CN108743805A - A kind of Chinese medicine composition and preparation method thereof for treating reflux gastritis, esophagitis and epithelial metaplasia - Google Patents

A kind of Chinese medicine composition and preparation method thereof for treating reflux gastritis, esophagitis and epithelial metaplasia Download PDF

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CN108743805A
CN108743805A CN201810946775.6A CN201810946775A CN108743805A CN 108743805 A CN108743805 A CN 108743805A CN 201810946775 A CN201810946775 A CN 201810946775A CN 108743805 A CN108743805 A CN 108743805A
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熊学荣
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/12Magnesium silicate
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/75Rutaceae (Rue family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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Abstract

The invention discloses a kind of Chinese medicine compositions for treating reflux gastritis, esophagitis and epithelial metaplasia, which is characterized in that including 8-12 pieces of 5-7g mixing Chinese medicine and jujube, wherein the raw material for mixing Chinese medicine includes by weight:27-33 parts of RHIZOMA COPTIDIS from Sichuan of China, 27-33 parts of licorice, 55-65 parts of Fructus Aurantii, 55-65 parts of dried orange peel, 145-155 parts of talcum, rice fry 95-105 parts of sky dragon, 95-105 parts of Radix Notoginseng, 95-105 parts of the bletilla striata.The invention also discloses the preparation methods of the Chinese medicine composition of above-mentioned treatment reflux gastritis, esophagitis and epithelial metaplasia.The present invention, which treats reflux gastritis, esophagitis and epithelial metaplasia, has good effect.

Description

A kind of Chinese medicine composition that treating reflux gastritis, esophagitis and epithelial metaplasia and its Preparation method
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of reflux gastritis, esophagitis and epithelial metaplasias for the treatment of Chinese medicine composition and preparation method thereof.
Background technology
Reflux gastritis, esophagitis are formed as musculus sphincter pyloricus relaxation, cause content reflux to oesophagus, because Intestinal contents contain bile, after reflux to stomach and oesophagus, cause stomach and Esophageal Mucosa impaired, obstinate, Relapse rate, eventually Form epithelial metaplasia and canceration.Often it is treated by Western medicine at present, but is easy repeatedly.
Invention content
Technical problems based on background technology, the present invention propose it is a kind of treat reflux gastritis, esophagitis and on The Chinese medicine composition and preparation method thereof of skin metaplasia, the present invention, which treats reflux gastritis, esophagitis and epithelial metaplasia, to be had well Effect.
A kind of Chinese medicine composition for treating reflux gastritis, esophagitis and epithelial metaplasia proposed by the present invention, including 5-7g Mix 8-12 pieces of Chinese medicine and jujube, wherein the raw material for mixing Chinese medicine includes by weight:27-33 parts of RHIZOMA COPTIDIS from Sichuan of China, licorice 27- 33 parts, 55-65 parts of Fructus Aurantii, 55-65 parts of dried orange peel, 145-155 parts of talcum, rice 95-105 parts of sky dragon of stir-fry, 95-105 parts of Radix Notoginseng, the bletilla striata 95-105 parts.
RHIZOMA COPTIDIS from Sichuan of China, alias are the coptis, river company, Jiang Lian, prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice, RHIZOMA COPTIDIS from Sichuan of China etc., are the ranunculaceae plant coptis, triangle leaf Huang The dry rhizome of company or cloud even.Bitter, it is cold in nature;Return stomach, the heart, liver, large intestine channel.Energy purging intense heat, eliminating dampness, removing toxic substances, desinsection.Row heat when controlling Poison, typhoid fever, excess heat is vexed, and feeling of fullness is vomitted inverse, bacillary dysentery, and heat rushes down abdominal pain, and lung knot is pressed, and is spat, is defeated in battle, lower blood, quenching one's thirst, infantile malnutrition due to digestive disturbances or intestinalparasites, roundworm disease, and hundred Day cough, abscess of throat, pinkeye, aphtha, skin sore, eczema, the burning hot wound of soup.
