CN108635306A - A kind of anti-wrinkle composition and its preparation for external application to skin and application - Google Patents
A kind of anti-wrinkle composition and its preparation for external application to skin and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a kind of anti-wrinkle composition, the anti-wrinkle composition includes the component of following parts by weight：15 parts of deep-sea fish collagen peptide, 1 10 parts of cockscomb flower extract, 1 10 parts of sharp leaf cortex fraxini extract, 1 10 parts of Epimedium extract, 14 parts of folic acid.Anti-wrinkle composition disclosed in this invention, by the way that deep-sea fish collagen peptide, cockscomb flower extract, sharp leaf cortex fraxini extract, Epimedium extract and folic acid are combined, with good anti-wrinkle synergy, the deep enough deep layer skin of energy, hence it is evident that promote cell metabolism, supplement skin moisture, improve skin elasticity, skin wrinkle is removed, skin is enabled to compact exquisiteness, reduces wrinkle.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of anti-wrinkle composition and its preparation for external application to skin and application.
Background technology
Wrinkle refers to skin to be influenced by external environment, forms the free radical that dissociates, and free radical destroys normal cell membrane tissue
Interior collagen, active material, oxidative cell and the small microgroove, the wrinkle that are formed.Women is 20 years old to be boundary line, collagen in skin
Protein content can gradually decrease, to a series of skin problem occur.The fibrous fracture of corium, fat can be caused to wither simultaneously
Contracting, sweat gland and smegma are reduced, and skin is made a series of aging phenomena such as color spot, slack and undisciplined, wrinkle occur.Skin wrinkle resisting science
Family points out：Canthus is likely to occur shallow small wrinkle, pouch etc. within 25 years old or so；Forehead wrinkle intensification in 30 years old or so increases, the tail of the eye goes out
There is different degrees of wrinkle in lower eyelid skin on existing crow's feet；Then there is nasolabial groove intensification within 40 years old, fine wrinkles occurs in bicker, neck
Wrinkle also and then displays；50 years old then pouch deepen and occur lower eyelid line, also there is wrinkle in upperlip；The then full face by 60 years old
Elastic force declines face wrinkle and deepens.It, under the effect of gravity, can gradual sagging, office due to the relaxation of skin, muscle after 40 years old
Portion folds, and forms gravitation wrinkle.Common such as pouch, senile Blepharochalasis temporal, augnathus.Eyelid position：It is common
At outside upper eyelid 1/3.Due to gravity relationship, can occur under skin with the gradual relaxation of eyelid and skin orbicularis in upper eyelid
It hangs down, lower eyelid sometimes also can be gradually sagging, while can also be gone out from diaphragm hernia due to Orbital septum fat and form " upper eyelid ".Face：It is such
Wrinkle mostly occurs in face lower part, and since the fat of fat pad under eyelid is reduced, eyelid skin of cheek becomes loose, to wrinkle occur.
Jaw portion：Such wrinkle mostly occurs in jaw lower part, and since subcutaneous fat is reduced, lower jaw cutis laxa forms " hang down jaw ".Neck：Neck
The orthostatic wrinkle in portion was happened at after the middle age, since the gradual atrophy of subcutaneous tissue is reduced, cutis laxa, and gravity and
Intensification is added, especially in throat portion, often can form two sagging wrinkles of skin by edge in the neck of both sides platysma.
With the development of the society, expanding economy.The pressure of people is increasing.It is often depressed, it is irritable, it is lonely
It is out-of-the-way, distress, anxiety, overcautious expression usually are shown in face, this expression affects mimetic muscle and generates vertical or horizontal
Wrinkle makes one to gradually appear aging phenomenon.People often have not enough sleep, and the regulatory function of skin can be made impaired, cause appearance thin and pallid
It is worried, it is easy aging corrugation.The excessive exposure due to working, can cause skin injury, make the skin of face, neck, hand
Skin is dried, is thinning, following the string, and elastic fibers and gtelatinous fibre is made to lose normal function, and skin gradually fluffs corrugation.If
Nutritional condition of body is good, and the nutrition supply of skin is sufficient, and subcutaneous tissue is plentiful, the evening that wrinkle occurs as soon as；If nutrition condition is bad,
Cause integumentary musculature histotrophic nutrition bad, cause pachylosis and relaxation, is easy the main wrinkle of production.People are in order to pursue beauty, greatly
Amount uses cosmetics, and the quality of skin can be destroyed using unsuitable cosmetics, and it is thin that excessive face powder can also be such that face occurs
Close rugula.Meanwhile excessively smoke for a long time, the aging of skin can be accelerated, to generating wrinkle too early by drinking, make one to present a weathered appearance
It is wan and sallow.
