CN108783438B

CN108783438B - Soybean protein isolate low-residue total-nutrient formula product, preparation method and application thereof

Info

Publication number: CN108783438B
Application number: CN201810715869.2A
Authority: CN
Inventors: 冯予春; 覃倩倩; 刘德恽; 陈璐璐
Original assignee: Jilin Maifu Nutrition Technology Co ltd; Maifu Nutrition Technology Beijing Co Ltd
Current assignee: Beijing Maifu Medical Technology Co ltd; Jilin Maifu Nutrition Technology Co ltd; Maifu Nutrition Technology Co ltd
Priority date: 2018-07-03
Filing date: 2018-07-03
Publication date: 2022-03-29
Anticipated expiration: 2038-07-03
Also published as: CN114468283B; CN108783438A; CN114468283A

Abstract

The invention provides a low-residue total-nutrient formula product, a preparation method and application thereof, wherein the product is not added with dietary fiber and is suitable for intestinal examination and intestinal surgery patients needing preparation for intestinal cleaning. The product contains protein, carbohydrate, fat, mineral substances and vitamins, removes food-derived gas production components, has extremely low residues, is rich in nutritional components and easy to absorb, and can provide sufficient nutrition for patients while cleaning and reducing gas production in intestinal tracts. Compared with the conventional intestinal tract cleaning treatment mode, the intestinal tract cleanliness is high after the product is treated, the detection rate of intestinal adenoma and polyp is high, the gas production is low, the nutrition support is good, and the patient suitability is high.

Description

Soybean protein isolate low-residue total-nutrient formula product, preparation method and application thereof

Technical Field

The invention relates to a low-slag total nutrient formula product for special medicine, a preparation method and application thereof.

Background

Colorectal cancer, colorectal polyps are high-risk, high-morbidity types of intestinal lesions.

Colorectal cancer is a malignant tumor originating in the epithelium of the colorectal mucosa and is one of the most common clinical malignant tumors. More than 25 ten thousand new cases of colorectal cancer occur in China each year. According to the annual report of Chinese tumor registration, colorectal cancer is the second most common digestive tract tumor in 2009 in the tumor registration area of China, is second only to gastric cancer, has the morbidity of 29.44/10 ten thousand, has the contemporary mortality of 14.23/10 ten thousand and accounts for the 5 th position of the mortality of malignant tumors. In recent 20 years, the incidence of colorectal cancer in China is in a continuous rising trend, the incidence of colorectal cancer is obviously increased, and the rectal cancer is basically stable. At present, the incidence and death of colorectal cancer in China account for 18% -20% of the same period in the world.

The colorectal cancer is one of common malignant tumors in China, and the vast majority of colorectal cancers are generally considered to originate from adenoma cancer, and part of colorectal cancers directly originate from stem cells of the germinal center of the normal mucosa of the large intestine, namely denove cancer, such as IIc lesion and the like.

Colorectal polyps refer to all lesions that bulge into the intestinal lumen. The incidence of colorectal polyps is different from country to country, and the total enteroscope detection rate is 10-20%. The incidence increases with age, with adenomatous polyps being the most common, accounting for about 70%. Intestinal polyps, if left undetected and treated for long periods of time, can lead to hematochezia and stool abnormalities, intussusception, prolapse of the bowel, and even carcinogenesis.

Therefore, timely and accurate diagnosis and treatment of the intestinal diseases are needed. With the popularization of the clinical application of the digestive endoscopy technology, the endoscopy forms such as colonoscopes, enteroscopes and capsule endoscopes increasingly play a prominent role in the diagnosis and treatment of intestinal diseases. The screening means represented by the colonoscope can effectively prevent the colorectal cancer from happening, and the fatality rate of the colorectal cancer is reduced by 53 percent compared with the expected fatality rate. In the united states, total colonoscopy has become the first tool to screen colorectal cancer in the white population above the age of 50. Meanwhile, colonoscopy is also the most powerful examination means for diagnosing colonic polyps. In the diagnosis of the colorectal cancer, endoscopy also has the advantages that various imaging can not replace the existing imaging, the early-stage lesion of the mucosa of the large intestine can be visually found, the histological evaluation of the lesion can be carried out by biopsy, and the detection rate and the diagnosis rate of early-stage cancer and precancerous lesion can be further improved.

In endoscopy, the preparation quality of the intestinal tract directly influences the diagnosis and treatment effect of the endoscope. Taking a colonoscope as a representative, 2 key indexes of the colonoscopy quality are the cecal intubation rate and the adenoma detection rate, which are related to the intestinal clearance quality. The intestinal tract preparation quality is a key determining factor of the quality, difficulty, speed and completeness of the colonoscope, the diagnosis accuracy and treatment safety of the colonoscope are determined, and the intestinal tract clearing sufficiency degree is important for the colonoscopy effect.

The problem of poor endoscope effect caused by insufficient intestinal tract preparation is prominent for a long time. Statistically, the proportion of inadequate intestinal tract preparation is 20% to 30% (HarewoodgC, Sharma VK, degarro P.Gastrointest Endosc, 2003, 58 (1): 76-79.Hassan C, et al; European Society of gastroenterological Endospy, 2013, 45 (2): 142-150.Liu X, Luo H, Zhang L, et al.Gut, 2014, 63 (1): 125- & 130.). The consequences of inadequate bowel preparation are:

(1) the lesions are missed. Patients with inadequate bowel preparation had a 3-fold increased risk of polyps and adenoma misses (Hong SN, Sung IK, Kim JH, et al. Clin Endosc, 2012, 45 (4): 404-411.).

(2) The enteroscopy was repeated. Patients with inadequate bowel preparation have a significantly increased rate of endoscopic failures requiring repeated bowel cleansing (Chokshi RV, et al.

(3) The enteroscopy procedure time increases. Colonoscopic procedure time (time to cecum, enteroscopic withdrawal time, total procedure time) is significantly correlated with bowel cleansing quality. Colonoscope procedures with low bowel clearance quality were significantly longer than those with medium and high bowel clearance (16.1, 14.4, 11.9 minutes to cecum; 11.3, 11.1, 9.8 minutes to enteroscope; 27.4, 25.6, 21.7 minutes to total procedure time) (Froehlich F, Wietlisbach V, Gonvers JJ, et al. Gastrointest Endosc, 2005, 61 (3): 378-384.).

(4) Difficulty in enteroscopy is increased. Insufficient preparation of the intestine leads to an increase in the operational difficulty of 21.8%: the colonoscope with low bowel clearing quality has a significantly higher difficult operation rate than those with high bowel clearing quality and medium bowel clearing quality; the difficulty of colonoscopy was increased by 21.8% compared to those with high bowel clearance, the differences being statistically significant (Froehlich F, Wietlisbach V, Gonvers JJ, et al. Gastrointest Endosc, 2005, 61 (3): 378-384.).

(5) Enteroscopy procedures are often not completed. Insufficient bowel preparation results in a 19.3% decrease in the completion rate of colonoscopic procedures: the colon endoscope operation completion rate with low bowel clearing quality is obviously lower than that of the colon endoscope with high bowel clearing quality and the middle bowel clearing quality; the colonoscopic performance completion rate decreased by 19.3% compared to those with high bowel clearance quality, with statistical differences (Froehlich F, Wietlisbach V, Gonvers JJ, et al. Gastrointest Endosc, 2005, 61 (3): 378-384.).

(6) The inspection cost increases. Inadequate bowel preparation results in increased costs for endoscopy, which are 11.8% and 21.5% for private and public hospitals, respectively, compared to colonoscopy under ideal bowel preparation conditions. (Rex DK, Imperial TF, Latinovich DR, et al. am Jgastroentol, 2002, 97 (7): 1696-.

Therefore, from the perspective of enteroscopy diagnosis, the degree of intestinal tract cleanliness is of great significance for accurate diagnosis and treatment.

From the viewpoint of enteropathy operation treatment, preoperative preparation for cleaning intestinal tract is also very important for the smooth implementation of intestinal tract operation. The preoperative intestinal tract preparation can remove excrement in the intestinal tract, reduce the number of bacteria in the intestinal tract and reduce the occurrence of complications such as anastomotic fistula, abdominal infection, wound dehiscence and the like.

In conclusion, the importance of intestinal tract cleaning is not negligible in the enteroscope diagnosis and treatment stage and the intestinal tract operation treatment stage. Currently used bowel preparation methods include enema and oral laxative methods (e.g., mannitol, magnesium sulfate, electrolyte liquids, senna leaves, etc.). These methods have been satisfactory for most patients with colorectal cancer surgery, but have drawbacks and deficiencies. Because the enema method or oral cathartic will bring electrolyte disorder, nutrient loss is serious, patient experience is bad and so on problem, and require 3 days before the enema and oral cathartic to restrict diet, will cause protein, vitamin, mineral substance and so on various nutrient and energy intake insufficient, thus influence tissue repair and wound healing, weaken the ability of defending infection. Meanwhile, the organism is in a hungry state within 3 days, so that the intestinal mucosa of a patient is atrophied, the barrier function of the mucosa is damaged, the flora is disordered, the incidence rate of intestinal bacteria displacement is increased, and the intestinal infection chance is increased. The absorption function of the intestinal mucosa is weakened, so that nutrient absorption disorder or electrolyte imbalance is caused, and water loss and malnutrition occur under the influence of diseases, so that the tolerance of a patient to the operation is weakened.

In order to solve the problems, at present, before enema or oral laxatives, intestinal nutrition preparations or common liquid diet is generally used as auxiliary measures for intestinal preparation clinically to supply the requirements of patients for nutrition. However, current enteral nutrition preparations do not meet the demand, solving the problem, because:

(1) the nutrient components are not comprehensive, and the comprehensive nutritional support can not be exerted.

For example, CN105795481A discloses a nutritional supplement dedicated for intestinal preoperative use, which contains maltodextrin, glutamine and sodium potassium ions. The formula has single nutrient component, is lack of vitamins, minerals and fat, and is incomplete in nutrition supply.

(2) The cellulose content is not low enough, and the cleanliness of the intestinal tract can not meet the requirement.

For example, CN107951015A discloses a total nutrient formula powder and a preparation method thereof, wherein the formula contains dietary fiber, and is not suitable for intestinal tract cleaning preparation. CN103431391A discloses a comprehensive nutritional powder formulation, which contains corn fiber powder, and is not suitable for intestinal tract cleaning preparation.

(3) Is not easy to absorb, is easy to cause intestinal gas production and flatulence, increases intestinal bubbles and improves the difficulty of enteroscopy operation.

For example, CN1290443C describes an enteral total nutrient emulsion which is mainly suitable for patients with nutrient intake disorder, whose protein component is mainly from casein preparation with slow absorption and high cost, and whose nutrient substances are not easy to be absorbed and are easy to produce flatulence.

Disclosure of Invention

Aiming at the defects of the prior art, the invention prepares a low-slag total-nutrient formula product specially suitable for intestinal microscopic examination, intestinal preoperative preparation and postoperative recovery through research. The product (1) has extremely low cellulose content and good intestinal tract cleaning effect, can improve the success rate of enteroscopy, effectively avoids missed diagnosis and repeated examination, and reduces the cost; (2) particularly, food source components of flatulence are removed, intestinal flatulence is effectively avoided, bubble generation in enteroscopy is reduced, and intestinal detection accuracy is improved; (3) the protein which is easier to be absorbed by the body is selected, the nutrition formula is scientific and comprehensive, the patient experience is good, the adverse reaction is less, and the postoperative recovery is fast.

Specifically, the present invention relates to:

(1) a low-slag total-nutrient formula product is characterized by comprising the following components: proteins, carbohydrates, fats, vitamins and minerals.

(2) The low-residue total nutrient formula product in the (1) has the dietary fiber content of less than 1.58g per 100g of the product.

(3) The low residue total nutrient formulation of (1) or (2) above, wherein the protein is soy protein isolate and/or rice protein.

(4) The low-slag total nutrient formula product of any one of the items (1) to (3) contains 150 g of the soybean protein isolate and 250g of the rice protein and/or 20 to 40g of the rice protein per 1000g of the product.

(5) The low profile total nutritional formula of any one of (1) to (4) above, wherein the carbohydrate is maltodextrin and/or fructose.

(6) The low-slag total nutrient formula product of any one of the items (1) to (5) above, wherein each 1000g of the product contains 70-130g of maltodextrin and/or 150-300g of fructose.

(7) The low profile full nutritional formula of any one of (1) to (6) above, wherein the fat is at least 2 selected from the group consisting of corn oil, sunflower oil, soybean oil, rapeseed oil, coconut oil and medium chain triglycerides.

(8) The low-slag total nutrient formula product of any one of the items (1) to (7) contains 400g of the fat 230-400g per 1000g of the product.

(9) The low sediment full nutritional formula of any one of (1) to (8) above, wherein the fat is provided by a low protein fat powder.

(10) The low-slag total nutrient formula product in the above (9) contains 400g of the low-protein fat powder 230-.

(11) The low sediment full nutritional formula of any one of (1) to (8) above, wherein the fat is blended with a fat blend of 4-6: 2-4 mass ratio of vegetable oil and fat and medium chain triglyceride.

(12) The low residue total nutrient formulation of (11) above, wherein the vegetable oil comprises corn oil, sunflower oil, soybean oil, rapeseed oil, and coconut oil.

(13) The low residue total nutrient formula preparation of (12) above, wherein the mass ratio of the corn oil, the sunflower seed oil, the soybean oil, the rapeseed oil and the coconut oil is 28-32:18-22:18-22:18-22: 6-9.

(14) The low profile total nutrient formulation of any one of (1) to (13) above, wherein the vitamin is at least 2 selected from the group consisting of sodium L-ascorbate, niacinamide, folic acid, dl-alpha-tocopherol acetate, D-calcium pantothenate, riboflavin, pyridoxine hydrochloride, thiamine hydrochloride, retinyl acetate, cholecalciferol, phytomenadione, cyanocobalamine, and D-biotin.

(15) The low residue total nutrient formula product of (14) above, wherein per 1000g of the product, the vitamin contents are as follows: sodium L-ascorbate: 0.8-2g, nicotinamide: 0.1-0.25g, folic acid: 0.001-0.003g, dl- α -tocopheryl acetate: 0.23 to 0.55g, calcium D-pantothenate: 0.05-0.12g, riboflavin: 0.09-0.22g, pyridoxine hydrochloride: 0.15-0.34g, thiamine hydrochloride: 0.01-0.028g, retinyl acetate: 0.03-0.07g, cholecalciferol: 0.015-0.034g, menadione: 0.0004-0.0009g, cyanocobalamin: 0.00004-0.00009g, D-biotin: 0.00007-0.00018 g.

(16) The low residue total nutrient formulation of any one of (1) to (15) above, wherein the minerals are at least 2 selected from the group consisting of ferrous sulfate, zinc sulfate, magnesium sulfate, manganese sulfate, potassium iodate, copper sulfate, sodium selenite, potassium citrate, sodium citrate, potassium chloride, calcium hydrogen phosphate, sodium chloride and calcium carbonate, and preferably these minerals are encapsulated with an encapsulating agent.

(17) The low residue total nutrient formula product of (16) above, wherein per 1000g of the product, the contents of the minerals are as follows: 0.08-0.25g of ferrous sulfate, 0.08-0.22g of zinc sulfate, 7-17g of magnesium sulfate, 0.01-0.04g of manganese sulfate, 0.0009-0.0023g of potassium iodate, 0.003-0.009g of copper sulfate, 0.0003-0.0007g of sodium selenite, 15-32g of potassium citrate, 5-7.8g of sodium citrate, 9-14g of potassium chloride, 2.8-5g of calcium hydrophosphate, 2.4-5g of sodium chloride and 1-3g of calcium carbonate.

