CN108703996A - It is a kind of to have effects that enhance the pure plant group liquid separation of memory - Google Patents
It is a kind of to have effects that enhance the pure plant group liquid separation of memory Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract
Have effects that enhance the pure plant group liquid separation of memory the invention discloses a kind of, is related to natural drug preparation field.A kind of pure plant group liquid separation with enhancing memory of the present invention, includes the raw material of following parts by weight：60-75 parts of Rosemary Oil, 2-4 parts of linalool, 15-25 parts of menthol；Using pure plant natural extract Rosemary Oil, linalool and menthol, be mixed in a certain ratio, obtained pure plant group liquid separation have effects that with fixed attention, flat gas and enhancing memory；Harm does not generate body as raw material using pure plant natural extract simultaneously, has no toxic side effect and suitable for vast ordinary consumer；Preparation method is not simply, conveniently, high to equipment requirement, is easy to implement industrialized production.
Description
Technical field
The present invention relates to natural drug preparation field more particularly to a kind of pure plant components with enhancing memory
Liquid.
Background technology
Memory is memorize, holding, the ability for recognizing and reappearing content and experience that objective things are reflected again, it be into
Row thinking, the imagination etc. are advanced movable basic.With the arrival in social informatization big epoch, it would be desirable to moment holding brain,
The mental labour such as work, study are frequent, are in high pressure conditions for a long time, the ability to bear for brain of excessively overdrawing, and then cause to remember
Recall power decline.In usually living, unhealthy emotion, sleep quality, body or mental disease, age and bad habit etc. are also easy
Lead to failure of memory.With advancing age, especially into person in middle and old age's stage, nerve cell atrophy denaturation is eventually led to
Failure of memory；The reduction of brain midbrain cell number and nerve synapse quantity simultaneously, the speed and quality for causing information to be transmitted
Decline, also results in failure of memory.
Currently, there are many kinds of the domestic and international drugs for preventing failure of memory, still, these chemicals have human body
Certain side effect has potential hazard；And it is all used for pathologic failure of memory substantially, it is not suitable for common decrease of memory
Crowd.
Invention content
In view of the above problems, the present invention provides a kind of pure plant group liquid separation with enhancing memory, this
Kind pure plant group liquid separation is harmless, smells mode by suction of volatilizing to enhance memory.
Aromatotherapy is widely used at present, and main function is attributed to scent molecule and is combined with receptor-specific, via intranasal application
Combined with olfactory epithelium acceptor property, generate electric signal and be transmitted to hippocampus or limbic system through olfactory pathway, adjust autonomic nerve and
Internal system causes vital movement basic instincts or Premium Features.
Rosemary Oil mainly contains amphene, 1,8- cineole, camphor, phellandrene, 4- carenes, laurene and borneol etc.,
Show that sucking Rosemary Oil, there is raising to recognize by zoopery and clinical trial, the bioactivity such as anti-aging, due to
Its high osmosis and volatility, can be by nasal inhalation, and availability is high, quickly and has no toxic side effect, and can improve cognition dysfunction.
Linalool, menthol are natural plant extracts, without any toxicity and side effects, have special fragrance.Menthol has clear
It is cool, comfort；Linalool, with dense leukorrhagia with greenish discharge sweet tea the wooden green gas cease, soft aroma and, can relieve fatigue.
It is of the present invention it is a kind of have effects that enhance memory pure plant group liquid separation be by volatile rosemary
Essential oil, linalool and menthol are mixed to prepare pure plant group liquid separation, are also inhaled by aromatotherapy and smell method to act on body, make machine
Body quickly absorbs；Rosemary Oil, linalool and menthol play the advantage of itself so that pure plant group liquid separation has a kind of spy
Different fragrance, to body generate with fixed attention, flat gas, refresh oneself, enhance memory effect.
The technical solution adopted by the present invention is as follows：
A kind of to have effects that enhance the pure plant group liquid separation of memory, the pure plant group liquid separation includes following parts by weight
Raw material：15~25 parts of 60~70 parts of Rosemary Oil, 2~4 parts of linalool and menthol.
Further, the pure plant group liquid separation includes the raw material of following parts by weight：65~70 parts of Rosemary Oil, agalloch eaglewood
20~25 parts of 2~3 parts of alcohol and menthol.
Further, the pure plant group liquid separation includes the raw material of following parts by weight：65 parts of Rosemary Oil, linalool 3
20 parts of part and menthol.
