CN108721442A - Treat Chinese medicine composition, the preparation and preparation method thereof of burn and scald and diaper dermatitis - Google Patents
Treat Chinese medicine composition, the preparation and preparation method thereof of burn and scald and diaper dermatitis Download PDFInfo
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Abstract
The invention discloses treatment burn and scald and Chinese medicine composition, preparation and the preparation methods of diaper dermatitis, and Chinese medicine composition includes the component of following parts by weight:2-4 parts of 11-12 parts of Asian puccoon, 11-12 parts of radix scutellariae, 11-12 parts of Cortex Phellodendri, 11-12 parts of rheum officinale, 5-8 parts of garden burnet, 11-12 parts of folium isatidis, 4-6 parts of radix paeoniae rubra, 4-6 parts of the root bark of tree peony, 4-6 parts of Radix Angelicae Sinensis and safflower, use the preparation that the composition is produced for finish, paste or gelling agent.The Chinese medicine preparation that Chinese medicine composition and preparation method through the invention is prepared has good curative effect for the treatment of slight burn and scald, shortcoming of the existing Chinese medicine preparation in burn and scald in therapy can be made up, and said preparation can prevent the secondary infection of pediatric diaper dermatitis, shorten treatment time.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of Chinese traditional medicine composition for treating burn and scald and diaper dermatitis
Object, preparation and preparation method thereof.
Background technology
Burn and scald is generally referred to by heating power (including hydrothermal solution, steam, high-temperature gas, flame, electric energy, chemical substance, radiation
Line, scorching hot metal liquid or solid etc.) act on a kind of extremely complex dermal tissue insult disease caused by body.By
In the temperature and time of contact difference of heating power, the degeneration necrosis of skin different levels or depth can be caused.With living standard
Raising and the continuous expansion in social life space, burned patient number is in ascendant trend year by year.In China, every year there are about
20000000 people are burnt in various degree, account for the 1.5%~2.0% of total population, and wherein number of hospitalized accounts for 5.0%.Currently, chemical
Drug such as antibacterials, silver salt etc. mainly treats burn and scald by modes such as anti-inflammatory, antibacterial, analgesias, and there are certain bad
Reaction, etc. undesirable to Regenerated energy force difference, the consumer edema effect for the treatment of burnt degree of the surface of a wound promotion skin tissue of deep burn
It is insufficient;And Chinese medicine in terms of wound healing it is now recognized that have obvious characteristic and advantage.
It is unique that Traditional Chinese Medicine recognizes the interpretation of the cause, onset and process of an illness of burn and scald, often with the burning hot evil cause of disease for burn and scald of poison, is restrained with bitter cold
For the rules for the treatment of, therefore multi-purpose antipyretic and antidotal type Chinese medicine;Qing Dynasty's Chen Shiduo exists《Qingnang Mijue》In emphasize " soup scald sore ... it is light then evil in skin
Skin, heavy then evil are more particularly done harm in internal organs, therefore control the disease for baked wheaten cakes in muscle, it is necessary to inside and outside to control together, then fiery poison legibility ".In various
Medicine Modern preparations are especially the preparation containing Asian puccoon and occupy a tiny space in the mild treatment of burn and scald, and curative effect is affirmed.It is existing
In generation, is studies have shown that the mechanism of action of the anti-burn and scald of Chinese medicine is secreted and discharged with promotion tissue growth factor, reduces inflammation and react, adjust
It is related to control synthesis and metabolism, promotion epithelial cell proliferation, scavenging activated oxygen of collagen etc..Part modern study more traditional Chinese medicine
The clinical application for the treatment of burn and scald provides theoretical foundation.The existing polygamy of Chinese medicine composition containing Asian puccoon 5 reported for work is with radix scutellariae, Huang
One or more medicinal materials such as cypress, borneol, garden burnet, Radix Angelicae Sinensis lay particular emphasis on clearing heat and cooling blood, eliminating dampness removing toxic substances, and from the aspect of controlling inside not
Enough comprehensive, evil outgoing, cooling and activating blood ability still is apparent not enough thoroughly.
On the other hand, diaper dermatitis (diaper dermatitis, DD) is also known as red stern, diaper rash, is newborn and baby
Infancy common damage dermatoses.The incidence of domestic and international newborn DD is 14.1%~35.1%, jaundice infant phototherapy
Period DD incidence is up to 46.8%, and the DD infants for being associated with bacterium or fungal infection are up to 92.4%.Currently, prevention is small
Youngster DD and its secondary infection shorten treatment time, are still one of community and pediatric ward stubborn problem.
Invention content
For above-mentioned deficiency in the prior art, the present invention provides a kind of Chinese medicine groups for treating burn and scald and diaper dermatitis
Object, preparation and preparation method thereof are closed, the Chinese medicine preparation that Chinese medicine composition and preparation method through the invention are prepared is for light
The treatment for spending burn and scald has good curative effect, can make up shortcoming of the existing Chinese medicine preparation in burn and scald in therapy, and
Said preparation can prevent the secondary infection of pediatric diaper dermatitis, shorten treatment time.
To achieve the above object, the technical solution adopted by the present invention to solve the technical problems is:
Burn and scald and the Chinese medicine composition of diaper dermatitis are treated, the component of following parts by weight is included:4-67 parts of Asian puccoon, radix scutellariae
4-67 parts, 4-67 parts of Cortex Phellodendri, 4-67 parts of rheum officinale, 4-67 parts of garden burnet, 4-67 parts of folium isatidis, 4-67 parts of radix paeoniae rubra, 4-67 parts of the root bark of tree peony, when
Return 4-67 parts and 4-67 parts of safflower.
Further, include the component of following parts by weight:It is 11-12 parts of Asian puccoon, 11-12 parts of radix scutellariae, 11-12 parts of Cortex Phellodendri, big
2-4 parts of 11-12 parts yellow, 5-8 parts of garden burnet, 11-12 parts of folium isatidis, 4-6 parts of radix paeoniae rubra, 4-6 parts of the root bark of tree peony, 4-6 parts of Radix Angelicae Sinensis and safflower.
Further, include the component of following parts by weight:10 parts of Asian puccoon, 10 parts of radix scutellariae, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale,
2.4 parts of 6.6 parts of elm, 10 parts of folium isatidis, 5 parts of radix paeoniae rubra, 5 parts of the root bark of tree peony, 5 parts of Radix Angelicae Sinensis and safflower.
Treat burn and scald and the Chinese medicine preparation of diaper dermatitis, including above-mentioned Chinese medicine composition and auxiliary material, and the Chinese medicine system
Agent is finish, paste or gelling agent.
Further, when preparation is finish, auxiliary material used and its with the weight ratio of Chinese medicine composition it is:Sesame oil:Chinese medicine group
Conjunction object is 4-5:1.
Further, when preparation is paste, auxiliary material used and its with the weight ratio of Chinese medicine composition it is:Vaseline:Chinese medicine
Composition is 3-4:1.
Further, when preparation is gelling agent, auxiliary material used and its with the weight ratio of Chinese medicine composition it is:Carbomer:Chinese holly
Rafter acid:Glycerine:Tween-80:Chinese medicine composition is 0.1-0.2:0.05-0.2:0.1-0.3:0.1-0.3:1.
Further, the preparation method for treating burn and scald and the Chinese medicine preparation of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 110-125 DEG C, 8-13 minutes is kept the temperature, is then cooled to 50-70 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
It is heated to 100-120 DEG C, fries, filtering withered and yellow to medicinal material, then the removing dregs of a decoction are cooled to 50-70 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 100-120 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and finish is made.
Further, the preparation method for treating burn and scald and the Chinese medicine preparation of diaper dermatitis, includes the following steps:
(1) absolute ethyl alcohol of 3-4 times of medicinal material weight is added into Asian puccoon, impregnates 5-8 hours, 3-4 is extracted at 70-80 DEG C
Hour, filtering obtains the first extracting solution and filter residue, and the water of 3-4 times of filter residue weight is added into filter residue, 2-3 is extracted at 70-80 DEG C
Hour, filtering obtains the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and the Asian puccoon that relative density is 1.05-1.25 is made
Extract;
(2) radix scutellariae, Cortex Phellodendri, rheum officinale, garden burnet, radix paeoniae rubra, the root bark of tree peony and Radix Angelicae Sinensis are mixed, 3-4 times of medicinal material is added into mixture
The water of weight is impregnated 5-8 hours, is extracted 3-4 hours at 90-100 DEG C, is filtered, is obtained the first extracting solution and filter residue, then will be big
Leafiness and safflower are added in filter residue, and the water of 3-4 times of filter residue mixture weight is added into filter residue mixture, is carried at 90-100 DEG C
It takes 2-3 hours, filters, obtain the second extracting solution, merge extracting solution twice, be concentrated under reduced pressure, it is 1.05-1.25's that relative density, which is made,
Clear cream;
(3) vaseline is added to the container, big fire is heated 3-6 minutes;
(4) Radix Arnebiae extract obtained by step (1) and the Chinese medicine clear cream obtained by step (2) are added to all scholars of step (3)
In woods solution, slow boiling boils 15-30 minutes, is stirred continuously simultaneously, filters out residue, dries in the air cool, dispenses, and paste is made.
Further, the preparation method for treating burn and scald and the Chinese medicine preparation of diaper dermatitis, includes the following steps:
(1) absolute ethyl alcohol of 3-4 times of medicinal material weight is added into Asian puccoon, impregnates 5-8 hours, 3-4 is extracted at 70-80 DEG C
Hour, filtering obtains the first extracting solution and filter residue, and the water of 3-4 times of filter residue weight is added into filter residue, 2-3 is extracted at 70-80 DEG C
Hour, filtering obtains the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and the Asian puccoon that relative density is 1.05-1.25 is made
Extract;
(2) radix scutellariae, Cortex Phellodendri, rheum officinale, garden burnet, radix paeoniae rubra, the root bark of tree peony and Radix Angelicae Sinensis are mixed, 3-4 times of medicinal material is added into mixture
The water of weight is impregnated 5-8 hours, is extracted 3-4 hours at 90-100 DEG C, is filtered, the first extracting solution and filter residue is obtained, by folium isatidis
It is added in filter residue with safflower, the water of 3-4 times of filter residue mixture weight is added into filter residue mixture, 2- is extracted at 90-100 DEG C
3 hours, filtering obtained the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and it is the clear of 1.05-1.25 that relative density, which is made,
Cream;
(3) purified water is added into carbomer, fully after swelling, glycerine, citric acid and Tween-80, stirring is added
Uniformly, gel forming agent is obtained;
(4) Radix Arnebiae extract obtained by step (1) and the Chinese medicine clear cream obtained by step (2) are added obtained by step (3)
It in gel shaped dose, stirs evenly, dispenses, gelling agent is made.
Beneficial effects of the present invention are specific as follows:
1, present invention selection Asian puccoon, radix scutellariae, Cortex Phellodendri, rheum officinale, garden burnet, folium isatidis, radix paeoniae rubra, the root bark of tree peony, Radix Angelicae Sinensis, safflower carry out group
It closes, for slight burn and scald, baby diaper disease.Such patient is mostly qi and blood excess heat, stagnation of QI-blood, some patients with exudation
Easily there is the characteristics of impairment of yin hematozemia moves blood in liquid, pain, excess heat event.With Asian puccoon, rheum officinale, radix scutellariae three altogether for monarch drug in a prescription in side, Asian puccoon
Cooling and activating blood, removing toxic substances ecchymose removing are used by ancient Chinese medicine doctor, rheum officinale promoting blood circulation and cooling blood, clearing heat and detoxicating, swelling and pain relieving, and hemostasis dehumidifying is received
It holds back.Asian puccoon and rheum officinale collective effect are in ying blood point;Radix scutellariae is clearing heat and detoxicating, eliminating dampness acts on qi leel, inducing Ying heat into Qi phase still all right of joining the army.Cause
Three taste synergy can make qi leel pyrolysis, blood system heat disappear on this, extravasated blood, bleeding stops, pain subtracts, oozes out less, ulceration holds back mouth.
