changhai County) pollution-free marine site triennial or more, preprocessed, ultramicro grinding, peptide molecule enzyme Solution, sterilising and enzyme inactivating, isolate and purify, desalination, technologies are refined forms for microencapsulation spray drying etc..Product is with 3~10 ammonia Based on the low peptide of small molecule of base acid composition, component of the molecular weight less than 2000Da accounts for 90% or more, contains mucopolysaccharide, chondroitin sulfate The various trace elements such as element and calcium, iron, vanadium.
The study found that sea cucumber peptide can promote the spleen lymphocyte proliferation energy that mouse delayed allergy and ConA induce Power, can obviously increase hemolysis plaque number, the serum hemolysin of mouse, mouse macrophage to chicken red blood cell phagocytic rate, gulp down It bites index and carbonic clearance index also significantly improves.Sea cucumber peptide can promote cellular immunity and humoral immune function, enhance monokaryon macrophage The activity of cell.
In a preferred embodiment of the invention, the preparation method of sea cucumber peptide includes the following steps：
1, take new fresh sea cucumber, silt in cleaning removal intestines, cut mix, colloid mill wears into slurry, obtains sea cucumber slurries, use is triumphant Family name's nitriding measures total protein content in the sea cucumber slurries；
2, into sea cucumber slurries made from step 1 plus water, the mass ratio of the sea cucumber slurries and water is 1:1~10, adjustment Temperature is to 40~60 DEG C, and the NaOH for being 10% with mass concentration adjusts pH to 8.0~9.5, and addition accounts for the total matter of sea cucumber albumen The alkali protease (Novo protease or Carsberg protease) of amount 0.5~4.0%, stirring enzymolysis 3~6 hours, obtains sea Join enzymolysis liquid；
3, by 70~90 DEG C of heating of sea cucumber hydrolysate enzyme deactivation 15~30 minutes made from step 2；Filter (100 mesh net formula mistakes Filter), collect filtrate and centrifuge (high speed tube centrifuge, rotating speed be 10000~20000 revs/min), collect supernatant；
4, the supernatant for collecting step 3 carries out economic benefits and social benefits concentration, and it is 30~50% to be concentrated by evaporation to solid content, spray drying (150~180 DEG C of inlet air temperature, the temperature difference are 2 DEG C；70~90 DEG C of leaving air temp, the temperature difference are 1 DEG C), obtain sea cucumber Gly-His-Lys.Economic benefits and social benefits are dense Contracting device using two effect simultaneously evaporate, indirect steam is fully used and not only saves the investment of boiler, but save energy consumption, energy consumption and Single-effect concentrator is compared to reduction by 50%；For dual-effect concentrator using external heat Natural Circulation and negative pressure of vacuum mode, evaporation rate is fast, Cocnentration factor is great.Two effect concentration heating of the indirect steam supply of an effect is utilized when economic benefits and social benefits produce.
The sea cucumber peptide product obtained according to above-mentioned preparation method conforms generally to following index：
1, organoleptic attribute
The organoleptic attribute of product should meet Table A regulation.
Table A organoleptic attribute
Project Characteristic
Form It is powdered, no caking
Color and luster Milky or canescence
Impurity Without the visible exogenous impurity of twenty-twenty vision
Smell With the due smell of sea cucumber oligopeptide, free from extraneous odour
2, physical and chemical index
The physical and chemical index of the oligomeric Gly-His-Lys product of sea cucumber should meet table B regulations
Table B physical and chemical indexes
3, microbiological indicator
3.1 total plate counts, coliform index should meet table C regulations.
Table C total plate counts, coliform, mould, yeast index
Project Index
Total plate count/(CFU/g)≤ 5000
Coliform/(MPN/100g)≤ 30
Mould/(CFU/g)≤ 25
Yeast/(CFU/g)≤ 25
3.2 pathogenic bacteria indexs should meet the regulation of table D.
Table D pathogenic bacteria limit indexes
Proportioning for the present invention for each component in a kind of formulation product with tumors of nutrients treatment, does not limit especially System.In a preferred embodiment of the invention, the formulation product is by weight comprising the following terms or by following Item composition：1-50 parts of collagen (for example, 10 parts, 15 parts, 20 parts, 25 parts, 40 parts)；1-30 parts of sea cucumber peptide (for example, 5 parts, 10 Part, 15 parts, 20 parts, 25 parts)；1-30 parts of pachymaran (for example, 5 parts, 10 parts, 15 parts, 20 parts, 25 parts)；Fucoidin 1-40 Part (for example, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts)；1-40 parts of Radix Notoginseng (for example, 10 parts, 15 parts, 20 parts, 25 parts, 30 parts).