(18) The low residue total nutrient formulation of any one of (1) to (17) above, further comprising a food additive.

(19) The low sediment full nutritional formulation of (18) above, wherein the food additive is sodium carboxymethyl cellulose as a thickener.

(20) The low residue total nutrient formulation (19) described in (1) above, which contains 1-18g of said sodium carboxymethylcellulose per 1000g of said formulation.

(21) The low sediment full nutritional formula of any one of (1) to (20) above, wherein the protein is soy protein isolate and/or rice protein; the carbohydrate is maltodextrin and/or fructose; the fat is at least 2 selected from the group consisting of corn oil, sunflower oil, soybean oil, rapeseed oil, coconut oil, and medium chain triglycerides; the vitamins are at least 2 selected from the group consisting of sodium L-ascorbate, nicotinamide, folic acid, dl-alpha-tocopherol acetate, calcium D-pantothenate, riboflavin, pyridoxine hydrochloride, thiamine hydrochloride, retinyl acetate, cholecalciferol, phytomenadione, cyanocobalamin, and D-biotin; the mineral is at least 2 selected from ferrous sulfate, zinc sulfate, magnesium sulfate, manganese sulfate, potassium iodate, copper sulfate, sodium selenite, potassium citrate, sodium citrate, potassium chloride, calcium hydrogen phosphate, sodium chloride and calcium carbonate; the nutritional formula optionally further comprises a food additive.

(22) The low profile nutritionally complete formula according to (21) above, which comprises soy protein isolate, rice protein, maltodextrin, fructose, corn oil, sunflower seed oil, soybean oil, canola oil, coconut oil, medium chain triglycerides, sodium L-ascorbate, niacinamide, folic acid, dl-alpha-tocopherol acetate, calcium D-pantothenate, riboflavin, pyridoxine hydrochloride, thiamine hydrochloride, retinyl acetate, cholecalciferol, phytomenadione, cyanocobalamin, D-biotin, ferrous sulfate, zinc sulfate, magnesium sulfate, manganese sulfate, potassium iodate, copper sulfate, sodium selenite, potassium citrate, sodium citrate, potassium chloride, calcium hydrogen phosphate, sodium chloride, calcium carbonate, and optionally additional food additives such as sodium carboxymethylcellulose.

(23) The low-residue total nutrient formula product of (22) above comprises, per 1000g of the product, 150-250g of soybean protein isolate, 20-40g of rice protein, 70-130g of maltodextrin, 300g of fructose 150, 400g of fat 230, 0.8-2g of sodium L-ascorbate, 0.1-0.25g of nicotinamide, 0.001-0.003g of folic acid, 0.23-0.55g of dl-alpha-tocopherol acetate, 0.05-0.12g of D-calcium pantothenate, 0.09-0.22g of riboflavin, 0.15-0.34g of pyridoxine hydrochloride, 0.01-0.028g of thiamine hydrochloride, 0.03-0.07g of retinyl acetate, 0.015-0.034g of cholecalciferol, 0.0004-0.0009g of phytomenadione, 0.00004-0.00009g of cyanocobalamine, 0.00009g of D-0.7-00018.08 g of ferrous sulfate, 0.18g of ferrous sulfate, 0.08-0.22g of zinc sulfate, 7-17g of magnesium sulfate, 0.01-0.04g of manganese sulfate, 0.0009-0.0023g of potassium iodate, 0.003-0.009g of copper sulfate, 0.0003-0.0007g of sodium selenite, 15-32g of potassium citrate, 5-7.8g of sodium citrate, 9-14g of potassium chloride, 2.8-5g of calcium hydrophosphate, 2.4-5g of sodium chloride, 1-3g of calcium carbonate and 1-18g of optional thickener carboxymethylcellulose sodium; preferably, the fat comprises vegetable oil and fat and medium chain triglycerides, and the vegetable oil and fat is composed of corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil.

(24) The low residue total nutrient formula product of (23) above, wherein the mass ratio of vegetable fat to medium chain triglycerides is 4-6: 2-4, wherein the mass ratio of the corn oil, the sunflower seed oil, the soybean oil, the rapeseed oil and the coconut oil is 28-32:18-22:18-22:18-22: 6-9.

(25) The low-residue total nutrient formula product of (23) or (24) above, wherein each 1000g of the product comprises 210g of soybean protein isolate 170-, 0.1-0.2g of zinc sulfate, 11-15g of magnesium sulfate, 0.01-0.03g of manganese sulfate, 0.001-0.0022g of potassium iodate, 0.004-0.007g of copper sulfate, 0.0003-0.0006g of sodium selenite, 18-27g of potassium citrate, 5.5-7.5g of sodium citrate, 10-12g of potassium chloride, 3.2-4.5g of calcium hydrophosphate, 2.6-4.5g of sodium chloride, 1.3-2.8g of calcium carbonate and 3-15g of carboxymethyl cellulose sodium which is an optional additive.

(26) The low-residue total nutrient formulation product of any one of (23) to (25) above, which contains, per 1000g of the product, 200-210g of soybean protein isolate, 28-33g of rice protein, 100g of maltodextrin, 240g of fructose-containing protein, 345g of fat-containing 330, 1.0-1.3g of sodium L-ascorbate, 0.18-0.2g of nicotinamide, 0.0017-0.002g of folic acid, 0.35-0.45g of dl-alpha-tocopherol acetate, 0.07-0.08g of D-calcium pantothenate, 0.1-0.14g of riboflavin, 0.2-0.25g of pyridoxine hydrochloride, 0.012-0.02g of thiamine hydrochloride, 0.04-0.05g of retinyl acetate, 0.02-0.03g of cholecalciferol, 0.0005-0.6 g of phytomenadione, 0.00005-0.00006g of cyanocobalamin, 0.00006g of D-0.0000.0001 g of ferrous sulfate, 0.0001-0.0001 g of biological sulfate, 0.0001-0.0001 g of L-0.0001, 0.15-0.18g of zinc sulfate, 13-14g of magnesium sulfate, 0.01-0.02g of manganese sulfate, 0.001-0.002g of potassium iodate, 0.004-0.007g of copper sulfate, 0.0003-0.0006g of sodium selenite, 20-27g of potassium citrate, 6-7.2g of sodium citrate, 10-12g of potassium chloride, 3.5-4.2g of calcium hydrophosphate, 2.8-4.2g of sodium chloride, 1.5-2.4g of calcium carbonate and 4-14g of carboxymethyl cellulose sodium which is an optional additive.

(27) The method for preparing a low-slag total nutrient formulation as described in any one of (1) to (26) above, comprising the steps of: (1) pretreatment, (2) weighing, (3) crushing and screening, (4) primary mixing, and (5) total mixing.

(28) The method according to (27) above, wherein the pretreatment step of step (1) is carried out by irradiating each of the raw materials and the optional food additive for 2 hours for sterilization.

(29) The method according to (27) or (28) above, wherein the pulverizing and sieving in step (3) is carried out by sieving each raw material and optionally the food additive through a sieve of 100 mesh or more.

(30) The process of any one of (27) to (29) above, wherein the preliminary mixing in step (4) is carried out under the conditions: various vitamins, various minerals, rice protein and optional food additives such as sodium carboxymethyl cellulose are primarily mixed for 10-20 min according to the weighed amount in the environment with the temperature not higher than 28 ℃ and the humidity not more than 65% until the mixture is uniform.

(31) The process of any one of (27) to (30) above, wherein the conditions of the total mixing in the step (5) are: and (3) adding the maltodextrin, the soybean protein isolate, the fructose and the fat into the primary mixed material obtained in the step (4) according to the weighed amount, and mixing for 20-40 min, preferably 30min, in an environment with the temperature not higher than 28 ℃ and the humidity not higher than 65% until the mixture is uniform.