Since smoothing wrinkle technology develops, there is the rhytidectomy formula of three generations's standard.First generation rhytidectomy moves under water point subcutaneous
From then excision excess skin, tension suture.That said here it is people draws skin art, it has said operation vividly
Key points for operation.Cosmetic plastic surgery circle of developed country has abandoned first generation rhytidectomy already, because only tensioning the skin is inadequate
, it can be restored after maintaining a period of time.Our country's development rhytidectomies are later, develop also uneven street, so still there is part single
Position and individual physician lift art using simple skin.Second generation facial rhytidectomy, referred to as SMAS- platysmas technology detach skin
Valve, after lifting SMAS- neck width muscle flaps upwards, then tensioning the skin valve backward.Third generation rhytidectomy is referred to as compound rhytidectomy.
The method of these wrinkle reductions has that operation wound is big, disadvantage complicated for operation.It is specific as follows：
Cicatricial baldness
Rhytidectomy notch generally can all select in hair zones, with hidden incision.But skin is excessively lifted during surgery, it cuts
Except scalp amount is excessive, notch overtension can be caused after suture, this itself will result in wide scar after healing, form baldness
Area.Furthermore overtension can cause local blood circulation disorder, be easy to form the infection of part, can aggravate scar in this way,
Widen baldness area.Cicatricial baldness once being formed after only waiting for 3-6 months, waits for that scar softens, is cut off.
Facial asymmetry
This is entirely due to doctor is lacked experience and lacked caused by beauty and shaping professional training.It is inaccurate due to pinpointing, in art
The suspention height of tissue and the amount of cutting of skin differ, and cause body surface organ site height different and skin elasticity difference, example
Such as, eyebrow is one high and one low；Canthus is one on the other；Ear-lobe is not in one plane etc..Such case is formed, it also have to hand again
Art is corrected.
The damage of facial nerve
This is the complication of rhytidectomy most serious.It is relatively difficult that violent variation, which causes the reparation of facial nerve injury, passes through god
Through coincideing, can treat, but effect is not satisfied.
Sensory disturbance
Face rhytidectomy will extensively be removed in facial subcutaneous, and the shallow sensory nerve of table will be destroyed, the paralysis of feeling and
Abnormal sensory will be following.
Expression is unnatural
Rhytidectomy causes the separation of skin and expression muscle due to there is extensive subcutaneous stripping.It is postoperative with expression muscle again
During healing, groups of people can cause the unnatural of expression, and often expression is dull, such as " glass " face, there is person
It is very for the face of " indigestion ", especially lower face smoothing wrinkle.
Also the possibility that many complication occur such as form just like hemotoncus, infection, facial scar after rhytidectomy.
Invention content
The present invention is to propose a kind of safe, at low cost, hurtless measure to solve the above-mentioned deficiency present in the prior art,
And the anti-wrinkle composition of wrinkle can be effectively removed, and using the anti-wrinkle composition prepare preparation for external application to skin and this dispel
Purposes of the wrinkle composition in preparing anti-wrinkle external use skin care.
Technical solution of the invention is as follows：
A kind of anti-wrinkle composition, includes the component of following parts by weight：1-5 parts of deep-sea fish collagen peptide, cockscomb（CELOSIA
CRISTATA）1-10 parts of flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）1-10 parts of extract, Epimedium
（EPIMEDIUM SAGITTATUM）1-10 parts of extract, 1-4 parts of folic acid.
The deep-sea fish collagen peptide is commercially available cosmetics-stage commodity, preferably 200~500 dalton of molecular weight.