In another preferred embodiment of the present invention, the present invention is for a kind of matching with tumors of nutrients therapeutic effect Square product is only to be made of collagen, sea cucumber peptide, pachymaran, fucoidin, Radix Notoginseng, and (be immunized and live not comprising other Property) substance, the preferably described formulation product is made up of by weight：1-50 parts of collagen；1-30 parts of sea cucumber peptide；Poria cocos 1-30 parts of polysaccharide；1-40 parts of fucoidin；1-40 parts of Radix Notoginseng.
In another embodiment of the present invention, the formulation product also includes other ingredient.Preferably at one In embodiment, the formulation product also may include 1-50 parts of ginsengs, bird's nest, tremella polysaccharides, Auricularia polysaccharide, perfume (or spice) by weight Eat polysaccharide, Chinese yam polysaccharide, chitosan oligosaccharide, taurine, Radix Astragali, pollen pini, ganoderma lucidum, ganoderma lucidum polysaccharide, colostrum, spirulina, propolis, Chinese holly Qi, algal polysaccharides, swan-mussel polysaccharide or combination thereof.
In another embodiment of the present invention, the formulation product also include can on one or more drugs or food The food additives such as the adjuvant of receiving, such as sweetener, flavoring agent, stabilizer, colorant and/or pharmaceutic adjuvant.
The formulation product of the present invention can be configured to the pharmaceutical preparation of powder, particle, solution, suspension, tablet, capsule Form is formulated into beverage, dairy products, milk powder, bread, soft or boiled goods, special medicine purposes food, biscuit, noodles or generation The food form of meal product.
According to another aspect of the present invention, a kind of method preparing above-mentioned formulation product (composition) is provided, it is described Method includes：The formulation is made (for example, food in collagen, sea cucumber peptide, pachymaran, fucoidin, panax mixed Product, nutriment and drug).
Therefore, the present invention provides a kind of nutrition compound formulation formula with oncotherapy effect, and being one kind has and can have Imitate the formulation product that enhances human immunity, side effect is low, good effect and safe and non-toxic.
The present invention compound composition can be used in treat solid tumor for example gastric cancer, liver cancer, the carcinoma of the rectum, breast cancer, uterine cancer, The cancers such as vascular tumor, and can be used for preparing corresponding drug.
Embodiment
The present invention is described in detail hereinafter with reference to embodiment, the embodiment is only intended to illustrate the present invention, without It is intended to limit the scope of the invention.The scope of the present invention is specifically limited by appended claims.
In following embodiment/experiment, collagen (compound ossein) is purchased from Hubei and lattice Composite Bone collagenous biological (former company of Science and Technology Ltd.：Gongan County regent biochemistry Co., Ltd) (lot number：20160301), sea cucumber peptide is purchased from lake North and (former company of lattice Composite Bone collagenous biological Science and Technology Ltd.：Gongan County regent biochemistry Co., Ltd) (lot number： 1603105), pachymaran is purchased from the Nanjing bio tech ltd Ze Lang (lot number：160201), fucoidin buying is arrogant Even dark blue peptide science and technology research and development Co., Ltd (lot number：16020112), Radix Notoginseng is purchased from the Yunnan bio tech ltd Xiu Yantang (lot number：16031612).Unless otherwise noted, " part " refers to parts by weight.
Prepare embodiment
Embodiment 1：
In this embodiment, formulation product of the invention (composition) includes by weight：10 parts of collagen；Sea cucumber peptide 5 parts；5 parts of pachymaran；10 parts of fucoidin；10 parts of Radix Notoginseng, after being mixed according to standard preparation step make powder, Grain, liquid, tablet or capsule preparations.
Embodiment 2：
In this embodiment, formulation product of the invention (composition) includes by weight：25 parts of collagen；Sea cucumber peptide 15 parts；15 parts of pachymaran；20 parts of fucoidin；20 parts of Radix Notoginseng, after being mixed according to standard preparation step make powder, Grain, liquid, tablet or capsule preparations.
