CN1086444A - Electrochemical cancer and tumor therapeutic apparatus - Google Patents
Electrochemical cancer and tumor therapeutic apparatus Download PDFInfo
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- CN1086444A CN1086444A CN 93119769 CN93119769A CN1086444A CN 1086444 A CN1086444 A CN 1086444A CN 93119769 CN93119769 CN 93119769 CN 93119769 A CN93119769 A CN 93119769A CN 1086444 A CN1086444 A CN 1086444A
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Abstract
The present invention is made up of computer 1, bus conversion 2, D/A conversion 3, A/D conversion 4, voltage stabilization and current stabilization 5 and electrode needle circuit 6.Bus conversion 2 is connected between computer bus 7 and the instrument bus 8, and the input of D/A conversion 3 connects instrument bus 8, the anode of its output receiving electrode pin circuit behind voltage stabilization and current stabilization 5 and the input of A/D conversion, and the output of A/D conversion connects instrument bus.The present invention adopts the output of multichannel anode independence can treat the epimegetic tumor, also can treat a plurality of small-sized tumors or several patients simultaneously, but treatment parameter dynamic adjustments, and can write down, store, print the treatment data automatically.
Description
The present invention relates to treat the instrument of cancerous protuberance, especially a kind of electrochemical cancer and tumor therapeutic apparatus.
Domestic and international existing electrochemical cancer and tumor therapeutic apparatus generally all adopts the adjustable voltage stabilizing way of output, and majority only has one road anode output, is equipped with the output of 2～3 road negative electrodes (abroad as the Evaluation product of Sweden, Japan and Dutch Philips company; Domestic as WL, ZLY type etc.), minority has the output of two-way assistant anode, as the BA91 type.These therapeutic instruments exist following problems and shortcoming:
1. they select treatment voltage as primary controlled treatment parameter, and this is very unsuitable from electrochemical therapeutic cancer mechanism;
2. in treatment, flow through the treatment size of current very inconsistent sometimes (electric current maldistribution) of tumor tissues each several part, affect the treatment, even may make tumor accelerated growth on a certain direction;
3. owing to along with the adjusting of treatment voltage, present the feature of nonlinear change by the electric current of tumor tissues, this often makes the patient not adapt to, even therapeutic process is become be difficult to control;
4. assistant anode output way is few, can not give full play to the stronger therapeutical effect of anode, is unfavorable for further improving curative effect;
5. the treatment way is few, and effectively therapeutic domain is only below 5 centimetres;
6. the field data that provides for the user is less.
The purpose of this invention is to provide a kind of cancer and tumor therapeutic apparatus that computerizeds control and manage, have constant current of multichannel anode and multichannel negative electrode current-sharing output, its convenient and reliable operation is treated safe and effective.
The generation of design philosophy of the present invention is such:
1. by to the further research of electrochemotherapy mechanism, the design of at first clear and definite at home and abroad electrochemical therapeutic instrument for cancer device should be controlled as primary treatment parameter with effective treatment electric current, and should not select to treat voltage.Treatment voltage only should treatment parameter as a reference be subjected to monitoring and regulate, should not elect as main, can be given the parameter of putting.Like this could be more effectively more initiatively for the control of therapeutic process;
2. we find that in the electrochemical therapeutic cancer, anodic therapeutical effect is obviously strong than negative electrode by animal experiment, therefore should develop a kind of cancer therapeutic equipment that the output of multichannel (4-16 road) anode can be provided;
3. by analyzing the experience and lessons of summing up in the clinical treatment, on the basis of other electrochemical therapeutic instrument for cancer of analysis, we confirm to solve the problem of treatment electric current uniform distribution on tumor tumor body, each road anode should be designed to independently to control and to have the function of adjustable constant current output, and each road negative electrode then should have the function of euqalizing current;
4. whole therapeutic process should use the microsystem control and management, for satisfying various possible needs in the clinical treatment, and must perfect treatment control and the management software of development function.
Content of the present invention is summarized and is exactly: develop a kind of by the microsystem control and management, that have independent adjustable constant-flow output anode of multichannel (4-16 road) and multichannel (12-48 road) current-sharing negative electrode, manipulate more convenient reliable, treat safer and more effective model electrochemical cancer and tumor therapeutic apparatus.
