CN108653586A - A kind of Chinese medicine composition is preparing the application in treating anti-parkinson drug - Google Patents
A kind of Chinese medicine composition is preparing the application in treating anti-parkinson drug Download PDFInfo
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- CN108653586A CN108653586A CN201810686303.1A CN201810686303A CN108653586A CN 108653586 A CN108653586 A CN 108653586A CN 201810686303 A CN201810686303 A CN 201810686303A CN 108653586 A CN108653586 A CN 108653586A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8988—Gastrodia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention relates to a kind of application of Chinese medicine composition in preparing treatment anti-parkinson drug, which is made of the bulk pharmaceutical chemicals of following weight ratio：5 25 parts of Rhizoma Chuanxiong, 1.5 8 parts of Rhizoma Gastrodiae.The Chinese medicine composition compatibility is simple, and preparation method is easy, has exact effect to treatment Parkinson's disease.
Description
Technical field
Present invention relates generally to the field of Chinese medicines, and in particular to Chinese medicine composition is preparing answering in treating anti-parkinson drug
With.
Background technology
Parkinson's disease (PD) is a kind of using nigro-striatal pathway nerve retrograde affection as the nervous system of main feature
Degenerative disease, Clinical symptoms are mainly shown as static tremor, muscle rigidity, bradykinesia and postural balance obstacle, and often
With cognition dysfunction.In 60 years old or more crowds, PD incidence is about 1%~2%, is seriously affect human health second
Big neurodegenerative disease.(Zhang Xue, Zhang Wen, Du Lida, Koryo, Du Guan China antiparkinsonism drugs and its action target spot research
[J] the Inpharms that are in progress study magazine, 2016,43 (01):87-96.)
Currently, being clinically all made of symptomatic treatment to PD, it there is no effective treatment means that can restore denatured neurons.From
Since levodopa asks city within 1967, levodopa has become the primary treatment drug of PD motor symptoms.From current clinic
From the point of view of, it there is no other dopamine receptor (DR) agonists that can reach the clinical effectiveness of levodopa, which is praised
It is the basic medication of PD for " goldstandard " of PD treatments.But levodopa is used for a long time can cause motor fluctuations, on-off phenomenon again
And the side effects such as dyskinesia.
The compound preparation of the mainly levodopa of clinical application, in order to improve levodopa treatment effect, subtract
Few dosage is to mitigate adverse reaction.Such as the peripheries such as levodopa and carbidopa decarboxylase inhibitors share, or with gold
The rigid anticholinergic agents such as alkanamine and benzhexol share.(Zhang Xue, Zhang Wen, Du Lida, Koryo, Du Guan China antiparkinsonism drugs and its
Action target spot progress [J] Inpharms study magazine, 2016,43 (01):87-96.)
Invention content
The purpose of the present invention is to provide a kind of Chinese medicine compositions in the application for preparing treatment anti-parkinson drug.
The present invention provides a kind of Chinese medicine compositions to prepare the application in treating anti-parkinson drug, wherein in described
Drug composition is made of the bulk pharmaceutical chemicals of following weight ratio：5-25 parts of Rhizoma Chuanxiong, 1.5-8 parts of Rhizoma Gastrodiae.Wherein, Rhizoma Chuanxiong is umbrella shape
The dry rhizome of section plant Rhizoma Chuanxiong Ligusticum chuanxiong Hort.；Rhizoma Gastrodiae is orchid Rhizoma Gastrodiae Gastrodia
The dry tuber of elata Bl..The Chinese medicine composition also may also include the auxiliary material that drug is received.
Preferably, according to application above-mentioned, wherein the Chinese medicine composition is by the bulk pharmaceutical chemicals system of following weight ratio
At：8-15 parts of Rhizoma Chuanxiong, 2-6 parts of Rhizoma Gastrodiae.
Preferably, according to application above-mentioned, wherein the Chinese medicine composition is by the bulk pharmaceutical chemicals system of following weight ratio
At：10 parts of Rhizoma Chuanxiong, 2.5 parts of Rhizoma Gastrodiae.
Preferably, according to application above-mentioned, wherein the Chinese medicine composition is by the bulk pharmaceutical chemicals system of following weight ratio
At：9 parts of Rhizoma Chuanxiong, 5 parts of Rhizoma Gastrodiae.
It is highly preferred that according to application above-mentioned, wherein the preparation formulation of the Chinese medicine composition be capsule, tablet,
Granula, powder, oral solution or pill.
