CN108743749A - 一种治疗慢性咳嗽的中药组合物及其制备方法和应用 - Google Patents
一种治疗慢性咳嗽的中药组合物及其制备方法和应用 Download PDFInfo
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Abstract
本发明涉及一种治疗慢性咳嗽的中药组合物及其制备方法和应用,该中药组合物由包括如下重量份的原料制成:甘草12‑15份、杏仁6‑10份、苏子6‑10份、蝉蜕6‑10份、僵蚕6‑10份、射干6‑10份、玄参10‑15份、板蓝根10‑15份、冬花6‑10份、紫菀6‑10份、党参10‑20份、陈皮6‑9份、桔梗6‑9份、连翘10‑15份;该中药组合物通过各原料协同作用能够祛风化痰、润肺下气、利咽止咳,对于慢性咳嗽具有治愈率高、疗效快、疗程短、效果显著;此外,对人体无毒副作用。
Description
技术领域
本发明涉及中药技术领域,具体而言,涉及一种治疗慢性咳嗽的中药组合物及其制备方法和应用。
背景技术
咳嗽(cough)是一种呼吸道常见症状,由于气管、支气管黏膜或胸膜受炎症、异物、物理或化学性刺激引起,表现先是声门关闭、呼吸肌收缩、肺内压升高,然后声门张开,肺内空气喷射而出,通常伴随声音。咳嗽具有清除呼吸道异物和分泌物的保护性作用。咳嗽是最为常见及极为普遍的病症之一。它虽然不危及性命,但若持久不愈,便会影响睡眠质量,造成胸闷、气喘与气短等症状。普通咳嗽一般很快痊愈,一旦失治或误治,就会演变成复杂的慢性咳嗽,即变异性咳嗽,常给患者带来很大的痛苦。
中医把咳嗽大致分成两大类,即外感咳嗽与内伤咳嗽。外感咳嗽,病轻浅,只要及时治疗,多能短时间内治愈。内伤咳嗽多呈慢性反复发作过程,病程延续,治疗难取速效。咳嗽的症状千变万化,中医治疗咳嗽,首先以发病时间的长短辨别其属于外感咳嗽或是内伤咳嗽,接着再从痰的量、色、质来确定其寒温性质,之后再依证施治。根据中医整体观念,可以针对不同病因多角度进行治疗,发挥中医辨证施治优势,因而疗效显著,但现有中药治疗时间长,效果差,病情反复,使得患者病程较长,增加了患者痛苦,也使得患者进入更危险的病情期。
有鉴于此,特提出本发明。
发明内容
本发明的第一目的在于提供一种治疗慢性咳嗽的中药组合物,该中药组合物通过各原料协同作用能够祛风化痰、润肺下气、利咽止咳,对于慢性咳嗽具有治愈率高、疗效快、疗程短、效果显著;此外,对人体无毒副作用。
本发明的第二目的在于提供一种治疗慢性咳嗽的中药组合物的制备方法,该方法能够充分的提取各原料中有效成分,提高了所制备的中药组合物的药效。
本发明的第三目的在于提供一种包含上述中药组合物的临床制剂,该临床制剂利于其有效成分的释放和吸收,能够更好的治疗慢性咳嗽,并对人体无毒副作用。
为了实现本发明的上述目的,特采用以下技术方案:
本发明第一方面提供一种治疗慢性咳嗽的中药组合物,该中药组合物由包括如下重量份的原料制成:
甘草12-15份、杏仁6-10份、苏子6-10份、蝉蜕6-10份、僵蚕6-10份、射干6-10份、玄参10-15份、板蓝根10-15份、冬花6-10份、紫菀6-10份、党参10-20份、陈皮6-9份、桔梗6-9份、连翘10-15份。
本发明基于中医整体观念,发挥中医辨证施治优势,针对不同病因多角度进行治疗,虚实结合、标本兼治,筛选具有祛风化痰、润肺下气、利咽止咳、清热解毒等天然药物,根据中医理论,按照特定的重量份配比制备而成,该中药组合物对于慢性咳嗽具有治愈率高、疗效快、疗程短、效果显著;此外,对人体无毒副作用。
