CN108741074A - A kind of nutritional supplement improved and/or assist improving people and/or animal cognition function - Google Patents
A kind of nutritional supplement improved and/or assist improving people and/or animal cognition function Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Mycology (AREA)
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- Nutrition Science (AREA)
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Abstract
The invention discloses a kind of compositions for improving and/or assisting improvement people and/or animal cognition function.The composition by following mass fractions material composition：5~20 parts of 200~800 parts of DHA, 50~200 parts of panaxoside and lutein.Test result shows：Water maze laboratory, which can shorten experiment mice, reaches home and the time used and significantly reduces errors number；Jumping test can reduce mouse diving tower errors number；Shuttle box can be obviously shortened the rat active avoidance time, shorten the passive avoidance time, increase animal active avoidance number.Showing the composition really has the function of improving and/or assists improving cognition.
Description
Technical field
The present invention relates to the nutritional supplements that a kind of improvement and/or auxiliary improve people and/or animal cognition function.
Background technology
Cognitive function refers to the mankind's various conscious sophisticated maincenters activities under waking state, including from simple
To the determination of oneself and environment, perception, understanding, arrive memory, calculate, judge and execute order, complete complex task etc..Modern times grind
Study carefully discovery, sleep deprivation, anxiety, acute and chronic psychological stress etc. have human cognitive function different degrees of influence.Recognize work(
Can be the important foundation of human perception society and completion work, maintenance and improvement cognitive function have most important theories and real meaning
Justice.A variety of nutriments, such as polyunsaturated fatty acid, phytochemical, since it improves the biological action of cognitive function,
It is increasingly becoming the hot spot of international and domestic research in recent years.
1. omega-3 polyunsaturated fatty acids (ω -3Poly Unsaturated Fatty Acids, PUFAs)
Representative species include EPA and DHA, and well-known effect has anti-inflammatory, anti-arrhythmia, adjusts the works such as blood fat
With.Research in recent years is thought, can also pass through the protection recognized to memory and Repair inhibition by the ω -3PUFAs of representative of DHA
The decline of cognitive function.In order to improve soldier battlefield stress reaction ability and military achievement, provisions office of U.S. Department of Defense, which improves, to be made
War grain ration performance study group has carried out the research of individual soldier's functional food component based on DHA, the results showed that its improve cognition,
Relieving psychological pressure, adjusting intense strain etc. have remarkable efficacy.
2. lutein (Lutein)
Lutein category carotenoids class has very strong antioxidant activity.Lutein is most important class Hu trailing plants in brain tissue
Bu Su classes, brain tissue lutein concentration is related to adult's macular pigment concentration, and adult's macular pigment concentration and cognition phase
It closes, therefore scientist infers that lutein is related to cognitive function.Have studies have shown that individually supplement lutein can obviously improve it is small
Mouse Active Learning, memory retention, adult, which supplements lutein, can also improve cognitive function, may be with lutein antioxygen
Change, anti-inflammatory, adjusting cells apoptosis is related.
3. panaxoside (Ginsenoside)
Panaxoside belongs to steroid compound, research shows that there is panaxoside multiple target point, too many levels synthesis to promote to learn
The effect of memory is practised, it can be by influencing the metabolism of central nervous system nerve mediator, improving nerve cell membrane fluidity, enhancing body
The effects that the utilization rate of blood oxygen, improves the human-subject test of body.The Fourth Military Medical University applies panaxoside Pd 30mgkg-1Energy
Spontaneous activity ability and ability of learning and memory caused by improvement+Gz, rat hippocampal neuron withers after reduction+Gz exposures
It dies.
There is no the replenishers for being used in compounding three at present, therefore a kind of three of exploitation is used in compounding more preferably to improve and recognize
Know that the nutritional supplement of function has important practical significance.
Invention content
The object of the present invention is to provide a kind of combinations for improving and/or assisting improvement people and/or animal cognition function
Object.
The improvement and/or auxiliary improve the composition of people and/or animal cognition function, by the substance of following mass fractions
Composition：5~20 parts of 200~800 parts of DHA, 50~200 parts of panaxoside and lutein.
