CN108617921A - A kind of lycopene preparation method cooperateing with ingredient containing pectin etc. and have repair to prostate - Google Patents
A kind of lycopene preparation method cooperateing with ingredient containing pectin etc. and have repair to prostate Download PDFInfo
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- CN108617921A CN108617921A CN201710182540.XA CN201710182540A CN108617921A CN 108617921 A CN108617921 A CN 108617921A CN 201710182540 A CN201710182540 A CN 201710182540A CN 108617921 A CN108617921 A CN 108617921A
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- lycopene
- pectin
- prostate
- catsup
- powder
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- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 title claims abstract description 93
- 235000010987 pectin Nutrition 0.000 title claims abstract description 75
- 239000001814 pectin Substances 0.000 title claims abstract description 75
- 229920001277 pectin Polymers 0.000 title claims abstract description 75
- 210000002307 prostate Anatomy 0.000 title claims abstract description 17
- 239000004615 ingredient Substances 0.000 title abstract description 10
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 230000008439 repair process Effects 0.000 title abstract description 5
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims abstract description 87
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims abstract description 87
- 229960004999 lycopene Drugs 0.000 claims abstract description 87
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- 239000001751 lycopene Substances 0.000 claims abstract description 87
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims abstract description 87
- 230000000694 effects Effects 0.000 claims abstract description 37
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- 238000000034 method Methods 0.000 claims abstract description 17
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 45
- 239000000047 product Substances 0.000 claims description 23
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 21
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 16
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/231—Pectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/40—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by drying or kilning; Subsequent reconstitution
- A23L3/44—Freeze-drying
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention discloses a kind of lycopene preparation method cooperateing with ingredient containing pectin etc. and have repair to prostate, using mixed organic solvents formulation and enzyme extraction method combination by catsup lycopene and pectin extract simultaneously, not only solve the loss of the active ingredients such as pectin in extraction process, also by pectin and lycopene relieve the effect of alcohol, the effect in terms of pre- preventing drunkenness and anti-prostate more efficiently cooperates with, combination efficacy and saferry is significantly better than single drug, plays better health-care effect in this way.The extracting method is industrially feasible, and technical process is simple, and the security performance of product is high, and yield is high.
Description
Technical field
The invention belongs to natural health care evaluation and exploration technology fields, and it is a kind of containing the collaboration ingredient such as pectin and right to be related to
Prostate has the lycopene preparation method of repair.
Background technology
Lycopene (Lycopene) is a kind of fat-soluble natural pigment, is one kind of carotenoid, is widely present in certainly
It in right boundary, is primarily present in the plants such as ripe tomato, watermelon, the careless shaddock certain kind of berries, red grape, in recent years, research is found kind
Lycopene has various biological activity, has quenching activity oxygen, eliminates human free radical, slow down atherosclerosis, prevent
Kinds cancer, relieve the effect of alcohol (patent application publication number CN104800182A disclose lycopene make invention as main component have compared with
Good antialcoholism function) and the different physiological roles such as strengthen immunity.Lycopene can not only be used for the drug or related of anticancer, anti-cancer
Health products (patent application publication number CN104800181A discloses lycopene to be enhanced as the invention of main ingredient
There is good effect in terms of prostatic function), food additives, cosmetics, food coloring etc. are also can be used as, application prospect is wide
It is general.
The average content of lycopene is 8.5mg.l00g-1 in tamato fruit, but its biological value is not high, eats a life
Tomato can only absorb the lycopene of 0.05mg, and one day tomato that need to absorb 1-2kg of adult could meet normal physiology need
It asks, the unbalanced of diet must be caused in this way.From the perspective of development, lycopene is developed very necessary at drug.And
Currently, the exploitation of lycopene Healthy relevant products has become a hot spot of functional food in the world and new drug research.
