CN1163150A - Electrochemical therapeutic instrument for cancer and tumour - Google Patents

Abstract

The therapeutic instrument includes computer, keyboard, displayer, bus converting circuit board inserted inside computer, therapeutic system device and electrode pin. The said therapeutic system device includes DC current output unit comprising multiple-routing D/A convertor circuit and constant current output circuit, multiple DC stabilizer unit, negative pole current equalizing circuit matching the constant current output circuit, and A/D convertor circuit. The said instrument has current as main controlled parameter and the current is controlled in 20-100 mA to result in high therapeutic effect. It has also emergency treatment device and this makes it safe and reliable.

Description

Electrochemical cancer and tumor therapeutic apparatus

The present invention relates to a kind of Medical Instruments, particularly a kind ofly utilize unidirectional current, make the sick body tissue that biochemical reaction take place, thereby destroy the electrochemical cancer and tumor therapeutic apparatus of sick body tissue (as tumor) as treatment means.

Existing electrochemical cancer and tumor therapeutic apparatus generally is to adopt the adjustable voltage way of output, and this selection voltage is primary controlled treatment parameter, is not too suitable from electrochemical therapeutic cancer mechanism.Simultaneously, in treatment, flow through tumor tissues each several part electric current maldistribution, directly affect the treatment, even can make certain a part of tumor accelerated growth.

Applicant had once applied for to Patent Office of the People's Republic of China that a key name was called " electrochemical cancer and tumor therapeutic apparatus " in December in 1993 3 days, application number is 93120059.8, this application is open in advance in June, 1994, in above-mentioned application, introduced a kind of with the treatment electric current be main, can be given the electrochemical cancer and tumor therapeutic apparatus of putting the treatment parameter, its main feature is that it can provide multichannel constant anodal treatment electric current, and the electric current of uniform distribution is provided for the multichannel negative pole.But in this application, though provide as the constant-current device circuit theory diagrams for the treatment of signal generation device, therefore the electrochemical cancer and tumor therapeutic apparatus that provides a kind of performance outstanding is not provided the preferred plan of report enforcement.

The object of the invention provides a kind of electrochemical cancer and tumor therapeutic apparatus, and this therapeutic instrument therapeutic effect is good, safe and reliable.

For achieving the above object, the present invention by the following technical solutions: electrochemical cancer and tumor therapeutic apparatus comprises computer; With supporting display, the keyboard of computer; Insert a bus switching circuit plate in the computer, bus switching circuit is connected with computer bus, treatment host bus; Treatment main frame and electrode needle, described treatment main frame comprises: the DC current output unit that multirouting D/A change-over circuit, constant current output circuit are formed; The multi-channel DC voltage stabilization unit, it is made of wave filter, transformator, direct current stabilizer; The a plurality of negative pole flow equalizing circuits that match with constant current output circuit; The A/D change-over circuit, described constant current output circuit comprises an operational amplifier and a driver, two diodes that described flow equalizing circuit comprises audion, goes up biasing resistance, forward is connected in series between emitter resistance and base stage and the ground, described electrode needle comprises anodal A and a plurality of negative pole C.

The invention will be further described below in conjunction with accompanying drawing:

Fig. 1: the operation principle block diagram of therapeutic instrument of the present invention

Fig. 2: the circuit theory diagrams of the DC current output unit of therapeutic instrument of the present invention

Fig. 3: the circuit theory diagrams of therapeutic instrument negative pole flow equalizing circuit of the present invention

Among Fig. 1,3 is computer, and 1,2 is display, the keyboard supporting with computer, inserts a bus switching circuit plate 4 in the computer, it transmits the signal between computer and the treatment main frame, and it is connected between computer and the treatment main frame by computer bus and instrument bus 12.Treatment main frame 5 comprises: by the DC current output unit that D/A change-over circuit 6, constant current output circuit 7 constitute, this output unit is a multichannel, can select for use as required; Also comprise multi-channel DC voltage stabilization unit 10 in the main frame, it contains wave filter, transformator, direct current stabilizer, the following safe voltage of exportable 36V, needed treatment electric current output is regulated and control, is converted to the electric current under the safe voltage (milliampere level) through instrument each several part circuit; Among Fig. 1,9 is the flow equalizing circuit of negative pole, it and constant current output circuit 7 constitute treatment unit (seeing Fig. 3 for details), also comprise electrode needle 8 among Fig. 1, it adopts metal material corrosion-resistant, that conduct electricity very well to make, preferably the platinum group metal is serially connected between the positive and negative electrode by treatment target, also comprises the A/D change-over circuit in the main frame.