Preferably：The improvement and/or auxiliary improve the composition of people and/or animal cognition function, by following mass parts
Several material compositions：5~15 parts of 300~600 parts of DHA, 80~150 parts of panaxoside and lutein.
More preferably：The improvement and/or auxiliary improve the composition of people and/or animal cognition function, by following quality
The material composition of number：10 parts of 500 parts of DHA, 100 parts of panaxoside and lutein.
The cognitive function includes：Learning functionality, memory function, judgement, computing capability etc..
The present invention also provides the nutritional supplements that a kind of improvement and/or auxiliary improve people and/or animal cognition function.
Nutritional supplement provided by the present invention, active constituent are of the present invention for improving and/or assisting changing
The composition of philanthropist and/or animal cognition function.
The people of the artificial health or the people with cognitive disorder disease.
The animal is the animal of health or the animal with cognitive disorder disease.
The disease with cognitive disorder is selected from following at least one：Dementia, the cognitive disorder of non-dementia property, study
Obstacle and memory disorders.
The cognitive function includes：Learning functionality, memory function, judgement, computing capability etc..
When needs, one or more pharmaceutically acceptable carriers can also be added in above-mentioned nutritional supplement.
The carrier includes diluent, excipient, filler, adhesive, wetting agent, disintegrant, the absorption enhancement of pharmaceutical field routine
Other adjuvants such as flavouring agent, sweetener etc. can be also added in agent, surfactant, absorption carrier, lubricant etc..
Improvement provided by the invention and/or auxiliary improve the composition of people and/or animal cognition function, and water maze laboratory can
Shorten experiment mice and reach home and the time used and significantly reduces errors number；Jumping test can reduce mouse diving tower mistake time
Number；Shuttle box can be obviously shortened the rat active avoidance time, shorten the passive avoidance time, increase animal active avoidance
Number.Show that the composition has the function of improving and/or assists improving cognition.
Specific implementation mode
The method of the present invention is illustrated below by specific embodiment, but the present invention is not limited thereto, it is all at this
The all any modification, equivalent and improvement etc. done within the spirit and principle of invention, should be included in the protection model of the present invention
Within enclosing.
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
Embodiment 1 improves and/or assists the safety evaluatio for improving people and/or animal cognition function nutrition replenishers real
It tests
1. safety evaluatio is tested
1. experiment purpose
Observation improves and/or auxiliary improves generated acute toxicity after the administration of cognitive function nutritional supplement Mouse oral
Reaction and death condition, determine the safety of prescription.
2. experiment material
Experimental animal：CD-1 (ICR) mouse 40, ♀ ♂ are fifty-fifty, 18~22g of weight, non-inbred strais closed colony.By China
Food and medicine is examined and determine research institute and is provided.Licensing is numbered：SCXK (capital) 2014-0013.
Laboratory sample：Improve and/or auxiliary improves the battalion that cognitive function nutritional supplement is made of three kinds of primary raw materials
Support replenishers.Its main composition object is that (health control company, product batch number are looked forward in soft capsule, DHA70%, Shanghai to DHA
20170224), lutein (purity 20%, Royal DSM, product batch number UE01606017), panaxoside (ginseng root extract,
80%UV, Jinlin Changqing Ginseng Co., Ltd.).The present embodiment improves cognitive function nutritional supplement according to improvement and/or auxiliary
Human body recommended amounts everyone daily DHA500mg, lutein 10mg, panaxoside 100mg, according to《Health food is examined and evaluation skill
Art specification》It is required that showing that the equivalent dosages of mouse for 100 times of amounts for being equivalent to the possible intake of human body are daily by body surface area conversion
Respectively DHA10.25gkg-1, lutein 0.205gkg-1, panaxoside 2.05gkg-1, test dose is set as DHA
15g·kg-1, lutein 0.3gkg-1, panaxoside 3gkg-1, that is, improve cognition trophic function replenishers active principle and contain
Measure 18.3gkg-1(dosage 26.68gkg-1), it is equivalent to 146.34 times (18.3 × 3/ of the possible intake of human body
36.9 × 60/0.61=146.34 times).Laboratory sample matches：(DHA active principles contain DHA soft capsule contents 10.715g
Measure 7.5g), lutein 0.75g (lutein active principle content 0.15g), panaxoside 1.875g (panaxoside active principles
Content 1.5g), peanut oil (Laiyang Shandong Province Lu Hua peanut oil Co., Ltd) is added and is settled to 30ml, is uniformly mixed, is configured to
0.445g·ml-1(active principle content 0.305gml-1) solution.
