CN108686724A - A kind of micro-fluidic time control valve - Google Patents
A kind of micro-fluidic time control valve Download PDFInfo
- Publication number
- CN108686724A CN108686724A CN201710228545.1A CN201710228545A CN108686724A CN 108686724 A CN108686724 A CN 108686724A CN 201710228545 A CN201710228545 A CN 201710228545A CN 108686724 A CN108686724 A CN 108686724A
- Authority
- CN
- China
- Prior art keywords
- runner
- micro
- control valve
- liquid pool
- time control
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 claims abstract description 77
- 238000005452 bending Methods 0.000 claims description 8
- 239000004744 fabric Substances 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 8
- 239000012530 fluid Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 230000001788 irregular Effects 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
Abstract
The present invention relates to a kind of micro-fluidic time control valves comprising at least one runner passes through one or more realization time control valve functions in the size of the runner, shape, structure.It further may also include the liquid pool being connect with the runner, constitute runner-liquid pool combined flow channel, and pass through one or more realization time control valve functions in the size of runner and liquid pool, shape, structure.The present invention can be flowed into the time in another region by the fixing fabric structure solution of control runner by a region, realize the function of time control valve;And solution can be controlled by adjusting the sectional area of runner and enter the flow of specific region, realize to solution desired zone flow control;If runner and liquid pool, which are embedded in micro-structure again, can realize the functions such as solution mixing.The micro-fluidic time control valve of the present invention without labyrinth, without mobile unit, have many advantages, such as that simple, the of low cost and service life of making is long, have broad application prospects in micro-fluidic and related field.
Description
Technical field
The invention belongs to microfluidic arts, and in particular to a kind of micro-fluidic time control valve.
Background technology
Micro-fluidic chip (Microfluidic chip) refers to by micro-processing technology (MEMS), injection molding technology and other
The basic function micro of one biology, chemical laboratory is only had several square centimeters of big chip tops by processing method to one piece,
Network is generally formed by microchannel, runs through whole system with controlled fluid, to realize each of conventional chemical or biology laboratory
Kind function.It is with sample substantially in terms of being analyzed with the function realization of detection micro-fluidic chip specific to various chemistry of micro-organisms
Premised on accurate effective control being obtained with processes such as transport, mixing and reaction of the reagent in micro-fluidic chip.This control
System needs to realize by micro-fluidic time control valve that is efficient, accurate, stable and being combined with micro-fluidic chip.
The time control valve in micro-fluidic chip can be divided into according to crucial time control component at present:Movable member is controlled and is fixed
Component controls two major classes.Micro-fluidic valve based on movable member control utilizes thermotropic, the electroluminescent expansion of mobile unit or material
The different functions of realizing valve break-make of coefficient, such as heat responsive deformation driving valve and air pressure drive valve;It is controlled based on fixed component
Micro-fluidic valve be using microfluid property realize valve on-off function, as phase transformation valve (by adjust microfluid temperature change
Become its solid, liquid state, and then realize the function of solution break-make).
The above valve be required to by means of outside control realize valve on-off function, such as provide deformable material temperature or
Voltage driving, the air pressure driving of micro-valve door rotation or the driving of microfluidic phase change temperature etc..The micro-fluidic valve of mobile unit control
The problems such as also needing to durability degree and the stability that consideration chip uses.It is accurate that these problems so that valve controls fluid on-off
Property, stability are had a greatly reduced quality, and the uncertainty that micro-fluidic chip uses undoubtedly are increased, to influence the analysis of micro-fluidic chip
As a result.Meanwhile by extraneous governing factor the manufacture difficulty of chip and use cost are difficult to decrease.
In conclusion how to provide a kind of high stability, low manufacture difficulty and prepare simple low-cost microfluidic valve
Door, is current those skilled in the art technical problem urgently to be resolved hurrily.
Invention content
For the problems of the above micro-fluidic valve, the purpose of the present invention is to propose to a kind of micro-fluidic time control valve, from
And break traditional time control realized using the mode of valve break-make reach micro-fluidic chip specific region to microfluid merely.
The micro-fluidic time control valve can not only realize accurate, stability contorting to microfluid;It can also realize the liquid to time control valve both sides
Body flow is controlled;Have many advantages, such as that manufacture craft is simple, manufacture difficulty is low and of low cost simultaneously.
In order to achieve the above objectives, technical solution provided by the invention is as follows:
A kind of micro-fluidic time control valve, including at least one runner, by the size of the runner, shape, structure
One or more realization time control valve functions.
