CN108619417A - It recovers lost hearing only deaf capsule - Google Patents

It recovers lost hearing only deaf capsule Download PDF

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CN108619417A
CN108619417A CN201810919053.1A CN201810919053A CN108619417A CN 108619417 A CN108619417 A CN 108619417A CN 201810919053 A CN201810919053 A CN 201810919053A CN 108619417 A CN108619417 A CN 108619417A
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parts
capsule
radix
deaf
medicinal material
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赵婉汝
赵文贤
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Shaanxi Hui Fu Pharmaceutical Co Ltd
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Shaanxi Hui Fu Pharmaceutical Co Ltd
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Abstract

It recovers lost hearing only deaf capsule the invention discloses one kind, formula includes the medicinal material of following parts by weight:42 45 parts of rough gentian, 42 44 parts of radix scutellariae, 20 25 parts of cape jasmine, 16 19 parts of Chinese violet, 9 12 parts of cicada slough, 20 25 parts of rhizoma alismatis, 25 30 parts of lophatherum gracile, 25 28 parts of plantain seed, 16 19 parts of Radix Angelicae Sinensis, 16 19 parts of glutinous rehmannia, 10 13 parts of the membrane of a chicken's gizzard, 16 20 parts of radix bupleuri, 42 45 parts of Radix Glycyrrhizae.The present invention is packed into capsule using whole pulverizing medicinal materials at fine powder, and prepared by the technique that capsule is made, remain the active ingredient of drug to the greatest extent, has simple for process, easy to operate, curative for effect, the advantages that price is relatively cheap, and be conducive to patient's long-term use.

Description

It recovers lost hearing only deaf capsule
Technical field
It recovers lost hearing only deaf capsule the present invention relates to pharmaceutical technology field more particularly to one kind.
Background technology
Tinnitus, deafness are a kind of common disease, the frequently-occurring disease of elderly population.Tinnitus refers to patient and feels the sense for having ring in ear Feel and have no corresponding sound source in ambient enviroment, is a kind of sufficiently complex clinically extremely common symptom of cause of disease, usual companion There is agitation, dyscoimesis, absent minded, severe patient can influence work, amusement and social interaction.According to clinical statistics, 17% ~20% adult has tinnitus, and over-65s old man incidence is up to 28%, and tinnitus occurrence rate is up to 85% in ear disorder.Due to It is a kind of subjective feeling as pain, still lacks practicable objective detection means at present, also not to its mechanism Very it is illustrated, thus brings certain difficulty to clinical diagnosis, classification, treatment and curative effect evaluation, although is controlled applied to clinical There are many treatment method, such as psychotherapy, Masking, medicinal treatment, operative treatment, electrical stimulating therapy, biofeedback therapy, but Most therapies are not that tinnitus is made to disappear to the adaptation of tinnitus to promote patient, still obtaining medical field public affairs without one kind at present That recognizes has the therapy of definite curative effect.Tinnitus have become clinically in the urgent need to address and insoluble chronic disease it One;Deafness, which refers to patient, reduces the sensibility of sound in ambient enviroment.The sudden deafness cause of disease is not fully understood, modern medicine It is considered caused by virus infection and inner ear microcirculation obstacle.It cannot timely and effectively improve inner ear microcirculation as after the onset of, It will make hearing permanent loss.And Chinese medicine has unique advantage in this respect.The two symptoms for completely contradicting of Hiccough and deaf, face Often occur simultaneously on bed or successively occurs, although two card clinical manifestation modes are different, etiology and pathogenesis and Coryza Treated by Syndrome Differentiation principle It is essentially identical, therefore Chinese medicine by Hiccough and deaf and claims.Chinese medicine treatment is increasing blood flow, improve the blood circulation of inner ear, anti-freezing, Thrombolysis, protection inner ear capillary etc. have significant clinical meaning, keep patient's auditory rehabilitation very fast, tinnitus and vertigo symptoms It disappears, therefore clinic should promote and apply.
Currently, domestic mostly taken with using Chinese medicine that decoction is made to patient, but since decoction decocting, carrying are all inconvenient, It is not easy to patient medication, thus the only deaf capsule it is proposed that one kind is recovered lost hearing.
Invention content
Technical problems based on background technology, the present invention propose only deaf capsule of recovering lost hearing.