3. experimental method
2 groups are randomly divided into after above-mentioned 40 mouse adaptable feds 3d, every group 20, ♀ ♂ are fifty-fifty.Fasting before animal administration
It can't help water 16h, administration group animal presses 26.68gkg-1Dosage gastric infusion, administered volume 0.3ml10g-1, interior administration for 24 hours
It is secondary, two minor tick 8h.Control group gives isometric peanut oil.Animal poisoning reaction and death condition after observation is administered every time,
Toxic reaction symptom, time of occurrence, performance degree and death time are recorded, 14d is observed continuously, the before record administration and after administration
3d, 7d, 10d, 14d the weight of animals.
4. experimental result
Appetite is shown as after administration in 48h to decrease, it is rear to restore normal.Observation experiment administration group early period mouse in 14d
Weight is declined, compared with the control group significant difference (P<0.05), gradually restoring after a week, be shown in Table 1~2.Outside
Compared with the control group without significant change, 14d is interior without animal dead for sight, behavioral activity, the state of mind etc..
Maximum tested amount is 26.68gkg-1(18.3gkg containing active ingredient-1), it is equivalent to quasi- dosage (0.61g/d)
1800 times.
Mouse maximal tolerance times=0.366/20 × 60000/0.61=1800 (again)
Note：Every mouse maximum dosage-feeding=liquor strength × administered volume × administration number of times=0.305g/ml × 0.6ml
× 2 times=0.366
1 male mice changes of weight of table (N=10)
* P compared with the control group<0.05.
2 female mice changes of weight of table (N=10)
* P compared with the control group<0.05.
5. experiment conclusion
Improve and/or assists improving cognitive function nutritional supplement to the maximum tested amount of Mouse oral being 26.68gkg-1
(active ingredient 18.3gkg-1), it is equivalent to 1800 times of human body recommended dose.14d is observed without dead mouse, according to《Health care is eaten
Product examine is tested and assessment technique specification》" acute toxicity in " health food Toxicological evaluation program and method of inspection specification "
Experiment " requires, it is believed that nutritional supplement of the present invention is without overt toxicity.
Embodiment 2, the functional evaluation experiment for improving and/or assist improving people and/or animal cognition function nutrition replenishers
1. experiment purpose
According to《Health food is examined and assessment technique specification》" function of health food assessment process and inspection party's regulation
In model " " the auxiliary improving memory function method of inspection ", the functional evaluation zoopery of nutritional supplement, including labyrinth reality are completed
It tests, Jumping test and Shuttle box, verifies the functionality of nutritional supplement.
2. experiment material
Experimental animal：SPF grades of animal BalB/c male mices, SD male rats, animal are real from Department Of Medicine, Peking University
Test animal science portion, credit number SCXK (capital) 2016-0010, animal quality quality certification number 11804700004191,
11804700004216.Zoopery environment keeps 23.1 ± 0.9 DEG C of temperature, relative humidity 52.8 ± 3.0%, rate of ventilation 10
~20 times/h, optical illumination：Secretly=12h：12h.Animal feeding is in base box, and mouse is per 8~10, box, by acquisition qualification authentication
Personnel carry out feeding management.Bedding and padding and cage tool after disinfection are replaced 2 times a week, and clean environment is dried in keeping box；Add daily
Add feed and drinking-water, keeps the free diet activity of animal.It is Beijing China Fukang biotechnology share to be fed with rats and mice and maintain feed
Institute of Experimental Animals, Chinese Academy of Medical Sciences of Co., Ltd produces, credit number SCXK (capital) 2014-0008.
Instrument and equipment：Water maze (LW- II, institute of Materia Medica,Chinese Academy of Medical Sciences), 2 mouse diving tower instrument of STT (China
Academy of Medical Sciences institute of materia medica), YLS-17B keeps away dark shuttle tester (Jinan Yi Yan development in science and technology Co., Ltd), METTLER
TOLEDO balances (AL104, plum Teller-support benefit instrument Shanghai Co., Ltd).