It is further preferred that according to application above-mentioned, wherein the preparation method of the Chinese medicine composition includes：
(1) Rhizoma Chuanxiong 5-25 is pressed, Rhizoma Gastrodiae 1.5-8 weight ratio takes two kinds of Rhizoma Chuanxiong, Rhizoma Gastrodiae components, is dried, crushes, mixes
Obtain mixture；
(2) it uses 70%-90% alcohol refluxs to extract the mixture and obtains extracting solution and the dregs of a decoction 2-3 time, it is 1-3 hours each；
(3) merge the extracting solution, filter to get filtrate；
(4) filtrate is concentrated into the clear cream that 55-65 DEG C of relative density is 1.21-1.30.
More preferably, according to application above-mentioned, wherein the preparation method of the Chinese medicine composition further includes：
(5) dregs of a decoction are decocted 1-2 hours with water, collecting decoction, filtering, and the filtrate after the decocting liquid is concentrated into 55-65
DEG C relative density is the clear cream of 1.21-1.30, is preferably decocted 1 hour；
(6) merge clear cream obtained by step (4) and step (5).
More preferably, according to application above-mentioned, wherein the weight ratio of Rhizoma Chuanxiong and Rhizoma Gastrodiae is 10-25 in step (1)：1.5-
8。
More preferably, according to application above-mentioned, wherein step (2) is to extract the mixture 2 using 90% alcohol reflux
Secondary extracting solution, 2 hours every time.
Or more preferably, according to application above-mentioned, wherein the relative density of clear cream obtained by step (4) and/or step (5)
It is 1.27.
The capsule preparation method thereof of the Traditional Chinese drug mixture further includes in addition to above-mentioned steps：Step (4) and/or step (5)
The auxiliary material that drug receives, such as appropriate dextrin is added in gained clear cream, and vacuum drying is mixed evenly, and is sieved, granulation, and whole grain fills glue
Capsule.
For Chinese medicine composition of the present invention by 2 taste Chinese medicinal composition of Rhizoma Chuanxiong and Rhizoma Gastrodiae, compatibility is simple, and preparation method is easy, the Chinese medicine
Composition has promoting blood circulation soothing the liver, the effect of removing obstruction in channels to relieve pain.
Inventor is in clinical practice it was unexpectedly observed that this Chinese medicine composition has very good anti-Parkinson effect, invention
People has carried out pharmacodynamic study to the medicine, it was demonstrated that its is curative for effect.
Experimental study shows that Chinese medicine composition of the invention can significantly improve MPTP modeling mice behavior abnormal symptoms,
There is apparent inhibition to mouse circling behavior, shorten the mouse pole-climbing time and mouse hanging capacity can be increased, caused by MPTP
The damage of mouse movement function has certain protective effect；Increase mouse striaturn DA, DOPAC, HVA content, having improves
The effect of DA contents in PD animal corpus straitums；Neurotransmitter is significantly adjusted, protection 6-OHDA causes neuronal cell injury.Effect with
Positive control drug Madopar is similar, prompts the Chinese medicine composition that will play a significant role in terms for the treatment of or preventing Parkinson.
Specific implementation mode
The invention discloses a kind of application of Chinese medicine composition, those skilled in the art can use for reference present disclosure, suitably
Modified technique parameter is realized.In particular, it should be pointed out that all similar substitutions and modifications are for a person skilled in the art
It will be apparent that they are considered as being included in the present invention.The method of the present invention and application are carried out by preferred embodiment
Description, related personnel obviously can not depart from the content of present invention, in spirit and scope to method described herein and application into
Row change is suitably changed and is combined, to realize and apply the technology of the present invention.
As it is used herein, term " treatment " refer to it is any treat or improve damage, symptom, illness or symptom (for example,
Pain) on success indicator, including any parameter either objectively or subjectively such as eliminates；It improves；Symptom reduces or patient is made more
Endure symptom, damage, symptom or illness；Reduce symptom or illness frequency or duration；Alternatively, in some cases, preventing
The breaking-out of symptom or illness.The treatment or improvement of symptom can be based on any either objectively or subjectively parameter, including, such as physical examination
Result.
Following embodiments are raw materials used and reagent is available on the market.
