CN108770971A - A kind of relieving alcoholism and protecting liver chocolate and preparation method thereof - Google Patents
A kind of relieving alcoholism and protecting liver chocolate and preparation method thereof Download PDFInfo
- Publication number
- CN108770971A CN108770971A CN201810510841.5A CN201810510841A CN108770971A CN 108770971 A CN108770971 A CN 108770971A CN 201810510841 A CN201810510841 A CN 201810510841A CN 108770971 A CN108770971 A CN 108770971A
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- Prior art keywords
- powder
- chocolate
- alcohol
- liver
- relieving alcoholism
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
- A23G1/48—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/32—Cocoa products, e.g. chocolate; Substitutes therefor characterised by the composition containing organic or inorganic compounds
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- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
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Abstract
A kind of relieving alcoholism and protecting liver chocolate and preparation method thereof, the pueraria lobata for alleviating headache and protect liver is added on the basis of chocolate base starting material, Schisandra chinensis, the fruit of Chinese wolfberry, Radix Glycyrrhizae, the integration of drinking and medicinal herbs substance such as honey, the present invention is to use kudzu root extract, a variety of extracts such as Schisandra chinens P.E carry out scientific and reasonable collocation and manufactured functional chocolate, its advantage is that easy to carry, convenient for edible, there is stronger dispelling effects of alcohol, there is the depression effect caused by antagonism ethylism, there is the effect that accelerating alcohol decomposes, there is protective effect to liver, also it can alleviate caused headache after drinking.
Description
Technical field
The present invention relates to food technology field, more particularly to a kind of relieving alcoholism and protecting liver chocolate and its preparation side
Method.
Background technology
Acute alcoholism, is commonly called as drunk, refers to once drinking into excess ethyl alcohol, and the absorption of ethyl alcohol in vivo is more than metabolism,
Absorbed ethyl alcohol enters blood circulation, enters body parasthenia caused by brain by blood-brain barrier and nervous centralis inhibits
State.Alcoholism can be in various degree dysfunction and the visceral organ injury for causing multiple organ, wherein with the damage of stomach and liver
Hinder most commonly seen.
High concentration ethanol can directly corrode stomach lining, cause Acute Gastric Mucosal inflammation, mucous membrane occur oedema, hyperemia, erosion,
Bleeding even ulcer etc., in addition, acute liver tissue injury can also be caused by being absorbed into internal ethyl alcohol and its metabolite acetaldehyde etc..
Metabolism of the ethyl alcohol in liver is participated in by a variety of enzyme systems, such as：Hydrogen peroxide oxidation enzyme system, microbody oxidation of ethanol enzyme system
System, alcohol dehydrogenase enzymatic oxidising system etc., wherein alcohol dehydrogenase enzyme system participates in vivo about 80% wine metabolism.Into internal
Alcohol is most of to be oxidized to acetaldehyde by alcohol dehydrogenase (ADH), and acetaldehyde is converted into acetic acid by acetaldehyde dehydrogenase (ALDH), most laggard
Enter tricarboxylic acid cycle and resolves into CO2And H2O is excreted.
In above-mentioned reaction system, the ADH and ALDH that are primarily present in liver and stomach are the key enzymes of alcohol metabolism.ADH
It is a kind of zinc-containing metal enzyme, is widely present in people and mammalian liver, is the main enzyme that biological oxidation occurs for catalysis ethanol,
Mainly by internal oxidation of ethanol at acetaldehyde.ADH activity levels directly affect the concentration of ethyl alcohol or acetaldehyde in body, and ALDH is to urge
Change the main enzyme that acetaldehyde forms acetic acid, the harmful acetaldehyde of organism will can be converted.ALDH seems particularly during relieving the effect of alcohol
Important, a series of alcoholism symptoms after drinking such as blush, are restless, palpitating quickly, excitement is mainly due to second in blood
The raising of aldehyde concentration rather than the raising of concentration of alcohol, acetaldehyde have strong cytotoxicity, with acute liver damage and Acute gastric injury
It is closely related.What is relieved the effect of alcohol focuses on inhibiting absorbing, accelerates metabolism, enhances alcohol metabolism key enzyme, accelerates ethyl alcohol and metabolism production
The decomposition of object acetaldehyde, external CO can be excluded by being allowed to be decomposed into2And H2O, and most importantly enhancing catalysis in the process
The aldehyde dehydrogenase activity of acetaldehyde.
