CN108653077A - A kind of draft Whelk-eliminating paste and preparation method thereof - Google Patents
A kind of draft Whelk-eliminating paste and preparation method thereof Download PDFInfo
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- CN108653077A CN108653077A CN201810571312.6A CN201810571312A CN108653077A CN 108653077 A CN108653077 A CN 108653077A CN 201810571312 A CN201810571312 A CN 201810571312A CN 108653077 A CN108653077 A CN 108653077A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of draft Whelk-eliminating pastes and preparation method thereof.The draft Whelk-eliminating paste is made of each raw material of following parts by weight：60 80 parts of 35 parts of Radix Adenophorae extract, 0.5 1 parts of perilla leaf extract, 0.5 1 parts of Caulis Lonicerae extract, 24 parts of radix paeoniae alba extraction, 0.5 1 parts of Leonurus extract, 0.5 1 parts of Angelica Dahurica extract, 25 parts of Flos Caryophylli extract, 35 parts of cetostearyl alcohol, 13 parts of glycerin monostearate, 6 10 parts of white oil, 13 parts of polymethyl siloxane, 15 parts of azone, 25 parts of glycerine, 0.4 0.6 parts of triethanolamine, 46 parts of glycerine and water.Experiments have shown that, the draft Whelk-eliminating paste of the present invention has the ability for significantly inhibiting propionibacterium acnes and staphylococcus epidermis breeding, also have the function of inhibiting tyrosinase activity simultaneously, human trial proves, using the draft Whelk-eliminating paste of the present invention, there is significant curative effect for Whiteheads, blackhead, papule, tumour tubercle and useless fellow.A kind of draft Whelk-eliminating paste of the present invention will have broad application prospects.
Description
Technical field
The present invention relates to a kind of draft Whelk-eliminating pastes and preparation method thereof, and the invention belongs to cosmetic technical fields.
Background technology
Whelk, also known as acne are a kind of chronic inflammatory skins of pilosebaceous unit, are mainly apt to occur in blueness
Teenager, it is very big to teen-age psychology and social influence, but tend to nature after puberty and mitigate or fully recover.Clinical manifestation is with good
It sends out with the characteristics of the pleomorphism skin lesions such as acne, papule, warts, the tubercle of face.
The generation of whelk mainly blocks with hypersteatosis, pilosebaceous duct, bacterium infection and inflammatory reaction
Etc. factors it is closely related.Adolesce androgen especially testosterone in descendant's body level it is rapid increase, promote sebaceous glands hair
It educates and generates a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, dyssebacia to form angle simultaneously
Matter bolt, that is, micro mist thorn.Normal parasitic many microorganisms in hebetic pilosebaceous follicle, mainly propionibacterium acnes, secondly
For Malassezia furfur, staphylococcus epidermis etc..Due to pilosebaceous duct epithelium angling, the follicular orifice obstruction that becomes smaller is made to cause
Sebum secretion is obstructed, it is unsmooth to be discharged, siltation and generate " acne ".In the environment of this relatively hypoxia, above-mentioned bacterium is largely numerous
It grows and increases.
Propionibacterium acnes (Propionibacterium acnes), also referred to as Propiobacterium, Propionibacterium, are to make
At the main bacteria of whelk.Genome research shows that several genes of the bacterium can manufacture the enzyme that some decompose skin histology
With the protein of immunogenicity.Propionibacterium acnes can both hydrolyze the triglycerides in sebum, generate free fatty, and can
Generate some low molecular polypeptides；Free fatty can stimulate and damage hair follicle.Free fatty and these low molecules are more simultaneously
Peptide can generate the further damage that hydrolase aggravates hair follicle again with the inflammatory cells such as chemotactic neutrophil leucocyte, inflammatory cell；Most
Cause the leakage of follicular wall, rupture, disintegration, hair follicle content to enter dermal tissue around afterwards, adds certain bacterium infections, in
It is that there have been a series of clinical manifestations such as inflamed papules, warts, tubercle, tumour, abscess.
Related amynologic mechanism is the study found that the serum IgG antibody during patient body fluid is immune increases, and with the state of an illness
It aggravates and increases.Also propionibacterium acnes generate antibody in patient's body, and circulating antibody reaches part and takes part in Earlier period of inflammation
Pathogenic course.This bacterium can release neutrophilic chemotactic factor by classical and alternative pathway activating complement simultaneously,
Stimulate and aggravated the inflammatory reaction of acne.