For pectin as a kind of water-soluble dietary fiber, a kind of natural plant polyose is complicated, vdiverse in function.Currently,
Raw material for producing commodity pectin is mainly citrus and apple.In addition, there is numerous studies from premna microphylla, tomato and banana
Pectin is extracted in the by-products such as skin.Pectin is a kind of to be recommended as not limited by addition by FAO/WHO food additives joint committee
The food additives of amount, due to remarkable gelation and emulsion stability as a kind of important additive in food industry
In be used as thickener, gelling agent, can be shared individually or with other excipient in pharmaceuticals industry and prepare ointment, film, suppository, micro-
The pharmaceutical preparations such as capsule.Pharmaceutical research shows that pectin has anticancer, anti diar rhea as soluble dietary fiber, relieves the effect of alcohol (2014
It is relatively good that the researchs such as Li quintessences have shown that pectin has the function of in terms of relieving the effect of alcohol with pre- preventing drunkenness), treatment diabetes and other effects.More
Carry out the anticancer effect that target diversion is studied pectin by more scholars, it is found that pectin can be used as internal galectin-3
(Galectin-3) competitive inhibitor of ligand, preventing the formation of tumour, (researchs such as Lu Sheng people in 2012 have shown that fruit with development
Glue has the effect of that prostate gland cancer cell is inhibited to be proliferated well).China's research antitumor about pectin starts from 2005, main
Concentrate on the effect aspect of citrus low molecule pectin and ginseng pectin to tumour.Foreign countries are about antitumor seminar master
Concentrate on the U.S. and Japan, the U.S. in 1993 just about the antitumor patent of low molecule pectin, it is external in the past 20 years to close
Made rapid progress is achieved in the antitumor research of pectin, has large size pharmacy corporation and is applied to pectin to prepare targeting anti-tumor medicine
Object space face, wherein pectin adriamycin have been enter into preclinical phase.
Currently, the raw material of lycopene is mainly derived from tomato, the raw material of pectin is mainly derived from citrus and apple.This
Outside, some researches show that tomato is equally applied to as the source of pectin in the research of extracting method, and result of study is shown kind
Pectin content in eggplant is up to 0.72%.
Invention content
The purpose of the present invention is the above-mentioned deficiencies for the prior art, provide a kind of containing the collaboration ingredient such as pectin and to preceding
Row gland has the lycopene preparation method of repair.
What the present invention was achieved through the following technical solutions.
A kind of extracting method of the lycopene containing pectin, includes the following steps：
(1) fresh tomato, cleaning plus water are weighed, 100 DEG C of heat preservation 15min is heated to, smashs into catsup after being rinsed with water to pieces；
(2) it is added mixed solvent into catsup, the solid-liquid ratio of catsup and mixed solvent is 1：2.0~4.0, wherein
The mixed solvent is made of the aqueous solution of acid in ethyl acetate, and the volume ratio of sour aqueous solution and ethyl acetate is 1：0.5
~1.5；
(3) between the pH 2.0~3 for adjusting (2) solution, then biological enzyme is added into system, is heated to 40~60 DEG C, enzyme
For solution after 3~5 hours, the catsup liquid handled carries out Microwave Extraction, is filtered by vacuum after extraction, and filtrate is collected, and retains
Filter residue；
(4) filter residue ethyl acetate, sour aqueous solution filter after extracting successively, merge with filtrate in (3)；
(5) filtrate, the lycopene powder product for being freeze-dried containing pectin are concentrated.
Wherein in step (1), 2~4 times of the preferred tomato weight of water weight of addition.
In step (2), the preferred hydrochloric acid of acid, and a concentration of 0.2mol/L of the aqueous acid medium of acid.
In step (3), Microwave Extraction time preferably 10~35min, ultrasonic power 100-200W.
The mass ratio of pectin and lycopene is in the lycopene powder product containing pectin：1：1~
100。
The pectous lycopene prepared according to above-mentioned extracting method.
Pectous lycopene of the present invention is preparing anti-prostate cancer, is improving male prostate symptom, prevention
The drunk application in the health products to relieve the effect of alcohol.
A kind of to improve male prostate function, the health products that relieve the effect of alcohol, it is characterised in that containing of the present invention containing pectin
Lycopene.
