CN108524563A - 羌活鲜提真空干燥粉末饮片 - Google Patents

羌活鲜提真空干燥粉末饮片 Download PDF

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CN108524563A
CN108524563A CN201810733380.8A CN201810733380A CN108524563A CN 108524563 A CN108524563 A CN 108524563A CN 201810733380 A CN201810733380 A CN 201810733380A CN 108524563 A CN108524563 A CN 108524563A
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rhizoma
radix notopterygii
decoction
fresh
water
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徐漫
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237—Notopterygium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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Abstract

本发明公布了一种“羌活鲜提真空干燥粉末饮片”，其主要特征在于：在羌活采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩成清膏后，再真空干燥至含水量少于10%，粉碎、过筛后真空包装。本饮片质量稳定，既可以入汤剂煎煮，也可以直接入丸剂、散剂、片剂、胶囊剂，利于携带，临床使用方便。

Description

羌活鲜提真空干燥粉末饮片
技术领域
本发明属于中药饮片技术领域，尤其属于羌活饮片的加工领域。
背景技术
中药羌活为伞形科植物羌活Notopterygium inchum Ting ex H，T- Chang 或宽叶羌活 Notopterygium franchetii H. de Boiss. 的干燥根茎和根，具有解表散寒，祛风除湿，止痛的功效。本品主要用于风寒感冒，头痛项强，风湿痹痛，肩背酸痛等的治疗，是中医临床上常见的一味中药。传统羌活的加工方法为：春、秋二季采挖，除去须根及泥沙，晒干，打包，储运。到饮片厂后，再洗涤、润软、切片、干燥、包装。如此加工的饮片体积大，卫生学标准差，易于受潮、长霉，不利于保管，储存和运输成本高。此外，这样的羌活饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型羌活饮片，势在必行。目前市场上的羌活饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“羌活鲜提真空干燥粉末饮片”，其主要特征在于：在羌活采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏。将所得的清膏在60~80℃下真空干燥至含水量低于10%，粉碎，过60目筛，真空包装，即得成品。成品饮片含羌活醇（C21H22O5）和异欧前胡素（C16H14O4）的总量不少于0.60%。本羌活饮片临床一般使用量为1~5g，既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统羌活饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将羌活药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.20的清膏。将所得的清膏于80℃下真空干燥至含水量为8%，粉碎，过60目筛，真空包装，即得成品。成品饮片含羌活醇（C21H22O5）和异欧前胡素（C16H14O4）的总量为0.70%。

Claims (2)

1.一种羌活鲜提真空干燥粉末饮片，其主要特征在于：在羌活采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.15~1.25的清膏；将所得的清膏在60~80℃下真空干燥至含水量低于10%，粉碎，过60目筛，真空包装，即得成品；成品饮片含羌活醇（C21H22O5）和异欧前胡素（C16H14O4）的总量不少于0.60%。
2.根据权利要求1所述的羌活鲜提真空干燥粉末饮片，其主要特征在于：临床一般使用量为1~5g，既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中。
CN201810733380.8A 2018-07-06 2018-07-06 羌活鲜提真空干燥粉末饮片 Withdrawn CN108524563A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113759045A (zh) * 2021-09-13 2021-12-07 北京康仁堂药业有限公司 羌活饮片或配方颗粒的特征图谱及其构建方法、羌活配方颗粒及其制备方法和质量控制方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113759045A (zh) * 2021-09-13 2021-12-07 北京康仁堂药业有限公司 羌活饮片或配方颗粒的特征图谱及其构建方法、羌活配方颗粒及其制备方法和质量控制方法

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Application publication date: 20180914