本发明中采用的各中药原料如下:
甘草:性平、味甘,归十二经,是一种补益中草药;生甘草能清热解毒,润肺止咳,调和诸药性;炙甘草能补脾益气。
杏仁:性味,苦、微温;归肺经;具有止咳、平喘、怯痰、润肺等功效;用于外感咳嗽、气逆喘满、痰多及肠燥便秘。
苏子:性味,辛、温;归肺经;具有降气消痰、平喘、润肠等功效;用于痰壅气逆、咳嗽气喘、肠燥便秘。
蝉蜕:性味,寒、甘;归肺、肝经;具有疏散风热、宣肺透疹、明目退翳、息风止痉等功效;用于治外感风热、咳嗽音哑、麻疹透发不畅、风疹瘙痒、小儿惊痫、目赤、翳障、疔疮肿毒、破伤风等症。
僵蚕:性味,咸、辛、性平;归肝、肺、胃经;具有息风止痉、祛风止痛、化痰散结的功效;用于肝风夹痰、惊痫抽搐、小儿急惊、破伤风、中风口涡、风热头痛、目赤咽痛、风疹瘙痒、发颐痄腮。
射干:性味,苦、寒;归肺、肝经;具有清热解毒、消痰利咽的功效;用于热毒痰火郁结、咽喉肿痛、痰涎壅盛、咳嗽气喘。
玄参:性味,苦、甘、咸、寒;归肺、胃、肾经;具有清热凉血、降火除烦、解毒散结、滋阴生津;用于治热病伤阴、舌绎烦渴、发斑、骨蒸劳热、夜寐不宁、自汗盗汗、津伤便秘、吐血衄血、咽喉肿痛、痈肿、瘰疬、温毒发斑、目赤、白喉、疮毒。
板蓝根:性味,寒、苦;归心、胃经;具有清热解毒、凉血、利咽;用于温热病发热、头痛、咽痛、斑疹以及痄腮、疮疡、大头瘟等。
紫菀:性味,辛、苦、甘、微温;归肺经;具有润肺下气、化痰止咳等功效;用于咳嗽气喘、劳嗽咳血。
冬花:性味,辛、温;归肺经;具有润肺下气、止咳化痰等功效;用于咳嗽气喘、劳嗽咳血等症。
陈皮:性味,辛、苦、温;归脾、胃、肺经;具有理气和中、燥湿化痰、利水通便等功效;用于脾胃不和、脘腹胀痛、不思饮食、呕吐哕逆、痰湿阻肺、咳嗽痰多、胸膈满闷、头目眩晕、水肿、小便不利、大便秘结、乳痈疮癣、中鱼蟹毒、酒毒。
桔梗:性味辛、苦;归肺经;具有宣肺、利咽、祛痰、排脓等功效;用于咳嗽痰多、胸闷不畅、音哑、肺痈吐脓、疮疡脓成不溃等症。
连翘:性味,苦、微寒;归肺、心、小肠经;具有清热解毒、消肿散结等功效;用于痈疽、瘰疠、乳痈、丹毒、风热感冒、温病初起、温热入营、高热烦渴、神昏发斑、热淋尿闭。
党参:性味,甘、平;归脾、肺经;具有补中益气、生津养血等功效;用于中气不足、食少便溏、咳喘气短、津伤口渴、血虚萎黄、心悸头晕等症。
进一步地,所述中药组合物由包括如下重量份的原料制成:
甘草13-14份、杏仁7-9份、苏子7-9份、蝉蜕7-9份、僵蚕7-9份、射干8-9份、玄参11-14份、板蓝根11-14份、冬花7-8份、紫菀7-8份、党参13-17份、陈皮7-8份、桔梗7-8份、连翘11-14份。
更进一步地,所述中药组合物由包括如下重量份的原料制成:
甘草13份、杏仁8份、苏子8份、蝉蜕9份、僵蚕8份、射干7份、玄参13份、板蓝根12份、冬花8份、紫菀8份、党参15份、陈皮7份、桔梗7份、连翘12份。
本发明的另一方面提供一种上述中药组合物的制备方法,该制备方法,包括如下步骤:
按照重量份称取各原料;
将各原料混匀粉碎、浸泡、煎煮、过滤、浓缩即可。
通过上述制备方法能够充分提取各原料中的有效成分,提高了所制备中药组合物的药效,对治疗慢性咳嗽具有显著疗效。
进一步地,所述浸泡的水添加量为各原料总重量的5-10倍;
优选地,所述浸泡的时间为25-35min。
进一步地,所述破碎是将各原料混匀粉碎至目粒度在200目以上,优选为300-400目。
进一步地,所述煎煮为文火煮沸,并保持15-20min;