The object of the present invention is achieved like this: electrochemical cancer and tumor therapeutic apparatus is made up of computer, bus conversion links, D/A converting unit, A/D converting unit, voltage stabilization and current stabilization link and electrode needle circuit.The electrode needle circuit is more than two-way, anode of each route and constitute more than the negative electrode flow equalizing circuit of two-way.Be used to realize that the electric mutual isolation between computer and the instrument and the bus conversion links of signal contact are connected between computer bus and the instrument bus, the input and the instrument bus of D/A converting unit join, its output is after the voltage stabilization and current stabilization link is handled, the anode of receiving electrode pin and the input of A/D converting unit respectively, the output of A/D converting unit hangs on the instrument bus.
The present invention in use, the overall process of instrument treatment is controlled and managed to computer in the following manner: computer is sent data and the control command that characterizes treatment current intensity from its bus, and deliver on the instrument bus through the bus conversion links, current data wherein converts analog quantity from instrument bus to through the D/A converting unit, exports from each electrode needle after the voltage stabilization and current stabilization link is stable.Treatment data such as the electric current that outfan presents, voltage, resistance, coulomb amount then are transmitted back on the instrument bus by the A/D converting unit, are sent in the computer through the bus conversion links again, by computer these treatment information are handled, are shown and regulate.Treatment finishes its result of back can printout.
Below in conjunction with drawings and Examples the present invention is elaborated.
Fig. 1 is a composition frame chart of the present invention;
Fig. 2 is the circuit theory diagrams of D/A converting unit and voltage stabilization and current stabilization link among the present invention;
Fig. 3 is an A/D conversion unit circuit schematic diagram among the present invention;
Fig. 4 is one of negative electrode flow equalizing circuit among the present invention;
Fig. 5 be among the present invention the negative electrode flow equalizing circuit two;
Fig. 6 is the current-sharing effect sketch map of negative electrode flow equalizing circuit among the present invention.
Cancer and tumor therapeutic apparatus among Fig. 1 is made up of computer 1, bus conversion links 2, D/A converting unit 3, A/D converting unit 4, voltage stabilization and current stabilization link 5 and electrode needle circuit 6.Bus conversion links 2 is made printed substrate and is inserted in the computer host box, eight road D/A conversion, 3, one road A/D conversion 4, eight road voltage stabilization and current stabilizations 5 and the electrode needle circuit 6 with the output of eight road assistant anodes and 30 two tunnel current-sharing negative electrodes all are placed in the therapeutic instrument cabinet, bus conversion links 2 is connected between computer bus 7 and the instrument bus 8, with electric mutual isolation and the signal contact that realizes computer and instrument; The input and the instrument bus 8 of D/A conversion 3 join, and its output is after voltage stabilization and current stabilization 5 is handled, and receiving electrode pin circuit 6 and A/D change 4 input; The output of A/D conversion 4 hangs on the instrument bus 8.
In Fig. 2, address decoder 19 and eight D/A converters 20 of the data buffer 18 that the D/A converting unit is joined by input port and instrument bus DB1, input termination instrument bus AB1 and CB1 are formed, it is identical eight the tunnel that the voltage stabilization and current stabilization link is divided into, and the placed in-line successively voltage stabilizing amplifier 21 of each route, current stabilization amplifier 22 and driver 23 are formed; Each path electrode pin circuit is formed (one road D/A converter that only draws among the figure, voltage stabilization and current stabilization link and electrode needle circuit) by the circuit with flow equalizing function 28 between an anode, four negative electrodes and every negative electrode and the circuit ground.Wherein: the output of data buffer 18 connects the data input port of each road D/A converter 20; The startup conversion foot of eight each road D/A converters 20 of output tap of address decoder 19; Two outputs of every road D/A converter 20 are connected to two inputs of corresponding voltage stabilizing amplifier 21, and the latter's output links to each other with the internal feedback foot of D/A converter 20, and voltage stabilizing amplifier 21 just is connected into negative feedback type like this.Current stabilization amplifier 22 is connected into homophase input dicyclo Current Negative Three-Point Capacitance form, its first feedback loop is made up of resistance R 1 between the emitter stage of in-phase input end that is connected on current stabilization amplifier 22 and driver 23 and R2 series arm, and its second feedback loop is made up of the resistance R 3 between the emitter stage of inverting input that is connected on current stabilization amplifier 22 and driver 23.The anode of each path electrode pin circuit is connected with the series connection point B of resistance R 1 and R2, and the end of corresponding four negative electrodes is through flow equalizing circuit 28 ground connection.The mechanism of action of dicyclo Current Negative Three-Point Capacitance is such: if variation (establishing load current reduces) has taken place load current, then in first feedback loop I is arranged
o↓ → I
i↓ → V
+↑ → V
b↑ → I
e↑ → I
o↑, in second feedback loop, I is arranged
o↓ → I
e↓ → V
-↓ → V
b↑ → I
e↑ → I
o↑, it is stable that the result of visible two ring feedbacks makes electric current obtain.