Licorice, alias is Herba Hedyotis cantonensis root, Radix Glycyrrhizae, unpeeled RADIX GLYCYRRHIZAE, powder grass, lantern, the sweet, honeywort of honey, Lu is careless, state is old, it is well-informed, Herba Hedyotis cantonensis, sweet tea root, stick grass etc., for dicotyledon pulse family Radix Glycyrrhizae, the root and rhizome of swollen fruit Radix or glycyrrhiza glabra.It is sweet in flavor, property It is flat, return stomach, lung, the spleen channel.Can be clearing heat and detoxicating, it moistens the lung and relieve the cough, coordinating the drug actions of a prescription;Honey-fried licorice root can invigorate the spleen and benefit qi.Cure mainly abscess of throat, cough It coughs, weakness of the spleen and the stomach, taste-blindness rate, hepatitis, hysteria, carbuncle furuncle poison, drug and food poisoning.
Fructus Aurantii is rutaceae bitter orange, citron, bitter orange flower or the last ripening fruits of trifoliate orange.Bitter, pungent, sour, property is micro- It is cold.Return lung, spleen, large intestine channel.Energy regulating the flow of QI to ease the stomach, the stagnant disperse accumulation of row.Cure mainly chest side of body feeling of fullness distending pain, accumulation of food in the stomach and intes tine due to indigestion, abdominal distention, vomiting Hiccup, weight, hematochezia after hot dysentery;Gastroptosis, the prolapse of uterus, rectal prolapse.
Dried orange peel, alias are orange peel, expensive old, red skin, yellow orange peel, wide orange peel, PERICARPIUM CITRI RETICULATAE, orange peel, citrus chachiensis hortorum etc., are Rutaceae Plant tangerine and its dry pericarp of the maturation of variety.Acrid flavour, hardship, warm-natured, return lung, the spleen channel.Energy regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm. For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Talcum, alias is picture stone, liquid stone, stone, de- stone, kind stone, sunset be cold altogether, crisp stone, stays stone, stone living etc., is silicates Mineral talc talc;It except impurity elimination stone, cleans, pounds into fragment, be ground into fine powder, or shine elutriation fine grinding, dry obtained.Taste It is sweet, light, it is cold in nature, return stomach, bladder warp, energy heat-clearing, excreting dampness, sharp key.Control hot summer weather polydipsia, difficult urination, watery diarrhea, hot dysentery, gonorrhoea, Huang Subcutaneous ulcer, oedema, bleeding from five sense organs or subcutaneous tissue, tinea pedis, skin moisture fester.
Sky dragon, alias are centipede, centipede, thousand-legger, golden head centipede, centipede, Ji maggots, Wu Gong, sky dragon, the high nurse of ouch etc.. Taste is salty, pungent, warm-natured, Return liver, spleen, lung channel, and poison, dissipating bind are attacked in energy wind-dispelling, arresting convulsion.Control apoplexy, frightened epilepsy, lockjaw, pertussis, scrofula Scrofula, tuberculosis, disease buildup block, sore swollen toxin, wind tinea, white bald, anal fistula, scald.Rice fry sky dragon be with rice frying sky dragon to it is sallow i.e. It can.
Radix Notoginseng, alias are pseudo-ginseng, Yunnan seven, radix notoginseng, Radix Notoginseng, mountain paint, invaluable, blood ginseng, Typhonium flagelliforme (Lodd.) Blume etc., are Araliaceae The root of plant Radix Notoginseng.It is sweet in flavor, bitter, it is warm-natured, return stomach, Liver Channel, energy dissipate stasis of blood hemostasis, detumescence ding-tong.For spitting blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, just Blood, uterine bleeding, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
The bletilla striata, alias are bletilla, Bai Gen, Pseudobulbus Bletillae (Rhizoma Bletillae), Cold boiled chicken, Cold boiled chicken baby, Lian Jicao, horn seven etc., are orchid The dry tuber of bletilla.It is sweet in flavor, bitter, cool in nature, distributed in lung channel, energy astringing to arrest bleeding, detumescence and promoting granulation.It spits blood for hemoptysis, traumatic hemorrhage, Sore swollen toxin, chapped skin;Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.
Jujube is the dry mature fruit of Rhamnaceae jujube jujube.It is sweet in flavor, it is warm-natured.Return stomach, the spleen channel.Energy tonifying spleen and stomach, Nourishing generate fluid adjusts battalion to defend, antidote poison.Stomach void deficiency of food is controlled, the weak loose stool of spleen, qi-blood-body fluid is insufficient, disharmony between ying and wei, palpitation and severe palpitation, woman People's stolen goods are hot-tempered.
