CN108618977A - Oral care compound gel preparation and preparation method thereof - Google Patents
Oral care compound gel preparation and preparation method thereof Download PDFInfo
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- CN108618977A CN108618977A CN201810556326.0A CN201810556326A CN108618977A CN 108618977 A CN108618977 A CN 108618977A CN 201810556326 A CN201810556326 A CN 201810556326A CN 108618977 A CN108618977 A CN 108618977A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The present invention discloses oral care compound gel preparation and preparation method thereof；The composition of oral care compound gel preparation content by weight percentage is：The water of calcium carbonate 45% 52%, food grade sodium chloride 8.0% 10.0%, glycerine 7.0% 10.0%, bicarbonate 3.0% 5.0%, micro activated carbon particle 4.5% 5.0%, laruyl alcohol sulfuric acid ester sodium 1.5% 3.0%, chlorhexidine 1.0% 2.0%, vitamin C 0.5% 2.0%, pseudo-ginseng 0.5% 1.5%, natural plant 0.5% 2.0%, active silver ion 0.01% 0.02% and surplus.Effect：In oral care compound gel preparation provided by the present invention, contained raw material does not have toxic side effect, so that the present invention can be used as the toothpaste brushed teeth or suck the gel preparation use of chewing eaten convenient for patient, even if the present invention is eaten by mistake by patient, patient will not generate adverse reaction so that safety in utilization is good, and the present invention can effectively clean patient's mouth and kill patient's mouth germ, in turn, the present invention is highly practical, and using effect is good.
Description
Technical field
The present invention relates to oral care techniques fields, in particular, be related to a kind of oral care compound gel preparation and its
Preparation method.
Background technology
In various big hospital, for oral transmucosal intubated patient, ICU severes urgent patient, various patients after surgery and long
The sleeping patient etc. for being inconvenient to brush teeth, generally can not out-of-bed activity, so, daily life is required to come on one's sick bed
At, including wash one's face and rinse one's mouth, have a meal and defecation etc..
And for washing one's face and rinsing one's mouth, especially oral cavity after of long duration, i.e., can make patient's mouth produce when there be not cleaning-sterilizing clean
Raw peculiar smell leads to halitosis, mouth infection and forms plaque.
Traditional rule of doing is that medical staff or patient itself add toothpaste to help patient itself to brush teeth using toothbrush, is used
Although toothbrush add toothpaste come to patient brush teeth can cleaning-sterilizing patient's mouth, the toothpaste added cannot be eaten,
When angle not clock synchronization of brushing teeth, then there is the possibility that liquid of brushing teeth is eaten by patient so that patient's stomach will produce malaise symptoms, and
And medical staff or patient itself add toothpaste when patient itself being helped to brush teeth, also to seem time-consuming and laborious using toothbrush.
Thereby, it for present situation, designs and a kind of can be used as the toothpaste brushed teeth or suck eating for chewing convenient for patient
Gel preparation and the preparation method for producing the gel preparation, then be necessary.
Invention content
A kind of oral care compound gel system provided it is an object of the invention to overcome the deficiency of the above-mentioned prior art
Agent and preparation method thereof.
Technical solution is used by the present invention solves prior art problem：A kind of oral care compound gel preparation,
Forming content by weight percentage is：Calcium carbonate 45%-52%, food grade sodium chloride 8.0%-10.0%, glycerine 7.0%-
10.0%, bicarbonate 3.0%-5.0%, micro activated carbon particle 4.5%-5.0%, laruyl alcohol sulfuric acid ester sodium 1.5%-3.0%, chlorine
1.0%-2.0%, vitamin C 0.5%-2.0%, pseudo-ginseng 0.5%-1.5%, natural plant 0.5%-2.0%, activity are determined
The water of silver ion 0.01%-0.02% and surplus.
