CN108741042A - It is a kind of to adjust intestinal flora, composition that improvement is remembered and products thereof and application - Google Patents
It is a kind of to adjust intestinal flora, composition that improvement is remembered and products thereof and application Download PDFInfo
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- CN108741042A CN108741042A CN201810658100.1A CN201810658100A CN108741042A CN 108741042 A CN108741042 A CN 108741042A CN 201810658100 A CN201810658100 A CN 201810658100A CN 108741042 A CN108741042 A CN 108741042A
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- galactooligosaccharide
- intestinal flora
- memory
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- glidant
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- 230000000968 intestinal effect Effects 0.000 title claims abstract description 60
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 230000006872 improvement Effects 0.000 title description 5
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract description 109
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract description 109
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract description 90
- 241001506047 Tremella Species 0.000 claims abstract description 49
- 150000004676 glycans Chemical class 0.000 claims abstract description 49
- 239000005017 polysaccharide Substances 0.000 claims abstract description 49
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 49
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims abstract description 48
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 48
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims abstract description 47
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims abstract description 47
- 229940090949 docosahexaenoic acid Drugs 0.000 claims abstract description 45
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims abstract description 40
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims abstract description 40
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000012138 yeast extract Substances 0.000 claims abstract description 26
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 24
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- 235000019152 folic acid Nutrition 0.000 claims abstract description 24
- 239000011724 folic acid Substances 0.000 claims abstract description 24
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000377 silicon dioxide Substances 0.000 claims description 5
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 4
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 4
- 125000005629 sialic acid group Chemical group 0.000 claims description 3
- 235000012241 calcium silicate Nutrition 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
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- 239000000047 product Substances 0.000 description 62
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- DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical class CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 description 2
- GLCGEJFIZRSXBL-UHFFFAOYSA-N dodeca-1,3,5,7,9,11-hexaene Chemical compound C=CC=CC=CC=CC=CC=C GLCGEJFIZRSXBL-UHFFFAOYSA-N 0.000 description 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 description 2
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- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 description 1
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
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- 241000305071 Enterobacterales Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
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- 229940039856 aricept Drugs 0.000 description 1
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- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
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- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
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- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
- A23L33/145—Extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to field of health care products; a kind of composition for having and adjusting intestinal flora, auxiliary improvement of memory double effects is specifically provided; it includes tremella polysaccharides, galactooligosaccharide, stachyose, docosahexaenoic acid and sialic acid, and can be properly added yeast extract, folic acid and taurine to further strengthen effect of the composition in terms of adjusting intestinal flora and auxiliary improvement of memory.It is played a role by the contact collaboration between brain-gut axis between said components, add glidant, and a kind of adjustings intestinal flora and auxiliary improvement of memory aspect are prepared by the way of equivalent gradient premix have the health product of remarkable result, and further disclose the application of the product.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of to adjust intestinal flora, improving the composition remembered and its production
Product and application.
Background technology
Live away from home miscellaneous microorganism in the gastrointestinal tract of Healthy People, these microorganisms are known as intestinal flora, gene
Sum is about 150 times of human body gene quantity, is had an important influence on to human life activity.Intestinal flora group according to a certain percentage
It closes, conditions each other between each bacterium, depend on each other for existence, form a kind of ecological balance on quality and quantity, once body internal and external environment becomes
Changing, especially prolonged application broad-spectrum antibiotic, sensitive intestines bacterium is suppressed, and not repressed bacterium seizes the opportunity breeding, so as to cause
Flora imbalance, normal physiological combination is destroyed, and generates pathologic combination, clinical symptoms is caused to be known as intestinal bacilli illness
Disease.Adjustment intestinal flora is mainly carried out by modes such as diet modification, prebiotic-supplemented, probiotics preparations, and severe patient also may be used
It is treated by antibacterials.
