CN108743516A - Composition and its preparation method and application with anti-ageing plain weave effect - Google Patents
Composition and its preparation method and application with anti-ageing plain weave effect Download PDFInfo
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- CN108743516A CN108743516A CN201810803154.2A CN201810803154A CN108743516A CN 108743516 A CN108743516 A CN 108743516A CN 201810803154 A CN201810803154 A CN 201810803154A CN 108743516 A CN108743516 A CN 108743516A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
A kind of composition and its preparation method and application with anti-ageing plain weave effect of the present invention, belongs to technical field of skin care.The active constituent of the composition is made of the raw material of following weight part ratio：- 51 5-60 parts of polyquaternium, 1-5 parts of lecithin, 0.1-1.0 parts of royal jelly, 1.0-10.0 parts of urea.The composition is cooperated using polyquaternium -51, lecithin, royal jelly and urea; lecithin is coordinated to form cytoprotection film by poly- doped quaternary ammonium salt -51; it constantly captures moisture and is supplied to deep layer skin, reconstituted cell compact structure, and impaired cell membrane is repaired in the multiple beneficial substance help for coordinating royal jelly to provide; promote eucaryotic cell structure normalization; and urea is coordinated to use, make skin keratin dissolving denaturation, promotes cuticula aquation; it is young flexible to make skin emolliency.Water content, the activity of enhancing Skin Cell and elastic collagen being finally reached in enhancing skin, achieve the effect that improve skin condition.The composition, which can be widely used in, to be prepared in the cosmetics with anti-ageing plain weave effect.
Description
Technical field
The present invention relates to skin care technical fields, more particularly to a kind of composition with anti-ageing plain weave effect and its preparation
Methods and applications.
Background technology
Organ one of of the skin as human body, played the role of in body surface be：1. defencive function；2. being metabolized work(
Energy；3. experiencing function；4. temp regulating function.
Our body constantly updates oneself by destroying old tissue and building new tissue, however, when we are ageing,
Our body cannot found new tissue as in the past, our skin is exactly that age-dependent tissue is built and updated
What ability was decreased obviously is evident that one of example.
Therefore, with advancing age, the fat loss of cheek, forehead causes skin wrinkle occur, loose.In addition, old
Change the separation that the fat sites of skin become, each fat pad appears like individual structure, and facial line is also not smooth enough.However
Everybody has a love of beauty, especially female consumer, always constantly pursues the product with anti-aging plain weave.
Invention content
The purpose of the present invention exactly overcomes the deficiencies of the prior art and provide a kind of composition with anti-ageing plain weave effect
And its preparation method and application, the composition has preferable anti-aging, promotes eucaryotic cell structure normalization, epidermal cell is made to bring back to life
Anti-ageing plain weave effect.
In order to achieve the above object, it adopts the following technical scheme that：
A kind of composition with anti-ageing plain weave effect, the active constituent of the composition includes the original of following weight part ratio
Material：
Above-mentioned composition is cooperated using polyquaternium -51, lecithin, royal jelly and urea.Wherein, polyquaternium-
51 be a kind of phospholipid copolymers of biocompatibility --- --- methylacryoyloxyethyl phosphocholine (MPC) and butyl methyl third
The polymer of olefin(e) acid (BMA), with human body cell film component phosphatide structure having the same, good safety and bio-compatible
Property, water solubility, bring smooth, soft, the skin surface that silk is slided.Lecithin is also referred to as liposome, is minimum hollow ball shape, ball
Wall is made of Bilayer, and Bilayer is made of phospholipid bilayer molecular layer, and lecithin itself is biological cell film
Main Components and a kind of excellent skin softener and lubricant；Queen bee breast contains abundant protein, lipid, sugar, mine
Substance etc., also containing Alphalin, compound vitamin B, Vitamin C, D and E, the micro battalion beneficial to life without element, nucleic acid etc.
Support substance, can active cell simultaneously improve the colour of skin, make up to well balanced, and epidermal cell made to bring back to life；Urea can make skin angle
Protein dissolution is denaturalized, and promotes cuticula aquation, young flexible to make skin emolliency.
The above-mentioned composition with anti-ageing plain weave effect coordinates lecithin to form cytoprotection film by poly- doped quaternary ammonium salt -51,
The multiple beneficial substance side for constantly capturing moisture and being supplied to deep layer skin, reconstituted cell compact structure, and royal jelly is coordinated to provide
It helps and repairs impaired cell membrane, promote eucaryotic cell structure normalization, enhance cell function, activating human body metabolism avoids cell
The effect of premature aging, and urea is coordinated to use, make skin keratin dissolving denaturation, promotes cuticula aquation, to make
Skin emolliency, it is young flexible.
