CN108635369A - A kind of efficient liver, intestinal regeneration agent and bait - Google Patents
A kind of efficient liver, intestinal regeneration agent and bait Download PDFInfo
- Publication number
- CN108635369A CN108635369A CN201810415802.7A CN201810415802A CN108635369A CN 108635369 A CN108635369 A CN 108635369A CN 201810415802 A CN201810415802 A CN 201810415802A CN 108635369 A CN108635369 A CN 108635369A
- Authority
- CN
- China
- Prior art keywords
- parts
- added
- fine
- feed liquid
- glycine betaine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/26—Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
- A23K10/38—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material from distillers' or brewers' waste
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/22—Compounds of alkali metals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
A kind of efficient liver, intestinal regeneration agent, include the raw material of following parts by weight：40 50 parts of glycine betaine and its derivative；58 parts of tributyrin；It is electrolysed 8 10 parts of multidimensional；20 30 parts of starch；8 10 parts of silica.The present invention discloses the raw materials of a kind of bait, including following parts by weight to be prepared：0.2 0.5 parts of renovation agent；20 30 parts of dried silkworm chrysalis meal；0.5 0.8 parts of egg-shell meal；10 15 parts of soybean cake dregs；38 parts of wheatfeed；25 parts of cereal vinasse；0.5 0.9 parts of soybean oil；58 parts of spirulina powder；9 15 parts of alginic acid.The present invention restores liver function, repairs liver sausage cell, detoxication and toxicant eliminating function, reduces fat, and accelerates the speed of production of various enzymes in liver, rebuilds intestinal beneficial flora；To restoring enteron aisle liver function rapidly, improving anti-stress ability has obvious effect.
Description
Technical field
The present invention relates to a kind of field of feed additive technology more particularly to efficient liver, renovation agent and bait.
Background technology
Currently, a variety of technologies glycine betaine being applied in feed addictive occur, such as：Application No. is
201410267447.5 patent discloses a kind of compound premix for laying period of layers improving intestinal health state, by following heavy
Measure the raw material composition of number：20-40 parts of carrier, 15-25 parts of calcium monohydrogen phosphate, 10-20 parts of zeolite powder, 3-15 parts of rapeseed dregs, salt
4-8 parts, 2-5 parts of stomach invigorating acid, 2.0-3.5 parts of DL- METHIONINE, 1.0-3.5 parts of composite trace element inhales mould 1.5-3 parts of spirit, compound
1.0-2.0 parts of enzyme preparation, 0.8-2 parts of probiotics, 0.6-2 parts of choline chloride, 0.4-1.2 parts of multi-vitamins, and U.S. effect
It is 0.4-1.0 parts plain, 30 0.4-0.7 parts of glycine betaines, fresh 0.1-0.15 parts of No. 5 pulvis；The carrier is sawdust, rice chaff, clover
The cellulose families raw material such as powder.Application No. is 201410092186.8 patents, disclose a kind of Procambius clarkii juvenile prawn phagostimulant
And its preparation method and application.The phagostimulant contains in parts by weight at being grouped as：30~40 parts by weight of glycine betaine, oxidation three
15~25 parts by weight of methylamine, 15~20 parts by weight of dimethyl-β-thiopropionate, 20~30 parts by weight of allicin.Preparation method
It is to be sufficiently mixed after weighing each component in parts by weight.Raw material sources of the present invention are stablized, simple production process, and materials are extensive, at
This is cheap, with obvious effects；And from the ingesting of shellfish, digest mechanism, when use, can effectively improve ingesting for shrimp body
Rate reduces bait waste, while can also improve the digestive enzyme activity of Procambius clarkii enteron aisle and pancreas, promotes shrimp growth.Application
Number patent for being 201310664980.0, discloses a kind of nutrition fish-prawn-crab feed formula, includes following raw material in every part of feed
Formula：Fish meal 25-30g, dregs of beans 20-23g, peanut meal 10g, shrimp shell meal 5g, oyster shell whiting 1g, cotton dregs 3g, meat meal tankage 2g, dried noodle
16-18g, yeast powder 2-3g, fish oil 1g, skin chaff 3-4g, premix 1g, choline 0.1g, natural glycine betaine 0.2g, phosphonic acids potassium dihydrogen
1.8-2g, seawood meal 0-0.2g, shelling element 0.1g, garlic 0.05g, lactic acid gemma 0.2g, producing enzyme probiotic 0.2g, adhesive
0.3g, salt 0.2g.The formula of the present invention helps fish shrimp crab while replenishing the calcium using garlic, lactic acid gemma, producing enzyme probiotic
Enteron aisle digests and immune, raising survival rate and tachyauxesis, guarantee economic benefit.
But inventor has found under study for action：During the animal-breedings such as livestock and poultry, aquatic products, often it will appear because various
Liver and gall lesion, intestinal epithelial mucosal cell damage and intestinal villus fall off caused by reason, to influence the normal machine of cultivated animals
Energy metabolism, causes that cultivated animals are slow-growing, hypoimmunity, and severe patient occurs dead.
And current disclosed technology, majority are started with for bacterium colony, the enzyme etc. in enteron aisle, keep the health status of enteron aisle,
Improve the digestion power of the animals such as livestock and poultry, aquatic products.But " liver and gall lesion, intestinal epithelial mucomembranous cell damage for having occurred
Wound and intestinal villus fall off " animals such as livestock and poultry, the aquatic products of symptom its effects is not obvious.
Therefore, a kind of efficient liver of exploitation, intestinal regeneration agent, not only have urgent researching value, it may have good
Economic benefit and commercial application potentiality, where this power that exactly present invention is accomplished and basis.
Invention content
In order to overcome the defect of the prior art as indicated above, the present inventor to have made intensive studies this, paying
After a large amount of creative works, so as to complete the present invention.
Specifically, the technical problem to be solved by the present invention is to：A kind of efficient liver, intestinal regeneration agent are provided, with right
The animals such as the livestock and poultry, aquatic products of " liver and gall lesion, the intestinal epithelial mucosal cell damage and intestinal villus fall off " symptom occurred into
Row effectively treatment.
In order to solve the above technical problems, the technical scheme is that：
A kind of efficient liver, intestinal regeneration agent, include the raw material of following parts by weight：
40-50 parts of glycine betaine and its derivative；
5-8 parts of tributyrin；
It is electrolysed 8-10 parts of multidimensional；
20-30 parts of starch；
8-10 parts of silica.
In the present invention, glycine betaine seemingly, mainly passes through as a kind of amino acid to methylate, beet Alkali absorption with amino acids
Glycine betaine-γ-aminobutyric acid movement system and amino acid transporter system A are transported through, absorption efficiency of the glycine betaine in enteron aisle
Very high, glycine betaine enters each tissue of body through blood circulation after being absorbed in enteron aisle and decomposes or organizing by metabolic pathway
Middle deposition.Glycine betaine-homocysteine-transmethylase (BHMT) is mainly distributed on animal's liver, kidney and eye tissue.