Memory is that human brain crosses experience the memorize of thing, holding, reproduces or re-recognize, and is to carry out the higher mentals such as thinking, the imagination
Movable basis.With modern society's study, work, the accelerating rhythm of life, people have to face the pressure from various aspects
Power, more and more people just by ability of learning and memory decline, encephalasthenia perplexed, and unhealthy emotion, insomnia, disease,
Age growth, overstrain one's nerves etc. can lead to failure of memory to some extent.There are mainly two types of the modes for usually improving memory,
Drug therapy and Dietary frequency.Drug therapy, the drug mainly transmitted using neurotransmitter is improved, such as Doneppezil Hydrochloride
(Aricept) etc..Or the anti-oxidation medicine using the generation for reducing free radical, such as selegiline.Dietary frequency is then supplements more
Some can improve the food of memory.Being commonly used for main component in the product for improving memory on the market mainly has lipid, protein
With amino acids, minerals and trace element, vitamin, Chinese herbal medicine etc..
In recent years, studies have found that intestinal flora is in the performance of the physiological functions such as human immunity, endocrine, nerve and all
Key player is play in the generation of more diseases.More and more research shows that intestinal flora can not only influence intestinal health,
But also central nervous system can be influenced.Intestinal microbiota is mainly by discharging in bacterium substrate, tunning and enteron aisle
Secretion factor etc. influences enteron aisle and hormone, the immune, vagus nerve in brain pathways influences the hair of brain to adjust brain
It educates and function.The disturbance of these systems leads to the change of stress reaction and behavior, and the psychotic symptoms of pressure correlation such as anxiety
Include that height between irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) coexists rate and further demonstrates with enterogastric diseases
Contacting between intestinal flora and nervous centralis.
Brain-gut axis is the bidirectional modulation axis of central nervous system and gastrointestinal function interaction comprising nervous centralis
System (CNS), autonomic nerves system (ANS), hypothalamic-pituitary-adrenal (HPA) axis, the knots such as nervous system (ENS) in enteron aisle
Structure, functions are mutually coordinated.Cerebral limbic system simultaneously participates in the adjusting to gastrointestinal tract and mood, therefore visceral malaise is normal
With symptoms such as emotional reactions, decrease of memory, and emotional change, hypomnesia also often influence viscera function.Psychomotor test Battrey can
The nervous activity of central nervous system region of interest is activated, while by signal by being passed under brain-gut axis, change gastrointestinal tract dynamia,
Mucosal Immunity is activated, gut muco-membranous barrier function is destroyed.
Current there are many drug, food or the health products that adjust intestinal flora or improvement memory on the market, but fecund greatly
There is certain disadvantage mostly in product.On the one hand, ingredient is single the effect of product, and curative effect is poor；On the other hand, most products needle
To one of which symptom, few contacts using between brain-gut axis, cooperate with it is between the two mutually promote and restrictive function,
Intestinal bacilli illness is treated simultaneously and improves memory.Patent application CN 105055457A disclose clostridium butyricum and are controlled in preparation
The application in Alzheimer composition is treated and prevented, the effect of intestinal bacilli illness can be improved using clostridium butyricum, passed through
Relationship between brain-gut axis improves brain tissue activities of antioxidant enzymes, anti-nerve cell apoptosis, improving studing ability.But
It plays effect only with a kind of probiotics of clostridium butyricum, single component in this method and is limited to, curative effect is not good enough.Patent application
CN104839735A discloses several compound actions of compound probiotic powder, stachyose, galactooligosaccharide, tremella polysaccharides, has bright
The whole intestines micro-ecological environment of aobvious improvement and digestion-aid effect, but wherein compound probiotic powder is mostly active probiotic, in vivo
It is vulnerable to the influence of environmental change.
Invention content
Based on the defect of the above-mentioned prior art, the present invention is by tremella polysaccharides, galactooligosaccharide, stachyose, 22 carbon six
Olefin(e) acid and sialic acid combine, and utilize the work of synergic adjustment intestinal flora between tremella polysaccharides, galactooligosaccharide, stachyose three
With, the bidirectional modulation axis to be interacted by central nervous system and gastrointestinal function, and it is aided with docosahexaenoic acid and saliva
Liquid acid, further improves memory, has the double effects for considerably adjusting intestinal flora and improving memory.