The active constituent of the composition includes the raw material of following weight part ratio in one of the embodiments,：
The composition further includes the raw material of following parts by weight in one of the embodiments,：
It selects above-mentioned auxiliary material to coordinate, can preferably keep the function of active constituent and embodies in the product.
The royal jelly is selected from natural royal jelly in one of the embodiments,；The lecithin is selected from soybean
The lecithin in source；The preservative is selected from Phenoxyethanol；The thickener is selected from xanthan gum；The solubilizer is selected from tween-
20；The solvent is selected from water.
The invention also discloses the preparation methods of the above-mentioned composition with anti-ageing plain weave effect, include the following steps：
(1) lecithin and solubilizer are uniformly mixed, it is spare；
(2) glycerine and thickener are uniformly mixed, add water, stirring and dissolving complete；
(3) mixed solution of the above-mentioned lecithin mixed and solubilizer is added, adds poly-quaternary ammonium salt -51, royal jelly,
Urea and preservative to get.
The invention also discloses application of the above-mentioned composition with anti-ageing plain weave effect in preparing skin care item.
The skin care item include acceptable auxiliary in combinations of the above object and skin care item in one of the embodiments,
Material；Content of the composition in skin care item is 1-20%.
Acceptable auxiliary material is selected from the skin care item in one of the embodiments,：Water-soluble polymer, ultraviolet light are inhaled
Receive agent, metal ion chelation agent, polyalcohol, amino acid, organic amine, preservative, pH adjusting agent, vitamin, plant extraction essence,
At least one of antioxidant, anti-oxidant auxiliary agent, fragrance, water, moisturizing grease.
The water-soluble polymer is selected from one of the embodiments,：Arabic gum, bassora gum, galactan, Guar
Glue, locust bean gum, carragheen, pectin, algin, starch, dextran, succinoglycan, amylopectin, collagen, gelatin, card
At least one of wave nurse, acrylic acid (ester) analog copolymer；
The ultra-violet absorber is selected from：P-aminobenzoic acid series, ortho-aminobenzoic acid series, salicylic acid series, meat
At least one of cinnamic acid series, benzophenone series；
P-aminobenzoic acid series such as p-aminobenzoic acid monoglyceride etc., ortho-aminobenzoic acid series such as menthol-N-S
Cetyl Anthranilate etc., salicylic acid series such as octyl salicylate etc., cinnamic acid series such as cinnamic acid monooctyl ester etc., two
Benzophenone series such as 4- hydroxyls -3- carboxyl benzophenones etc.；
The metal ion chelation agent is selected from：At least one of EDETATE SODIUM, tetra- sodium of EDTA, EDTA；
The polyhydric alcohols are selected from：At least one of glycerine, propylene glycol, butanediol, sorbierite, dipropylene glycol；
The amino acid is selected from：The basic amino acids such as the neutral amino acids such as threonine, arginine and sulfydryl lysine, paddy Guang
At least one of amino acid derivativges such as sweet peptide；
Neutral amino acid such as threonine etc., basic amino acid such as arginine and sulfydryl lysine etc., amino acid derivativges are such as
Glutathione etc.；
The organic amine is selected from：At least one in monoethanolamine, triethanolamine, 2-Amino-2-methyl-1,3-propanediol
Kind；
The preservative is selected from：At least one of methyl hydroxybenzoate, Nipasol, Phenoxyethanol；
The pH adjusting agent is selected from：At least one of sodium hydroxide, triethanolamine, citric acid；
The vitamins is selected from：Vitamin A, vitamin C, vitamin E, pantothenic acid, panthenol, vitamin B3 and they
At least one of derivative；
The plant extraction essence is selected from：At least one of aloe, witch hazel, cucumber, lemon, lavender, rose；
The antioxidant is selected from：Tocopherols, dibutyl hydroxy toluene, butylated hydroxy anisole, gallate ester
At least one of；
The antioxidant auxiliary agent can be：At least one of phosphonic acids, maleic acid, malonic acid, phytic acid, EDTA；
The moisturizing grease is selected from：In natural plant grease, Synthetic Oil and natural animal grease and wax class emollient
At least one.
The dosage form of the skin care item includes in one of the embodiments,：Toner, smoothing toner, firming lotion, nutrition makeup
Before water, nourishing cream, massage cream, essence, eye cream, cleansing cream, skin cleaning foam, clarifying lotion, facial mask, body dew, body frost, body lotion, adornment
Breast or frost, BB frosts, CC frosts or plain face frost.