Under the catalysis of BHMT, glycine betaine provides a methyl with synthetic methionine for homocysteine, and then generates dimethylglycine,
Then it further decomposes and generates many secondary metabolites, such as sarcosine, glycine, serine.Homocysteine is by BHMT
Regulate and control with cystathionie-beta-synthetase (Cystathionine- β-synthase, C β S).Homocysteine methylates again generates egg
Propylhomoserin, the process are known as the approach that methylates again of methionine.It is methionine that glycine betaine participates in methionine generation under BHMT effects
One of important channel to methylate again, this saves methionine, releases the toxicity of homocysteine and generates S- adenosine first to body
Methyllanthionine (S-adenosylmethionine, SAM) is all of great significance.In addition, homocysteine also can be in the catalysis of C β S
Lower generation cysteine, then participates in the synthesis of the substances such as glutathione, cystine, taurine, this process is known as methionine
Turn sulphur approach.Studies have shown that the content of BHMT in liver can be significantly improved by adding glycine betaine in daily ration, accelerate methionine again
It methylates, improves methionine and SAM contents；And C β S vigor can be improved, accelerate methionine to turn sulphur approach, promotes cystine, ox sulphur
The important metabolite such as acid, glutathione generates.Glycine betaine and its derivative can also play identical effect.
Tributyrin slow release under the action of pancreatic lipase repairs intestinal villi at butyric acid and glycerine, inhibits
Harmful intestinal tract bacteria promotes the absorption and utilization of nutriment.Intestinal mucosa has the physiological function for absorbing nutriment and immune screen
Barrier acts on.Gut barrier plays key effect in the absorption of nutriment and control and prevention of disease.Intestinal mucosa is growth of animal
Most fast one of the tissue of update in the most fast tissue of early development and animal body, quick growth and development and continuous renewal need
Want the effective energy and with various nutrients.Therefore, intestinal mucosa is tissue most sensitive to nutrient in animal body, some stress
The reparation of intestinal mucosa injury caused by factor is with greater need for the energy and nutrient.Energy will be saved by reducing the update of enterocyte
For growing, effective energy is gut epithelium normally newer guarantee.
Multidimensional purchase is electrolysed in market.It, which is acted on, can supplement multivitamin, enhance premunition, while can also prevent
The stress reaction that " liver and gall lesion, intestinal epithelial mucosal cell damage and intestinal villus fall off " occurs is prevented vitamin-deficiency, is carried
The high price of deed enhances premunition, improves survivability of chicks.The factors such as pre- anti-rotation group, vaccine inoculation, Changes in weather, disconnected beak are drawn
The stress reaction risen.It when poultry falls ill, can be used as auxiliary treatment, be conducive to the rehabilitation of disease.
Starch enables to medicament to split the substance for being broken into fine particle rapidly in gastro-intestinal Fluid, plays the effect that slow (control) is released
Fruit.And since starch has very strong water swellability in the present invention can be by the knot between glycine betaine and other components
Resultant force is disintegrated, and is allowed to split from the tablet of an entirety and is broken into many tiny particles, is advantageous to dissolve and absorb.
Likewise, silica can play the effect of resistive connection, the caking of renovation agent is avoided.
In the present invention, as an improvement, the renovation agent includes the raw material of following parts by weight：
42-48 parts of glycine betaine and its derivative；
6-8 parts of tributyrin；
It is electrolysed 9-10 parts of multidimensional；
22-27 parts of starch；
8-9 parts of silica.
In the present invention, as an improvement, the renovation agent includes the raw material of following parts by weight：
45 parts of glycine betaine and its derivative；
7 parts of tributyrin；
It is electrolysed 10 parts of multidimensional；
25 parts of starch；
8 parts of silica.
In the present invention, as an improvement, the glycine betaine and its derivative use fine glycine betaine, the glycine betaine to spread out
Biology includes beet alkali hydrochlorate, betaine phosphate, beet alkali citrates etc..
In the present invention, as an improvement, the fine glycine betaine is to be obtained using the preparation method included the following steps
Product：
In the autoclave body with stirring, the calcium hydroxide suspension for the 30wt% that addition is made into calcium hydroxide；Stir water
Under bath is cooling, the aqueous solution for the 20wt% that monoxone is made into is instilled, calcium chloroacetate aqueous solution is obtained；
Calcium chloroacetate aqueous solution is filtered to remove impurity, is imported in the autoclave body that one carries condensing reflux, blender, room temperature stirs
It mixes down, the trimethylamine aqueous solution of 30wt% is added dropwise, normal-temperature reaction is warming up to 55 DEG C of reaction 0.8h, then heats up simultaneously after 25 minutes
Control temperature reacts 1.5h at 80 DEG C, obtains glycine betaine and CaCl2Mixed liquor；
By Ag2CO3Solution is poured into while stirring in the mixed liquor of glycine betaine and calcium chloride, that is, generates white precipitate；Stand three
Minute, it filters, filtrate is the aqueous solution of glycine betaine, is boiled, and concentration (if any Precipitation in concentration process, still needing to filter) is extremely
Solution clear viscous, at 85 DEG C vacuum drying remove minor amount of water, up to fine glycine betaine.
In the present invention, as an improvement, the fine glycine betaine can also be using the preparation side included the following steps
The product that method obtains：
Mother liquor after beet sugar manufacture is heated to 55-65 DEG C, calcium chloride is added with stirring at 120-150 revs/min, while hot
Filtering, addition hydrochloric acid to filtrate muddiness no longer generates in filtrate, is then crystallized at 20-30 DEG C, detaches, dries, and obtains thick
Product glycine betaine；
Crude product is dissolved into water and obtains feed liquid, feed liquid is added to the fresh water compartment of electric drive membrane separator, and to
Deionized water is added into concentrated water compartment until conductivity is 50000us/cm for interior plus deionized water, opens electric drive UF membrane
Device obtains fine feed liquid until the conductivity of feed liquid is 2500us/cm；
The fine feed liquid is handled using electrodialysis apparatus：Fine feed liquid is added in fresh water compartment, concentrated water compartment,
The sodium chloride solution of pole water configuration 10000us/cm, operating flux 500L/h, holding voltage is 40.3V, and electric current 2.9A is followed
Ring is handled 120-150 minutes, and what is obtained in fresh water compartment is fine alkali solution of beet, and fine alkali solution of beet is depressurized and is steamed
It evaporates, crystallize, obtain fine glycine betaine.
In the present invention, as an improvement, the beet alkali hydrochlorate is using the production for including the following steps to be prepared
Product：
By fine alkali solution of beet obtained above, concentrated hydrochloric acid is added dropwise under stiring, no longer disappears until there is emulsion
Until, it is placed 24-36 hours at 50-60 DEG C, is cooled to 30-35 DEG C, until beet alkali hydrochlorate crystallization is precipitated, filtering, solid is used
The ethanol solution that mass fraction is 50% washes twice, and obtains beet alkali hydrochlorate.
