CN108652991B - A kind of preparation method of the composition with smooth skin effect - Google Patents
A kind of preparation method of the composition with smooth skin effect Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to a kind of preparation methods of composition with smooth skin effect, it is characterized in that using following steps: A, 1:1-5:3-6:1:1-3 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, dimethyl sulfone, form the composition of smooth skin effect, it is mixed with polyalcohol, obtains efficacy solution；B, dimethyl silicone polymer, octyl dodecanol, saualane Hybrid Heating are obtained into oily phase in mass ratio；C, hydrolecithin and Natrulon H-10 stearate are mixed in mass ratio, obtains blended emulsifier；D, blended emulsifier and deionized water are mixed into obtain water phase；E, Phenoxyethanol and Sensiva SC50 are mixed into obtain antiseptic solution；F, above-mentioned oily phase, water phase, efficacy solution and antiseptic solution are mixed in mass ratio, passes through high-pressure homogeneous the composition with smooth skin effect.The present invention has the advantages that being capable of smooth skin.
Description
Technical field
The invention belongs to cosmetic technical field, in particular to the preparation side of a kind of composition with smooth skin effect
Method.
Background technique
With advancing age, it is interior because and the collective effect of external cause under, there is wrinkle, relaxation etc. in skin gradually aging
Sign, and the performance of these agings not only influences self-image, but also influences personal physical and mental health, therefore has smooth skin function
The product of effect has the huge market demand and development space.
For skin aging, wrinkle Producing reason, i.e., moisture is reduced in skin, and collagen fabric attenuates, elastic egg
White elasticity reduces, and collagen interacts the well-regulated network structure of composition with elastin laminin and is gradually disintegrated in original corium, causes
Skin wrinkle generates, and solves the problems, such as above-mentioned skin in the prior art, generallys use following approach and realizes: first is that increasing moisture of skin
Content repairs skin barrier；Second is that removing excessive active oxygen radical, enhance skin oxidation resistance；Third is that promoting cell
Metabolism and multiplication rate；Fourth is that promoting the generation of the collagen and elastin laminin in skin.Pass through above-mentioned four kinds of approach
Can smooth skin, but with smooth skin effect effective component, especially removing free radical, it is oxidation resistant activity at
Point, there is stability problem mostly, easily occur losing activity during use and storage and the phenomenon that color change, while portion
Point active constituent the problems such as there are smell, color, solubility, limit the exploitation and use of product.
Summary of the invention
The technical problem to be solved by the present invention is to, a kind of preparation method of composition with smooth skin effect is provided,
The composition have stability it is good, it is easy to use, can comprehensive smooth skin the advantages of, overcome smooth muscle in the prior art
The problems such as skin product mechanism of action is single, product stability is poor, inconvenient for use, effect is not significant.
In order to solve the above technical problems, the invention adopts the following technical scheme: a kind of combination with smooth skin effect
The preparation method of object, it is characterised in that use following steps:
A, 1:1-5:3-6:1:1-3 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, two
Methyl sulfone forms the composition of smooth skin effect；It heats, stir after the composition is mixed with polyalcohol 1:5-15 in mass ratio
It mixes to being completely dissolved, is cooled to room temperature to obtain efficacy solution；
B, 3-6:2:1 in mass ratio weighs dimethyl silicone polymer, octyl dodecanol, saualane, heating stirring to 75-80
DEG C, obtain oily phase；
C, 1-2:1 in mass ratio weighs hydrolecithin and Natrulon H-10 stearate, obtains blended emulsifier；
D, 1:10-30 in mass ratio weighs blended emulsifier obtained by step C and deionized water, stirs evenly, is heated to 75-
85 DEG C, obtain water phase；
E, 1-5:1 weighs Phenoxyethanol and Sensiva SC50 in mass ratio, is uniformly mixed, and obtains antiseptic solution；
F, by above-mentioned oily phase, water phase, efficacy solution and antiseptic solution 10:10-30:10-20:1 in mass ratio
It is mixed, is heated to 75-85 DEG C, stirred evenly, it is equal by high pressure then under the conditions of 80-120MPa, 75-80 DEG C of temperature
Matter machine recycles homogeneous 5-10 times, obtains the composition with smooth skin effect.
