CN108699068B - 一种三氟甲基取代的吡喃衍生物制备方法 - Google Patents

一种三氟甲基取代的吡喃衍生物制备方法 Download PDF

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CN108699068B
CN108699068B CN201780011295.4A CN201780011295A CN108699068B CN 108699068 B CN108699068 B CN 108699068B CN 201780011295 A CN201780011295 A CN 201780011295A CN 108699068 B CN108699068 B CN 108699068B
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formula
solvent
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water
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CN108699068A (zh
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张校伟
赵富强
刘兆军
隆元强
刘珍
张晨
王建民
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Sichuan Haisco Pharmaceutical Co Ltd
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Sichuan Haisco Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201780011295.4A 2016-05-25 2017-05-25 一种三氟甲基取代的吡喃衍生物制备方法 Active CN108699068B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201610357293 2016-05-25
CN2016103572938 2016-05-25
CN201611053098 2016-11-25
CN2016110530982 2016-11-25
PCT/CN2017/085925 WO2017202365A1 (fr) 2016-05-25 2017-05-25 Procédé de préparation d'un dérivé de pyranne substitué par un trifluorométhyle

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CN108699068A CN108699068A (zh) 2018-10-23
CN108699068B true CN108699068B (zh) 2021-01-08

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WO (1) WO2017202365A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3750539A4 (fr) 2018-02-06 2021-12-15 Sichuan Haisco Pharmaceutical Co., Ltd. Composition de dérivé d'aminopyrane
CN110894198B (zh) * 2018-09-13 2022-12-02 齐鲁制药有限公司 一种黄嘌呤类化合物及其制备方法和用途
EP3988545A1 (fr) * 2019-06-21 2022-04-27 Gan & Lee Pharmaceuticals Co., Ltd. Procédés de préparation d'un inhibiteur de cdk4/6 et sel et intermédiaire de celui-ci
CN111253348A (zh) * 2020-03-06 2020-06-09 天津全和诚科技有限责任公司 一种2,3,5-三苄氧基-d-核糖酸-1,4-内酯的制备方法
CN113651861A (zh) * 2020-05-12 2021-11-16 鲁南制药集团股份有限公司 一种托吡酯杂质
CN113929612B (zh) * 2020-06-29 2024-05-14 鲁南制药集团股份有限公司 一种依托度酸中间体的制备方法
CN111689919A (zh) * 2020-07-22 2020-09-22 天津市中升挑战生物科技有限公司 一种异噁唑啉类驱虫药的合成方法
CN115124578B (zh) * 2021-03-29 2024-05-10 上海医药工业研究院 一种络塞维中间体、其制备方法和用途

Family Cites Families (6)

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CN101410400B (zh) * 2006-03-28 2012-09-05 默沙东公司 作为用于糖尿病治疗或者预防的二肽基肽酶-ⅳ抑制剂的氨基四氢吡喃
TW200806669A (en) * 2006-03-28 2008-02-01 Merck & Co Inc Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
JO2870B1 (en) * 2008-11-13 2015-03-15 ميرك شارب اند دوهم كورب Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
WO2014018350A1 (fr) * 2012-07-23 2014-01-30 Merck Sharp & Dohme Corp. Traitement du diabète par administration d'inhibiteurs de dipeptidyl peptidase-iv
CN105518008B (zh) * 2014-06-17 2018-03-27 海思科医药集团股份有限公司 氨基吡喃环衍生物及其组合物和应用
WO2017202357A1 (fr) * 2016-05-25 2017-11-30 四川海思科制药有限公司 Procédé de préparation d'un dérivé de pyranne substitué par un trifluorométhyle

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CN108699068A (zh) 2018-10-23

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