Only deaf capsule proposed by the present invention of recovering lost hearing, formula include the medicinal material of following parts by weight:42-45 parts of rough gentian, radix scutellariae 42- 44 parts, 20-25 parts of cape jasmine, 16-19 parts of Chinese violet, 9-12 parts of cicada slough, 20-25 parts of rhizoma alismatis, 25-30 parts of lophatherum gracile, plantain seed 25-28 parts, 16-19 parts of Radix Angelicae Sinensis, 16-19 parts of glutinous rehmannia, 10-13 parts of the membrane of a chicken's gizzard, 16-20 parts of radix bupleuri, 42-45 parts of Radix Glycyrrhizae.
Preferably, formula includes the medicinal material of following parts by weight:42 parts of rough gentian, 42 parts of radix scutellariae, 20 parts of cape jasmine, Chinese violet 16 Part, 9 parts of cicada slough, 20 parts of rhizoma alismatis, 25 parts of lophatherum gracile, 25 parts of plantain seed, 16 parts of Radix Angelicae Sinensis, 16 parts of glutinous rehmannia, 10 parts of the membrane of a chicken's gizzard, radix bupleuri 16 Part, 42 parts of Radix Glycyrrhizae.
Preferably, preparation method includes the following steps:
S1:It is prepared by raw material:According to traditional Chinese medicines standard the rough gentian of high-quality, radix scutellariae, cape jasmine, pale reddish brown is chosen from regular medium-height grass pharmacy Chinese violet, cicada slough, rhizoma alismatis, lophatherum gracile, plantain seed, Radix Angelicae Sinensis, glutinous rehmannia, the membrane of a chicken's gizzard, radix bupleuri, Radix Glycyrrhizae;
S2:Medicinal material is dried:Glutinous rehmannia described in S1 is put into baking oven and is dried, the temperature in baking oven is controlled in 60- 80℃;
S3:Medicinal material is mixed, is crushed:Glutinous rehmannia after drying described in S2 is uniformly mixed in proportion with remaining medicinal material, It is then placed in pulverizer and crushes, obtain medicinal material mixture A fine crushing;
S4:Sieving:Medicinal material mixture A described in S3 is filtered through filter, and filter is using No. six sieves, mistake Thin medicinal powder B is obtained after filter;
S5:Prepare capsule:Thin medicinal powder B described in S4 is filled to capsule ontology, capsule cap is set in capsule sheet It is sealed to obtain finished capsule product C on body and with sealing machine;
S6:The pharmacological property of finished capsule product detects:Finished capsule product C described in S5 is divided into three batches in finished capsule product C Radix scutellariae, Radix Glycyrrhizae, bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
Preferably, in the S2 drying box model 101A-2.
Preferably, in the S3, the model DLF-18 of pulverizer.
Preferably, in the S4, the model ZZ450 of filter.
Preferably, in the S6, pass through ZF-I types ultraviolet analysis instrument for three purposed, MJ-160 types mold incubator, positive-negative-positive electricity The equipment such as hot constant incubator, 101A-2 types drying box, SC69-02C type moisture tellers, by three batch finished capsule product C It is respectively placed in 37 DEG C -40 DEG C of temperature, under the conditions of relative humidity 75%, in 0 month, in January, 2 months, March, separately sampled progress was yellow A kind of reed mentioned in ancient books, Radix Glycyrrhizae, bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
Discussion to prescription:
(1) the sudden deafness cause of disease is not fully understood, and the main cause that modern medicine thinks is infected or interior by parotid gland virus Ear vascular thrombosis forms embolism, vessels of internal ear spasm, Abnormal Blood Rheology and causes caused by cochlea microcirculation disorder.Inner ear is micro- to follow Ischemic, anoxic caused by ring obstacle are the key pathological bases of sudden deafness.Zhu Honghai just proposes that blood is more equal to nineteen ninety-five Item flow variables Indexes Abnormality (blood viscosity, red blood cell are overstock, platelet aggregation rate increases) is to lead to ischaemic, the original of anoxic Cause.Ischemic, anoxic generation oxygen radical cause inner ear hair cells to damage, local organization oedema.Yin Tuanfang etc. researchs and proposes blood Middle red cell vitality substance reduces and the raising of the objects such as lipid peroxide is related with the generation of sudden deafness.As it can be seen that inner ear ischemia, lack Oxygen and microcirculation disorder are to lead to a particularly important pathologic basis of Sudden Deafness.
