CN108743825A - A kind of composition for oral cavity and its preparation method and application containing bamboo-leaves flavones - Google Patents
A kind of composition for oral cavity and its preparation method and application containing bamboo-leaves flavones Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention belongs to oral hygienes, and in particular to a kind of composition for oral cavity and its preparation method and application containing bamboo-leaves flavones specifically includes：Bamboo-leaves flavones 1-10%, green-tea extract 1-4%, Cortex Ilicis Rotundae extract 0.1-1.0% and mulberry-leaf extract 0.5-1.5%.The present invention adds in bamboo-leaves flavones to composition, as toothpaste multifunction additive, has gentle flavor and mouthfeel, no flavour of a drug, bitter taste and penetrating odor, good water solubility, stay in grade can effectively resist acidolysis, pyrolysis and enzymolysis, suitable for toothpaste system.
Description
Technical field
The invention belongs to oral hygienes, and in particular to a kind of containing the composition for oral cavity of bamboo-leaves flavones and its preparation side
Method and application.
Background technology
Bamboo-leaves flavones also known as leaf of bamboo antioxidant are the biological flavones with physiological activity extracted from the leaf of bamboo,
It is a kind of efficient biological anti-oxidant, is nutrient needed by human.Bamboo-leaves flavones are with edible safety, stable quality at present
It is a kind of excellent health factor to be positioned the features such as unique with effect, and it is latent as the market of medicine intermediate to have an optimistic view of it
Power.In addition, the industry of bamboo extractive is applied to cosmetic industry.But the research of bamboo-leaves flavones is also in the shape to relatively lag behind
State.
Bamboo-leaves flavones are applied seldom in the oral cavity, have searched 2 examples at present：CN201610788440.7 reports one
Toothpaste and preparation method thereof with antibacterial action of the kind containing bamboo leaf flavone, CN200710063870.3 reports bamboo
Application of the leaf flavones in preparing oral cavity cleaning and nursing product.
Equal single use, causes product function single, user when current oral care product is using plant extracts
When needing to take into account a variety of oral conditions nursing, generally require to buy and use more money products, cost to increase simultaneously, it is often more important that
Use cumbersome, so that many user's user experiences are bad, nursing efficacy is bad.
Invention content
In consideration of it, the present invention provides a kind of composition for oral cavity and its preparation method and application containing bamboo-leaves flavones.This hair
Bright composition has clearing heat and detoxicating, inhibiting bacteria and diminishing inflammation, swelling and pain relieving, the bath of yin-nourishing profit, dispels halitosis, capable of clearing heat and reducing internal heat, fresh breath
Effect.
The present invention is achieved by the following technical solutions：
A kind of composition for oral cavity containing bamboo-leaves flavones, including：
Bamboo-leaves flavones 1-10%, green-tea extract 1-4%, Cortex Ilicis Rotundae extract 0.1-1.0% and mulberry-leaf extract 0.5-
1.5%.
Further, the ratio when bamboo-leaves flavones, green-tea extract, Cortex Ilicis Rotundae extract and mulberry-leaf extract are combined
For：3：2：0.3：1.
Further, the bamboo-leaves flavones purity is not less than 40%.
The green-tea extract purity is not less than 98%.
The Cortex Ilicis Rotundae extract derives from the bark or root skin of holly plant ilexrotunda.
The mulberry-leaf extract purity is not less than 40%.
Further, the composition for oral cavity containing bamboo-leaves flavones can be used for preparing paste, liquid and spray form
Equal oral care products, such as toothpaste, mouthwash, mouthspray product.
A kind of toothpaste containing bamboo-leaves flavones, based on mass fraction, including：Bamboo-leaves flavones 1-10%, green-tea extract 1-
4%, Cortex Ilicis Rotundae extract 0.1-1.0%, mulberry-leaf extract 0.5-1.5%, rubbing agent 1%-30%, moisturizer 1%-20%,
Thickener 0.3%-15%, adhesive 0.1%-2.5%, foaming agent 0.4%-4%, sweetener 0.01%-1%, preservative
0.05-0.5%, essence 1-2%, light green pigment 0.01-0.05%, surplus is deionized water.