The present invention provides a kind of composition for adjusting intestinal flora, improving memory, including tremella polysaccharides, oligomeric gala
Sugar, stachyose, docosahexaenoic acid (DHA) and sialic acid.
Further, the composition in parts by weight, including 15-25 parts of tremella polysaccharides, 20-45 portions of oligomeric galas
Sugar, 8-15 parts of stachyoses, 0.005-0.03 parts of docosahexaenoic acids and 0.02-0.1 parts of sialic acids.
Further, the composition in parts by weight, including 18-23 parts of tremella polysaccharides, 25-40 parts it is low
Poly- galactolipin, 10-15 part stachyose, 0.01-0.03 parts of docosahexaenoic acids and 0.04-0.08 parts of sialic acids.
Further, the composition in parts by weight, including 20 parts of tremella polysaccharides, 40 portions of oligomeric galas
Sugar, 10 parts of stachyoses, 0.02 part of docosahexaenoic acid and 0.04 part of sialic acid.
Further, further include one or more in yeast extract, folic acid and taurine in the composition.
Further, the composition further includes 2-8.5 parts of yeast extracts, 0.0001- in parts by weight
It is one or more in 0.0005 part of folic acid and 0.11-0.14 parts of taurines.
Further, the composition further includes 4-7 parts of yeast extracts, 0.0002- in parts by weight
It is one or more in 0.0004 part of folic acid and 0.12-0.13 parts of taurines.
Further, the composition further includes 6 parts of yeast extracts, 0.0004 part of folic acid in parts by weight
With it is one or more in 0.12 part of taurine.
Further, the composition in parts by weight, by 20 parts of tremella polysaccharides, 40 parts of galactooligosaccharides, 10
Part stachyose, 0.02 part of docosahexaenoic acid, 0.04 part of sialic acid, 6 parts of yeast extracts, 0.0004 part of folic acid and 0.12 part
Taurine forms.
The present invention also provides a kind of adjusting intestinal flora, the health products of auxiliary improvement of memory comprising said combination
Object and glidant.
Further, the weight percentage of glidant is 0.1-1.5% in the health product.
Further, the weight percentage of glidant is 0.5-1.0% in the health product.
Further, the glidant is one or more in silica, calcium silicates, calcium monohydrogen phosphate.
Further, the glidant is silica.
Invention further provides it is a kind of adjusting intestinal flora, auxiliary improvement of memory health product preparation method,
Include the following steps：
1) tremella polysaccharides, galactooligosaccharide, stachyose are sieved respectively, weigh, is spare；
2) it takes docosahexaenoic acid, sialic acid, glidant and galactooligosaccharide to carry out the processing of equivalent gradient premix, must answer
Close powder 1；
3) tremella polysaccharides, stachyose, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
Further, it is described adjust intestinal flora, auxiliary improvement of memory health product preparation method, including it is following
Step：
1) tremella polysaccharides, galactooligosaccharide, stachyose, yeast extract, taurine cross 20~40 mesh screens respectively, claim
It measures, is spare；
2) docosahexaenoic acid, sialic acid, folic acid, glidant and galactooligosaccharide is taken to carry out at equivalent gradient premix
Reason, obtains composite powder 1；
3) tremella polysaccharides, stachyose, yeast extract, taurine, composite powder 1 are placed in remaining galactooligosaccharide and are mixed
In device be uniformly mixed to get.
Further, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, glidant and part galactooligosaccharide according to mass ratio 1：0.8-1.2 is mixed
It closes, obtains premixing flour 1；
2. by premixing flour 1 and galactooligosaccharide according to mass ratio 1：2-4 is mixed, and obtains premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to mass ratio 1：4-6 is mixed, and obtains premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to mass ratio 1：8-12 is mixed, and obtains premixing flour 4, i.e. composite powder 1.
Further, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, folic acid, glidant and part galactooligosaccharide according to mass ratio 1：1 is mixed
It closes, obtains premixing flour 1；
2. by premixing flour 1 and galactooligosaccharide according to mass ratio 1：3 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to mass ratio 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to mass ratio 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
The present invention also provides above-mentioned adjusting intestinal flora, improve the composition of memory in preparation treatment adjusting enterobacteriaceae
Group, auxiliary improvement of memory food in application.