Deep-sea fish collagen peptide is by deep-sea fish skin by a kind of enzymolysis micromolecular collagen polypeptide obtained, molecular weight section is low,
Balanced proportion, transdermal rate are high, and can pass through skin surface enhances skin collagen regeneration, restore elasticity of skin, and high water solubility,
Promote the compatibility with other components containing largely exposed hydrogen bond group, keeps stable system.
The cockscomb（CELOSIA CRISTATA）Flower extract extracts from Amaranthaceae feather cockscomb platymiscium cockscomb, contains
It is Kaempferitrin to have abundant nutriment, such as amino acid, trace element and native enzyme, main chemical compositions
（kaempoferitrin）, amaranth glucoside（amaranthin）, pine camphor（pinitol ）And volume potassium nitrate.With good anti-
Oxidation activity contributes to delay skin aging, reduces wrinkle of skin, and have good moist moisture-keeping efficacy, is conducive to improve
Skin elasticity.It can be used as antioxidant, skin-whitening agents, moisturizer etc..
The sharp leaf bark of ash（FRAXINUS SZABOANA）Extract extracts from the dry of Oleaceae plants point leaf Chinese ash
Dry branch skin or dry hide have the function of heat-clearing and damp-drying drug, inducing astrigency, improving eyesight, for hot dysentery, diarrhea, leukorrhea with reddish discharge, red eye, swell pain, mesh
Raw screen film etc..There are antibacterial, anti-inflammatory, calm, antibechic, eliminating the phlegm and antiasthmatic effect.There is compacting effect to loose skin and can be effective
Inhibit skin to itch, can be used as the use of skin natural antibacterial agent.
The Epimedium (Epimediumsagittatum) belongs to Berberidaceae Epimedium herbaceos perennial.
《Chinese Plants will》Record the effect of it has smart strong, the wind-damp dispelling of benefit, controls the diseases such as impotence, articular rheumatic pain.Herba Epimedii
(Herbaepimedii) it is a kind of traditional traditional tonic medicine.Nature and flavor are pungent, sweet, warm, return liver and kidney channel, have kidney-replenishing, strengthening the bones and muscles,
The function of wind-damp dispelling.Chemical composition include flavonoids, lignanoids, phenolic glycoside class, alkaloids, chromone class, phenanthrene, anthraquinone, tannin,
Sequiterpene, sterol etc..With the sharp leaf bark of ash（FRAXINUS SZABOANA）Extract compounds, and can smooth fine wrinkles, improves skin
Skin elasticity, improves dermatoglyph degree.
The folic acid is a kind of efficient skin care ingredient, can be had in conjunction with the moisture of up to 5000 times of own wts
Good performance of keeping humidity can promote the generation of natural moisturizing factor NMF in skin keratin, to form protective film, not change
Percutaneous water loss is reduced in the case of sebum secretion, allows skin to be restored back to rehydration tender soft and smooth.And it is newly old to DNA synthesis, cell
The physiology courses such as metabolism have extremely strong facilitation, and DNA chain ruptures can be promoted to recombine, and effectively repair caused by ultraviolet light
Skin injury allows skin recovery smoothly to recapture resilient flexible.
Deep-sea fish collagen peptide, cockscomb（CELOSIA CRISTATA）Flower extract, the sharp leaf bark of ash（FRAXINUS
SZABOANA）Extract, Epimedium（EPIMEDIUM SAGITTATUM）Extract and folic acid combination, have good dispel
Wrinkle synergy, the deep enough deep layer skin of energy, hence it is evident that promotes cell metabolism, supplements skin moisture, improves skin elasticity, go
Except skin wrinkle, enables skin compact exquisiteness, reduce wrinkle.
In wherein some embodiments, the anti-wrinkle composition further includes the Oxyria sinensis Hemsl of 0.1-5 parts by weight（GOODYERA
KWANGTUNGENSIS）Extract.
The Oxyria sinensis Hemsl（GOODYERA KWANGTUNGENSIS）Extract to the collagen of constitutive protein fiber,
The generation of elastin laminin has stimulation, shows its ability for enhancing skin activity, in conjunction with inoxidizability, has good anti-
Decline wrinkle-proof effect.It compounds deep-sea fish collagen peptide, cockscomb（CELOSIA CRISTATA）Flower extract, the sharp leaf bark of ash
（FRAXINUS SZABOANA）Extract, Epimedium（EPIMEDIUM SAGITTATUM）Extract and folic acid, Neng Goujin
One step promotes the anti-wrinkle effect of composition.
