CN107714918A - 一种清肺化痰和止咳平喘的胶囊剂药物及制备方法 - Google Patents
一种清肺化痰和止咳平喘的胶囊剂药物及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医对清肺化痰和止咳平喘的认识机理而提供一种清肺化痰和止咳平喘的胶囊剂药物,所述药物的各个组分及其质量份比如下:知母60~150g、紫苏子50~120g、玄参90~160g、罂粟壳50~120g、马兜铃30~100g、麦冬60~150g、款冬花30~100g、紫菀30~160g、枇杷叶90~160g、杏仁50~90g、百合150~550g、桑白皮60~160g、浙贝母30~100g、满山红250~550g;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种清肺化痰和止咳平喘的胶囊剂药物,特别是供清肺化痰和止咳平喘患者使用的胶囊剂药物及制备方法的领域。
二.背景技术
祖国医学认为:咳咳(cough)是一种呼吸道常见症状,由于气管、支气管黏膜或胸膜受炎症、异物、物理或化学性刺激引起,表现先是声门关闭,呼吸肌收缩,肺内压升高,然后声门张开,肺内空气喷射而出。通常伴随声音。咳咳具有清除呼吸道异物和分泌物的保护性作用。但如果咳咳不停,由急性转为慢性,常给患者带来更大的痛苦,如胸闷、咽痒、喘气等。咳咳可伴随咳痰。
气喘(asthma),为一种呼吸困难的症状。轻者活动时气促,重者在安静时亦感呼吸费力甚至不能平卧,也有部分患者气喘与活动无关,而与接触冷空气、过敏原等相关。气喘可由多种原因引起,需要及早明确病因并进行相应治疗,对症治疗是以药物治疗为主。
那么,就如何找到一种可有效清肺化痰和止咳平喘的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在清肺化痰和止咳平喘上,人们逐渐意识到了中医对清肺化痰和止咳平喘的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医对清肺化痰和止咳平喘的现状,本发明的目的是在于提供一种清肺化痰和止咳平喘的胶囊剂药物,以解决清肺化痰和止咳平喘患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效清肺化痰和止咳平喘。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种清肺化痰和止咳平喘的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
知母60~150g、紫苏子50~120g、玄参90~160g、罂粟壳50~120g、马兜铃30~100g、麦冬60~150g、款冬花30~100g、紫菀30~160g、枇杷叶90~160g、杏仁50~90g、百合150~550g、桑白皮60~160g、浙贝母30~100g、满山红250~550g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种清肺化痰和止咳平喘的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
知母70~130g、紫苏子58~105g、玄参100~140g、罂粟壳58~105g、马兜铃38~90g、麦冬70~130g、款冬花38~90g、紫菀38~140g、枇杷叶100~140g、杏仁58~80g、百合180~480g、桑白皮70~130g、浙贝母38~90g、满山红280~480g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种清肺化痰和止咳平喘的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
知母115g、紫苏子95g、玄参120g、罂粟壳95g、马兜铃80g、麦冬115g、款冬花80g、紫菀120g、枇杷叶120g、杏仁70g、百合420g、桑白皮115g、浙贝母80g、满山红420g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种清肺化痰和止咳平喘的胶囊剂药物及制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比共粉碎成(30~50目)的颗粒状包煎;
B、①将包好的原料中药放入冷开水中浸泡50min,然后再将浸泡好的药物放入砂锅内,加入原料中药重量8~9 倍的冷开水进行第一次武火煎煮,待煎煮到18min时,转文火熬制120min,滤取药液;②药渣中再次加入原料中药重量7~8 倍的冷开水进行第二次武火煎煮,待煎煮到15min时,转文火熬制110min,滤取药液;③将两次药液混合浓缩成相对密度为1.08 的清膏,然后干燥、研末和消毒后备用;
C、①按照传统制备中药胶囊剂的方法,将“B”中研磨好的细末过筛后,加入适量的微粉硅胶、微晶纤维素和淀粉,混合搅拌均匀,然后制备成胶囊剂(其胶囊锁合后总长度为23.3mm,药粉容量0.4~0.5g/粒),②继而抛光、消毒,分装密封即得。
一种清肺化痰和止咳平喘的胶囊剂药物及制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日二次服用,早晚各服一次,给药量2.5g(5粒)/次,温开水送服。7天为一疗程,服药2~3个疗程,症状消失,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
知母,性味:味苦、性寒,具有清热泻火、滋阴润燥、止渴除烦之功效,用于治疗温热病、高热烦渴、咳咳气喘、燥咳、便秘、骨蒸潮热、虚烦不眠、消渴淋浊;
紫苏子,性味:味辛、性温,具有降气、消痰、平喘、润肠之功效,用于治疗痰壅气逆、咳咳气喘、肠燥便秘;