Chinese medicine thinks this disease by diseases caused by external factors heat toxin, and internal injury diet, feelings will etc. cause cult poison closing, convulsive seizure due to phlegm-fire pent-up, and phlegm, which becomes silted up, hinders network Close key;Or prolonged illness spleen kidney deficiency damage, vital essence are not filled;The sinking of qi of middle-jiao, caused by lucid yang failing to raise.It is common to have asthenia with sthenia but more with real example See, is invaded outside heat toxin, interior strongly fragrant key network;Or raw in convulsive seizure due to phlegm-fire, the bright channels of fire, liquid hinder network resistance silt life.Therefore in the same of eliminating pathogen to support vital qi in treatment When, should not ignore activate blood circulation and disperse blood clots, eliminating the phlegm it is sensible.Diseases caused by external factors heat toxin is treated, with expelling wind and clearing away heat, detoxifies and dredges key;There is fire to contain phlegm resistance, Using purging intense heat, eliminating the phlegm as the rules for the treatment of;The phlegm silt person that closes key, is controlled and is used in combination with resolving sputum with silt of dispelling, and dredging collateral and is had one's ideas straightened out parallel.Modern pharmacological research is demonstrate,proved Real, the energy resisting virus, eliminating inflammation such as heat-clearing and detoxifying drug rough gentian, radix scutellariae, cape jasmine has very well the inflammatory edema caused by acute parotid gland virus The effect of;Radix Angelicae Sinensis has improvement microcirculatory blood, anti-oxidant and Free Radical.Selection drug on the basis of differentiation of symptoms and signs for classification of syndrome, and It drinks plus activating blood and removing stasis drug can obtain good therapeutic effect.
One disease of tinnitus, is related to the five internal organs.Just how real ring is, and ring is mostly empty long.The liver lung spleen of real person's duty, the heart spleen kidney of empty person's duty, In especially with liver, kidney be it is most important.We are for treating liver and gall excess fire, and dampness-heat of liver channel follows swollen through above disturbing caused tinnitus, deafness, ear Equal diseases.《Yizong Jinjian Shan Buming hospital is discussed》Cloud:" costalgia bitter taste, deaf ear are swollen, are Liver Channel for disease.Therefore use felwort The fire of purging the liver of pathogenic fire courage, makes by liver of radix bupleuri, delays liver urgency with Radix Glycyrrhizae, assistant is made all damp and hot with a kind of reed mentioned in ancient books, Cape jasmine, logical, pool, the big sharp external genitalia of Chinese herbaceous peony generation Have so going out.So product of all purging the liver of pathogenic fires, if disease is made to go to the greatest extent, probably liver also hinders, thus again sovolin return, Radix Rehmanniae replenishing blood and nourishing liver, lid liver is The viscus of storing blood is enriched blood i.e. so tonifying liver, and the anti-medicine for making tonifying liver of the wonderful agent in purging the liver of pathogenic fire, and residence, which has to defeat, comforts peaceful justice." therefore this Just Longdan Xiegan Tang is selected to add and subtract using purging the liver of pathogenic fire courage excess fire as the rules for the treatment of in side.
(2) this disease therapy is had one's ideas straightened out with clearing heat-fire, removing toxic substances for the rules for the treatment of, selects Longdan Xiegan Tang to add and subtract, mainly for heat The diseases such as caused tinnitus, deafness, acute and chronic tympanitis are disturbed on poison.Select rough gentian big bitter Great Cold, upper purging the liver of pathogenic fire courage excess fire, lower clear lower coke in side It is damp and hot, the monarch drug in a prescription of its work(is arrogated to oneself for our purging intense heat dehumidifying two.Radix scutellariae, cape jasmine, Chinese violet have the work(of bitter cold purging intense heat;Cicada slough cool liver Ceases wind, in our compatibility rough gentian, is altogether ministerial drug for evacuating wind-heat of liver channel.Rhizoma alismatis, lophatherum gracile, plantain seed clearing heat and promoting diuresis, make wet Heat is excluded from water channel.Liver storing blood, Liver Channel have heat, this easy consumption impairment of yin blood, with the medicine of bitter-cold herbs easing dampness, then consume its moon, thus with glutinous rehmannia, Radix Angelicae Sinensis nourishing yin and nourishing blood;The membrane of a chicken's gizzard transports spleen promoting digestion and nourishing stomach.So that giving consideration to both the incidental and fundamental.It is adjutant altogether.Side's radix bupleuri is to enter liver to draw all medicines Courage and set;Radix Glycyrrhizae has the benefits of coordinating the drug actions of a prescription, to make medicine.Full side is taken a broad view of, is to have benefit in rushing down, has taste in profit, so that fire drop heat disappears, it is wet Turbid to distinguish, it is accordingly being cured to follow through sent out all diseases.