Beneficial effects of the present invention：
(1) by the synergistic effect between tremella polysaccharides, galactooligosaccharide, stachyose, adjusting intestinal flora is significantly improved
Effect, while being acted on using the linkage of brain-gut axis, and be aided with DHA and sialic acid, improve memory.On the other hand, memory
Etc. nervous systems improvement, act on brain-gut axis in turn, further improve intestinal flora state, form advantageous benign follow
Ring.
(2) present invention can also add yeast extract, folic acid and taurine, and auxiliary and promotion DHA and sialic acid are sent out
The effect of waving further increases memory, and improves the effect for improving intestinal flora in turn, while the addition of yeast extract is also
Product taste can be improved, it is edible to be more suitable for consumer.
(3) present invention is carried out in preparation process using DHA, sialic acid, folic acid, glidant and part galactooligosaccharide etc.
The mode for measuring gradient premixing is more conducive to the linkage of the brain-gut axis between enhancing DHA, sialic acid, folic acid and galactooligosaccharide
Effect further increases the effect that this product adjusts intestinal flora, auxiliary improvement of memory.
Specific implementation mode
Embodiment 1 adjusts intestinal flora, the composition for improving memory and products thereof and preparation method
Composite formula：
In parts by weight, composition by 15 parts of tremella polysaccharides, 45 parts of galactooligosaccharides, 8 parts of stachyoses, 0.03 part two
Dodecahexaene acid and 0.1 part of sialic acid composition.
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose cross 20 mesh screens respectively, weigh, is spare；
2) it takes docosahexaenoic acid, sialic acid, glidant and galactooligosaccharide to carry out the processing of equivalent gradient premix, must answer
Close powder 1；
3) tremella polysaccharides, stachyose, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, glidant and part galactooligosaccharide according to 1：1 mixing, is premixed
Powder 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is silica, and the weight percentage that glidant in product is made is 0.1%.
Embodiment 2 adjusts intestinal flora, the composition for improving memory and products thereof and preparation method
Composite formula：
In parts by weight, composition by 23 parts of tremella polysaccharides, 25 parts of galactooligosaccharides, 15 parts of stachyoses, 0.03 part
Docosahexaenoic acid, 0.08 part of sialic acid and 4 parts of yeast extract compositions.
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose, yeast extract cross 30 mesh screens respectively, weigh, is spare；
2) it takes docosahexaenoic acid, sialic acid, glidant and galactooligosaccharide to carry out the processing of equivalent gradient premix, must answer
Close powder 1；
3) tremella polysaccharides, stachyose, composite powder 1, yeast extract are placed in mixer with remaining galactooligosaccharide and are mixed
Close uniformly to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, glidant and part galactooligosaccharide according to 1：1 mixing, is premixed
Powder 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is calcium monohydrogen phosphate, and the weight percentage that glidant in product is made is 0.1%.
Embodiment 3 adjusts intestinal flora, the composition for improving memory and products thereof and preparation method
Composite formula：
In parts by weight, composition by 20 parts of tremella polysaccharides, 40 parts of galactooligosaccharides, 10 parts of stachyoses, 0.02 part
Docosahexaenoic acid, 0.04 part of sialic acid, 6 parts of yeast extracts, 0.0004 part of folic acid and 0.12 part of taurine composition.
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose, yeast extract, taurine cross 30 mesh screens respectively, weigh, is standby
With；
2) docosahexaenoic acid, sialic acid, folic acid, glidant and galactooligosaccharide is taken to carry out at equivalent gradient premix
Reason, obtains composite powder 1；
3) tremella polysaccharides, stachyose, yeast extract, taurine, composite powder 1 are placed in remaining galactooligosaccharide and are mixed
In device be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, folic acid, glidant and part galactooligosaccharide according to 1：1 mixing, obtains
Premixing flour 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：3 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 0.73%.
