CN108567846A - 胡黄连鲜提喷雾干燥颗粒饮片 - Google Patents
胡黄连鲜提喷雾干燥颗粒饮片 Download PDFInfo
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Abstract
本发明公布了一种“胡黄连鲜提喷雾干燥颗粒饮片”,其主要特征在于:在胡黄连采收后,趁鲜洗涤、切片、榨汁、提取,提取液浓缩后喷雾干燥,制粒、整粒、真空包装。颗粒饮片的含水量少于10%,成品饮片含胡黄连苷I(C24H28O11)与胡黄连苷II(C23H28O13)的总量不少于10.0%。本饮片质量稳定,既可以入汤剂煎煮,也可以直接入胶囊、片剂中,利于携带,临床使用方便。
Description
技术领域
本发明属于中药饮片技术领域,尤其属于胡黄连饮片的加工领域。
背景技术
中药胡黄连为玄参科植物胡黄连 Picrorhiza scrophulariiflora Pennell 的干燥根茎,具有退虚热,除疳热,清湿热的功效。本品主要用于骨蒸潮热,小儿疳热,湿热泻痢,黄疸尿赤,痔疮肿痛等症的治疗,是中医临床上常见的一味中药。传统胡黄连的加工方法为:将药材采挖后,除去须根和泥沙,晒干,打包,储运。到饮片厂后,再洗涤、润软、切片、干燥、包装。由此得到的胡黄连饮片体积大,卫生学标准差,易于受潮、长霉,不利于保管,储存和运输成本高。此外,这样的饮片质量稳定性差,临床疗效难以保障,病人服用不方便,起效慢。因此,开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型胡黄连饮片,势在必行。目前市场胡黄连饮片,除了传统饮片之外,还有超微粉饮片和浓缩颗粒饮片两种形式,但两者都是以传统饮片为原料,其质量决定于传统饮片的质量,且超微饮片不能解决药材污染的问题;浓缩颗粒只能提取出水溶性成份。
发明内容
本发明公布了一种“胡黄连鲜提喷雾干燥颗粒饮片”,其主要特征在于:在胡黄连采收后,及时净选,去除泥沙等杂质和非药用部位,于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中,浸泡并时时搅拌5~30分钟,过滤,药渣压榨取汁。所得药渣中再加入5~10倍重量的水,煮沸10~30分钟,趁热过滤,药渣再次榨汁,收集药汁。合并上述药汁,过60~100目筛,减压浓缩,温度为50~75℃,浓缩至相对密度为1.02~1.10的浓缩液。所得浓缩液留取1%~3%备用,其余喷雾干燥。将收集的喷干粉与备用的浓缩液混合制粒,干燥至含水量低于10%,整粒,真空包装,即得成品。成品饮片含胡黄连苷I(C24H28O11)与胡黄连苷II(C23H28O13)的总量不少于10.0%。胡黄连颗粒饮片质量稳定,流动性好,临床一般使用量为1~5g。此类饮片既可入汤剂煎服、冲服,也可直接入胶囊剂及片剂中,从而大大提高了临床使用的便捷性和顺应性,有利于临床急症的治疗。
本发明解决了传统胡黄连饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点,由于是趁鲜提取,质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将胡黄连药材采收后,净选,除去泥沙等杂质和非药用部位,在6小时内趁鲜用自来水洗净,并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水,搅拌30分钟,过滤,药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水,煮沸20分钟提取,趁热过滤,药渣再次榨汁,收集药汁。合并上述药汁,减压浓缩,温度为设定为70℃,浓缩至相对密度为1.05。将所得的浓缩液留取3%备用,其余的喷雾干燥。收集喷干粉,与备用的浓缩液混合制颗粒,80℃真空干燥至含水量为10%,整粒,真空包装,即得成品。成品饮片含胡黄连苷I(C24H28O11)与胡黄连苷II(C23H28O13)的总量为10.5%。
Claims (2)
1.一种胡黄连鲜提喷雾干燥颗粒饮片,其主要特征在于:在胡黄连采收后,及时净选,去除泥沙等杂质和非药用部位,于24小时内趁鲜用自来水洗净并切成2~5mm厚的片,加入1~5倍重量50~70℃的水,浸泡并时时搅拌5~30分钟,过滤,药渣压榨取汁;所得药渣中再加入5~10倍重量的水,煮沸10~30分钟,趁热过滤,药渣再次榨汁,收集药汁;合并上述药汁,过60~100目筛,减压浓缩,温度为50~75℃,浓缩至相对密度为1.02~1.10;所得浓缩液留取1%~3%备用,其余喷雾干燥;将收集的喷干粉与备用的浓缩液混合制粒,干燥至含水量低于10%,整粒,真空包装,即得成品;成品饮片含胡黄连苷I(C24H28O11)与胡黄连苷II(C23H28O13)的总量不少于10.0%。
2.根据权利要求1所述的胡黄连鲜提喷雾干燥颗粒饮片,其主要特征在于:临床一般使用量为1~5g,本饮片既可入汤剂煎服、冲服,也可直接入胶囊剂及片剂中。
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