The present invention also provides a kind of preparation for external application to skin, the preparation for external application to skin is added by above-mentioned anti-wrinkle composition
Auxiliary material or complementary ingredient in upper cosmetic field are prepared.
Wherein, the additive amount of the anti-wrinkle composition is the 0.1-5wt% of preparation for external application to skin total amount.
In wherein some embodiments, auxiliary material or complementary ingredient in the cosmetic field include moisturizer, thickening
One or more kinds of mixing in agent, skin conditioning agent, preservative, chelating agent.
In wherein some embodiments, auxiliary material or complementary ingredient in the cosmetic field further include deionized water.
In wherein some embodiments, the moisturizer includes Sodium Hyaluronate, butanediol, glycerine, arginine, plant steroid
Alcohol isostearate, two（Lauramide glutamine）Sodium lysinate, PCA sodium, hydrolysis silk, pungent glycol, 1,2- pentanediols,
One kind or one in sucrose, trehalose, rhamnose, mannose, gossypose, glycine betaine, erythrite, xylitol, biological carbohydrate gum -2
Kind or more mixing.
In wherein some embodiments, the thickener includes xanthans, carbomer, hydroxyethyl cellulose, hydroxypropyl fibre
One or more kinds of mixing in dimension element, hydroxypropyl methyl cellulose.
In wherein some embodiments, the skin conditioning agent includes tocopherol, niacinamide, bisabolol, ascorbic acid
One or more in four different palmitates, pyridoxine dicaprylate, pyridoxine dipalmitate, retinyl palmitate
Mixing.
In wherein some embodiments, the preservative includes Chlorphenesin, Phenoxyethanol, potassium sorbate, sodium benzoate
In one or more kinds of mixing.
In wherein some embodiments, the chelating agent include EDTA disodiums, one kind in tetra- sodium of EDTA or it is a kind of with
On mixing.
External preparation of the present invention is gelling agent, ointment, lotion, surfactant, Essence or facial mask.
According to application of the anti-wrinkle composition as described above in preparing anti-wrinkle external use skin care.
The present invention compared with the existing technology, has the following advantages that：
Anti-wrinkle composition disclosed in this invention, by by deep-sea fish collagen peptide, cockscomb（CELOSIA CRISTATA）
Flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）Extract, Epimedium（EPIMEDIUM SAGITTATUM）It carries
It takes object and folic acid to be combined, there is good anti-wrinkle synergy, the deep enough deep layer skin of energy, hence it is evident that promote cell metabolism,
Skin moisture is supplemented, skin elasticity is improved, removes skin wrinkle, skin is enabled to compact exquisiteness, reduces wrinkle；Cosmetics are being added in it
After common auxiliary material or complementary ingredient in field, preparation for external application to skin is prepared, and this preparation for external application to skin can be bright
The aobvious elasticity for increasing skin makes skin become fine and smooth, to keep the wrinkle formed thin out or disappear, while increasing skin
Water content.The composition and its preparation of the present invention has wrinkle improvement effect apparent, and moisture-keeping function is strong, and the duration is long, is effectively increased
The advantages that skin elasticity, good biocompatibility, safe without toxic side effect.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Embodiment 1
A kind of anti-wrinkle composition, is grouped as by the group of following parts by weight：5 parts of deep-sea fish collagen peptide, cockscomb（CELOSIA
CRISTATA）1 part of flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）10 parts of extract, Epimedium
（EPIMEDIUM SAGITTATUM）1 part of extract, 4 parts of folic acid.
Embodiment 2
A kind of anti-wrinkle composition, is grouped as by the group of following parts by weight：1 part of deep-sea fish collagen peptide, cockscomb（CELOSIA
CRISTATA）10 parts of flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）1 part of extract, Epimedium
（EPIMEDIUM SAGITTATUM）10 parts of extract, 1 part of folic acid.
Embodiment 3
A kind of anti-wrinkle composition, is grouped as by the group of following parts by weight：3 parts of deep-sea fish collagen peptide, cockscomb（CELOSIA
CRISTATA）5 parts of flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）5 parts of extract, Epimedium
（EPIMEDIUM SAGITTATUM）5 parts of extract, 2 parts of folic acid.