(32) Use of a low-residue total nutrient formulation according to any one of (1) to (26) above in the preparation of an enteral cleanser.

(33) Use of the low residue total nutrient formulation of (32) above in the preparation of a preparation for bowel cleansing.

(34) The use of (32) or (33) above, wherein the bowel cleaning preparation is a bowel cleaning preparation prior to colonoscopy, duodenoscopy, sonoendoscopy or capsule endoscopy.

(35) The use of (32) or (33) above, wherein the bowel cleansing preparation is a bowel cleansing preparation prior to bowel surgery.

(36) The use of (35) above, wherein the surgical procedure comprises a large intestine cancer procedure, a colorectal cancer radical treatment procedure, a total colectomy, a laparoscopic gastrointestinal tract procedure, a pancreaticoduodenal resection, a small intestine wide resection procedure, a small intestine partial resection procedure, and an intestinal stoma (fistula) closure procedure.

(37) The use of any one of (32) to (36), wherein the preparation for gut cleansing is to eat the low-residue total nutrient formulation as three meals, namely morning, noon and evening, with a meal dosage of 180 g.

(38) Use of a low-profile total nutrient formulation according to any one of (1) to (26) above in nutritional support following intestinal surgery.

(39) The use of (38) above, wherein the intestinal surgery comprises colorectal cancer surgery, colorectal cancer radical surgery, total colectomy, laparoscopic gastrointestinal tract surgery, pancreaticoduodenal resection, small intestine wide resection, small intestine partial resection, and intestinal stoma (fistula) closure.

Detailed Description

In a first aspect, the present invention provides a low-residue total nutrient formulation for use in the preparation of gut cleansing, said formulation comprising the following components: proteins, carbohydrates, fats, vitamins and minerals.

In the invention, the contents of the components fully consider the special low-slag, easy-absorption and comprehensive nutritional requirements of special people who need to carry out intestinal tract cleaning preparation on food.

The above components are explained in order below.

(A) protein

In a preferred embodiment, the protein in the preparation of the invention comprises soy protein isolate of vegetable origin and/or rice protein.

In the prior art, animal protein casein is commonly used as protein, but casein is difficult to be absorbed by the body. The two high-quality proteins selected by the invention are all pure natural vegetable proteins, are easier to absorb and simultaneously reduce the product cost.

The soybean protein isolate is a complete protein food produced by using low-temperature desolventizing soybean meal as a raw material. The isolated soy protein has a protein content of above 90%, and approximately 20 kinds of amino acids, and contains essential amino acids for human body. It has rich nutrition, low fat content, no cholesterol, and healthier nutritional structure.

In the present invention, soy protein isolate is selected as the primary protein source rather than the common soy protein/soy protein concentrate. The common soybean (concentrated) protein contains oligosaccharide alpha-D-galactoside substances which are easy to generate gas, mainly stachyose and raffinose, and the two substances belong to water-soluble dietary fibers and are easy to generate gas. The soybean protein isolate selected by the invention is a protein substance with oligosaccharide aerogenesis factors removed, and the content of water-soluble dietary fiber is lower than the lower detection limit. Therefore, the invention selects the isolated soy protein as the main protein source, and can reduce intestinal flatulence caused by food-derived gas production, thereby effectively reducing bubble generation during intestinal microscopic examination, being beneficial to recovery after meat resting surgery, improving microscopic examination quality and promoting postoperative healing.

In the present invention, rice protein may be used as the protein. The biological value (B.V.) and the protein value (P.V.) of the rice protein are higher than those of other proteins, the nutritional value is high, the amino acid composition of the rice protein is balanced and reasonable, the amino acid content is high, the rice protein is easy to absorb, and the rice protein is incomparable with other proteins, and is particularly suitable for people with poor intestinal digestion and absorption functions and high nutritional requirements. In addition, the rice protein is a low-antigen type protein, does not cause allergic reaction, and is therefore suitable for infants and allergic patients. Meanwhile, the rice protein not only has unique nutritional function, but also has other health care functions, such as reducing the content of serum cholesterol.

In a more preferred embodiment, the nutritional formula product of the invention is prepared by simultaneously using isolated soy protein and rice protein, and the design of the double-protein formula ensures that the nutrition of the protein in the formula is more comprehensive and balanced, is particularly suitable for intestinal tract to be examined and operated patients with poor digestion and absorption, and has certain health care function while providing intestinal tract cleaning preparation and nutritional support.

Preferably, the low-slag total nutrient formula product contains 150-250g of the soybean protein isolate, more preferably 170-210g, and even more preferably 200-210g per 1000 g.

Preferably, the low-profile total nutritional formula of the present invention comprises between 20 and 40g of rice protein per 1000g, more preferably between 26 and 33g, even more preferably between 28 and 33 g.

(di) carbohydrates

In the low-profile total nutritional formula of the present invention, the carbohydrate is preferably maltodextrin and/or fructose.

Preferably, the low-slag total nutrient formula of the invention contains 70-130g of maltodextrin per 1000g, more preferably 95-120g, and still more preferably 100-118 g.

Preferably, each 1000g of the low-slag total nutrient formula product contains 150-300g of fructose, more preferably 225-250g, and even more preferably 230-240 g.

(III) fats

In a preferred embodiment, the fat used in the low-sediment total nutritional formula of the present invention comprises at least 2 of the following ingredients: corn oil, sunflower oil, soybean oil, rapeseed oil, coconut oil, and medium chain triglycerides.

In a more preferred embodiment, the fat preferably comprises vegetable fats and oils and medium chain triglycerides in a mass ratio of 4-6: 2-4, more preferably 5: 3. the vegetable oil and fat can be composed of corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil according to the mass ratio of 28-32:18-22:18-22:18-22:6-9, and the more preferable mass ratio is 31:21.5:20:19: 8.5.

In a further preferred embodiment, a low protein fat powder is preferably used as the fat source, more preferably a low protein fat powder with a high content of long chain unsaturated fatty acids (linoleic and alpha-linolenic acid), e.g. more than 24% by mass of long chain unsaturated fatty acids based on the total fatty acids, which allows for a far higher content of long chain unsaturated fatty acids than in other enteral nutritionals for the low-slag nutritionals formula of the invention. Such a low-protein fat powder is commercially available, and is available from, for example, Meitai science and technology (Qingdao) Co.

Linoleic acid contains 2 unsaturated fat bonds, and has physiological functions of resisting cancer, resisting atherosclerosis, enhancing immunity, inhibiting fat accumulation, reducing weight, reducing cholesterol, promoting growth and development, etc. Alpha-linolenic acid is a basic substance forming human tissue cells and biological enzymes, can be synthesized, metabolized and converted into vital active factors DHA and EPA necessary for the organism in vivo, and the two substances can reduce blood fat, improve blood circulation, inhibit platelet aggregation and inhibit atherosclerotic plaque and thrombosis in vivo. Linoleic acid and alpha-linolenic acid are essential fatty acids that the human body cannot synthesize by itself and require food-borne supply. In the optimized nutritional formula product, the low-protein fat powder with high linoleic acid and alpha-linolenic acid contents is added as a fat nutrient source, so that the nutritional structure of the product is healthier, and the using population is wider.

Preferably, each 1000g of the low-slag total nutrient formula product comprises 400g of fat 230-.

When the low-protein fat powder is used as the fat nutrient source, the low-slag total nutrient formula product contains 400g of the low-protein fat powder 230-.

(IV) vitamins

In a preferred embodiment, the vitamins in the low-profile total nutritional formula of the present invention comprise at least 2 of the following ingredients: sodium L-ascorbate, nicotinamide, folic acid, dl-alpha-tocopherol acetate, D-calcium pantothenate, riboflavin, pyridoxine hydrochloride, thiamine hydrochloride, retinyl acetate, cholecalciferol, phytomenadione, cyanocobalamine, and D-biotin.