The detection of weight differential:
According to《Chinese Pharmacopoeia》Detection regulation under one annex of version in 2000, I L capsule weight differential items, takes finished product glue 10 groups of capsule, as a result see the table below by every group 10.
According to testing result, the weight differential of finished product is less than in pharmacopeia ± 8% regulation, meets the requirements ± 1~2%. The technique of only deaf capsule of illustrating to recover lost hearing is feasible.
【Composition】Rough gentian, radix scutellariae, cape jasmine, Chinese violet, periostracum cicada, rhizoma alismatis, lophatherum gracile, plantain seed, Radix Angelicae Sinensis, glutinous rehmannia, in chicken Gold, radix bupleuri, Radix Glycyrrhizae
【Character】This product is capsule, and content is brown ceramic powder;It is mildly bitter flavor, pungent.
【Major function】Key is dredged in heat-clearing wind-dispelling, removing toxic substances.Disturb caused deafness in heat toxin, tinnitus, acute and chronic tympanitis, Conduction deafness.
【Usage and dosage】It is oral, one time 3~6,3 times a day, children are cut down according to the circumstance.
【Contraindication】Avoid eating that Xin Leng is vinegar-pepper, is not taken by pregnant women.
【Specification】Every dress 0.4g
【Storage】Sealing.
【Packaging】50/bottle, plastic drug package.
【The term of validity】1 year.
Beneficial effects of the present invention:This technique is packed into capsule using whole pulverizing medicinal materials at fine powder, and the work of capsule is made Prepared by skill, remain the active ingredient of drug to the greatest extent, has simple for process, and easy to operate, curative for effect, price is relatively just The advantages that suitable, and be conducive to patient's long-term use.
Specific implementation mode
The present invention is made further to explain with reference to specific embodiment.
Embodiment one
Only deaf capsule of recovering lost hearing is proposed in the present embodiment, including only deaf capsule proposed by the present invention of recovering lost hearing, formula include with The medicinal material of lower parts by weight:42 parts of rough gentian, 42 parts of radix scutellariae, 20 parts of cape jasmine, 16 parts of Chinese violet, 9 parts of cicada slough, 20 parts of rhizoma alismatis, henon bamboo 25 parts of leaf, 25 parts of plantain seed, 16 parts of Radix Angelicae Sinensis, 16 parts of glutinous rehmannia, 10 parts of the membrane of a chicken's gizzard, 16 parts of radix bupleuri, 42 parts of Radix Glycyrrhizae.