Alcoholism, about its mechanism of poisoning and clinical manifestation, domestic and foreign scholars have done a lot of research work, and for
The treatment of alcoholism, research emphasis both domestic and external lay particular emphasis on chronic alcoholism, the drug therapy in relation to acute alcoholism,
It then studies less.Currently, being mainly both at home and abroad anti symptom treatment to the treatment of acute alcoholism, lack effective antialcoholic drugs,
And clinically lacking active preventive means mostly based on passive therapy, Chinese medicine is well worth doing in this regard.
In recent years, with the improvement of living standards and the change of diet structure, liquor production and popularity of wine year by year on
It rises, the incidence for the relevant disease that alcoholism is caused also is in the trend increased year by year, therefore, finds and researches and develops natural, nothing
Poison, the effective food with dispelling alcohol and protection of liver and stomach have practical significance.Presently commercially available disintoxicating product, as electuary,
Alcohol-decomposing beverage and syrup confirm that some effects are poor, and taste is bad and is inconvenient to take by the feedback information of most consumers
Band, it is inconvenient and cumbersome that some products are eaten, and affects the effect of product.
Therefore, how to provide that a kind of taste is good, edible and relieving alcoholism and protecting liver chocolate and preparation method thereof easy to carry is
The problem of those skilled in the art's urgent need to resolve.
Invention content
In view of this, the present invention provides a kind of easy to carry, masses' degree of liking is higher and convenient, has and relieves the effect of alcohol
The chocolate of function.
In order to achieve the above object, the present invention adopts the following technical scheme that：
A kind of relieving alcoholism and protecting liver chocolate, includes the component of following mass percentage：
Preferably, in a kind of above-mentioned relieving alcoholism and protecting liver chocolate, include the component of following mass percentage：
The present invention also provides a kind of preparation methods of relieving alcoholism and protecting liver chocolate, include the following steps：
(1) pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry, Radix Glycyrrhizae are separately dried crushing.
(2) kudzu-vine root powder is pressed into solid-liquid ratio 1:15-25 is right with 60-80% edible alcohols refluxing extraction 2-3 times, each 1-3h
Obtained extracting solution is concentrated under reduced pressure, and alcohol is waved to the greatest extent, medicinal extract is obtained, through 60-70 DEG C of low temperature drying, obtains kudzu root extract powder.
(3) Fructus Schisandrae Chinensis powder is pressed into solid-liquid ratio 1:4-6 addition 70-90% edible alcohols, refluxing extraction 2-4 times, each 1-2h,
Filtering is concentrated under reduced pressure obtained extracting solution, alcohol is waved to the greatest extent, medicinal extract is obtained, through 60-70 DEG C of low temperature drying, obtains Schisandra chinensis
Extract powder.
(4) medlar powder is pressed 1:The ratio addition drinking water of 8-12,90-100 DEG C of heating extraction 2-4 times, each 1-3h,
Merging filtrate, concentration, 60-70 DEG C of low temperature drying obtain Fructus lycii P.E powder.
(5) Radix Glycyrrhizae powder is pressed 1:Drinking water is added in 25-35 solid-liquid ratios, and it is standby to filter out solution by 70-90 DEG C of hot water extraction 2-4h
With filtering out the secondary extraction of the dregs of a decoction, solid-liquid ratio 1:25-35, hot water extraction 2-3h, filter out solution for standby, filter out solution merging twice,
Concentration, 60-70 DEG C of low temperature drying obtain licorice powder.
(6) chocolate mass abrasive lapping machine normalization sanitized, grinder running after, input cocoa liquor, cocoa butter, can
Can powder, add pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry, Radix Glycyrrhizae extraction powder and honey, be in semi-finished product after sticky, pour into mold, it is cold
Freeze, dry, disinfection.
Preferably, in a kind of above-mentioned preparation method of relieving alcoholism and protecting liver chocolate, include the following steps：
(1) pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry, Radix Glycyrrhizae are separately dried crushing.
(2) 500g kudzu-vine root powders are pressed into solid-liquid ratio 1:20, with 85 DEG C of 80% edible alcohol refluxing extraction 2 times, each 2h.It obtains
Extracting solution be concentrated under reduced pressure, by alcohol wave to the greatest extent, obtain medicinal extract, through 65 DEG C of low temperature dryings, obtain kudzu root extract powder 75g.