Further, the raw material all extracts at normal temperatures.
Specifically, a kind of pure plant group liquid separation with enhancing memory, is carried using room temperature from plant
Take active ingredient, avoid the loss and structural damage of active ingredient in high temperature extraction process, be efficiently extracted effectively at
Point.
Further, the Rosemary Oil is extracted from rosemary plant；The linalool is planted from Herba Lysimachiae foenumgraeci
It is extracted in object；The menthol is extracted from lavender and asia peppermint plant.
Further, the mass ratio of the lavender and asia peppermint is 3~7：0.5~3.5.
Further, the preparation method of a kind of pure plant group liquid separation enhance with memory, including it is as follows
Step：
S1. the leaf of plant is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, closing, and pressurization 10~
Liquid is collected in 10~20min of 50MPa, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain the raw material of pure plant group liquid separation.
S4. gained raw material is mixed by formula ratio, is sufficiently stirred to get pure plant group liquid separation.
Further, the pure plant group liquid separation is to smell method by suction to enhance memory.
Further, the pure plant group liquid separation is carried in pharmaceutically acceptable carrier, be prepared into pill, herbal paste,
Powder, tablet and particle slow release object.
The beneficial effects of the invention are as follows：
(1) a kind of pure plant group liquid separation with enhancing memory of the present invention, by the way that pure plant is natural
Extraction of substance Rosemary Oil, linalool and menthol are mixed in a certain ratio so that there is special aroma, suction to smell for group liquid separation
Afterwards, can with fixed attention, flat gas, enhancing memory；Danger body is not generated as raw material using pure plant natural extract matter simultaneously
Evil, has no toxic side effect and is suitable for consumers in general.
(2) a kind of pure plant group liquid separation with enhancing memory of the present invention, using room temperature from plant
Effective component extracting reduces energy consumption, avoids the loss and structural damage of active ingredient in high temperature extraction process, efficiently
It is extracted active ingredient, preparation method is not simply, conveniently, high to equipment requirement, is easy to implement industrialized production.
Specific implementation mode
All features disclosed in this specification or disclosed all methods or in the process the step of, in addition to mutually exclusive
Feature and/or step other than, can combine in any way.
Embodiment 1
65 parts by weight of Rosemary Oil, 20 parts by weight of 3 parts by weight of linalool and menthol are taken to be sufficiently stirred, be sufficiently mixed,
Obtain the pure plant group liquid separation for having effects that enhance memory.
Embodiment 2
60 parts by weight of Rosemary Oil, 25 parts by weight of 2 parts by weight of linalool and menthol are taken to be sufficiently stirred, be sufficiently mixed,
Obtain the pure plant group liquid separation for having effects that enhance memory.
Embodiment 3
70 parts by weight of Rosemary Oil, 15 parts by weight of 4 parts by weight of linalool and menthol are taken to be sufficiently stirred, be sufficiently mixed,
Obtain the pure plant group liquid separation for having effects that enhance memory.
Embodiment 4
It is a kind of to have effects that prepared by the pure plant group liquid separation raw material for enhancing memory：
Rosemary Oil：
S1. a certain amount of rosemary leaf is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 10MPa 20min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain Rosemary Oil.
Linalool：
S1. a certain amount of Herba Lysimachiae foenumgraeci leaf is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 30MPa 15min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain linalool.
Menthol：
S1. a certain amount of lavender and asia peppermint leaf are taken, the mass ratio of lavender and asia peppermint leaf is 7：
3.5, cleaning is dried in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 50MPa 10min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain menthol.
65 parts by weight of Rosemary Oil, 20 parts by weight of 3 parts by weight of linalool and menthol are taken to be sufficiently stirred, fully respectively
Mixing obtains the pure plant group liquid separation for having effects that enhance memory.
Embodiment 5
It is a kind of to have effects that prepared by the pure plant group liquid separation raw material for enhancing memory：
Rosemary Oil：
S1. a certain amount of rosemary leaf is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 50MPa 10min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain Rosemary Oil.
Linalool：
S1. a certain amount of Herba Lysimachiae foenumgraeci leaf is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 10MPa 20min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain linalool.
Menthol：
S1. a certain amount of lavender and asia peppermint leaf are taken, the mass ratio of lavender and asia peppermint leaf is 3：
0.5, cleaning is dried in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 30MPa 15min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain menthol.