Western medical treatment acne mainly uses antibiotic, tretinoin medicine and hormone medicine etc., but existing for these drugs
Adverse reaction and side effect etc. all become everybody very concern, also limit a large amount of uses of such drug.Therefore, it develops
A safe and effective product for resolving poxes is developed, meeting the vast active demand to consumer becomes the task of top priority.
Invention content
The purpose of the present invention is to provide one kind containing plurality of Chinese extract component, is capable of the cream of effective pox-eliminating whitening
And preparation method thereof.
In order to achieve the above object, present invention employs following technological means：
The mechanism that the present invention is generated according to acne exists on the basis of traditional Chinese medicine research experience for many years in conjunction with a large amount of experiment
The Chinese medicine that selection inhibition acne correlation pathogen largely quickly breeds simultaneously, selects with anti-inflammatory and reduces the medicine of immune response
Object, to achieve the effect that efficient anti-acne.In addition, on the basis of anti-acne, being added has promotion skin whitening and reparation skin
The Chinese medicine of damage reaches reparation skin whitening effect.
Specifically, a kind of draft Whelk-eliminating paste of the present invention, is made of each raw material of following parts by weight：Radix Adenophorae extract
3-5 parts, 0.5-1 parts of perilla leaf extract, 0.5-1 parts of Caulis Lonicerae extract, 2-4 parts of radix paeoniae alba extraction, Leonurus extract 0.5-1
Part, 0.5-1 parts of Angelica Dahurica extract, 2-5 parts of Flos Caryophylli extract, 3-5 parts of cetostearyl alcohol, 1-3 parts of glycerin monostearate, white oil
6-10 parts, 1-3 parts of polymethyl siloxane, 1-5 parts of azone, 2-5 parts of glycerine, 0.4-0.6 parts of triethanolamine, 4-6 parts of glycerine with
And 60-80 parts of water.
Wherein, adenophora tetraphylla is four leaf the root of straight ladybell Adenophora tetraphylla (Thunb.) of Campanulaceae the root of straight ladybell platymiscium
Fisch.A.berticillata (Pall.) Fisch., apricot leaf the root of straight ladybell A.axilliflora Borb A.stricta Miq. or
Its congener, is used as medicine with root.Research finds that Cellular Immunity and nospecific immunity can be improved in the root of straight ladybell, and body fluid is inhibited to exempt from
Epidemic disease.Have the function of adjusting immunologic balance.Lymphocyte proliferation test also can be improved in the root of straight ladybell.To microsporum audouini, wool
The dermatophytes such as sample microsporum have different degrees of inhibiting effect.
Perilla leaf is also perilla leaf (Folium Perillae),《Drugization justice》Perilla leaf, for the object of generation.Pungent-warm energy
It dissipates, gas Bao Nengtong, taste is thin to be given vent to, and special expelling pathogenic factors from muscles and skin is delivered, and wind typhoid fever of curing the wound and malaria are from the beginning of, diseases caused by external factors cholera, hygropyretic beriberi, all categories
Table disease puts the key medicine of perverse trend outlet.
Caulis lonicerae is the drying stem branch of caprifoliaceae plant honeysuckle Lonicera japonica Thunb..Autumn, two season of winter adopt
It cuts, dries.It is mainly used for clearing heat and detoxicating, dispelling wind dredging collateral.For warm disease heating, toxic-heat and blood stasis, carbuncle swells sore, beriberoid pyretic arthralgia, pass
Save red and swollen heat pain.
Radix Paeoniae Alba, the entitled Cynanchum otophyllum of Latin, are Ranunculaceae Radix Paeoniae Alba platymisciums, are cohosh Chinese herbaceous peonies
Dry root.Summer, the excavation of two season of autumn, clean, remove end to end and radicula, set and are boiled again after removing crust or peeling after being boiled in boiling water,
It dries.It is mainly used for smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, abdominal pain, four limbs contraction pain, the deficiency of blood
It is sallow, irregular menstruation, spontaneous perspiration, night sweat.