Embodiment 4 adjusts intestinal flora, the composition for improving memory and products thereof and preparation method
Composite formula：
In parts by weight, composition by 20 parts of tremella polysaccharides, 40 parts of galactooligosaccharides, 10 parts of stachyoses, 0.02 part
Docosahexaenoic acid and 0.04 part of sialic acid composition.Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose cross 30 mesh screens respectively, weigh, is spare；
2) it takes docosahexaenoic acid, sialic acid, glidant and galactooligosaccharide to carry out the processing of equivalent gradient premix, must answer
Close powder 1；
3) tremella polysaccharides, stachyose, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, glidant and part galactooligosaccharide according to 1：0.8 mixing, obtains pre-
Mixed powder 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：2 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：4 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：8 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 0.51%.
Embodiment 5 adjusts intestinal flora, the composition for improving memory and products thereof and preparation method
Composite formula：
In parts by weight, composition by 25 parts of tremella polysaccharides, 20 parts of galactooligosaccharides, 13 parts of stachyoses, 0.005 part
Docosahexaenoic acid, 0.02 part of sialic acid, 2 parts of yeast extracts, 0.0001 part of folic acid and 0.11 part of taurine composition.
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose, yeast extract, taurine cross 40 mesh screens respectively, weigh, is standby
With；
2) docosahexaenoic acid, sialic acid, folic acid, glidant and galactooligosaccharide is taken to carry out at equivalent gradient premix
Reason, obtains composite powder 1；
3) tremella polysaccharides, stachyose, yeast extract, taurine, composite powder 1 are placed in remaining galactooligosaccharide and are mixed
In device be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, folic acid, glidant and part galactooligosaccharide according to 1：1.2 mixing, obtain
To premixing flour 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：4 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：6 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：12 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant calcium monohydrogen phosphate, the weight percentage that glidant in product is made are 1.0%.
Embodiment 6 adjusts intestinal flora, the composition for improving memory and products thereof and preparation method
Composite formula：
In parts by weight, composition by 18 parts of tremella polysaccharides, 25 parts of galactooligosaccharides, 12 parts of stachyoses, 0.01 part
Docosahexaenoic acid, 0.05 part of sialic acid, 8.5 parts of yeast extracts, 0.0005 part of folic acid and 0.14 part of taurine composition.Production
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose, yeast extract, taurine cross 30 mesh screens respectively, weigh, is standby
With；
2) docosahexaenoic acid, sialic acid, folic acid, glidant and galactooligosaccharide is taken to carry out at equivalent gradient premix
Reason, obtains composite powder 1；
3) tremella polysaccharides, stachyose, yeast extract, taurine, composite powder 1 are placed in remaining galactooligosaccharide and are mixed
In device be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, folic acid, glidant and part galactooligosaccharide according to 1：1 mixing, obtains
Premixing flour 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：3 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is silica, and the weight percentage that glidant in product is made is 0.3%.
The composition for adjusting intestinal flora, improving memory of comparative example 1 without containing tremella polysaccharides and products thereof and preparation
Method
Composite formula：
In addition to without containing tremella polysaccharides, remaining is the same as embodiment 4.
Product preparation method：
1) galactooligosaccharide, stachyose cross 30 mesh screens respectively, weigh, is spare；
2) it takes docosahexaenoic acid, sialic acid, glidant and galactooligosaccharide to carry out the processing of equivalent gradient premix, must answer
Close powder 1；
3) stachyose, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, glidant and part galactooligosaccharide according to 1：1 mixing, is premixed
Powder 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：3 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 0.88%.
The composition for adjusting intestinal flora, improving memory of comparative example 2 without containing galactooligosaccharide and products thereof and system
Preparation Method
Composite formula：
In addition to without containing galactooligosaccharide, remaining is the same as embodiment 3.
Product preparation method：
1) tremella polysaccharides, stachyose cross 30 mesh screens respectively, weigh, is spare；
2) docosahexaenoic acid, sialic acid, the processing of glidant premix are taken, composite powder 1 is obtained；
3) tremella polysaccharides, stachyose, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 1.05%.
The composition for adjusting intestinal flora, improving memory of comparative example 3 without containing stachyose and products thereof and preparation side
Method
Composite formula：
In addition to without containing stachyose, remaining is the same as embodiment 3.