Embodiment 3：
In this embodiment, formulation product of the invention (composition) includes by weight：40 parts of collagen；Sea cucumber peptide 25 parts；25 parts of pachymaran；30 parts of fucoidin；30 parts of Radix Notoginseng, after being mixed according to standard preparation step make powder, Grain, liquid, tablet or capsule preparations.
Embodiment 4：
By establishing H22 liver cancer bearing mouse model, (Zhu Xiaofu, Zhao Yan, Cai Enbo wait Amur maples fruit small to H22 lotus knurls Tumor-inhibiting action [J] Chinese medicines of mouse, 2017,40 (8)：1935-1939), with formulation product (composition) embodiment of the present invention 3, detect its active anticancer and effect.
Take small white mouse 150, be randomly divided into blank control group, lotus knurl model group, CTX groups, test group (collagen group, Sea cucumber peptide, pachymaran, fucoidin, Radix Notoginseng group, 3 full formula group of embodiment), every group 25.To lotus knurl model group, CTX groups And three test group small white mouse forelimb oxter inoculation H22 mouse liver cells establish H22 bearing mouse models.It is daily to test group Gavage 0.5ml corresponds to formulation product, and dosage is 200mg/ (kgd), and CTX (cyclophosphamide) is injected intraperitoneally in CTX groups daily 0.5ml, dosage are 20mg/ (kgd), and blank control group and lotus knurl model group give the physiological saline of same volume, 30 are administered altogether It.After putting to death small white mouse as required, each group tumour growth situation is compared in weighing, calculates different groups of other tumour inhibiting rates.
Tumour inhibiting rate (%)=(mLotus knurl model group-mExperimental group is administered)/mLotus knurl model group* 100%
Wherein mLotus knurl model groupFor lotus knurl model group tumor quality, mExperimental group is administeredThe respectively CTX groups of experimental drug, collagen group, Sea cucumber peptide, pachymaran, fucoidin, Radix Notoginseng group, the tumor quality of 3 full formula group of embodiment.
Experimental results are as follows：
* compared with lotus knurl model group, P < 0.05
The above result shows that compared with lotus knurl model group group, CTX groups, collagen group, sea cucumber peptide, pachymaran, rock algae The tumor quality of polysaccharide, Radix Notoginseng group, 3 full formula group of embodiment has significant decrease (P < 0.05), shows the raw material that the present invention selects And inventive formulation product (composition) can adjust small white mouse body immunity, play the effect for inhibiting tumour growth；Together When 3 full formula group of embodiment test result and collagen group, sea cucumber peptide, pachymaran, fucoidin, Radix Notoginseng group contrast table Bright, the raw material that inventive formulation product (composition) is selected is to inhibiting tumour growth to have good synergistic function.
Embodiment 5：
Product embodiments 3 of the present invention are clinically tested, as a result, it has been found that product of the present invention is to gastric cancer, liver cancer, rectum The prevention of cancer, breast cancer, uterine cancer, vascular tumor etc. has remarkable result.Model case has：
Case one：Wen Xiujuan, female 48 years old, start often to feel nausea in stomach, and with Upper abdominal pain, food for 2014 It is intended to decline, the symptoms such as breathes hard, goes to hospital to check and be diagnosed as gastric cancer mid-term (tumor size 1.2*1.6cm), but she is unwilling Operation excision and chemotherapy are carried out, takes product of the present invention (daily 15g) after being introduced, appetite increases after 1 year, and body also has Strength, nausea and vomiting phenomenon have not existed yet, and tumor size is reduced into 0.75*1.03cm, and tumor size is reduced into after 2 years 0.48*0.61cm。
Case two：Wang Lianying, female 60 years old, occur liver discomfort, pain, weak and hemorrhage of digestive tract etc. of becoming thin for 2014 Uncomfortable symptom checks to be liver cancer mid-term (tumor size 3.2*2.8cm) through hospital, takes product of the present invention after being introduced (daily 15g), liver pain symptom disappears after half a year, and diet also increased, and spirit gradually improves；Tumour is big after taking 1 year Small to be reduced into 1.95*2.5cm, tumor size is reduced into 1.12*0.98cm after 2 years.
