CN108685744A - The new opplication of Chinese medicine natural plants molecule - Google Patents

The new opplication of Chinese medicine natural plants molecule Download PDF

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Publication number
CN108685744A
CN108685744A CN201710224429.2A CN201710224429A CN108685744A CN 108685744 A CN108685744 A CN 108685744A CN 201710224429 A CN201710224429 A CN 201710224429A CN 108685744 A CN108685744 A CN 108685744A
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chinese medicine
natural plants
black
molecule
medicine natural
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CN201710224429.2A
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Inventor
詹华强
董婷霞
陈嘉伦
吴启韵
黄振辉
莉莎·格莉
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Hong Kong University of Science and Technology HKUST
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Hong Kong University of Science and Technology HKUST
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60Sugars; Derivatives thereof
    • A61K8/602Glycosides, e.g. rutin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/04Preparations for care of the skin for chemically tanning the skin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to the new opplications of Chinese medicine natural plants molecule.Some first public Chinese medicine natural plants molecules of the present invention can enhance tyrosinase activity, can promote the generation of melanin, be finally reached the effect of colour of skin blackening, have U.S. black effect.Wherein, black effect of U.S. of quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides is the most notable.Using Chinese medicine natural plants molecule as U.S. black effect ingredient, apply the risk that can substantially lower on cosmetic products (such as cosmetics), drug or food and other external application big health-oriented products of class and cause cutaneum carcinoma because using chemical synthesis class tanning agent and excessive sun to bathe, and U.S. black significant effect, there is huge market potential.

Description

The new opplication of Chinese medicine natural plants molecule
Technical field
The present invention relates to the applied technical fields of Chinese medicine natural plants molecule, more particularly to a kind of Chinese medicine natural plants point Son is preparing the application in having effects that U.S. black product.
Background technology
It is U.S. it is black be exactly to allow skin darkening.With the development of the times, understanding increasingly diversification of the people to fashion, in vain It is not that the unique of beauty embodies, more and more people pursue bronze-colored or wheat skin.
Solarization sunbath is simplest natural beauty black method, but skin can be damaged by being excessively exposed to the sun, and And have found the skin that can lead to wrinkle, brown spot, pimple and cortex, relax.In the worst case, it is excessively exposed to Sunlight can cause have disfiguring or even fatefulue cutaneum carcinoma.Therefore, more and more U.S. black Related products come into being.
Common U.S. black product currently on the market, active constituent is chemically synthesized drug, such as dihydroxyacetone (DHA) (DHA), skin darkening can be made under conditions of being not exposed to sunlight.DHA is a kind of no sugar colour, can be with dead land for building Skin cell acts in the cuticula of epidermis.Skin Cell changes colour to obtain due to this effect tanned outer of the sun It sees.This color change just gradually subsides after typically lasting for about 5~7 days, and therefore, U.S. is black, and the effect is unsatisfactory.Also, have There is also certain risks for causing cutaneum carcinoma for a little chemically synthesized black products of U.S..
Quassia ketone (Nigakinone) is a kind of alkaloid, is quassia leaf (Ramulus et Folium Picrasmae) The bitter taste in the source of middle bitter taste, quassia leaf is even more stronger than quinine.Quassia leaf is commonly used as antipyretic and insecticide, and treatment The replenishers had a stomachache and stimulated appetite.
Astragaloside IV is the biologically active significant compound contained in a kind of common Chinese medicine-Radix Astragali.According to Theory of traditional Chinese medical science, " gas " is a kind of form of life energy, and Radix Astragali can then promote the cycle of " gas " in our body, therefore The Radix Astragali of different proportion can be added in this many famous ancient times Traditional Chinese medicinal prescription.
Quercetin -3- rhamnosides are the glucosides formed by flavonoids Quercetin and desoxysugar rhamnose, contain several phenol Base.Quercetin is a kind of inhibitor of nonspecific proteins kinases.
To so far, there are no the relevant reports applied in U.S. black product about Chinese medicine natural plants molecule.
Invention content
Based on this, the present invention provides a kind of new opplications of Chinese medicine natural plants molecule.
Specific technical solution is as follows:
Application of the Chinese medicine natural plants molecule in the product for preparing enhancing tyrosinase activity.
Chinese medicine natural plants molecule has effects that apply in U.S. black product in preparation.
Chinese medicine natural plants molecule described in some embodiments are selected from quassia ketone, Astragaloside IV and Quercetin -3- wherein At least one of rhamnoside.
In wherein some embodiments, the product is cosmetic products, drug or food.The cosmetic products being Cosmetic, the food can be food additives, beverage or nutrition fortifier.
Having effects that U.S. black cosmetics the present invention also provides a kind of.
Specific technical solution is as follows:
It is a kind of to have effects that U.S. black cosmetics, the active constituent in the cosmetics include Chinese medicine natural plants point Son, the Chinese medicine natural plants molecule are selected from least one of quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides.
Having effects that U.S. black drug the present invention also provides a kind of.
Specific technical solution is as follows:
A kind of to have effects that U.S. black drug, the active constituent in the drug includes Chinese medicine natural plants molecule, institute It states Chinese medicine natural plants molecule and is selected from least one of quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides.
Having effects that U.S. black food the present invention also provides a kind of.
Specific technical solution is as follows:
It is a kind of to have effects that U.S. black food, include Chinese medicine natural plants molecule in the food, the Chinese medicine is natural Plant molecular is selected from least one of quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides.
The present inventor has found that some Chinese medicine natural plants molecules can enhance tyrosine by lot of experiments Enzymatic activity can promote the generation of melanin, be finally reached the effect of colour of skin blackening, have U.S. black effect.Wherein, quassia ketone, Black effect of U.S. of Astragaloside IV and Quercetin -3- rhamnosides is the most notable.
Using Chinese medicine natural plants molecule as U.S. black effect ingredient, apply in cosmetic products (such as cosmetics), medicine Can substantially it lower because using chemical synthesis class tanning agent and excessive sun to bathe on product or food and other external application big health-oriented products of class The risk of cutaneum carcinoma caused by and, and U.S. black significant effect, have huge market potential.
Description of the drawings
Fig. 1 is the chemical constitution of Chinese medicine natural plants molecule quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides;
Fig. 2 is that the Chinese medicine natural plants molecule of the various concentration in embodiment 1 generates melanocyte the rush of melanin Into exercising result;
Fig. 3 is humidification knot of the Chinese medicine natural plants molecule to tyrosinase activity of the various concentration in embodiment 2 Fruit;
Fig. 4 is the schematic diagram for finding out Km and Vmax in enzyme reaction using Michaelis-Menten equation by double reciprocal plot;
Fig. 5 is humidification knot of the Chinese medicine natural plants molecule to tyrosinase activity of the various concentration in embodiment 2 The double reciprocal plot of fruit.
Specific implementation mode
Further details of theory is done to the new opplication of the Chinese medicine natural plants molecule of the present invention below in conjunction with specific embodiment It is bright.
1 B16 melanocyte melanins of embodiment generate experiment
1, prepare Chinese medicine natural plants molecular solution:
Following Chinese medicine natural plants molecule is weighed respectively:Quassia ketone, Astragaloside IV, Quercetin -3- rhamnosides, with DMSO It dissolves and is dissolved in 100mM surely;
The natural plants molecular solution of 100mM respectively with the pure water of Bioexperiment rank be diluted to 100 μM, 10 μM and 1 μM of natural plants molecular solution;
It will be respectively used to melanin production experiment test by diluted Chinese medicine natural plants molecular solution, while not have Solution (ratio of DMSO and water and the diluted Chinese medicine natural plants molecular solution phase of process of any natural plants molecule is added It is blank control together).Use 1nM α-melanocyte-stimulating hormone α-melanocyte stimulation hormone (α- MSH) it is used as positive control.
2, prepare B16 melanocytes:
B16 melanocytes (CRL-6323TM;ATCC, Manassas, VA) in 5%CO2With 37 DEG C under conditions of carry out Culture, culture medium Dulbecco's Modified Eagle'S Medium (DMEM, Invitrogen, Carlsbad, CA), And 10% fetal bovine serum albumin and Pen .- Strep (100U/mL) are supplemented in the culture medium.Only P8 to P18 it Between B16 melanocytes can be used for carrying out this experiment.In 4 days, melanocyte is containing ripe melanosome and can will be black In colouring matter secretion to culture medium, culture medium should be about 0.5-0.7 in the absorbance of 405nm, if melanocyte fails to reach This absorbance standard is considered as then the purpose for not being suitable for this experiment screening.
3, melanin production is tested:
B16 melanocytes are seeded on 96 well culture plates by each Kong Erwan, the training described in step 2 is added per hole Base 100 μ L are supported, and it includes quassia ketone, Astragaloside IV and Quercetin-to be separately added into 1 μM, 10 μM or 100 μM of step 1 preparation Chinese medicine natural plants molecular solution or placebo solution including 3- rhamnosides or 100 μ L of positive control solution, 5% CO2With 37 DEG C under conditions of cultivate 2-4 days.
The absorbance of the mixed solution after cultivating 2-4 days is directly detected at 405nm, and absorbance is converted into melanin Concentration.The result of experimental group is compared with blank control group, the melanin concentration of experimental group is converted into blank control group Melanin concentration multiple, the results are shown in Figure 2.As can be seen from Figure:100 μM of quassia ketone, Astragaloside IV and Quercetin -3- rhamnoside molecular solution has the effect of significantly promoting melanin production.
2 tyrosinase activity of embodiment is tested
1, prepare Chinese medicine natural plants molecular solution:
Following Chinese medicine natural plants molecule is weighed respectively:Quassia ketone, Astragaloside IV, Quercetin -3- rhamnosides, with DMSO It dissolves and is dissolved in 100mM surely;
The natural plants molecular solution of 100mM respectively with the pure water of Bioexperiment rank be diluted to 100 μM, 10 μM and 1 μM of natural plants molecular solution;
Tyrosinase activity effect test will be respectively used to by diluted Chinese medicine natural plants molecular solution, while not have There are solution (ratio of DMSO and water and the diluted Chinese medicine natural plants molecular solution phase of process that any natural plants molecule is added It is blank control together).
2, tyrosinase activity is tested:
Tyrosinase activity test is carried out according to a conventional method.Tyrosinase activity test is screening whitening or U.S. black powder product Conventional test methodologies.Tyrosine can be converted to levodopa (L-DOPA) because of the effect of tyrosinase, and it is more to be then converted into Bar pigment (Dopachrome).Dopachrome has absorbance under 492nm wavelength, so can quantify and calculate tyrosinase Activity.Dopachrome only keeps in object, it can be converted to melanin (Melanin).Melanin on human skin is by black Dopachrome caused by plain cell (Melanocytes) is transformed.Melanin can be gradually in melanocyte Ripe in melanosome (Melanosome), melanosome will turn along the dendron (Dentrite) of melanocyte after maturation Horn cell (Keratinocytes) is moved on to, the colour of skin is made to deepen.Dopachrome and melanin can be reduced by inhibiting tyrosinase activity Generation, so that the colour of skin is become lighter whiter.Conversely, enhancing tyrosinase activity can be effectively increased the production of dopachrome and melanin It is raw, to make the colour of skin become deeper more black.
Since tyrosinase can convert tyrosine to dopachrome, in the test, dopachrome production quantity It is higher, illustrate that natural plants molecular solution is better to the stimulation of tyrosinase, the activity of tyrosinase is higher.Test result (enhancing rate of each experimental group relative to blank control group) as shown in Figure 3.From Fig. 3 results:Quassia ketone, the Huang of various concentration The solution of stilbene first glycosides and Quercetin -3- rhamnosides, has tyrosinase different degrees of stimulation, wherein 100 μM of hardship The wooden ketone, Astragaloside IV and Quercetin -3- rhamnosides molecular solution can significantly increase the activity of tyrosinase.
How using Michaelis-Menten equation the Km and Vmax in enzyme reaction are found out by double reciprocal plot displaying (see attached drawing 4).From The natural plants molecule of various concentration makees double reciprocal plot to the result of tyrosinase humidification, then find out opposite Km and Vmax can know humidification is which kind of belongs to using these Km and Vmax with the variation of natural plants molecular concentration Mechanism.As shown in figure 5, in stimulation by double reciprocal plot from the natural plants molecule of various concentration to tyrosinase, It was found that as the Vmax in the increase tyrosinase reaction of natural plants molecular concentration starts to increase and the then constant (Non- of Km Competitive is noncompetitive).The constant normal knots for illustrating natural plants molecule and not interfering with tyrosine and tyrosinase of Km It closes, and Vmax indicates that natural plants molecule can enhance the work that tyrosinase converts tyrosine as natural plants molecular concentration increases Property.The mechanism of action that the mechanism is significantly followed by the α-MSH of carcinogenic risk is completely different.α-MSH are the letters by cell merely Road increases the expression number of tyrosinase, and natural plants molecule is then the transformation efficiency for enhancing tyrosine.Therefore, natural to plant Object molecule has very big potential development at the safe black product of U.S..
It is by above-mentioned experiment it is found that of the present invention including quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides Natural plants molecule can be played the role of by the stimulation to tyrosinase it is U.S. black.It is black to can be used for preparing various U.S.s Product.
Inventor further analyzes Astragaloside IV and Quercetin -3- rhamnosides may be such as with the reason of U.S. black effect Under:Radix Astragali can inhibit degradation of the hypoxia-inducible factor-1 alpha (HIF-1 α) under normal oxygen environment, and lead to the accumulation of HIF-1 α, cause Cell generates a false micro-environmental hypoxia.And the melanocyte of skin epidermis substrate is deposited on always situated in multilayer skin In most anoxic region, melanocyte in the micro-environmental hypoxia of skin can pass through HIF-1 α and Akt accesses promote melanocyte It generates.Astragaloside IV may be by inhibiting the activity of HIF-1 α degradations in melanocyte to generate false micro-environmental hypoxia, then Increase in melanocyte the generation of melanin by the channels Akt- by reaches U.S. black effect.
Quercetin possesses the ability of activation estrogen receptor, and activation estrogen receptor may be with Quercetin -3- rhamnosides U.S. black effect it is related because tyrosinase is to keep skin U.S. black through melanin production, and the channels Wnt- are one of them The channel of tyrosinase expression is controlled, the receptor Frizzled of Wnt- channels is one of estrogen receptor again.Therefore, May be relevant property between Quercetin -3- rhamnosides, the channels Wnt- and U.S. black effect three.
Application of the Chinese medicine natural plants molecule disclosed in this invention in U.S. black effect, compared with traditional U.S. black method, The risk of cutaneum carcinoma caused by due to using chemical synthesis class tanning agent and excessive sun to bathe can substantially be lowered.In addition, raw material at Originally it substantially reduces, so as to reduce product price, can be widely used in drug, health products, food and beauty product, have huge Big market potential.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.

Claims (7)

1. application of the Chinese medicine natural plants molecule in the product for preparing enhancing tyrosinase activity.
2. Chinese medicine natural plants molecule has effects that apply in U.S. black product in preparation.
3. application according to claim 1 or 2, which is characterized in that the Chinese medicine natural plants molecule is selected from quassia ketone, Huang At least one of stilbene first glycosides and Quercetin -3- rhamnosides.
4. application according to claim 1 or 2, which is characterized in that the product is cosmetics, drug or food.
5. a kind of having effects that U.S. black cosmetics, which is characterized in that the active constituent in the cosmetics includes Chinese medicine day Right plant molecular, the Chinese medicine natural plants molecule in quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides at least It is a kind of.
6. a kind of having effects that U.S. black drug, which is characterized in that the active constituent in the drug includes that Chinese medicine is naturally planted Object molecule, the Chinese medicine natural plants molecule in quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides at least one Kind.
7. a kind of having effects that U.S. black food, which is characterized in that include Chinese medicine natural plants molecule in the food, it is described Chinese medicine natural plants molecule is selected from least one of quassia ketone, Astragaloside IV and Quercetin -3- rhamnosides.
CN201710224429.2A 2017-04-07 2017-04-07 The new opplication of Chinese medicine natural plants molecule Withdrawn CN108685744A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116549469A (en) * 2023-02-27 2023-08-08 中国科学院新疆理化技术研究所 Application of flavonoid compound quercetin-3-O- (6' -caffeoyl) -beta-D-glucoside

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103058974A (en) * 2012-11-26 2013-04-24 中国人民解放军军事医学科学院毒物药物研究所 Natural compound and preparation method and application thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103058974A (en) * 2012-11-26 2013-04-24 中国人民解放军军事医学科学院毒物药物研究所 Natural compound and preparation method and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GALLANT K. L. CHAN等: "A High Throughput Screening Platform for Skin Tuning Properties from Natural Products: Identification of Skin Tanning Compounds", 《JOURNAL OF COSMETICS, DERMATOLOGICAL SCIENCES AND APPLICATIONS》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116549469A (en) * 2023-02-27 2023-08-08 中国科学院新疆理化技术研究所 Application of flavonoid compound quercetin-3-O- (6' -caffeoyl) -beta-D-glucoside

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