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide cross 30 mesh screens respectively, weigh, is spare；
2) it takes docosahexaenoic acid, sialic acid, glidant and galactooligosaccharide to carry out the processing of equivalent gradient premix, must answer
Close powder 1；
3) tremella polysaccharides, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by docosahexaenoic acid, sialic acid, glidant and part galactooligosaccharide according to 1：1 mixing, is premixed
Powder 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：3 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 0.95%.
The composition for adjusting intestinal flora, improving memory of comparative example 4 without containing DHA and sialic acid and products thereof and system
Preparation Method
Composite formula：
In addition to without containing DHA and sialic acid, remaining is the same as embodiment 3.
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose cross 30 mesh screens respectively, weigh, is spare；
2) it takes glidant to carry out the processing of equivalent gradient premix with galactooligosaccharide, obtains composite powder 1；
3) tremella polysaccharides, stachyose, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
Wherein, the step of step 2) moderate gradient premix processing is：
1. by glidant and part galactooligosaccharide according to 1：1 mixing, obtains premixing flour 1；
2. by premixing flour 1 and galactooligosaccharide according to 1：3 mixing, obtain premixing flour 2；
3. by premixing flour 2 and galactooligosaccharide according to 1：5 mixing, obtain premixing flour 3；
4. by premixing flour 3 and galactooligosaccharide according to 1：10 mixing, obtain premixing flour 4, i.e. composite powder 1.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 0.80%.
The group that adjusts intestinal flora, improve memory of the comparative example 5 without containing tremella polysaccharides, galactooligosaccharide and stachyose
Close object and products thereof and preparation method
Composite formula：
In addition to without containing tremella polysaccharides, galactooligosaccharide and stachyose, remaining is the same as embodiment 3.
Product preparation method：
Take docosahexaenoic acid, sialic acid, glidant be placed in mixer be uniformly mixed to get.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 1.65%.
Unreasonable composition for adjusting intestinal flora, improving memory of 6 constituent content of comparative example and products thereof and preparation
Method
Composite formula：
In parts by weight, composition by 30 parts of tremella polysaccharides, 18 parts of galactooligosaccharides, 5 parts of stachyoses, 0.05 part two
Dodecahexaene acid and 0.01 part of sialic acid composition.
Product preparation method：With embodiment 3.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 0.80%
Comparative example 7 do not use composition and products thereof for adjusting intestinal flora, improving memory prepared by premixing method with
Preparation method
Composite formula：With embodiment 3.
Product preparation method：
1) tremella polysaccharides, galactooligosaccharide, stachyose cross 30 mesh screens respectively, weigh, is spare；
2) docosahexaenoic acid, sialic acid, glidant, tremella polysaccharides, stachyose, galactooligosaccharide is taken to be placed in mixer
In be uniformly mixed to get.
Wherein, glidant is calcium carbonate, and the weight percentage that glidant in product is made is 0.73%.
7 product of the present invention of embodiment adjusts intestinal flora Effect study
Specific experiment process and evaluation criterion reference《Health food is examined and assessment technique specification》In (version in 2003)
A part 24. adjusts intestinal flora function.
7.1 zoopery
Experimental animal uses 18-22g mouse, male, every group 10.Given the test agent is 1-6 of the embodiment of the present invention, comparative example
1-7, given the test agent dosage be 0.33g/ (kgd), given the test agent give the time be 14 days, it is as a result specific as follows.
1 product of the present invention of table adjusts mouse intestinal flora exercising result
Note：Respectively arrange it is different letter between have significant difference (P<0.05).
Best results of the embodiment 3 provided by the invention in terms of adjusting mouse intestinal flora；Formula in embodiment 4 lacks
Few yeast extract, folic acid and taurine, effect is opposite compared with embodiment 3 to be weakened, and illustrates that three kinds of ingredients can be further
Promote effect of the product of the present invention in terms of adjusting intestinal flora.Based on embodiment 3, lacks any of which, all can
The effect for adjusting intestinal flora is substantially reduced, fully demonstrates the synergy between each component, while lacking DHA, sialic acid
In the case of, due to having lacked the correlation between brain-gut axis, function and effect are also had a greatly reduced quality.
7.2 clinical trial
Subject according to《Health food is examined and assessment technique specification》First part 24. adjusts enteron aisle in (version in 2003)
It requires to be selected in flora function, every group of 60 people.Given the test agent is 1-6 of the embodiment of the present invention, comparative example 1-7, given the test agent
Dosage be 0.033g/ (kgd), given the test agent give the time be 14 days, it is as a result specific as follows.
2 product clinical application effect of the present invention of table
Note：Respectively arrange it is different letter between have significant difference (P<0.05).
During experiment, subject's state of mind, sleep quality, diet, stool and urine, blood pressure etc. do not occur it is apparent it is abnormal,
Blood urine, feces routine inspection is normal, and hepatic and renal function, Chest X-rays, electrocardiogram, abdominal B-scan ultrasonography inspection are normal before testing.
It is found by adjusting intestinal flora Function detection to given the test agent, preferred embodiment provided by the invention, embodiment 3 exists
Adjust the best results in terms of intestinal flora；Compared with Example 3, the formula in embodiment 4 lack yeast extract, folic acid with
And taurine, illustrate that three kinds of ingredients can further promote effect of the product of the present invention in terms of adjusting intestinal flora.In reality
It applies in the core formulation in example 3, lacks any of which, can all substantially reduce the effect for adjusting intestinal flora, fully prove
Synergy between each component, while in the case where lacking DHA, sialic acid, it is mutual between brain-gut axis due to having lacked
Relationship, function and effect are also had a greatly reduced quality.
8 product of the present invention of embodiment improves memory Effect study
Specific experiment process and evaluation criterion reference《Health food is examined and assessment technique specification》In (version in 2003)
Zoopery in a part of 5. auxiliary improving memory functions.Wherein given the test agent be 1-6 of the embodiment of the present invention, comparative example 1-7,
Dosage is 0.33g/ (kgd), and experimental period 30 days is as a result as follows.
3 mouse Jumping test result of table
Note：Respectively arrange it is different letter between have significant difference (P<0.05).
4 mouse step-through test result of table
Note：Respectively arrange it is different letter between have significant difference (P<0.05).
5 Mice water maze of table is tested
Note：Respectively arrange it is different letter between have significant difference (P<0.05).
By mouse Jumping test, step-through test, water maze laboratory, fully prove product of the present invention in auxiliary improvement of memory
Aspect has preferable effect, and there are good coordinative roles between each component in product, and lacking any of which can be notable
Its effect is reduced, especially by the relationship between brain-gut axis, intestines are adjusted using tremella polysaccharides, galactooligosaccharide, stachyose
Road flora can not only influence intestinal health, but also can influence central nervous system, enhance DHA, sialic acid improves note
The effect recalled has obtained good effect.
Above-mentioned detailed description is illustrating for one of them possible embodiments of the present invention, the embodiment not to
The scope of the claims of the present invention is limited, all equivalence enforcements or change without departing from carried out by the present invention are intended to be limited solely by the technology of the present invention
In the range of scheme.
Claims (10)
1. a kind of composition adjusting intestinal flora, auxiliary improvement of memory, which is characterized in that the composition includes that white fungus is more
Sugar, galactooligosaccharide, stachyose, docosahexaenoic acid and sialic acid.
2. the composition according to claim 1 for adjusting intestinal flora, auxiliary improvement of memory, which is characterized in that described group
Close object in parts by weight, including 15-25 parts of tremella polysaccharides, 20-45 parts of galactooligosaccharides, 8-15 parts of stachyoses, 0.005-
0.03 part of docosahexaenoic acid and 0.02-0.1 parts of sialic acids.
3. the composition according to claim 1 for adjusting intestinal flora, auxiliary improvement of memory, which is characterized in that described group
It further includes one or more in yeast extract, folic acid and taurine to close object.