Composition prepared by the present invention with smooth skin effect is nano liposomes, and the particle size range of liposome exists
100-150nm。
The extracts of red clover (TRIFOLIUM PRATENSE (CLOVER) EXTRACT) " has used in China
Cosmetic material Names Catalogue (2015 editions) " in serial number 02856, be purchased from Dao Sifu Biotechnology Co., Ltd, purity is not
Less than 98%.Extracts of red clover is containing the ingredients such as flavonoids, protein, amino acid, carbohydrate and vitamin, main active
It is isoflavones.By removing, free radical, anti-lipid peroxidation, protection DNA are not oxidized to be destroyed, improves all kinds of enzymatic activitys and reach
To the effect of delaying senility, smooth skin.
The genistein (Genistein) also known as Genistein, No. CAS: 446-72-0 are purchased from Dao Sifu biology
Science and Technology Ltd., purity are not less than 98%.Genistein is the principle active component of isoflavones, has anti-oxidant, rush
It into skin collagen synthesis, stimulates epidermal cell proliferation, delay cuticula atrophy and epidermis thinning and other effects, to reach guarantor
The purpose held skin elasticity, reduce wrinkle, anti-aging.
The asiaticosid (ASIATICOSIDE), in Chinese " having used cosmetic material Names Catalogue (2015 editions) "
Serial number 03173, is purchased from Dao Sifu Biotechnology Co., Ltd, and purity is not less than 90%.Asiaticosid is by promoting into fiber
Cell growth, collagen synthesis and epithelial cell growth approach, reach improve skin elasticity, delaying skin aging mesh
's.
The ribose (RIBOSE), the serial number in Chinese " having used cosmetic material Names Catalogue (2015 editions) "
02786, it is purchased from Shanghai Yuan Ji Chemical Co., Ltd., purity is not less than 98%.Ribose is a kind of functional pentose, cell
The important component of core is the most basic energy of vital metabolic as the natural component being present in all cells in organism
One of source is measured, therefore ribose has effects that delay senescence.
The dimethyl sulfone (DIMETHYL SULFONE) also known as dimethyl sulfone, methyl sulfonamide methane and MSM, China "
Use cosmetic material Names Catalogue (2015 editions) " in serial number 02112, be purchased from Shanghai Yuan Ye Biotechnology Co., Ltd, it is pure
Degree is not less than 98%.Dimethyl sulfone is the very important organic sulfur source of life entity, have supplement skin moisture, eliminate free radical,
Skin immunological regulation, stimulated skin and other effects of releiving are improved, to restore elasticity of skin and gloss.
The polyalcohol is one of glycerol, butanediol, propylene glycol, dipropylene glycol, pentanediol, hexylene glycol, diglycerol
Or their mixture.
The dimethyl silicone polymer, English INCI title DIMETHICONE " have used cosmetic material name in China
Claim catalogue (2015 editions) " in serial number 03732, viscosity 20CST.
The octyl dodecanol, English INCI title OCTYLDODECANOL " have used cosmetic material title in China
Catalogue (2015 editions) " in serial number 07177.
The saualane English INCI title SQUALANE " has used cosmetic material Names Catalogue (2015 in China
Version) " in serial number 03432.
The hydrolecithin English INCI title HYDROGENATED LECITHIN " has used cosmetics former in China
Expect Names Catalogue (2015 editions) " in serial number 05378, there is German LIPOID company in commercial product.Currently preferred hydrogenation ovum
Phosphatide, the Phosphatidylcholine Hydrogenated quality contained are not less than 75% than content.
The Natrulon H-10 stearate English INCI title POLYGLYCERYL-10 STEARATE " has made in China
The material name catalogue that applies some make up (2015 editions) " in serial number 03798, there are NIKKOL CHEMICAL company, commodity in commercial product
Name NIKKOL DECAGLYN 1-SV.