(3) 500g Fructus Schisandrae Chinensis powders are pressed into solid-liquid ratio 1:5 are added 80% edible alcohols, 85 DEG C of refluxing extractions 2 times, every time
1.5h.Filtering, obtained extracting solution are concentrated under reduced pressure, and alcohol is waved to the greatest extent, medicinal extract is obtained, through 65 DEG C of low temperature dryings, obtains Schisandra chinensis
Extract powder 185g.
(4) 500g medlar powders are pressed 1:Drinking water is added in 10 ratio, and 95 DEG C of heating extractions 2 times, each 1h merge two
Secondary filtrate, concentration, 65 DEG C of low temperature dryings obtain Fructus lycii P.E powder 65g.
(5) 500g Radix Glycyrrhizae powder is pressed 1:Drinking water is added in 30 solid-liquid ratios, and 80 DEG C of hot water extraction 3h filter out solution for standby,
Filter out the secondary extraction of the dregs of a decoction, solid-liquid ratio 1:30,2.5h, solution for standby is filtered out, filters out solution merging, concentration, 65 DEG C of low temperature twice
It is dry, obtain licorice powder 50g.
(6) chocolate mass abrasive lapping machine normalization sanitized, grinder running after, input cocoa liquor, cocoa butter, can
Can powder, add pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry, Radix Glycyrrhizae extraction powder and honey, be in semi-finished product after sticky, pour into mold, it is cold
Freeze, dry, disinfection.
Wherein, pueraria lobata：It is sweet in flavor, pungent, it is cool in nature, there is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption, promote the production of body fluid to quench thirst, the work(of Shengyang Zhixie, being usually used in table
Demonstrate,prove fever, stiff nape and back, measles without adequate eruption, pyreticosis is thirsty, the deficiency of Yin is quenched one's thirst, heat is purged heat dysentery, splenasthenic diarrhea etc..
Numerous research has shown that kudzu root extract has and inhibits alcohol absorption amount, acceleration of alcohol metabolism, improves to alcohol
Dosis tolerata reduces the effects that death rate and reduction are to liver damage, wherein using general flavone as principle active component.Pueraria lobata can pass through
It removes free radical and anti peroxidation of lipid approach and reduces blood viscosity, promote blood circulation, ethyl alcohol is made to accelerate excretion, reduce to liver
Dirty and other each systems damages, the effects that playing liver protection brain tonic.The influence of Central nervous system stimulant and process of inhibition
It is one of the important channel relieved the effect of alcohol, the effect of Pueraria Flavonid Central nervous system shows as Small Dose Excitement, large dosage suppression
System.Puerarin has apparent antagonism to body internal oxidition reaction caused by alcohol, to have to the cell of body vitals
Protective effect, Puerarin can inhibit the generation of Alcoholic Femoral Head Necrosis, and can prevent osteonecrosis.
Schisandra chinensis：It is sour, sweet, it is warm-natured, there is the effect of convergence astringent method, nourishing generate fluid, kidney calming.It is usually used in void of coughing long
Asthma, emission, enuresis frequent micturition, endless diarrhea, spontaneous sweating, injury thirst, Heat Diabetes, palpitation and insomnia etc..Schisandraceae
The chemical composition of plant is mainly lignanoid, volatile oil, polysaccharide and triterpene compound, especially Dibenzocyclooctene lignan
It is mainly distributed in Schisandraceae, is the characteristic constituents of the section, also known as Schisandra chinensis lignans, there is liver protection drop
Enzyme adjusts central nervous system isoreactivity.
The fruit of Chinese wolfberry：It is sweet in flavor, mild-natured, nourishing liver and kidney, benefiting shrewd head.Matrimony vine has various pharmacological actions and bioactivity
Function, as main bioactie agent in the fruit of Chinese wolfberry, polysaccharides can promote immunoregulation effect, enhance every cell and exempt from
Epidemic disease index has strengthen immunity, anti-aging and antifatigue, raising antibody, liver protection eyeshield and other effects, it has also become health food
An important functional additive.
Radix Glycyrrhizae：Radix Glycyrrhizae is sweet in flavor, mild-natured, the thoughts of returning home, lung, spleen, stomach, has and invigorates the spleen and benefits qi, and clearing heat and detoxicating, expelling phlegm and arresting coughing delays
Anxious analgesic, the function of coordinating the drug actions of a prescription are suddenly ached for weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, de- abdomen, four limbs contraction
Bitterly, carbuncle swells lump is malicious, alleviates drug toxicity, is strong.Its main pharmacological is calm cough-relieving and hepatoprotective effect.