Preferably, including 9-11 pieces of 5.5-6.5g mixing Chinese medicine and jujube.
Preferably, including 10 pieces of 6g mixing Chinese medicine and jujube.
Preferably, RHIZOMA COPTIDIS from Sichuan of China, licorice, Fructus Aurantii, dried orange peel weight ratio be 28-32:28-32:58-62:58-62.
Preferably, talcum, rice fry sky dragon, Radix Notoginseng, the bletilla striata weight ratio be 148-152:98-102:98-102:98-102.
Preferably, the raw material for mixing Chinese medicine includes by weight:28-32 parts of RHIZOMA COPTIDIS from Sichuan of China, 28-32 parts of licorice, Fructus Aurantii 58- 62 parts, 58-62 parts of dried orange peel, 148-152 parts of talcum, rice 98-102 parts of sky dragon of stir-fry, 98-102 parts of Radix Notoginseng, 98-102 parts of the bletilla striata.
Preferably, the raw material for mixing Chinese medicine includes by weight:30 parts of RHIZOMA COPTIDIS from Sichuan of China, 30 parts of licorice, 60 parts of Fructus Aurantii, dried orange peel 60 parts, 150 parts of talcum, rice fries 100 parts of sky dragon, 100 parts of Radix Notoginseng, 100 parts of the bletilla striata.
The invention also provides the preparation sides of the Chinese medicine composition of above-mentioned treatment reflux gastritis, esophagitis and epithelial metaplasia Method includes the following steps:It is stewed with jujube plus water, is added in soup after each raw material mixing for mixing Chinese medicine is pulverized to obtain the final product.
Above-mentioned " being stewed with jujube plus water ", does not provide the dosage of water, its dosage is determined according to concrete operations.
The present invention application method be:The present invention is ampoule, three times a day, is taken in 1 hour before meals, 2 months It is as a treatment course.
Advantageous effect:
The coptis is bitter, cold in the present invention, energy heat clearing and inflammation relieving, and drop is inverse to remove ruffian;Jujube tonifying spleen nourishing the stomach, Radix Glycyrrhizae can be anti-inflammatory and be resistant to Ulcer, gastric acid secretion inhibiting;Dried orange peel, Fructus Aurantii regulating qi-flowing for harmonizing stomach, eliminating phlegm and lowering adverse QI;Talcum is sweet, light, and can disappear cremate phlegm, dampness removing;Radix Notoginseng lives Blood stagnation resolvation, bletilla striata astringing to arrest bleeding, detumescence ding-tong;Sky dragon dissipates solution removing toxic substances, and rice specially enters stomach after frying, and can reach to alimentary canal has cancer energy It controls, the effect that no cancer can prevent;Clinical treatment reflux gastritis, esophagitis 85, reflux gastritis, esophagitis with esophageal squamous and Glandular epithelium metaplasia 17 is all cured after a course of therapy.
Specific implementation mode
In the following, technical scheme of the present invention is described in detail by specific embodiment.
Embodiment 1
A kind of Chinese medicine composition for treating reflux gastritis, esophagitis and epithelial metaplasia, including 5g mixing Chinese medicine and jujube 12 pieces, wherein the raw material for mixing Chinese medicine includes by weight:27 parts of RHIZOMA COPTIDIS from Sichuan of China, 33 parts of licorice, 55 parts of Fructus Aurantii, 65 parts of dried orange peel, 145 parts of talcum, rice fry 105 parts of sky dragon, 95 parts of Radix Notoginseng, 105 parts of the bletilla striata.
The preparation method of the Chinese medicine composition of above-mentioned treatment reflux gastritis, esophagitis and epithelial metaplasia, including walk as follows Suddenly:It is stewed with jujube plus water, is added in soup after each raw material mixing for mixing Chinese medicine is pulverized to obtain the final product.