The Phenoxyethanol English INCI title PHENOXYETHANOL " has used cosmetic material title mesh in China
Record (2015 editions) " in serial number 01294.
The Sensiva SC50 English INCI title ETHYLHEXYLGLYCERIN " has used cosmetics former in China
Expect Names Catalogue (2015 editions) " in serial number 07706.
To prove that beneficial effects of the present invention, further progress are tested as follows.
The following are the description of test of stability of the present invention: (composition is same for the smooth skin efficacy that mass concentration is 10%
Embodiment 1) glycerite, to be light yellow, room temperature is non-be protected from light under the conditions of place 4 weeks after, color becomes dark-brown；And it is identical
The smooth skin efficacy (composition is with embodiment 1) of quality, after liposome, under the conditions of same stored, after 4 weeks
Color is almost unchanged.It can keep stablizing after the centrifugation test of liposome 10000rpm, 30min not stratified；- 10 DEG C, 45 DEG C of environment
It is lower save three months it is not stratified, be basically unchanged color, do not have precipitation, have good stability.After overstability, average grain diameter is tested
It stills remain in the range of 100-150nm, illustrates the liposome of the composition prepared by the present invention with smooth skin effect
Stability is good.
The following are the explanations of smooth skin Efficacy experiments of the invention: choosing 90 ages on a voluntary basis at 35-50 years old
Between female volunteers, be divided into 9 groups of carry out parallel testings.Parallel testing sample 1-9 is all made of the preparation method system of embodiment 1
It is standby.It is required that subject uses daily, sooner or later respectively using primary, using preceding and using follow-up test is carried out after 1 month, amount to 2 times,
Follow-up is the same time in the daytime, and other same type products must not be used during test.During follow-up, user do not occur because
Skin allergy, phenomena such as generating erythema, itching using test sample.Subject needs in constant temperature and humidity (room temperature 22 before testing
DEG C ± 2 DEG C, relative humidity 45% ± 5%) under environment, sit quietly 20min and then using MPA580 skin elasticity tester and
PRIMOS PICO wrinkle of skin detector is to skin elasticity and wrinkle situation are measured and divide before using, after using 1 month
Analysis, is as a result shown in Tables 1 and 2 respectively.
Skin elasticity test data before and after 1 use of table
Wrinkle test data changing ratio (3D skin detecting method) before and after 2 use of table
Sample 1 is the nano liposomes of 5% a kind of active constituent of extracts of red clover containing mass fraction；
Sample 2 is the nano liposomes of 5% a kind of active constituent of genistein containing mass fraction；
Sample 3 is the nano liposomes of 5% a kind of active constituent of asiaticosid containing mass fraction；
Sample 4 is the nano liposomes of 5% a kind of active constituent of ribose containing mass fraction；
Sample 5 is the nano liposomes of 5% a kind of active constituent of dimethyl sulfone containing mass fraction；
Sample 6 is the nano-lipid containing 1.6% extracts of red clover of mass fraction, 3.4% 2 kinds of active constituents of genistein
Body；
Sample 7 is containing 0.8% extracts of red clover of mass fraction, 1.7% genistein, 2.5% asiaticosid, 3 kinds of activity
The nano liposomes of ingredient；
Sample 8 is containing 0.7% extracts of red clover of mass fraction, 1.4% genistein, 2.2% asiaticosid, 0.7% core
The nano liposomes of sugared 4 kinds of active constituents；
Sample 9 be containing 0.625% extracts of red clover of mass fraction, 1.25% genistein, 1.875% asiaticosid,
The nano liposomes of 0.625% ribose, 0.625% 5 kinds of active constituents of dimethyl sulfone；
Table 2 is skin elasticity data before and after 9 kinds of different sample uses, when R2 refers to no negative pressure the springback capacity of skin with have it is negative
The ratio between maximum tension amount when pressure, ratio illustrate that skin elasticity is better, R5 refers to the elasticity in skin recovery process closer to 1
Part illustrates that skin elasticity is better closer to 1 with the ratio between the elastic part for adding negative pressure process.From the data in the table, 9 kinds of samples
Product are increased using rear R2 and R5, and the effect that active ingredient combinations use in 5 is superior to individually or part is applied in combination, explanation
5 kinds of active constituents can effectively improve skin elasticity, and 5 kinds of active ingredient combinations, which use, has the function of synergy.