优选地,所述浓缩是将过滤后的滤液浓缩至在60℃下,相对密度为1.1-1.2。
通过上述参数的限制,以及对各步骤的具体限定,能够提高各中药原料中有效成分的充分提取,提高所制备中药组合物对慢性咳嗽的治疗效果。
本发明第三方面提供一种中药制剂,该中药制剂包括中药组合物和药学上可接受的辅料,所述中药组合物为上述中药组合物或由上述制备方法制得的中药组合物。
通过将上述中药组合物和药学上常规的辅料制备成中药制剂,能够提高中药制剂中有效成分的释放和吸收,提高治疗慢性咳嗽的效果,缩短疗程,并对人体无毒副作用。
在本发明中对中药制剂的剂型不作严格限制,优选地,所述中药制剂的剂型为颗粒剂、片剂、针剂或汤剂。
本发明另一方面提供一种治疗慢性咳嗽的片剂,该治疗慢性咳嗽的片剂包括上述中药组合物或由上述制备方法制得的中药组合物,以及30-40份的辅料。
优选地,所述辅料选自可溶性淀粉、糖粉和微晶纤维素中的任意一种或多种。
与现有技术相比,本发明的有益效果至少包括:
(1)本发明基于中医整体观念,发挥中医辨证施治优势,针对不同病因多角度进行治疗,虚实结合、标本兼治,筛选具有祛风化痰、润肺下气、利咽止咳、清热解毒等天然药物,根据中医理论,以及各原料有效成分的理化性质和药理活性按照特定的重量份配比制备而成,该中药组合物对于慢性咳嗽具有治愈率高、疗效快、疗程短、效果显著;此外,对人体无毒副作用
(2)本发明中药组合物的制备方法能够充分的提取各原料中有效成分,提高了所制备的中药组合物的药效。
(3)本发明所述临床制剂利于其有效成分的释放和吸收,能够更好的治疗慢性咳嗽,并对人体无毒副作用。
具体实施方式
下面将结合实施例对本发明的实施方案进行详细描述,但是本领域技术人员将会理解,下列实施例仅用于说明本发明,而不应视为限制本发明的范围。实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者,均为可以通过市购买获得的常规产品。
实施例1
一、治疗慢性咳嗽的中药组合物
上述中药组合物由如下重量份的原料制成:
甘草12g、杏仁10g、苏子6g、蝉蜕10g、僵蚕10g、射干6g、玄参10g、板蓝根15g、冬花6g、紫菀6g、党参20g、陈皮9g、桔梗6g、连翘10g;
二、制备方法
按照重量份称取各原料;
将各原料混匀粉碎至300目以上,向粉碎后的原料浸泡在1.3Kg水中25min,随后采用文火煮沸并保持15min,进行过滤收集滤液,并将滤液浓缩至在60℃下,相对密度为1.13。
实施例2
一、治疗慢性咳嗽的中药组合物
上述中药组合物由如下重量份的原料制成:
甘草15g、杏仁6g、苏子10g、蝉蜕6g、僵蚕6g、射干10g、玄参10g、板蓝根10g、冬花10g、紫菀10g、党参10g、陈皮6g、桔梗9g、连翘15g;
二、制备方法
按照重量份称取各原料;
将各原料混匀粉碎至200目以上,向粉碎后的原料浸泡在680g水中35min,随后采用文火煮沸并保持20min,进行过滤收集滤液,并将滤液浓缩至在60℃下,相对密度为1.19。
实施例3
一、治疗慢性咳嗽的中药组合物
上述中药组合物由如下重量份的原料制成:
甘草13g、杏仁8g、苏子8g、蝉蜕9g、僵蚕8g、射干7g、玄参13g、板蓝根12g、冬花8g、紫菀8g、党参15g、陈皮7g、桔梗7g、连翘12g;
二、制备方法
按照重量份称取各原料;
将各原料混匀粉碎至300-400目,向粉碎后的原料浸泡在800g水中30min,随后采用文火煮沸并保持20min,进行过滤收集滤液,并将滤液浓缩至在60℃下,相对密度为1.15。