A/D converting unit among Fig. 3 is made up of the data sink 27 of channel selecting controller 24, variable connector 25, A/D converter 26 and the output termination instrument bus DB1 of input termination instrument bus DB1.The output of channel selecting controller 24 selects signal to connect the control input end of said variable connector 25, B among the figure as switch
i(i=1,2,8) be the output point B of each road voltage stabilization and current stabilization link among Fig. 2, they are connected to the signal input part of variable connector 25 respectively after each divider resistance dividing potential drop, the output of variable connector 25 connects the input of A/D converter 26, joins with data sink 27 data input ports after the A/D conversion.Channel selecting controller 24 is selected the 74LS273 latch for use among the figure; Variable connector 25 is selected CD4067 for use; A/D converter 26 is selected ICL7135 for use; Data sink 27 is selected 74LS244 for use.
Negative electrode flow equalizing circuit among Fig. 4 is made up of audion, last biasing resistance, base stage to forward between the ground placed in-line two diodes, emitter resistances.Its operation principle is: along with the increase of treatment electric current, the Vc value also increases in each road negative electrode flow equalizing circuit, as Vc ≈ 1.7V, during correspondence Ik ≈ 20mA, audion works in the saturation region, and flow equalizing circuit demonstrates stronger current-sharing effect, and promptly Vc increases big and Ik increases very little, so the treatment electric current just flows to the lower negative electrode of Vc value from Vc value high cathode through cancerous tissue, thereby plays the effect of uniform distribution electric current between negative electrode.
If change two diodes among Fig. 4 into two Zener diodes, then current-sharing effect and stability are better.
Negative electrode flow equalizing circuit among Fig. 5 is made up of audion, last biasing resistance and emitter resistance, and the base stage of audion also is connected to D/A converter together in each negative electrode flow equalizing circuit.
Its operation principle is:
1) by the negative electrode number that uses in the program scanning inspection treatment;
2) calculate current values (negative electrode average current value) Ik:Ik=anode total current/negative electrode number that one road negative electrode should pass through
3) program obtains the digital quantity of cathodic electricity flow valuve correspondence by calculating or tabling look-up;
4) carry out suitable D/A conversion with this digital quantity, control the base potential of audion in each flow equalizing circuit.
Because component parameter has kept concordance in each flow equalizing circuit, so can realize the negative electrode flow equalizing function, compare with aforementioned circuit, this circuit current-sharing wider range, all stream error is little, better effects if.
The current-sharing effect of negative electrode flow equalizing circuit after anode current Ia enters the tumor body, flows to each road negative electrode along different approach as shown in Figure 6.May present from anode to each road negative electrode different resistance (Rc1, Rc2 ... Rcn).Between the end of every cathode needle and circuit ground, insert flow equalizing circuit 28, when certain road cathode current Iki is increased to the Vci value during more than or equal to 1.7V that makes this road, this road flow equalizing circuit enters the operate in saturation district, Iki only has a little increase, Vci will increase a lot, can flow to the lower cathode needle of Vc value by the cancerous tissue Rcc between the cathode needle so flow to the electric current of this road cathode needle, make the treatment electric current between each road negative electrode, obtain distributing more uniformly.