Above technical scheme is further elaborated below：
Preferably, composition content by weight percentage is：Calcium carbonate 50%, food grade sodium chloride 10.0%, glycerine
10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid ester sodium 2.0%, chlorhexidine 2.0%, vitamin
C1.0%, pseudo-ginseng 1.0%, natural plant 1.0%, active silver ion 0.02% and surplus water.
Preferably, composition content by weight percentage is：Calcium carbonate 45%, food grade sodium chloride 10.0%, glycerine
10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid ester sodium 3.0%, chlorhexidine 2.0%, vitamin
C2.0%, pseudo-ginseng 1.5%, natural plant 2.0%, active silver ion 0.02% and surplus water.
Preferably, the bicarbonate is alkali metal hydrogencarbonate, and alkali metal component is sodium and/or potassium.
Preferably, the pH value of said preparation is 7.45-7.55.
A kind of preparation method of oral care compound gel preparation, it includes the following steps：
S1, raw material preparation；
Raw material is matched by following weight percent：It is calcium carbonate 45%-52%, food grade sodium chloride 8.0%-10.0%, sweet
Oily 7.0%-10.0%, bicarbonate 3.0%-5.0%, micro activated carbon particle 4.5%-5.0%, laruyl alcohol sulfuric acid ester sodium 1.5%-
3.0%, chlorhexidine 1.0%-2.0%, vitamin C 0.5%-2.0%, pseudo-ginseng 0.5%-1.5%, natural plant 0.5%-
2.0%, active silver ion 0.01%-0.02% and the water of surplus；
S2, grinding；
By proportioned calcium carbonate, food grade sodium chloride, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid in step S1
Fat sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion are ground respectively so that its be ground into it is microgranular；
S3, stirring；
At normal temperatures and pressures, will be ground into step S2 microgranular calcium carbonate, food grade sodium chloride, bicarbonate,
Micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion are added one by one to stainless steel and stir
It is sufficiently stirred in pot, so that it is uniformly mixed；
S4, glue；
The stainless steel agitated kettle proportioned glycerine, natural plant and water in step S1 being added to one by one in step S3
In, and it is stirred respectively in its one by one adition process, so as to be ground into microgranular calcium carbonate, food-grade chlorination
Sodium, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion have dissolved
Entirely, then continue to stir 30min, so that all raw materials are uniformly mixed and form gel；
S5, ageing；
The gel that is formed by step S4 is stood for 24 hours, so as to be aged and form gel preparation.
Above technical scheme is further elaborated below：
Preferably, it further includes step：
It is S6, filling；
It is filling to the container for meeting food hygiene requirement it will to be formed by gel preparation using bottle placer；
S7, sealing；
Sealing packaging is carried out to the container of canned gel preparation using sealing machine；
S8, labeling；
According to standard and requirement is used, using labelling machine to canned gel preparation and the packaged container labeling of sealing.
Preferably, the raw material components by weight percentage in step S1 is：Calcium carbonate 50%, food grade sodium chloride
10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid ester sodium 2.0%, chlorhexidine
2.0%, the water of vitamin C 1.0%, pseudo-ginseng 1.0%, natural plant 1.0%, active silver ion 0.02% and surplus.
Preferably, the raw material components by weight percentage in step S1 is：Calcium carbonate 45%, food grade sodium chloride
10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid ester sodium 3.0%, chlorhexidine
2.0%, the water of Catergen .0%, pseudo-ginseng 1.5%, natural plant 2.0%, active silver ion 0.02% and surplus.
Preferably, the bicarbonate is alkali metal hydrogencarbonate, and alkali metal component is sodium and/or potassium；And it is prepared
Oral care compound gel preparation pH value be 7.45-7.55.