Honey is sweet in flavor mild-natured, and from ancient times just by the food as integration of drinking and medicinal herbs, the main component of honey is carbohydrate, and content is up to
75% or more, wherein 2 kinds of monosaccharide of glucose and fructose account for about the 97%~98% of total glucides.The collaboration of honey various composition is made
With, impart honey antibacterial, it is anti-inflammatory, anti-oxidant, promote the various actives such as wound healing.Containing a kind of most of in honey component
The no fructose of fruit, it can promote the decomposition of alcohol to absorb, therefore be conducive to Quick sobering, and release the headache after drinking
Sense.Glucose, vitamin, magnesium, phosphorus, calcium in honey can adjust nervous function, alleviate nervous, promotion sleep.
Pueraria lobata and Schisandra chinensis compatibility, have relieving alcoholism and protecting liver, promote the production of body fluid to quench thirst, kidney calming, enhancing immunity of organisms, memory
With the effect for improving sleep；The fruit of Chinese wolfberry and Radix Glycyrrhizae compatibility, clear liver and improve vision, clearing heat and detoxicating, blood fat-reducing blood pressure-decreasing, calm cough-relieving and guarantor
Liver；Honey has antibacterial, function that is anti-inflammatory, anti-oxidant, promoting wound healing, the fructose in honey component to be conducive to Quick sobering,
And release the headache sense after drinking.
Show through pharmacological evaluation：The relieving alcoholism and protecting liver chocolate of the present invention is equal to superoxide dismutase (SOD enzymes) activity ratio
Value can be eliminated or be mitigated for 35.52%, SOD enzymes causes lipid peroxy by alcohol by enzyme or non-enzyme system generation oxygen radical
The damage of change illustrates that the compatibility has the function of removing peroxide and protection cell well from oxidative damage, and can show
It writes and increases alcohol dehydrogenase (ADH) activity ratio.
Together, cool temperature is complementary, respectively holds its effect, and taste is sour-sweet for traditional Chinese medicine of the five flavours compatibility of the present invention, and so that this product is become has solution
The health product of wine protect liver and other effects.
Compared with prior art, the attainable advantageous effect of above technical scheme institute of the present invention is：
1. the present invention is that the traditional Chinese medicine extraction components such as pueraria lobata are added on the basis of former chocolate material, there is apparent effect of relieving the effect of alcohol
On the one hand fruit has healthcare function, on the one hand several persons proportionally coordinate, and as the integration of drinking and medicinal herbs substance of Antialcoholic liver-protecting, have
Good effect.
2. using this product after drinking, the metabolism of alcohol can be accelerated, accelerate digestion and diuresis, liver can be protected and disappeared
Change system.
3. the present invention is not only had good mouthfeel while reducing Sugar intake it is not necessary that carbohydrate is added but is replaced using honey
Amount.
4. the preparation method of the present invention is simple, process equipment is required relatively low.
5. the more similar disintoxicating product of the present invention can be eaten in all case the features such as having and be convenient for carrying, easily eat,
There is stronger dispelling effects of alcohol, there is the depression effect caused by antagonism ethylism, there is the effect that accelerating alcohol decomposes, has to liver
There is protective effect, can also alleviate caused headache after drinking.
6. the present invention is that the integration of drinking and medicinal herbs substance of Antialcoholic liver-protecting is added on the basis of chocolate, taste is good, suitable for each
Class crowd.
7, it eats after drinking, can be absorbed in the stomach of ethyl alcohol and two links of metabolic detoxification play a role, second in blood can be made
Alcohol, acetaldehyde concentration decline, and inhibit the raising of urea nitrogen (BUN), to play antialcoholism action.Traditional Chinese medicine extraction component passes through anti-freedom
Base, it is possible to reduce destruction of the free radical to liver plasma membrane reduces Ethanol concentration in rat blood, mitigates ethyl alcohol to human nerve system
Effective drop alcohol effects of dispelling effects of alcohol and protecting liver is played in the damage of system, digestive system etc..
Specific implementation mode
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
The every other embodiment that technical staff is obtained without making creative work belongs to the model that the present invention protects
It encloses.
The present invention provides a kind of relieving alcoholism and protecting liver chocolate, the raw material of each hectogram finished product is：Kudzu root extract powder 10
~12 grams；7~9 grams of Schisandra chinens P.E powder；7~9 grams of Fructus lycii P.E powder；3~5 grams of licorice powder；It can
It can 35~37 grams of liquid block；15~17 grams of cocoa butter；12~14 grams of honey；3~5 grams of cocoa power.