Embodiment 4
A kind of anti-wrinkle composition, is grouped as by the group of following parts by weight：4 parts of deep-sea fish collagen peptide, cockscomb（CELOSIA
CRISTATA）3 parts of flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）2 parts of extract, Epimedium
（EPIMEDIUM SAGITTATUM）7 parts of extract, 3 parts of folic acid, Oxyria sinensis Hemsl（GOODYERA KWANGTUNGENSIS）Extract
0.1 part.
Embodiment 5
A kind of anti-wrinkle composition, is grouped as by the group of following parts by weight：2 parts of deep-sea fish collagen peptide, cockscomb（CELOSIA
CRISTATA）7 parts of flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）8 parts of extract, Epimedium
（EPIMEDIUM SAGITTATUM）3 parts of extract, 3 parts of folic acid, Oxyria sinensis Hemsl（GOODYERA KWANGTUNGENSIS）Extract
5 parts.
Embodiment 6
A kind of anti-wrinkle composition, is grouped as by the group of following parts by weight：3 parts of deep-sea fish collagen peptide, cockscomb（CELOSIA
CRISTATA）5 parts of flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）5 parts of extract, Epimedium
（EPIMEDIUM SAGITTATUM）5 parts of extract, 2 parts of folic acid, Oxyria sinensis Hemsl（GOODYERA KWANGTUNGENSIS）Extract
3 parts.
Embodiment 7
A kind of anti-wrinkle Essence, includes the component of following mass percentage：1 anti-wrinkle composition 0.1% of embodiment, hyaluronic acid
Sodium 0.05%, EDTA disodiums 0.01%, butanediol 5%, glycerine 1%, xanthans 0.25%, Chlorphenesin 0.01%, carbomer 0.3%,
Arginine 0.1%, phytosterol isostearate 1%, two（Lauramide glutamine）Sodium lysinate 0.1%, tocopherol 0.1%,
PCA sodium 0.1%, Phenoxyethanol 0.5%, niacinamide 0.1%, hydrolysis silk 1%, 1,2- pentanediols 1%, pungent glycol 1%, water surplus.
Embodiment 8
A kind of anti-wrinkle Essence, includes the component of following mass percentage：2 anti-wrinkle composition 5% of embodiment, Sodium Hyaluronate
0.01%, EDTA disodiums 0.05%, butanediol 1%, glycerine 10%, xanthans 0.05%, Chlorphenesin 0.1%, carbomer 0.1%, essence
Propylhomoserin 0.3%, phytosterol isostearate 0.1%, two（Lauramide glutamine）Sodium lysinate 1%, tocopherol 0.01%,
PCA sodium 1%, Phenoxyethanol 0.1%, niacinamide 3%, hydrolysis silk 0.1%, 1,2- pentanediols 3%, pungent glycol 0.1%, water surplus.
Embodiment 9
A kind of anti-wrinkle Essence, includes the component of following mass percentage：3 anti-wrinkle composition 3% of embodiment, Sodium Hyaluronate
0.03%, EDTA disodiums 0.03%, butanediol 3%, glycerine 5%, xanthans 0.1%, Chlorphenesin 0.05%, carbomer 0.2%, smart ammonia
Acid 0.2%, phytosterol isostearate 0.5%, two（Lauramide glutamine）Sodium lysinate 0.5%, tocopherol 0.05%,
PCA sodium 0.5%, Phenoxyethanol 0.3%, niacinamide 2%, hydrolysis silk 0.5%, 1,2- pentanediols 2%, pungent glycol 0.5%, water surplus.
Embodiment 10
A kind of anti-wrinkle Essence, includes the component of following mass percentage：4 anti-wrinkle composition 2% of embodiment, Sodium Hyaluronate
0.02%, EDTA disodiums 0.04%, butanediol 2%, glycerine 8%, xanthans 0.2%, Chlorphenesin 0.08%, carbomer 0.15%, essence
Propylhomoserin 0.15%, phytosterol isostearate 0.3%, two（Lauramide glutamine）Sodium lysinate 0.6%, tocopherol
0.02%, PCA sodium 0.3%, Phenoxyethanol 0.4%, niacinamide 1%, hydrolysis silk 0.8%, 1,2- pentanediols 1.5%, pungent glycol
0.3%, water surplus.
