CN108671087A - 一种治疗酒渣鼻的药物组合物及其制备方法和用途 - Google Patents
一种治疗酒渣鼻的药物组合物及其制备方法和用途 Download PDFInfo
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Abstract
本发明公开了一种治疗酒渣鼻的药物组合物，它是由下述重量配比的原料药制备而成的制剂：枇杷叶15‑20份、黄芩10‑15份，黄连10‑15份，甘草6‑9份，桑白皮12‑15份，苦楝皮10‑15份，苦参10‑15份，白鲜皮10‑15份，马鞭草10‑12份。实验结果说明，本发明药物组合物，配伍精当，各药味相辅相成，对治疗酒渣鼻疗效显著，并且毒副作用小，用法简单，易被患者接受，具备广阔的市场应用前景，为临床治疗提供了新的选择。
Description
技术领域
本发明涉及一种治疗酒渣鼻的药物组合物及其制备方法和用途。
背景技术
酒渣鼻又名玫瑰痤疮，是一种主要发生在面中部，以毛细血管扩张及红丘疹和脓疱疹为主要表现的慢性皮肤疾病，常伴有面部干燥、瘙痒、灼热、刺痛等不适症状，最早累及鼻、面颊、下颌、前额和眉间，是皮肤科常见疾病。因鼻部颜色紫红如酒渣而命名，好发于中年人，女性较多。本病可分为三期，包括红斑期、丘疹脓疱期和鼻赘期，其中红斑型最为多见。
现代医学对其发病机理仍不甚明确，通常认为与局部血管舒缩神经失调导致毛细血管长期扩张有关，紫外线照射、遗传以及局部反复感染是其发病的重要因素，嗜酒、辛辣刺激、高温及寒冷刺激、情绪激动、内分泌障碍也是其加重的诱因。西医治疗多以抗感染、诱导血管收缩为主要治法。但因该病进展缓慢，病程长且易反复，患者难以坚持，西医治疗不甚理想。中医治疗酒渣鼻疗效显著，并且毒副作用小，用法简单，易被患者接受。而目前未见将枇杷叶、黄芩、黄连、甘草、桑白皮、苦楝皮、苦参、白鲜皮、马鞭草用于治疗酒渣鼻的报道。
发明内容
本发明的目的在于提供了一种治疗酒渣鼻的药物组合物，它是由下述重量配比的原料药制备而成的制剂：
枇杷叶15-20份、黄芩10-15份，黄连10-15份，甘草6-9份，桑白皮12-15份，苦楝皮10-15份，苦参10-15份，白鲜皮10-15份，马鞭草10-12份。
进一步地，它是由下述重量配比的原料药制备而成的制剂：
枇杷叶15份、黄芩10份、黄连10份、甘草6份、桑白皮12份、苦楝皮10份、苦参15份、白鲜皮10份、马鞭草10份。
进一步地，它是由原料药的药粉、原料药的水或有机溶剂提取物为活性成分，加上药学中可接受的辅料制备而成的制剂。
进一步地，所述制剂为外用制剂。
进一步地，所述外用制剂为敷贴、糊剂、膏剂。
进一步地，所述外用制剂为敷贴。
本发明提供了一种制备上述药物组合物的方法，它包括以下步骤：
(1)按重量配比称取各原料药；
(2)取原料药的药粉、水或有机溶剂提取物，加上药学中可接受的辅料或辅助性成分制备成制剂。
进一步地，它包括以下步骤：
(1)按重量配比称取各原料药；
(2)取原料药的药粉，用水将原料药的药粉调成糊状即可。
本发明还提供了上述药物组合物在制备治疗酒渣鼻的药物中的用途。
枇杷叶清泻肺胃积热，为君药。黄芩、黄连、苦楝皮清热燥湿、泻火解毒。桑白皮、苦参清热泻火、燥湿杀虫、利尿，使火邪从小便而去。白鲜皮清热燥湿、祛风解毒，马鞭草活血散瘀、截疟解毒，共为臣药。现代药理研究认为苦参可平衡油脂分泌，疏通并收敛毛孔，清除皮肤内毒素；白鲜皮有抗菌作用；马鞭草能抗炎止痛。生甘草清热解毒，调和诸药，为佐药。全方共奏清热燥湿，泻火解毒之功。
实验结果说明，本发明药物组合物，配伍精当，各药味相辅相成，对治疗酒渣鼻疗效显著，并且毒副作用小，用法简单，易被患者接受，具备广阔的市场应用前景，为临床治疗提供了新的选择。
显然，根据本发明的上述内容，按照本领域的普通技术知识和惯用手段，在不脱离本发明上述基本技术思想前提下，还可以做出其它多种形式的修改、替换或变更。
以下通过实施例形式的具体实施方式，对本发明的上述内容再作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
具体实施方式
实施例1、本发明药物组合物的制备
处方：枇杷叶15g，黄芩10g，黄连10g，生甘草6g，桑白皮12g，苦楝皮10g，苦参15g，白鲜皮10g，马鞭草10g。
制备方法：取上述原料药，粉碎成药粉，加水调成糊状即可。
使用方法，将制备好的糊状药物涂于纱布后敷于鼻部后用胶布固定。
实施例2、本发明药物组合物的制备
处方：枇杷叶20g，黄芩15g，黄连15g，生甘草9g，桑白皮15g，苦楝皮15g，苦参10g，白鲜皮15g，马鞭草12g。
制备方法：取上述原料药，粉碎成药粉，加水调成糊状即可。
使用方法，将制备好的糊状药物涂于纱布后敷于鼻部后用胶布固定。
以下通过试验例的方式来说明本发明的有益效果。
试验例1、临床病例统计
(1)收治患者标准
酒渣鼻患者40例，其中女33例、男7例，病程1月-1年。
(2)诊断标准
中医标准：
参照《中华人民共和国中医药行业标准·中医皮肤科病证诊断疗效标准》制定的诊断标准
①鼻头或鼻两侧多呈红斑丘疹。临床一般分三期：红斑期主要是潮红毛细血管扩张；丘疹期是在潮红的基础上出现散在米粒大小丘疹或掺杂小脓疮，但无粉刺；鼻赘期为晚期，鼻尖出现结节、肥大增生，表面凹凸不平如鼻赞。一般无自觉不适症状。
②在面部常见五点分布，鼻尖、两眉间、下领部、鼻唇沟等。
③多见于面部油脂分泌较多的人，常有便秘习惯。
④组织病理检査主要见毛细血管扩张，皮脂腺増生。或可见结缔组织和皮脂腺增殖肥大。
西医诊断：
参考美国国家玫瑰痤疮协会专家委员会(NRSEC)提出的玫瑰痊疮诊断标准：必须包含以下一项或一项以上主要症状：
①阵发性潮红
②持久性性红斑
③丘疼和脈疮
④毛细血管扩张；
包含下一项或一项以上次要症状更加支持诊断：
①烧灼或刺痛感(尤其是颧部)
②斑块
③皮肤干燥
④水肿
⑤眼部表现
⑥面部外周累及
⑦肥大增生性改变
(3)治疗标准
症状分级(量化指标)轻:颜面中部特别是鼻尖部出现红斑，开始时为暂时性，时起时消，寒冷、饮酒、进食辛辣刺激性食物及精神兴奋时红斑更为明显，伴有毛细血管扩张。中:出现痤疮样丘疹或小脓疱，但无明显的黑头粉刺形成。毛细血管扩张更为明显，如红丝缠绕，纵横交错，皮色由鲜红变为紫褐，自觉轻度瘙痒。重:鼻部结缔组织增生，皮脂腺异常增大，致鼻尖部肥大，形成大小不等的结节状隆起。皮肤增厚，表面凹凸不平，毛细血管扩张更加明显。
主要症状体征：观察毛细血管扩张、皮色、丘疹、脓疱、结节症状,按无、轻、中、重分层标准,分别计0、2、4、6分。以尼莫地平法计算证候积分。证候积分率＝(治疗前总积分-治疗后总积分)/治疗前总积分×10 0％。
疗效标准参照《中药新药临床研究指导原则(试行)》
临床痊愈:中医临床症状、体征消失或基本消失,证候积分率≥95％。
显效:中医临床症状、体征明显改善，70％≤证候积分率<95％。
有效:中医临床症状、体征均有好转，30％≤证候积分率<70％。
无效:中医临床症状、体征均无明显改善,甚或加重,证候积分率不足30％。
(4)治疗方法
①给药方法：诊断明确后，治疗组患者均采用药物贴敷患处进行治疗：
枇杷叶15g，黄芩10g，黄连10g，生甘草6g，桑白皮12g，苦楝皮10g，苦参15g，白鲜皮10g，马鞭草10g。上述原料药，粉碎成药粉，加水调成糊状，涂敷于鼻部，胶布固定。
治疗前仔细询问患者病史，有皮肤过敏者，不宜采用刺激性较强的药物。辩证用药方能提高疗效。治疗轻症，每日早晚各敷一次，每次敷30min。然后清水洗净，病愈则去药；中度或重度用药，病愈后每日夜间敷一次，每次敷30min，维持治疗2周。治疗中出现不良反应，如疼痛、过敏反应、病情加重等，应立即去药。
对照组：维A酸加甲硝唑治疗。
②无明显用药禁忌。
(5)治疗结果
治疗时间：连续治疗3个月
疗效判定：治疗后观察患者酒渣鼻症状是否减轻，有无不良反应。
治疗效果：如下所示
表1两组患者治疗后疗效比较
| 组别 | N | 痊愈 | 明显 | 有效 | 无效 | 显愈率 |
| 治疗组 | 20 | 12 | 6 | 1 | 1 | 90％* |
| 对照组 | 20 | 8 | 4 | 2 | 6 | 60％ |
*表示与对照组比较,P<0.05
由上述结果可知，治疗组显愈率90％，对照组显愈率60％，；治疗组疗效优于对照组。
综上所述，本发明药物组合物，配伍精当，各药味相辅相成，对治疗酒渣鼻疗效显著，并且毒副作用小，用法简单，易被患者接受，具备广阔的市场应用前景，为临床治疗提供了新的选择。
Claims (9)
1.一种治疗酒渣鼻的药物组合物，其特征在于：它是由下述重量配比的原料药制备而成的制剂：
枇杷叶15-20份、黄芩10-15份，黄连10-15份，甘草6-9份，桑白皮12-15份，苦楝皮10-15份，苦参10-15份，白鲜皮10-15份，马鞭草10-12份。
2.根据权利要求1所述的药物组合物，其特征在于：它是由下述重量配比的原料药制备而成的制剂：
枇杷叶15份、黄芩10份、黄连10份、甘草6份、桑白皮12份、苦楝皮10份、苦参15份、白鲜皮10份、马鞭草10份。
3.根据权利要求1或2所述的药物组合物，其特征在于：它是由原料药的药粉、原料药的水或有机溶剂提取物为活性成分，加上药学中可接受的辅料制备而成的制剂。
4.根据权利要求1～3任一项所述的药物组合物，其特征在于：所述制剂为外用制剂。
5.根据权利要求4所述的药物组合物，其特征在于：所述外用制剂为敷贴、糊剂、膏剂。
6.根据权利要求5所述的药物组合物，其特征在于：所述外用制剂为敷贴。
7.一种制备权利要求1～6任一项所述药物组合物的方法，其特征在于：它包括以下步骤：
(1)按重量配比称取各原料药；
(2)取原料药的药粉、水或有机溶剂提取物，加上药学中可接受的辅料或辅助性成分制备成制剂。
8.根据权利要求7所述的方法，其特征在于：它包括以下步骤：
(1)按重量配比称取各原料药；
(2)取原料药的药粉，用水将原料药的药粉调成糊状即可。
9.权利要求1～6任一项所述药物组合物在制备治疗酒渣鼻的药物中的用途。
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