Case three：Zhang Haoyang, man, 53 years old, start at the beginning of 2015 to have difficulty in passing one's motions, it is even have blood in stool, do not feel like eating, arrive hospital afterwards Inspection is diagnosed as the carcinoma of the rectum (tumor size 2.5*2.1), and thinks no longer to fit with illnesss, hospitals such as prostatitis and hepatomegaly Closing surgical resection therapy can only go home.Start to take product of the present invention (daily 15g) after being introduced, appetite is just felt after half a year It increases, stool is no longer difficult, and prostatitis and hepatomegaly symptom make moderate progress.After 1 year, tumor size is reduced into 1.58* 1.32cm, tumor size is reduced into 0.82*0.67cm after 2 years.
Case four：Li Guizhi, female, 42 years old, the patient feels left breast is uncomfortable at the beginning of 2015 had big lump, nipple recessed It falls into, and often feels swelling pain.After hospital is diagnosed as breast cancer (tumor size 1.5*1.1cm), she is unwilling to carry out hand Art is cut off and chemotherapy.Product of the present invention (daily 15g) is taken after being introduced, and tumor size is reduced into 0.95* after taking 1 year 0.72cm, tumor size is reduced into 0.52*0.39cm after 2 years.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of nutrition formula product with oncotherapy function, wherein the formulation product includes by weight：Collagen 1-50 parts of albumen；1-30 parts of sea cucumber peptide；1-30 parts of pachymaran；1-40 parts of fucoidin；With 1-40 parts of Radix Notoginseng.
2. formulation product according to claim 1, wherein the formulation product includes by weight：Collagen 30- 50 parts；15-30 parts of sea cucumber peptide；15-30 parts of pachymaran；15-30 parts of fucoidin；With 25-40 parts of Radix Notoginseng.
3. formulation product according to claim 1 or 2, wherein the collagen is I-type collagen, II Collagen Type VI eggs (compound ossein), type III collagen or their mixture in vain, and/or (such as chicken cartilage, fish is soft from biological cartilage Bone, ox cartilage, pig cartilage and other biological cartilages), fish scale, animal skin (such as fish-skin, pigskin, ox-hide and other biological skins Skin), biological tendon tissue, bone extraction collagen, ossein, bone collagen, bone collagen peptide, collagen obtained Peptide, I-type collagen, II collagen types (compound ossein), type III collagen, gartilage powder or combination thereof.
4. formulation product according to any one of claim 1 to 3, wherein the Radix Notoginseng is selected from the group being made up of： Sanchi flower, Roots of Panax Notoginseng, Radix Notoginseng palpus, Radix Notoginseng stem, sanchi leaf and the polysaccharide extracted from them, saponin(e or other extracts or it Combination, preferably Roots of Panax Notoginseng or Radix Notoginseng stem.
5. formulation product according to any one of claim 1 to 4, wherein the pachymaran is from Poria cocos powder, Fu Siberian cocklebur extract or su-fuling.
6. formulation product according to any one of claim 1 to 5, wherein the sea cucumber peptide is carried from sea cucumber powder or sea cucumber Object is taken, and can further contain sea cucumber polysaccharide, chondroitin sulfate, trace element or combinations thereof.
7. formulation product according to any one of claim 1 to 6, wherein the fucoidin is derived from selected from by following The group of composition：Rock algae powder, rock algae extract or combination thereof.
8. formulation product according to any one of claim 1 to 7, wherein the formulation product can also wrap by weight Containing 1-50 parts of ginseng, bird's nest, tremella polysaccharides, Auricularia polysaccharide, mushroom polysaccharide, Chinese yam polysaccharide, chitosan oligosaccharide, taurine, Radix Astragali, pine Pollen, ganoderma lucidum, ganoderma lucidum polysaccharide, colostrum, spirulina, propolis, matrimony vine, algal polysaccharides, swan-mussel polysaccharide or combination thereof, also Including the food additives such as one or more sweeteners, flavoring agent, stabilizer, colorant and/or pharmaceutic adjuvant.
9. formulation product according to any one of claim 1 to 8 can be configured to powder, particle, solution, suspension Liquid, tablet or capsule pharmaceutical dosage form or be formulated into bread, soft or boiled goods, special medicine purposes formula food, drink Material, dairy products, milk powder, biscuit, noodles or the food form for meal product.
10. a kind of method preparing formulation product according to any one of claim 1 to 9, the method includes：By institute It states collagen, sea cucumber peptide, pachymaran, fucoidin and panax mixed and the formulation is made (for example, food, health care Food, nutriment and drug).
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Application publication date: 20181113