CN108619412A - 白茅根鲜提喷雾干燥颗粒饮片 - Google Patents
白茅根鲜提喷雾干燥颗粒饮片 Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 23
- 239000008187 granular material Substances 0.000 title claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000012141 concentrate Substances 0.000 claims abstract description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000005469 granulation Methods 0.000 claims abstract description 3
- 230000003179 granulation Effects 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 2
- 239000008399 tap water Substances 0.000 claims description 2
- 235000020679 tap water Nutrition 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 235000020985 whole grains Nutrition 0.000 abstract description 3
- 238000009461 vacuum packaging Methods 0.000 abstract 1
- 238000003860 storage Methods 0.000 description 3
- 241001598107 Imperata Species 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000030090 Acute Disease Diseases 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 210000000697 sensory organ Anatomy 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
本发明公布了一种“白茅根鲜提喷雾干燥颗粒饮片”，其主要特征在于：在白茅根采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩后喷雾干燥，制粒、整粒、真空包装。颗粒饮片的含水量少于10%。本饮片质量稳定，既可以入汤剂煎煮，也可以直接入胶囊、片剂中，利于携带，临床使用方便。
Description
技术领域
本发明属于中药饮片技术领域，尤其属于白茅根饮片的加工领域。
背景技术
中药白茅根为禾本科植物白茅Imperata cylindrica Beauv.var.major（Nees）C.E.Hubb.的干燥根茎，具有凉血止血，清热利尿的功效。主要用于血热吐血，衄血，尿血，热病烦渴，湿热黄疸，水肿尿少，热淋涩痛等的治疗，是中医临床上常见的一味中药。传统白茅根的加工方法为：将药材采挖后，洗净，晒干，除去须根和膜质叶鞘，捆成小把，打包，储运。到饮片厂后，再洗涤、润软、切片、干燥、包装。由此得到的白茅根饮片体积大，卫生学条件差，易于受潮，不利于保管，储存和运输成本高。此外，这样的饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型白茅根饮片，势在必行。目前市场白茅根饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成份。
发明内容
本发明公布了一种“白茅根鲜提喷雾干燥颗粒饮片”，其主要特征在于：在白茅根采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10的浓缩液。所得浓缩液留取1%~3%备用，其余喷雾干燥。将收集的喷干粉与备用的浓缩液混合制粒，干燥至含水量低于10%，整粒，真空包装，即得成品。白茅根颗粒饮片质量稳定，流动性好，临床一般使用量为1~5g。此类饮片既可入汤剂煎服、冲服，也可直接入胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统白茅根饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将白茅根药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.05。将所得的浓缩液留取3%备用，其余的喷雾干燥。收集喷干粉，与备用的浓缩液混合制颗粒，80℃真空干燥至含水量为10%，整粒，真空包装，即得成品。
Claims (2)
1.一种白茅根鲜提喷雾干燥颗粒饮片，其主要特征在于：在白茅根采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10；所得浓缩液留取1%~3%备用，其余喷雾干燥；将收集的喷干粉与备用的浓缩液混合制粒，干燥至含水量低于10%，整粒，真空包装，即得成品1。
2.根据权利要求1所述的白茅根鲜提喷雾干燥颗粒饮片，其主要特征在于：临床一般使用量为1~5g，本饮片既可入汤剂煎服、冲服，也可直接入胶囊剂及片剂中。
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213551A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106109623A (zh) * | 2016-07-31 | 2016-11-16 | 徐漫 | 一种翻白草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN107375529A (zh) * | 2017-08-25 | 2017-11-24 | 徐漫 | 一种白英鲜榨喷雾干燥颗粒饮片的制备工艺 |
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- 2018-07-06 CN CN201810733170.9A patent/CN108619412A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105213551A (zh) * | 2015-11-14 | 2016-01-06 | 芜湖天成普阳中药科技有限公司 | 一种白花蛇舌草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN106109623A (zh) * | 2016-07-31 | 2016-11-16 | 徐漫 | 一种翻白草鲜榨喷雾干燥颗粒饮片及其制备工艺 |
| CN107375529A (zh) * | 2017-08-25 | 2017-11-24 | 徐漫 | 一种白英鲜榨喷雾干燥颗粒饮片的制备工艺 |
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