Further, the micro-fluidic time control valve further includes the liquid pool being connect with the runner, the liquid pool and described
Runner constitutes runner-liquid pool combined flow channel, and the runner-liquid pool combined flow channel passes through the size of runner and liquid pool, shape, structure
In one or more realization time control valve functions.
Further, in the runner-liquid pool combined flow channel, runner, liquid pool built-up sequence can be runner-liquid pool
Combination;It can be the combination of runner-liquid pool-runner;It can be the combination of liquid pool-runner;It can be liquid pool-runner-liquid pool
Combination.
Further, the shape of the runner can be straight, can also be bending;The runner of bending can be had
The bending of rule can also be random bending;Definite shape can be integrally presented in runner, can also be disorderly and unsystematic.
Further, the runner can in the same plane, can also be in Different Plane.
Further, the length of the runner, width, depth can be with individually designed sizes, can also be interrelated, realize
Control to microfluid " logical ", " disconnected ".
Further, the section of the runner can be rectangle, rectangular, semicircle, trapezoidal and other polygons.
Further, the runner keeps connecting with liquid pool, can in the same plane, can also be in Different Plane.
Further, the runner, micro-structure can be embedded in inside liquid pool can not also be embedded in micro-structure.Embedded micro-structure
When, the functions such as solution mixing may be implemented.
Further, the runner, inside liquid pool embedded by the shape of micro-structure be any one or a few shape
Combination.
Further, the runner, inside liquid pool embedded by the height of micro-structure identical as flow channel depth also can may be used
To be less than the arbitrary height of flow channel depth.
Further, the runner, inside liquid pool embedded by the arrangement mode of micro-structure can be ordered into arrangement and also may be used
To be random alignment.
Further, the runner, inside liquid pool embedded by the top of micro-structure can be round, rectangular or arc.
Further, the runner, inside liquid pool embedded by the density of micro-structure be arbitrary density, can not also be embedded in
Micro-structure.
Further, the runner, whether to be embedded in micro-structure inside liquid pool mutual indepedent, be independent of each other;Or it is real
Some existing additional functions, such as mixed function are interrelated.
Further, the shape of the liquid pool can be rectangular, round, the semicircle, triangle of rule, can also be not
Regular figure.
Further, the section of the liquid pool can be rectangular, round, the semicircle, triangle of rule, can also be not
Regular figure.
It can be seen from the above technical scheme that miniflow time control valve provided by the invention includes at least a continuous flow path
An or combined flow channel by one or several runner-liquid pools.
The present invention is according to specific requirements, and designing the size of runner or runner-liquid pool combined flow channel, (flow channel length, liquid pool are big
It is small etc.), shape (shape of runner, cross sectional shape, liquid pool shape etc.), structure (whether there is or not micro-structure, the position of micro-structure, micro- knot
Density, shape of structure etc.) realize that microfluid flows into specified region at the appointed time --- realize the work(of time control valve
Energy;The flow rate that time control valve both sides fluid can also be controlled by designing the different sectional dimension of runner, reaches accurate inspection
The purpose of survey.The micro-fluidic chip for entering the same area for multichannel microfluid, when multichannel microfluid stream is through provided by the invention
The passive mixing of multichannel microfluid can also be realized when time control valve.
In summary, compared with prior art, beneficial effects of the present invention are as follows:
1) it may be implemented to meet current micro-fluidic chip to miniflow to the specified accurate time control in region to microfluid stream
Body precisely, the demand of stability contorting;
2) control of flow, flow velocity can be carried out to the microfluid of time control valve two side areas, therefore integrates the time control valve
The micro-fluidic chip of door can adjust flow, the flow velocity of time control valve two side areas according to detection chip demand;
3) present invention realizes that multichannel microfluid may be implemented in the function of time control valve, the long runner by the way of long runner
Mixing, increase the integrated level of micro-fluidic chip and the multifunctionality of time control valve.
4) time control valve of the invention is fixed component, has that manufacture craft is simple, manufacture difficulty is low (may be used injection molding
The methods of forming technique make) and it is of low cost the advantages that.
Description of the drawings
Fig. 1 is two kinds of typical time control valve schematic diagrames.
Fig. 2 is runner appearance schematic diagram of different shapes.
Fig. 3 is the schematic diagram of micro-structure of different shapes.