The beneficial effects of the invention are as follows：
One, a kind of oral care compound gel preparation provided by the present invention, in the specific implementation, on the one hand, contained
A certain proportion of calcium carbonate, food grade sodium chloride, glycerine, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, the chlorine having
Determined, vitamin C, pseudo-ginseng, natural plant, active silver ion and surplus water without toxic side effect so that the present invention can
The gel preparation eaten that chewing is sucked as the toothpaste brushed teeth or convenient for patient uses, even if the present invention is sick when in use
People eats by mistake, and patient will not generate adverse reaction so that safety in utilization is good and use reliability is good, on the other hand, contained
Food grade sodium chloride there is anti-inflammatory analgetic and bactericidal effect so that convenient for carrying out anti-inflammatory analgetic and sterilization, institute to patient's mouth
The micro activated carbon particle contained has the function of adsorbing patient's mouth peculiar smell that contained chlorine is so that patient's mouth keeps pure and fresh
It is fixed that also there is certain bactericidal effect so that convenient for being sterilized to patient's mouth, including vitamin C help and consolidate cell
Tissue, helps collagen synthesis, can strong patients teeth, prevent bleeding gums and gingival atrophy, including pseudo-ginseng have
Anti-inflammatory analgetic and the effect for promoting gum wound healing, including active silver ion there is safe more lasting antibacterial to make
With enable the present invention effectively to clean patient's mouth and killing patient's mouth germ as a result, so as to ensure that patient's mouth can be compared with
It keeps hygienically clean for a long time, also, in the gel preparation of the invention as convenient for patient's mouth containing chewing in use, also saving doctor
The trouble that shield personnel are brushed teeth using toothbrush addition toothpaste to patient so that medical staff's work load can be mitigated significantly, in turn,
The present invention is highly practical, and using effect is good.
Secondly, a kind of preparation method of oral care compound gel preparation provided by the present invention, process is simple and clear,
It makes it possible to greatly improve production efficiency and accelerates the production cycle, also, in the good calcium carbonate of proportioning, food grade sodium chloride, sweet
Oil, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng, natural plant, activity silver from
After son and the water of surplus, you can quick to prepare so that save manpower, in turn, the present invention necessarily has good marketing valence
Value so that can effectively be popularized.
Description of the drawings
Fig. 1 is the topological diagram of the preparation method of oral care compound gel preparation of the present invention；
Fig. 2 is the particular flow sheet of the preparation method of oral care compound gel preparation of the present invention；
The embodiments will be further described with reference to the accompanying drawings for the realization, the function and the advantages of the object of the present invention.
Specific implementation mode
Below with reference to the drawings and the specific embodiments technical solution that the present invention will be described in detail, to become apparent from, intuitively
Understand the invention essence of the present invention.
A kind of oral care compound gel preparation provided by the present invention, composition content by weight percentage are：Carbonic acid
Ca45 %-52%, food grade sodium chloride 8.0%-10.0%, glycerine 7.0%-10.0%, bicarbonate 3.0%-5.0%, work
Property carbon particle 4.5%-5.0%, laruyl alcohol sulfuric acid ester sodium 1.5%-3.0%, chlorhexidine 1.0%-2.0%, vitamin C 0.5%-
2.0%, pseudo-ginseng 0.5%-1.5%, natural plant 0.5%-2.0%, active silver ion 0.01%-0.02% and surplus
Water.
It based on described above, can define, a kind of oral care compound gel preparation provided by the present invention, then be used as mouth
Chamber care formulations use.
On the one hand, a certain proportion of calcium carbonate contained by the present invention, food grade sodium chloride, glycerine, bicarbonate, activity
Carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng, natural plant, active silver ion and surplus water do not have
Toxic side effect so that the present invention can be used as the toothpaste brushed teeth or make convenient for the gel preparation of patient's mouth containing chewing eaten
With even if the present invention is eaten by mistake by patient when in use, patient will not generate adverse reaction so that safety in utilization is good and uses
Good reliability.