The beet alkali hydrochlorate can also be using the product for including the following steps to be prepared：
Monoxone and n,N-Dimethylformamide, stirring are added in the three-necked flask equipped with stirring, reflux condenser to be made
It obtains monoxone to be completely dissolved, 33% trimethylamine aqueous solution is added in single-necked flask, heats trimethylamine aqueous solution, uses condenser pipe
Cooling gas, and gas is slowly introducing by drying device in the flask for filling chloroacetic acid solution, control temperature is not when ventilation
More than 20 DEG C, residual air is exported by reflux condenser upper end rubber tube and is recycled, 60 DEG C are warming up to after ventilation, isothermal reaction
5h is filtered after reaction, and vacuum drying obtains white powdery solids；Ethyl alcohol is added in single port bottle, adds above-mentioned white
Color pulverulent solids, stirring and dissolving, vacuum distillation, obtain beet alkali hydrochlorate.
Wherein, betaine phosphate is using the product for including the following steps to be prepared：
It is characterized in that this method is that monoxone is made into the aqueous solution of 20-40%, it is placed in reactor, starts stirring,
It is neutralized to pH4.0-5.0 with the sodium hydrate aqueous solution of 15-30% or sodium carbonate and sodium chloroacetate solution is made；It is subsequently cooled to
10-30 DEG C, the trimethylamine aqueous solution of 25-40% is added or is passed through front three amine gas, the molar ratio of sodium chloroacetate and trimethylamine is 1
: 1.00-1.20, control temperature are reacted 5-7 hours at 30-60 DEG C；Multiply heat filtering after reaction solution concentration and remove sodium chloride, uses 30-
85% phosphoric acid tune pH to 2.0-2.5, crystallisation by cooling filtering, obtains betaine phosphate.
Wherein, beet alkali citrates are using the product for including the following steps to be prepared：
Citric Acid Mono is added in fine alkali solution of beet, is stirred 4-5 hours at room temperature, until pH value of solution is 3-4,
It is concentrated in vacuo at 1/3,25-30 DEG C of original volume and crystallizes 6-7 hours at 83-86 DEG C, obtain white crystal, centrifuge, 55-57 DEG C
Lower dry 2.5-3.5 hours, obtain beet alkali citrates.
In addition, beet alkali citrates can also be using the product for including the following steps to be prepared：
Monoxone is added in the there-necked flask equipped with return duct, after distillation water dissolution, in three times by sodium bicarbonate solid
It is added, it is 6.5-7 to be neutralized to pH, is slowly added to 30% trimethylamine aqueous solution under stirring, is reacted 2-3 hours at 25-35 DEG C,
Heating water bath reacts 3-3.5 hours to 55-60 DEG C, is again heated to 90 DEG C and reacts 1.5 hours, cooling obtains reaction solution；
Storng-acid cation exchange resin is fitted into exchange column, after distilling water wash to neutrality, so that resin is turned with hydrochloric acid
Become H+ types, by reaction solution with the speed of 1.5L/h by resin, is eluted afterwards to pH as 7 with the rate of 2L/h with purified water, then
The ammonium hydroxide for being 4% with mass fraction is eluted with the rate of 0.8L/h, collects the eluent containing glycine betaine,
Citric Acid Mono is added in eluent, is stirred 5 hours at room temperature, until pH value of solution is that vacuum is dense at 2.5,80 DEG C
It is reduced to the 1/3 of original volume, crystallizes 8 hours at room temperature, obtains white crystal, is centrifuged, it is 2 hours dry at 60 DEG C, obtain glycine betaine
Citrate.
A kind of bait, including the raw material of following parts by weight are prepared：
0.2-0.5 parts of renovation agent as described above；
20-30 parts of dried silkworm chrysalis meal；
0.5-0.8 parts of egg-shell meal；
10-15 parts of soybean cake dregs；
3-8 parts of wheatfeed；
2-5 parts of cereal vinasse；
0.5-0.9 parts of soybean oil；
5-8 parts of spirulina powder；
9-15 parts of alginic acid.
In the present invention, as an improvement, the bait is prepared using the method included the following steps：
S1, dried silkworm chrysalis meal, soybean cake dregs, wheatfeed, cereal vinasse are crushed to 60 mesh powder, then carry out expansion pretreatment；
S2, by the pretreated crushing materials of step S1 to 100-120 mesh；
Egg-shell meal, spirulina powder are added under the conditions of S3, the material stirring for obtaining step S2, water, protease is then added
And amylase, adjustment pH is 6.0, and constant temperature is handled for 3 hours at 36-38 DEG C；
S4, the material for obtaining step S3 adjust pH value to neutrality, soybean oil then are added, alginic acid stirs evenly, then
Renovation agent is added；
S5, the crushing material for obtaining step S4 to granularity are 1-5 μm, and spray drying is then carried out at 75-80 DEG C and is made
Grain, obtains bait.
The bait that the present invention obtains, feeds, and to having there is illness, two times a day, is used in conjunction 5 days.When preventing illness, often
It is primary.
It is applicable in symptom：Cultivated animals indigestion, intestinal wall erosion, enteritis, diarrhea etc.；The enlargement of cultivated animals liver and gall, fat
Liver, hepatonecrosis, ascites etc..
After using above-mentioned technical proposal, the beneficial effects of the invention are as follows：
This renovation agent can restore liver function, repair liver sausage cell, detoxication and toxicant eliminating function, reduce fat, and accelerate various in liver
The speed of production of enzyme rebuilds intestinal beneficial flora；Cellular energy is provided, to restoring enteron aisle liver function rapidly, improves resisting stress
Ability has obvious effect.
Specific implementation mode
With reference to specific embodiment, the present invention is further described.But the purposes and mesh of these exemplary embodiments
Be only used for enumerating the present invention, any type of any restriction not is constituted to the real protection scope of the present invention, it is more non-to incite somebody to action this
The protection domain of invention is confined to this.
