CN108619253A - 何首乌鲜提喷雾干燥粉末饮片 - Google Patents
何首乌鲜提喷雾干燥粉末饮片 Download PDFInfo
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 7
- 239000012141 concentrate Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims abstract description 5
- 241001289529 Fallopia multiflora Species 0.000 claims abstract description 4
- 239000002775 capsule Substances 0.000 claims abstract description 3
- 238000003306 harvesting Methods 0.000 claims abstract description 3
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- 244000291564 Allium cepa Species 0.000 claims description 3
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims description 3
- 239000010282 Emodin Substances 0.000 claims description 3
- UGNZSMZSJYOGNX-UHFFFAOYSA-N Isoviocristine Natural products O=C1C=C(C)C(=O)C2=CC3=CC(OC)=CC(O)=C3C(O)=C21 UGNZSMZSJYOGNX-UHFFFAOYSA-N 0.000 claims description 3
- WLXGUTUUWXVZNM-UHFFFAOYSA-N anthraglycoside A Natural products C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1OC1OC(CO)C(O)C(O)C1O WLXGUTUUWXVZNM-UHFFFAOYSA-N 0.000 claims description 3
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
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- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 claims description 3
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- 239000008399 tap water Substances 0.000 claims description 2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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Abstract
本发明公布了一种“何首乌鲜提喷雾干燥粉末饮片”，其主要特征在于：在何首乌药材采收后，趁鲜洗涤、切片、榨汁、提取，提取液浓缩后喷雾干燥，粉碎、过筛后真空包装。粉末饮片的含水量少于10%。此类饮片质量稳定，既可以入汤剂煎煮，也可以直接入丸剂、散剂、片剂、胶囊剂等，利于携带，临床使用方便。
Description
技术领域
本发明属于中药饮片技术领域，尤其属于何首乌饮片的加工领域。
背景技术
中药何首乌为蓼科植物何首乌Polygonum multijiorum Thunb.的干燥块根，具有解毒，消痈，截疟，润肠通便的功效。本品主要用于疮痈，瘰疬，风疹瘙痒，久疟体虚，肠燥便秘的治疗，是中医临床上常见的一味中药。传统何首乌的加工方法为：秋、冬二季叶枯萎时采挖，削去两端，洗净，个大的切成块，干燥，打包，储运。到饮片厂后，再洗涤、润软、切片、干燥、包装。此类饮片体积大，卫生学标准差，易于受潮、长霉、生虫，不利于保管，储存和运输成本高。此外，这样的饮片质量稳定性差，临床疗效难以保障，病人服用不方便，起效慢。因此，开发一种质量稳定可靠、储存/运输成本低、利于保管、携带和使用方便、起效快的新型何首乌饮片，势在必行。目前市场何首乌饮片，除了传统饮片之外，还有超微粉饮片和浓缩颗粒饮片两种形式，但两者都是以传统饮片为原料，其质量决定于传统饮片的质量，且超微饮片不能解决药材污染的问题；浓缩颗粒只能提取出水溶性成分。
发明内容
本发明公布了一种“何首乌鲜提喷雾干燥粉末饮片”，其主要特征在于：在何首乌药材采收后，及时净选，去除泥沙等杂质和非药用部位，于24小时内趁鲜用自来水洗净并切成2~5mm厚的片。将此切好的片加入1~5倍重量50~70℃的水中，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁。所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10的浓缩液。将所得的浓缩液喷雾干燥，控制干燥物含水量为10%以内，粉碎，过60目筛，真空包装，即得成品。成品饮片含结合蔥醌以大黄素（C15H10O5）和大黄素甲醚（C16H12O5）的总量计，不得少于0.20%。本粉末饮片临床一般使用量为1~5g，既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中，从而大大提高了临床使用的便捷性和顺应性，有利于临床急症的治疗。
本发明解决了传统何首乌饮片体积庞大、储运成本高、不利于保管、易生霉生虫、卫生学条件差、质量不稳定等诸多缺点，由于是趁鲜提取，质量比超微粉碎饮片和浓缩颗粒饮片更好。
具体实施例
将何首乌药材采收后，净选，除去泥沙等杂质和非药用部位，在6小时内趁鲜用自来水洗净，并切成3mm厚的片。将此片加入5倍重量的70℃的纯净水，搅拌30分钟，过滤，药渣压榨取汁。 再往上述药渣中再加入8倍重量的纯净水，煮沸20分钟提取，趁热过滤，药渣再次榨汁，收集药汁。合并上述药汁，减压浓缩，温度为设定为70℃，浓缩至相对密度为1.05。将所得的浓缩液喷雾干燥，至含水量为10%，粉碎，过60目筛，真空包装，即得成品。成品饮片含结合蔥醌以大黄素（C15H10O5）和大黄素甲醚（C16H12O5）的总量计，为0.26%。
Claims (2)
1.一种何首乌鲜提喷雾干燥粉末饮片，其主要特征在于：在何首乌药材采收后，及时净选，去除泥沙等杂质和非药用部位，于12小时内趁鲜用自来水洗净并切成2~5mm厚的片，加入1~5倍重量50~70℃的水，浸泡并时时搅拌5~30分钟，过滤，药渣压榨取汁；所得药渣中再加入5~10倍重量的水，煮沸10~30分钟，趁热过滤，药渣再次榨汁，收集药汁；合并上述药汁，过60~100目筛，减压浓缩，温度为50~75℃，浓缩至相对密度为1.02~1.10；所得浓缩液喷雾干燥，控制干燥物含水量为10%以内，粉碎，过60目筛，真空包装，即得成品；成品饮片含结合蔥醌以大黄素（C15H10O5）和大黄素甲醚（C16H12O5）的总量计，不得少于0.20%。
2.根据权利要求1所述的何首乌鲜提喷雾干燥粉末饮片，其主要特征在于：临床一般使用量为1~5g，此类饮片既可入汤剂煎服、冲服，也可直接入丸剂、散剂、胶囊剂及片剂中。
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| CN108619253A true CN108619253A (zh) | 2018-10-09 |
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- 2018-07-06 CN CN201810733347.5A patent/CN108619253A/zh not_active Withdrawn
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