A kind of preparation process flow of above-mentioned relieving alcoholism and protecting liver chocolate is:
(1) pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry, Radix Glycyrrhizae are separately dried crushing.
(2) 500g kudzu-vine root powders are pressed into solid-liquid ratio 1:20, with 85 DEG C of 80% edible alcohol refluxing extraction 2 times, each 2h.It obtains
Extracting solution be concentrated under reduced pressure, by alcohol wave to the greatest extent, obtain medicinal extract, through 65 DEG C of low temperature dryings, obtain kudzu root extract powder 75g.
(3) 500g Fructus Schisandrae Chinensis powders are pressed into solid-liquid ratio 1:5 are added 80% edible alcohols, 85 DEG C of refluxing extractions 2 times, every time
1.5h.Filtering, obtained extracting solution are concentrated under reduced pressure, and alcohol is waved to the greatest extent, medicinal extract is obtained, through 65 DEG C of low temperature dryings, obtains Schisandra chinensis
Extract powder 185g.
(4) 500g medlar powders are pressed 1:Drinking water is added in 10 ratio, and 95 DEG C of heating extractions 2 times, each 1h merge two
Secondary filtrate, concentration, 65 DEG C of low temperature dryings obtain Fructus lycii P.E powder 65g.
(5) 500g Radix Glycyrrhizae powder is pressed 1:Drinking water is added in 30 solid-liquid ratios, and 80 DEG C of hot water extraction 3h filter out solution for standby,
Filter out the secondary extraction of the dregs of a decoction, solid-liquid ratio 1:30,2.5h, solution for standby is filtered out, filters out solution merging, concentration, 65 DEG C of low temperature twice
It is dry, obtain licorice powder 50g.
(6) chocolate mass abrasive lapping machine normalization sanitized, grinder running after, input cocoa liquor, cocoa butter, can
Can powder, add pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry, Radix Glycyrrhizae extraction powder and honey, be in semi-finished product after sticky, pour into mold, it is cold
Freeze, dry, disinfection.
Chocolate formula components are food and edible drug, are formed through scientific matching, it is by stringent careful
Zoopery, and the application verification in suitable range crowd are below relieving alcoholism and protecting liver chalk of the present invention by being iteratively improved
The testing result of power.
1. physical and chemical index
The physical and chemical index for the Antialcoholic liver-protecting chocolate that the present invention obtains is as shown in table 1：
Table 1
| Project | With reference to index | Testing index |
| Moisture % | ≤1.5 | 1 |
| Protein % | ≥9.2 | 10.8 |
| Fatty % | ≤32.8 | 26.3 |
| Total reducing sugar (in terms of fructose) % | ≥20 | 54.9 |
| Total plate count (cfu/g) | ≤100 | 60 |
| Coliform (MPN/100g) | ≤6 | 3 |
| Pathogenic bacteria | It must not detect | It is not detected |
| Arsenic (mg/kg) | ≤0.2 | 0.02 |
| Lead (mg/kg) | ≤0.3 | 0.001 |
| Copper (mg/kg) | ≤5 | 0.5 |
2. organoleptic indicator
The Antialcoholic liver-protecting chocolate of the present invention sensory evaluation is subjected to commercially available chocolate, this experiment subjective appreciation exists
It is completed in food organoleptic evaluation room, 20 students is invited to form evaluation group, the purpose and meaning of this first clear experiment and sense
The index and points for attention of official's evaluation.Evaluation is individually carried out by each evaluation member every time, and mutually contact ac, sample are not evaluated
Between gargled with clear water.
The definition of subjective appreciation index is：Hardness：It is to bite the power that sample is applied with molar first；Brittleness：By one
Small-sized products are put between molar, slowly bite away and continue to the appearance of the unexpected and continuous Fragmentation Phenomena of cake dry construction,
The degree that product is broken into fractionlet is assessed under occlusion rate as consistent as possible；Chewiness：Chewing sample can gulp down
The workload of pharynx；Cohesion (is to bite sample with molar to make the degree of its deformation (rather than pulverize, split broken, broken)；Elasticity：
It is so that it is restored to the degree of original state sample part force with molar；Overall acceptance：It is the receiving to population of samples
Degree.