Dosage and grouping：Foundation《Health food is examined and assessment technique specification》And preliminary result is related to toxicity test
Data, this experiment set nutritional supplement group, positive controls and negative control group.Wherein nutritional supplement group be divided into for it is low,
Middle and high 3 dosage groups, according to human body recommended amounts DHA 500mg/ people d, lutein 10mg/ people d, panaxoside 100mg/
People d is converted with standardized human body's weight 60kg, and it is low dosage to be calculated and be equivalent to 10 times of amounts of human body recommended intake
Group, 20 times of amounts are middle dose group, and 30 times of amounts are high dose group.It is right that positive controls are divided into DHA positive controls, the lutein positive
According to group and panaxoside positive controls, gavage gives the DHA for being equivalent to 30 times of human body recommended intake amounts, lutein respectively
And panaxoside.Negative control group separately is set, gavage gives peanut oil.
3. experimental method
Water maze laboratory：Inbred strais male BalB/c mouse 105 are selected in experiment, and 15~17g of weight is randomly divided into feminine gender
Control group, by test product low dose group (human body recommended intake 10 times amount), by test product middle dose group (20 times of human body recommended intake
Amount), by test product high dose group (human body recommended intake 30 times amount), DHA positive controls, lutein positive controls and ginseng
7 groups of saponin positive controls, every group 15.30d, administered volume 0.2ml10g is administered in continuous gavage-1.31d starts to train,
Successive administration during training, 1 time/d.Labyrinth swimming lane depth of water 9cm, 20 ± 2 DEG C of water temperature.The mouse training time is limited to 120s,
The mouse that do not reach home in 120s is denoted as 120s.Mouse is placed near ladder before training for the first time, it is made to climb up automatically
Three times, mouse is placed near ladder train every time later before, facing away from stair, it is made to climb up automatically 1 time.Experiment stage by stage into
Row, apparent motion object school grade gradually lengthen distance.Kept off A at first baffle when training for the first time extremely, from A train,
Record the time reached home from A points.Second of training lengthens distance, and since at B, this distance is trained 3 times, until number of animals
80% or more reach home in 2min after extend distance again, record each mouse respectively and reach home the required time from B points every time
With the number that mistake occurs.Last test is carried out from starting point, and mouse is placed on starting point, is recorded when reaching home required from starting point
Between and occur mistake number.Every time when training, to being not up to the mouse of terminal in 2min, it should guide it to up to terminal, from end
Come on the stair of point, achievees the purpose that trained.Every time training or when test by head towards starting point.Finally calculate each group animal 5
Total errors number of secondary training and test, the total time reached home and the total number of animals (percentage that do not reach home in 2min
Rate).Experimental result determination method：Experimental group and control group ratio, experimental group are reached home time used or before reaching home
Errors number is considerably less than the number of animals reached home in control group or 2min and is significantly more than control group, and through statistical test
Difference is significant, and any of which item index is positive, can determine whether this index positive.
Jumping test：Inbred strais male BalB/c mouse 84,16~18g of weight, experimental animal and grouping are selected in experiment
Same maze experiment, every group 12.Successive administration 30d, 31d start to train, and animal is put into reaction chamber (on platform, under platform) and is fitted
Environment 3min is answered, then by the copper grid in animal placing response case, passes to the alternating current of 36V immediately, animal is shocked by electricity,
Normal reaction is to jump onto case interior insulation platform to avoid noxious stimulation.Most animals may again or repeatedly skip on copper grid,
Platform is snapped back by electric shock again.After training is primary, animal is placed on the platform in reaction chamber, each mouse in 5min is recorded and jumps
The errors number of lower platform and the incubation period for jumping off platform for the first time, in this, as school grade.48h recasts are test, by mouse
It is placed on platform, records that each mouse jumps off the incubation period of platform for the first time, number of shocks and the animal shocked by electricity are total in each mouse 3min
Number, while calculating the percentage for wrong reaction animal occur.Experimental result determination method：If test sample group and control group ratio
Compared with incubation period is obviously prolonged, and errors number or the number of animals for jumping off platform are considerably less than control group, and difference is significant, above
In three indexs, any one index is positive, can determine whether this index positive.