Embodiment 2
A kind of Chinese medicine composition for treating reflux gastritis, esophagitis and epithelial metaplasia, including 7g mixing Chinese medicine and jujube 8 Piece, wherein the raw material for mixing Chinese medicine includes by weight:33 parts of RHIZOMA COPTIDIS from Sichuan of China, 27 parts of licorice, 65 parts of Fructus Aurantii, 55 parts of dried orange peel are sliding 155 parts of stone, rice fry 95 parts of sky dragon, 105 parts of Radix Notoginseng, 95 parts of the bletilla striata.
The preparation method of the Chinese medicine composition of above-mentioned treatment reflux gastritis, esophagitis and epithelial metaplasia, including walk as follows Suddenly:It is stewed with jujube plus water, is added in soup after each raw material mixing for mixing Chinese medicine is pulverized to obtain the final product.
Embodiment 3
A kind of Chinese medicine composition for treating reflux gastritis, esophagitis and epithelial metaplasia, including 5.5g mixing Chinese medicine and red 11 pieces of jujube, wherein the raw material for mixing Chinese medicine includes by weight:28 parts of RHIZOMA COPTIDIS from Sichuan of China, 32 parts of licorice, 58 parts of Fructus Aurantii, dried orange peel 62 Part, 148 parts of talcum, rice fries 102 parts of sky dragon, 98 parts of Radix Notoginseng, 102 parts of the bletilla striata.
The preparation method of the Chinese medicine composition of above-mentioned treatment reflux gastritis, esophagitis and epithelial metaplasia, including walk as follows Suddenly:It is stewed with jujube plus water, is added in soup after each raw material mixing for mixing Chinese medicine is pulverized to obtain the final product.
Embodiment 4
A kind of Chinese medicine composition for treating reflux gastritis, esophagitis and epithelial metaplasia, including 6.5g mixing Chinese medicine and red 9 pieces of jujube, wherein the raw material for mixing Chinese medicine includes by weight:32 parts of RHIZOMA COPTIDIS from Sichuan of China, 28 parts of licorice, 62 parts of Fructus Aurantii, dried orange peel 58 Part, 152 parts of talcum, rice fries 98 parts of sky dragon, 102 parts of Radix Notoginseng, 98 parts of the bletilla striata.
The preparation method of the Chinese medicine composition of above-mentioned treatment reflux gastritis, esophagitis and epithelial metaplasia, including walk as follows Suddenly:It is stewed with jujube plus water, is added in soup after each raw material mixing for mixing Chinese medicine is pulverized to obtain the final product.
Embodiment 5
A kind of Chinese medicine composition for treating reflux gastritis, esophagitis and epithelial metaplasia, including 6g mixing Chinese medicine and jujube 10 pieces, wherein the raw material for mixing Chinese medicine includes by weight:30 parts of RHIZOMA COPTIDIS from Sichuan of China, 30 parts of licorice, 60 parts of Fructus Aurantii, 60 parts of dried orange peel, 150 parts of talcum, rice fry 100 parts of sky dragon, 100 parts of Radix Notoginseng, 100 parts of the bletilla striata.
The preparation method of the Chinese medicine composition of above-mentioned treatment reflux gastritis, esophagitis and epithelial metaplasia, including walk as follows Suddenly:It is stewed with jujube plus water, is added in soup after each raw material mixing for mixing Chinese medicine is pulverized to obtain the final product.
Test example 1
Reflux gastritis, esophagitis 85 are treated with embodiment 5, reflux gastritis, esophagitis are with esophageal squamous and gland shape Epithelial metaplasia 17 is all cured after a course of therapy.
Wherein, during treatment, it is desirable that patient pays attention to following four:1. the food of high protein high in fat is eaten less;2. having enough After not bend over (i.e. head cannot be below waist);3. supper could sleep after 2 hours;4. during sleep, pillow raises 30cm (i.e. Keep upper body higher than lower body).
Above four are bile regurgitations in order to prevent.It is noted that six months time, is that stomach pylorus peristaltic function is extensive by treatment It is multiple normal.
Medical record is illustrated:
Yue Changjiang, man, 69 years old, showed cardia inflammation, chronic non-atrophic gastritis accompanied courage in gastrocopy on December 16 in 2017 Juice reflux, hyperplasia of squamous epithelium is with parakeratosis (precancerous lesion) at esophagus 37cm;May 8 in 2018 after being treated with embodiment 5 Day gastroscope check, hyperplasia of squamous epithelium disappear with parakeratosis, and stomach functional rehabilitation is normal.