Embodiment 1
A kind of efficient liver, intestinal regeneration agent, include the raw material of following parts by weight：40 parts of glycine betaine；Tributyrin 5
Part；It is electrolysed 8 parts of multidimensional；20 parts of starch；8 parts of silica.In the present embodiment, the glycine betaine and its derivative use fine sweet tea
Dish alkali.Fine glycine betaine is the product obtained using the preparation method included the following steps：By the mother liquor heating after beet sugar manufacture
To 55 DEG C, it is added with stirring calcium chloride at 120 revs/min, is filtered while hot, hydrochloric acid to filtrate muddiness is added in filtrate and no longer produces
It is raw, it is then crystallized at 20 DEG C, detaches, dries, obtain crude product glycine betaine；Crude product is dissolved into water and obtains feed liquid, by feed liquid
It is added to the fresh water compartment of electric drive membrane separator, and inwardly adds deionized water, until conductivity is 50000us/cm, to concentrated water
Deionized water is added in compartment, opens electric drive membrane separator, until the conductivity of feed liquid is 2500us/cm, obtains fine feed liquid；
The fine feed liquid is handled using electrodialysis apparatus：Fine feed liquid, the configuration of pole water are added in fresh water compartment, concentrated water compartment
The sodium chloride solution of 10000us/cm, operating flux 500L/h, holding voltage are 40.3V, electric current 2.9A, circular treatment
120-150 minutes, what is obtained in fresh water compartment was fine alkali solution of beet, by the vacuum distillation of fine alkali solution of beet, crystallization,
Obtain fine glycine betaine.
Embodiment 2
A kind of efficient liver, intestinal regeneration agent, include the raw material of following parts by weight：50 parts of beet alkali hydrochlorate；Three butyric acid
8 parts of glyceride；It is electrolysed 10 parts of multidimensional；30 parts of starch；0 part of silica 1.The beet alkali hydrochlorate is using including following step
Suddenly the product being prepared：The fine alkali solution of beet obtained using embodiment 1, is added dropwise concentrated hydrochloric acid under stiring, until occurring
Until emulsion no longer disappears, is placed 24 hours at 50 DEG C, be cooled to 30 DEG C, until beet alkali hydrochlorate crystallization is precipitated, filtering, Gu
Body is washed twice with the ethanol solution that mass fraction is 50%, obtains beet alkali hydrochlorate.
Embodiment 3
A kind of efficient liver, intestinal regeneration agent, the renovation agent includes the raw material of following parts by weight：48 parts of glycine betaine；Three
8 parts of glycerol monobutyralte；It is electrolysed 10 parts of multidimensional；27 parts of starch；9 parts of silica.In the present embodiment, the glycine betaine and its derivative
Object uses fine glycine betaine.Fine glycine betaine is the product obtained using the preparation method included the following steps：By beet sugar manufacture
Mother liquor afterwards is heated to 65 DEG C, is added with stirring calcium chloride at 125 revs/min, filters while hot, and hydrochloric acid is added in filtrate to filter
Liquid muddiness no longer generates, and is then crystallized at 25 DEG C, detaches, dries, and obtains crude product glycine betaine；Crude product is dissolved into water and is obtained
Feed liquid is added to the fresh water compartment of electric drive membrane separator feed liquid, and inwardly adds deionized water, until conductivity is
Deionized water is added into concentrated water compartment by 50000us/cm, electric drive membrane separator is opened, until the conductivity of feed liquid is
2500us/cm obtains fine feed liquid；The fine feed liquid is handled using electrodialysis apparatus：In fresh water compartment, concentrated water compartment
Fine feed liquid is added, pole water configures the sodium chloride solution of 10000us/cm, operating flux 500L/h, and holding voltage is
40.3V, electric current 2.9A, circular treatment 135 minutes, what is obtained in fresh water compartment is fine alkali solution of beet, by fine sweet tea
The vacuum distillation of dish aqueous slkali, crystallization, obtain fine glycine betaine.
Embodiment 4
A kind of efficient liver, intestinal regeneration agent, the renovation agent includes the raw material of following parts by weight：Beet alkali hydrochlorate 42
Part；6 parts of tributyrin；It is electrolysed 9 parts of multidimensional；22 parts of starch；8 parts of silica.In the present embodiment, beet alkali hydrochlorate is also
Can be using the product for including the following steps to be prepared：Chlorine is added in the three-necked flask equipped with stirring, reflux condenser
Acetic acid and n,N-Dimethylformamide, stirring make monoxone be completely dissolved, and 33% front three aqueous amine is added in single-necked flask
Solution heats trimethylamine aqueous solution, with condenser pipe cooling gas, and gas is slowly introducing by drying device and fills monoxone
In the flask of solution, control temperature is no more than 20 DEG C when ventilation, exports residual air by reflux condenser upper end rubber tube and recycles,
It is warming up to 60 DEG C, isothermal reaction 5h after ventilation, after reaction, filters, vacuum drying obtains white powdery solids；
Ethyl alcohol is added in single port bottle, adds above-mentioned white powdery solids, stirring and dissolving, vacuum distillation obtain beet alkali hydrochlorate.
Embodiment 5
A kind of efficient liver, intestinal regeneration agent, include the raw material of following parts by weight：40 parts of beet alkali hydrochlorate；Three butyric acid
8 parts of glyceride；It is electrolysed 8 parts of multidimensional；30 parts of starch；9 parts of silica.The beet alkali hydrochlorate is to use to include the following steps
The product being prepared：The fine alkali solution of beet obtained using 1 method of embodiment, is added dropwise concentrated hydrochloric acid under stiring, until going out
Until existing emulsion no longer disappears, is placed 36 hours at 60 DEG C, be cooled to 35 DEG C, until beet alkali hydrochlorate crystallization is precipitated, filtering,
Solid is washed twice with the ethanol solution that mass fraction is 50%, obtains beet alkali hydrochlorate.
Embodiment 6
A kind of efficient liver, intestinal regeneration agent, the renovation agent includes the raw material of following parts by weight：Fine glycine betaine 45
Part；7 parts of tributyrin；It is electrolysed 10 parts of multidimensional；25 parts of starch；8 parts of silica.In the present embodiment, the glycine betaine and
Its derivative uses fine glycine betaine.Fine glycine betaine is the product obtained using the preparation method included the following steps：By sweet tea
Mother liquor after dish sugaring is heated to 60 DEG C, is added with stirring calcium chloride at 135 revs/min, filters while hot, salt is added in filtrate
Acid to filtrate muddiness no longer generates, and is then crystallized at 25 DEG C, detaches, dries, and obtains crude product glycine betaine；Crude product is dissolved into water
In obtain feed liquid, feed liquid is added to the fresh water compartment of electric drive membrane separator, and inwardly plus deionized water, until conductivity is
Deionized water is added into concentrated water compartment by 50000us/cm, electric drive membrane separator is opened, until the conductivity of feed liquid is
2500us/cm obtains fine feed liquid；The fine feed liquid is handled using electrodialysis apparatus：In fresh water compartment, concentrated water compartment
Fine feed liquid is added, pole water configures the sodium chloride solution of 10000us/cm, operating flux 500L/h, and holding voltage is
40.3V, electric current 2.9A, circular treatment 135 minutes, what is obtained in fresh water compartment is fine alkali solution of beet, by fine sweet tea
The vacuum distillation of dish aqueous slkali, crystallization, obtain fine glycine betaine.