Evaluation mode is divided using 60 points of systems, hardness 10, and brittleness 10 is divided, and chewiness 10 divides, and cohesion 10 is divided, 10 points of elasticity,
Overall acceptance 10 divides.In order to reduce from many factors being measured between forming concept as hobby with preference, experience, advertisement,
The influence to inspection result such as price, is tested using double-blind study.Password number is carried out to sample, sample is also randomized.
Table 2
| Types of chocolate | Feature description | Scoring |
| Antialcoholic liver-protecting chocolate of the present invention | It in sepia, gives off a strong fragrance, mouthfeel is soft, and taste is suitable | 57.8 |
| Kiss cookies milk chocolate when good | It is creamy white, it is sweet, there is silk to slide mouthfeel | 57.3 |
| Switzerland's lotus dark chocolate bar | Darkly sepia or brownish black, bitter, mouthfeel children are slided | 57.9 |
| Dove milk chocolate | Mouthfeel that is sweet in brown or light brown, being slided with silk | 58.1 |
| Fei Lieluo filbert waffle chocolates | In brown, there is kernel fragrance, it is sweet | 56.8 |
3. nutritive index
The Antialcoholic liver-protecting chocolate of the present invention and the nutritional ingredient comparison result of commercial product are as shown in table 3, of the invention
Chocolate is compared with commercially available chocolate product, and protein content is high, and fat content is low, and energy is moderate.Pueraria lobota is added in product
Root, Schisandra chinensis, matrimony vine, Radix Glycyrrhizae active ingredient polysaccharide and flavone compound, have the function of Antialcoholic liver-protecting.
Table 3
4. ethyl alcohol conservation rate
Blank:56% ethyl alcohol 1mL and distilled water 2mL are added in 10mL test tubes.
Experiment：Antialcoholic liver-protecting chocolate 1g, is added 10mL distilled water, heats mixing in test tube, 3000r/min after 10min
15min is centrifuged, supernatant 1mL is collected, 56% ethyl alcohol 1mL is added, 1mL distilled water is added after mixing, is used after suitably diluting
Gas chromatography measures ethanol content in liquid.
Ethyl alcohol conservation rate calculates as follows：Ethyl alcohol conservation rate=[(blank value-test value)/blank value] × 100%
As a result：Antialcoholic liver-protecting chocolate is 92% to the conservation rate of ethyl alcohol, chocolate-enrobed of relieving the effect of alcohol ethyl alcohol so that free second
Alcohol amount reduces, and inhibits the body absorption for delaying ethyl alcohol.
5.SOD Enzyme assays
Superoxide dismutase (SOD) can make alcohol pass through enzyme or non-enzyme system generation oxygen radical, cause lipid mistake
Oxidation, can eliminate the harmful substance that body generates in metabolic processes, have and remove peroxide and protection cell from oxygen
Change the important function of damage, therefore, research drug can reflect that chocolate protects liver effect to SOD activity influences.
SOD activity is measured using pyrogallol autoxidation method, autoxidation can occur under alkaline condition using pyrogallol,
SOD is added and inhibits mouse thymus cells ability, the absorbance of solution is measured at 325nm.
Three batch chocolates are taken, every batch of 10,3000r/min centrifuges 15min after being dissolved in respectively in 100mL hot water,
Supernatant is taken, its SOD activity is measured.
Calculation formula is as follows：
In formula：△A325Mouse thymus cells rate
ΔA′325Sample liquid or SOD enzyme solutions inhibit mouse thymus cells rate
Enzyme solution added by V- inhibits mouse thymus cells rate
The extension rate of D- enzyme solutions or sample liquid
V1Sample liquid total volume, unit are milliliter (mL)
M- sample liquid quality, unit are gram (g)
4.5- reaction solution total volumes, unit are milliliter (mL)
The activity ratio formula of enzyme is as follows：
Table 4
The mean value of Antialcoholic liver-protecting chocolate SOD vigor is 178.1 (U/mL), is 35.52% to SOD enzyme activition rate mean values,
Illustrate that relieving alcoholism and protecting liver chocolate has to remove peroxide well and protect cell from the important function of oxidative damage.
6. influence of the relieving alcoholism and protecting liver chocolate to ADH enzymatic activitys
Alcohol dehydrogenase (ADH) is the main enzyme that human body decomposes ethyl alcohol, is distributed mainly on liver and gastrointestinal tract.Therefore,
Research drug can reflect influence of the drug to alcohol metabolism to ADH activity influences.