Fig. 4 is different micro-structure schematic cross-sections.
Fig. 5 is the liquid pool schematic top plan view of different shapes.
Fig. 6 is runner or liquid pool schematic cross-section.
Fig. 7 is cross section of fluid channel schematic diagram.
Fig. 8 is fluid channel-liquid pool combination diagram.
Specific implementation mode
Below by specific embodiments and the drawings, the present invention will be further described.
The micro-fluidic time control valve of the present invention includes at least one runner, by the size of the runner, shape, structure
One or more realization time control valve functions.The liquid pool being connect with runner can also be increased on the basis of runner, constitute runner-liquid
Pond combined flow channel, the runner-liquid pool combined flow channel pass through one or more realities in the size of runner and liquid pool, shape, structure
Current control valve function.That is, the present invention includes at least a continuous flow path or a combination being made of runner, liquid pool
Runner.Fig. 1 is two kinds of typical time control valve schematic diagrames.
The shape of the runner can be straight, can also be bending;The runner of bending can be regular curved
Song can also be random bending;Definite shape can be integrally presented in runner, can also be disorderly and unsystematic.Fig. 2 is stream of different shapes
Road appearance schematic diagram.
Micro-structure can be embedded in inside the runner, liquid pool can not also be embedded in micro-structure.When embedded micro-structure, Ke Yishi
The functions such as existing solution mixing.The shape of the micro-structure is the combination of any one or a few shape.Fig. 3 is of different shapes micro-
The schematic diagram of structure.Fig. 4 is the schematic diagram in different micro-structure sections.The height of micro-structure can it is identical as flow channel depth can also
It is less than the arbitrary height of flow channel depth.It can also be random alignment that the arrangement mode of micro-structure, which can be ordered into arrangement,.Micro- knot
The top of structure can be round, rectangular or arc.The density of micro-structure is arbitrary density, can not also be embedded in micro-structure.Runner,
It is mutual indepedent that it whether is embedded in micro-structure inside liquid pool, is independent of each other.
The shape of the liquid pool can be rectangular, the round, triangle of rule, can also be irregular figure, such as Fig. 5 institutes
Show.
The section of the runner and liquid pool can be rectangular, the round, triangle of rule, can also be irregular figure.
As shown in Figure 6.
In the runner-liquid pool combined flow channel, runner, liquid pool built-up sequence can be the combination of runner-liquid pool;It can be with
It is the combination of runner-liquid pool-runner;It can be the combination of liquid pool-runner;Can be the combination of liquid pool-runner-liquid pool, such as Fig. 7
It is shown.
Micro-fluidic time control valve provided by the invention not only can be by controlling the fixing fabric structure solution of runner by an area
Domain flows into the time in another region, realizes the function of time control valve;The sectional area control that again may be by adjusting runner is molten
Liquid enters the flow of specific region, realize to solution desired zone flow control;If runner and liquid pool are embedded in micro-structure
The functions such as solution mixing may be implemented again;And the micro-fluidic time control valve without labyrinth, without mobile unit.Therefore, this is micro-
Flow control time control valve has many advantages, such as that simple, the of low cost and service life of making is long, has in micro-fluidic and related field wide
Wealthy application prospect.
Fig. 8 is the schematic diagram of the micro-fluidic chip of a specific example, and the chip is by sample introduction zone A, time control valve area B and work(
Energy area C compositions, wherein time control valve is made of curved channel-liquid pool-curved channel, and liquid pool is internally embedded the circle of rule distribution
Rod structure.The micro-fluidic chip is by the cover plate group comprising sample introduction zone A, the substrate of time control valve B and functional areas C and same material
At formation closed flow.Chip material is the good polymethyl methacrylate of bio-compatibility (PMMA), and materials at two layers is logical
Cross the mode sealing-in of thermocompression bonding.Chip is surface-treated using the good water wetted material of bio-compatibility.Time control valve region
Runner-liquid pool-flow channel depth be 60 μm, width of flow path be 40 μm, liquid pool be embedded in body diameter be 50 μm, 70 μ of spacing
m.The micro-fluidic chip carries out sterilizing overnight in medical ultraviolet disinfection tank first, and blood then is added into the inlet of sample introduction zone A
Liquid sample.After blood sample enters time control valve area B by sample introduction zone A, after 10min, into chip functions area C, it was demonstrated that
The feasibility of the time control valve of the present invention.