The treatment principle of this instrument foundation is: insert positive and negative electrode (being the positive and negative utmost point) on tumor tissues, unidirectional current is flowed into from anode, flow out from negative electrode behind tumor tissues.Under this unidirectional current electric field action, the pH value generation acute variation of tumor cell tissue, the anode region pH value reduces to 1～2, be highly acid, the cathode chamber pH value rises to 12～14, is strong basicity, cause cancer cell membrane collapse, mitochondrion disappearance, nucleoprotein coagulation necrosis, thereby tumor tissues is destroyed.Treat electric current and export, to guarantee that treatment safety is with effective by the trapezoidal wave of slowly rising → maintenance → slowly decline.
The following describes the operation principle of instrument of the present invention:
Computer is sent data and the control commands corresponding that characterizes treatment channel number, treatment current intensity from its bus, and deliver on the instrument bus through the bus conversion links, treatment channel number wherein starts corresponding D/A converter, convert the current data on the instrument bus to analog quantity, again after the voltage stabilization and current stabilization link is stable, from the anode pin output on corresponding road.The magnitude of voltage that outfan presents is delivered to A/D converter through divider resistance from multidiameter option switch, is transmitted back to the computer from instrument bus, bus conversion and computer bus successively after conversion, and computer processs and displays these data.Computer is pressed said process and is sent the treatment data to next passage then, and the treatment information of fetching this passage processs and displays.So being circulated to last passage disposes.Then computer is progressively sent the treatment electric current that numerical value increases gradually by above process by each passage again, till the treatment electric current reaches predefined numerical value.Make each passage keep this treatment electric current output a period of time, after a treatment coulomb amount reaches set-point, the treatment electric current is descended gradually, when electric current reduced to zero, therapeutic process promptly came to an end.Various treatment information such as channel number, electric current, voltage, resistance, coulomb amount are all with screen display in the therapeutic process, and the doctor can regulate at any time, and last therapeutic outcome can be from printer output.
The invention has the advantages that:
1. the present invention has selected effective treatment electric current as a main controlled treatment parameter of electrochemical therapeutic cancer technology, treatment voltage then is subjected to monitoring and regulates as the treatment parameter of a reference, thereby making therapeutic process more meet the desirability of electrochemical therapeutic cancer mechanism, the doctor is to the more effectively more active of control for the treatment of;
2. the present invention has the anode of 8 tunnel independence adjustable constant currents output, and the negative electrode of 32 road band flow equalizing functions is arranged, and therapeutic process is by the microsystem control and management. This therapeutic equipment can distribute for the patient treatment position provides more perfect treatment electric field and more even rational electric current, can solve preferably the local treatment of tumor underdosage, so that the problem of residual cancer cell; And multianode employing, be conducive to give full play to the stronger therapeutic action of anode, be conducive to further improve curative effect;
3. the volume of this therapeutic equipment seance tumour can reach 11 centimetres of diameters, is maximum in present various ECT cancer therapeutic equipments; This therapeutic equipment also can be treated simultaneously several tumor mass or be treated simultaneously two patients;
4. the present invention is furnished with computer, therefore can be for the user provide more comprehensively abundanter clinical treatment information, and it uses function more to adapt to the actual needs of electrochemistry clinical treatment, and more convenient operation is reliably treated safer and more effective.
Claims (5)
1, electrochemical cancer and tumor therapeutic apparatus has computer (1), D/A changes (3), A/D changes (4) and electrode needle circuit (6), it is characterized in that it also comprises bus conversion (2) and (5) two links of voltage stabilization and current stabilization, said electrode needle circuit (6) is more than two-way, anode of each route and constitute more than the negative electrode flow equalizing circuit of two-way, be used to realize that the electric mutual isolation between computer and the instrument and the bus conversion (2) of signal contact are connected between computer bus (7) and the instrument bus (8), the input and the instrument bus (8) of D/A conversion (3) join, its output is after voltage stabilization and current stabilization (5) is handled, the input of the anode of receiving electrode pin (6) and A/D conversion (4) respectively, the output of A/D conversion (4) hangs on the instrument bus (8).