It recovers lost hearing the preparation method of only deaf capsule, includes the following steps:
S1:It is prepared by raw material:According to traditional Chinese medicines standard the rough gentian of high-quality, radix scutellariae, cape jasmine, pale reddish brown is chosen from regular medium-height grass pharmacy Chinese violet, cicada slough, rhizoma alismatis, lophatherum gracile, plantain seed, Radix Angelicae Sinensis, glutinous rehmannia, the membrane of a chicken's gizzard, radix bupleuri, Radix Glycyrrhizae;
S2:Medicinal material is dried:Glutinous rehmannia described in S1 is put into baking oven and is dried, the temperature in baking oven is controlled 65 ℃;
S3:Medicinal material is mixed, is crushed:Glutinous rehmannia after drying described in S2 is uniformly mixed in proportion with remaining medicinal material, It is then placed in pulverizer and crushes, obtain medicinal material mixture A fine crushing;
S4:Sieving:Medicinal material mixture A described in S3 is filtered through filter, and filter is using No. six sieves, mistake Thin medicinal powder B is obtained after filter;
S5:Prepare capsule:Thin medicinal powder B described in S4 is filled to capsule ontology, capsule cap is set in capsule sheet It is sealed to obtain finished capsule product C on body and with sealing machine;
S6:The pharmacological property of finished capsule product detects:Finished capsule product C described in S5 is divided into three batches in finished capsule product C Radix scutellariae, Radix Glycyrrhizae, bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
The model 101A-2 of drying box in S2;In the S3, the model DLF-18 of pulverizer;In the S4, filtering The model ZZ450 of machine;It is permanent by ZF-I types ultraviolet analysis instrument for three purposed, MJ-160 types mold incubator, positive-negative-positive electric heating in S6 The equipment such as warm incubator, 101A-2 types drying box, SC69-02C type moisture tellers, by three batch finished capsule product C difference Be positioned over 37 DEG C of temperature, under the conditions of relative humidity 75%, in 0 month, January, 2 months, March separately sampled progress radix scutellariae, Radix Glycyrrhizae, thin Bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
Embodiment two
Only deaf capsule of recovering lost hearing is proposed in the present embodiment, including only deaf capsule proposed by the present invention of recovering lost hearing, formula include with The medicinal material of lower parts by weight:43 parts of rough gentian, 43 parts of radix scutellariae, 23 parts of cape jasmine, 17 parts of Chinese violet, 10 parts of cicada slough, 22 parts of rhizoma alismatis, henon bamboo 27 parts of leaf, 26 parts of plantain seed, 18 parts of Radix Angelicae Sinensis, 18 parts of glutinous rehmannia, 12 parts of the membrane of a chicken's gizzard, 18 parts of radix bupleuri, 44 parts of Radix Glycyrrhizae.
It recovers lost hearing the preparation method of only deaf capsule, includes the following steps:
S1:It is prepared by raw material:According to traditional Chinese medicines standard the rough gentian of high-quality, radix scutellariae, cape jasmine, pale reddish brown is chosen from regular medium-height grass pharmacy Chinese violet, cicada slough, rhizoma alismatis, lophatherum gracile, plantain seed, Radix Angelicae Sinensis, glutinous rehmannia, the membrane of a chicken's gizzard, radix bupleuri, Radix Glycyrrhizae;
S2:Medicinal material is dried:Glutinous rehmannia described in S1 is put into baking oven and is dried, the temperature in baking oven is controlled 75 ℃;
S3:Medicinal material is mixed, is crushed:Glutinous rehmannia after drying described in S2 is uniformly mixed in proportion with remaining medicinal material, It is then placed in pulverizer and crushes, obtain medicinal material mixture A fine crushing;
S4:Sieving:Medicinal material mixture A described in S3 is filtered through filter, and filter is using No. six sieves, mistake Thin medicinal powder B is obtained after filter;
S5:Prepare capsule:Thin medicinal powder B described in S4 is filled to capsule ontology, capsule cap is set in capsule sheet It is sealed to obtain finished capsule product C on body and with sealing machine;
S6:The pharmacological property of finished capsule product detects:Finished capsule product C described in S5 is divided into three batches in finished capsule product C Radix scutellariae, Radix Glycyrrhizae, bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
The model 101A-2 of drying box in S2;In the S3, the model DLF-18 of pulverizer;In the S4, filtering The model ZZ450 of machine;It is permanent by ZF-I types ultraviolet analysis instrument for three purposed, MJ-160 types mold incubator, positive-negative-positive electric heating in S6 The equipment such as warm incubator, 101A-2 types drying box, SC69-02C type moisture tellers, by three batch finished capsule product C difference Be positioned over 39 DEG C of temperature, under the conditions of relative humidity 75%, in 0 month, January, 2 months, March separately sampled progress radix scutellariae, Radix Glycyrrhizae, thin Bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
Embodiment three
Only deaf capsule of recovering lost hearing is proposed in the present embodiment, including only deaf capsule proposed by the present invention of recovering lost hearing, formula include with The medicinal material of lower parts by weight:45 parts of rough gentian, 44 parts of radix scutellariae, 24 parts of cape jasmine, 18 parts of Chinese violet, 11 parts of cicada slough, 24 parts of rhizoma alismatis, henon bamboo 28 parts of leaf, 27 parts of plantain seed, 19 parts of Radix Angelicae Sinensis, 19 parts of glutinous rehmannia, 13 parts of the membrane of a chicken's gizzard, 19 parts of radix bupleuri, 45 parts of Radix Glycyrrhizae.