Motherwort, also known as：Tui, motherwort, female grass, nine Paris polyphylla, mica grass, the gloomy base of a fruit, Classification system：Leonurus
Artemisia (Laur.) S.Y.Hu F are Labiatae, mother wort plant, summer-flowering.Its dry aerial parts is common
Chinese medicine, acrid flavour is bitter, cool, invigorates blood circulation, silt of dispelling, menstruation regulating, disappear water, treatment menoxenia, threatened abortion difficult labour, placenta retension, postpartum blood
Dizzy, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria rushes down blood, carbuncle swells sore.
The root of Dahurain angelica, scientific name：Angelica dahurica are the plant of Umbelliferae angelica.Meridian distribution of property and flavor：It is acrid in flavour and warm in nature.Return lung,
Stomach.With expelling wind and clearing away cold, sensible analgesic, detumescence and apocenosis, eliminating dampness stops band and other effects.For having a headache, having a toothache, nasosinusitis, intestines wind hemorrhoid
Leakage, leukorrhea with reddish discharge, ulcer sores, pruitus.
Cloves, this product are the dry flower of plant clove of myrtaceae Eugenia caryophllata Thunb..Work as flower
Flower bud is picked when turning red by green, is dried.Bud (flos caryophylli) contains volatile oil (i.e. caryophyllus oil) 14~20%, contains eugenol in oil
(eugenol) 78~95%, aceteugenol (acetyl eugenol) about 3% and a small amount of cloves alkene
(caryophyllene), the positive heptanone of Methylpentanone, methyl, vanillin；In addition, still containing oleanolic acid, tannin, fat oil
And it is cured.Fruit (Fructus Caryophylli) contains volatile oil 2~9%.For deficiency-cold in spleen and stomach, hiccup vomiting, deficiency of food is vomited and diarrhoea, trusted subordinate's crymodynia, kidney deficiency
Impotence.
Wherein, it is preferred that the draft Whelk-eliminating paste is made of each raw material of following parts by weight：4 parts of Radix Adenophorae extract,
1 part of perilla leaf extract, 0.7 part of Caulis Lonicerae extract, 3 parts of radix paeoniae alba extraction, 1 part of Leonurus extract, Angelica Dahurica extract 0.8
Part, 3.5 parts of Flos Caryophylli extract, 4 parts of cetostearyl alcohol, 2 parts of glycerin monostearate, 8 parts of white oil, 2 parts of polymethyl siloxane, nitrogen
65 parts of 3 parts of ketone, 3 parts of glycerine, 0.5 part of triethanolamine, 5 parts of glycerine and water.
Wherein, it is preferred that the extract is prepared in accordance with the following methods respectively：
(1) preparation of perilla leaf extract, Angelica Dahurica extract and radix paeoniae alba extraction：Perilla leaf, the root of Dahurain angelica, Radix Paeoniae Alba are washed respectively
Only after, dry, crushing, and 20 mesh sieve is crossed；By the powder percent by volume after sieving be 60%~95% ethyl alcohol 75~
Carry out refluxing extraction at 85 DEG C, bulk pharmaceutical chemicals and ethyl alcohol mass volume ratio g/mL are 1~3: 10~50, refluxing extraction 3-5h, altogether into
Then row 3-4 times merges extract, be cooled to 20 DEG C~30 DEG C, and 50~100 mesh filter-cloth filterings obtain filtrate；To obtained filter
It is added in liquid and the 1,3-BDO of ethyl alcohol same volume accumulated amount is miscible uniformly, the ethyl alcohol in solution is concentrated under reduced pressure out, then vacuum
Decompression filters, and filtrate is freeze-dried through activated carbon decolorizing up to perilla leaf extract, Angelica Dahurica extract and radix paeoniae alba extraction；
(2) preparation of Flos Caryophylli extract：Cloves bud is weighed, round-bottomed flask is packed into, after soaking, directly heats progress
Steam distillation collects distillate, and it is that 1.2-1.25 carries to get cloves that distillate, which continues relative density at a temperature of being concentrated into 80 DEG C,
Take object；
(3) preparation of Radix Adenophorae extract, Caulis Lonicerae extract and Leonurus extract：By adenophora tetraphylla, caulis lonicerae with
And motherwort is cleaned, is dry respectively, after crushing, and cross 20 mesh sieve；Powder after sieving is added water to cook three times respectively, is added every time
8-12 times is measured water, is decocted 2-3 times, 1-3 hours each, collecting decoction, filtration, merging filtrate, and filtrate is through activated carbon decolorizing, freezing
It is drying to obtain Radix Adenophorae extract, Caulis Lonicerae extract and Leonurus extract.