Alcohol dehydrogenase activity assay method:The present invention is slightly improved using watt Le one Huo He (vaell&Hoch) method
After detect alcohol dehydrogenase activity.Sodium pyrophosphate buffer solution 1.5ml, NAD are added in test tube with ground stopper+1.0ml, ethyl alcohol 0.5ml,
5g chocolates are dissolved in 100mL hot water, rear 3000r/min centrifuges 15min, takes supernatant, be added supernatant 0.1,0.2,
0.3,0.4ml, after mixing at 37 DEG C, capping incubates 5min.ADH 0.l ml are added in test tube with ground stopper after incubation immediately, it is right
ADH solution is replaced with distilled water in looking after, 37 DEG C of gentle 5min after shaking up measure absorbance (A340) value, are read later every 30s
Number is primary, METHOD FOR CONTINUOUS DETERMINATION 5min.Zero is set up with control tube, it is to measure the active blank control groups of ADH to be not added with supernatant then.Meter
Calculate average absorbance value △ A/min per minute.
Surveyed experimental data withIt indicates, is examined using t and carry out statistical analysis, different samples are active to ADH
Influence is shown in Table 5 (n=4).
Table 5
The experimental results showed that, between same sample various dose, with the increase of dosage, ADH activation effects are increased above
Add, in 0.4ml dosage, chocolate supernatant is 50.33% to ADH activity ratios, illustrates that chocolate has the work of activation ADH enzymes
With.
7. Antialcoholic liver-protecting chocolate and commercial product pueraria lobata trifoliate orange Dulcis soft capsules, the edible information of nine Ba Gegen Dealcoholic sobering-up pieces are anti-
Feedback 100
Work post is as follows in 100 eaters：40 people of worker, 30 people of student, 40 people of peasant.
Age distribution is as follows in 100 eaters：20 years old to 30 years old 30 people, 30 years old to 50 years old 40 people, 50 years old or more 30 people.
Eater's health condition：Normal 85 people of person of physical condition has stomach trouble, digestion bad, liver dysfunction to have 15 people.
Effect judgment basis is：
(1) effective：Usually no drinking person drinks 50 degree of two two halves of white wine, after drinking after random edible tri kind disintoxicating product
Speech, feeling and behavior all restore normally, with drink before be no different, have no adverse reaction.
(2) effectively：Usually without alcohol drinking patterns person, 50 degree of two two halves of white wine are drunk, random edible tri kind is relieved the effect of alcohol production after drinking
Product, slightly dizzy, speech performance is normal, and stomach is micro- discomfort
(3) invalid：50 degree of two two halves of white wine are drunk, random edible tri kind disintoxicating product after drinking, spirit is excited, say more,
Language of taking action is abnormal, drunk reaction occurs；Feedback result is shown in Table 6.
Table 6
(1) eating effect is unrelated with work post.
(2) the not good enough person of digestive tract function, with healthy person eating effect without larger difference.
The present invention is a kind of chocolate of Antialcoholic liver-protecting, and contained become is traditional Chinese medicine extraction component and food, without anyization
Additive is learned, preservative, by scientific matching, it has liver-protective function, in good taste, and quality is fine and smooth.It eats after drinking, energy
Enough stomach in ethyl alcohol absorb and two links of metabolic detoxification play a role, and ethyl alcohol in blood, acetaldehyde concentration can be made to decline, inhibit urine
The raising of plain nitrogen (BUN), to play antialcoholism action.Traditional Chinese medicine extraction component passes through Green Tea Extract, it is possible to reduce free radical is to liver
The destruction of cell membrane reduces Ethanol concentration in rat blood, mitigates damage of the ethyl alcohol to nerve system of human body, digestive system etc., rises
To effective drop alcohol effects of dispelling effects of alcohol and protecting liver.
Each embodiment is described by the way of progressive in this specification, the highlights of each of the examples are with other
The difference of embodiment, just to refer each other for identical similar portion between each embodiment.For device disclosed in embodiment
For, since it is corresponded to the methods disclosed in the examples, so description is fairly simple, related place is said referring to method part
It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (8)
1. a kind of relieving alcoholism and protecting liver chocolate, which is characterized in that include the component of following mass percentage：
2. a kind of relieving alcoholism and protecting liver chocolate according to claim 1, which is characterized in that including following mass percentage
Component：
3. a kind of preparation method of relieving alcoholism and protecting liver chocolate, which is characterized in that include the following steps：
(1) dry pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry and Radix Glycyrrhizae are crushed respectively, obtains the powder of each substance；
(2) concentration operation is extracted to pueraria lobata, Schisandra chinensis, the fruit of Chinese wolfberry and the powder of Radix Glycyrrhizae, obtains the extract of each substance
Powder；
(3) cocoa liquor, cocoa butter, cocoa power are put into chocolate mass abrasive lapping machine, add pueraria lobata, Schisandra chinensis, matrimony vine
Son, licorice powder and honey are in semi-finished product after sticky, pour into mold, freezing, dry, disinfection.
4. a kind of preparation method of relieving alcoholism and protecting liver chocolate according to claim 3, which is characterized in that step (2) includes
Following steps：
A. kudzu-vine root powder is mixed with alcohol by certain solid-liquid ratio, carries out refluxing extraction, extracting solution is concentrated under reduced pressure, medicinal extract is obtained,
Kudzu root extract powder is obtained after low temperature drying；
B. Fructus Schisandrae Chinensis powder is mixed with alcohol by certain solid-liquid ratio, carries out refluxing extraction, extracting solution is concentrated under reduced pressure, is soaked
Cream obtains Schisandra chinens P.E powder after low temperature drying；
C. medlar powder is mixed with drinking water by certain solid-liquid ratio, after heating extraction and concentration operation, low temperature drying obtains
To Fructus lycii P.E powder；
D. Radix Glycyrrhizae powder is mixed with drinking water by certain solid-liquid ratio, after hot water extraction and concentration operation, low temperature drying obtains
To licorice powder.
5. a kind of preparation method of relieving alcoholism and protecting liver chocolate according to claim 4, which is characterized in that step a is, by Pueraria lobota
Root powder presses solid-liquid ratio 1:15-25, with 60-80% edible alcohols refluxing extraction 2-3 times, each 1-3h subtracts obtained extracting solution
Pressure concentration, alcohol is waved to the greatest extent, medicinal extract is obtained, through 60-70 DEG C of low temperature drying, obtains kudzu root extract powder.
6. a kind of preparation method of relieving alcoholism and protecting liver chocolate according to claim 4, which is characterized in that step b is, by five
Taste powder presses solid-liquid ratio 1:70-90% edible alcohols, refluxing extraction 2-4 times is added in 4-6, and each 1-2h is filtered, carried to what is obtained
It takes liquid to be concentrated under reduced pressure, alcohol is waved to the greatest extent, medicinal extract is obtained, through 60-70 DEG C of low temperature drying, obtains Schisandra chinens P.E powder.
7. a kind of preparation method of relieving alcoholism and protecting liver chocolate according to claim 4, which is characterized in that step c is, by Chinese holly
Matrimony vine powder presses 1:Drinking water, 90-100 DEG C of heating extraction 2-4 times, each 1-3h is added in the ratio of 8-12, and merging filtrate concentrates,
60-70 DEG C of low temperature drying obtains Fructus lycii P.E powder.
8. a kind of preparation method of relieving alcoholism and protecting liver chocolate according to claim 4, which is characterized in that step d is, will be sweet
Press 1 in grass meal end:Drinking water is added in 25-35 solid-liquid ratios, and 70-90 DEG C of hot water extraction 2-4h filters out solution for standby, it is secondary to filter out the dregs of a decoction
Extraction, solid-liquid ratio 1:25-35, hot water extraction 2-3h, filter out solution for standby, filter out solution merging twice, concentration, 60-70 DEG C low
Temperature is dry, obtains licorice powder.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111557365A (en) * | 2019-03-19 | 2020-08-21 | 佳木斯大学 | Combined functional chocolate and preparation method thereof |
| CN111887332A (en) * | 2020-08-05 | 2020-11-06 | 重庆西大魔芋生物科技有限公司 | Konjak chocolate capable of dispelling effects of alcohol, protecting liver and benefiting intestines and preparation method thereof |
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| CN1530033A (en) * | 2003-03-17 | 2004-09-22 | 刘小蓉 | Health food additive and products for drunkard |
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| CN1530033A (en) * | 2003-03-17 | 2004-09-22 | 刘小蓉 | Health food additive and products for drunkard |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111557365A (en) * | 2019-03-19 | 2020-08-21 | 佳木斯大学 | Combined functional chocolate and preparation method thereof |
| CN111887332A (en) * | 2020-08-05 | 2020-11-06 | 重庆西大魔芋生物科技有限公司 | Konjak chocolate capable of dispelling effects of alcohol, protecting liver and benefiting intestines and preparation method thereof |
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