Embodiment 11
A kind of anti-wrinkle Essence, includes the component of following mass percentage：5 anti-wrinkle composition 4% of embodiment, Sodium Hyaluronate
0.04%, EDTA disodiums 0.02%, butanediol 4%, glycerine 2%, xanthans 0.15%, Chlorphenesin 0.03%, carbomer 0.25%, essence
Propylhomoserin 0.25%, phytosterol isostearate 0.6%, two（Lauramide glutamine）Sodium lysinate 0.3%, tocopherol
0.03%, PCA sodium 0.7%, Phenoxyethanol 0.4%, niacinamide 1.5%, hydrolysis silk 0.4%, 1,2- pentanediols 2.5%, pungent glycol
0.4%, water surplus.
Embodiment 12
A kind of anti-wrinkle Essence, includes the component of following mass percentage：6 anti-wrinkle composition 3% of embodiment, Sodium Hyaluronate
0.03%, EDTA disodiums 0.03%, butanediol 3%, glycerine 5%, xanthans 0.1%, Chlorphenesin 0.04%, carbomer 0.2%, smart ammonia
Acid 0.2%, phytosterol isostearate 0.5%, two（Lauramide glutamine）Sodium lysinate 0.5%, tocopherol 0.05%,
PCA sodium 0.5%, Phenoxyethanol 0.3%, niacinamide 2%, hydrolysis silk 0.5%, 1,2- pentanediols 2%, pungent glycol 0.8%, water surplus.
Comparative example 1
A kind of anti-wrinkle Essence, includes the component of following mass percentage：Deep-sea fish collagen peptide 3%, Sodium Hyaluronate
0.03%, EDTA disodiums 0.03%, butanediol 3%, glycerine 5%, xanthans 0.1%, Chlorphenesin 0.05%, carbomer 0.2%, smart ammonia
Acid 0.2%, phytosterol isostearate 0.5%, two（Lauramide glutamine）Sodium lysinate 0.5%, tocopherol 0.05%,
PCA sodium 0.5%, Phenoxyethanol 0.3%, niacinamide 2%, hydrolysis silk 0.5%, 1,2- pentanediols 2%, pungent glycol 0.5%, water surplus.
Comparative example 2
A kind of anti-wrinkle Essence, includes the component of following mass percentage：Cockscomb（CELOSIA CRISTATA）Flower extraction
Object 3%, Sodium Hyaluronate 0.03%, EDTA disodiums 0.03%, butanediol 3%, glycerine 5%, xanthans 0.1%, Chlorphenesin 0.05%,
Carbomer 0.2%, arginine 0.2%, phytosterol isostearate 0.5%, two（Lauramide glutamine）Sodium lysinate
0.5%, tocopherol 0.05%, PCA sodium 0.5%, Phenoxyethanol 0.3%, niacinamide 2%, hydrolysis silk 0.5%, 1,2- pentanediols 2%,
Pungent glycol 0.5%, water surplus.
Comparative example 3
A kind of anti-wrinkle Essence, includes the component of following mass percentage：The sharp leaf bark of ash（FRAXINUS SZABOANA）Extraction
Object 3%, Sodium Hyaluronate 0.03%, EDTA disodiums 0.03%, butanediol 3%, glycerine 5%, xanthans 0.1%, Chlorphenesin 0.05%,
Carbomer 0.2%, arginine 0.2%, phytosterol isostearate 0.5%, two（Lauramide glutamine）Sodium lysinate
0.5%, tocopherol 0.05%, PCA sodium 0.5%, Phenoxyethanol 0.3%, niacinamide 2%, hydrolysis silk 0.5%, 1,2- pentanediols 2%,
Pungent glycol 0.5%, water surplus.
Comparative example 4
A kind of anti-wrinkle Essence, includes the component of following mass percentage：Epimedium（EPIMEDIUM
SAGITTATUM）Extract 3%, Sodium Hyaluronate 0.03%, EDTA disodiums 0.03%, butanediol 3%, glycerine 5%, xanthans
0.1%, Chlorphenesin 0.05%, carbomer 0.2%, arginine 0.2%, phytosterol isostearate 0.5%, two（Lauramide paddy
Glutamine）Sodium lysinate 0.5%, tocopherol 0.05%, PCA sodium 0.5%, Phenoxyethanol 0.3%, niacinamide 2%, hydrolysis silk
0.5%, 1,2- pentanediols 2%, pungent glycol 0.5%, water surplus.
Comparative example 5
A kind of anti-wrinkle Essence, includes the component of following mass percentage：Folic acid 3%, Sodium Hyaluronate 0.03%, EDTA bis-
Sodium 0.03%, butanediol 3%, glycerine 5%, xanthans 0.1%, Chlorphenesin 0.05%, carbomer 0.2%, arginine 0.2%, plant steroid
Alcohol isostearate 0.5%, two（Lauramide glutamine）Sodium lysinate 0.5%, tocopherol 0.05%, PCA sodium 0.5%, benzene oxygen
Ethyl alcohol 0.3%, niacinamide 2%, hydrolysis silk 0.5%, 1,2- pentanediols 2%, pungent glycol 0.5%, water surplus.
One anti-wrinkle compliance test result of experimental example
1, sample:
Anti-wrinkle Essence prepared by embodiment 7-12, comparative example 1-5.
2, the selection and grouping of volunteer：
Choosing has the healthy volunteer 550 of the wrinkles such as microgroove, crow's feet, expression line, dry line, neck line, wherein male 200
Name, women 350, the age between 35-61 Sui, average age be 52.1 years old, without serious systemic disease, immune deficiency or
Autoimmune disease, to cosmetics without allergy, facial no acute inflammation, hormone medicine or immunosuppressor is not used, do not join
Add other clinical tests, does not smear external preparation.This 550 volunteers are randomly divided into 11 groups, every group of 50 people.
3, application method：
Sample is spread evenly across at wrinkle, each 1ml, is used continuously 30 days.The impression and skin that it is used are evaluated after 30 days
Texture situation.
Evaluation criterion：Use feeling derives from the feeling of volunteer's readme, and dermatoglyph situation passes through direct visual perception
It is tested with dermatoglyph, as shown in table 1：
Table 1
Experimental result is as shown in table 2：
Table 2
As can be known from the above table, embodiment 7-12 anti-wrinkle Essence is using after 30 days, and most people's use feeling is good, relative to comparative example
1-5 highest effective percentage is only 36%, and embodiment 7-12 anti-wrinkle total effective rates are up to 100%, and it is bright to illustrate that anti-wrinkle Essence of the present invention has
Aobvious anti-wrinkle effect.
Comparative example 1-5 only adds deep-sea fish collagen peptide, cockscomb respectively compared with embodiment 7-9（CELOSIA
CRISTATA）Flower extract, the sharp leaf bark of ash（FRAXINUS SZABOANA）Extract, Epimedium（EPIMEDIUM
SAGITTATUM）Extract, folic acid, it was demonstrated that deep-sea fish collagen peptide, cockscomb（CELOSIA CRISTATA）Flower extract,
The sharp leaf bark of ash（FRAXINUS SZABOANA）Extract, Epimedium（EPIMEDIUM SAGITTATUM）Extract, folic acid
Effect is just notable when being the key component of anti-wrinkle Essence performance anti-wrinkle effect, and sharing, and embodies synergistic effect.Embodiment 10-
12 compared with embodiment 7-9, are added to Oxyria sinensis Hemsl（GOODYERA KWANGTUNGENSIS）Extract, data can from table
Go out, effect, which has, to be obviously improved, and shows Oxyria sinensis Hemsl（GOODYERA KWANGTUNGENSIS）The addition of extract can be notable
Promote the anti-wrinkle effect of anti-wrinkle composition.
Two moistening effect of experimental example is verified
1, trial target：Anti-wrinkle Essence prepared by embodiment 7-12, comparative example 1-5.
2, tested crowd's data and grouping：660 skin healths, the tested volunteer of women of no skin disease allergies, 30-
55 years old, average age 30 years old was randomly divided into 11 groups, every group of 60 people.