Advantageous effect：
Lycopene powder containing pectin composition made of of the invention, had both remained the healthcare functions such as lycopene, had
There are anti-oxidant, anticancer, anti-aging, relieve the effect of alcohol and the effects that pre- preventing drunkenness；The healthcare function for also supplementing pectin simultaneously has anti-
The effects that diarrhea, anticancer, treatment diabetes.Wherein lycopene and pectin, which all have, relieves the effect of alcohol, before pre- preventing drunkenness and prevention
The function of row parathyrine cancer, and the present invention is made lycopene powder and contains pectin and lycopene simultaneously, the two ingredients are total to
With in the presence of collaboration improve human body relieve the effect of alcohol, pre- preventing drunkenness and the ability for preventing prostaglandin cancer etc..Extract tomato red
Pectin with synergy is proposed to have many advantages, such as to reduce extraction cost while plain, it is easy to operate；Using vacuum refrigeration
This dry physical method is dried, and reduces chemical contamination；The method of the present invention is simple, and the course of work is easily operated；The present invention
Raw material sources are extensive, cheap, and production cost is low, and working condition is mild, and environmental pollution is small.
Specific implementation mode
The invention will be further described by the following examples.
Embodiment 1
Fresh tomato 500g is weighed, is positioned in beaker after washing with water, the water of 2 times of tomato weight is added, is heated to 100
DEG C heat preservation 15min, smash into catsup after being rinsed with water to pieces.Mixed solvent is added into catsup (i.e. containing ethyl acetate
The aqueous solution of 0.2mol/L hydrochloric acid), the wherein aqueous solution of hydrochloric acid：Ethyl acetate=1：0.5 (V/V), catsup and mixed solvent
Solid-liquid ratio be 1：2.0(g/mL)；Between the pH 2.0 for adjusting solution, then protease is added into system, heating temperature 50
DEG C, enzymolysis is after 3 hours, and processing obtains catsup liquid input microwave device, and (it is public that day wawter bloom justifies pharmaceutical equipment science and technology Limited Liability
Department) it extracts, microwave mixing time is 10min, and ultrasonic power 150W is filtered by vacuum after extraction, collects filtrate, is protected
Stay filter residue；Filter residue ethyl acetate, sour aqueous solution filter after extracting successively, merge with above-mentioned gained filtrate；Filtrate is concentrated, it is cold
Be lyophilized it is dry, weigh lycopene powder 40g, HPLC method to measure wherein lycopene content be 28g, pectin content is
3.7g。
Embodiment 2
Fresh tomato 1Kg is weighed, is positioned in beaker after washing with water, the water of 3 times of tomato weight is added, is heated to 100
DEG C heat preservation 15min, smash into catsup after being rinsed with water to pieces.Mixed solvent is added into catsup (i.e. containing ethyl acetate
The aqueous solution of 0.2mol/L hydrochloric acid), the wherein aqueous solution of hydrochloric acid：Ethyl acetate=1：1 (V/V), catsup and mixed solvent
Solid-liquid ratio is 1：3.0(g/mL)；Between the pH 2.5 for adjusting solution, then protease being added into system, heating temperature is 40 DEG C,
Enzymolysis 4 hours after, processing obtain catsup liquid input microwave device (Huayuan Pharmaceutical Equipment Science ＆ Technology Co., Ltd., Tianshui) into
Row extraction, microwave mixing time are 30min, and ultrasonic power 100W is filtered by vacuum after extraction, collect filtrate, retain filter
Slag；Filter residue ethyl acetate, sour aqueous solution filter after extracting successively, merge with above-mentioned gained filtrate；Filtrate is concentrated, freezing is dry
Dry, weighing obtains lycopene powder 0.13Kg, HPLC method and measures wherein lycopene content to be 0.094Kg, and pectin contains
Amount is 12.1g.