Further, the invention also provides a kind of method preparing the draft Whelk-eliminating paste, include the following steps：
(1) each raw material is weighed according to parts by weight of the present invention；
(2) cetostearyl alcohol, glycerin monostearate, white oil, polymethyl siloxane and glycerine are placed in container,
It is heated to 80-85 DEG C, is uniformly mixed, obtains oil phase；
(3) by glycerine and water merging container, it is heated to 80-85 DEG C, homogeneous is uniformly mixed, and obtains water phase；
(4) oil phase is slowly added in water phase, addition azone, triethanolamine stir evenly after homogeneous 3-5min, finally add
Enter Radix Adenophorae extract, perilla leaf extract, Caulis Lonicerae extract, radix paeoniae alba extraction, Leonurus extract, Angelica Dahurica extract, fourth
Fragrant extract stirs evenly, and keeps the temperature 20 minutes, obtains cream.
Compared to the prior art, the beneficial effects of the invention are as follows：
A kind of draft Whelk-eliminating paste of the present invention is made of natural plant extracts and auxiliary material, without containing antibiotic and
Hormonal components, green, safety.In addition, it is demonstrated experimentally that the present invention draft Whelk-eliminating paste have significantly inhibit propionibacterium acnes with
And the ability of staphylococcus epidermis breeding, while also having the function of inhibiting tyrosinase activity, human trial proves, uses this
The draft Whelk-eliminating paste of invention has significant curative effect for Whiteheads, blackhead, papule, tumour tubercle and useless fellow.The present invention
Draft Whelk-eliminating paste will have broad application prospects.
Specific implementation mode
The following examples are further illustrations of the invention, it should not be understood as limitation of the present invention.
The preparation of 1 Chinese medical extract of embodiment
(1) preparation of perilla leaf extract, Angelica Dahurica extract and radix paeoniae alba extraction：Perilla leaf, the root of Dahurain angelica, Radix Paeoniae Alba are washed respectively
Only after, dry, crushing, and 20 mesh sieve is crossed；Powder after sieving is carried out with the ethyl alcohol that percent by volume is 75% at 80 DEG C
Refluxing extraction, bulk pharmaceutical chemicals are 1: 20, refluxing extraction 4h with ethyl alcohol mass volume ratio g/mL, carry out 3 times, then close extract altogether
And 20 DEG C are cooled to, 80 mesh filter-cloth filterings obtain filtrate；1, the 3- fourths with ethyl alcohol same volume accumulated amount are added into obtained filtrate
Glycol is miscible to be uniformly concentrated under reduced pressure out the ethyl alcohol in solution, and then vacuum decompression filters, and for filtrate through activated carbon decolorizing, freezing is dry
Dry perilla leaf extract, Angelica Dahurica extract, radix paeoniae alba extraction to obtain the final product；
(2) cloves bud is weighed, round-bottomed flask is packed into, after soaking, carry out steam distillation is directly heated, collects and steam
Distillate, it is 1.2-1.25 to get Flos Caryophylli extract that distillate, which continues relative density at a temperature of being concentrated into 80 DEG C,；
(2) preparation of Radix Adenophorae extract, Caulis Lonicerae extract and Leonurus extract：By adenophora tetraphylla, caulis lonicerae with
And motherwort is cleaned, is dry respectively, after crushing, and cross 20 mesh sieve；Powder after sieving is added water to cook three times respectively, is added every time
10 times of amount water decoct 3 times, and 2 hours every time, collecting decoction filtered, merging filtrate, and filtrate is through activated carbon decolorizing, freeze-drying
Obtain Radix Adenophorae extract, Caulis Lonicerae extract and Leonurus extract.