On the other hand, contained food grade sodium chloride has anti-inflammatory analgetic and bactericidal effect, so that convenient for disease population
Chamber carries out anti-inflammatory analgetic and sterilization, and contained micro activated carbon particle has absorption patient's mouth peculiar smell and patient's mouth is kept
Pure and fresh effect, contained chlorhexidine also have certain bactericidal effect, so that convenient for being sterilized to patient's mouth, are wrapped
The vitamin C contained, which helps, consolidates cell tissue, helps collagen synthesis, can strong patients teeth, prevention bleeding gums and tooth
Ulatrophy, including pseudo-ginseng have the function of anti-inflammatory analgetic and promote gum wound healing, including active silver ion tool
There is safe more lasting antibacterial action, enables the present invention effectively to clean patient's mouth as a result, and kill patient's mouth
Germ, so as to ensure that the patient's mouth energy long period keeps hygienically clean.
Also, it is used as the gel preparation for sucking chewing convenient for patient in use, also saving medical staff in the present invention
The trouble that toothbrush adds toothpaste to brush teeth to patient so that medical staff's work load can be mitigated significantly.
In turn, the present invention is highly practical, and using effect is good.
Embodiment one
In the present embodiment, a kind of oral care compound gel preparation provided by the present invention, composition percentage by weight
It is than content：Calcium carbonate 50%, food grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle
5.0%, laruyl alcohol sulfuric acid ester sodium 2.0%, chlorhexidine 2.0%, vitamin C 1.0%, pseudo-ginseng 1.0%, natural plant 1.0%,
The water of active silver ion 0.02% and surplus.
Thus, it is possible to it is clear, in proportioning described above, in the present embodiment, the food grade sodium chloride, bicarbonate
Salt, micro activated carbon particle, chlorhexidine and the active silver ion are maximum proportioning so that anti-inflammatory of the present invention for patient's mouth
Analgesic and disinfection effect can be optimal.
Embodiment two
In the present embodiment, a kind of oral care compound gel preparation provided by the present invention, composition percentage by weight
It is than content：Calcium carbonate 45%, food grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle
5.0%, laruyl alcohol sulfuric acid ester sodium 3.0%, chlorhexidine 2.0%, Catergen .0%, pseudo-ginseng 1.5%, natural plant 2.0%,
The water of active silver ion 0.02% and surplus.
Thus, it is possible to it is clear, in proportioning described above, in the present embodiment, the food grade sodium chloride, bicarbonate
Salt, micro activated carbon particle, chlorhexidine and the active silver ion are being maximum proportioning so that the present invention disappears for patient's mouth
While inflammation analgesic and disinfection effect can be optimal, since the ascorbic proportioning is also maximum proportioning, thereby,
Enable the present invention preferably to consolidate patient's mouth cell tissue, more help collagen synthesis, more can strong patients teeth,
Prevent bleeding gums and gingival atrophy.
No matter be emphasized that above-described embodiment one or embodiment two, the bicarbonate is preferably then alkali metal
Bicarbonate, alkali metal component are sodium and/or potassium.
Herein, it should be noted that corresponding bicarbonate can then maintain certain meta-alkalescence, so as to slow down electuary as acid
It uses, to adjust the pH value of the present invention.
Furthermore in the specific implementation, the pH value of oral care compound gel preparation provided by the present invention is 7.45-
7.55, so as to keep alkalescent.