Table 2 is wrinkle of skin test data before and after 9 kinds of different sample uses, and wherein Sa, Sq, Sk, Sv, Wd are for characterizing wrinkle
The line depth, is defined as the wrinkle depth factor, and aWa, pWa are defined as wrinkle area factor, Wv is then for characterizing wrinkle area
It is the comprehensive parameters for characterizing wrinkle severity.From the data in the table, 9 kinds of samples use rear Sa, Sq, Sk, Wd, aWa, pWa
And the comprehensive parameters Wv of characterization wrinkle severity is reduced, the S with wrinkle severity negative correlationVIt improves, and living in 5
Property the effect that is applied in combination of ingredient be superior to individually or part is applied in combination, illustrate that 5 kinds of active constituents can effectively improve face
Wrinkle situation, for 5 kinds of active ingredient combinations using having the function of synergy, improvement is more significant.
The present invention is directed to the origin cause of formation of skin aging, by extracts of red clover, genistein, asiaticosid, ribose, diformazan
Liposome is made according to the merging of special ratios group in sulfone, compared with prior art, has the advantage that 5 kinds of activity in 1) composition
Ingredient is synergistic, achievees the effect that comprehensive smooth skin；2) by the active constituent liposome with smooth skin effect
Package, had not only improved the stability of active constituent, but also reduce its difficulty used, it is convenient to be added to each category product and match
The effect of Fang Zhong, nanometer particle size permeates it more preferably, plays smooth skin.
Specific embodiment
Technical solution of the present invention is described further by the following examples, but protection scope of the present invention and unlimited
In this.
Embodiment 1: a kind of preparation method of the composition with smooth skin effect, using following steps:
A, 1:3:4:1:3 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, dimethyl sulfone,
Form the composition of smooth skin effect；It heats, stirred to complete after the composition is mixed with polyalcohol 1:10 in mass ratio
Fully dissolved is cooled to room temperature to obtain efficacy solution；
B, 5:2:1 in mass ratio weighs dimethyl silicone polymer, octyl dodecanol, saualane, and heating stirring is obtained to 80 DEG C
Oily phase；
C, 1:1 in mass ratio weighs hydrolecithin and Natrulon H-10 stearate, obtains blended emulsifier；
D, 1:15 in mass ratio weighs blended emulsifier obtained by step C and deionized water, stirs evenly, is heated to 80 DEG C,
Obtain water phase；
E, 3:1 weighs Phenoxyethanol and Sensiva SC50 in mass ratio, is uniformly mixed, and obtains antiseptic solution；
F, above-mentioned oily phase, water phase, efficacy solution and antiseptic solution 10:20:20:1 in mass ratio are mixed
It closes, is heated to 80 DEG C, stirs evenly, then under the conditions of 100MPa, 80 DEG C of temperature, homogeneous 10 is recycled by high pressure homogenizer
It is secondary, the composition with smooth skin effect is obtained, resulting composition is nano liposomes, partial size 120nm.
Embodiment 2: a kind of preparation method of the composition with smooth skin effect, using following steps:
A, 1:2:5:1:1 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, dimethyl sulfone,
Form the composition of smooth skin effect；It heats, stirred to complete after the composition is mixed with polyalcohol 1:15 in mass ratio
Fully dissolved is cooled to room temperature to obtain efficacy solution；
B, 4:2:1 in mass ratio weighs dimethyl silicone polymer, octyl dodecanol, saualane, and heating stirring is obtained to 75 DEG C
Oily phase；
C, 1:1 in mass ratio weighs hydrolecithin and Natrulon H-10 stearate, obtains blended emulsifier；
D, 1:10 in mass ratio weighs blended emulsifier obtained by step C and deionized water, stirs evenly, is heated to 75 DEG C,
Obtain water phase；
E, 2:1 weighs Phenoxyethanol and Sensiva SC50 in mass ratio, is uniformly mixed, and it is molten to obtain preservative mixing
Liquid；
F, above-mentioned oily phase, water phase, efficacy solution and antiseptic solution 10:20:15:1 in mass ratio are mixed
It closes, is heated to 75 DEG C, stirs evenly, then under the conditions of 120MPa, 75 DEG C of temperature, homogeneous 10 is recycled by high pressure homogenizer
It is secondary, the composition with smooth skin effect is obtained, resulting composition is nano liposomes, partial size 105nm.