实施例4
一、治疗慢性咳嗽的片剂
上述片剂的原料配方组成为:
甘草13g、杏仁9g、苏子7g、蝉蜕9g、僵蚕9g、射干8g、玄参11g、板蓝根14g、冬花7g、紫菀8g、党参17g、陈皮7g、桔梗7g、连翘11g;
二、制备方法
将各原料混匀粉碎至300-400目,向粉碎后的原料浸泡在900g水中25min,采用文火煮沸并保持20min,进行过滤收集滤液,并将滤液浓缩至在60℃时,相对密度为1.1,将浓缩液进行干燥,随后添加30g的可溶性淀粉,制成片剂、干燥。
实施例5
一、治疗慢性咳嗽的片剂
上述片剂的原料配方组成为:
甘草14g、杏仁7g、苏子9g、蝉蜕7g、僵蚕7g、射干9g、玄参14g、板蓝根11g、冬花8g、紫菀7g、党参13g、陈皮8g、桔梗8g、连翘14g;
二、制备方法
将各原料混匀粉碎至300-400目,向粉碎后的原料浸泡在1000g水中30min,采用文火煮沸并保持15min,进行过滤收集滤液,并将滤液浓缩至在60℃时,相对密度为1.18,将浓缩液进行干燥,随后添加20g微晶纤维素和20g糖粉,制成片剂、干燥。
对照例1
本对照例为治疗慢性咳嗽的中药组合物,该中药组合物由如下重量份的原料制成:
甘草8g、杏仁8g、苏子8g、蝉蜕15g、僵蚕15g、射干7g、玄参13g、板蓝根12g、冬花8g、紫菀3g、党参15g、陈皮7g、桔梗7g、连翘12g;该中药组合物的制备方法同实施例3。
对照例2
本对照例为治疗慢性咳嗽的中药组合物,该中药组合物由如下重量份的原料制成:
甘草13g、杏仁8g、苏子8g、蝉蜕9g、僵蚕8g、射干3g、玄参5g、板蓝根12g、冬花8g、紫菀8g、党参15g、陈皮7g、桔梗7g、连翘20g;该中药组合物的制备方法同实施例3。
对照例3
本对照例为治疗慢性咳嗽的中药组合物,该中药组合物与实施例3的中药组合物基本相同,区别仅在于将甘草替换成同等份数的蝉蜕。
对照例4
本对照例为治疗慢性咳嗽的中药组合物,该中药组合物与实施例3的中药组合物基本相同,区别仅在于将党参替换成同等份数的甘草。
实验例1
选取150位被确诊慢性咳嗽患者,年龄为5-55岁,随机分为五组,每组30人;
第一组患者服用实施例3的中药组合物;第二组患者服用对照例1的中药组合物;第三组患者服用对照例2的中药组合物;第四组患者服用对照例3的中药组合物;第五组患者服用对照例4的中药组合物。
服用方法:将实施例3和对照例1-4制备得到的中药组合物分别均分为两份,每日早晚各服用一份,持续服用6天,治疗期间停止服用其它治疗药物;
评判标准:
(1)显效:临床症状完全消失,停药半年内不复发;
(2)有效:咳嗽明显减轻、无咳痰、胸闷、气短或临床症状完全消失,但半年内复发;
(3)无效:临床症状无明显改善或加重。
表1各实施例和对照例保健功效检测结果
组别 | 显效(人) | 有效(人) | 无效(人) |
第一组 | 11 | 16 | 3 |
第二组 | 5 | 21 | 4 |
第三组 | 6 | 19 | 5 |
第四组 | 4 | 18 | 8 |
第五组 | 3 | 18 | 9 |
由表1可知:第1-5组中的中药组合物对治疗慢性咳嗽均具有一定疗效,但第1组中中药组合物的治疗效果显著高于第2-5组,可见,当各原料用量在本发明要求保护的范围内时,各中药原料协同效果最好,治疗效果最显著,其有效率达到90%以上。
案例1