On the basis of described above, the present invention also provides a kind of preparation methods of oral care compound gel preparation, it is wrapped
Include following steps：
S1, raw material preparation；
Raw material is matched by following weight percent：It is calcium carbonate 45%-52%, food grade sodium chloride 8.0%-10.0%, sweet
Oily 7.0%-10.0%, bicarbonate 3.0%-5.0%, micro activated carbon particle 4.5%-5.0%, laruyl alcohol sulfuric acid ester sodium 1.5%-
3.0%, chlorhexidine 1.0%-2.0%, vitamin C 0.5%-2.0%, pseudo-ginseng 0.5%-1.5%, natural plant 0.5%-
2.0%, active silver ion 0.01%-0.02% and the water of surplus；
S2, grinding；
By proportioned calcium carbonate, food grade sodium chloride, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid in step S1
Fat sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion are ground respectively so that its be ground into it is microgranular；
S3, stirring；
At normal temperatures and pressures, will be ground into step S2 microgranular calcium carbonate, food grade sodium chloride, bicarbonate,
Micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion are added one by one to stainless steel and stir
It is sufficiently stirred in pot, so that it is uniformly mixed；
S4, glue；
The stainless steel agitated kettle proportioned glycerine, natural plant and water in step S1 being added to one by one in step S3
In, and it is stirred respectively in its one by one adition process, so as to be ground into microgranular calcium carbonate, food-grade chlorination
Sodium, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion have dissolved
Entirely, then continue to stir 30min, so that all raw materials are uniformly mixed and form gel；
S5, ageing；
The gel that is formed by step S4 is stood for 24 hours, so as to be aged and form gel preparation.
Also, after above-mentioned steps S5, the invention also includes steps：
It is S6, filling；
It is filling to the container for meeting food hygiene requirement it will to be formed by gel preparation using bottle placer；
S7, sealing；
Sealing packaging is carried out to the container of canned gel preparation using sealing machine；
S8, labeling；
According to standard and requirement is used, using labelling machine to canned gel preparation and the packaged container labeling of sealing.
Thus, it is possible to a kind of clear, preparation method of oral care compound gel preparation provided by the present invention, process
It is simple and clear so that production efficiency can be greatly improved and accelerated the production cycle, also, in the proportioning good calcium carbonate, food-grade
Sodium chloride, glycerine, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng, natural plants
After the water of glue, active silver ion and surplus, you can quick to prepare so that save manpower.
In turn, the present invention necessarily has good market popularization value so that can effectively be popularized.
You need to add is that in a kind of preferred embodiment, the raw material components by weight percentage in above-mentioned steps S1 is：Carbon
Sour calcium 50%, food grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid
Fat sodium 2.0%, chlorhexidine 2.0%, vitamin C 1.0%, pseudo-ginseng 1.0%, natural plant 1.0%, active silver ion 0.02%
And the water of surplus.
In another preferred embodiment, the raw material components by weight percentage in above-mentioned steps S1 is：Calcium carbonate 45%, food
Grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid ester sodium 3.0%,
Chlorhexidine 2.0%, Catergen .0%, pseudo-ginseng 1.5%, natural plant 2.0%, active silver ion 0.02% and surplus
Water.
Also, in above two preferred embodiment, the bicarbonate is alkali metal hydrogencarbonate, and alkali metal component is
Sodium and/or potassium, to adjust the pH value of the present invention, and the pH value of prepared oral care compound gel preparation is 7.45-7.55.
Other embodiment etc., illustrates one by one here, not doing.
In conclusion a kind of oral care compound gel preparation provided by the present invention, in the specific implementation, on the one hand,
Contained a certain proportion of calcium carbonate, food grade sodium chloride, glycerine, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid ester
Sodium, chlorhexidine, vitamin C, pseudo-ginseng, natural plant, active silver ion and surplus water without toxic side effect so that this hair
The bright gel preparation eaten that can be used as the toothpaste brushed teeth or suck chewing convenient for patient uses, even if the present invention is when in use
It is eaten by mistake by patient, patient will not generate adverse reaction so that safety in utilization is good and use reliability is good, on the other hand, institute
The food grade sodium chloride contained has anti-inflammatory analgetic and bactericidal effect, so that convenient for carrying out anti-inflammatory analgetic to patient's mouth and killing
Bacterium, contained micro activated carbon particle have the function of adsorbing patient's mouth peculiar smell and so that patient's mouth keeps pure and fresh, it is contained
Chlorhexidine also there is certain bactericidal effect so that convenient for being sterilized to patient's mouth, including vitamin C help Gong
Gu cell tissue contributes to the synthesis of collagen, the strong patients teeth of energy to prevent bleeding gums and gingival atrophy, including
Pseudo-ginseng have the function of anti-inflammatory analgetic and promote gum wound healing, including active silver ion have and safe relatively hold
Long antibacterial action makes the germ in present invention energy effective cleaning patient's mouth and killing patient's mouth as a result, so that
Ensure that the patient's mouth energy long period keeps hygienically clean, also, in the present invention as the gel system for sucking chewing convenient for patient
Agent is in use, the trouble for also saving medical staff using toothbrush addition toothpaste to brush teeth to patient so that can mitigate medical care significantly
Person works bear, and in turn, the present invention is highly practical, and using effect is good.