2, electrochemical cancer and tumor therapeutic apparatus according to claim 1, it is characterized in that said bus conversion (2) is by multichannel optical coupler (9), address latch (10), write data latch device (11), read data (12), control signal generator (13), address buffer (14), data write buffer (15), data read buffer (16) and control signal drivers (17) are formed, wherein: the address signal of instrument by computer successively from computer bus DB, address latch (10), optical coupler (9), address buffer (14) is delivered on the instrument bus AB1; As calculated write instrument bus DB1 on successively by machine bus DB, write data latch device (11), optical coupler (9), data write buffer (15) for the data signal of computer; The data signal of instrument is delivered on the data/address bus DB of computer through its bus DB1, data read buffer (16), optical coupler (9), read data (12) successively; As calculated deliver to instrument bus CB1 on successively by machine bus DB, control signal generator (13), optical coupler (9) and control signal drivers (17) for the data signal of computer.
3, electrochemical cancer and tumor therapeutic apparatus according to claim 1, it is characterized in that data buffer (18), input termination instrument bus AB1 and CB1 that said D/A conversion (3) is joined by input port and instrument bus DB1 address decoder (19), reach eight D/A converters (20) and form, the output of said data buffer (18) connects the data input port of each D/A converter (20), the startup conversion foot of each output each D/A converter of tap (20) of said address decoder (19).
4, electrochemical cancer and tumor therapeutic apparatus according to claim 1, it is characterized in that said voltage stabilization and current stabilization link (5) is divided into identical eight the tunnel, the placed in-line successively voltage stabilizing amplifier of each route (21), current stabilization amplifier (22) and driver (23) are formed, the output of the input of said voltage stabilizing amplifier (21) and said D/A conversion (3) is joined, the input of the output receiving electrode pin circuit (6) of said driver (23) and A/D conversion (4).
5, electrochemical cancer and tumor therapeutic apparatus according to claim 1, it is characterized in that the channel selecting controller (24) of said A/D conversion (4) by input termination instrument bus DB1, variable connector (25), the data sink (27) of A/D converter (26) and output termination instrument bus DB1 is formed, the output of said channel selecting controller (24) selects signal to connect the control input end of said variable connector (25) as switch, the signal input part of the output signal of said voltage stabilization and current stabilization link (5) and said variable connector (25) joins, the latter's output signal inserts the input of said A/D converter (26), and the input port with said data sink (27) after the A/D conversion joins.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93119769 CN1086444A (en) | 1993-06-12 | 1993-11-06 | Electrochemical cancer and tumor therapeutic apparatus |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93106925 CN1078649A (en) | 1993-06-12 | 1993-06-12 | Intelligent medical instrument for therapy of cancer |
| CN93106925.4 | 1993-06-12 | ||
| CN 93119769 CN1086444A (en) | 1993-06-12 | 1993-11-06 | Electrochemical cancer and tumor therapeutic apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1086444A true CN1086444A (en) | 1994-05-11 |
Family
ID=25743039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93119769 Withdrawn CN1086444A (en) | 1993-06-12 | 1993-11-06 | Electrochemical cancer and tumor therapeutic apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1086444A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997039793A1 (en) * | 1996-04-22 | 1997-10-30 | Beijing Haidian Dadi Electronic Technology Development Corp. | An electrochemic cancer treat device |
| WO1998022181A1 (en) * | 1996-11-18 | 1998-05-28 | Hongbing Pang | An instrument of electrochemical therapy for cancer |
-
1993
- 1993-11-06 CN CN 93119769 patent/CN1086444A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997039793A1 (en) * | 1996-04-22 | 1997-10-30 | Beijing Haidian Dadi Electronic Technology Development Corp. | An electrochemic cancer treat device |
| WO1998022181A1 (en) * | 1996-11-18 | 1998-05-28 | Hongbing Pang | An instrument of electrochemical therapy for cancer |
| CN1038729C (en) * | 1996-11-18 | 1998-06-17 | 庞宏冰 | Electrochemical therapeutic instrument for cancer |
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| PB01 | Publication | ||
| C03 | Withdrawal of patent application (patent law 1993) | ||
| C12 | Rejection of a patent application after its publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| C03 | Withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |