CN108771647A - Treat the camellia soothing oil and preparation method thereof of scald - Google Patents
Treat the camellia soothing oil and preparation method thereof of scald Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
Abstract
The camellia soothing oil for treating scald, is uniformly mixed according to mass fraction by following component：80~85 parts of cold press camellia oil, 15~20 parts of Chinese herbal medicine, 0.3-0.5 parts of antioxidant content.Wherein Chinese herbal medicine is uniformly mixed according to mass fraction by 5~10 parts of Flos Hibisci Mutabilis, 3~5 parts of raw rhubarb, 3~5 parts of Radix Sangusorbae；Wherein antioxidant content is 0.2-0.3 parts of vitamin E, 0.1-0.2 parts of tea polyphenol-palmitate mixes.Its technique is to place 2 years or more in the medicinal herb soak to tea oil after drying, and camellia soothing oil is obtained by filtration.The camellia soothing oil can effectively treat I degree and light degree Ⅱ scald symptom, also have extraordinary effect to the postoperative reparation of deep II degree of scald.
Description
Technical field
The present invention relates to a kind of camellia soothing oil, especially a kind of camellia soothing oil for treating scald.
Background technology
Camellia oil also known as Wild camellia seed oil, tea-seed oil, camellia seed oil, squeeze the seed from tea oil tree.The tradition system of camellia oil
Include decladding, dry, crush, extract oil as process, filters, overall process is physical method, is fully natural green edible oil.The biography
Erucic acid, cholesterol, aflatoxins and other additives are free of in the tea oil that system technique presses, and are beneficial to the unsaturated fat of human body
Acid content is up to 90% or more, wherein oleic acid 80-83%, and linoleic acid 7-13%, especially contained linoleic acid, leukotrienes are human bodies
It must and cannot synthesize, rich in vitamin E etc..Camellia oil contains unsaturated fatty acid more higher than olive oil and natural dimension
Raw element E, also contain the natural nourishing skin care ingredient such as tea polyphenols, squalene, tsubakisaponin and a variety of anti-oxidant, antibacterial anti-inflammatory at
Point, it is beauty treatment moisturizing sage's product, beauty functions particularly successive dynasties women population is praised highly, and has been continued to use thousand.In civil, meeting after scald
It is treated using tea oil, and tea oil has extraordinary effect really in the effect for the treatment of scald.
Invention content
The purpose of the present invention is the deficiency for existing product, provides a kind of pure natural camellia profit for treating scald effect
Skin oil and preparation method thereof.
The technical scheme is that：
The camellia soothing oil for treating scald, is uniformly mixed according to mass fraction by following component:Cold press camellia oil 80~85
Part, 15~20 parts of Chinese herbal medicine, 0.3-0.5 parts of antioxidant content.
The Chinese herbal medicine is uniform by 5~10 parts of Flos Hibisci Mutabilis, 3~5 parts of raw rhubarb, 3~5 parts of Radix Sangusorbae according to mass fraction
It mixes.
The antioxidant content is according to mass fraction by 0.2-0.3 parts of vitamin E, tea polyphenol-palmitate 0.1-0.2
Part mixes.
The camellia soothing oil of the treatment scald, it is characterised in that：Its preparation process carries out as follows：
1）Freeze-drying mode is taken to be dried fresh herbal raw material（Precooling：10-20 DEG C, 4-5 hours；Drying condition：
20-25 DEG C of baffle temperature, 10-15 hours）；
2）The shape that fragmentates is pulverized after drying；
3）15-20 parts of herbal raw materials are weighed, are immersed in 80-85 parts of cold press camellia oils, antioxidant content 0.3-0.5 is added
Part；
4）By nitrogen charging in container, by bottle sealing, it is positioned at shady and cool drying and stands dissolution；
5）After 2-3 to be placed, medicinal herb soak oil is filtered, the camellia soothing oil for the scald that obtains medical treatment.