Embodiment 3
Fresh tomato 10Kg is weighed, is positioned in beaker after washing with water, the water of 4 times of tomato weight is added, is heated to 100
DEG C heat preservation 15min, smash into catsup after being rinsed with water to pieces.Mixed solvent is added into catsup (i.e. containing ethyl acetate
The aqueous solution of 0.2mol/L hydrochloric acid), the wherein aqueous solution of hydrochloric acid：Ethyl acetate=1：1.5 (V/V), catsup and mixed solvent
Solid-liquid ratio be 1：4.0(g/mL)；Between the pH 3.0 for adjusting solution, then protease is added into system, heating temperature 60
DEG C, enzymolysis is after 5 hours, and processing obtains catsup liquid input microwave device, and (it is public that day wawter bloom justifies pharmaceutical equipment science and technology Limited Liability
Department) it extracts, microwave mixing time is 20min, and ultrasonic power 200W is filtered by vacuum after extraction, collects filtrate, is protected
Stay filter residue；Filter residue ethyl acetate, sour aqueous solution filter after extracting successively, merge with above-mentioned gained filtrate；Filtrate is concentrated, it is cold
Be lyophilized it is dry, weighing obtain lycopene powder 1.44Kg, HPLC method and measure lycopene content wherein in powder be
1.24Kg, pectin content 139.8g.
The lycopene of ingredient is cooperateed with to have containing pectin below by way of being further illustrated the present invention to specific test of pesticide effectiveness example
There is prostatic function.
Embodiment 4
Anti-prostate cancer cell in vivo studies
1, materials and methods
1.1 sample
The lycopene powder that ingredient is cooperateed with containing pectin of the present invention；Pure lycopene powder identical as content of the present invention
End；Pure pectin powder identical as content of the present invention.
1.2 cell
Human prostata cancer PC3 cells are purchased from Chinese Academy of Sciences's Shanghai cell bank
The selection of 1.3 dosage
The lycopene powder of embodiment 3, pure lycopene powder, pure pectin powder are prepared as sample with DMSO (AR)
The solution example of product, each powder is as follows：
Lycopene powder (a of embodiment 31)：10309ug/mL、5155ug/mL、2557ug/mL、1031ug/mL；
Pure lycopene powder (a2)：8876ug/mL、4438ug/mL、2202ug/mL、888ug/mL；
Pure pectin powder (a3)：1000ug/mL、500ug/mL、250ug/mL、100ug/mL；
2, test method
By the good human prostata cancer PC3 cell dissociations of growth conditions, human prostata cancer PC3 cell suspensions are obtained, and carry out
Cell concentration is adjusted to 1 × 10 by cell count according to counting5A/mL；According to the volume in the holes 180uL/ by a concentration of 1 × 105
The human prostata cancer PC3 cell suspension inoculations of a/mL are cultivated for 24 hours in 96 orifice plates in 5%CO2,37 DEG C of cell incubators；
The solution example of tri- kinds of powder of 20uL is added in 96 orifice plates again, three multiple holes are arranged in each concentration gradient, are averaged, with not
The blanc cell culture medium of dosing is blank control group.In 5%CO2, cultivate for 24 hours in 37 DEG C of cell incubators；5 are added per hole
Mg/mL MTT solution 10uL, are placed in 4h in incubator, abandon supernatant, and the holes DMSO 100uL/ are added, and concussion 15min makes purple
Crystallization is completely dissolved, and 96 orifice plates are placed in microplate reader, selects wavelength for 570nm, measures OD values.
3, calculation formula
Human prostata cancer PC3 cell inhibitory rates (%)=OD0-ODJ/OD0
ODJFor the absorbance of test group (dosing)；
OD0For the absorbance of normal group (not dosing).
4, statistical procedures use SPSS statistical packages, data to be indicated with x ± s.One-way analysis of variance, group difference
It is examined using t.
5, result
As shown in Table 1, using the cell that is not loaded as blank control, when sample amount pure lycopene under four concentration
Ability with certain inhibition human prostata cancer PC3 cell Proliferations, inhibiting rate reaches 50% or more, and certain agent is presented
Measure dependence.And the lycopene powder (a of embodiment 31) in high dose (P=is significantly stronger than to the inhibiting effect of cancer cell
0.0213<0.05, with a2Compare) as the pure lycopene (a of sample amount2)。
As shown in Table 2, using the cell that is not loaded as blank control, when the pure pectin of sample amount all has under four concentration
The ability of certain inhibition human prostata cancer PC3 cell Proliferations, and certain dose dependent is presented.And the tomato of embodiment 3
Red pigment powder (a1) in high dose to the inhibiting effect of cancer cell compared with the pure pectin (a when sample amount3) extremely significantly increase (P=
0.003<0.01, with a3Compare).
