CN108619233A - Radix scutellariae is fresh to carry vacuum drying powder decoction pieces - Google Patents

Radix scutellariae is fresh to carry vacuum drying powder decoction pieces Download PDF

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Publication number
CN108619233A
CN108619233A CN201810733265.0A CN201810733265A CN108619233A CN 108619233 A CN108619233 A CN 108619233A CN 201810733265 A CN201810733265 A CN 201810733265A CN 108619233 A CN108619233 A CN 108619233A
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CN
China
Prior art keywords
decoction
radix scutellariae
fresh
water
vacuum drying
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Withdrawn
Application number
CN201810733265.0A
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Chinese (zh)
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徐璐
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Individual
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Individual
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Priority to CN201810733265.0A priority Critical patent/CN108619233A/en
Publication of CN108619233A publication Critical patent/CN108619233A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/13Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/15Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of " radix scutellariae is fresh to carry vacuum drying powder decoction pieces ", are primarily characterized in that:Radix scutellariae harvesting after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, after extracting solution is condensed into clear cream, then be dried under vacuum to water content be less than 10%, crush, be sieved after be vacuum-packed.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter pill, powder, tablet, capsule, is conducive to carry, Clinical practice is convenient.

Description

Radix scutellariae is fresh to carry vacuum drying powder decoction pieces
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of baikal skullcap root decoction pieces.
Background technology
Baikal skullcap root is that this product is labiate radix scutellariaeScutellaria baicalensisThe dry root of Georgi, With heat-clearing and damp-drying drug, the effect of purging intense heat and detonicating, hemostasis, tocolysis.This product is mainly used for damp-warm syndrome, summer-heat and damp, chest tightness and emesis, damp and hot ruffian Full, rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, the treatment of fetal irritability etc. is tcm clinical practice Upper common a herb.The processing method of traditional radix scutellariae is:Spring, the excavation of two season of autumn, remove fibrous root and silt, are hit after solarization thick Skin dries, and is packaged, storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Such medicine materical crude slice volume is big, hygiene Standard deviation is easy to make moist, is mildew, infested, being unfavorable for taking care of, storage and transportation cost are high.In addition, such baikal skullcap root decoction pieces quality Stability is poor, and clinical efficacy is difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage Deposit/transportation cost is low, conducive to keeping, carry and easy to use, rapid-action novel baikal skullcap root decoction pieces, it is imperative.Existing market On baikal skullcap root decoction pieces, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both Using traditional medicine materical crude slice as raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes; Concentrated granular can only extract water soluble ingredient.
Invention content
The invention discloses a kind of " radix scutellariae is fresh to carry vacuum drying powder decoction pieces ", are primarily characterized in that:It is harvested in radix scutellariae Afterwards, it cleans in time, removal impurity and the dis-medicinal part such as silt, cleans in taking advantage of using fresh herb tap water in 24 hours and be cut into 2 ~ 5mm Thick piece.The piece that this cuts is added in the water of 1 ~ 5 times of 100 DEG C of weight, impregnate and is constantly stirred 5 ~ 30 minutes, filtering, the dregs of a decoction Press extracting juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, Collect concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, and being concentrated into relative density is 1.15 ~ 1.25 clear cream.The clear cream of gained is dried under vacuum to water content at 60 ~ 80 DEG C and is less than 10%, is crushed, 60 mesh sieve is crossed, Vacuum packaging is to get finished product.Finished product medicine materical crude slice content of baicalin must not be less than 10.0%.The clinical general usage amount of this baikal skullcap root decoction pieces is 1 ~ 5g can both enter decoction decoction, take after mixing it with water, also can directly enter in pill, powder, capsule and tablet, to substantially increase clinic The convenience and compliance used, is conducive to the treatment of clinical acute disease.
The present invention solve traditional baikal skullcap root decoction pieces are bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular Piece is more preferable.
Specific embodiment
It after radix scutellariae medicinal materials are harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally Water is cleaned, and is cut into the piece of 3mm thickness.This piece is added to 100 DEG C of pure water of 5 times of weight, is stirred 30 minutes, filtering, the dregs of a decoction Press extracting juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot, the dregs of a decoction are again It is secondary to squeeze the juice, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and it is 1.20 to be concentrated into relative density Clear cream.It is 8% that the clear cream of gained is dried under vacuum at 80 DEG C to water content, is crushed, and crosses 60 mesh sieve, vacuum packaging to get at Product.The content of scutelloside is 11.0% in finished product medicine materical crude slice.

Claims (2)

1. a kind of radix scutellariae is fresh to carry vacuum drying powder decoction pieces, it is primarily characterized in that:It after radix scutellariae harvesting, cleans, removes in time The impurity such as silt and dis-medicinal part are added 1 ~ 5 times in the piece for taking advantage of using fresh herb tap water in 24 hours and cleaning and being cut into 2 ~ 5mm thickness The water that 50 ~ 70 DEG C of weight is impregnated and is constantly stirred 5 ~ 30 minutes, and filtering, dregs pressing takes juice;5 ~ 10 are added in the gained dregs of a decoction The water of times weight, boils 10 ~ 30 minutes, filters while hot, and the dregs of a decoction are squeezed the juice again, collects concoction;Merge above-mentioned concoction, crosses 60 ~ 100 Mesh sieves, and is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, is concentrated into the clear cream that relative density is 1.15 ~ 1.25;By the clear cream of gained 60 ~ It is dried under vacuum to water content at 80 DEG C and is less than 10%, crushes, crosses 60 mesh sieve, is vacuum-packed to get finished product;Finished product medicine materical crude slice scutelloside Content must not be less than 10.0%.
2. radix scutellariae according to claim 1 is fresh to carry vacuum drying powder decoction pieces, it is primarily characterized in that:Clinic generally uses Amount is 1 ~ 5g, can both enter decoction decoction, take after mixing it with water, and also can directly enter in pill, powder, capsule and tablet.
CN201810733265.0A 2018-07-06 2018-07-06 Radix scutellariae is fresh to carry vacuum drying powder decoction pieces Withdrawn CN108619233A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810733265.0A CN108619233A (en) 2018-07-06 2018-07-06 Radix scutellariae is fresh to carry vacuum drying powder decoction pieces

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810733265.0A CN108619233A (en) 2018-07-06 2018-07-06 Radix scutellariae is fresh to carry vacuum drying powder decoction pieces

Publications (1)

Publication Number Publication Date
CN108619233A true CN108619233A (en) 2018-10-09

Family

ID=63688787

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810733265.0A Withdrawn CN108619233A (en) 2018-07-06 2018-07-06 Radix scutellariae is fresh to carry vacuum drying powder decoction pieces

Country Status (1)

Country Link
CN (1) CN108619233A (en)

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WW01 Invention patent application withdrawn after publication

Application publication date: 20181009

WW01 Invention patent application withdrawn after publication