On the basis of the above embodiments, time control valve equally can be the parallel combination of a plurality of " runner-liquid pool ", in this way
Both can with coutroi velocity can also significantly more efficient control flow, while can play the role of enhance mixing effect of fluid.
The above embodiments are merely illustrative of the technical solutions of the present invention rather than is limited, the ordinary skill of this field
Personnel can be modified or replaced equivalently technical scheme of the present invention, without departing from the spirit and scope of the present invention, this
The protection domain of invention should be subject to described in claims.
Claims (10)
1. a kind of micro-fluidic time control valve, which is characterized in that including at least one runner, by the size of the runner, shape,
One or more realization time control valve functions in structure.
2. micro-fluidic time control valve according to claim 1, which is characterized in that further include the liquid being connect with the runner
Pond, the liquid pool and the runner constitute runner-liquid pool combined flow channel, and the runner-liquid pool combined flow channel passes through runner and liquid
One or more realization time control valve functions in the size in pond, shape, structure.
3. micro-fluidic time control valve according to claim 1 or 2, which is characterized in that the shape of the runner is straight
Or bending;The runner in the same plane, or in Different Plane, spatially structure.
4. micro-fluidic time control valve according to claim 1 or 2, which is characterized in that the section of the runner is rectangular, circle
Shape, trapezoidal, triangle or other polygons.
5. micro-fluidic time control valve according to claim 1 or 2, which is characterized in that the runner inside and/or the liquid
Pond is internally embedded micro-structure, or is not embedded in micro-structure.
6. micro-fluidic time control valve according to claim 5, which is characterized in that the shape of the micro-structure is any one
Or the combination of several shapes;The height of the micro-structure is identical as flow channel depth, or less than the arbitrary height of flow channel depth;
The arrangement mode of the micro-structure is ordered into arrangement either random alignment;It is round, rectangular or arc at the top of the micro-structure
Shape.
7. micro-fluidic time control valve according to claim 2, which is characterized in that the runner-liquid pool combined flow channel includes
At least one runner and at least one liquid pool, the type of attachment between runner and liquid pool are one of the following:Runner-liquid pool;Liquid
Pond-runner;Runner-liquid pool-runner;Liquid pool-runner-liquid pool;Runner-liquid pool-runner-liquid pool.
8. micro-fluidic time control valve according to claim 2, which is characterized in that the shape of the liquid pool be it is rectangular, round,
Semicircle, trapezoidal, triangle or other polygons.
9. micro-fluidic time control valve according to claim 2, which is characterized in that the section of the liquid pool be it is rectangular, round,
Semicircle, trapezoidal, triangle or other polygons.
10. a kind of micro-fluidic chip, which is characterized in that when comprising micro-fluidic described in any claim in claim 1-9
Control valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710228545.1A CN108686724A (en) | 2017-04-10 | 2017-04-10 | A kind of micro-fluidic time control valve |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710228545.1A CN108686724A (en) | 2017-04-10 | 2017-04-10 | A kind of micro-fluidic time control valve |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108686724A true CN108686724A (en) | 2018-10-23 |
Family
ID=63843090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710228545.1A Pending CN108686724A (en) | 2017-04-10 | 2017-04-10 | A kind of micro-fluidic time control valve |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108686724A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101258397A (en) * | 2005-07-14 | 2008-09-03 | 毫微创新科技公司 | Microfluidic devices and methods of preparing and using the same |
| KR20130061114A (en) * | 2011-11-30 | 2013-06-10 | 주식회사 맥스바이오텍 | Lab on a chip, methods for manufacturing pre-natal triple markers and detection kit thereof |
| CN103736528A (en) * | 2013-12-19 | 2014-04-23 | 北京化工大学常州先进材料研究院 | Microfluidic chip for mixing reagent and preparing micro-droplets and micro-liquid column |