60 parts by weight of Rosemary Oil, 25 parts by weight of 2 parts by weight of linalool and menthol are taken to be sufficiently stirred, fully respectively
Mixing obtains the pure plant group liquid separation for having effects that enhance memory.
Embodiment 6
It is a kind of to have effects that prepared by the pure plant group liquid separation raw material for enhancing memory：
Rosemary Oil：
S1. a certain amount of rosemary leaf is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 30MPa 15min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain Rosemary Oil.
Linalool：
S1. a certain amount of Herba Lysimachiae foenumgraeci leaf is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 50MPa 10min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain linalool.
Menthol：
S1. a certain amount of lavender and asia peppermint leaf are taken, the mass ratio of lavender and asia peppermint leaf is 5：2,
Cleaning, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, is closed, pressurization
Liquid is collected in 10MPa 20min, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, liquid
In impurity through the blocking body of filter screen, squeeze block and obtain squeezed fluid, squeezed fluid is collected into layering bottle, static, layering, will point
Layer liquid separation, vacuum distillation obtain menthol.
70 parts by weight of Rosemary Oil, 15 parts by weight of 4 parts by weight of linalool and menthol are taken to be sufficiently stirred, fully respectively
Mixing obtains the pure plant group liquid separation for having effects that enhance memory.
Embodiment 7
To have effects that the pure plant group liquid separation for enhancing memory is carried on obtained by any embodiment in Examples 1 to 6
In pharmaceutically acceptable carrier, it is prepared into pill.
Embodiment 8
To have effects that the pure plant group liquid separation for enhancing memory is carried on obtained by any embodiment in Examples 1 to 6
In pharmaceutically acceptable carrier, it is prepared into herbal paste.
Embodiment 9
To have effects that the pure plant group liquid separation for enhancing memory is carried on obtained by any embodiment in Examples 1 to 6
In pharmaceutically acceptable carrier, it is prepared into powder.
Embodiment 10
By the pure plant group liquid separation liquid load enhance with memory obtained by any embodiment in Examples 1 to 6
In in pharmaceutically acceptable carrier, piece agent is prepared.
Embodiment 11
To have effects that the pure plant group liquid separation for enhancing memory is carried on obtained by any embodiment in Examples 1 to 6
In pharmaceutically acceptable carrier, it is prepared into particle slow release object.
Embodiment 12
Water maze laboratory and result：
Experimental subjects mouse is placed in water maze, the experimental subjects mouse that 3min interior energies are reached to platform leaves and does follow-up reality
It tests, screening is in principle in order to reduce experimental subjects mouse individual difference.
80 experimental subjects mouse by screening are taken to be divided into 5 groups of carry out water maze laboratories, record reaches the time of platform (i.e.
Incubation period), 5 groups are respectively：
Control group：Experimental subjects mouse is without any processing, gives air suction smells；
Sham-operation group：After the intraperitoneal injection of 5% chloraldurate, 50 μ L physiological saline of bilateral nostril instillation, 1 day 1 time, totally 7 days,
Air suction is given to smell；
Model group：Olfactory epithelium damages, and after the intraperitoneal injection of 5% chloraldurate, bilateral nostril instills 50 μ L 0.15mol/L's
ZnSO4PBS solution 1 day 1 time, totally 7 days, is given air suction and is smelt；
Model+pure plant group liquid separation：Olfactory epithelium damages, and after the intraperitoneal injection of 5% chloraldurate, bilateral nostril instills 50 μ L
The ZnSO of 0.15mol/L4- PBS 1 day 1 time, totally 7 days, gives pure plant group liquid separation suction and smells；
Normal group：Experimental subjects mouse is without any processing, gives pure plant group liquid separation suction smells；
Processing is completed, and is rested 5 days and is carried out water maze laboratory, data are for statistical analysis with SPSS13.0 editions softwares, used
Continuous data is indicated with mean ± standard deviation；As a result as table 1 is shown：
The time required to 1 experimental subjects mouse of table reaches water maze platform
Before suction is smelt, control group, normal group, model group, sham-operation group and model+pure plant group liquid separation incubation period without apparent
Difference (P>0.05)；Model group, model+liquid separation of pure plant group, sham-operation group and control group have smelt pure plant group liquid separation in suction
6,12 days incubation period no significant difference (P>0.05).The liquid separation of pure plant group has been smelt in suction the 6th, 12 day, the incubation period normally organized
It is obviously shortened, the incubation period significant difference (P < 0.05) with control group, illustrates that pure plant group liquid separation is to smell access by suction to reach
To enhancing memory effect.