Camellia oil of the present invention is cold press camellia oil.
Preferably, the camellia oil refines in Wild Woody oil section fruit, is four big xylophyta oil of the world
One.Tea oil contains specific physiological activator tea polyphenols and camellianin（That is tea saponin or Tea Saponin）, given birth to rich in higher dimension
Plain E, containing squalene and Flavonoid substances, to anticancer, it is anti-inflammatory play the role of it is splendid.
Preferably, the technological process whole process low temperature of the cold press camellia oil retains the wind of tea oil most original to the greatest extent
Taste and nutrient is not destroyed, the active ingredient of tea oil anti-inflammation and sterilization is mainly camellianin, and camellianin is soluble easily in water, by refining
After can substantially reduce its content, low temperature also can make squalene, flavones etc. not be destroyed.
Preferably, the camellianin also known as tea saponin or Tea Saponin, have good anti-inflammatory, analgesic activity, to bacterium,
Mould etc. all has good inhibiting effect, Jiang Yanling etc.（Jiang Yanling etc., 2008）Inquired into suppression of the tea oil to common microbiological
Effect processed, studies have shown that the camellianin in tea oil all has well staphylococcus aureus, aspergillus niger, Escherichia coli etc.
Fungistatic effect, and its bacteriostasis is not influenced by pH value, thermal stability is high.
Preferably, the principle that the technological process uses is the similar principle that mixes, and what is extracted is the volatilization in Chinese herbal medicine
Property derived essential oil, the method is simple for process, low energy consumption, yield is high, and filter residue can pass through oil immersion repeatedly therein to be had fully to extract
Imitate ingredient.
The Flos Hibisci Mutabilis floral leaf is used as medicine, and has clearing heat and cooling blood, detumescence and apocenosis and other effects, is suitable for furuncle, sore carbuncle, acute mastitis and lung
The illnesss such as heat cough, lung carbuncle；Uterine bleeding caused by what blood-head can be used again, often used with contract with lotus receptacle.The function of cottonrose hibiscus leaf and flower
It is similar, generally often make external application, energy detumescence ding-tong, suitable for drawing after furuncle, furunculosis, carbuncle swells, scald and buttock injections injection
The lump risen, which does not disappear, waits diseases.
The rheum officinale primary efficacy is heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.For real heat constipation, product
Stagnant abdominal pain, rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle swells furunculosis, blood stasis closed, bruise damage
Wound, controls scald outside.Rheum palmatum (processed with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system, is used for hot eyes pharynx swelling, gingivitis.Prepared RADIX ET RHIZOMA RHEI, which rushes down, to be exerted oneself to delay,
Purging intense heat and detonicating is used for pathogenic fire,toxin and furuncles.Charred RADIX ET RHIZOMA RHEI cooling blood and removing stasis stops blooding, and has stasis of blood bleeder for blood-head.
There is the Radix Sangusorbae astriction, garden burnet to contain tannin, have astriction, can antidiarrheal and hemostasis.External application
Radix Sanguisorbae preparata powder has notable astriction to II degree of rabbit and dog, III degree of experimental scald face, exudation can be made to reduce, infection and
The death rate reduces.There is Radix Sangusorbae antibacterial action, experiment in vitro to prove：The decocting liquid of garden burnet 100% to typhoid bacillus, meningitis,
Diplococcus, shigella flexneri, in Song, shigella dysenteriae, beta hemolytic streptococcus, staphylococcus aureus, the double balls of pneumonia
Bacterium, corynebacterium diphtheriae, Escherichia coli, hay bacillus, typhoid bacillus, paratyphosum Bacterium, Pseudomonas aeruginosa, cholera, vibrios and human-like, knot
Core bacillus has different degrees of inhibiting effect.Also there is different degrees of inhibiting effect to certain fungies, decoction is in 0.5mg/mL
When it is effective to Asia influenza A virus.Radix Sangusorbae also has anti-inflammatory effect, garden burnet PARA FORMALDEHYDE PRILLS(91,95) pedal swelling mouse, croton oil
Property auricular concha swelling has apparent inhibiting effect；To Dermal microvessel permeability caused by prostaglandin E, garden burnet has very strong
Inhibiting effect；The hyperplasia of swollen hyperplasia of rat granuloma can still be inhibited, and wound healing can be promoted.