Embodiment 7
A kind of efficient liver, intestinal regeneration agent, the renovation agent includes the raw material of following parts by weight：Betaine phosphate 42
Part；8 parts of tributyrin；It is electrolysed 9 parts of multidimensional；27 parts of starch；8 parts of silica.In the present embodiment, betaine phosphate is
Using the product for including the following steps to be prepared：Monoxone is made into 30% aqueous solution, is placed in reactor, starts and stirs
It mixes, being neutralized to pH4.5 with 20% sodium hydrate aqueous solution or sodium carbonate is made sodium chloroacetate solution；20 DEG C are subsequently cooled to,
The trimethylamine aqueous solution of addition 30% is passed through front three amine gas, and the molar ratio of sodium chloroacetate and trimethylamine is 1: 1.20, control
Temperature is reacted 6 hours at 45 DEG C；Multiply heat filtering after reaction solution concentration and removes sodium chloride, it is cold with 45% phosphoric acid tune pH to 2.0
But crystallization filtering, obtains betaine phosphate.
Embodiment 8
A kind of efficient liver, intestinal regeneration agent, the renovation agent includes the raw material of following parts by weight：Beet alkali citrates
48 parts；6 parts of tributyrin；It is electrolysed 9.5 parts of multidimensional；23 parts of starch；8.5 parts of silica.In the present embodiment, glycine betaine lemon
Lemon hydrochlorate is using the product for including the following steps to be prepared：Citric Acid Mono is added to fine sweet tea prepared by embodiment 1
It in dish aqueous slkali, stirs 4 hours at room temperature, until pH value of solution is to be concentrated in vacuo at 1/3,25 DEG C of original volume to crystallize at 3,83 DEG C
6 hours, white crystal is obtained, is centrifuged, it is 2.5 hours dry at 55 DEG C, obtain beet alkali citrates.
Embodiment 9
A kind of efficient liver, intestinal regeneration agent, the renovation agent includes the raw material of following parts by weight：Beet alkali citrates
46 parts；7 parts of tributyrin；It is electrolysed 9 parts of multidimensional；23 parts of starch；8 parts of silica.In the present embodiment, glycine betaine citric acid
Salt is using the product for including the following steps to be prepared：Monoxone is added in the there-necked flask equipped with return duct, distilled water is used
After dissolving, sodium bicarbonate solid is added in three times, it is 6.5 to be neutralized to pH, under stirring that 30% trimethylamine aqueous solution is slow
It is added, is reacted 2.5 hours at 30 DEG C, heating water bath reacts 3.2 hours to 58 DEG C, is again heated to 90 DEG C and reacts 1.5 hours, cold
But reaction solution is obtained；Storng-acid cation exchange resin is fitted into exchange column, after distilling water wash to neutrality, makes tree with hydrochloric acid
Fat is transformed into H+ types, by reaction solution with the speed of 1.5L/h by resin, is eluted afterwards to pH with the rate of 2L/h with purified water and is
7, then eluted with the rate of 0.8L/h with the ammonium hydroxide that mass fraction is 4%, the eluent containing glycine betaine is collected, by a water lemon
Acid is added in eluent, is stirred 5 hours at room temperature, until pH value of solution is to be concentrated in vacuo to the 1/3 of original volume at 2.5,80 DEG C, room
The lower crystallization of temperature 8 hours, obtains white crystal, centrifuges, 2 hours dry at 60 DEG C, obtains beet alkali citrates.
Embodiment 10
A kind of bait, including the raw material of following parts by weight are prepared：0.2 part of renovation agent prepared by embodiment 6；Dried silkworm chrysalis meal
20 parts；0.5 part of egg-shell meal；10 parts of soybean cake dregs；3 parts of wheatfeed；2 parts of cereal vinasse；0.5 part of soybean oil；5 parts of spirulina powder；
9 parts of alginic acid.
It is prepared using the method included the following steps：
S1, dried silkworm chrysalis meal, soybean cake dregs, wheatfeed, cereal vinasse are crushed to 60 mesh powder, then carry out expansion pretreatment；
S2, by the pretreated crushing materials of step S1 to 100 mesh；
Egg-shell meal, spirulina powder are added under the conditions of S3, the material stirring for obtaining step S2, water, protease is then added
And amylase, adjustment pH is 6.0, and constant temperature is handled for 3 hours at 36 DEG C；
S4, the material for obtaining step S3 adjust pH value to neutrality, soybean oil then are added, alginic acid stirs evenly, then
Renovation agent is added；
S5, the crushing material for obtaining step S4 to granularity are 1 μm, and spray drying granulation is then carried out at 75 DEG C, is obtained
To bait.
Embodiment 11
A kind of bait, including the raw material of following parts by weight are prepared：
0.5 part of renovation agent prepared by embodiment 6；30 parts of dried silkworm chrysalis meal；0.8 part of egg-shell meal；15 parts of soybean cake dregs；Wheatfeed 8
Part；5 parts of cereal vinasse；0.9 part of soybean oil；8 parts of spirulina powder；15 parts of alginic acid.
It is prepared using the method included the following steps：
S1, dried silkworm chrysalis meal, soybean cake dregs, wheatfeed, cereal vinasse are crushed to 60 mesh powder, then carry out expansion pretreatment；
S2, by the pretreated crushing materials of step S1 to 120 mesh；
Egg-shell meal, spirulina powder are added under the conditions of S3, the material stirring for obtaining step S2, water, protease is then added
And amylase, adjustment pH is 6.0, and constant temperature is handled for 3 hours at 38 DEG C；
S4, the material for obtaining step S3 adjust pH value to neutrality, soybean oil then are added, alginic acid stirs evenly, then
Renovation agent is added；
S5, the crushing material for obtaining step S4 to granularity are 5 μm, and spray drying granulation is then carried out at 80 DEG C, is obtained
To bait.
Embodiment 12
A kind of bait, including the raw material of following parts by weight are prepared：
0.4 part of renovation agent prepared by embodiment 6；25 parts of dried silkworm chrysalis meal；0.6 part of egg-shell meal；12 parts of soybean cake dregs；Wheatfeed 5
Part；4 parts of cereal vinasse；0.7 part of soybean oil；6 parts of spirulina powder；12 parts of alginic acid.
It is prepared using the method included the following steps：
S1, dried silkworm chrysalis meal, soybean cake dregs, wheatfeed, cereal vinasse are crushed to 60 mesh powder, then carry out expansion pretreatment；
S2, by the pretreated crushing materials of step S1 to 110 mesh；
Egg-shell meal, spirulina powder are added under the conditions of S3, the material stirring for obtaining step S2, water, protease is then added
And amylase, adjustment pH is 6.0, and constant temperature is handled for 3 hours at 37 DEG C；
S4, the material for obtaining step S3 adjust pH value to neutrality, soybean oil then are added, alginic acid stirs evenly, then
Renovation agent is added；
S5, the crushing material for obtaining step S4 to granularity are 3 μm, and spray drying granulation is then carried out at 77 DEG C, is obtained
To bait.