The c-fos immune response positive products in the areas experimental subjects mouse hippocampus CAL after above-mentioned experiment are measured,
Since it is mainly deposited in nucleus, using positive cell number as basis for estimation.As a result as table 2 is shown：
2 c-fos- positive cell numbers of table
| Test group | Positive cell number |
| Control group | 5.8 |
| Normal group | 8.0 |
| Model group | 6.1 |
| Model+pure plant group liquid separation | 6.3 |
| Sham-operation group | 5.3 |
Known by table 2, normal group is apparent (P < 0.05) with control group difference, inhales the sea for the mouse for having smelt pure plant group liquid separation
Horse c-fos sample immuning positive cell numbers increase, and show that the areas hippocampus CAL take part in pure plant component and inhale the mistake for smelling enhancing memory
Journey.
A kind of pure plant group liquid separation with enhancing memory of the present invention, by naturally extracting pure plant
Substance Rosemary Oil, linalool and menthol are mixed in a certain ratio so that, can after there is special aroma, suction to smell for group liquid separation
With fixed attention, flat gas, enhancing memory；Harm does not generate body as raw material using pure plant natural extract matter simultaneously, it is nontoxic
Side effect and it is suitable for consumers in general；Furthermore preparation method is simply, conveniently, not high to equipment requirement, is easy to implement industrialization
Production.
The invention is not limited in more excellent specific implementation modes above-mentioned.The present invention expands to any to drape over one's shoulders in the present specification
The new feature of dew or any new combination, and disclose any new method or process the step of or any new combination.
Claims (9)
1. it is a kind of have effects that enhance memory pure plant group liquid separation, which is characterized in that the pure plant group liquid separation include with
The raw material of lower parts by weight：15~25 parts of 60~70 parts of Rosemary Oil, 2~4 parts of linalool and menthol.
2. a kind of pure plant group liquid separation with enhancing memory as described in claim 1, which is characterized in that described pure
Plant component liquid includes the raw material of following parts by weight：65~70 parts of Rosemary Oil, 2~3 parts of linalool and menthol 20~25
Part.
3. a kind of pure plant group liquid separation with enhancing memory as described in claim 1, which is characterized in that described pure
Plant component liquid includes the raw material of following parts by weight：20 parts of 65 parts of Rosemary Oil, 3 parts of linalool and menthol.
4. a kind of pure plant group liquid separation with enhancing memory as described in claim 1, which is characterized in that the original
Material all extracts at normal temperatures.
5. a kind of pure plant group liquid separation with enhancing memory as described in claim 1, which is characterized in that the fan
Repeatedly essential oil is extracted from rosemary plant；The linalool is extracted from Herba Lysimachiae foenumgraeci plant；The menthol is
It is extracted from lavender and asia peppermint plant.
6. a kind of pure plant group liquid separation with enhancing memory as claimed in claim 5, which is characterized in that the Europe
The mass ratio of peppermint and asia peppermint is 3~7：0.5~3.5.
7. a kind of pure plant group liquid separation with enhancing memory as described in claim 1, which is characterized in that preparation side
Method includes the following steps：
S1. the leaf of plant is taken, cleans, dries in the shade to water tariff collection 15~18%；
S2. at normal temperatures, extracting container is cleaned, is sterilized, and S1 gains are added in container, closing, and pressurization 10~
Liquid is collected in 10~20min of 50MPa, abrupt release pressure, plant walls rupture, liquid outflow；
S3. by liquid obtained by S2 and medium reverse convection, the active ingredient in medium belt hydrodynamic body enters layering bottle, in liquid
Impurity squeezes block and obtains squeezed fluid through the blocking body of filter screen, and squeezed fluid is collected into layering bottle, static, and layering will be layered liquid
Separation, vacuum distillation, obtains the raw material of pure plant group liquid separation.
S4. gained raw material is mixed by formula ratio, is sufficiently stirred to get pure plant group liquid separation.
8. such as a kind of pure plant group liquid separation with enhancing memory according to any one of claims 1 to 7, feature
It is, the pure plant group liquid separation is to smell method by suction to enhance memory.
9. a kind of pure plant group liquid separation with enhancing memory as described in claim 1, which is characterized in that described pure
Plant component liquid is carried in pharmaceutically acceptable carrier, is prepared into pill, herbal paste, powder, tablet and particle slow release object.
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