Preferably, three kinds of Chinese herbal medicines that the present invention uses all have the effect of extraordinary treatment scald, make the present invention more
It is suitable for treatment scald.
Preferably, processing is dried using freeze-drying mode in the Chinese herbal medicine of use of the invention so that plant cell
Between form open structure, active principle, which is easier to dissolve out, to be come.
Preferably, two kinds of antioxidant contents that the present invention uses is extracted form natural plants, antioxidant effect highly significant, energy
Protect grease not oxidized.
Preferably, during the present invention stands dissolving-out process, using nitrogen filled protection, keep raw material not oxidizable, slow down activity
The decay of ingredient.
The present invention treats the use of the camellia soothing oil of scald, usually uses semar technique, for example take appropriate painting with disinfecting cotton swab
It smears in skin or affected part, then presses lightly on, appropriateness rubbing is in favor of absorption.
Primary raw material used in the present invention is described as follows：
Camellia oil：Camellia seed kernel is through cleaning, air-drying（Temperature is less than 100 DEG C）, shelling, seed selection sterilization after, carried out at 20-50 DEG C
Squeezing gained, active material is abundant, generally about contains vitamin E 200mg/kg, sterol 30mg/kg, squalene 100mg/
kg。
Flos Hibisci Mutabilis：Lotus category Malvaceae, fall leaves big shrub or small high forest are high up to 7 meters.Stem has stellate hair or pubescence.
Ye great, wealthy oval and be bordering on that round shape is oval, and palmate 5-7 is split, there is a crenation at edge, and there is yellowish-brown villus on two sides, flower-shape it is big and
Beauty, is born in branch, single-lobe or polyphyll, and bennet grows 5 one 8 centimetres, that life is luxuriant 8 pieces small, and calyx is short, bell, and 10 1 November bloomed, clearly
It is creamy white when morning blooms or pink, becomes peony at dusk.Capsule is spherical.Originate in China Yellow River basin and East China, south China
Various regions, flower or white or powder or red, if clear and bright, hibiscus rising out of water, gorgeous to open up valve like lotus, therefore has the title of " Flos Hibisci Mutabilis ", and because it is born in land
Ground is xylophyta, and it is also known as " cotton roses ".The flower that cotton rose opens changes very much in one day, and it is also known as " three become flower ".It spends late fall to begin
Open, frost invades dew, and to insult but fine bearing gorgeous, gains all late autumn landscape, thus also known as " refusing frostwork ".Flos Hibisci Mutabilis likes the weather of warm and moist,
Sunlight is liked, adaptability is stronger.Flower contains glycosides displayed and anthocyanin (anthocyanin)：The former has Isoquercitrin
(isoquercitrin), hyperin (hyperoside), rutin (rutin), the "-glycoside of Quercetin -4
(quercetin-4 "-glucoside), i.e. spiraeoside (spi-raeoside), quercimeritrin (quercimeritrin)；Flower
Color glucoside has Cyanidin 3,5- diglucosides (cyanidin 3,5-diglucoside), Cyanidin -3- rutinosides -5-
Glycoside (cyanidin 3-rutinoside-5-glucoside), Cyanidin -3- synthetisms.Flos Hibisci Mutabilis have clearing heat and cooling blood,
Detumescence and apocenosis and other effects is suitable for the illnesss such as furuncle, sore carbuncle, acute mastitis and cough with lung heat, lung carbuncle；It can be used and collapsed caused by what blood-head again
Leakage is often used with lotus receptacle with contract.Cottonrose hibiscus leaf is similar to the function of flower, generally often makees external application, and energy detumescence ding-tong is suitable for heat
Caused lump such as does not disappear the diseases after furuncle, furunculosis, carbuncle swells, scald and buttock injections injection.