The vitamin of the invention contains at least 2 vitamins required by human body, can help intestinal tract surgery patients with intestinal tract dysfunction to recover, can improve the immunity of the organism, protect and repair epithelial cells, and supplement B vitamins which are easy to lose in surgery or trauma, such as vitamin B1, B2, nicotinic acid and pantothenic acid, thereby improving the physical function. The invention strictly calculates the dosage and the limited quantity of the vitamin and scientifically mixes the vitamin.

Preferably, in every 1000g of the low-residue total nutrient formula product, the contents of the vitamins are respectively as follows:

sodium L-ascorbate: 0.8 to 2g, more preferably 0.9 to 1.8g, still more preferably 1.0 to 1.3 g;

nicotinamide: 0.1 to 0.25g, more preferably 0.13 to 0.23g, still more preferably 0.18 to 0.2 g;

folic acid: 0.001-0.003g, more preferably 0.0013-0.0023g, still more preferably 0.0017-0.002 g;

dl- α -tocopheryl acetate: 0.23 to 0.55g, more preferably 0.3 to 0.5g, still more preferably 0.35 to 0.45 g;

d-calcium pantothenate: 0.05 to 0.12g, more preferably 0.07 to 0.1g, still more preferably 0.07 to 0.08 g;

riboflavin: 0.09 to 0.22g, more preferably 0.1 to 0.17g, still more preferably 0.1 to 0.14 g;

pyridoxine hydrochloride: 0.15-0.34g, more preferably 0.2-0.25 g;

thiamine hydrochloride: 0.01-0.028g, more preferably 0.012-0.02 g;

retinyl acetate: 0.03 to 0.07g, more preferably 0.03 to 0.06g, still more preferably 0.04 to 0.05 g;

cholecalciferol: 0.015 to 0.034g, more preferably 0.02 to 0.03 g;

plant menadione: 0.0004 to 0.0009g, more preferably 0.0004 to 0.0007g, still more preferably 0.0005 to 0.0006 g;

cyanocobalamin: 0.00004 to 0.00009g, more preferably 0.00004 to 0.00007g, still more preferably 0.00005 to 0.00006 g;

d-biotin: 0.00007-0.00018g, more preferably 0.00008-0.00016g, still more preferably 0.0001-0.00012 g.

(V) minerals

In a preferred embodiment, the minerals in the low-slag total nutritional formula of the present invention comprise at least 2 of the following ingredients: ferrous sulfate, zinc sulfate, magnesium sulfate, manganese sulfate, potassium iodate, copper sulfate, sodium selenite, potassium citrate, sodium citrate, potassium chloride, calcium hydrophosphate, sodium chloride and calcium carbonate.

The mineral substance zinc is specially supplemented in the mineral substance of the low-residue full-nutrition formula product, the zinc is a component of various enzymes, the zinc loss amount is serious after the operation, and the zinc is required to be supplemented in time after the intestinal tract operation, so that the metabolic immunity is promoted, and the skin wound healing can be accelerated. In addition, the low-slag total nutrient formula product also contains calcium, iron and magnesium which are important mineral elements necessary for human body after operation.

Preferably, in every 1000g of the low-slag total nutrient formula product, the contents of the minerals are respectively as follows:

ferrous sulfate: 0.08 to 0.25g, more preferably 0.1 to 0.22g, further preferably 0.13 to 0.2 g;

zinc sulfate: 0.08 to 0.22g, more preferably 0.1 to 0.2g, further preferably 0.15 to 0.18 g;

magnesium sulfate: 7 to 17g, more preferably 11 to 15g, still more preferably 13 to 14 g;

manganese sulfate: 0.01 to 0.04g, more preferably 0.01 to 0.03g, further preferably 0.01 to 0.02 g;

potassium iodate: 0.0009 to 0.0023g, more preferably 0.001 to 0.0022g, further preferably 0.001 to 0.002 g;

copper sulfate: 0.003-0.009g, more preferably 0.004-0.007 g;

sodium selenite: 0.0003 to 0.0007g, more preferably 0.0003 to 0.0006 g;

potassium citrate: 15 to 32g, more preferably 18 to 27g, further preferably 20 to 27 g;

sodium citrate: 5 to 7.8g, more preferably 5.5 to 7.5g, further preferably 6 to 7.2 g;

potassium chloride: 9-14g, more preferably 10-12 g;

calcium hydrogen phosphate: 2.8 to 5g, more preferably 3.2 to 4.5g, further preferably 3.5 to 4.2 g;

sodium chloride: 2.4 to 5g, more preferably 2.6 to 4.5g, further preferably 2.8 to 4.2 g;

calcium carbonate: 1 to 3g, more preferably 1.3 to 2.8g, still more preferably 1.5 to 2.4 g.

More preferably, the minerals are embedded and mixed with an embedding medium.

(VI) other Components

Food additives, such as sodium carboxymethylcellulose, may also optionally be added to the low-residue total nutrient formulation of the present invention.

When sodium carboxymethylcellulose is added, the low-residue total nutrient formulation of the present invention preferably contains 1 to 18g, more preferably 3 to 15g, and still more preferably 4 to 14g, per 1000g of the formulation.

In order to achieve good intestinal cleanliness, the invention does not add dietary fiber additionally, and strictly controls the content of the dietary fiber brought by the raw materials. The dietary fiber introduced by the raw material is derived from soybean protein isolate, rice protein, maltodextrin and fructose. The invention controls the content of dietary fiber in each 100g of the product to be within 1.58 g. According to the requirements of the food label legislation (see table 1), the range purporting to contain dietary fiber is greater than or equal to 3g/100g, the range claiming to be 0% free of dietary fiber, and the product of the invention controls the dietary fiber to be well below the percentage limit purporting to contain dietary fiber for improved intestinal cleanliness.

Table 1: food labeling legislation

In the intestinal examination, besides the cleanliness of the intestinal tract, the quality of the enteroscopy is greatly affected by the increase of bubbles caused by flatulence. In order to avoid intestinal flatulence and reduce bubble formation, it is clinically necessary to add an antifoaming agent (e.g., simethicone) to reduce bubble formation. The food-derived gas production is an important reason for causing flatulence, so that various food-derived gas production factors are fully considered and inhibited to reduce the food-derived gas production.

One measure of inhibiting the gas production is to strictly control the content of the dietary fiber to be below 1.58 percent, because the cellulose is one of the causes of the gas production, and the aims of extremely low slag and inhibiting the gas production are achieved by inhibiting the content of the dietary fiber.

Further, in a particularly preferred embodiment, the low-slag total nutrient formulation of the present invention comprises the following ingredients: soy protein isolate, rice protein, maltodextrin, fructose, low protein fat powder, sodium L-ascorbate, niacinamide, folic acid, dl-alpha-tocopherol acetate, D-calcium pantothenate, riboflavin, pyridoxine hydrochloride, thiamine hydrochloride, retinyl acetate, cholecalciferol, phytomenadione, cyanocobalamin, D-biotin, ferrous sulfate, zinc sulfate, magnesium sulfate, calcium carbonate, and optionally added food additives, such as sodium carboxymethylcellulose.

In a more specific preferred embodiment, the low-slag total nutritional formula of the present invention comprises per 1000 g: 150-250g of isolated soybean protein, 20-40g of rice protein, 70-130g of maltodextrin, 150-300g of fructose, 400g of fat 230, 0.8-2g of sodium L-ascorbate, 0.1-0.25g of nicotinamide, 0.001-0.003g of folic acid, 0.23-0.55g of dl-alpha-tocopherol acetate, 0.05-0.12g of D-calcium pantothenate, 0.09-0.22g of riboflavin, 0.15-0.34g of pyridoxine hydrochloride, 0.01-0.028g of thiamine hydrochloride, 0.03-0.07g of retinyl acetate, 0.015-0.034g of cholecalciferol, 0.0004-0.0009g of plant menadione, 0.00004-0.00009g of cyanocobalamine, 0.00007-0.18 g of D-biotin, 0.08-0.25g of ferrous sulfate, 0.08-0.08 g of zinc sulfate, 0.01-0.0009 g of potassium iodate, 0.0027-0.17 g of potassium sulfate, 0.7-0.0029 g of potassium iodate, 0.7-0.18 g of potassium sulfate, 0.15g of sodium sulfate, 0.003-0.009g of copper sulfate, 0.0003-0.0007g of sodium selenite, 15-32g of potassium citrate, 5-7.8g of sodium citrate, 9-14g of potassium chloride, 2.8-5g of calcium hydrophosphate, 2.4-5g of sodium chloride, 1-3g of calcium carbonate and 1-18g of sodium carboxymethylcellulose optionally added.

More preferably, the low-slag total nutrient formula of the present invention comprises per 1000 g: 210g of soybean protein isolate 170-, 0.004-0.007g of copper sulfate, 0.0003-0.0006g of sodium selenite, 18-27g of potassium citrate, 5.5-7.5g of sodium citrate, 10-12g of potassium chloride, 3.2-4.5g of calcium hydrophosphate, 2.6-4.5g of sodium chloride, 1.3-2.8g of calcium carbonate and 3-15g of sodium carboxymethylcellulose which is an optional food additive.

More preferably, the low-slag total nutrient formula of the present invention comprises per 1000 g: 200-210g of soybean protein isolate, 28-33g of rice protein, 100-118g of maltodextrin, 240g of fructose 230, 345g of fat 330, 1.0-1.3g of L-sodium ascorbate, 0.18-0.2g of nicotinamide, 0.0017-0.002g of folic acid, 0.35-0.45g of dl-alpha-tocopherol acetate, 0.07-0.08g of D-calcium pantothenate, 0.1-0.14g of riboflavin, 0.2-0.25g of pyridoxine hydrochloride, 0.012-0.02g of thiamine hydrochloride, 0.04-0.05g of retinyl acetate, 0.02-0.03g of cholecalciferol, 0.0005-0.0006g of phytonadione, 0.00005-0.00006g of cyanocobalamine, 0.0001-0.12 g of D-biotin, 0.13-0.2.002 g of ferrous sulfate, 0.002-0.01-0.15 g of zinc sulfate, 0.01-0.14 g of potassium sulfate, 0.02-0.02 g of potassium iodate, 0.15.15 g of potassium sulfate, 0.15.01-0.15 g of potassium sulfate, 0.004-0.007g of copper sulfate, 0.0003-0.0006g of sodium selenite, 20-27g of potassium citrate, 6-7.2g of sodium citrate, 10-12g of potassium chloride, 3.5-4.2g of calcium hydrophosphate, 2.8-4.2g of sodium chloride, 1.5-2.4g of calcium carbonate and 4-14g of sodium carboxymethyl cellulose which is optionally added as a food additive.

In a second aspect, the present invention provides a method of preparing a low-slag total nutrient formulation. The method comprises the following steps: (1) pretreatment, (2) weighing, (3) crushing and screening, (4) primary mixing, and (5) total mixing.

As one of the preferable schemes, the pretreatment step of step (1) is to sterilize each raw material and the optional food additive by irradiating them with ultraviolet light for 2 hours.

As a second preferred embodiment, the pulverizing and sieving in step (3) is to pass each raw material and optionally used food additive through a sieve of 100 meshes or more.

As a third preferred scheme, the initial mixing conditions in the step (4) are as follows: and preliminarily mixing various vitamins, various mineral substances, rice protein and optionally used food additives according to the weighed amount in an environment with the temperature not higher than 28 ℃ and the humidity not higher than 65% for 10-20 min until the mixture is uniform.

As a fourth preferred embodiment, the total mixing conditions in the step (5) are as follows: and (3) adding the maltodextrin, the soybean protein isolate, the fructose and the fat into the primary mixed material obtained in the step (4) according to the weighed amount, and mixing for 20-40 min, preferably 30min, in an environment with the temperature not higher than 28 ℃ and the humidity not higher than 65% until the mixture is uniform.

In a third aspect, the present invention provides the use of the low-residue total nutrient formulation described above.

One is the use of the preparation in preparation for bowel cleansing.

And the second is the use of the preparation in the preparation of a bowel cleansing preparation.

As a preferred technical solution, the preparation for intestinal tract cleaning is preparation for intestinal tract cleaning before colonoscopy, duodenoscope, sonoendoscopy, and capsule endoscopy.

More preferably, the bowel cleansing preparation is a bowel cleansing preparation prior to colonoscopy.

And thirdly, the use of the product in the preparation of intestinal tract cleansing prior to surgery requiring intestinal tract preparation. The surgical operations comprise colorectal cancer operations, colorectal cancer radical operations, total colectomy, gastrointestinal tract operations under laparoscope, pancreaticoduodenectomy, small intestine wide excision, small intestine partial excision and intestinal stoma (fistula) closure.

And fourthly, the use of the product in nutritional support following bowel surgery, including colorectal cancer surgery, radical colorectal cancer surgery, total colectomy, laparoscopic gastrointestinal surgery, pancreaticoduodenal resection, wide small intestine resection, intestinal stoma (fistula) closure.

The preparation for cleaning the intestinal tract is to eat the low-slag total nutrient formula product as three meals, namely morning, noon and evening, wherein the dosage of each meal is 180 g.

The low-slag total-nutrient formula product has the following beneficial effects:

the use of the low-slag total nutrient formulation of the present invention for bowel cleansing preparation is more effective than prior art enteral formulas and traditional enteral preparation by liquid diet. The method comprises the following steps:

1. the food residues in the intestinal tract are greatly reduced while no dietary fiber is added and the cellulose content is very low, so that the food residues are easily and completely absorbed by the small intestine, the intestinal tract cleanliness is improved, the microscopic examination rate and the microscopic examination quantity are improved, the microscopic examination time and difficulty are reduced, and the repeated microscopic examination is avoided; while reducing the incidence of infection in patients with intestinal surgery.

2. Does not contain food-borne gas-producing components, avoids intestinal gas-producing flatulence, reduces the generation rate of intestinal bubbles, and improves microscopic examination quality and success rate.

3. The nutrition proportion is scientific and comprehensive, sufficient nutrition is supplemented for patients with microscopic examination and intestinal surgery, and adverse reactions such as dizziness, palpitation, syncope and the like in the enema process are effectively reduced; the immunity of the operation patient is improved, and the problems of slow postoperative recovery, susceptibility to infection and the like caused by low immunity are effectively solved.

4. The pure natural, high-quality and easily-absorbed soybean protein isolate and rice protein powder are selected as protein sources to replace casein which is difficult to absorb, and the matching of the two vegetable proteins is beneficial to the absorption of nutrition of patients.

5. The low-slag total nutrient formula product does not contain lactose, avoids diarrhea caused by lactose intolerance of partial patients, and is easy to be accepted by the patients.

Examples

The present invention is further described in detail below with reference to specific examples, which are given for illustrative purposes only and are not intended to limit the scope of the present invention. Any modification or substitution of the present invention is within the scope of the present invention without departing from the spirit and substance of the present invention.

Example 1: low-slag full-nutrition formula product1

This example contains, as vitamins, per 1000g of the product: 1.8g of L-ascorbic acid sodium, 0.23g of nicotinamide, 0.0023g of folic acid, 0.5g of dl-alpha-tocopherol acetate, 0.1g of D-calcium pantothenate, 0.17g of riboflavin, 0.32g of pyridoxine hydrochloride, 0.02g of thiamine hydrochloride, 0.06g of retinyl acetate, 0.03g of cholecalciferol, 0.0007g of phytomenadione, 0.00007g of cyanocobalamin and 0.00016g of D-biotin.