The preparation of 1 Chinese medicine composition of embodiment
Rhizoma Chuanxiong 784g, Rhizoma Gastrodiae 196g are taken, is dried, crushes, mixes；Then being extracted 2 times with 90% alcohol reflux must carry
Liquid and the dregs of a decoction are taken, 2 hours every time, merges extracting solution, filters to get filtrate；It is 1.27 that filtrate, which is concentrated into 55-65 DEG C of relative density,
Clear cream；Dregs of a decoction water decocts 2 times, 1 hour every time, collecting decoction, filtering, the filtrate after decocting liquid be concentrated into 55-65 DEG C it is relatively close
The clear cream that degree is 1.27；Merge with above-mentioned clear cream；The auxiliary material that drug receives is added, vacuum drying is mixed evenly, is sieved；Granulation,
Whole grain, it is encapsulated, be made 1000 it is spare, every capsule loading amount is 0.34g, is equivalent to crude drug 0.98g.
Effect study of 2 Chinese medicine composition of embodiment to mouse Parkinson's model
1, experiment material
Given the test agent title：The Chinese medicinal composition capsules content prepared according to the method for embodiment 1；
Positive control drug：Madopar, specification：Levodopa 200mg or benserazide 50mg, Chinese medicines quasi-word H10930198, on
Extra large Co., Ltd of Roche Group production；
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (Sigma Co., USA)；
SPF grades of C57BL/6 male mices, weight 20-25g are provided by Beijing dimension tonneau China Experimental Animal Center, and production is permitted
It can the number of card：SCXK (capital) 2016-0011.
2, experimental method
It is prepared by Parkinson's disease (PD) mouse model：Mouse is randomly divided into 6 groups, respectively Normal group, model comparison
The high, medium and low dosage group of group, Chinese medicinal composition capsules, Madopar group.The high, medium and low dosage group of Chinese medicinal composition capsules presses agent respectively
Measure 3.0g/kg, 1.5g/kg, 0.75g/kg gavage 21d, Madopar group according to dosage 2.8mg/kg gavages, Normal group and model
Control group distinguishes gavage aliquots of deionized water.Modeling in the 22nd day is administered, model control group, Chinese medicinal composition capsules are high, medium and low
MPTP, dosage 72g/kg is injected intraperitoneally in dosage group and Madopar group, divides 4 times and has beaten, per minor tick 2h, Normal group abdominal cavity
Normal saline is injected, behaviouristics index test is carried out after injecting MPTP0.5h.
3, observation index
3.1 Behavior test
3.1.1 rotation test：The circling behavior of mouse, per injection MPTP are observed in the plastic tub of a diameter of 50cm
After 30 minutes, it is observed continuously 30 minutes, records the number of revolutions of mouse.
3.1.2 Grasping clubglass test：The plastic beads of one a diameter of 2.5cm is fixed on to the wood of a diameter of 1cm of root long 50cm
Bar top twines layer gauze with anti-slip on rod.Mouse is put into top dome, records following 3 times：1. mouse has climbed bar length
The time required to top half；2. mouse has climbed the time needed for the lower half portion of bar length；3. mouse has climbed needed for the overall length of bar length
Time.By following scale：Above-mentioned a certain action is completed in 3 seconds and remembers 2 points of completion note in 3 points, 6 seconds, and 1 point was remembered more than 6 seconds.3
A time score summation is tested mouse Grasping clubglass test score.
3.1.3 suspension experiment：The double forelimbs of mouse are hung on a horizontal metal wire, as mouse catches metal with double hind legs
Line remembers 3 points；Only metal wire is caught to remember 2 points with a hind leg；Two hind legs fail to grip with 1 point of note；Mouse, which falls, is denoted as 0 point.
3.2 detection dopamine (DA) contents
Mouse broken end sacrificed by exsanguination, takes mouse brain striatum, in -80 DEG C of preservations, for measuring DOPAMINE CONTENT IN RABBIT.
4 results
4.1 general behaviors are observed
PD model groups mouse in the 1st injection (MPTP) occur within 5-15 minutes afterwards it is different degrees of tremble, perpendicular hair, bow
The back of the body, movement reduce, erect the symptoms such as tail, and Normal group does not occur above-mentioned behaviouristics variation, also behavior without spin；With model comparison
Group compares, and Chinese medicinal composition capsules are high, middle dose group can improve above-mentioned behaviouristics symptom, have to mouse circling behavior and obviously change
It is kind, shorten the mouse pole-climbing time and the scoring of mouse hanging capacity, P can be increased<0.01, P<0.05.It is shown in Table 1,2,3.