3, test method：The anti-wrinkle Essence prepared by example 7-12, comparative example 1-5, observation and impression is used to make respectively
Use effect.Application method：After subject cleans face, above-described embodiment and comparative example product are uniformly applied to face, gently
It is applied to skin all to absorb, each using once, adhering to using one month daily morning and evening, at least checking weekly once has to understand
Without whole body and local adverse reaction, and result is recorded in detail.
4, test assessment result is as shown in table 3 below：
Table 3
It can be seen that by above-mentioned table 3, the anti-wrinkle Essence of 7-12 of the embodiment of the present invention has relative to the anti-wrinkle Essence of comparative example 1-5
There is excellent replenishing water and preserving moisture effect.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of anti-wrinkle composition, it is characterised in that：The anti-wrinkle composition includes the component of following parts by weight：Deep-sea fish glue
Former protein peptides 1-5 parts, cockscomb（CELOSIA CRISTATA）1-10 parts of flower extract, the sharp leaf bark of ash（FRAXINUS
SZABOANA）1-10 parts of extract, Epimedium（EPIMEDIUM SAGITTATUM）1-10 parts of extract, 1-4 parts of folic acid.
2. anti-wrinkle composition according to claim 1, it is characterised in that：The anti-wrinkle composition further includes 0.1-5 weights
Measure the Oxyria sinensis Hemsl of part（GOODYERA KWANGTUNGENSIS）Extract.
3. a kind of preparation for external application to skin, which is characterized in that the preparation for external application to skin by dispelling as claimed in claim 1 or 2
Wrinkle composition, in addition the auxiliary material or complementary ingredient in cosmetic field are prepared.
4. preparation for external application to skin according to claim 3, which is characterized in that the additive amount of the anti-wrinkle composition is skin
The 0.1-5wt% of external preparation total amount.
5. preparation for external application to skin according to claim 3, which is characterized in that the auxiliary material in the cosmetic field or auxiliary
Property ingredient include one or more kinds of mixing in moisturizer, thickener, skin conditioning agent, preservative, chelating agent.
6. preparation for external application to skin according to claim 5, which is characterized in that the auxiliary material in the cosmetic field or auxiliary
Property ingredient further includes deionized water.
7. preparation for external application to skin according to claim 5, which is characterized in that the moisturizer includes Sodium Hyaluronate, fourth
Glycol, glycerine, arginine, phytosterol isostearate, two（Lauramide glutamine）Sodium lysinate, PCA sodium, hydrolysis
Silk, pungent glycol, 1,2- pentanediols, sucrose, trehalose, rhamnose, mannose, gossypose, glycine betaine, erythrite, xylitol,
One or more kinds of mixing in biological carbohydrate gum -2.
8. preparation for external application to skin according to claim 5, which is characterized in that the thickener include xanthans, carbomer,
One or more kinds of mixing in hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose；The skin tune
Reason agent includes tocopherol, niacinamide, bisabolol, Ascorbyl Tetraisopalmitate, pyridoxine dicaprylate, two palm fibre of pyridoxine
One or more kinds of mixing in glycerin monostearate, retinyl palmitate；The preservative includes Chlorphenesin, benzene oxygen second
One or more kinds of mixing in alcohol, potassium sorbate, sodium benzoate；The chelating agent includes EDTA disodiums, EDTA tetra-
One or more kinds of mixing in sodium.
9. a kind of such as claim 3-8 any one of them preparation for external application to skin, which is characterized in that the external preparation is gel
Agent, ointment, lotion, surfactant, Essence or facial mask.
10. application of the anti-wrinkle composition according to claim 1 or 2 in preparing anti-wrinkle external use skin care.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111789776A (en) * | 2020-08-03 | 2020-10-20 | 西安英创生物技术有限公司 | Application of PYCR1 protein in preparation of anti-oxidation anti-wrinkle mask and anti-oxidation anti-wrinkle mask |
-
2018
- 2018-08-06 CN CN201810887733.XA patent/CN108635306A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111789776A (en) * | 2020-08-03 | 2020-10-20 | 西安英创生物技术有限公司 | Application of PYCR1 protein in preparation of anti-oxidation anti-wrinkle mask and anti-oxidation anti-wrinkle mask |
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Application publication date: 20181012 |