The preparation of 2 draft Whelk-eliminating paste of embodiment
(1) parts by weight as described below weigh each raw material：
4 parts of Radix Adenophorae extract, 1 part of perilla leaf extract, 0.7 part of Caulis Lonicerae extract, 3 parts of radix paeoniae alba extraction, motherwort
It is 1 part of extract, 0.8 part of Angelica Dahurica extract, 3.5 parts of Flos Caryophylli extract, 4 parts of cetostearyl alcohol, 2 parts of glycerin monostearate, white
65 parts of 8 parts of oil, 2 parts of polymethyl siloxane, 3 parts of azone, 3 parts of glycerine, 0.5 part of triethanolamine, 5 parts of glycerine and water；
(2) cetostearyl alcohol, glycerin monostearate, white oil, polymethyl siloxane and glycerine are placed in container,
It is heated to 80-85 DEG C, is uniformly mixed, obtains oil phase；
(3) by glycerine and water merging container, it is heated to 80-85 DEG C, homogeneous is uniformly mixed, and obtains water phase；
(4) oil phase is slowly added in water phase, addition azone, triethanolamine stir evenly after homogeneous 3-5min, finally add
Enter Radix Adenophorae extract, perilla leaf extract, Caulis Lonicerae extract, radix paeoniae alba extraction, Leonurus extract, Angelica Dahurica extract, fourth
Fragrant extract stirs evenly, and keeps the temperature 20 minutes, obtains cream.
The preparation of 3 draft Whelk-eliminating paste of embodiment
(1) parts by weight as described below weigh each raw material：
3 parts of Radix Adenophorae extract, 1 part of perilla leaf extract, 0.5 part of Caulis Lonicerae extract, 4 parts of radix paeoniae alba extraction, motherwort
0.5 part of extract, 1 part of Angelica Dahurica extract, 5 parts of Flos Caryophylli extract, 3 parts of cetostearyl alcohol, 3 parts of glycerin monostearate, white oil 6
Part, 3 parts of polymethyl siloxane, 2 parts of azone, 2 parts of glycerine, 0.6 part of triethanolamine, 4 parts of glycerine and 70 parts of water；
(2) cetostearyl alcohol, glycerin monostearate, white oil, polymethyl siloxane and glycerine are placed in container,
It is heated to 80-85 DEG C, is uniformly mixed, obtains oil phase；
(3) by glycerine and water merging container, it is heated to 80-85 DEG C, homogeneous is uniformly mixed, and obtains water phase；
(4) oil phase is slowly added in water phase, addition azone, triethanolamine stir evenly after homogeneous 3-5min, finally add
Enter Radix Adenophorae extract, perilla leaf extract, Caulis Lonicerae extract, radix paeoniae alba extraction, Leonurus extract, Angelica Dahurica extract, fourth
Fragrant extract stirs evenly, and keeps the temperature 20 minutes, obtains cream.
The preparation of 4 draft Whelk-eliminating paste of embodiment
(1) parts by weight as described below weigh each raw material：
5 parts of Radix Adenophorae extract, 0.5 part of perilla leaf extract, 1 part of Caulis Lonicerae extract, 2 parts of radix paeoniae alba extraction, motherwort
It is 0.5 part of extract, 0.5 part of Angelica Dahurica extract, 2 parts of Flos Caryophylli extract, 5 parts of cetostearyl alcohol, 1 part of glycerin monostearate, white
60 parts of 10 parts of oil, 1 part of polymethyl siloxane, 5 parts of azone, 5 parts of glycerine, 0.6 part of triethanolamine, 6 parts of glycerine and water；
(2) cetostearyl alcohol, glycerin monostearate, white oil, polymethyl siloxane and glycerine are placed in container,
It is heated to 80-85 DEG C, is uniformly mixed, obtains oil phase；
(3) by glycerine and water merging container, it is heated to 80-85 DEG C, homogeneous is uniformly mixed, and obtains water phase；
(4) oil phase is slowly added in water phase, addition azone, triethanolamine stir evenly after homogeneous 3-5min, finally add
Enter Radix Adenophorae extract, perilla leaf extract, Caulis Lonicerae extract, radix paeoniae alba extraction, Leonurus extract, Angelica Dahurica extract, fourth
Fragrant extract stirs evenly, and keeps the temperature 20 minutes, obtains cream.