Embodiment 3: a kind of preparation method of the composition with smooth skin effect, using following steps:
A, 1:5:3:1:2 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, dimethyl sulfone,
Form the composition of smooth skin effect；It heats, stirred to complete after the composition is mixed with polyalcohol 1:10 in mass ratio
Fully dissolved is cooled to room temperature to obtain efficacy solution；
B, 3:2:1 in mass ratio weighs dimethyl silicone polymer, octyl dodecanol, saualane, and heating stirring is obtained to 80 DEG C
Oily phase；
C, 2:1 in mass ratio weighs hydrolecithin and Natrulon H-10 stearate, obtains blended emulsifier；
D, 1:18 in mass ratio weighs blended emulsifier obtained by step C and deionized water, stirs evenly, is heated to 80 DEG C,
Obtain water phase；
E, 2:1 weighs Phenoxyethanol and Sensiva SC50 in mass ratio, is uniformly mixed, and it is molten to obtain preservative mixing
Liquid；
F, above-mentioned oily phase, water phase, efficacy solution and antiseptic solution 10:30:20:1 in mass ratio are mixed
It closes, is heated to 80 DEG C, stirs evenly, then under the conditions of 90MPa, 80 DEG C of temperature, recycled homogeneous 8 times by high pressure homogenizer,
There must be the composition of smooth skin effect, resulting composition is nano liposomes, partial size 130nm.
Embodiment 4: a kind of preparation method of the composition with smooth skin effect, using following steps:
A, 1:2:3:1:2 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, dimethyl sulfone,
Form the composition of smooth skin effect；It heats, stirred to complete after the composition is mixed with polyalcohol 1:12 in mass ratio
Fully dissolved is cooled to room temperature to obtain efficacy solution；
B, 6:2:1 in mass ratio weighs dimethyl silicone polymer, octyl dodecanol, saualane, and heating stirring is obtained to 78 DEG C
Oily phase；
C, 1:1 in mass ratio weighs hydrolecithin and Natrulon H-10 stearate, obtains blended emulsifier；
D, 1:10 in mass ratio weighs blended emulsifier obtained by step C and deionized water, stirs evenly, is heated to 78 DEG C,
Obtain water phase；
E, 4:1 weighs Phenoxyethanol and Sensiva SC50 in mass ratio, is uniformly mixed, and it is molten to obtain preservative mixing
Liquid；
F, above-mentioned oily phase, water phase, efficacy solution and antiseptic solution 10:25:20:1 in mass ratio are mixed
It closes, is heated to 78 DEG C, stirs evenly, then under the conditions of 120MPa, 78 DEG C of temperature, recycled homogeneous 6 times by high pressure homogenizer,
There must be the composition of smooth skin effect, resulting composition is nano liposomes, partial size 135nm.