A kind of preparation method of oral care compound gel preparation provided by the present invention, process are simple and clear so that
Production efficiency can be greatly improved and accelerated the production cycle, also, in the proportioning good calcium carbonate, food grade sodium chloride, glycerine, carbon
Sour hydrogen salt, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng, natural plant, active silver ion and
After the water of surplus, you can quick to prepare so that save manpower, in turn, the present invention necessarily has good market popularization value, makes
Obtaining effectively to be popularized.
The foregoing is merely the preferred embodiment of the present invention, are not intended to limit the scope of patent protection of the present invention, every
Using the transformation of equivalent structure or equivalent process made by description of the invention and accompanying drawing content, it is applied directly or indirectly in it
His relevant technical field, is included within the scope of the present invention.
Claims (10)
1. a kind of oral care compound gel preparation, which is characterized in that its form content by weight percentage be：Calcium carbonate
45%-52%, food grade sodium chloride 8.0%-10.0%, glycerine 7.0%-10.0%, bicarbonate 3.0%-5.0%, activity
Carbon particle 4.5%-5.0%, laruyl alcohol sulfuric acid ester sodium 1.5%-3.0%, chlorhexidine 1.0%-2.0%, vitamin C 0.5%-
2.0%, pseudo-ginseng 0.5%-1.5%, natural plant 0.5%-2.0%, active silver ion 0.01%-0.02% and surplus
Water.
2. oral care compound gel preparation according to claim 1, which is characterized in that its composition contains by weight percentage
Amount is：Calcium carbonate 50%, food grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, the moon
Cinnamic alcohol sulfuric acid ester sodium 2.0%, chlorhexidine 2.0%, vitamin C 1.0%, pseudo-ginseng 1.0%, natural plant 1.0%, activity silver from
The water of son 0.02% and surplus.
3. oral care compound gel preparation according to claim 1, which is characterized in that its composition contains by weight percentage
Amount is：Calcium carbonate 45%, food grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%, micro activated carbon particle 5.0%, the moon
Cinnamic alcohol sulfuric acid ester sodium 3.0%, chlorhexidine 2.0%, Catergen .0%, pseudo-ginseng 1.5%, natural plant 2.0%, activity silver from
The water of son 0.02% and surplus.
4. according to claim 2-3 any one of them oral care compound gel preparations, which is characterized in that the bicarbonate
For alkali metal hydrogencarbonate, alkali metal component is sodium and/or potassium.
5. according to claim 4 any one of them oral care compound gel preparation, which is characterized in that the pH value of said preparation is
7.45-7.55。
6. a kind of preparation method of oral care compound gel preparation, which is characterized in that it includes the following steps：
S1, raw material preparation；
Raw material is matched by following weight percent：Calcium carbonate 45%-52%, food grade sodium chloride 8.0%-10.0%, glycerine
7.0%-10.0%, bicarbonate 3.0%-5.0%, micro activated carbon particle 4.5%-5.0%, laruyl alcohol sulfuric acid ester sodium 1.5%-
3.0%, chlorhexidine 1.0%-2.0%, vitamin C 0.5%-2.0%, pseudo-ginseng 0.5%-1.5%, natural plant 0.5%-
2.0%, active silver ion 0.01%-0.02% and the water of surplus.