Compared with prior art, the beneficial effects of the present invention are：
The composition with anti-ageing plain weave effect of the present invention, using polyquaternium -51, lecithin, royal jelly and urea
It cooperates, coordinates lecithin to form cytoprotection film by poly- doped quaternary ammonium salt -51, constantly capture moisture and be supplied to deep layer skin,
Reconstituted cell compact structure, and impaired cell membrane is repaired in the multiple beneficial substance help for coordinating royal jelly to provide, and promotes cell
Structure normalization, enhances cell function, and activating human body metabolism avoids cell premature aging, and urea is coordinated to use, makes skin
Skin keratolysis is denaturalized, and promotes cuticula aquation, young flexible to make skin emolliency.It is finally reached enhancing skin
The activity of water content, enhancing Skin Cell and elastic collagen in skin, achievees the effect that improve skin condition.The composition
It can be widely used in and prepare in the cosmetics with anti-ageing plain weave effect.
Specific implementation mode
Below in conjunction with specific implementation method, the present invention will be described in detail, is used in the exemplary embodiment and description of the present invention
Explain the present invention, but not as a limitation of the invention.
Raw material used in following embodiment is commercially available.Wherein, No. CAS of polyquaternium -51 is 125275-25-4,
No. CAS of lecithin is 25265-71-8, and No. CAS of the CAS 8031-67-2 of royal jelly, urea is 57-13-6.
Embodiment 1
A kind of composition with anti-ageing plain weave effect, is prepared by the following method to obtain：
1, each raw material is weighed by following mass percent, it is spare.
Polyquaternium -51 is 20.0%, lecithin 4.0%, royal jelly 15.0%, urea 5.0%, Phenoxyethanol
It is water (35%) for 1.0%, xanthan gum 1.0%, glycerine 3.0%, Tween-20 16.0%, surplus.
2, preparation method.
(1) lecithin and Tween-20 are uniformly mixed spare
(2) glycerine and xanthan gum are uniformly mixed, and add water, stirring and dissolving is complete, and well pre-mixed lecithin and tween-is added
20 mixed solution adds poly-quaternary ammonium salt -51, royal jelly, urea and Phenoxyethanol, obtains the liquid composition A of consistency,
It remains spare.
Embodiment 2
A kind of composition B with anti-ageing plain weave effect, it is essentially identical with the composition of embodiment 1, it differs only in：Its
In each raw material content be polyquaternium -51 be 10.0%, lecithin 1.0%, royal jelly 3.0%, urea 1.0%,
Phenoxyethanol is 1.0%, xanthan gum 1.0%, glycerine 3.0%, Tween-20 10.0%, surplus are water (70%).
Embodiment 3
Skin care item I with anti-ageing plain weave effect, is prepared by the following method to obtain：
1, each raw material is weighed by following mass percent, it is spare.
The raw material of 1. each skin care item of table forms
2, preparation method.
(1) A is added in oil phase pot, and 80-85 DEG C is heated under stirring；
(2) water in B phases is added in water phase pot, raw material 9-11 is added under stirring, and slowly add under stirring
Enter raw material 12, be heated to 80-85 DEG C stirring to be completely dissolved uniformly, then be pumped into emulsification pot in；
(3) the A phases heated are also pumped into emulsification pot, emulsifying homogeneous 5 minutes, 80-85 DEG C keeps the temperature 30 minutes.
(4) cool down, 50 DEG C are cooled under stirring, C phases, homogeneous uniform is added；
(5) under stirring, continue to be cooled to 45 DEG C, D phases are added；
(6) it stirs evenly, discharges after detection is qualified.
Experimental example
The volunteer of 60 normal skins is chosen, 12 one group of people are divided into 5 groups and try out, once in the morning and once at night, be applied to face, wrap
Eye circumference is included to enclose, daily use it is secondary, use 28 days test using effect.
One, keratoderma hydration content is analyzed.
1, method.
Keratoderma hydration content is surveyed using cuticula hydration content measuring instrument (MoistureMeter SC).Numerical value is got over
Height indicates that keratoderma hydration levels are higher, shows that the moistening effect of product is better.
2, result.
2. keratoderma hydration content table of table
| Test sample | Skin care item I | Skin care item II | Reference examples 1 | Reference examples 2 | Reference examples 3 |
| 0 day | 91.56 | 90.89 | 90.98 | 91.32 | 91.50 |
| 28 days | 101.1 | 97.42 | 97.31 | 96.58 | 95.23 |
| 28th day moisture content of skin growth rate | 10.4% | 7.2% | 7.0% | 5.8% | 4.1% |
It can be seen from the results above that using the skin care item I of 1 composition A of the embodiment of the present invention, there is best moisturizing to imitate
Fruit.