Above-mentioned bus switching circuit comprises: address latch, write data latch device, address buffer, data write buffer, read data, the data read buffer, also has the control signal generator, wherein, the control signal generator is used to produce the required control signal in treatment unit, and these control signals are delivered to the treatment unit through control signal drivers.In addition, also have a control signal generator, it is to provide chip selection signal for buffer and latch etc. in the bus switching circuit.

Above-mentioned A/D change-over circuit comprises: the channel selecting controller that input links to each other with data/address bus, multicircuit switch, the A/D conversion chip, and the data sink of the numerical data outfan of output termination data/address bus and input termination A/D conversion chip, the input of the output termination A/D conversion chip of multicircuit switch, channel controller is used to select the passage of multicircuit switch.

Among Fig. 2,6 is the D/A change-over circuit, and this circuit comprises data buffer, address decoder, D/A conversion chip, operational amplifier 13, and wherein D/A conversion chip and operational amplifier are a plurality of, decide on output group number.The output of D/A conversion chip connects operational amplifier, the reference voltage VREP of chip is directly provided by the stabilivolt of voltage regulation unit, the model of operational amplifier is μ A741, the output of operational amplifier 13 connects another operational amplifier 14 (shared μ A741), driver connected (S8050) 15 of 14 output, wherein the colelctor electrode of audion connects+the 24V adjustable voltage.

The anodal electric current of every road constant current output circuit is between the 20mA-100mA, and it is not obvious to be lower than the 20mA therapeutic effect, is higher than 100mA and is unfavorable for patient and safety.

Be to adapt to emergency, connect+the 24V adjustable voltage on the transistor collector of the driver 15 of this therapeutic instrument, use adjustable potentiometer, potentiometer is fixed on the front panel for the treatment of main frame.When the state of emergency occurring, potentiometer can be transferred to null value, anodal output current is close to zero, to guarantee patient's personal safety.

Among Fig. 3, after the DC current Ia feeding focus by the anodal output in a certain road, the audion T in flow equalizing circuit, resistance R ₉, ground connection, wherein connecting resistance R between the base stage of audion and the colelctor electrode ₈, two diode D1 of serial connection between base stage and ground.

Anodal treatment electric current I a enters the tumor body, and when certain road cathodal current Iki was increased to the Vci ≈ 1.7V that makes this road, this road negative pole flow equalizing circuit was operated in saturation, and at this state, promptly Vci increases big and I _KiIncrease very little, so the treatment electric current that flows to this road negative pole and increase can flow to V by the cancerous tissue between the negative pole _CiBe worth lower negative pole, promptly treat electric current and between each road negative pole, obtain uniform distribution.Constant-current circuit satisfies following formula $\mathrm{Ia}=\frac{\mathrm{Vi}}{R_7}(1+\frac{R_7}{2R_6})\≈\frac{\left|V_{\mathrm{REF}}\right|}{R_7}\·\frac{D}{256}$

R wherein ₃=R ₄R ₅=R ₆+ R ₇

In the formula: Ia: the anodal treatment electric current of flowing through

The numerical data input of D:D/A change-over circuit 6

Its numerical value is taken between the 0-255

V _REF: the reference voltage of D/A change-over circuit 6 is provided by stabilivolt

According to practical application, R in this circuit ₃=R ₄=R ₅=10K Ω, R ₆=9.95K Ω, R ₇=50 Ω, the output current of full scale value are 99.86mA.Change the value of D, so that constant current output is controlled between the 20mA-100mA, in this current value, this therapeutic instrument can obtain fine therapeutic effect.