Present invention treatment treatment reflux gastritis, esophagitis and epithelial metaplasia have good it can be seen from result above Effect.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (8)

1. a kind of Chinese medicine composition for treating reflux gastritis, esophagitis and epithelial metaplasia, which is characterized in that mixed including 5-7g 8-12 pieces of Chinese medicine and jujube, wherein the raw material for mixing Chinese medicine includes by weight:27-33 parts of RHIZOMA COPTIDIS from Sichuan of China, 27-33 parts of licorice, 55-65 parts of Fructus Aurantii, 55-65 parts of dried orange peel, 145-155 parts of talcum, rice fry 95-105 parts of sky dragon, 95-105 parts of Radix Notoginseng, bletilla striata 95- 105 parts.
2. treat according to claim 1 reflux gastritis, esophagitis and epithelial metaplasia Chinese medicine composition, feature exists In, including 9-11 pieces of 5.5-6.5g mixing Chinese medicine and jujube.
3. the Chinese medicine composition for the treatment of reflux gastritis according to claim 1 or claim 2, esophagitis and epithelial metaplasia, feature It is, including 10 pieces of 6g mixing Chinese medicine and jujube.
4. according to any one of the claim 1-3 treatment reflux gastritis, the Chinese medicine composition of esophagitis and epithelial metaplasia, Be characterized in that, RHIZOMA COPTIDIS from Sichuan of China, licorice, Fructus Aurantii, dried orange peel weight ratio be 28-32:28-32:58-62:58-62.
5. according to any one of the claim 1-4 treatment reflux gastritis, the Chinese medicine composition of esophagitis and epithelial metaplasia, Be characterized in that, talcum, rice fry sky dragon, Radix Notoginseng, the bletilla striata weight ratio be 148-152:98-102:98-102:98-102.
6. according to any one of the claim 1-5 treatment reflux gastritis, the Chinese medicine composition of esophagitis and epithelial metaplasia, It is characterized in that, the raw material for mixing Chinese medicine includes by weight:28-32 parts of RHIZOMA COPTIDIS from Sichuan of China, 28-32 parts of licorice, 58-62 parts of Fructus Aurantii, 58-62 parts of dried orange peel, 148-152 parts of talcum, rice fry 98-102 parts of sky dragon, 98-102 parts of Radix Notoginseng, 98-102 parts of the bletilla striata.
7. according to any one of the claim 1-6 treatment reflux gastritis, the Chinese medicine composition of esophagitis and epithelial metaplasia, It is characterized in that, the raw material for mixing Chinese medicine includes by weight:30 parts of RHIZOMA COPTIDIS from Sichuan of China, 30 parts of licorice, 60 parts of Fructus Aurantii, 60 parts of dried orange peel, 150 parts of talcum, rice fry 100 parts of sky dragon, 100 parts of Radix Notoginseng, 100 parts of the bletilla striata.
8. the Chinese medicine composition of a kind for the treatment of reflux gastritis as described in claim any one of 1-7, esophagitis and epithelial metaplasia Preparation method, which is characterized in that include the following steps:It is stewed with jujube plus water, each raw material mixing for mixing Chinese medicine is ground Cheng Fenhou is added in soup to obtain the final product.
CN201810946775.6A 2018-08-20 2018-08-20 A kind of Chinese medicine composition and preparation method thereof for treating reflux gastritis, esophagitis and epithelial metaplasia Pending CN108743805A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110279807A (en) * 2019-07-26 2019-09-27 右江民族医学院 A kind of Chinese medicine composition and preparation method thereof for treating reflux esophagitis

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Publication number Priority date Publication date Assignee Title
CN102793862A (en) * 2011-05-24 2012-11-28 董玺 Formula of Chinese medicine for treating bile reflux gastritis
CN106924539A (en) * 2017-03-23 2017-07-07 湖北工业大学 A kind of Chinese medicine preparation for treating peptic ulcer, gastritis and reflux esophagitis and its preparation method and application

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Publication number Priority date Publication date Assignee Title
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Application publication date: 20181106