Two, dermatoglyph is tested.
1, method.
1.1 test condition
It is required that tester stays in during entire experiment in stable experimental situation.Using neutral mild cleaning agent cleaning surface
It is (22 ± 2 DEG C) in temperature, the metastable constant temperature and humidity efficacy test laboratory that humidity is (50 ± 5) % is rested behind portion
It is carried out after 30 minutes.
1.2 test equipment：Skin microscope and viable skin surface analysis system tester SLES VC98 morals Courage+
Khazake electronic GMbh (German CK) company, imaging system are that the CCD of the skin image with ultraviolet source is special
Different test probe (S/N 1216414).
Experimental principle：Dermatoglyph by one of instrument special probe (interior that there is ultraviolet source), skin surface into
Row test.Obtain evaluation skin activated state image, by black-and-white video signal be input in the digitizer of test system into
Row processing, then input in computer, carrying out analysis by dedicated viable skin evaluation software SELS can be obtained by evaluation skin
The parameter of skin smoothness SEsm.
2, result.
Before using product, experimental side and control sides dermatoglyph parameter (skin smoothness SEsm) do not have significant difference
(p > 0.05).The variation of the front and back skin smoothness SEsm of experiment see the table below, and numerical value is smaller, illustrates that skin is more smooth.
Table 3. tests the variation of front and back skin smoothness SEsm
| Test sample | Skin care item I | Skin care item II | Reference examples 1 | Reference examples 2 | Reference examples 3 |
| 0 day | 47.84 | 48.44 | 48.55 | 47.24 | 46.56 |
| 28 days | 44.71 | 47.18 | 47.36 | 46.68 | 46.08 |
| Skin smoothness SEsm change rates | 6.5% | 2.6% | 2.5% | 1.2% | 1.0% |
It can be seen from the results above that using the skin care item I of 1 composition A of the embodiment of the present invention, there is best plain weave to imitate
Fruit.
Two, dermatoglyph is tested.
1, method.
The elasticity that crow's feet position is measured using elasticity tester (ElastiMeter), to recipient site skin elasticity into
Capable data analysis, numerical value is bigger, indicates that skin elasticity is better.
2, result.
Table 4. tests the variation of front and back skin elasticity
| Test sample | Skin care item I | Skin care item II | Reference examples 1 | Reference examples 2 | Reference examples 3 |
| 0 day | 30.35 | 30.67 | 30.63 | 31.08 | 30.49 |
| 28 days | 40.70 | 35.39 | 35.22 | 35.16 | 34.08 |
| Skin elasticity change rate | 34.1% | 15.4% | 15.2% | 13.1% | 11.8% |
It can be seen from the results above that using the skin care item I of 1 composition A of the embodiment of the present invention, there is best moisturizing to imitate
Fruit.
It can be seen that the anti-ageing and plain weave effect of the composition A of the present embodiment 1 by the comparison of the above test number, much
Higher than the effect for lacking any composition in combination, illustrate that this composition has good effect for anti-ageing plain weave.
It is provided for the embodiments of the invention technical solution above to be described in detail, specific case used herein
The principle and embodiment of the embodiment of the present invention are expounded, the explanation of above example is only applicable to help to understand this
The principle of inventive embodiments；Meanwhile for those of ordinary skill in the art, embodiment according to the present invention, in specific embodiment party
There will be changes in formula and application range, in conclusion the content of the present specification should not be construed as limiting the invention.
Claims (10)
1. a kind of composition with anti-ageing plain weave effect, which is characterized in that the active constituent of the composition includes following heavy
Measure the raw material of part ratio：
2. the composition according to claim 1 with anti-ageing plain weave effect, it is characterised in that：The activity of the composition
Ingredient includes the raw material of following weight part ratio：
3. the composition according to claim 1 with anti-ageing plain weave effect, which is characterized in that the composition further includes
The raw material of following parts by weight：
4. the composition according to claim 3 with anti-ageing plain weave effect, it is characterised in that：The royal jelly is selected from day
The royal jelly in right source；The lecithin is selected from the lecithin of soybean-source；The preservative is selected from Phenoxyethanol；The thickening
Agent is selected from xanthan gum；The solubilizer is selected from Tween-20；The solvent is selected from water.