Shuttle box：SD male rats 70,150~170g of weight are selected in experiment, be randomly divided into negative control group, by
Test product low dose group (human body recommended intake 5 times amount), by test product middle dose group (10 times of amounts of human body recommended intake), by test product
High dose group (15 times of amounts of human body recommended intake), DHA positive controls, lutein positive controls and the panaxoside positive are right
According to organizing 7 groups, every group 10.Successive administration 30d is tested, is trained, first allows animal free activity 5min in test box, to disappear
Except exploratory reflex.Rat is placed in shuttle experimental box electric shock area.It first gives in conditional stimulus 25s, rear 10s while giving electric thorn
Swash.If rat escapes to safety zone to be active avoidance response in bright light 15s, just escape after electric shock to safety zone to be that passive avoidance is anti-
It answers.After training for several times, rat can gradually form active avoidance conditioned response, to be remembered.Training 25s every time,
Cycle-index is set as 30 times, is trained five times altogether.When formal experiment, rat is placed in shuttle box electric shock area, setting cycle time
Number is 50 times, records reaction of animals number, animal active avoidance time, animal passive avoidance time, animal active avoidance rate.It is real
Test result judgement method：If experimental group actively and/or passively avoids the time and is significantly shorter than control group, difference is significant, can sentence
The fixed index is positive.
4. statistical method
For reaction times, experimental animal number (percentage) is completed as enumeration data, uses X2It examines.For meterings such as times
Index counts in accordance with the following methods：(1) it is with One-Sample Kolmogorov-Smirnov Test inspection datas first
It is no to meet normal distribution, if P > 0.05, data homogeneity is carried out with Homogeneity of variance test methods
It examines, if P≤0.05, carries out Kruskal-wallis inspections.(2) if through Homogeneity of variance
Test data are uniform (examining P > 0.05), then carry out variance analysis test (F inspections)；If Homogeneity of
The result that variance test are examined significantly (P≤0.05), then carries out Kruskal-wallis inspections.(3) if variance analysis
Inspection result significantly (P≤0.05), then further carries out multiple comparative test with Dunnett T inspections；If variance analysis knot
Not significantly (P > 0.05), then statistics terminates fruit.(4) if Kruskal-wallis inspection results are notable (P≤0.05), into
One step carries out multiple comparative test with two group non-parametric test methods；If not notable (the P > of Kruskal-wallis inspection results
0.05), then statistics terminates.
5. experimental result
Water maze laboratory：It the results are shown in Table 3~5.Compared with negative control group, lutein group, panaxoside group, DHA groups, change
Kind and/or auxiliary, which improves the middle and high dosage group of cognitive function nutritional supplement, can be obviously shortened the time that mouse is reached home, and unite
Meter learns significant difference (P<0.05).Compared with negative control group, improve and/or assist improving each dose of cognitive function nutritional supplement
Amount group can obviously reduce Mice water maze errors number, there is pole significant difference (P<0.01).Compared with negative control group, change
Kind and/or auxiliary improves the middle and high dosage group of cognitive function nutritional supplement, DHA groups rise to the number of mice up to terminal, unites
Meter learns significant difference (P<0.05).It is wrong to reduce water maze laboratory mouse compared with negative control group for panaxoside group and DHA groups
Accidentally number, statistically significant (P<0.05).Middle dose group can reduce water maze laboratory mouse compared with panaxoside control group
Errors number, statistically significant (P<0.05).
With negative control group ratio, improves and/or auxiliary improvement cognitive function nutritional supplement can be obviously shortened mouse arrival
Time used in terminal reduces errors number and increases the number of mice reached home, and the significant difference of statistical test, prompting should
Item index result is positive.Compared with positive controls (lutein group, panaxoside group, DHA groups), improve cognitive function nutrition
Replenishers can shorten mouse and reach home the time used, and middle dose group can reduce water maze reality compared with panaxoside control group
Mouse wrong times are tested, prompts to improve and/or auxiliary improves cognitive function nutritional supplement compound prescription better than the list in prescription
One ingredient.
Table 3 to water maze laboratory mouse reach home the time influence (N=15)
Note：F=3.051, P=0.122, compared with negative control group, a：P < 0.05, aa：P < 0.01；With lutein pair
It is compared according to group, b：P < 0.05, bb：P < 0.01；Compared with panaxoside control group, c：P < 0.05, cc：P < 0.01；With DHA
Control group is compared, d：P < 0.05, dd：P < 0.01.
Table 4 to water maze laboratory mouse wrong times influence (N=15)
Note：F=8.097, P=0.000, compared with negative control group, a：P < 0.05, aa：P < 0.01；With lutein pair
It is compared according to group, b：P < 0.05, bb：P < 0.01；Compared with panaxoside control group, c：P < 0.05, cc：P < 0.01；With DHA
Control group is compared, d：P < 0.05, dd：P < 0.01.
Table 5 to water maze laboratory mouse reach home total number of animals influence (N=15)
Note：1. referring to total number of animals of 5 training and test.X2It examines, compared with the control group, a：P < 0.05, aa：P
< 0.01.
Mouse Jumping test：It the results are shown in Table 6.Improve and/or auxiliary improves the middle and high dosage group of cognitive function nutritional supplement
Mouse diving tower errors number is can obviously reduce, with the more significant difference (P of negative control group<0.05), each dosage group, which has, prolongs
Long mouse incubation period and the effect trend of platform animal percentage of jumping off is reduced, but compared with the control group without significant difference,
Without statistical significance (P>0.05).Middle dose group is compared with lutein group, DHA groups and high dose group and lutein group
It compares, mouse diving tower errors number can be substantially reduced, there is significant difference (P<0.05).
With negative control group ratio, improves and/or auxiliary improvement cognitive function nutritional supplement can reduce mouse diving tower mistake
Accidentally number, the significant difference of statistical test prompt this index result to be positive.Middle dose group and lutein group and DHA
Group, high dose group can reduce mouse diving tower errors number compared with lutein group, prompt to improve and/or auxiliary improves cognition work(
Energy nutritional supplement compound prescription is better than the single component in prescription.
Table 6 to Jumping test mouse incubation period and errors number influence (N=12)
Note：Incubation period F=1.168, P=0.335, errors number F=1.502, P=0.214, with negative control group phase
Than a：P < 0.05, aa：P < 0.01；Compared with lutein control group, b：P < 0.05, bb：P < 0.01；With panaxoside pair
It is compared according to group, c：P < 0.05, cc：P < 0.01；Compared with DHA control groups, d：P < 0.05, dd：P < 0.01.X2Examine P >
0.05
Rat Shuttle box：It the results are shown in Table 7.Compared with negative control group, improve and/or assist improving function nutrition benefit
Rat active avoidance time, active avoidance number and passive avoidance time (P can be obviously shortened by filling the middle and high dosage group of agent<0.05
Or P<0.01).Compared with lutein group, improves and/or assist the improvement middle and high dosage group of cognitive function nutritional supplement can be bright
It is aobvious to shorten rat active avoidance time, active avoidance number and passive avoidance time (P<0.05), improve and/or assist improving and recognize
Know that function nutrition replenishers high dose group can also be obviously shortened rat active avoidance time (P compared with panaxoside group<0.05).Change
Kind and/or auxiliary improves each dosage group of cognitive function nutritional supplement and positive controls to rat active avoidance animal percentage
It has no significant effect (P > 0.05).
With control group ratio, improves and/or auxiliary improvement cognitive function nutritional supplement can be obviously shortened rat active avoidance
Time, improves animal active avoidance number at the passive avoidance time, and the significant difference of statistical test prompts this index knot
Fruit is positive.Compared with lutein group, improves and/or assist improvement cognitive function nutritional supplement that can shorten rat and actively return
It keeps away the time, the passive avoidance time, improve animal active avoidance number, high dose group can also be reduced compared with panaxoside control group
Mouse active avoidance number prompts to improve and/or auxiliary improves cognitive function nutritional supplement compound prescription better than in prescription
Single component.
Table 7 to Shuttle box rat active avoidance response influence (N=10)
Note：Active avoidance time F=2.720, P=0.041, active avoidance number F=2.405, P=0.063 are passive to return
Keep away time F=3.051, P=0.041, X2Examine P > 0.05, compared with negative control group, a：P < 0.05, aa：P < 0.01；
Compared with lutein control group, b：P < 0.05, bb：P < 0.01；Compared with panaxoside control group, c：P < 0.05, cc：P <
0.01；Compared with DHA control groups, d：P < 0.05, dd：P < 0.01.
6. experiment conclusion
Under this experimental condition, the improvement of various dose and/or auxiliary improve cognitive function nutritional supplement (101.67mg
kg-1、203.33mg·kg-1、305.00mg·kg-1) feed experimental animal 30d after carry out water maze laboratory, Jumping test respectively
And Shuttle box.The results show that improving and/or assisting improvement cognitive function nutritional supplement water maze laboratory that can shorten experiment
Mouse reach home time used, reduce errors number and increase the number of mice reached home；Jumping test can reduce mouse jump
Platform errors number；Shuttle box can be obviously shortened the rat active avoidance time, shorten the passive avoidance time, increase animal actively
Avoid number, through the significant difference of statistical test, there is statistical significance.As a result it prompts：Improve cognitive function nutrition to mend
Agent water maze laboratory, Shuttle box and Jumping test result is filled to be positive, according to《Health food is examined advises with assessment technique
Model》" function of health food assessment process and method of inspection specification " requires, it is possible to determine that nutritional supplement of the present invention, which has, to be changed
Kind and/or auxiliary improves the function of cognition.
In summary, improvement provided by the invention and/or auxiliary improve the composition of people and/or animal cognition function, water
Maze experiment, which can shorten experiment mice, reaches home and the time used and significantly reduces errors number；Jumping test can reduce mouse jump
Platform errors number；Shuttle box can be obviously shortened the rat active avoidance time, shorten the passive avoidance time, increase animal actively
Avoid number.Show that the composition has the function of improving and/or assists improving cognitive function.
Claims (8)
1. a kind of composition for improving and/or assisting improvement people and/or animal cognition function, by the object of following mass fractions
Matter forms：5~20 parts of 200~800 parts of DHA, 50~200 parts of panaxoside and lutein.
2. composition according to claim 1, it is characterised in that：The improvement and/or auxiliary improve people and/or animal is recognized
The composition for knowing function, by the material composition of following mass fractions：300~600 parts of DHA, 80~150 parts of panaxoside and leaf
5~15 parts of flavine.
3. composition according to claim 2, it is characterised in that：The improvement and/or auxiliary improve people and/or animal is recognized
The composition for knowing function, by the material composition of following mass fractions：10 parts of 500 parts of DHA, 100 parts of panaxoside and lutein.
4. composition described in any one of claim 1 to 3, it is characterised in that：The cognitive function includes：Learn work(
Energy, memory function, judgement and computing capability.
5. composition according to any one of claims 1 to 4 improves preparing and/or assists improving people and/or animal cognition
Application in the nutritional supplement of function.
6. application according to claim 5, it is characterised in that：The cognitive function includes：Learning functionality, memory function,
Judgement and computing capability.
7. a kind of improvement and/or auxiliary improve the nutritional supplement of people and/or animal cognition function, active constituent is wanted for right
Seek the composition described in any one of 1~4.
8. nutritional supplement according to claim 7, it is characterised in that：The cognitive function includes：Learning functionality, memory
Function, judgement and computing capability.
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| CN113229499A (en) * | 2021-05-28 | 2021-08-10 | 中国人民解放军海军军医大学 | Nutritional supplement for improving mental performance in high temperature environment |
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|---|---|---|---|---|
| CN101548981A (en) * | 2008-03-31 | 2009-10-07 | 中国医学科学院药物研究所 | Application of ginsenosides Rg1, Rh1 and Ppt to resistance of cognitive competence and study memory function disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101548981A (en) * | 2008-03-31 | 2009-10-07 | 中国医学科学院药物研究所 | Application of ginsenosides Rg1, Rh1 and Ppt to resistance of cognitive competence and study memory function disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113229499A (en) * | 2021-05-28 | 2021-08-10 | 中国人民解放军海军军医大学 | Nutritional supplement for improving mental performance in high temperature environment |
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