Embodiment 5: a kind of preparation method of the composition with smooth skin effect, using following steps:
A, 1:1:3:1:1 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, dimethyl sulfone,
Form the composition of smooth skin effect；It heats, stirred extremely after the composition is mixed with polyalcohol 1:5-15 in mass ratio
It is completely dissolved, is cooled to room temperature to obtain efficacy solution；
B, 6:2:1 in mass ratio weighs dimethyl silicone polymer, octyl dodecanol, saualane, and heating stirring is obtained to 80 DEG C
Oily phase；
C, 2:1 in mass ratio weighs hydrolecithin and Natrulon H-10 stearate, obtains blended emulsifier；
D, 1:16 in mass ratio weighs blended emulsifier obtained by step C and deionized water, stirs evenly, is heated to 80 DEG C,
Obtain water phase；
E, 3:1 weighs Phenoxyethanol and Sensiva SC50 in mass ratio, is uniformly mixed, and it is molten to obtain preservative mixing
Liquid；
F, above-mentioned oily phase, water phase, efficacy solution and antiseptic solution 10:25:15:1 in mass ratio are mixed
It closes, is heated to 80 DEG C, stirs evenly, then under the conditions of 110MPa, 80 DEG C of temperature, homogeneous 10 is recycled by high pressure homogenizer
It is secondary, the composition with smooth skin effect is obtained, resulting composition is nano liposomes, partial size 115nm.
The above description is only an embodiment of the present invention, is not intended to limit the scope of the invention, all to utilize this hair
The equivalent structure or equivalent flow shift that bright description is done is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (1)
1. a kind of preparation method of the composition with smooth skin effect, it is characterised in that use following steps:
A, 1:1-5:3-6:1:1-3 in mass ratio weighs extracts of red clover, genistein, asiaticosid, ribose, diformazan
Sulfone forms the composition of smooth skin effect；It heats, stir after the composition is mixed with polyalcohol 1:5-15 in mass ratio
To being completely dissolved, it is cooled to room temperature to obtain efficacy solution；
B, 3-6:2:1 in mass ratio weighs dimethyl silicone polymer, octyl dodecanol, saualane, heating stirring to 75-80 DEG C,
Obtain oily phase；
C, 1-2:1 in mass ratio weighs hydrolecithin and Natrulon H-10 stearate, obtains blended emulsifier；
D, 1:10-30 in mass ratio weighs blended emulsifier obtained by step C and deionized water, stirs evenly, is heated to 75-85
DEG C, obtain water phase；
E, 1-5:1 weighs Phenoxyethanol and Sensiva SC50 in mass ratio, is uniformly mixed, and obtains antiseptic solution；
F, above-mentioned oily phase, water phase, efficacy solution and antiseptic solution 10:10-30:10-20:1 in mass ratio are carried out
Mixing, is heated to 75-85 DEG C, stirs evenly, then under the conditions of 80-120MPa, 75-80 DEG C of temperature, pass through high pressure homogenizer
Circulation homogeneous 5-10 times, obtains the composition with smooth skin effect.
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| FR2945939B1 (en) * | 2009-05-26 | 2011-07-15 | Sederma Sa | COSMETIC USE OF TYR-ARG DIPEPTIDE TO FIGHT SKIN RELEASE. |
| FR2974296B1 (en) * | 2011-04-19 | 2013-05-24 | Inneov Lab | USE OF A COMBINATION OF A CAROTENOID, A PHYTOESTROGEN AND VITAMIN C AS AN AGENT FOR HYDRATION OF THE SKIN |
| CN102784084B (en) * | 2012-08-22 | 2014-11-26 | 珀莱雅化妆品股份有限公司 | Anti-aging lipid nanoparticle emulsion for skin and preparation method thereof |
| CN104586663B (en) * | 2013-10-31 | 2017-10-17 | 广州市纳爱生物科技有限公司 | A kind of body slimming frost |
| CN106619223B (en) * | 2016-12-28 | 2019-11-29 | 黑龙江中医药大学 | A kind of natural anti-aging cosmetics and preparation method thereof |
| CN107281005B (en) * | 2017-05-25 | 2020-03-27 | 珀莱雅化妆品股份有限公司 | Anti-wrinkle composition and preparation method of PIT nano emulsion thereof |
| CN107837204B (en) * | 2017-11-09 | 2020-12-11 | 苏州纳康生物科技有限公司 | Narrow-distribution-particle-size emulsion with skin anti-aging effect and preparation method thereof |
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2018
- 2018-05-25 CN CN201810511521.1A patent/CN108652991B/en active Active
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