3 sample a in Tables 1 and 21、a2、a3It shows that human prostata cancer PC3 cells is inhibited to increase under doses
The ability grown, and the inhibiting effect of a1 is greater than single a2 or a3.
Table 1 is when sample amount lycopene is to human prostata cancer PC3 cell inhibitory rates
*P<0.05, * * P<0.01
Table 2 is when sample amount pectin is to human prostata cancer PC3 cell inhibitory rates
*P<0.05, * * P<0.01
Embodiment 5 improves mouse prostate hyperplasia, the pre- preventing drunkenness of mouse and mouse and relieves the effect of alcohol experiment
One, improve mouse prostate Proliferation Assays
1.1 sample
The lycopene powder that ingredient is cooperateed with containing pectin of the present invention；Pure lycopene powder identical with content of the present invention
End；Pure pectin powder identical with content of the present invention.
1.2 experimental animal
ICR male mices 60,18~22g of weight (animal cards number：SCXK (Shanghai) 2007-0005)
The selection of 1.3 dosage
The lycopene powder of embodiment 3, pure lycopene powder, pure pectin powder are made with physiological saline (pH7.0)
Standby is sample, and the solution example of each powder is as follows：
Lycopene powder (the b of embodiment 31)：3000mg/kg、1000mg/kg、500mg/kg、200mg/kg；
Pure lycopene powder (b2)：2583mg/kg、861mg/kg、430.5mg/kg、232.3mg/kg；
Pure pectin powder (b3)：291.3mg/kg、97.1mg/kg、48.55mg/kg、19.42mg/kg；
1.4 method
Mouse 65 is only randomly divided into 13 groups, 13 groups of Normal group 1 and experiment.Mouse routinely forage feed one week
Afterwards, in addition to Normal group, testosterone propionate is subcutaneously injected according to 5mg/kg daily in remaining mouse, and (Shanghai GM medicine company share is limited
Company produces, lot number 070102) modeling, while remaining 12 groups of gavage gives drug 1 time, continuous 21d.Last time administration is for 24 hours
Afterwards, it is put to death after each group animal being weighed, wins prostate and claim weight in wet base, calculate prostate index, prostate index=prostate is wet
Weight (mg)/mouse weight (g).It takes blood in cleaned glass test tube through arteria carotis communis, stands overnight, next day takes serum, by kit
(being purchased from Beijing North Institute of Biological Technology) operating instruction, detects testosterone (T) and estradiol (E in prostate2) horizontal.
1.5 result
By table 3 and table 4 it is found that compared with Normal group, T and E in model group rats prostata tissue2It is horizontal significantly to rise
Height makes rat prostate group hyperplasia occur under exogenous androgenic effect.Compared with model group, when the lycopene of sample amount
(b2) or pectin (b3) T and E in four dosage the following groups can reduce rat model prostate2It is horizontal.The tomato red of embodiment 3
Plain powder (b1) in high dose compared with the lycopene (b when sample amount2) it can extremely significantly decrease T and E in rat model2It is horizontal
(P=0.0078 or 0.0092<0.01, with b2Compare), and relatively work as the pectin (b of sample amount3) although rat model can be reduced
Middle T and E2Level, but the not notable (P=0.147 or 0.221 of otherness>0.05 and b3Compare).3 samples in table 3 and table 4
Product b1、b2、b3It can inhibit the mouse prostate hyperplasia induced by testosterone propionate under doses, it is equal to hyperplasia of prostate
There is certain therapeutic effect.
Table 3, the T and E in sample amount lycopene is to mouse prostate weight in wet base and serum2Influence
(*P<0.05, * * P<0.01)
Table 4, the T and E in sample amount pectin is to mouse prostate weight in wet base and serum2Influence
(*P<0.05, * * P<0.01)
Two, the pre- preventing drunkenness of mouse and experiment of relieving the effect of alcohol
2.1 sample
The lycopene powder that ingredient is cooperateed with containing pectin of the present invention；Pure lycopene powder identical with content of the present invention
End；Pure pectin powder identical with content of the present invention.
2.2 experimental animal
ICR mouse 100 (half male and half females), 18~22g of weight (animal cards number：SCXK (Shanghai) 2007-0005)
The selection of 2.3 dosage
Lycopene powder (the c of embodiment 31)：116mg、290mg、580mg；
Pure lycopene powder (c2)：100mg、250mg、500mg；
Pure pectin powder (c3)：11.3mg、28.2mg、56.6mg.
Gavage volume is the product suspension per 100g mouse weights 1.5mL (1.5mL/100g).Solvent is 1%CMNa.
The pre- preventing drunkenness experiment of 2.4 mouse
Mouse 50 is only randomly divided into 10 groups, 91 group of control, experiment groups.Fasting 1 night (12h) before experiment.Each group is distinguished
Gavage 1.5mL/100g 1%CMNa, the lycopene powder of embodiment 3, pure lycopene powder, pure pectin powder 30min
Afterwards.Each group is gavaged with 52 ° of Red Star Erguotou wines with 1.5mL/100g weight.The drunk rate of mouse is observed and recorded, and is observed small
The death rate in mouse 24 hours.The activity condition for observing mouse, being creeped with mouse, unstable, rear abdomen mops floor, hair is loose, closing one's eyes is ignorant of
For drunk index.With activity freely, flexibly, spirit, hair it is smooth to sober up index.
The 2.5 mouse test mice 50 that relieves the effect of alcohol only is randomly divided into 10 groups, 91 group of control, experiment groups.1 night of fasting before experiment
(12h).Each group is gavaged with 52 ° of Red Star Erguotou wines with 1.5mL/100g weight.After 30min is all drunk, except control group uses
Gavage 1%CMNa, remaining 3 groups of difference gavage 1.5mL/100g 1%CMNa, the lycopene powder of embodiment 3, pure tomato red
Plain powder, pure pectin powder.Relieving the effect of alcohol the time for mouse is observed and recorded, and observes the dead number of elements of mouse in for 24 hours.
2.6 experimental result
2.6.1 the pre- preventing drunkenness test result of mouse
By table 5 and table 6 it is found that compared with Normal group, the lycopene powder (c of embodiment 31), pure lycopene
Powder (c2), pure pectin powder (c3) there is apparent pre- preventing drunkenness effect at the highest dose, and certain dose-dependant is presented
Property (compared with normal group).
Table 5 compares drunk effect when sample amount lycopene
(*P<0.05, * * P<0.01)
Table 6 compares drunk effect when sample amount pectin
(*P<0.05, * * P<0.01)
The test result 2.6.2 mouse is relieved the effect of alcohol
By table 7 and table 8 it is found that compared with Normal group, the lycopene powder (c of embodiment 31), pure lycopene
Powder (c2), pure pectin powder (c3) under three dosage there is dispelling effects of alcohol, as the increase of sample concentration time of sobering up becomes
It is short, and certain dose dependent is presented.The time of relieving the effect of alcohol in high dose of the lycopene powder of embodiment 3 is considerably shorter than pure
Lycopene powder or pure pectin powder (P=0.0217<0.05, with c2Compare；P=0.0412<0.05, with c3)。
Table 7 is when sample amount lycopene is to sober up effect comparison sheet
*P<0.05, * * P<0.01
Table 8 is when sample amount pectin is to sober up effect comparison sheet
*P<0.05, * * P<0.01
Embodiment 6 improves male prostate symptom and male and relieves the effect of alcohol experiment
One, improve the experiment of male prostate symptom
60 hyperplasia of prostate middle-aging male (cardinal symptoms confirmed through hospital：Average urination 8~10 times daily, put down
Get up in the night to urinate number 2~4 times, and with urodynamic sense), it is divided into 3 groups, every group is divided into 20 people；First group, continuously take the present invention
3 product of embodiment, 3 lycopene powder dose of embodiment 23.2mg/ days, 60 days；Second group：Continuously take and embodiment 3
The pure lycopene product of equal volume, pure lycopene dose 20mg/ days, 60 days；Third group：It is continuous to take and embodiment
The pure pectin powder product of 3 equal volumes, pure lycopene dose 2.3mg/ days, 60 days.
Test result shows as follows：As shown in Table 9：The lycopene or pectin phase of product of the present invention and single component
Than middle-aging male isuria frequency, number of averagely getting up in the night to urinate are substantially reduced, and antalgesic state is substantially reduced, and illustrates this hair
Bright lycopene powder has better effect in terms of improving male prostate symptom.
Table 9 improves male prostate symptomatic consequence comparison sheet
Two, human body liver-protecting and alcoholism-relieving is tested
The male female volunteers of 30 health of subject, are randomly divided into 3 groups, every group of 10 people；First group, take the production of embodiment 3
Product lycopene powder (55.8mg)；Second group, the pure lycopene (48mg) with 3 equal volume of embodiment；Third group, with reality
Apply the pure pectin (5.4mg) of 3 equal volume of example；Indigo plant 42 ° of 100~300mL of white wine that the above volunteer drinks Yanghe River sea are differed, and half
After hour, there is phenomena such as different degrees of facial flushes in three groups of volunteers, have part dysequilibrium, dizziness, language occur
The drunk symptom such as unclear, respectively warm water takes product lycopene powder of the present invention, tomato to the one two three group of volunteer immediately
Red pigment, pectin, pay a return visit volunteer and continue to observe at the case where observing and recording volunteer after 30min, 60min, 90min afterwards for 24 hours.
Experimental result：As shown in Table 10, product of the present invention is compared with the lycopene of single component or pectin, 30min
Afterwards, three groups of volunteer's septum resets are rubescent, the symptoms such as drunk are mitigated or disappeared；3 product lycopene of embodiment after 60min
The drunk aspiration disease 80% of powder group restores normal, and pure lycopene group is 70%；3 product lycopene of embodiment after 120min
The drunk aspiration disease of powder group is restored normally, and pure lycopene group 90% restores normal, and pure pectin group 60% restores normal.24h
After pay a return visit volunteer, the one or two group of phenomena such as not being still drank after a night, volunteer's night does not occur reaction of having a stomach upset, and sleep is good
Good, third group occurs sleeping slightly weaker phenomenon.The above result shows that product of the present invention compared with single component lycopene or
Person's pectin has the effect of stronger liver-protecting and alcoholism-relieving.
Table 10, human body dispelling effects of alcohol compare
Claims (8)
1. a kind of extracting method of the lycopene containing pectin, it is characterised in that include the following steps：
(1) fresh tomato is weighed, water is added after cleaning, 100 DEG C of heat preservation 15min is heated to, smashs into catsup after being rinsed with water to pieces；
(2) it is added mixed solvent into catsup, the solid-liquid ratio of catsup and mixed solvent is 1：2.0~4.0, wherein described
Mixed solvent be made of in ethyl acetate the aqueous solution of acid, the volume ratio of sour aqueous solution and ethyl acetate is 1：0.5~
1.5；
(3) pH of (2) solution is adjusted to 2.0~3, then biological enzyme is added into system, is heated to 40~60 DEG C, enzymolysis 3~5 is small
Shi Hou, the catsup liquid handled carry out Microwave Extraction, are filtered by vacuum after extraction, collect filtrate, retain filter residue；
(4) filter residue ethyl acetate, sour aqueous solution filter after extracting successively, and filtrate merges with filtrate in (3)；
(5) filtrate, the lycopene powder product for being freeze-dried containing pectin are concentrated.
2. extracting method according to claim 1, it is characterised in that：In step (1), the water weight of addition is tomato weight
2~4 times.
3. extracting method according to claim 1, it is characterised in that in step (2), acid is hydrochloric acid, and in the aqueous solution of acid
A concentration of 0.2mol/L of acid.
4. extracting method according to claim 1, it is characterised in that：The Microwave Extraction time is 10~35min, ultrasonic power
For 100-200W.
5. extracting method according to claim 1, it is characterised in that：The lycopene powder product containing pectin
The mass ratio of middle pectin and lycopene is 1：1~100.
6. the pectous lycopene prepared according to the extracting method described in any one of claim 1-5.
7. the pectous lycopene described in claim 6 is preparing anti-prostate cancer, is improving male prostate symptom, prevention
The drunk application in the health products to relieve the effect of alcohol.
8. a kind of to improve male prostate function, the health products that relieve the effect of alcohol, it is characterised in that containing containing pectin described in claim 6
Lycopene.
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