Further, the rubbing agent can be selected in calcium carbonate, calcium phosphate, silica, calcium monohydrogen phosphate, aluminium hydroxide
It is one or more of；
One or more of the optional glycerine of the moisturizer, sorbierite, propylene glycol, polyethylene glycol-400；
One or both of the optional sodium carboxymethylcellulose of thickener (CMC), silica；
One or both of the optional xanthans of the adhesive, carragheen；
Lauryl sodium sulfate (K can be selected in the foaming agent12Powder), one or both of sodium lauroyl sarcosine；
One or more of saccharin sodium, glycerine, xylitol can be selected in the sweetener；
The preservative is methyl hydroxybenzoate.
A kind of toothpaste containing bamboo-leaves flavones, based on mass fraction, including：Bamboo-leaves flavones 1-10%, green-tea extract 1-
4%, Cortex Ilicis Rotundae extract 0.1-1.0%, mulberry-leaf extract 0.5-1.5%, calcium carbonate 10-30%, glycerine 5-10%, PEG-
400 1-5%, sorbierite 1-5%, CMC0.1-1.0%, silica 1-8%, xanthans 9270 0.1-1.0%, K12Powder 1-
4%, saccharin sodium 0.1-0.5%, methyl hydroxybenzoate 0.05-0.3%, essence 1-2%, light green pigment 0.01-0.05% and deionization
Water surplus.
Further, the toothpaste containing bamboo-leaves flavones, based on mass fraction, including：Bamboo-leaves flavones 3%, green-tea extract
2%, Cortex Ilicis Rotundae extract 0.3%, mulberry-leaf extract 1%, calcium carbonate 30%, glycerine 10%, PEG-400 5%, sorbierite
5%, CMC 0.6%, silica 4%, xanthans 9,270 0.65%, K12Powder 2.3%, saccharin sodium 0.25%, methyl hydroxybenzoate
0.15%, essence 1%, light green pigment 0.028% and deionized water surplus.
A kind of preparation method of the composition for oral cavity containing bamboo-leaves flavones, includes the following steps：
(1) weighs each raw material by formula ratio；
(2) thickener CMC, adhesive xanthans are added in glycerine and PEG-400 (moisturizer) by, stirring to formation
Finely dispersed suspension；
(3) saccharin sodium is add to deionized water by, and stirring is to being completely dissolved；
(4) solution obtained by sorbierite and step 3 is added in step 2 in gained suspension by, and stirring is uniform to being formed
Rubber cement；
(5) methyl hydroxybenzoate is dissolved in essence by；
(6) calcium carbonate, silica are added in (4) in rubber cement by, and cream is made in 15 minutes in 3000 turns of stirrings of mixing speed
Body；
(7) is by bamboo-leaves flavones, mixed extract, the K of four kinds of green-tea extract, iron holly bark and mulberry-leaf extract Chinese medicine12
Powder, light green pigment and toothpaste matrix are mixed evenly, by vacuum outgas, it is filling, seal to obtain the final product.
" stirring " operation in the step 1-7, mixing speed is 500rpm, mixing time 20-40min.
Advantageous effect of the present invention：
The composition for oral cavity lotion containing bamboo-leaves flavones of the present invention is fine and smooth, pure and fresh tasty and refreshing.
The present invention adds in bamboo-leaves flavones to composition, as toothpaste multifunction additive, has gentle flavor and mouth
Sense, no flavour of a drug, bitter taste and penetrating odor, good water solubility, stay in grade can effectively resist acidolysis, pyrolysis and enzymolysis, be suitable for
Toothpaste system.Its multifunctionality is embodied in：Other than efficient lipid peroxidation inhibition or a kind of natural uranidin, have both
Antibacterial, antibacterial, deodorization, the effect of flavouring.