Embodiment 13
The bait of the present embodiment uses renovation agent prepared by embodiment 1, remaining component and preparation method with embodiment 12
It is identical.
Embodiment 14
The bait of the present embodiment uses renovation agent prepared by embodiment 2, remaining component and preparation method with embodiment 12
It is identical.
Embodiment 15
The bait of the present embodiment uses renovation agent prepared by embodiment 3, remaining component and preparation method with embodiment 12
It is identical.
Embodiment 16
The bait of the present embodiment uses renovation agent prepared by embodiment 4, remaining component and preparation method with embodiment 12
It is identical.
Embodiment 17
The bait of the present embodiment uses renovation agent prepared by embodiment 5, remaining component and preparation method with embodiment 12
It is identical.
Embodiment 16
The bait of the present embodiment uses renovation agent prepared by embodiment 7, remaining component and preparation method with embodiment 12
It is identical.
Embodiment 17
The bait of the present embodiment uses renovation agent prepared by embodiment 8, remaining component and preparation method with embodiment 12
It is identical.
Embodiment 18
The bait of the present embodiment uses renovation agent prepared by embodiment 9, remaining component and preparation method with embodiment 12
It is identical.
Comparative example 1
Application No. is 201410092186.8 patent, phagostimulant contains in parts by weight at being grouped as：Glycine betaine 30
~40 parts by weight, 15~25 parts by weight of trimethylamine oxide, 15~20 parts by weight of dimethyl-β-thiopropionate, allicin 20~30
Parts by weight.
Comparative example 2
Application No. is 201310664980.0 patents, nutrition fish-prawn-crab feed formula, and interior every part of feed includes following original
Material formula：Fish meal 25-30g, dregs of beans 20-23g, peanut meal 10g, shrimp shell meal 5g, oyster shell whiting 1g, cotton dregs 3g, meat meal tankage 2g, dried noodle
16-18g, yeast powder 2-3g, fish oil 1g, skin chaff 3-4g, premix 1g, choline 0.1g, natural glycine betaine 0.2g, phosphonic acids potassium dihydrogen
1.8-2g, seawood meal 0-0.2g, shelling element 0.1g, garlic 0.05g, lactic acid gemma 0.2g, producing enzyme probiotic 0.2g, adhesive
0.3g, salt 0.2g.
Comparative example 3
Commercially available fish meal bait.
Comparative example 4
Commercially available fish meal bait, every kilogram of mixing have renovation agent prepared by 0.6kg embodiments 6.
Illness prevents to use embodiment
Same shrimp-cultivation pool is selected, five independent culturing areas are divided into.
By five shrimp-cultivation pools at random marked as ABCDE, and equivalent feeds embodiment 12, comparative example 1, comparison in fact respectively
Apply bait prepared by example 2, comparative example 3, comparative example 4.
Once a day.Remaining time feeds the commercially available fish meal bait of equivalent.
It is cultivated 10 days with same condition, observes the situation of fishes and shrimps, daily salvaged dead fishes and shrimps, and record dead disease
Shape, as a result such as following table.
| Group | The dead quantity (only) | Liver and gall lesion (%) | Intestinal tract injury (%) |
| A | 124 | 5.7 | 3.9 |
| B | 159 | 9.7 | 8.1 |
| C | 157 | 9.4 | 7.5 |
| D | 179 | 15.6 | 17.4 |
| E | 132 | 5.9 | 4.2 |
By result above it can be found that using bait provided by the invention and being mixed with present invention offer renovation agent
Commercially available common bait can slightly reduce the mortality of fishes and shrimps, it is particularly possible to substantially reduce because of " liver and gall lesion, enteron aisle damage
It is dead caused by wound ".
It proves：Renovation agent provided by the invention, bait for prevent fishes and shrimps " liver and gall lesion, intestinal tract injury " have it is apparent
Effect.
Treatment for diseases uses embodiment
A fishes and shrimps are selected large area " liver and gall lesion, intestinal epithelial mucosal cell damage and intestinal villus fall off " disease occur
The shrimp-cultivation pool of shape is divided into five independent culturing areas.
By five shrimp-cultivation pools at random marked as ABCDE, and equivalent feeds embodiment 12, comparative example 1, comparison in fact respectively
Apply bait prepared by example 2, comparative example 3, comparative example 4.
Two times a day, it is used in conjunction 5 days.Remaining time feeds the commercially available fish meal bait of equivalent.
It then proceedes to feed the commercially available fish meal bait of equivalent, other conditions cultivate 5 days under the same conditions, observe fishes and shrimps
Dead fishes and shrimps are salvaged, and record dead symptom by situation daily, as a result such as following table.
| Group | The dead quantity (only) | Liver and gall lesion (%) | Intestinal tract injury (%) |
| A | 187 | 25.9 | 57.8 |
| B | 303 | 45.2 | 43.1 |
| C | 286 | 47.1 | 15.7 |
| D | 312 | 42.9 | 46.7 |
| E | 207 | 27.8 | 59.2 |
By result above it can be found that using bait provided by the invention and being mixed with present invention offer renovation agent
Commercially available common bait, for having there is the fish of " liver and gall lesion, intestinal epithelial mucosal cell damage and intestinal villus fall off " symptom
Shrimp can reduce its mortality, can also substantially reduce dead caused by " liver and gall lesion, intestinal tract injury ".
It proves：" liver and gall lesion, intestinal epithelial mucomembranous cell damage for treatment fishes and shrimps for renovation agent provided by the invention, bait
Wound and intestinal villus fall off " it has a significant effect.
It can also be proved using embodiment by two above, comparative example 1, comparative example 2 are for preventing fishes and shrimps
" liver and gall lesion, intestinal epithelial mucosal cell damage and intestinal villus fall off " effect is pretty good, but for having there is " liver and bladder disease
Becoming, intestinal epithelial mucosal cell damage and intestinal villus fall off " the fishes and shrimps effect of symptom is general.
It should be appreciated that the purposes of these embodiments is merely to illustrate the present invention and is not intended to limitation protection model of the invention
It encloses.In addition, it should also be understood that, after reading the technical contents of the present invention, those skilled in the art can make the present invention each
Kind change, modification and/or variation, all these equivalent forms equally fall within and are protected defined by the application the appended claims
Within the scope of shield.
Claims (10)
1. a kind of efficient liver, intestinal regeneration agent, it is characterised in that：Include the raw material of following parts by weight：
40-50 parts of glycine betaine and its derivative；
5-8 parts of tributyrin；
It is electrolysed 8-10 parts of multidimensional；
20-30 parts of starch；
8-10 parts of silica.
2. efficiently liver, intestinal regeneration agent as described in claim 1, it is characterised in that：Include the raw material of following parts by weight：
42-48 parts of glycine betaine and its derivative；
6-8 parts of tributyrin；
It is electrolysed 9-10 parts of multidimensional；
22-27 parts of starch；
8-9 parts of silica.