5. the preparation method of the composition with anti-ageing plain weave effect described in claim 3 or 4, which is characterized in that including with
Lower step：
(1) lecithin and solubilizer are uniformly mixed, it is spare；
(2) glycerine and thickener are uniformly mixed, add water, stirring and dissolving complete；
(3) mixed solution of the above-mentioned lecithin mixed and solubilizer is added, adds poly-quaternary ammonium salt -51, royal jelly, urea
And preservative to get.
6. claim 1-4 any one of them has application of the composition of anti-ageing plain weave effect in preparing skin care item.
7. application of the composition according to claim 6 with anti-ageing plain weave effect in preparing skin care item, feature
It is, the skin care item include acceptable auxiliary material in claim 1-4 any one of them composition and skin care item；Institute
It is 1%-20% to state content of the composition in skin care item.
8. application of the composition according to claim 7 with anti-ageing plain weave effect in preparing skin care item, feature
It is：Acceptable auxiliary material is selected from the skin care item：It is water-soluble polymer, ultra-violet absorber, metal ion chelation agent, more
First alcohol, amino acid, organic amine, preservative, pH adjusting agent, vitamin, plant extraction essence, antioxidant, anti-oxidant auxiliary agent, perfume (or spice)
At least one of material, water, moisturizing grease.
9. application of the composition according to claim 8 with anti-ageing plain weave effect in preparing skin care item, feature
It is：The water-soluble polymer is selected from：Arabic gum, bassora gum, galactan, guar gum, locust bean gum, carragheen, fruit
Glue, algin, starch, dextran, succinoglycan, amylopectin, collagen, gelatin, carbomer, the copolymerization of acrylic acid (ester) class
At least one of object；
The ultra-violet absorber is selected from：P-aminobenzoic acid series, ortho-aminobenzoic acid series, salicylic acid series, cinnamic acid
At least one of series, benzophenone series；
The metal ion chelation agent is selected from：At least one of EDETATE SODIUM, tetra- sodium of EDTA, EDTA；
The polyhydric alcohols are selected from：At least one of glycerine, propylene glycol, butanediol, sorbierite, dipropylene glycol；
The amino acid is selected from：At least one of neutral amino acid, basic amino acid, amino acid derivativges；
The organic amine is selected from：At least one of monoethanolamine, triethanolamine, 2-Amino-2-methyl-1,3-propanediol；
The preservative is selected from：At least one of methyl hydroxybenzoate, Nipasol, Phenoxyethanol；
The pH adjusting agent is selected from：At least one of sodium hydroxide, triethanolamine, citric acid；
The vitamins is selected from：Vitamin A, vitamin C, vitamin E, pantothenic acid, panthenol, vitamin B3 and their derivative
At least one of object；
The plant extraction essence is selected from：At least one of aloe, witch hazel, cucumber, lemon, lavender, rose；
The antioxidant is selected from：In tocopherols, dibutyl hydroxy toluene, butylated hydroxy anisole, gallate ester
It is at least one；
The antioxidant auxiliary agent can be：At least one of phosphonic acids, maleic acid, malonic acid, phytic acid, EDTA；
The moisturizing grease is selected from：In natural plant grease, Synthetic Oil and natural animal grease and wax class emollient extremely
Few one kind.
10. application of the composition according to claim 6 with anti-ageing plain weave effect in preparing skin care item, feature
It is, the dosage form of the skin care item includes：Toner, smoothing toner, firming lotion, nutrition toner, nourishing cream, massage cream, essence,
Eye cream, cleansing cream, skin cleaning foam, clarifying lotion, facial mask, body dew, body frost, body lotion, adornment foremilk or frost, BB frosts, CC frosts or plain face
Frost.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810803154.2A CN108743516B (en) | 2018-07-20 | 2018-07-20 | Composition with anti-aging plain effect and preparation method and application thereof |
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| CN201810803154.2A CN108743516B (en) | 2018-07-20 | 2018-07-20 | Composition with anti-aging plain effect and preparation method and application thereof |
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| CN108743516A true CN108743516A (en) | 2018-11-06 |
| CN108743516B CN108743516B (en) | 2021-06-01 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112891241A (en) * | 2021-02-06 | 2021-06-04 | 武汉百思凯瑞生物科技有限公司 | Targeted mitochondrial skin anti-aging nano composition and preparation method and application thereof |
| CN113274338A (en) * | 2021-07-07 | 2021-08-20 | 中山爱护日用品有限公司 | Pre-makeup moisturizing cream with foundation-making function for children and preparation method thereof |
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| CN108743516B (en) | 2021-06-01 |
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