This example contains, as minerals, per 1000g of the product: 0.2g of ferrous sulfate, 0.2g of zinc sulfate, 15g of magnesium sulfate, 0.02g of manganese sulfate, 0.002g of potassium iodate, 0.007g of copper sulfate, 0.0006g of sodium selenite, 27g of potassium citrate, 7.2g of sodium citrate, 12g of potassium chloride, 4g of calcium hydrophosphate, 3.4g of sodium chloride and 2g of calcium carbonate, and the minerals are uniformly mixed by using 20g of maltodextrin as an embedding agent.

The dosage of raw materials per 1000g of the product is as follows: soy protein isolate 210g, rice protein 30g, maltodextrin 100g (including maltodextrin as embedding agent), low protein fat powder 320g (available from motai technologies (Qingdao) corporation), sodium carboxymethylcellulose 16g, vitamins and minerals in amounts as described above, with the balance being fructose.

Preparation: (1) pretreatment: irradiating the raw materials and food additives with ultraviolet lamp for 2 hr for sterilization; (2) weighing: weighing the raw materials and the food additive according to the dosage; (3) crushing and sieving: sieving the food additive with 100 mesh sieve; (4) primary mixing: preliminarily mixing various vitamins, various mineral substances, rice protein and sodium carboxymethylcellulose according to the weighed amount in an environment with the temperature of 22 ℃ (the humidity is controlled to be not more than 65%) for 20min until the mixture is uniform; (5) total mixing: respectively adding maltodextrin, soy protein isolate, fructose and fat into the primary mixed material obtained in the step (4) according to the weighed amount, and mixing for 30min in an environment of 22 ℃ (the humidity is controlled to be not more than 65%) until the mixture is uniform; (6) quantitative filling and packaging: and (4) filling and packaging the total mixture obtained in the step (5) according to the required amount to prepare the low-slag total-nutrient formula product 1.

Example 2: low-slag total nutrient formula product 2

This example contains, as vitamins, per 1000g of the product: 1.2g of L-ascorbic acid sodium, 0.18g of nicotinamide, 0.0017g of folic acid, 0.4g of dl-alpha-tocopherol acetate, 0.07g of D-calcium pantothenate, 0.1g of riboflavin, 0.2g of pyridoxine hydrochloride, 0.012g of thiamine hydrochloride, 0.04g of retinyl acetate, 0.03g of cholecalciferol, 0.0005g of phytomenadione, 0.00006g of cyanocobalamin and 0.00012g of D-biotin.

This example contains, as minerals, per 1000g of the product: 0.15g of ferrous sulfate, 0.15g of zinc sulfate, 13g of magnesium sulfate, 0.015g of manganese sulfate, 0.001g of potassium iodate, 0.005g of copper sulfate, 0.0004g of sodium selenite, 25g of potassium citrate, 6.5g of sodium citrate, 11g of potassium chloride, 3.6g of calcium hydrophosphate, 2.8g of sodium chloride and 1.8g of calcium carbonate, and the minerals are uniformly mixed by using 20g of maltodextrin as an embedding agent.

Raw material dosage: 205g of isolated soy protein, 30g of rice protein, 238g of fructose, 343g of fat, 14g of sodium carboxymethylcellulose, vitamins and minerals in the amounts described above, and the balance maltodextrin. The fat is prepared from vegetable fat and medium chain triglyceride according to the mass ratio of 5: 3, and the vegetable oil and fat consists of corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil according to the mass ratio of 31:21.5:20:19: 8.5.

The preparation method is the same as that of example 1, and the low-slag total nutrient formula product 2 is prepared.

Example 3: low-slag total nutrient formula product 3

This example contains, as vitamins, per 1000g of the product: 1g of L-sodium ascorbate, 0.1g of nicotinamide, 0.001g of folic acid, 0.25g of dl-alpha-tocopherol acetate, 0.06g of D-calcium pantothenate, 0.1g of riboflavin, 0.2g of pyridoxine hydrochloride, 0.012g of thiamine hydrochloride, 0.04g of retinyl acetate, 0.02g of cholecalciferol, 0.0005g of phytomenadione, 0.00006g of cyanocobalamin and 0.0001g of D-biotin.

This example contains, as minerals, per 1000g of the product: 0.1g of ferrous sulfate, 0.2g of zinc sulfate, 10g of magnesium sulfate, 0.015g of manganese sulfate, 0.002g of potassium iodate, 0.004g of copper sulfate, 0.0005g of sodium selenite, 18g of potassium citrate, 5g of sodium citrate, 9g of potassium chloride, 2.8g of calcium hydrophosphate, 2.4g of sodium chloride and 1g of calcium carbonate, and the minerals are uniformly mixed by using 20g of maltodextrin as an embedding agent.

The dosage of raw materials per 1000g of the product is as follows: the amounts of soy protein isolate 240g, rice protein 37g, maltodextrin 120g (including maltodextrin as embedding agent), fructose 280g, sodium carboxymethylcellulose 18g, vitamins and minerals were as described above, with the balance being low protein fat powder (available from motto technologies, Qingdao, Inc.).

The preparation method is the same as example 1, and the low-slag total nutrient formula product 3 is prepared.

Example 4: low-slag total nutrient formula product 4

This example contains, as vitamins, per 1000g of the product: 2g of L-ascorbic acid sodium, 0.1g of nicotinamide, 0.001g of folic acid, 0.25g of dl-alpha-tocopherol acetate, 0.06g of D-calcium pantothenate, 0.22g of riboflavin, 0.31g of pyridoxine hydrochloride, 0.024g of thiamine hydrochloride, 0.07g of retinyl acetate, 0.03g of cholecalciferol, 0.0008g of plant menadione, 0.00009g of cyanocobalamin and 0.00016g of D-biotin.

This example contains, as minerals, per 1000g of the product: 0.25g of ferrous sulfate, 0.22g of zinc sulfate, 17g of magnesium sulfate, 0.04g of manganese sulfate, 0.0022g of potassium iodate, 0.008g of copper sulfate, 0.0007g of sodium selenite, 32g of potassium citrate, 7.8g of sodium citrate, 14g of potassium chloride, 5g of calcium hydrophosphate, 3.8g of sodium chloride and 2.7g of calcium carbonate, and the minerals are uniformly mixed by using 20g of maltodextrin as an embedding agent.

The dosage of raw materials per 1000g of the product is as follows: 37g of rice protein, 100g of maltodextrin (including maltodextrin serving as an embedding agent), 200g of fructose, 390g of fat, 18g of sodium carboxymethyl cellulose, vitamins and minerals, and the balance of isolated soy protein, wherein the fat is composed of vegetable oil and medium-chain triglyceride in a mass ratio of 4: 3, and the vegetable oil and fat consists of corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil according to the mass ratio of 30:21:20:21: 8.

The preparation method is the same as that of example 1, and the low-slag total nutrient formula 4 is prepared.

Example 5: low-residue full-nutrition formula product 5

This example contains, as vitamins, per 1000g of the product: 1g of L-sodium ascorbate, 0.2g of nicotinamide, 0.003g of folic acid, 0.55g of dl-alpha-tocopherol acetate, 0.12g of D-calcium pantothenate, 0.22g of riboflavin, 0.15g of pyridoxine hydrochloride, 0.015g of thiamine hydrochloride, 0.04g of retinyl acetate, 0.02g of cholecalciferol, 0.0006g of phytomenadione, 0.00007g of cyanocobalamin and 0.0001g of D-biotin.

This example contains, as minerals, per 1000g of the product: 0.10g of ferrous sulfate, 0.09g of zinc sulfate, 10g of magnesium sulfate, 0.04g of manganese sulfate, 0.001g of potassium iodate, 0.005g of copper sulfate, 0.0007g of sodium selenite, 18g of potassium citrate, 5g of sodium citrate, 10g of potassium chloride, 3g of calcium hydrophosphate, 3.8g of sodium chloride and 2g of calcium carbonate, and the minerals are uniformly mixed by using 20g of maltodextrin as an embedding agent.

