CN108524557A - 续断鲜提喷雾干燥颗粒饮片 - Google Patents

续断鲜提喷雾干燥颗粒饮片 Download PDF

Info

Publication number
CN108524557A
CN108524557A CN201810733315.5A CN201810733315A CN108524557A CN 108524557 A CN108524557 A CN 108524557A CN 201810733315 A CN201810733315 A CN 201810733315A CN 108524557 A CN108524557 A CN 108524557A
Authority
CN
China
Prior art keywords
materical crude
medicine materical
crude slice
fresh
teasel root
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201810733315.5A
Other languages
English (en)
Inventor
徐自升
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CN201810733315.5A priority Critical patent/CN108524557A/zh
Publication of CN108524557A publication Critical patent/CN108524557A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明公布了“一种续断鲜提喷雾干燥颗粒饮片”，其主要特征在于：在续断采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩后喷雾干燥，制粒、整粒、真空包装。颗粒饮片的含水量少于10%。本饮片质量稳定，既可以入汤剂煎煮，也可以直接入胶囊、片剂中，利于携带，临床使用方便。

Description

续断鲜提喷雾干燥颗粒饮片
技术领域
本发明属于中药饮片技术领域，尤其属于续断饮片的加工领域。
背景技术
中药续断为川续断科植物川续断Dipsacus asper Wall. ex Henry的干燥根，具有补肝肾，强筋骨，续折伤，止崩漏的功效。主要用于肝肾不足，腰膝酸软，风湿痹痛，跌扑损伤，筋伤骨折，崩漏，胎漏。酒续断多用于风湿痹痛，跌扑损伤，筋伤骨折等的治疗，是中医临床上常见的一味中药。传统续断的加工方法为：将药材采挖后，除去根头和须根，用微火烘至半干，堆置“发汗”至内部变绿色时，再烘干，打包，储运。到饮片厂后，再洗涤、润软、切片、干燥、包装。由此得到的续断饮片体积大，卫生学标准差，易于受潮、长霉，不利于保管，储存和运输成本高。此外，这样的饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型续断饮片，势在必行。目前市场续断饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“续断鲜提喷雾干燥颗粒饮片”，其主要特征在于：在续断采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10的浓缩液。所得浓缩液留取1%~3%备用，其余喷雾干燥。将收集的喷干粉与备用的浓缩液混合制粒，干燥至含水量低于10%，整粒，真空包装，即得成品。成品饮片含川续断皂苷Ⅵ（C47H76O18）不得少于3.0%。续断颗粒饮片质量稳定，流动性好，临床一般使用量为1~5g。此类饮片既可入汤剂煎服、冲服，也可直接入胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统续断饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将续断药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.05。将所得的浓缩液留取3%备用，其余的喷雾干燥。收集喷干粉，与备用的浓缩液混合制颗粒，80℃真空干燥至含水量为10%，整粒，真空包装，即得成品。成品饮片中川续断皂苷Ⅵ（C47H76O18）的含量为4.0%。

Claims (2)

1.一种续断鲜提喷雾干燥颗粒饮片，其主要特征在于：在续断采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10；所得浓缩液留取1%~3%备用，其余喷雾干燥；将收集的喷干粉与备用的浓缩液混合制粒，干燥至含水量低于10%，整粒，真空包装，即得成品；成品饮片含川续断皂苷Ⅵ（C47H76O18）不得少于3.0%。
2.根据权利要求1所述的续断鲜提喷雾干燥颗粒饮片，其主要特征在于：临床一般使用量为1~5g，本饮片既可入汤剂煎服、冲服，也可直接入胶囊剂及片剂中。
CN201810733315.5A 2018-07-06 2018-07-06 续断鲜提喷雾干燥颗粒饮片 Withdrawn CN108524557A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810733315.5A CN108524557A (zh) 2018-07-06 2018-07-06 续断鲜提喷雾干燥颗粒饮片

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810733315.5A CN108524557A (zh) 2018-07-06 2018-07-06 续断鲜提喷雾干燥颗粒饮片

Publications (1)

Publication Number Publication Date
CN108524557A true CN108524557A (zh) 2018-09-14

Family

ID=63487639

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810733315.5A Withdrawn CN108524557A (zh) 2018-07-06 2018-07-06 续断鲜提喷雾干燥颗粒饮片

Country Status (1)

Country Link
CN (1) CN108524557A (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115414397A (zh) * 2022-09-14 2022-12-02 广州中医药大学第三附属医院 续断源性细胞外囊泡样纳米颗粒在制备预防或治疗骨科疾病药物中的应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115414397A (zh) * 2022-09-14 2022-12-02 广州中医药大学第三附属医院 续断源性细胞外囊泡样纳米颗粒在制备预防或治疗骨科疾病药物中的应用

Similar Documents

Publication Publication Date Title
CN108524557A (zh) 续断鲜提喷雾干燥颗粒饮片
CN108524560A (zh) 独活鲜提喷雾干燥颗粒饮片
CN108671030A (zh) 肉苁蓉鲜提喷雾干燥颗粒饮片
CN108578587A (zh) 天麻鲜提喷雾干燥颗粒饮片
CN108524588A (zh) 杜仲鲜提喷雾干燥颗粒饮片
CN108619190A (zh) 羌活鲜提喷雾干燥颗粒饮片
CN108619250A (zh) 金荞麦鲜提喷雾干燥颗粒饮片
CN108619304A (zh) 地黄鲜提喷雾干燥颗粒饮片
CN108635382A (zh) 狗脊鲜提喷雾干燥颗粒饮片
CN108653363A (zh) 苍术鲜提喷雾干燥颗粒饮片
CN108619181A (zh) 川牛膝鲜提喷雾干燥颗粒饮片
CN108567806A (zh) 木香鲜提喷雾干燥颗粒饮片
CN108653424A (zh) 地榆鲜提喷雾干燥颗粒饮片
CN108635436A (zh) 巴戟天鲜提喷雾干燥颗粒饮片
CN108619180A (zh) 锁阳鲜提喷雾干燥颗粒饮片
CN108567846A (zh) 胡黄连鲜提喷雾干燥颗粒饮片
CN108635386A (zh) 川芎鲜提喷雾干燥颗粒饮片
CN108635384A (zh) 白芷鲜提喷雾干燥颗粒饮片
CN108771724A (zh) 香附鲜提喷雾干燥颗粒饮片
CN108771698A (zh) 木香鲜提喷雾干燥粉末饮片
CN108553520A (zh) 白头翁鲜提喷雾干燥粉末饮片
CN108619238A (zh) 乌药鲜提喷雾干燥颗粒饮片
CN108619249A (zh) 远志鲜提喷雾干燥颗粒饮片
CN108635387A (zh) 川芎鲜提喷雾干燥粉末饮片
CN108567828A (zh) 升麻鲜提喷雾干燥颗粒饮片

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20180914

WW01 Invention patent application withdrawn after publication