3. efficiently liver, intestinal regeneration agent as claimed in claim 2, it is characterised in that：Include the raw material of following parts by weight：
45 parts of glycine betaine and its derivative；
7 parts of tributyrin；
It is electrolysed 10 parts of multidimensional；
25 parts of starch；
8 parts of silica.
4. efficient liver as described in any one of claims 1-3, intestinal regeneration agent, it is characterised in that：The glycine betaine and its
Derivative uses fine glycine betaine, and the betanin derivative includes beet alkali hydrochlorate, betaine phosphate, glycine betaine lemon
Hydrochlorate.
5. efficiently liver, intestinal regeneration agent as claimed in claim 4, it is characterised in that：The fine glycine betaine is using packet
Include the product that the preparation method of following steps obtains：
In the autoclave body with stirring, the calcium hydroxide suspension for the 30wt% that addition is made into calcium hydroxide；It is cold to stir water-bath
But under, the aqueous solution for the 20wt% that monoxone is made into is instilled, calcium chloroacetate aqueous solution is obtained；
Calcium chloroacetate aqueous solution is filtered to remove impurity, is imported in the autoclave body that one carries condensing reflux, blender, stirring at normal temperature
Under, the trimethylamine aqueous solution of 30wt% is added dropwise, normal-temperature reaction is warming up to 55 DEG C of reaction 0.8h, then heats up and control after 25 minutes
Temperature processed reacts 1.5h at 80 DEG C, obtains glycine betaine and CaCl2Mixed liquor；
By Ag2CO3Solution is poured into while stirring in the mixed liquor of glycine betaine and calcium chloride, that is, generates white precipitate；Stand three points
Clock filters, and filtrate is the aqueous solution of glycine betaine, is boiled, and concentration (if any Precipitation in concentration process, still needing to filter) is extremely molten
Liquid clear viscous, at 85 DEG C vacuum drying remove minor amount of water, up to fine glycine betaine；
Alternatively, the product obtained using the preparation method included the following steps：
Mother liquor after beet sugar manufacture is heated to 55-65 DEG C, calcium chloride is added with stirring at 120-150 revs/min, while hot mistake
Filter, addition hydrochloric acid to filtrate muddiness no longer generates in filtrate, is then crystallized at 20-30 DEG C, detaches, dries, obtain crude product
Glycine betaine；
Crude product is dissolved into water and obtains feed liquid, feed liquid is added to the fresh water compartment of electric drive membrane separator, and is inwardly added
Deionized water is added into concentrated water compartment until conductivity is 50000us/cm for deionized water, opens electric drive membrane separator, until
The conductivity of feed liquid is 2500us/cm, obtains fine feed liquid；
The fine feed liquid is handled using electrodialysis apparatus：Fine feed liquid, pole water are added in fresh water compartment, concentrated water compartment
The sodium chloride solution of 10000us/cm is configured, operating flux 500L/h, holdings voltage is 40.3V, electric current 2.9A, at cycle
It manages 120-150 minutes, what is obtained in fresh water compartment is fine alkali solution of beet, by the vacuum distillation of fine alkali solution of beet, knot
Crystalline substance obtains fine glycine betaine.
6. efficiently liver, intestinal regeneration agent as claimed in claim 4, it is characterised in that：The beet alkali hydrochlorate is to use
Include the following steps the product being prepared：
Mother liquor after beet sugar manufacture is heated to 55-65 DEG C, calcium chloride is added with stirring at 120-150 revs/min, while hot mistake
Filter, addition hydrochloric acid to filtrate muddiness no longer generates in filtrate, is then crystallized at 20-30 DEG C, detaches, dries, obtain crude product
Glycine betaine；
Crude product is dissolved into water and obtains feed liquid, feed liquid is added to the fresh water compartment of electric drive membrane separator, and is inwardly added
Deionized water is added into concentrated water compartment until conductivity is 50000us/cm for deionized water, opens electric drive membrane separator, until
The conductivity of feed liquid is 2500us/cm, obtains fine feed liquid；
The fine feed liquid is handled using electrodialysis apparatus：Fine feed liquid, pole water are added in fresh water compartment, concentrated water compartment
The sodium chloride solution of 10000us/cm is configured, operating flux 500L/h, holdings voltage is 40.3V, electric current 2.9A, at cycle
It manages 120-150 minutes, what is obtained in fresh water compartment is fine alkali solution of beet；
By fine alkali solution of beet obtained above, concentrated hydrochloric acid is added dropwise under stiring, until there is emulsion and no longer disappearing,
It is placed 24-36 hours at 50-60 DEG C, is cooled to 30-35 DEG C, until beet alkali hydrochlorate crystallization is precipitated, filtering, solid quality point
Number washes twice for 50% ethanol solution, obtains beet alkali hydrochlorate.
7. efficiently liver, intestinal regeneration agent as claimed in claim 4, it is characterised in that：Betaine phosphate is to use to include
The product that following steps are prepared：
It is characterized in that this method is that monoxone is made into the aqueous solution of 20-40%, it is placed in reactor, starts stirring, use 15-
30% sodium hydrate aqueous solution or sodium carbonate is neutralized to pH4.0-5.0 and sodium chloroacetate solution is made；It is subsequently cooled to 10-30
DEG C, the trimethylamine aqueous solution of 25-40% is added or is passed through front three amine gas, the molar ratio of sodium chloroacetate and trimethylamine is 1:
1.00-1.20, control temperature are reacted 5-7 hours at 30-60 DEG C；Multiply heat filtering after reaction solution concentration and remove sodium chloride, uses 30-
85% phosphoric acid tune pH to 2.0-2.5, crystallisation by cooling filtering, obtains betaine phosphate.
8. efficiently liver, intestinal regeneration agent as claimed in claim 4, it is characterised in that：Beet alkali citrates are using packet
Include the product that following steps are prepared：
Mother liquor after beet sugar manufacture is heated to 55-65 DEG C, calcium chloride is added with stirring at 120-150 revs/min, while hot mistake
Filter, addition hydrochloric acid to filtrate muddiness no longer generates in filtrate, is then crystallized at 20-30 DEG C, detaches, dries, obtain crude product
Glycine betaine；
Crude product is dissolved into water and obtains feed liquid, feed liquid is added to the fresh water compartment of electric drive membrane separator, and is inwardly added
Deionized water is added into concentrated water compartment until conductivity is 50000us/cm for deionized water, opens electric drive membrane separator, until
The conductivity of feed liquid is 2500us/cm, obtains fine feed liquid；
The fine feed liquid is handled using electrodialysis apparatus：Fine feed liquid, pole water are added in fresh water compartment, concentrated water compartment
The sodium chloride solution of 10000us/cm is configured, operating flux 500L/h, holdings voltage is 40.3V, electric current 2.9A, at cycle
It manages 120-150 minutes, what is obtained in fresh water compartment is fine alkali solution of beet；
Citric Acid Mono is added in fine alkali solution of beet, is stirred 4-5 hours at room temperature, until pH value of solution is 3-4,83-86
It is concentrated in vacuo at 1/3,25-30 DEG C of original volume and crystallizes 6-7 hours at DEG C, obtain white crystal, centrifuge, done at 55-57 DEG C
It is 2.5-3.5 hours dry, obtain beet alkali citrates.