Specific implementation mode
In order to better illustrate technical solution of the present invention problem to be solved, the technical solution of use and reach beneficial
Effect is expanded on further in conjunction with specific implementation mode.It is worth noting that technical solution of the present invention is including but not limited to following
Embodiment.
Particular technique or condition are not specified in the embodiment of the present invention, according to technology described in document in the art or
Condition is carried out according to product description.Reagents or instruments used without specified manufacturer, being can be by purchased in market etc.
The conventional products that approach obtains.
The toothpaste containing bamboo-leaves flavones of 1 present invention of embodiment
Prepare raw material in proportion：Saccharin sodium 0.25%, glycerine 10%, PEG-400 5%, CMC 0.6%, xanthans
(9270) 0.65%, methyl hydroxybenzoate 0.15%, sorbierite 5%, calcium carbonate 30%, K12Powder 2.3%, silica 4%, the leaf of bamboo are yellow
Ketone 3%, green-tea extract 2%, Cortex Ilicis Rotundae extract 0.3% and mulberry-leaf extract 1%, essence 1%, light green pigment 0.028%
And balance deionized water.
Preparation method：
(1) each raw material is weighed by above-mentioned formula ratio；
(2) adhesive C MC, xanthans are added in glycerine and PEG-400 (wetting agent), stirring to formation is uniformly dispersed
Suspension；
(3) saccharin sodium is add to deionized water, stirring is to being completely dissolved；
(4) solution obtained by sorbierite and step 3 is added in step 2 in gained suspension, stirring is uniform to being formed
Rubber cement；
(5) methyl hydroxybenzoate is dissolved in essence；
(6) calcium carbonate, silica are added in (4) in rubber cement, cream is made in 15 minutes in 3000 turns of stirrings of mixing speed
Body；
(7) by bamboo-leaves flavones, mixed extract, the K of four kinds of green-tea extract, iron holly bark and mulberry-leaf extract Chinese medicine12Powder,
Light green pigment is mixed evenly with toothpaste matrix, by vacuum outgas, it is filling, seal to obtain the final product.
The toothpaste containing bamboo-leaves flavones of 2 present invention of embodiment
Saccharin sodium 0.5%, glycerine 5%, PEG-400 1%, CMC (adhesive) 0.1%, xanthans (9270) 1%, oxybenzene
Methyl esters 0.3%, sorbierite 1%, calcium carbonate 10%, K12Powder 1.0%, silica 8%, bamboo-leaves flavones 10%, green-tea extract
4%, Cortex Ilicis Rotundae extract 0.1% and mulberry-leaf extract 0.5%, essence 2%, light green pigment 0.01% and deionized water surplus.
The preparation method is the same as that of Example 1.
The toothpaste containing bamboo-leaves flavones of 3 present invention of embodiment
Saccharin sodium 0.25%, glycerine 10%, PEG-400 5%, CMC 0.6%, xanthans (9270) 0.65%, oxybenzene first
Ester 0.15%, sorbierite 5%, calcium carbonate 30%, K12Powder 2.3%, silica 4%, bamboo-leaves flavones 2%, green-tea extract
1%, Cortex Ilicis Rotundae extract 0.2% and mulberry-leaf extract 0.5%, essence 1%, light green pigment 0.028% and balance deionized water.
The preparation method is the same as that of Example 1.
Embodiment 4 is free of the toothpaste of bamboo-leaves flavones
Saccharin sodium 0.25%, glycerine 10%, PEG-400 5%, CMC 0.6%, xanthans (9270) 0.65%, oxybenzene first
Ester 0.15%, sorbierite 5%, calcium carbonate 30%, K12Powder 2.3%, silica 4%, green-tea extract 2%, iron holly bark extraction
Object 0.3% and mulberry-leaf extract 1%, essence 1%, light green pigment 0.028% and balance deionized water.
The preparation method is the same as that of Example 1.