S2, grinding；
By proportioned calcium carbonate in step S1, food grade sodium chloride, bicarbonate, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium,
Chlorhexidine, vitamin C, pseudo-ginseng and active silver ion are ground respectively so that its be ground into it is microgranular；
S3, stirring；
At normal temperatures and pressures, microgranular calcium carbonate, food grade sodium chloride, bicarbonate, activity will be ground into step S2
Carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion are added one by one into stainless steel agitated kettle
It is sufficiently stirred, so that it is uniformly mixed；
S4, glue；
Proportioned glycerine, natural plant and water in step S1 are added to one by one in the stainless steel agitated kettle in step S3,
And it is stirred respectively in its one by one adition process, so as to be ground into microgranular calcium carbonate, food grade sodium chloride, carbon
Sour hydrogen salt, micro activated carbon particle, laruyl alcohol sulfuric acid ester sodium, chlorhexidine, vitamin C, pseudo-ginseng and active silver ion dissolving are complete, then
Continue to stir 30min, so that all raw materials are uniformly mixed and form gel；
S5, ageing；
The gel that is formed by step S4 is stood for 24 hours, so as to be aged and form gel preparation.
7. the preparation method of oral care compound gel preparation according to claim 6, which is characterized in that it further includes step
Suddenly：
It is S6, filling；
It is filling to the container for meeting food hygiene requirement it will to be formed by gel preparation using bottle placer；
S7, sealing；
Sealing packaging is carried out to the container of canned gel preparation using sealing machine；
S8, labeling；
According to standard and requirement is used, using labelling machine to canned gel preparation and the packaged container labeling of sealing.
8. the preparation method of oral care compound gel preparation according to claim 7, which is characterized in that in step S1
Raw material components by weight percentage is：Calcium carbonate 50%, food grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%,
Micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid ester sodium 2.0%, chlorhexidine 2.0%, vitamin C 1.0%, pseudo-ginseng 1.0%, natural plant
The water of object glue 1.0%, active silver ion 0.02% and surplus.
9. the preparation method of oral care compound gel preparation according to claim 7, which is characterized in that in step S1
Raw material components by weight percentage is：Calcium carbonate 45%, food grade sodium chloride 10.0%, glycerine 10%, bicarbonate 5.0%,
Micro activated carbon particle 5.0%, laruyl alcohol sulfuric acid ester sodium 3.0%, chlorhexidine 2.0%, Catergen .0%, pseudo-ginseng 1.5%, natural plant
The water of object glue 2.0%, active silver ion 0.02% and surplus.
10. according to the preparation method of claim 8-9 any one of them oral care compound gel preparations, which is characterized in that
The bicarbonate is alkali metal hydrogencarbonate, and alkali metal component is sodium and/or potassium；And prepared oral care compound is solidifying
The pH value of glue preparation is 7.45-7.55.
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| CN201810556326.0A CN108618977A (en) | 2018-05-31 | 2018-05-31 | Oral care compound gel preparation and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1700905A (en) * | 2003-01-31 | 2005-11-23 | Pbl科技有限公司 | Personal care compositions with portable packs |
| JP2007091686A (en) * | 2005-09-30 | 2007-04-12 | Ltt Bio-Pharma Co Ltd | Nanoparticle containing hinokitiol |
-
2018
- 2018-05-31 CN CN201810556326.0A patent/CN108618977A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1700905A (en) * | 2003-01-31 | 2005-11-23 | Pbl科技有限公司 | Personal care compositions with portable packs |
| JP2007091686A (en) * | 2005-09-30 | 2007-04-12 | Ltt Bio-Pharma Co Ltd | Nanoparticle containing hinokitiol |
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部: "《化妆品卫生规范》", 31 January 2007 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
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