The dosage of raw materials per 1000g of the product is as follows: the weight of the soybean protein isolate 190g, the rice protein 37g, the fructose 200g, the fat 390g, the sodium carboxymethyl cellulose 18g, the vitamins and the minerals are as described above, and the balance is maltodextrin, wherein the fat is prepared from vegetable fat and medium chain triglyceride in a mass ratio of 5: 3, and the vegetable oil and fat consists of corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil according to the mass ratio of 31:21:20:19: 9.

The preparation method is the same as example 1, and the low-slag total nutrient formula product 5 is prepared.

Example 6: sensory evaluation test

(1) Sensory evaluation volunteers: 30 enteroscope testees and 30 patients after intestinal tract operation. For the enteroscope testers, the formula product is taken for three meals 1 day before the enteroscope, 1-2 bags of the formula product are taken each time, and the formula product is taken with 200ml of warm boiled water. For intestinal tract postoperative patients, the composition is taken after three meals 3 days after operation, 1-2 bags each time, and is taken with 200ml of warm boiled water.

(2) The sensory experience evaluation results of the enteroscope subjects are shown in table 2.

Table 2: microscopic examination sensory evaluation

Taste of the product	Number of people	Smell(s)	Number of people	Adverse events	Number of people
						Has good taste	21	Has good smell	25	Abdominal distention	0
Has good taste	7	Has good smell	3	Nausea and vomiting	1
						The taste is general	2	Can tolerate	2	Dizziness and palpitation	1
Has poor taste	0	Cannot tolerate	0

(3) Sensory and nutritional support tests for postoperative patients are shown in table 3.

Table 3: postoperative nutrition support test

Taste of the product	Number of people	Smell(s)	Number of people	Adverse events	Number of people
						Has good taste	19	Has good smell	18	Bleeding	0
Has good taste	1	Has good smell	2	Perforation	0
						The taste is general	0	Can tolerate	0	Infection with viral infection	0
Has poor taste	0	Cannot tolerate	0

The results show that the product of the invention has good taste, proper dosage, normal sleep and no adverse reaction.

Example 7: evaluation of intestine clearing effect of low-residue total-nutrient formula product

The role of the low-slag total nutritional formula of the present invention in colonoscopy bowel preparation was evaluated by comparing the differences between colonoscopy patients using low-slag total nutritional formula to assist bowel preparation and traditional bowel preparation methods.

(1) Study object

A patient to be subjected to a colonoscopy. The selected age is 18-65 years, the body weight is less than 60kg, and the enteroscopy is performed in the morning on the next day. The following patients were excluded: patients with severe mental illness who are difficult to coordinate and have poor communication ability; patients with hyperglycemia, severe constipation, and digestive tract hemorrhage; patients with a history of colon surgery, colonic obstruction, pregnant women, lactating and women who plan for pregnancy; other intolerant enteroscopies, such as heart failure, stroke, chronic mosaic pulmonary disease, renal failure, etc., are known or suspected.

(2) Test method

A prospective random comparison test design is adopted, a computer software is adopted for simulation to generate random numbers, 60 screened qualified subjects are randomly divided into a test group and a comparison group according to the proportion of 1:1, and each group comprises 30 subjects.

The control group of patients had intestinal preparation before conventional colonoscopy, and the specific steps were: the soft noodles or rice gruel can be eaten as three meals 1 day before colonoscopy and before laxative is taken, and water can be freely drunk without eating other foods.

The preparation of the intestine for the patients in the test group was carried out by: the low-residue total nutrient formula product of the embodiment 2 is taken as three meals, 120 plus 180g of each meal, from 1 day before colonoscopy to before laxatives are taken, and the low-residue total nutrient formula product is uniformly stirred in warm water of about 200ml and then taken, so that other foods are not taken any more, and water can be freely drunk.

The patients in the control group and the test group start to take the cathartic at 20:00 o ' clock before and after the examination, take the cathartic again at 5:00 o ' clock in the morning of the examination, and are forbidden to take water at 6:30 o ' clock.

(3) Observation index

Index 1: the cleanliness of intestinal tract.

The cleanliness scoring standard adopts a Boston scale scoring method. The Boston scale divides the colon into 3 segments of right, transverse, and left colon, and scores after aspiration and perfusion. Each segment of colon is scored for 0-3 points, and the total score is 0-9 points; the score of each segment of colon is more than or equal to 2 points, so that the preparation of the intestinal tract is full; the total score is less than 6 or the score of any segment of colon is less than 2, the preparation of intestinal tract is not sufficient, and the specific scoring standard is as follows:

boston scale scoring method

Score of	Segmentation score of right colon, transverse colon, left colon
		0 point (min)	Has a large amount of solid residues and invisible mucous membrane
1 minute (1)	With solid or liquid residues and mucosal part visible
		2 is divided into	Brown liquid, mobile semisolid residue, mucosa all visible
3 points of	Clean, the mucous membrane is totally visible

Index 2: detection rate and detection number of adenomas and polyps.

Index 3: feeling of flatulence.

(4) Test results

From the above results, it can be seen that:

in the test group, the intestinal cleanliness is 20 cases which account for 66.7 percent; in the control group, 17 cases of qualified intestinal cleanliness account for 56.7%. Therefore, the intestinal cleanliness of patients using the low-slag total nutrient formula product is obviously better than that of the control group.

In the test group, the number of polyp detection cases was 22, accounting for 73.3%; the number of cases of adenomas detected was 16, which accounted for 53.3%. In the control group, the number of polyp detection cases was 16, which accounted for 53.3%; the number of cases of adenomas detected was 10, which accounted for 33.3%. Thus, patients using the low-slag total nutrient formula of the invention had higher detection rates of polyps and adenomas than the control group when subjected to enteroscopy.

In the test group, no flatulence occurred, while in the control group, 5 cases had flatulence occurred. Therefore, the incidence of flatulence in the test group was significantly lower than that in the control group.

From the test results, compared with the conventional colonoscope intestinal tract preparation method, the low-slag total-nutrient formula product can obviously improve the cleanliness of the intestinal tract and reduce intra-abdominal flatulence, thereby improving the detection rate of adenoma and polyp, promoting postoperative recovery, reducing the inspection cost and improving the safety of microscopic examination.

Claims

1. A low-slag total nutrient formula product for preparing intestinal tract cleaning is characterized in that each 1000g of the low-slag total nutrient formula product contains 240g of soybean protein isolate 190-, 0.1-0.25g of ferrous sulfate, 0.09-0.22g of zinc sulfate, 10-17g of magnesium sulfate, 0.015-0.04g of manganese sulfate, 0.001-0.0022g of potassium iodate, 0.004-0.008g of copper sulfate, 0.0004-0.0007g of sodium selenite, 18-32g of potassium citrate, 5-7.8g of sodium citrate, 9-14g of potassium chloride, 2.8-5g of calcium hydrophosphate, 2.4-3.8g of sodium chloride, 1-2.7g of calcium carbonate and 14-18g of sodium carboxymethylcellulose which is an optionally added food additive; the fat is mixed at a ratio of 4-5: 3, the vegetable oil comprises corn oil, sunflower seed oil, soybean oil, rapeseed oil and coconut oil according to the mass ratio of 30-31:21-21.5:20:19-21:8-9, and the content of dietary fiber in each 100g of the low-residue full-nutrition formula product is less than 1.58 g; the preparation method of the low-slag total-nutrient formula product comprises the following steps of: (1) pretreatment, (2) weighing, (3) crushing and screening, (4) primary mixing, and (5) total mixing.

2. The method of making a low slag total nutrient formulation of claim 1, comprising the steps of: (1) pretreatment, (2) weighing, (3) crushing and screening, (4) primary mixing, and (5) total mixing.

3. Use of a low-profile total nutrient formulation according to claim 1 in the preparation of a bowel cleansing preparation.

4. Use according to claim 3, the preparation for bowel cleansing being a preparation for bowel cleansing prior to bowel surgery or before enteroscopy.

5. Use of the low-slag total nutrient formulation of claim 1 in nutritional support following intestinal surgery.