It recovers lost hearing the preparation method of only deaf capsule, includes the following steps:
S1:It is prepared by raw material:According to traditional Chinese medicines standard the rough gentian of high-quality, radix scutellariae, cape jasmine, pale reddish brown is chosen from regular medium-height grass pharmacy Chinese violet, cicada slough, rhizoma alismatis, lophatherum gracile, plantain seed, Radix Angelicae Sinensis, glutinous rehmannia, the membrane of a chicken's gizzard, radix bupleuri, Radix Glycyrrhizae;
S2:Medicinal material is dried:Glutinous rehmannia described in S1 is put into baking oven and is dried, the temperature in baking oven is controlled 80 ℃;
S3:Medicinal material is mixed, is crushed:Glutinous rehmannia after drying described in S2 is uniformly mixed in proportion with remaining medicinal material, It is then placed in pulverizer and crushes, obtain medicinal material mixture A fine crushing;
S4:Sieving:Medicinal material mixture A described in S3 is filtered through filter, and filter is using No. six sieves, mistake Thin medicinal powder B is obtained after filter;
S5:Prepare capsule:Thin medicinal powder B described in S4 is filled to capsule ontology, capsule cap is set in capsule sheet It is sealed to obtain finished capsule product C on body and with sealing machine;
S6:The pharmacological property of finished capsule product detects:Finished capsule product C described in S5 is divided into three batches in finished capsule product C Radix scutellariae, Radix Glycyrrhizae, bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
The model 101A-2 of drying box in S2;In the S3, the model DLF-18 of pulverizer;In the S4, filtering The model ZZ450 of machine;It is permanent by ZF-I types ultraviolet analysis instrument for three purposed, MJ-160 types mold incubator, positive-negative-positive electric heating in S6 The equipment such as warm incubator, 101A-2 types drying box, SC69-02C type moisture tellers, by three batch finished capsule product C difference Be positioned over 40 DEG C of temperature, under the conditions of relative humidity 75%, in 0 month, January, 2 months, March separately sampled progress radix scutellariae, Radix Glycyrrhizae, thin Bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
Integrated embodiment one, embodiment two and embodiment three, radix scutellariae, Radix Glycyrrhizae, bacterium, mould, large intestine bar in finished capsule product G The testing result that bacterium, moisture and appearance dissipate property is as follows:
Testing result one
Testing result two
Testing result three
Analysis of test results:
Root Ju we to three batches of sample reserved sample observings of preparation as a result, " only deaf capsule of recovering lost hearing " in appearance character, differentiate, defend Raw, moisture, dissolution etc. all change without conspicuousness, meet the requirement for the only deaf capsule quality standard of recovering lost hearing, show " to answer Acute hearing stops deaf capsule " it is more stable.In addition, only deaf capsule of recovering lost hearing is packed for the life of Hebei province Cang County rehabilitation acceptable packaging material factory The medicinal plastic bottle of oral administration solid of production is on the quality of preparation without influence, this preparation is stable during the experiment, and preparation can fix tentatively Storage life is 1 year.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (7)

1. only deaf capsule of recovering lost hearing, which is characterized in that formula includes the medicinal material of following parts by weight:42-45 parts of rough gentian, radix scutellariae 42-44 Part, 20-25 parts of cape jasmine, 16-19 parts of Chinese violet, 9-12 parts of cicada slough, 20-25 parts of rhizoma alismatis, 25-30 parts of lophatherum gracile, plantain seed 25- 28 parts, 16-19 parts of Radix Angelicae Sinensis, 16-19 parts of glutinous rehmannia, 10-13 parts of the membrane of a chicken's gizzard, 16-20 parts of radix bupleuri, 42-45 parts of Radix Glycyrrhizae.
2. only deaf capsule according to claim 1 of recovering lost hearing, which is characterized in that formula includes the medicinal material of following parts by weight:Dragon 42 parts of courage, 42 parts of radix scutellariae, 20 parts of cape jasmine, 16 parts of Chinese violet, 9 parts of cicada slough, 20 parts of rhizoma alismatis, 25 parts of lophatherum gracile, 25 parts of plantain seed, 16 parts of Radix Angelicae Sinensis, 16 parts of glutinous rehmannia, 10 parts of the membrane of a chicken's gizzard, 16 parts of radix bupleuri, 42 parts of Radix Glycyrrhizae.