4. the composition according to claim 3 for adjusting intestinal flora, auxiliary improvement of memory, which is characterized in that described group
It closes object in parts by weight, further includes 2-8.5 parts of yeast extracts, 0.0001-0.0005 parts of folic acid and 0.11-0.14 portions of oxen
It is one or more in sulfonic acid.
5. a kind of health product adjusting intestinal flora, auxiliary improvement of memory, which is characterized in that the health product includes right
It is required that any one of 1-4 compositions and glidant.
6. the health product according to claim 5 for adjusting intestinal flora, auxiliary improvement of memory, which is characterized in that described
The weight percentage of glidant is 0.1-1.5% in health product.
7. the health product according to claim 5 for adjusting intestinal flora, auxiliary improvement of memory, which is characterized in that described
Glidant is one or more in silica, calcium silicates, calcium monohydrogen phosphate.
8. the preparation method of the health product of claim 5-7 any one of them adjusting intestinal flora, auxiliary improvement of memory, packet
Include following steps：
1) tremella polysaccharides, galactooligosaccharide, stachyose are sieved respectively, weigh, is spare；
2) it takes docosahexaenoic acid, sialic acid, glidant and galactooligosaccharide to carry out the processing of equivalent gradient premix, obtains composite powder
1；
3) tremella polysaccharides, stachyose, composite powder 1 are placed in remaining galactooligosaccharide in mixer be uniformly mixed to get.
9. the preparation method of the health product of adjusting intestinal flora according to claim 8, auxiliary improvement of memory, feature
It is, step 2) the moderate gradient premixes the step of handling and is：
1. by docosahexaenoic acid, sialic acid, glidant and part galactooligosaccharide according to mass ratio be 1：0.8-1.2 is mixed
It closes, obtains premixing flour 1；
2. according to mass ratio being 1 by premixing flour 1 and galactooligosaccharide：2-4 is mixed, and obtains premixing flour 2；
3. according to mass ratio being 1 by premixing flour 2 and galactooligosaccharide：4-6 is mixed, and obtains premixing flour 3；
4. according to mass ratio being 1 by premixing flour 3 and galactooligosaccharide：8-12 is mixed, and obtains premixing flour 4, i.e. composite powder 1.
10. any one of claim 1-4 compositions answering in preparing the health product for adjusting intestinal flora, auxiliary improvement of memory
With.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810658100.1A CN108741042A (en) | 2018-06-25 | 2018-06-25 | It is a kind of to adjust intestinal flora, composition that improvement is remembered and products thereof and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN113397080A (en) * | 2021-07-09 | 2021-09-17 | 中科鸿基生物科技有限公司 | Sialic acid solid beverage and preparation method thereof |
| CN113855587A (en) * | 2021-09-06 | 2021-12-31 | 武汉中科光谷绿色生物技术有限公司 | Composition for inhibiting Maillard reaction and application thereof |
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| CN105724584A (en) * | 2016-03-14 | 2016-07-06 | 上海晨冠乳业有限公司 | Infant formula milk powder with prebiotics and probiotics and method for preparing infant formula milk powder |
| CN106255505A (en) * | 2014-04-25 | 2016-12-21 | Mjn 美国控股有限责任公司 | There is the formulation compositions of human milk oligosaccharides, prebiotics and probiotic bacteria |
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| CN105166629A (en) * | 2015-10-27 | 2015-12-23 | 江西美庐乳业集团有限公司 | Nutritional steamed bun assisted in improving memory of students and promoting attention |
| CN105724584A (en) * | 2016-03-14 | 2016-07-06 | 上海晨冠乳业有限公司 | Infant formula milk powder with prebiotics and probiotics and method for preparing infant formula milk powder |
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| CN113397080A (en) * | 2021-07-09 | 2021-09-17 | 中科鸿基生物科技有限公司 | Sialic acid solid beverage and preparation method thereof |
| CN113855587A (en) * | 2021-09-06 | 2021-12-31 | 武汉中科光谷绿色生物技术有限公司 | Composition for inhibiting Maillard reaction and application thereof |
| CN113855587B (en) * | 2021-09-06 | 2023-11-24 | 武汉中科光谷绿色生物技术有限公司 | Composition for inhibiting Maillard reaction and application thereof |
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