李某,女,33岁,咳嗽3月余,期间服用其他药物治疗,停药后反复发作;随后,服用本申请实施例2的中药组合物3个疗程后痊愈(痊愈的评判标准为:咳嗽症状完全消失,且停药半年内无复发),每个疗程为3天,早晚各服用一次,半年后随访,期间无复发。
案例2
张某,男,55岁,常肺部感染治愈后出现慢性咳嗽2年余,咽痒,服用本申请实施例5中药片剂,早晚各服用一次,每次服用4g,服用5个疗程明显改善,续服3个疗程后痊愈(痊愈的评判标准为:咽痒、咳嗽症状完全消失,且停药半年内无复发),随访一年内无复发。
案例3
朱某,男5岁,间断咳嗽1月余;夜间及晨起明显,多方就医无效,服用本实施例4中药片剂3天痊愈(痊愈的评判标准为:咳嗽症状完全消失,且停药半年内无复发),早晚各服用一次,每次服用2g,随访无复发。
最后应说明的是:以上各实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述各实施例对本发明进行了详细的说明,但本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分或者全部技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的范围。
Claims (10)
1.一种治疗慢性咳嗽的中药组合物,其特征在于,由包括如下重量份的原料制成:
甘草12-15份、杏仁6-10份、苏子6-10份、蝉蜕6-10份、僵蚕6-10份、射干6-10份、玄参10-15份、板蓝根10-15份、冬花6-10份、紫菀6-10份、党参10-20份、陈皮6-9份、桔梗6-9份、连翘10-15份。
2.根据权利要求1所述的中药组合物,其特征在于,由包括如下重量份的原料制成:
甘草13-14份、杏仁7-9份、苏子7-9份、蝉蜕7-9份、僵蚕7-9份、射干8-9份、玄参11-14份、板蓝根11-14份、冬花7-8份、紫菀7-8份、党参13-17份、陈皮7-8份、桔梗7-8份、连翘11-14份。
3.根据权利要求1所述的中药组合物,其特征在于,由包括如下重量份的原料制成:
甘草13份、杏仁8份、苏子8份、蝉蜕9份、僵蚕8份、射干7份、玄参13份、板蓝根12份、冬花8份、紫菀8份、党参15份、陈皮7份、桔梗7份、连翘12份。
4.根据权利要求1-3任一所述的中药组合物的制备方法,其特征在于,包括如下步骤:
按照重量份称取各原料;
将各原料混匀粉碎、浸泡、煎煮、过滤、浓缩即可。
5.根据权利要求4所述的制备方法,其特征在于,所述浸泡的水添加量为各原料总重量的5-10倍;
优选地,所述浸泡的时间为25-35min。
6.根据权利要求4所述的制备方法,其特征在于,所述粉碎是将各原料混匀粉碎至目粒度在200目以上,优选为300-400目。
7.根据权利要求4所述的制备方法,其特征在于,所述煎煮为文火煮沸,并保持15-20min;
优选地,所述浓缩是将过滤后的滤液浓缩至在60℃下的相对密度为1.1-1.2。
8.一种药物制剂,其特征在于,包括中药组合物和药学上可接受的辅料,所述中药组合物为权利要求1-3任一所述的中药组合物或由权利要求4-7任一所述的制备方法制得的中药组合物。
9.根据权利要求8所述的药物制剂,其特征在于,所述药物制剂的剂型为颗粒剂、片剂、针剂或汤剂。
10.一种治疗慢性咳嗽的片剂,其特征在于,包括权利要求1-3任一所述的中药组合物或由权利要求4-7任一所述的制备方法制得的中药组合物,以及30-40份的辅料。
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