3. the preparation method of the only deaf capsule according to claim 1 or 2 of recovering lost hearing, which is characterized in that include the following steps:
S1:It is prepared by raw material:According to traditional Chinese medicines standard the rough gentian of high-quality, radix scutellariae, cape jasmine, pale reddish brown is chosen from regular medium-height grass pharmacy Fourth, cicada slough, rhizoma alismatis, lophatherum gracile, plantain seed, Radix Angelicae Sinensis, glutinous rehmannia, the membrane of a chicken's gizzard, radix bupleuri, Radix Glycyrrhizae;
S2:Medicinal material is dried:Glutinous rehmannia described in S1 is put into baking oven and is dried, the temperature in baking oven is controlled at 60-80 DEG C;
S3:Medicinal material is mixed, is crushed:Glutinous rehmannia after drying described in S2 is uniformly mixed in proportion with remaining medicinal material, then It is put into pulverizer and crushes, obtain medicinal material mixture A fine crushing;
S4:Sieving:Medicinal material mixture A described in S3 is filtered through filter, and filter is sieved using No. six, after filtering Obtain thin medicinal powder B;
S5:Prepare capsule:Thin medicinal powder B described in S4 is filled to capsule ontology, capsule cap is set on capsule ontology It is used in combination sealing machine to be sealed to obtain finished capsule product C;
S6:The pharmacological property of finished capsule product detects:By the finished capsule product C described in S5 be divided into three batches to radix scutellariae in finished capsule product C, Radix Glycyrrhizae, bacterium, mould, Escherichia coli, moisture and appearance dissipate property and are detected.
4. the preparation method of the only deaf capsule according to claim 3 of recovering lost hearing, which is characterized in that the type of drying box in the S2 Number be 101A-2.
5. the preparation method of the only deaf capsule according to claim 3 of recovering lost hearing, which is characterized in that in the S3, pulverizer Model DLF-18.
6. the preparation method of the only deaf capsule according to claim 3 of recovering lost hearing, which is characterized in that in the S4, filter Model ZZ450.
7. the preparation method of the only deaf capsule according to claim 3 of recovering lost hearing, which is characterized in that in the S6, pass through ZF-I Type ultraviolet analysis instrument for three purposed, MJ-160 types mold incubator, positive-negative-positive electro-heating standing-temperature cultivator, 101A-2 types drying box, SC69- Three batch finished capsule product C are respectively placed in 37 DEG C -40 DEG C of temperature, relative humidity by the equipment such as 02C type moisture tellers Under the conditions of 75%, in 0 month, January, 2 months, March separately sampled progress radix scutellariae, Radix Glycyrrhizae, bacterium, mould, Escherichia coli, moisture and appearance Scattered property is detected.
CN201810919053.1A 2018-08-14 2018-08-14 It recovers lost hearing only deaf capsule Pending CN108619417A (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1723945A (en) * 2005-07-06 2006-01-25 王衡新 Novel oral liquor for invigorating spleen, and prepn. method and quality control therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1723945A (en) * 2005-07-06 2006-01-25 王衡新 Novel oral liquor for invigorating spleen, and prepn. method and quality control therefor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
刘勇等: "中西医结合治疗突发性耳聋48例临床研究", 《江苏中医药》 *
国家药典委员会: "《国家食品药品监督管理局 国家药品标准 新药转正标准 第62册》", 31 December 2008, 人民卫生出版社 *
孙黎明: "浅论龙胆泻肝汤", 《中外健康文摘》 *
左言富等: "《简明中成药辞典》", 31 October 2002, 上海科学技术出版社 *
张兆东等: "突发性耳聋、耳鸣患者应用龙胆泻肝泻肝胶囊对血清sVCAM-1、免疫球蛋白及SOD水平影响研究", 《中国生化药物杂志》 *
老李638: "刘维忠主任运用龙胆泻肝汤加减治愈耳鸣、耳聋的临床案例举隅", 《WWW.360DOC.COM/CONTENT/17/1212/02/12682752_712274831.SHTML》 *

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