Comparative example 1
Formula and each component dosage are each dosage component one in being directly formulated difference lies in this comparative example with embodiment 1
The mixture that secondary property is directly mixed to get.
The toothpaste containing bamboo-leaves flavones of 5 present invention of embodiment
Saccharin sodium 0.1%, glycerine 7%, PEG-400 3%, CMC (adhesive) 1%, xanthans (9270) 0.1%, oxybenzene
Methyl esters 0.05%, sorbierite 2.8%, calcium carbonate 19%, K12Powder 4%, silica 1 %, bamboo-leaves flavones 1%, green-tea extract
1%, Cortex Ilicis Rotundae extract 1% and mulberry-leaf extract 1.5%, essence 1.3%, light green pigment 0.05% and deionized water surplus.
The preparation method is the same as that of Example 1.
Zoopery example 1
Anti-inflammatory effect
Healthy male Kun Ming mice 70,18~22g of weight is taken, it is random to divide equally 7 groups, every group 10.When experiment, respectively
0.1ml caused by dimethylbenzene xylene inflammation is uniformly smeared on two sides inside and outside every animal auris dextra exterior feature of group, and left ear is untreated to make self-blank control.It applies
After smearing dimethylbenzene 30min, each group tested material sample 0.1g is uniformly smeared on two sides respectively inside and outside every animal auris dextra exterior feature of each group.Administration
After 1h, mouse cervical dislocation is put to death, and cuts two auricles, auris dextra exterior feature tested material sample is washed away with physiological saline, and dry cotton ball is cleaned, weight
Folded two auricles take two circle auricles in same position chisel with the card punch of internal diameter 8mm, weigh on electronic analytical balance respectively, right
It is swelling value that auricle weight, which subtracts left auricle weight,.It the results are shown in Table 1.
The influence (X ± SD) of 1 sample paraxylene induced mice auricle acute inflammation swelling of table
| Group | Dosage (g/ is only) | Auricle edema value (mg) |
| Blank control group | 0.1 | 19.31±7.52 |
| Toothpaste bare substrate group | 0.1 | 17.15±8.39 |
| 1 toothpaste group of embodiment | 0.1 | 10.17±6.83**## |
| 3 toothpaste group of embodiment | 0.1 | 13.02±6.94*# |
| 4 toothpaste group of embodiment | 0.1 | 13.93±9.16*# |
| 1 mixture of comparative example | 0.1 | 13.58±6.24*# |
| Contrast groups (commercially available inflammation-diminishing toothpaste) | 0.1 | 12.86±8.91*# |
Bacteriostatic test
Utilize disk diffusion method：There is the bacteria suspension of streptococcus mutans to be applied to the brain heart with oese picking uniform crossover cultivation
On infusion agar culture medium, totally 6.There is the bacteria suspension of Candida albicans to be applied to Sharpe with oese picking uniform crossover cultivation
On glucose agar medium, totally 6.Toothpaste about 50mg is spread evenly across on the roundlet filter paper of a diameter of 6mm respectively, each
6, toothpaste.A kind of roundlet filter paper of toothpaste will be coated with and be divided into two groups, every group is attached on culture medium symmetrically respectively
Middle section (each culture medium of each bacterium).Finally culture dish is placed in 37 DEG C of constant temperature incubator and observes knot afterwards for 24 hours
Fruit measures antibacterial circle diameter.3 repeated experiments, using 3 average values as bacteriostatic diameter.It the results are shown in Table 2.
The bacteriostatic test of 2 toothpaste of table
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (9)
1. a kind of composition for oral cavity containing bamboo-leaves flavones, which is characterized in that including：
Bamboo-leaves flavones 1-10%, green-tea extract 1-4%, Cortex Ilicis Rotundae extract 0.1-1.0% and mulberry-leaf extract 0.5-
1.5%.
2. the composition for oral cavity according to claim 1 containing bamboo-leaves flavones, which is characterized in that the bamboo-leaves flavones, green
Ratio is when tea extraction, Cortex Ilicis Rotundae extract and mulberry-leaf extract are combined：3：2：0.3：1.
3. the composition for oral cavity according to claim 1 containing bamboo-leaves flavones, which is characterized in that the bamboo-leaves flavones purity
Not less than 40%.
4. the composition for oral cavity according to claim 1 containing bamboo-leaves flavones, which is characterized in that the green-tea extract is pure
Degree is not less than 98%；The Cortex Ilicis Rotundae extract derives from the bark or root skin of holly plant ilexrotunda；The mulberry leaf extraction
Object purity is not less than 40%.
5. the composition for oral cavity containing bamboo-leaves flavones according to any one of claims 1-4, which is characterized in that described to contain
The composition for oral cavity of bamboo-leaves flavones can be used for preparing paste, liquid or spray form oral care product.
6. a kind of toothpaste containing bamboo-leaves flavones, which is characterized in that based on mass fraction, including：Bamboo-leaves flavones 1-10%, green tea carry
Take object 1-4%, Cortex Ilicis Rotundae extract 0.1-1.0%, mulberry-leaf extract 0.5-1.5%, rubbing agent 1%-30%, moisturizer 1%-
20%, thickener 0.3%-15%, adhesive 0.1%-2.5%, foaming agent 0.4%-4%, sweetener 0.01%-1%, anti-corrosion
Agent 0.05-0.5%, essence 1-2%, light green pigment 0.01-0.05%, surplus is deionized water.
7. the toothpaste according to claim 6 containing bamboo-leaves flavones, which is characterized in that based on mass fraction, including：The leaf of bamboo is yellow
Ketone 1-10%, green-tea extract 1-4%, Cortex Ilicis Rotundae extract 0.1-1.0%, mulberry-leaf extract 0.5-1.5%, calcium carbonate 10-
30%, glycerine 5-10%, PEG-400 1-5%, sorbierite 1-5%, CMC 0.1-1.0%, silica 1-8%, xanthans
9270 0.1-1.0%, K12Powder 1-4%, saccharin sodium 0.1-0.5%, methyl hydroxybenzoate 0.05-0.3%, essence 1-2%, fruit green
Plain 0.01-0.05% and deionized water surplus.
8. the toothpaste according to claim 7 containing bamboo-leaves flavones, which is characterized in that based on mass fraction, including：The leaf of bamboo is yellow
Ketone 3%, green-tea extract 2%, Cortex Ilicis Rotundae extract 0.3%, mulberry-leaf extract 1%, calcium carbonate 30%, glycerine 10%, PEG-
400 5%, sorbierite 5%, CMC 0.6%, silica 4%, xanthans 9,270 0.65%, K12Powder 2.3%, saccharin sodium
0.25%, methyl hydroxybenzoate 0.15%, essence 1%, light green pigment 0.028% and deionized water surplus.
9. the preparation method of the toothpaste containing bamboo-leaves flavones described in claim 6-8, which is characterized in that include the following steps：
(1) weighs each raw material by formula ratio；
(2) thickener CMC, adhesive xanthans are added in glycerine and PEG-400 (moisturizer) by, stirring to formation dispersion
Uniform suspension；
(3) saccharin sodium is add to deionized water by, and stirring is to being completely dissolved；
(4) solution obtained by sorbierite and step 3 is added in step 2 in gained suspension by, and stirring is to forming equal spin coating
Slurry；
(5) methyl hydroxybenzoate is dissolved in essence by；
(6) calcium carbonate, silica are added in (4) in rubber cement by, and lotion is made in 15 minutes in 3000 turns of stirrings of mixing speed；
(7) is by bamboo-leaves flavones, mixed extract, the K of four kinds of green-tea extract, iron holly bark and mulberry-leaf extract Chinese medicine12Powder, fruit
Marennin is mixed evenly with toothpaste matrix, by vacuum outgas, it is filling, seal to obtain the final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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