9. a kind of bait, it is characterised in that：Raw material including following parts by weight is prepared：
0.2-0.5 parts of renovation agent as described in claim 1；
20-30 parts of dried silkworm chrysalis meal；
0.5-0.8 parts of egg-shell meal；
10-15 parts of soybean cake dregs；
3-8 parts of wheatfeed；
2-5 parts of cereal vinasse；
0.5-0.9 parts of soybean oil；
5-8 parts of spirulina powder；
9-15 parts of alginic acid.
10. a kind of bait as claimed in claim 9, it is characterised in that：It is prepared using the method included the following steps：
S1, dried silkworm chrysalis meal, soybean cake dregs, wheatfeed, cereal vinasse are crushed to 60 mesh powder, then carry out expansion pretreatment；
S2, by the pretreated crushing materials of step S1 to 100-120 mesh；
Egg-shell meal, spirulina powder are added under the conditions of S3, the material stirring for obtaining step S2, water, protease and shallow lake is then added
Powder enzyme, adjustment pH is 6.0, and constant temperature is handled for 3 hours at 36-38 DEG C；
S4, the material for obtaining step S3 adjust pH value to neutrality, soybean oil then are added, alginic acid stirs evenly, and add
Renovation agent；
S5, the crushing material for obtaining step S4 to granularity are 1-5 μm, and spray drying granulation is then carried out at 75-80 DEG C, is obtained
To bait.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810415802.7A CN108635369A (en) | 2018-05-03 | 2018-05-03 | A kind of efficient liver, intestinal regeneration agent and bait |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810415802.7A CN108635369A (en) | 2018-05-03 | 2018-05-03 | A kind of efficient liver, intestinal regeneration agent and bait |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108635369A true CN108635369A (en) | 2018-10-12 |
Family
ID=63748794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810415802.7A Pending CN108635369A (en) | 2018-05-03 | 2018-05-03 | A kind of efficient liver, intestinal regeneration agent and bait |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108635369A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111838412A (en) * | 2020-07-10 | 2020-10-30 | 北京和联四海生物科技有限公司 | Anti-stress feed additive for animal breeding and preparation method and application thereof |
| CN113768055A (en) * | 2021-08-11 | 2021-12-10 | 四川省畜牧科学研究院 | Low-emission environment-friendly premix feed for reducing diarrhea rate of piglets, compound feed and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1374293A (en) * | 2002-03-18 | 2002-10-16 | 浙江大学 | Green synthesis process of betaine hydrochloride |
| KR20030084666A (en) * | 2002-04-22 | 2003-11-01 | 조아제약주식회사 | A functional beverage composition |
| CN106721516A (en) * | 2016-11-24 | 2017-05-31 | 佛山市南海东方澳龙制药有限公司 | A kind of aquatic products anti-stress feed and feed addictive |
-
2018
- 2018-05-03 CN CN201810415802.7A patent/CN108635369A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1374293A (en) * | 2002-03-18 | 2002-10-16 | 浙江大学 | Green synthesis process of betaine hydrochloride |
| KR20030084666A (en) * | 2002-04-22 | 2003-11-01 | 조아제약주식회사 | A functional beverage composition |
| CN106721516A (en) * | 2016-11-24 | 2017-05-31 | 佛山市南海东方澳龙制药有限公司 | A kind of aquatic products anti-stress feed and feed addictive |
Non-Patent Citations (2)
| Title |
|---|
| 杨官娥等: "甜菜碱合成新工艺的研究", 《中国药物化学杂志》 * |
| 黄红娜等: "甜菜碱的提取、分离及测定含量方法的研究进展", 《医学综述》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111838412A (en) * | 2020-07-10 | 2020-10-30 | 北京和联四海生物科技有限公司 | Anti-stress feed additive for animal breeding and preparation method and application thereof |
| CN111838412B (en) * | 2020-07-10 | 2023-07-25 | 北京和联四海生物科技有限公司 | Anti-stress feed additive for animal breeding and preparation method and application thereof |
| CN113768055A (en) * | 2021-08-11 | 2021-12-10 | 四川省畜牧科学研究院 | Low-emission environment-friendly premix feed for reducing diarrhea rate of piglets, compound feed and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5759895B2 (en) | Fish feed | |
| CN106343257A (en) | Feed capable of promoting molt of crayfish and preparation method thereof | |
| CN105995183A (en) | Epinephelus coioicles ecological feed formula and preparation method | |
| CN106755228A (en) | The technique for preparing the oligomeric Gly-His-Lys of selenium yeast using Se-enriched yeast | |
| CN107439844A (en) | A kind of Penaeus Vannmei special swelling feed | |
| CN108635369A (en) | A kind of efficient liver, intestinal regeneration agent and bait | |
| US6299928B1 (en) | Fine granular feeds for fry | |
| CN105249019A (en) | Young shrimp feed and preparation method thereof | |
| CN103583918B (en) | Formula and production method of puffed feed for speckled trouts | |
| CN106376723A (en) | Special feed for breeding broiler chickens | |
| WO2014183508A1 (en) | Biogas residue-containing formula feed for chicken | |
| WO2019100540A1 (en) | Method for preparing litopenaeusvannamei feed additive | |
| CN103156186B (en) | Calcium tablet using deep-sea fish bone as raw material and preparation method thereof | |
| CN109496981B (en) | Method for improving egg laying quality of laying hens | |
| CN103349151A (en) | Method for extracting polypeptide protein power from mucous membrane of small intestine of pig | |
| CN102907565A (en) | Production method of aquatic animal feed attractant shrimp paste | |
| CN108354183B (en) | Method for preparing high-quality marine-source amino acid compound calcium powder | |
| CN108991292A (en) | Enhanced water resistance aquatic biological resisting stress food calling additive and preparation method | |
| CN106509491A (en) | Compound feed for scophthalmus maximus and preparation method thereof | |
| CN109349458B (en) | Chinese herbal medicine health-care additive for protecting liver and pancreas of crayfish and preparation method thereof | |
| CN106819398A (en) | The animal feed prepared using glutamic acid fermentation waste material | |
| CN105995177A (en) | Feed for poultry in laying period and preparation method thereof | |
| CN106343229A (en) | Chicken feed | |
| CN105104864A (en) | Antiviral chicken feed and preparation method thereof | |
| CN111821272A (en) | Compound amino acid enteric-coated tablet for dogs and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181012 |
|
| RJ01 | Rejection of invention patent application after publication |