2, Cortex Phellodendri, folium isatidis, radix paeoniae rubra, the root bark of tree peony and garden burnet are ministerial drug altogether, and Cortex Phellodendri, folium isatidis can assist radix scutellariae enhancing to qi leel
The removing summer-heat effect of heat, is more favorable for saturating hair of the blood system heat to qi leel;Radix paeoniae rubra, root bark of tree peony cooling and activating blood, assist the cooling and activating blood of Asian puccoon
Effect;Garden burnet assists rheum officinale, enhancing swelling and pain relieving, removing toxic substances, promoting blood circulation and cooling blood, convergent effect.
3, Radix Angelicae Sinensis and safflower are jointly adjuvant, and safflower activates blood circulation and disperses blood clots and nature and flavor partial temperature, matches in large dosage of group's medicine of a cold nature
5, not only enhanced promoting blood circulation effect, and but also can prevent the ice caused by a large amount of medicine of a cold natures from lying prostrate, and had been unlikely to that qi and blood is cool to be held back;Chinese angelica blood supplementing is invigorated blood circulation, can
Enhance promoting blood circulation effect, and the anti-stagnant ice volt of energy, while supplementing hematozemia caused by excess heat, more conducively blood operation is unobstructed, is conducive to disease
The recovery of disease.
4, three kinds of dosage forms can be produced as in preparation of the invention to be produced as not to meet the needs of different crowd is to dosage form
With dosage form when, therapeutic effect is identical.
Specific implementation mode
Embodiment 1
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:4 parts of Asian puccoon, 4 parts of radix scutellariae,
160 parts of 4 parts of Cortex Phellodendri, 4 parts of rheum officinale, 4 parts of garden burnet, 4 parts of folium isatidis, 4 parts of radix paeoniae rubra, 4 parts of the root bark of tree peony, 4 parts of Radix Angelicae Sinensis, 4 parts of safflower and sesame oil.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 110 DEG C, 8 minutes is kept the temperature, is then cooled to 50 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
100 DEG C are heated to, filtering withered and yellow to medicinal material is fried, then the removing dregs of a decoction are cooled to 50 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 100 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Embodiment 2
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:12 parts of Asian puccoon, radix scutellariae 12
Part, 12 parts of Cortex Phellodendri, 12 parts of rheum officinale, 12 parts of garden burnet, 12 parts of folium isatidis, 12 parts of radix paeoniae rubra, 12 parts of the root bark of tree peony, 12 parts of Radix Angelicae Sinensis, 12 parts of safflower
With 600 parts of sesame oil.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 115 DEG C, 10 minutes is kept the temperature, is then cooled to 55 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
110 DEG C are heated to, filtering withered and yellow to medicinal material is fried, then the removing dregs of a decoction are cooled to 50 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 110 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Embodiment 3
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:10 parts of Asian puccoon, radix scutellariae 10
Part, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale, 6.6 parts of garden burnet, 10 parts of folium isatidis, 5 parts of radix paeoniae rubra, 5 parts of the root bark of tree peony, 5 parts of Radix Angelicae Sinensis, 2.4 parts of safflower and
355 parts of sesame oil.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 118 DEG C, 12 minutes is kept the temperature, is then cooled to 60 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
110 DEG C are heated to, filtering withered and yellow to medicinal material is fried, then the removing dregs of a decoction are cooled to 60 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 110 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Embodiment 4
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:67 parts of Asian puccoon, radix scutellariae 67
Part, 67 parts of Cortex Phellodendri, 67 parts of rheum officinale, 67 parts of garden burnet, 67 parts of folium isatidis, 67 parts of radix paeoniae rubra, 67 parts of the root bark of tree peony, 67 parts of Radix Angelicae Sinensis, 67 parts of safflower
With 2680 parts of sesame oil.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 125 DEG C, 13 minutes is kept the temperature, is then cooled to 70 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
120 DEG C are heated to, filtering withered and yellow to medicinal material is fried, then the removing dregs of a decoction are cooled to 70 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 120 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Embodiment 5
Burn and scald and the Chinese medicinal ointment of diaper dermatitis are treated, the component of following parts by weight is included:10 parts of Asian puccoon, radix scutellariae 10
Part, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale, 6.6 parts of garden burnet, 10 parts of folium isatidis, 5 parts of radix paeoniae rubra, 5 parts of the root bark of tree peony, 5 parts of Radix Angelicae Sinensis, 2.4 parts of safflower and
269 parts of vaseline.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicinal ointment of diaper dermatitis, includes the following steps:
(1) absolute ethyl alcohol of 4 times of medicinal material weight is added to Asian puccoon, impregnates 8 hours, when extracting 3 at 80 DEG C, filtering obtains
The water of 4 times of filter residue weight is added into filter residue, is extracted 3 hours at 80 DEG C for first extracting solution and filter residue, filters, obtains second and carry
Liquid is taken, extracting solution twice is merged, is concentrated under reduced pressure, the Radix Arnebiae extract that relative density is 1.25 is made;
(2) radix scutellariae, Cortex Phellodendri, rheum officinale, garden burnet, radix paeoniae rubra, the root bark of tree peony and Radix Angelicae Sinensis are mixed, 4 times of medicinal material weights is added into mixture
The water of amount is impregnated 8 hours, is extracted 4 hours at 100 DEG C, is filtered, is obtained the first extracting solution and filter residue, folium isatidis and safflower are added
Enter in filter residue, the water of 4 times of filter residue mixture weights is added into filter residue mixture, extract 3 hours at 100 DEG C, filtering obtains the
Two extracting solutions merge extracting solution twice, are concentrated under reduced pressure, and the clear cream that relative density is 1.15 is made;
(3) vaseline is added to the container, big fire is heated 4 minutes;
(4) Radix Arnebiae extract obtained by step (1) and the Chinese medicine clear cream obtained by step (2) are added to all scholars of step (3)
In woods solution, slow boiling boils 20 minutes, is stirred continuously simultaneously, filters out residue, dries in the air cool, dispenses, and paste is made.
Embodiment 6
The traditional Chinese medicine gel for treating burn and scald and diaper dermatitis, includes the component of following parts by weight:10 parts of Asian puccoon, radix scutellariae 10
Part, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale, 6.6 parts of garden burnet, 10 parts of folium isatidis, 5 parts of radix paeoniae rubra, 5 parts of the root bark of tree peony, 5 parts of Radix Angelicae Sinensis, 2.4 parts of safflower,
11.1 parts of 11 parts of carbomer, 7.4 parts of citric acid, 14.8 parts of glycerine and Tween-80.
The preparation method of the traditional Chinese medicine gel of above-mentioned treatment burn and scald and diaper dermatitis, includes the following steps:
(1) absolute ethyl alcohol of 4 times of medicinal material weight is added to Asian puccoon, impregnates 8 hours, is extracted 4 hours at 70-80 DEG C, mistake
Filter, obtains the first extracting solution and filter residue, and the absolute ethyl alcohol of 4 times of filter residue weight is added into filter residue, is extracted 3 hours at 70-80 DEG C,
Filtering obtains the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and the Radix Arnebiae extract that relative density is 1.25 is made;
(2) radix scutellariae, Cortex Phellodendri, rheum officinale, garden burnet, radix paeoniae rubra, the root bark of tree peony and Radix Angelicae Sinensis are mixed, 4 times of medicinal material weights is added into mixture
The water of amount is impregnated 8 hours, is extracted 4 hours at 100 DEG C, is filtered, is obtained the first extracting solution and filter residue, folium isatidis and safflower are added
Enter in filter residue, the water of 3-4 times of filter residue mixture weight is added into filter residue mixture, is extracted 3 hours at 100 DEG C, filters, obtain
Second extracting solution merges extracting solution twice, is concentrated under reduced pressure, and the clear cream that relative density is 1.15 is made;
(3) purified water is added into carbomer, fully after swelling, glycerine, citric acid and Tween-80, stirring is added
Uniformly, gel forming agent is obtained;
(4) Radix Arnebiae extract obtained by step (1) and the Chinese medicine clear cream obtained by step (2) are added obtained by step (3)
It in gel shaped dose, stirs evenly, dispenses, gelling agent is made.
Comparative example 1
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:10 parts of Asian puccoon, radix scutellariae 10
Part, 10 parts of Cortex Phellodendri, 6.6 parts of garden burnet, 10 parts of folium isatidis, 5 parts of radix paeoniae rubra, 5 parts of the root bark of tree peony, 5 parts of Radix Angelicae Sinensis, 2.4 parts of safflower and sesame oil 355
Part.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 118 DEG C, 12 minutes is kept the temperature, is then cooled to 60 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
110 DEG C are heated to, filtering withered and yellow to medicinal material is fried, then the removing dregs of a decoction are cooled to 60 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 110 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Comparative example 2
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:10 parts of Asian puccoon, radix scutellariae 10
355 parts of part, 10 parts of rheum officinale, 6.6 parts of garden burnet, 5 parts of radix paeoniae rubra, 5 parts of the root bark of tree peony, 5 parts of Radix Angelicae Sinensis, 2.4 parts of safflower and sesame oil.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 118 DEG C, 12 minutes is kept the temperature, is then cooled to 60 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower is added in the sesame oil obtained by step (1), slow heating rises
Temperature fries, filtering withered and yellow to medicinal material to 110 DEG C, then the removing dregs of a decoction are cooled to 60 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon and safflower, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 110 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Comparative example 3
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:10 parts of Asian puccoon, radix scutellariae 10
355 parts of part, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale, 6.6 parts of garden burnet, 10 parts of folium isatidis, 5 parts of Radix Angelicae Sinensis, 2.4 parts of safflower and sesame oil.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 118 DEG C, 12 minutes is kept the temperature, is then cooled to 60 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
110 DEG C are heated to, filtering withered and yellow to medicinal material is fried, then the removing dregs of a decoction are cooled to 60 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating heating
To 110 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Comparative example 4
Burn and scald and the Chinese medicine finish of diaper dermatitis are treated, the component of following parts by weight is included:10 parts of Asian puccoon, radix scutellariae 10
355 parts of part, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale, 6.6 parts of garden burnet, 10 parts of folium isatidis, 5 parts of radix paeoniae rubra, 5 parts of the root bark of tree peony and sesame oil.
The preparation method of above-mentioned treatment burn and scald and the Chinese medicine finish of diaper dermatitis, includes the following steps:
(1) sesame oil is taken, is heated to 118 DEG C, 12 minutes is kept the temperature, is then cooled to 60 DEG C;
(2) Chinese medicine composition in addition to Asian puccoon and folium isatidis is added in the sesame oil obtained by step (1), is slowly heated
110 DEG C are warming up to, filtering withered and yellow to medicinal material is fried, then the removing dregs of a decoction are cooled to 60 DEG C;
(3) water of 0.1 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) by after wetting Asian puccoon and folium isatidis be added in the sesame oil obtained by step (2), slow heating be warming up to 110
DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and is made.
Specific ingredient refers to table 1 in each embodiment;
Table 1:Each embodiment component list
Asian puccoon | Radix scutellariae | Cortex Phellodendri | Rheum officinale | Garden burnet | Folium isatidis | Radix paeoniae rubra | The root bark of tree peony | Radix Angelicae Sinensis | Safflower | |
1 finish of embodiment | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
2 finish of embodiment | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 | 12 |
3 finish of embodiment | 10 | 10 | 10 | 10 | 6.6 | 10 | 5 | 5 | 5 | 2.4 |
4 finish of embodiment | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 | 67 |
5 paste of embodiment | 10 | 10 | 10 | 10 | 6.6 | 10 | 5 | 5 | 5 | 2.4 |
6 gelling agent of embodiment | 10 | 10 | 10 | 10 | 6.6 | 10 | 5 | 5 | 5 | 2.4 |
1 finish of comparative example | 10 | 10 | 10 | / | 6.6 | 10 | 5 | 5 | 5 | 2.4 |
2 finish of comparative example | 10 | 10 | / | 10 | 6.6 | / | 5 | 5 | 5 | 2.4 |
3 finish of comparative example | 10 | 10 | 10 | 10 | 6.6 | 10 | / | / | 5 | 2.4 |
4 finish of comparative example | 10 | 10 | 10 | 10 | 6.6 | 10 | 5 | 5 | / | / |
Experimental example
In order to verify the preparation of embodiment 1-4 and comparative example 1-4 in wound healing, anti-inflammatory and ease pain work
With being tested as follows:
1, material
1.1 drug:The Chinese medicine preparation of embodiment 1-4 and comparative example 1-4, ointment for treating burn and scald (Tonghua Maoxiang Pharmaceutical Co., Ltd.
Production) and baby's Groomwell root oil (the Jiangxi bio tech ltd Zheng Xintang).
1.2 animal:SD rats, Kunming mouse, medicine inspecting institute of Yunnan Province provide, half male and half female, routine feeding.
1.3 reagents and strain:Dimethylbenzene, yellow Jackets, acetone-metabisulfite solution and glacial acetic acid.
2, method:
2.1 wound healings are tested
40 SD rats are taken, slough rat back of the body neck hair, about 3cm × 3cm, fasting 1d, free water before experiment for 24 hours.
By 30mgg-1After being anaesthetized to rat ip3% yellow Jackets, scald processing is carried out to rat back, II degree of scald mould is made
Type, every rat back center line both sides respectively make a diameter 3cm2Deep II degree of scald wound.By rat according to gender, weight with
Machine is divided into:Model group, preparation group and ointment for treating burn and scald group are comparable, wherein preparation group without significant difference between every group of rat
It is divided into as tetra- groups of tetra- groups of embodiment 1-4 and comparative example 1-4, totally eight groups;Every group of 4 rats, 8 surface of a wound raise rat single cage.
Same day administration after modeling, daily administration 2 times, 2,5,8,15,17d measure surface of a wound lengthwise and cross with digimatic calipers after modeling
Long diameter calculates surface of a wound area, and Wound healing rate is calculated according to the following formula, and the results are shown in Table 2.
Surface of a wound area × 100% before Wound healing rate=(surface of a wound area after surface of a wound area-administration before administration)/administration
Table 2:Wound healing experimental result
It is learnt by table 2, the preparation of ointment for treating burn and scald, embodiment 1-4 and comparative example 1-4 all has wound healing certain rush
Into effect, the preparation of embodiment 1-4 is more apparent than commercially available ointment for treating burn and scald to the facilitation of wound healing, the preparation of embodiment 1-4
More apparent than comparative example 1-4 to the facilitation of wound healing, especially embodiment 3 is most bright to the facilitation of wound healing
It is aobvious.
2.2 anti-inflammatory effect
2.2.1, paraxylene causes the influence of mice ear
55 mouse are taken, mouse is randomly divided into according to gender, weight:Model group, preparation group, ointment for treating burn and scald group and baby are purple
Careless oil group is comparable, wherein preparation group is divided into as tetra- groups of embodiment 1-4 and comparison without significant difference between every group of mouse
Tetra- groups of 1-4 of example, every group 5, is then applied to mouse right ear, every group of mouse is to medicament by clinic is quasi- by drug with dosage by totally eight groups
Identical, administration 3 times is measured, per minor tick 30min, the two sides before and after animal subject auris dextra 30min is coated with identical dose after the last administration
The proinflammatory agent dimethylbenzene of amount, left ear is without any processing, and mouse cervical dislocation is put to death after 1h, cuts ears card punch respectively same
Round auricle is laid at one position, and swelling and swelling inhibiting rate is calculated according to the following formula in precise weighing.Mice auricle swelling degree is with every
The average value of the difference of mouse or so ear quality indicates that experimental result is shown in Table 3.
Swelling inhibiting rate=(model group swelling-administration group swelling)/model group swelling × 100%
Table 3:Paraxylene causes the influence of mice ear
Learnt by table 3, ointment for treating burn and scald, Groomwell root oil, embodiment 1-4 and comparative example 1-4 preparation have to mice ear
There is certain inhibiting effect, the preparation of embodiment 1-4 is to the inhibiting effect of mice ear than commercially available ointment for treating burn and scald and Asian puccoon
Oily apparent, the preparation of embodiment 1-4 is more apparent than comparative example 1-4 to the inhibiting effect of mice ear, and especially embodiment 3 is right
The inhibiting effect of mice ear is most apparent.
2.2.2, paraxylene causes the influence of mouse skin capillary permeability
55 mouse are taken, mouse is randomly divided into according to gender, weight:Model group, preparation group, ointment for treating burn and scald group and baby are purple
Careless oil group is comparable, wherein preparation group is divided into as tetra- groups of embodiment 1-4 and comparison without significant difference between every group of mouse
Tetra- groups of 1-4 of example, totally eight groups, every group 5, administration loses hair or feathers to mouse in first 24 hours, and second day after depilation, each group is respectively at the back of the body
Lose hair or feathers regional administration in portion, is administered 4 times altogether, in mouse tail vein saline injection after every minor tick 1h, last dose 1h, immediately
After mouse back unhairing position center melted paraxylene, 20min clocks, mouse cervical dislocation is put to death, and skin of back, every piece of skin are peeled
It is shredded with operating scissors, in input tool plug teat glass, pours into acetone-metabisulfite solution, placed in dark place, gently shake this daily
Test tube 2~3 times, 2000r/min centrifuges 10min after 3d, takes supernatant to measure absorbance (A) at 610nm, based on following equation
Inhibiting rate is calculated, not impregnate acetone-metabisulfite solution school zero of skin, experimental result is shown in Table 4.
Inhibiting rate=(model group be averaged A- administration groups be averaged A)/model group is averaged A × 100%
Table 4:Paraxylene causes the influence of mouse skin capillary permeability
Dosage/gml-1 | A | Inhibiting rate/% | |
Model group | ---- | 0.8±0.1 | - |
Embodiment 1 | 0.50 | 0.5±0.2 | 28.6 |
Embodiment 2 | 0.50 | 0.5±0.2 | 28.6 |
Embodiment 3 | 0.50 | 0.3±0.2 | 57.1 |
Embodiment 4 | 0.50 | 0.4±0.2 | 42.9 |
Comparative example 1 | 0.50 | 0.6±0.2 | 14.3 |
Comparative example 2 | 0.50 | 0.6±0.2 | 14.3 |
Comparative example 3 | 0.50 | 0.6±0.1 | 14.3 |
Comparative example 4 | 0.50 | 0.6±0.2 | 14.3 |
Commercially available ointment for treating scald | 0.50 | 0.5±0.2 | 28.6 |
Baby's Groomwell root oil | 0.50 | 0.6±0.2 | 14.3 |
It is learnt by table 4, the preparation of embodiment 1-4 and comparative example 1-4 all have the capillary of skin permeability of mouse
Certain inhibiting effect, the preparation of embodiment 1-4 is to the inhibiting effect of the capillary of skin permeability of mouse than commercially available burning
Ointment for treating scald and Groomwell root oil are apparent, and the preparation of embodiment 1-4 compares the inhibiting effect of the capillary of skin permeability of mouse
Ratio 1-4 is apparent, and the especially preparation of embodiment 3 is most apparent to the inhibiting effect of the capillary of skin permeability of mouse.
2.3 pairs of glacial acetic acid cause the influence (analgesic activity) of mouse writhing reaction
Kunming mouse 55 is taken, mouse is randomly divided into according to gender, weight:Model group, preparation group, ointment for treating burn and scald group and
Baby's Groomwell root oil group is comparable without significant difference between every group of mouse, and wherein preparation group is divided into as tetra- groups of embodiment 1-4
It with tetra- groups of comparative example 1-4, totally eight groups, every group 5, loses hair or feathers for 24 hours before experiment, every group of animal administration in the 2nd day, is administered 4 altogether after depilation
It is secondary, per mouse ip0.7% glacial acetic acid after every minor tick 30min, last dose 20min, writhing in mouse 15min is observed and recorded immediately
Number (writhing response:Abdomen indent, trunk and back leg are upheld, buttocks is raised, body bilateral twists), suppression is calculated according to the following formula
Rate processed, experimental result are shown in Table 5.
Inhibitory rate=(model group writhing number-administration group writhing number)/model group writhing number × 100%
Table 5:The influence of mouse writhing reaction is caused to glacial acetic acid
Dosage/gml-1 | Writhing number/time | Inhibiting rate/% | |
Model group | - | 26.0±10.2 | - |
Embodiment 1 | 0.50 | 22.4±5.7 | 14.8 |
Embodiment 2 | 0.50 | 22.6±6.3 | 14.1 |
Embodiment 3 | 0.50 | 18.4±5.2 | 30.0 |
Embodiment 4 | 0.50 | 21.4±5.1 | 18.6 |
Comparative example 1 | 0.50 | 23.5±3.4 | 10.6 |
Comparative example 2 | 0.50 | 24.6±5.1 | 6.5 |
Comparative example 3 | 0.50 | 24.6±5.2 | 6.5 |
Comparative example 4 | 0.50 | 25.1±3.4 | 4.6 |
Ointment for treating burn and scald | 0.50 | 23.6±5.1 | 10.3 |
Groomwell root oil | 0.50 | 25.9±4.8 | 1.5 |
Learnt by table 5, ointment for treating burn and scald, Groomwell root oil, embodiment 1-4 and comparative example 1-4 preparation cause mouse to turn round in glacial acetic acid
Precursor reactant all has certain inhibiting effect, and the preparation of embodiment 1-4 causes the inhibiting effect of mouse writhing reaction equal in glacial acetic acid
More apparent than commercially available ointment for treating burn and scald and Groomwell root oil, the preparation of embodiment 1-4 causes the inhibiting effect of mouse writhing reaction equal in glacial acetic acid
More apparent than comparative example 1-4, especially embodiment 3 causes the inhibiting effect of mouse writhing reaction most apparent in glacial acetic acid.
Test example
In order to illustrate Chinese medicine composition of the invention to the clinical therapeutic efficacy of burn and scald, following observation of curative effect has been carried out.
One, the effect of burn and scald, is observed
1, patient data collects
Outpatient service in March, 2013 is chosen to the 200 slight burned patients accepted for medical treatment during in December, 2017, is randomly divided into examination
Group and control group are tested, it is 3 groups, respectively test group 1- test groups 3 to be divided into test group, and control group is 1 group, every group 50, often
Women 25 in group, male 25, the age between 3-70 Sui, average age be (36 ± 3.5) year, without aobvious between every group of patient
Difference is write, is comparable, uses the patient of test group 1-3 the system according to embodiment 3, embodiment 5 and embodiment 6 respectively
Agent uses commercially available ointment for treating burn and scald (Tonghua Maoxiang Pharmaceutical Co., Ltd.'s production) to the patient of control group.
2, curative effect determinate standard
Recovery from illness:After treatment, simultaneously medicine scab falls off for surface of a wound incrustation healing, and without any infection and pain condition;
Effectively:After treatment, the surface of a wound heals substantially, and residual fraction is not cured or wound exudate is reduced, and without infection;
In vain:Surface of a wound area is after the treatment without reduction or infection.
3, therapy
Finish:If there is bubble, bubble is first punctured, squeezes out secretion, the surface of a wound is cleared up, by finish Chinese medicine composition obtained
Preparation is applied to wounds, daily to smear 2 times;
Paste:If there is bubble, bubble is first punctured, squeezes out secretion, the surface of a wound is cleared up, by paste Chinese medicine composition obtained
Preparation is applied to wounds, daily to smear 2 times;
Gelling agent:If there is bubble, bubble is first punctured, squeezes out secretion, the surface of a wound is cleared up, by gelling agent Chinese medicine group obtained
It closes object preparation and is applied to wounds, it is daily to smear 2 times;
4, result
Every group of patient is observed using the synthesis Cure after relative medicine and is recorded, concrete outcome is shown in Table 6.
Table 6:Burn and scald treatment table
It is learnt by experiment, in terms of the treatment of slight burn and scald, according to the side of embodiment 3, embodiment 5 and embodiment 6
The therapeutic effect for the preparation that method and formula ratio are produced is suitable, and is better than the therapeutic effect of commercially available ointment for treating scald.
Typical case
Case one, Zhang, man, 36 years old, leg was scalded by boiler.Doctor first punctures bubble, squeezes out secretion, clears up the surface of a wound
After secretion, the Chinese medicine preparation of embodiment 3 is dipped with cotton swab, light coating is each daily morning and evening to apply once in the surface of a wound, and second day red and swollen bright
Aobvious to subside, after 7 days, the surface of a wound is dry, forms a scab, and after 15 days, incrustation falls off, and is almost recovered.
Two, the effect of pediatric diaper dermatitis, is observed
1, patient data collects
Outpatient service in June, 2014 is chosen to the 200 diaper rash patients accepted for medical treatment during in December, 2017, is randomly divided into test group
And control group, it is 3 groups, respectively test group 1- test groups 3 to be divided into test group, and control group is in 1 group, every group 50, every group
Women 25, male 25, the age between 0-3 Sui, average age be (0.6 ± 0.3) year, without significance difference between every group of patient
It is different, it is comparable, the preparation according to embodiment 3, embodiment 5 and embodiment 6 is used to the patient of test group 1-3 respectively, it is right
The patient of control group uses commercially available baby's Groomwell root oil (the Jiangxi bio tech ltd Zheng Xintang).
2, curative effect determinate standard
Recovery from illness:After treatment, the lesions such as flush, fash, skin lesion, diabrosis and erosion situations all disappears, illing skin with just
Normal skin indifference;
Effectively:After treatment, illing skin fash phenomenon is compared to 2/3 or more reduction, no diabrosis and erosion before treatment;
In vain:Affected part is unchanged compared to before treatment or aggravates.
3, therapy
Finish:Finish Chinese medicinal composition preparation obtained is applied to affected part, it is daily to smear 2 times;
Paste:Paste Chinese medicinal composition preparation obtained is applied to affected part, it is daily to smear 2 times;
Gelling agent:Gelling agent Chinese medicinal composition preparation obtained is applied to affected part, it is daily to smear 2 times;
4, result
Every group of patient is observed using the synthesis Cure after relative medicine and is recorded, concrete outcome is shown in Table 7.
Table 7:Diaper rash treatment table
It is learnt by experiment, in terms of the treatment of infant diaper rash, according to the side of embodiment 3, embodiment 5 and embodiment 6
The therapeutic effect for the preparation that method and formula ratio are produced is suitable, and is better than the therapeutic effect of commercially available baby's Groomwell root oil.
Typical case
Case one, poplar, man, 9 months, buttocks was red and swollen, suffers from diaper rash.It smears after having a bath daily morning and evening or after cleaning and implements
The Chinese medicine preparation of example 3 is gently massaged into and fully absorbs, second day, and red and swollen substantially reduced, fash reduces, and after 4 days, affected part is red and swollen
It disappears, fash drying incrustation, after 7 days, skin restores normal condition.Case two, Yan, female, 12 months, buttocks was red and swollen, suffered from urine
Cloth rash.The Chinese medicine preparation that embodiment 5 is smeared after having a bath daily morning and evening or after cleaning, is gently massaged into and fully absorbs, second day, red
Swollen substantially reduced, fash reduces, and after 4 days, affected part redness disappears, and fash drying incrustation, after 7 days, skin restores normal condition.
Claims (10)
1. treating burn and scald and the Chinese medicine composition of diaper dermatitis, which is characterized in that include the component of following parts by weight:Asian puccoon 4-
67 parts, 4-67 parts of radix scutellariae, 4-67 parts of Cortex Phellodendri, 4-67 parts of rheum officinale, 4-67 parts of garden burnet, 4-67 parts of folium isatidis, 4-67 parts of radix paeoniae rubra, the root bark of tree peony
4-67 parts of 4-67 parts, 4-67 parts of Radix Angelicae Sinensis and safflower.
2. treatment burn and scald and the Chinese medicine composition of diaper dermatitis as described in claim 1, which is characterized in that including following heavy
Measure the component of part:11-12 parts of Asian puccoon, 11-12 parts of radix scutellariae, 11-12 parts of Cortex Phellodendri, 11-12 parts of rheum officinale, 5-8 parts of garden burnet, folium isatidis
2-4 parts of 11-12 parts, 4-6 parts of radix paeoniae rubra, 4-6 parts of the root bark of tree peony, 4-6 parts of Radix Angelicae Sinensis and safflower.
3. as claimed in claim 1 or 2 treatment burn and scald and diaper dermatitis Chinese medicine composition, which is characterized in that including with
The component of lower parts by weight:10 parts of Asian puccoon, 10 parts of radix scutellariae, 10 parts of Cortex Phellodendri, 10 parts of rheum officinale, 6.6 parts of garden burnet, 10 parts of folium isatidis, radix paeoniae rubra 5
Part, 5 parts of the root bark of tree peony, 5 parts of Radix Angelicae Sinensis and 2.4 parts of safflower.