Influence of 1 Chinese medicinal composition capsules of table to mouse pole-climbing ability
The * P compared with model control group<0.05, * * P<0.01
Influence of 2 Chinese medicinal composition capsules of table to mouse circling behavior
The * P compared with model control group<0.05, * * P<0.01
3 Chinese medicinal composition capsules of table hang mouse the influence of behavior
The * P compared with model control group<0.05, * * P<0.01
The influence of DA and its metabolite in 4.2 pairs of mouse striaturns
The DA of model control group, DOPAC (3,4-Dihydroxyphenylacetic acid), the content of HVA (homovanillic acid) are more normally organized pair
(P is decreased significantly according to group<0.01), compared with model group, Chinese medicinal composition capsules are high, middle dose group DA contents have not
Increase (P with degree<0.01).It is shown in Table 4.
Influence of 4 Chinese medicinal composition capsules of table to mouse DA and HVA content
The * P compared with model control group<0.05, * * P<0.01
As a result show that the high, medium and low dosage of this Chinese medicinal composition capsules can significantly improve MPTP mice behavior abnormal symptoms,
There is apparent inhibition to mouse circling behavior, shorten the mouse pole-climbing time and mouse hanging capacity can be increased, increases mouse striaturn
DA, DOPAC, HVA content, and have dose-dependence, effect is similar to positive control drug Madopar, prompts this Chinese traditional medicine composition
Composite capsule has the pharmacodynamic basis for treating or preventing Parkinson.
3 Chinese medicine composition of embodiment causes neuronal cell injury experimental study to 6-OHDA
1, experiment material
Given the test agent title：This Chinese medicinal composition capsules content；Clonal Rat Pheochromocytoma tumor PC12 cell strains, 6-
OHDA is purchased from Sigma Co., USA, and MTT is purchased from Biosharp, and DMEM high glucose mediums are purchased from Hyclone, newborn bovine serum purchase
From Hyclone.
2, experimental method：
2.1 cell culture
PC12 cell inoculations are cultivated in culture bottle, and culture solution is the DMEM high sugar cultures containing 15% calf serum
Base is placed in 37 DEG C, 5%CO2Under the conditions of cultivate in incubator, change liquid every other day, after single-layer culturing cell 80% converges, use
0.25% trypsin digestion adds the culture medium containing serum to terminate digestion, and piping and druming becomes single cell suspension, by PC12 cell concentrations
It adjusts to 1xl05/ mL is inoculated in 96 orifice plates, per 100 μ L of hole, is placed in 37 DEG C, 5%CO2It is cultivated under the conditions of incubator.
The determination of activity of 2.2 pairs of 6-OHDA induction PC12 cellular damages
After cell adhere-wall culture 3 days, it is divided into blank control group, model control group, Madopar group (0.02mg/L), Chinese medicine
The high, medium and low dosage group of composition capsule (400,200,100mg/L).Wherein blank control group and model control group are not added with any
Drug, remaining each group adds the culture solution cultures of the Chinese medicinal composition capsules containing various concentration, and remaining is each in addition to blank control group afterwards for 24 hours
Group is separately added into a concentration of 100 μm of ol/L 6-OHDA, and equivalent PBS is added in blank control group, and every group of 10 multiple holes, effect is for 24 hours
Afterwards, 4 μ l MTT solution (5mgmL are added per hole-1), it is placed in 37 DEG C of constant temperature, contains 5%CO2Incubator in be further cultured for 4h,
Culture solution in hole is carefully sucked after centrifugation, and 150 μ L DMSO are added per hole, gently shaking 10min makes crystal fully dissolve,
The light absorption value that each hole is detected at microplate reader OD 490nm, calculates the inhibiting rate of cell.
5 Chinese medicinal composition capsules of table are on the active influence on 6-OHDA induction PC12 cellular damages
The * P compared with model control group<0.05, * * P<0.01
5 result of table shows that the high, medium and low dosage group of this Chinese medicinal composition capsules has centainly the PC12 cells that 6-OHDA is damaged
Protective effect, present dose-dependence, effect is similar to positive control drug Madopar, prompt this Chinese medicinal composition capsules tool
There is anti-Parkinson's disease.
The present invention is also prepared for the Chinese medicine composition of different weight proportioning, such as Rhizoma Chuanxiong respectively：Rhizoma Gastrodiae is 9：5, Rhizoma Chuanxiong：It
Fiber crops are 8：2, Rhizoma Chuanxiong：Rhizoma Gastrodiae is 15：6.It is found by above-mentioned identical experiment technique study：The Chinese medicine composition of these different ratios is equal
MPTP modeling mice behavior abnormal symptoms can be significantly improved, have apparent inhibition to mouse circling behavior, shorten mouse pole-climbing
Time simultaneously can increase mouse hanging capacity；Increase mouse striaturn DA, DOPAC, HVA content.It is thin to the PC12 of 6-OHDA damages
Born of the same parents have certain protective effect.
Finally it should be noted that：Obviously, the above embodiment is merely an example for clearly illustrating the present invention, and simultaneously
The non-restriction to embodiment.For those of ordinary skill in the art, it can also do on the basis of the above description
Go out other various forms of variations or variation.There is no necessity and possibility to exhaust all the enbodiments.And thus drawn
The obvious changes or variations that Shen goes out are still in the protection scope of this invention.
Claims (10)
1. a kind of Chinese medicine composition is preparing the application in treating anti-parkinson drug, which is characterized in that the Chinese medicine composition
It is made of the bulk pharmaceutical chemicals of following weight ratio：5-25 parts of Rhizoma Chuanxiong, 1.5-8 parts of Rhizoma Gastrodiae.
2. application according to claim 1, which is characterized in that the Chinese medicine composition is by the original of following weight ratio
Material medicine is made：8-15 parts of Rhizoma Chuanxiong, 2-6 parts of Rhizoma Gastrodiae.
3. application according to claim 1, which is characterized in that the Chinese medicine composition is by the original of following weight ratio
Material medicine is made：10 parts of Rhizoma Chuanxiong, 2.5 parts of Rhizoma Gastrodiae.
4. application according to claim 1, which is characterized in that the Chinese medicine composition is by the original of following weight ratio
Material medicine is made：9 parts of Rhizoma Chuanxiong, 5 parts of Rhizoma Gastrodiae.
5. according to the application described in claim 1-4, which is characterized in that the preparation formulation of the Chinese medicine composition be capsule,
Tablet, granule, powder, oral solution or pill.
6. application according to claim 5, which is characterized in that the preparation method of the Chinese medicine composition includes：
(1) Rhizoma Chuanxiong 5-25 is pressed, Rhizoma Gastrodiae 1.5-8 weight ratio takes two kinds of Rhizoma Chuanxiong, Rhizoma Gastrodiae components, is dried, crushes, mixing mixed
Close object；
(2) it uses 70%-90% alcohol refluxs to extract the mixture and obtains extracting solution and the dregs of a decoction 2-3 time, it is 1-3 hours each；
(3) merge the extracting solution, filter to get filtrate；
(4) filtrate is concentrated into the clear cream that 55-65 DEG C of relative density is 1.21-1.30.
7. application according to claim 6, which is characterized in that the preparation method of the Chinese medicine composition further includes：
(5) dregs of a decoction are decocted 1-2 hours with water, collecting decoction, filtering, and the filtrate after the decocting liquid is concentrated into 55-65 DEG C of phase
To the clear cream that density is 1.21-1.30, preferably decoct 1 hour；
(6) merge clear cream obtained by step (4) and step (5).
8. the application described according to claim 6 or 7, which is characterized in that the weight ratio of Rhizoma Chuanxiong and Rhizoma Gastrodiae is 10- in step (1)
25：1.5-8.
9. the application described according to claim 6 or 7, which is characterized in that step (2) is using described in the extraction of 90% alcohol reflux
Mixture 2 times extracting solution, 2 hours every time.
10. the application described according to claim 6 or 7, which is characterized in that the phase of clear cream obtained by step (4) and/or step (5)
It is 1.27 to density.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028883A (en) * | 2009-09-28 | 2011-04-27 | 江苏康缘药业股份有限公司 | Standard fingerprint spectrum of Chinese medicinal composition, and measurement method and application thereof |
| CN106266632A (en) * | 2016-08-25 | 2017-01-04 | 江苏康缘药业股份有限公司 | The purposes of Chinese medicine composition |
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2018
- 2018-06-28 CN CN201810686303.1A patent/CN108653586A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028883A (en) * | 2009-09-28 | 2011-04-27 | 江苏康缘药业股份有限公司 | Standard fingerprint spectrum of Chinese medicinal composition, and measurement method and application thereof |
| CN106266632A (en) * | 2016-08-25 | 2017-01-04 | 江苏康缘药业股份有限公司 | The purposes of Chinese medicine composition |
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