The inhibition of Chinese medical extract part in 1 product of the present invention of experimental example
1, tested strain
Propionibacterium acnes freeze-drying lactobacillus ATCC 11827, staphylococcus aureus ATCC6538.
2, for trying culture medium
10% sheep blood and 2% agar is added in improvement GAM broth bouillons, dissolves by heating, 115 DEG C of high pressure sterilization 15min,
It is poured in tablet culture dish, the recovery tablet and slant medium of freeze-dried vaccine is used as with this.
3, the preparation of bacteria suspension
It is seeded in tablet using plate streak by bacterial strain is lyophilized, after 37 DEG C of Anaerobic culturel 72h, what picking was individually grown
Bacterium colony is seeded to improvement GAM broth bouillons, continues culture for 24 hours, as bacteria suspension.
4, subject material：
Experimental group I：Radix Adenophorae extract
Experimental group II：Perilla leaf extract
Experimental group III：Caulis Lonicerae extract
Experimental group IV：Radix paeoniae alba extraction
Experimental group V：Leonurus extract
Experimental group VI：Angelica Dahurica extract
Experimental group VII：Flos Caryophylli extract
Experimental group VIII：Chinese medical extract mixture (Radix Adenophorae extract: perilla leaf extract: Caulis Lonicerae extract: Radix Paeoniae Alba
Extract: Leonurus extract: Angelica Dahurica extract: Flos Caryophylli extract=4: 1: 0.7: 3: 1: 0.8: 2)
Chinese medical extract is prepared according to 1 method of embodiment.The above extract of identical weight is taken, it is molten that distilled water progress is added
Solution, the solution for being configured to 25mg/ml are used for following experiment.
5, bacteriostatic experiment specific steps：
Using disc diffusion method, is carried out under aseptic condition, filter paper is broken into the circular filter paper of diameter 6mm with card punch
Piece, is placed in clean clean small beaker, after 115 DEG C of hot air sterilization 20min, is respectively put into the sample for the experimental group I-VIII that sterilized
It is fully impregnated in liquid, 8 filter papers is put into each sample liquid.Melt prepared for examination culture medium, pours into training respectively
It supports in ware, 115 DEG C of sterilizing 20min, after solidification to be cooled, it is uniform in being coated on tablet to draw 0.1ml bacteria suspensions.Use aseptic nipper
The a diameter of 6mm circular filter paper pieces impregnated in putting forward sample liquid are gripped respectively, are attached on tablet containing bacterium, in each tablet etc.
Each culture dish is placed in 37 DEG C of constant incubator middle plateforms and is inverted culture for 24 hours, measures the size of antibacterial circle diameter by distance patch 4,
If 3 repetitions, take its average value.The results are shown in Table 3.
The fungistatic effect of the different sample liquids of table 1 compares
As it can be seen from table 1 in the case of same dosage, compared to single component, the mixture of Chinese medical extract has
There is the activity of higher inhibition propionibacterium acnes and staphylococcus aureus.
Chinese medical extract part inhibits tyrosinase activity evaluation in 2 product of the present invention of experimental example
1, material：Tyrosinase, l-tyrosine, disodium hydrogen phosphate, sodium dihydrogen phosphate thermostat, ultraviolet specrophotometer,
Centrifuge.
Material to be tested：Chinese medical extract mixture (Radix Adenophorae extract: perilla leaf extract: Caulis Lonicerae extract: Radix Paeoniae Alba carries
Take object: Leonurus extract: Angelica Dahurica extract: Flos Caryophylli extract=4: 1: 0.7: 3: 1: 0.8: 2)
Chinese medical extract is prepared according to 1 method of embodiment.The above extract of identical weight is taken, it is molten that distilled water progress is added
Solution, the solution for being configured to 25mg/ml are used for following experiment.
2 preparation of reagents：
1) sodium phosphate buffer (1/15mol/L, pH=6.8)：Accurately weigh 1.000g sodium dihydrogen phosphates, 1.186g phosphoric acid
Disodium hydrogen after a small amount of deionized water dissolving is added, is settled to 500mL, and 4 DEG C of refrigerators save backup.
2) l-tyrosine solution (7.5mmol/L)：L-tyrosine 0.272g accurately is weighed, few drops of concentrated hydrochloric acids are first added, add
Deionized water about 50mL after low-grade fever is completely dissolved, with sodium hydroxide solution tune pH to 7 or so, adds deionized water to be settled to
200mL。
3, detection method
Overall reaction system is 5mL.When experiment, sequentially added into test tube sodium phosphate buffer, different volumes by test solution,
Enzyme solution, in 30 DEG C of water-bath 10min.Then substrate l-tyrosine is added, immediately begins to timing.475nm waves when measuring reaction 20min
Light absorption value under long.When measurement, using corresponding negative control as reference, Chinese medical extract mixture is calculated to junket with following equation
The inhibiting rate of propylhomoserin enzyme, and according to the approximation of concentration-enzyme inhibition rate curve estimation half-inhibition concentration (IC50).
Inhibiting rate=[(A-B)/A] × 100%
Wherein, " A " is the light absorption value of standard control, and " B " is the light absorption value by test solution.Experiment do 3 it is parallel.Inhibiting rate is high
Show that it is high to the inhibition strength of tyrosinase activity.
4, result
Chinese medical extract mixture is shown in Table 2 to tyrosinase In-vitro Inhibitory Effect, as shown in Table 2, Chinese medical extract mixing
Object all has tyrosinase certain inhibiting effect.
2 tyrosinase inhibition rate of table
| The amount (ml) of addition | Tyrosinase inhibition rate (%) |
| 0.5 | 25 |
| 1.0 | 30 |
| 1.5 | 42 |
3 normal individual trial of experimental example is tested
1, experimental subjects and grouping
Light, moderate face acne vulgaris volunteer totally 50 is chosen, man, female are fifty-fifty；It is age 16-32 Sui, 22 years old average.
2 weeks before smearing cosmetics, glucocorticosteroid hormone, tretinoin and antibiotics, no hyperlipidemia and hepatic and renal function was not used
It is abnormal, forbid indulging in excessive drinking, avoids sunburst or ultraviolet light excessive radiation.Volunteer is randomly divided into two groups, every group of 25 people：
First group：Morning and evening warm water cleaning skin and after drying, takes the draft Whelk-eliminating paste that appropriate embodiment 2 is prepared uniform
It is applied to face；
Second group：Morning and evening warm water cleaning skin and after drying, take in right amount without Chinese medical extract ingredient cosmetic base (i.e.
According to the method for embodiment 2, but it is added without Chinese medical extract) uniformly it is applied to face.
2, observation statistics
Other drugs or cosmetics are deactivated during use.Continuous on probation 28 days, and require the 14th day (D14) and the of experiment
(D28) is paid a return visit within 28 days.Evaluation content include the Whiteheads of volunteer's left and right face, blackhead, papule, tumour tubercle with
And the acne of 5 ranks of warts carries out the label and number statistical of number, while skin brightness to volunteer and acne
Healing state is observed.As a result as shown in table 3 below：
3 statistical result of table
Table 3 is the results show that first group and second group of statistical result there are notable difference, illustrates that the Chinese medicine wherein contained carries
Object is taken to have the inhibition of highly significant to acne.Under dosage same case, compared to the cream energy without Chinese medical extract
Enough significantly improve the effect for inhibiting acne.
The healing state of skin brightness and acne to volunteer is observed, and is found compared to second group, first group
The colour of skin of volunteer obviously bleaches, and becomes more flexible, and the skin surface flatness of volunteer obviously makes moderate progress, red complexion
Moisten and glossy, greatly reduce scar and pigmentation, skin is made to restore normal fine and smooth soft and smooth.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (4)
1. a kind of draft Whelk-eliminating paste, which is characterized in that be made of each raw material of following parts by weight：3-5 parts of Radix Adenophorae extract, Soviet Union
0.5-1 parts of leaf extract, 0.5-1 parts of Caulis Lonicerae extract, 2-4 parts of radix paeoniae alba extraction, 0.5-1 parts of Leonurus extract, the root of Dahurain angelica
0.5-1 parts of extract, 2-5 parts of Flos Caryophylli extract, 3-5 parts of cetostearyl alcohol, 1-3 parts of glycerin monostearate, 6-10 parts of white oil,
1-3 parts of polymethyl siloxane, 1-5 parts of azone, 2-5 parts of glycerine, 0.4-0.6 parts of triethanolamine, 4-6 parts of glycerine and water 60-
80 parts.
2. draft Whelk-eliminating paste as described in claim 1, which is characterized in that be made of each raw material of following parts by weight：Adenophora tetraphylla
4 parts of extract, 1 part of perilla leaf extract, 0.7 part of Caulis Lonicerae extract, 3 parts of radix paeoniae alba extraction, 1 part of Leonurus extract, the root of Dahurain angelica
0.8 part of extract, 3.5 parts of Flos Caryophylli extract, 4 parts of cetostearyl alcohol, 2 parts of glycerin monostearate, 8 parts of white oil, poly- methyl silicon
65 parts of 2 parts of oxygen alkane, 3 parts of azone, 3 parts of glycerine, 0.5 part of triethanolamine, 5 parts of glycerine and water.
3. draft Whelk-eliminating paste as claimed in claim 1 or 2, which is characterized in that the extract difference is in accordance with the following methods
It is prepared：
(1) preparation of perilla leaf extract, Angelica Dahurica extract and radix paeoniae alba extraction：Perilla leaf, the root of Dahurain angelica, Radix Paeoniae Alba are cleaned respectively, is dry
After dry, crushing, and cross 20 mesh sieve；By the powder percent by volume after sieving be 60%~95% ethyl alcohol at 75~85 DEG C
Refluxing extraction is carried out, bulk pharmaceutical chemicals are 1~3: 10~50 with ethyl alcohol mass volume ratio g/mL, and refluxing extraction 3-5h carries out 3-4 altogether
It is secondary, then extract is merged, is cooled to 20 DEG C~30 DEG C, 50~100 mesh filter-cloth filterings obtain filtrate；Into obtained filtrate
It is added and the 1,3-BDO of ethyl alcohol same volume accumulated amount is miscible uniformly, the ethyl alcohol in solution is concentrated under reduced pressure out, then vacuum decompression
It filters, filtrate is freeze-dried through activated carbon decolorizing up to perilla leaf extract, Angelica Dahurica extract and radix paeoniae alba extraction；
(2) preparation of Flos Caryophylli extract：Cloves bud is weighed, round-bottomed flask is packed into, after soaking, directly heats and carries out water steaming
Distillate is collected in steam distillation, and it is that 1.2-1.25 extracts to get cloves that distillate, which continues relative density at a temperature of being concentrated into 80 DEG C,
Object；
(3) preparation of Radix Adenophorae extract, Caulis Lonicerae extract and Leonurus extract：By adenophora tetraphylla, caulis lonicerae and benefit
Brittle Falsepimpernel Herb is cleaned, is dry, respectively after crushing, and crosses 20 mesh sieve；Powder after sieving is added water to cook three times respectively, adds 8-12 every time
Amount water again decocts 2-3 times, 1-3 hours each, collecting decoction, filtration, merging filtrate, and filtrate is through activated carbon decolorizing, freeze-drying
Up to Radix Adenophorae extract, Caulis Lonicerae extract and Leonurus extract.
4. a kind of method preparing claim 1-3 any one of them draft Whelk-eliminating pastes, which is characterized in that including following step
Suddenly：
(1) each raw material is weighed according to parts by weight as claimed in claim 1 or 2；
(2) cetostearyl alcohol, glycerin monostearate, white oil, polymethyl siloxane and glycerine are placed in container, heating
To 80-85 DEG C, it is uniformly mixed, obtains oil phase；
(3) by glycerine and water merging container, it is heated to 80-85 DEG C, homogeneous is uniformly mixed, and obtains water phase；
(4) oil phase is slowly added in water phase, addition azone, triethanolamine stir evenly after homogeneous 3-5min, are eventually adding south
Radix Adenophorae (Radix Glehniae) extract, perilla leaf extract, Caulis Lonicerae extract, radix paeoniae alba extraction, Leonurus extract, Angelica Dahurica extract, cloves carry
It takes object to stir evenly, keeps the temperature 20 minutes, obtain draft Whelk-eliminating paste.
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| CN114831908A (en) * | 2022-04-28 | 2022-08-02 | 江苏农牧科技职业学院 | Ginkgo episperm anti-aging acne-removing cream and preparation method thereof |
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