The work process of this therapeutic instrument: after computer is provided with by software, to characterize the treatment channel number by bus conversion unit, the treatment data and the corresponding control command of treatment current intensity are delivered on the instrument bus, D/A on the treatment main frame converts analog quantity to, again through the positive pole output of constant current from corresponding road, the voltage that outfan presents is through A/D, conversion of conversion bus and computer bus are got back to computer, computer is handled these data, show, all the other each passages carry out successively, in the therapeutic process, the size of treatment electric current is regulated by computer self, control, can make the treatment electric current be trapezoidal wavy change generally speaking, promptly from the little current value that slowly rises to setting, after keeping a period of time, slowly drop to zero again, by computer regulated, the all processes of control and management treatment.

The mechanism of action: pass through electrochemical therapeutical instrument, impose the treatment electric current for tumor or sick body tissue, when injected organism tissue produces a series of biological electrolysis, ionization, electro-osmosis reaction, and produce more complicated biochemical reaction thus, consequently: (1) tumor or other sick body tissues, positive polar region pH value is reduced to 1-2, is highly acid, negative pole district pH value rises to 12-14 and is strong basicity, and the acid that the sick body cell is depended on for existence, soda balance environment thoroughly destroy.(2) sick body cell membranes in tissue ulceration, mitochondrion disappears, the nucleoprotein coagulation necrosis.(3) violent acid, alkali reaction and cell protein coagulation necrosis in the sick body tissue causes sick body to organize inner blood and the microcirculatory stagnation of body fluid again.(4) under the primary condition that above-mentioned sick body cell is depended on for existence is suffered thoroughly the destruction situation, tumor or other sick body histiocyte death, thus cause tumor or other sick body tissues thoroughly to destroy.

Advantage of the present invention: it is main control parameters that this therapeutic equipment adopts DC current, is conducive to treatment, and electricity Flow valuve is controlled at the 20mA-100mA range, has greatly improved result for the treatment of, and therapeutic equipment also is provided with Treating apparatus under the state of emergency (0～+ the output adjustable voltage of 24V), output treatment electric current is approached Zero, the security of therapeutic equipment, Reliability Enhancement have guaranteed personal safety. Adopt the metal material conducts such as platinum Electrode has also guaranteed the reliability of instrument, and has increased the service life.

Claims (5)

1, a kind of electrochemical cancer and tumor therapeutic apparatus, it comprises computer (3); With supporting display (1), the keyboard (2) of computer; Insert a bus switching circuit plate (4) in the computer, bus switching circuit is connected with computer bus, treatment host bus (12); Treatment main frame (5) and electrode needle (8) is characterized in that described treatment main frame comprises: the DC current output unit that multirouting D/A change-over circuit (6), constant current output circuit (7) are formed; Multi-channel DC voltage stabilization unit (10), it is made of wave filter, transformator, direct current stabilizer; The a plurality of negative pole flow equalizing circuits (9) that match with constant current output circuit (7); A/D change-over circuit (11), described constant current output circuit comprise an operational amplifier (14) and a driver (15), and described flow equalizing circuit comprises audion, goes up biasing resistance R ₈, emitter resistance R ₉And two diodes that forward is connected in series between base stage and the ground, described electrode needle comprises anodal A and a plurality of negative pole C.

2, electrochemical cancer and tumor therapeutic apparatus according to claim 1 is characterized in that: the anodal electric current of described every road constant current output circuit is between the 20mA-100mA.

3, electrochemical cancer and tumor therapeutic apparatus according to claim 1 and 2 is characterized in that: the parameter in the described constant current output circuit (7) is R ₈=R ₄=R ₅=10K Ω, R ₆=9.95K Ω, R ₇=50 Ω.

4, electrochemical cancer and tumor therapeutic apparatus according to claim 1 and 2 is characterized in that: described driver (15) adopts audion, and the colelctor electrode of audion connects+the 24V adjustable voltage.

5, electrochemical cancer and tumor therapeutic apparatus according to claim 1 and 2 is characterized in that: described electrode needle is preferably selected the platinum family material for use.

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