Vitamin E：Vitamin E（Vitamin E）It is a kind of liposoluble vitamin, hydrolysate is tocopherol, is most
One of main antioxidant.It is dissolved in the organic solvents such as fat and ethyl alcohol, it is not soluble in water, heat, acid are stablized, to alkali shakiness
It is fixed, it is sensitive to oxygen, it is insensitive to heat, but Vitamin E activity is substantially reduced when frying.Tocopherol can be used for prevent burn, frostbite,
Capillary hemorrhage, climacteric syndrome, beauty etc..Recently it has also been found that vitamin E can inhibit the mistake in ocular lens body
Fat reaction is aoxidized, peripheral vasodilation is made, improves blood circulation, pre- Anti-myopic eye occurrence and development.Phenol on vitamin E phenyl ring
Hydroxyl is acetylation, and it is tocopherol that ester hydrolysis, which is after phenolic hydroxyl group,.
Tea polyphenol-palmitate：For food additives new varieties, tea polyphenol-palmitate is extracted by raw material of green tea
Tea polyphenols pass through with palmitoyl chloride be esterified, filtering, washing, precipitation, crystallization, centrifugation, freeze-drying, packaging and other steps process and
At, can be used as antioxidant for it is substantially free of water fat and oil in.
Specific implementation mode
Below by embodiment, the invention will be further described, but not as a limitation of the invention.
Embodiment 1-6
The dispensing situation of the camellia soothing oil of the treatment scald of table 1 embodiment 1-6, comparative example 1-3
。
Above example, the preparation method of comparative example are as follows：
1）It takes freeze-drying mode to be dried fresh herbal raw material, is pre-chilled 20 DEG C, 5 hours；Drying condition：Partition board
25 DEG C, 15 hours of temperature；
2）It pulverizes and fragmentates after drying；
3）Herbal raw material is weighed, is immersed in cold press camellia oil, antioxidant content is added；
4）By nitrogen charging in container, by bottle sealing, it is positioned at shady and cool drying and stands dissolution；
5）After 2 years to be placed, medicinal herb soak oil is filtered, the camellia soothing oil for the scald that obtains medical treatment.
For comparative example 4 in addition to time of repose is 1 year, other proportionings are consistent with embodiment 1.
5 vitamin E additive amount of comparative example is 0, and tea polyphenol-palmitate additive amount is 0.3 g, other proportionings and embodiment 1
Unanimously.
6 tea polyphenol-palmitate additive amount of comparative example is 0, and vitamin E additive amount is 0.3 g, other proportionings and embodiment 1
Unanimously.
The behavior pattern of embodiment 1-6 and the camellia soothing oil of comparative example 1-6 treatment scalds, including viscosity, I degree for the treatment of are scalded
Hinder effect, the light II degree of scald effect for the treatment of, antioxidative stabilizer, is specifically listed in table 2.
The behavior pattern of the camellia soothing oil of the treatment scald of 2 embodiment 1-6 of table, comparative example 1-6
。
Used test method is as follows in table 2:
(1) viscosity of the camellia soothing oil for the treatment of scald measures using digital display viscosimeter
(2) it is to carry out smearing experiment in the affected part of experimental subjects small white mouse to treat I degree of scald effect, and specific implementation is as follows：
A experimental procedures
12 groups of experimental group is chosen, blank group one group of every group of sample, 5 small white mouses on the hind leg of every small white mouse are cooked shaving and do I
Spend scald processing, the erythema of scald wound about diameter 2cm, every group after being cooled down with 20 DEG C of cold water, with embodiment 1-6, comparative example
The camellia soothing oil of the made treatment scalds of 1-6 is handled, and per 12h, observation is primary, and data are recorded to fully recover sample number.
B results count
Table 3 lists I degree of scald effect situation for the treatment of of embodiment 1-6 and the camellia soothing oil of comparative example 1-6 treatment scalds, with
It does not deal with as blank control, records cure time.
I degree of scald effect situation of the camellia soothing oil of the treatment scald of table 3
。
The experimental results showed that embodiment 1-6 plays the role of highly significant in I degree of scald effect for the treatment of, comparative example is fullyed recover from an illness
More speed is slower than embodiment, and blank group is obviously fully recovered, speed is slower.
（3）II degree of scald effect for the treatment of is to carry out smearing experiment in the affected part of experimental subjects small white mouse, and specific implementation is as follows：
A experimental procedures
12 groups of experimental group is chosen, blank group one group of every group of sample, 5 small white mouses on the hind leg of every small white mouse are cooked shaving and do II
Scald processing is spent, the bubble of scald wound about diameter 2cm, every group after being cooled down with 20 DEG C of cold water, is pricked a blister with a needle with sterile needle, is used
The camellia soothing oil of the made treatment scald of embodiment 1-7, comparative example 1-6 is handled, and per 12h, observation is primary, with sample of fully recovering
It counts to record data.
B results count
Table 4 lists the light II degree of scald effect feelings for the treatment of of embodiment 1-6 and the camellia soothing oil of comparative example 1-6 treatment scalds
Condition records cure time not deal with as blank control.
Light II degree of scald effect situation of the camellia soothing oil of the treatment scald of table 4
。
The experimental results showed that embodiment 1-6 plays the role of highly significant on treating light II degree of scald effect, comparative example
Speed of fully recovering is slower than embodiment, and blank group speed of obviously fully recovering is slower, and occurs suppuration inflammation phenomenon on day 1.
(4) antioxidative stabilizer test method：
Test objective：The camellia soothing oil of the treatment scald of Observe and measure the embodiment of the present invention 1-6, comparative example 1-6 is in difference
Oxidation induction time under high-temperature condition calculates that oxidation stability is fixed and shelf life, is the treatment scald of the embodiment of the present invention
Camellia soothing oil provides product stability foundation.
Test apparatus：Oil oxidative stability analyzer（743 types are led in Switzerland ten thousand）
Experimental procedure：Randomly select the embodiment of the present invention 1-6, the camellia soothing oil of comparative example 1-6 weigh respectively in right amount in
100, oxidation induction time is measured at 110,120,130 DEG C, pass through system plug-in and export shelf life.
Test result is shown in Table 5.
The camellia soothing oil antioxidative stabilizer experimental result of the treatment scald of table 5
。
Conclusion (of pressure testing)：The anti-inflammatory stagnation resolvation camellia soothing oil of various embodiments of the present invention has significant oxidation stability.
Result listed by table 2,3,4 illustrates that the present invention treats the camellia soothing oil of scald, and modest viscosity scalds I degree and light
II degree of scald has significant therapeutic effect, and antioxidative stabilizer is good, is a effective skin care item for being suitable for treating scald.
In addition, by the camellia soothing oil of the treatment scald obtained by embodiment 1-6, by examining microbiological indicator, health to refer to
Mark《Cosmetics safety technical specification》（Version in 2015）, obtain testing result shown in following table 6：
Table 6
。
The present invention treats the camellia soothing oil toxicology test of scald：Skin irritation test（Multiple skin irritation examination
It tests）
Test objective：Observe rabbit intact skin long-time multiple-contact tested material（The treatment scald of the embodiment of the present invention
Camellia soothing oil）Generated skin irritation reaction afterwards, the camellia soothing oil for the treatment scald of the embodiment of the present invention carry
For safety foundation.
Test basis：《Cosmetics health specification》Version in 2007
Test method：White New Zealand rabbits 8 are selected, are randomly divided into 2 groups, every group 4.A groups:Intact skin group, B groups:Olive
Sunflower oil control group.Family's rabbit back backbone both sides hair is cut for 24 hours before experiment, skin surface, unhairing model are not damaged in cropping
It encloses for 3cm × 3cm, application area is 2.5cm × 2.5cm., mountain of the tested material group to the treatment scald of various embodiments of the present invention
Tea soothing oil takes tested material 0.5ml to be coated directly on the side of back backbone, and the other side applies 0.5ml control group olive sunflower oils, often
It is smeared 1 time, and 14d is continuously smeared.Since second day, cropping when smearing every time removed residual tested material with olive sunflower oil.
After one hour observation as a result, according to《Cosmetics safety technical specification》The skin irritation test table scoring of version in 2015, it is right
It is equally handled according to area and trial zone.
Evaluation of result：Every rabbit average integral daily is calculated according to the following formula, is pierced by specification list deciding rabbit skin
Swash intensity, and observes other toxic effects in addition to irritation.
。
Test result：Tested material carried out in the multiple skin irritation test observation period, gave various embodiments of the present invention
Treatment scald camellia soothing oil after, rabbit has no erythema, oedema.Have no systemic toxicity profiles performance and death condition, animal body
Increase again, on breathing, cycle, central nervous system, four limbs activity etc. without influence.
Conclusion (of pressure testing)：The camellia soothing oil of the treatment scald of various embodiments of the present invention is to white New Zealand rabbits intact skin
It is nonirritant.
Claims (4)
1. a kind of camellia soothing oil for treating scald, which is characterized in that uniformly mixed by following component according to mass fraction and
At：80~85 parts of cold press camellia oil, 15~20 parts of Chinese herbal medicine, 0.3-0.5 parts of antioxidant content.
2. treating the camellia soothing oil of scald according to claim 1, it is characterised in that：The Chinese herbal medicine is according to mass parts
Number is uniformly crushed and is mixed by 5~10 parts of Flos Hibisci Mutabilis, 3~5 parts of raw rhubarb, 3~5 parts of Radix Sangusorbae.
3. treating the camellia soothing oil of scald according to claim 1, it is characterised in that：The antioxidant content is according to matter
Amount number is mixed by 0.2-0.3 parts of vitamin E, 0.1-0.2 parts of tea polyphenol-palmitate.
4. treating the preparation method of the camellia soothing oil of scald according to claim 1, it is characterised in that include as follows successively
Step：
1）It takes freeze-drying mode to be dried fresh herbal raw material, is pre-chilled 10-20 DEG C, 4-5 hours；Drying condition：
20-25 DEG C of baffle temperature, 10-15 hours；
2）It pulverizes and fragmentates after drying；
3）Herbal raw material is weighed, is immersed in cold press camellia oil, antioxidant content is added；
4）By nitrogen charging in container, by bottle sealing, it is positioned at shady and cool drying and stands dissolution；
5）After 2-3 to be placed, medicinal herb soak oil is filtered, the camellia soothing oil for the scald that obtains medical treatment.
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| CN201810984840.4A CN108771647A (en) | 2018-08-28 | 2018-08-28 | Treat the camellia soothing oil and preparation method thereof of scald |
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| CN201810984840.4A CN108771647A (en) | 2018-08-28 | 2018-08-28 | Treat the camellia soothing oil and preparation method thereof of scald |
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| CN201810984840.4A Pending CN108771647A (en) | 2018-08-28 | 2018-08-28 | Treat the camellia soothing oil and preparation method thereof of scald |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109394680A (en) * | 2018-12-29 | 2019-03-01 | 赣南医学院 | Salve for treating burn and scald and its preparation method and application |
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| CN103263496A (en) * | 2013-06-17 | 2013-08-28 | 李永泉 | Medicinal composition for treating burn |
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| CN109394680A (en) * | 2018-12-29 | 2019-03-01 | 赣南医学院 | Salve for treating burn and scald and its preparation method and application |
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