玄参,性味:甘、苦、咸、微寒,具有清热凉血、滋阴降火、解毒散结之功效,用于治疗温热病热和营血、身热、烦渴、舌绛、发斑、骨蒸劳咳、虚烦不寤、津伤便秘、目涩昏花、咽喉喉肿痛、瘰疬痰核、痈疽疮毒;
罂粟壳,性味:酸、平,具有敛肺止咳、涩肠、定痛之功效,用于治疗久咳、久泻、久痢、脱肛、便血、心腹筋骨诸痛、滑精、多尿、白带等症;
马兜铃,性味:味苦、微辛、性寒,具有清肺降气、止咳平喘,清泄大肠之功效,用于治疗肺热咳咳、痰壅气促、肺虚久咳、肠热痔血、痔疮肿痛、水肿等症;
麦冬,性味:甘、微苦、微寒,具有养阴生津、润肺清心之功效,用于治疗肺燥干咳、虚痨咳咳、津伤口渴、心烦失眠、内热消渴、肠燥便秘、咽白喉等症;
款冬花,性味:味辛、性温,具有润肺下气,止咳化痰之功效,用于治疗新久咳咳、喘息、肺痈、喉痹等症;
紫菀,性味:性味:苦、温,具有温肺、下气、消痰、止咳之功效,用于治疗风寒咳咳气喘、虚劳咳吐脓血、喉痹、小便不利;
枇杷叶,性味:苦、辛、寒,无毒,具有清肺止咳、和胃降逆、止渴之功效,用于治疗肺热痰咳、阴虚劳咳、咳血、衄血、胃热呕哕等症;
杏仁,性味:苦、微温,有小毒,具有降气止咳平喘、润肠通便之功效,用于治疗咳咳气喘、胸满痰多、血虚津枯、肠燥便秘;
百合,性味:甘、微苦、微寒,具有养阴润肺、清心安神之功效,用于治疗阴虚久咳、痰中带血、热病后期、余热未清或情志不遂所致的虚烦惊悸、失眠多梦、精神恍惚、痈肿、湿疮等症;
桑白皮,性味:甘、寒,具有泻肺平喘、利水消肿之功效,用于治疗肺热喘咳、水肿胀满尿少、面目肌肤浮肿;
浙贝母,性味:味苦、性寒,具有清热化痰、降气止咳、散结消肿之功效,用于治疗风热或痰热咳咳、肺痈吐脓、瘰疬瘿瘤、疮痈肿毒等症;
满山红,性味:味辛、苦、性温,具有止咳祛痰之功效,用于治疗咳咳气喘痰多。
本发明药物是基于中医对清肺化痰和止咳平喘的原则,从依据清肺化痰和止咳平喘的病理机制及药理作用认为:就清肺化痰和止咳平喘,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述清肺化痰和止咳平喘的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种清肺化痰和止咳平喘的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
知母115g、紫苏子95g、玄参120g、罂粟壳95g、马兜铃80g、麦冬115g、款冬花80g、紫菀120g、枇杷叶120g、杏仁70g、百合420g、桑白皮115g、浙贝母80g、满山红420g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例2:
一种清肺化痰和止咳平喘的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
知母130g、紫苏子105g、玄参140g、罂粟壳105g、马兜铃90g、麦冬130g、款冬花90g、紫菀140g、枇杷叶140g、杏仁80g、百合480g、桑白皮130g、浙贝母90g、满山红480g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例3:
一种清肺化痰和止咳平喘的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
知母150g、紫苏子120g、玄参160g、罂粟壳120g、马兜铃100g、麦冬150g、款冬花100g、紫菀160g、枇杷叶160g、杏仁90g、百合550g、桑白皮160g、浙贝母100g、满山红550g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
典型病例
经临床诊断对清肺化痰和止咳平喘患者共1165例,年龄为32岁以上的660例,只有505例为32岁以下。1165例患者中痊愈的1045例,有效的85例,无效的35例。总有效率达97%。
Claims (3)
1.一种清肺化痰和止咳平喘的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母60~150g、紫苏子50~120g、玄参90~160g、罂粟壳50~120g、马兜铃30~100g、麦冬60~150g、款冬花30~100g、紫菀30~160g、枇杷叶90~160g、杏仁50~90g、百合150~550g、桑白皮60~160g、浙贝母30~100g、满山红250~550g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
2.根据权利要求1所述的清肺化痰和止咳平喘的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母70~130g、紫苏子58~105g、玄参100~140g、罂粟壳58~105g、马兜铃38~90g、麦冬70~130g、款冬花38~90g、紫菀38~140g、枇杷叶100~140g、杏仁58~80g、百合180~480g、桑白皮70~130g、浙贝母38~90g、满山红280~480g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
3.根据权利要求1至2所述的清肺化痰和止咳平喘的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
知母115g、紫苏子95g、玄参120g、罂粟壳95g、马兜铃80g、麦冬115g、款冬花80g、紫菀120g、枇杷叶120g、杏仁70g、百合420g、桑白皮115g、浙贝母80g、满山红420g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
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