4. treating burn and scald and the Chinese medicine preparation of diaper dermatitis, which is characterized in that including in claim 1-3 any one of them
Drug composition and auxiliary material, and the Chinese medicine preparation is finish, paste or gelling agent.
5. treating the Chinese medicine preparation of burn and scald and diaper dermatitis, which is characterized in that when the preparation is finish, auxiliary material used and its
Weight ratio with Chinese medicine composition is:Sesame oil:Chinese medicine composition is 4-5:1.
6. treating the Chinese medicine preparation of burn and scald and diaper dermatitis, which is characterized in that when the preparation is paste, auxiliary material used and its
Weight ratio with Chinese medicine composition is:Vaseline:Chinese medicine composition is 3-4:1.
7. treating the Chinese medicine preparation of burn and scald and diaper dermatitis, which is characterized in that when the preparation is gelling agent, auxiliary material used and
The weight ratio of itself and Chinese medicine composition is:Carbomer:Citric acid:Glycerine:Tween-80:Chinese medicine composition is 0.1-0.2:
0.05-0.2:0.1-0.3:0.1-0.3:1.
8. the preparation method for the treatment of burn and scald according to claim 5 and the Chinese medicine preparation of diaper dermatitis, which is characterized in that
Include the following steps:
(1) sesame oil is taken, is heated to 110-125 DEG C, 8-13 minutes is kept the temperature, is then cooled to 50-70 DEG C;
(2) the Chinese medicine composition component in addition to Asian puccoon, safflower, folium isatidis is added in the sesame oil obtained by step (1), slowly
It is heated to 100-120 DEG C, fries, filtering withered and yellow to medicinal material, then the removing dregs of a decoction are cooled to 50-70 DEG C;
(3) water of 0.1-0.3 times of medicinal material weight is added into Asian puccoon, safflower and folium isatidis, is soaked;
(4) Asian puccoon, safflower and the folium isatidis after wetting are added in the sesame oil obtained by step (2), slow heating is warming up to
100-120 DEG C, it is in aubergine to fry to fluid, and filtering removes the dregs of a decoction, dries in the air cool, dispenses, and finish is made.
9. the preparation method for the treatment of burn and scald according to claim 6 and the Chinese medicine preparation of diaper dermatitis, which is characterized in that
Include the following steps:
(1) absolute ethyl alcohol of 3-4 times of medicinal material weight is added into Asian puccoon, impregnates 5-8 hours, it is small that 3-4 is extracted at 70-80 DEG C
When, filtering obtains the first extracting solution and filter residue, and the water of 3-4 times of filter residue weight is added into filter residue, and it is small that 2-3 is extracted at 70-80 DEG C
When, filtering obtains the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and the Asian puccoon that relative density is 1.05-1.25 is made and carries
Take object;
(2) radix scutellariae, Cortex Phellodendri, rheum officinale, garden burnet, radix paeoniae rubra, the root bark of tree peony and Radix Angelicae Sinensis are mixed, 3-4 times of medicinal material weight is added into mixture
Water, impregnate 5-8 hour, extracted 3-4 hours at 90-100 DEG C, filtering, the first extracting solution and filter residue are obtained, then by folium isatidis
It is added in filter residue with safflower, the water of 3-4 times of filter residue mixture weight is added into filter residue mixture, 2- is extracted at 90-100 DEG C
3 hours, filtering obtained the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and it is the clear of 1.05-1.25 that relative density, which is made,
Cream;
(3) vaseline is added to the container, big fire is heated 3-6 minutes;
(4) vaseline that the Radix Arnebiae extract obtained by step (1) and the Chinese medicine clear cream obtained by step (2) are added to step (3) is molten
In liquid, slow boiling boils 15-30 minutes, is stirred continuously simultaneously, filters out residue, dries in the air cool, dispenses, and paste is made.
10. the preparation method for the treatment of burn and scald according to claim 7 and the Chinese medicine preparation of diaper dermatitis, feature exist
In including the following steps:
(1) absolute ethyl alcohol of 3-4 times of medicinal material weight is added into Asian puccoon, impregnates 5-8 hours, it is small that 3-4 is extracted at 70-80 DEG C
When, filtering obtains the first extracting solution and filter residue, and the water of 3-4 times of filter residue weight is added into filter residue, and it is small that 2-3 is extracted at 70-80 DEG C
When, filtering obtains the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and the Asian puccoon that relative density is 1.05-1.25 is made and carries
Take object;
(2) radix scutellariae, Cortex Phellodendri, rheum officinale, garden burnet, radix paeoniae rubra, the root bark of tree peony and Radix Angelicae Sinensis are mixed, 3-4 times of medicinal material weight is added into mixture
Water, impregnate 5-8 hour, extracted 3-4 hours at 90-100 DEG C, filtering obtains the first extracting solution and filter residue, by folium isatidis and red
Flower is added in filter residue, and the water of 3-4 times of filter residue mixture weight is added into filter residue mixture, and it is small that 2-3 is extracted at 90-100 DEG C
When, filtering obtains the second extracting solution, merges extracting solution twice, is concentrated under reduced pressure, and the clear cream that relative density is 1.05-1.25 is made;
(3) purified water is added into carbomer, fully after swelling, glycerine, citric acid and Tween-80 is added, stirs evenly,
Obtain gel forming agent;
(4) Radix Arnebiae extract obtained by step (1) and the Chinese medicine clear cream obtained by step (2) are added to the gel obtained by step (3)
It in binder, stirs evenly, dispenses, gelling agent is made.
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CN113975448A (en) * | 2021-11-26 | 2022-01-28 | 李毅 | Collagen composite dressing and preparation method thereof |
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CN1369293A (en) * | 2002-01-11 | 2002-09-18 | 翟学礼 | Chinese-medicinal ointment for treating burn and scald and its preparing process |
CN103055052A (en) * | 2013-01-15 | 2013-04-24 | 张成海 | Cream for treating burn and scald and preparation method of cream |
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