| KR101421098B1 (en) * | 2013-05-31 | 2014-07-18 | 고려대학교 산학협력단 | Lap-on-a-chip for multi detection and fluid flow control |
| CN103941022A (en) * | 2014-03-07 | 2014-07-23 | 大连理工大学 | Microfluidic three-dimensional flow delay control unit |
| CN105675859A (en) * | 2016-01-20 | 2016-06-15 | 大连理工大学 | Maze type micro-fluid delay flow control unit |
| CN106093382A (en) * | 2016-07-19 | 2016-11-09 | 大连理工大学 | A kind of comb-tooth-type microfluid chronotron |
| WO2017030455A1 (en) * | 2015-08-18 | 2017-02-23 | Curiosity Diagnostics Sp. Z O.O. | Microfluidic chip with pressure and flow control system |
| CN207576438U (en) * | 2017-04-10 | 2018-07-06 | 苏州含光微纳科技有限公司 | A kind of micro-fluidic time control valve |
-
2017
- 2017-04-10 CN CN201710228545.1A patent/CN108686724A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101258397A (en) * | 2005-07-14 | 2008-09-03 | 毫微创新科技公司 | Microfluidic devices and methods of preparing and using the same |
| KR20130061114A (en) * | 2011-11-30 | 2013-06-10 | 주식회사 맥스바이오텍 | Lab on a chip, methods for manufacturing pre-natal triple markers and detection kit thereof |
| KR101421098B1 (en) * | 2013-05-31 | 2014-07-18 | 고려대학교 산학협력단 | Lap-on-a-chip for multi detection and fluid flow control |
| CN103736528A (en) * | 2013-12-19 | 2014-04-23 | 北京化工大学常州先进材料研究院 | Microfluidic chip for mixing reagent and preparing micro-droplets and micro-liquid column |
| CN103941022A (en) * | 2014-03-07 | 2014-07-23 | 大连理工大学 | Microfluidic three-dimensional flow delay control unit |
| WO2017030455A1 (en) * | 2015-08-18 | 2017-02-23 | Curiosity Diagnostics Sp. Z O.O. | Microfluidic chip with pressure and flow control system |
| CN105675859A (en) * | 2016-01-20 | 2016-06-15 | 大连理工大学 | Maze type micro-fluid delay flow control unit |
| CN106093382A (en) * | 2016-07-19 | 2016-11-09 | 大连理工大学 | A kind of comb-tooth-type microfluid chronotron |
| CN207576438U (en) * | 2017-04-10 | 2018-07-06 | 苏州含光微纳科技有限公司 | A kind of micro-fluidic time control valve |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109967150B (en) | Inertial micro-fluidic chip for controlling micro-nano particles | |
| US9784664B2 (en) | Multidimensional hydrodynamic focusing chamber | |
| CN104525286B (en) | The micro-fluidic chip of drop synchronous fusion is realized based on T-shaped passage | |
| Tanyeri et al. | A microfluidic-based hydrodynamic trap: design and implementation | |
| Chang et al. | Three-dimensional hydrodynamic focusing in two-layer polydimethylsiloxane (PDMS) microchannels | |
| Bhagat et al. | Enhancing particle dispersion in a passive planar micromixer using rectangular obstacles | |
| US20130244270A1 (en) | Microfluidic device for cell motility screening and chemotaxis testing | |
| US20170128941A1 (en) | On-demand particle dispensing system | |
| US9073054B2 (en) | Fluid-controlling device for microchip and use thereof | |
| CN104647903A (en) | Printing spray head device based on microfluidic chip | |
| CN104888875A (en) | Lower wall specified position movable micro-fluidic chip based on microchannel | |
| Kim et al. | Hydrodynamic trap-and-release of single particles using dual-function elastomeric valves: design, fabrication, and characterization | |
| CN105498875A (en) | Centrifugal micro-fluidic chip for preparing liquid drops | |
| CN101290314A (en) | Microfluidic control chip for cell immobilization and solution dilution | |
| CN105195053B (en) | A kind of concussion jetting type micro-mixer based on microbubble driving | |
| Manshadi et al. | Induced-charge electrokinetics in microfluidics: A review on recent advancements | |
| CN207576438U (en) | A kind of micro-fluidic time control valve | |
| CN207894807U (en) | A kind of biochemical analyser based on magnetic bead | |
| CN112007704A (en) | Micro-fluidic chip and method for sorting micro-nano particles by inertial turbulence | |
| Arakawa et al. | Three-dimensional sheath flow sorting microsystem using thermosensitive hydrogel | |
| Shirinkami et al. | Red blood cell and white blood cell separation using a lateral-dimension scalable microchip based on hydraulic jump and sedimentation | |
| CN103062480A (en) | Photo-responsive micro valve based on micro-fluidic chip and production method thereof | |
| CN108993337A (en) | A kind of integrating device of drop fluid micro-reactor | |
| CN105214546A (en) | A kind of concussion jetting type micro-mixer based on Pulsating Flow | |
| CN108686724A (en) | A kind of micro-fluidic time control valve |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |