CN108607057A - Relieving cough and asthma particle of a kind of small infantile paralysis dragon and preparation method thereof - Google Patents
Relieving cough and asthma particle of a kind of small infantile paralysis dragon and preparation method thereof Download PDFInfo
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- CN108607057A CN108607057A CN201810561075.5A CN201810561075A CN108607057A CN 108607057 A CN108607057 A CN 108607057A CN 201810561075 A CN201810561075 A CN 201810561075A CN 108607057 A CN108607057 A CN 108607057A
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Abstract
The invention discloses relieving cough and asthma particles of a kind of small infantile paralysis dragon and preparation method thereof, by the stir-fry semen armeniacae amarae of numb imperial cough-relieving, stir-baked SEMEN PERSICAE, prepared RHIZOMA PINELLIZE without adju-vant, Radix Glycyrrhizae, gypsum medicinal material adds water to extract, Chinese ephedra, earthworm, Fructus Forsythiae, the root bark of white mulberry, the sweet tuber of stemona, the root of purple-flowered peucedanum, loguat leaf medicinal material adds ethyl alcohol to extract, merge gained extracting solution, the relieving cough and asthma extraction cream powder of small infantile paralysis dragon is made after drying is concentrated under reduced pressure, obtained cream powder is arranged in pairs or groups with suitable auxiliary material, the root of purple-flowered peucedanum of the obtained relieving cough and asthma particle of small infantile paralysis dragon, loguat leaf, the discriminating Xiang Jun of earthworm meets relevant regulations, Active Ingredients of Forsythia Suspensa content is high, it is in good taste simultaneously, convenient for being taken as children's medicine.
Description
Technical field
The present invention relates to field of pharmaceutical preparations, and in particular to relieving cough and asthma particle of a kind of small infantile paralysis dragon and preparation method thereof.
Background technology
Chronic cough after upper sense refers to cough secondary after the infection of the upper respiratory tract, and symptom is obstinate, and protracted course of disease shows as battle array more
The cough of hair property is very, after by cold wind and penetrating odor easily to break out with night, and phlegm is not easy expectoration less.
Exogenous cough has the various virulence factors of diseases caused by external factors to invade, also have constitution lung itself to defend not solid, phlegm is turbid, perennial root, mistake
The internal factors such as quick.Some patients, especially children often suffer from nocturnal cough, and extremely mostly is asthma, but patient has no asthma in the daytime
Symptom, therefore be not easy to find for doctor, if when being produced immediate results mostly with treating asthma.
Small infantile paralysis dragon is relieving cough and asthma, and particle can be relieving cough and reducing sputum, and the antiallergy that can relieving asthma is exactly the jinx of this kind of illness, and eight
Taste collaboration has asthma then to relieving asthma, and cough is then controlled in no asthma, just shows the feature of we.Zhisou San is exactly originally cough-relieving good recipe, and forefathers praise it highly
" have eliminating the phlegm, dredge lung, cough-relieving ideal work(, nothing opens the door to invite thieves and stays the disadvantage of heresy." to exogenous cough's best results, ideal, side
Just, effective, inexpensive.All fever and chills, which are biased to not acute person, to be substantially square with Zhisou San.Function：Clearing lung and eliminating phlegm, expelling wind and cold pathogens, sending down abnormally ascending stop
Cough.It cures mainly：For being known as phlegm heat, chill is felt again, strongly fragrant and change heat, combination of phlegm and heat, lung loses that a surname is respectful, mechanism of qi superinverse and the cough repeatedly that causes
It coughs, more so phlegm glued difficulty and coughed up, nasal congestion etc., allergic cough sees above-mentioned symptom person night.
Modern pharmacological research result：Low concentration ephedrine or pseudoephedrine in Chinese ephedra are responsible for bronchiectasis, right
The bronchial dilating effect of contraction state is more notable, can alleviate the dog resistance of respiratory tract caused by histamine or acetylcholine and increase
Add；Ephedrine has central antitussive effect, has relexation to bronchial smooth muscle, therefore can relieving asthma.
90% alcohol-extracted extract of wide dragon has significant bronchorelaxing activity, the hypoxanthine contained in earthworm, succinic acid
Energy diastole bronchus, and to bronchoconstriction caused by antihistamine and pilocarpine, pilocarpinum, its discharge is made to increase by 2
~3 times or more；The a variety of amino acid proposed from earthworm also have spasmolysis of relievining asthma through guinea pig tissues amine spray testing proof.
Semen armeniacae amarae, peach kernel decompose the micro hydrogen cyanide of generation in vivo, will not cause to be poisoned, and in calm respiratory center
Effect.The root of purple-flowered peucedanum can obviously increase the amount of respiratory secretions, illustrate have phlegm to act on, and long action time.Fructus Forsythiae may have
The release of anti-allergic effects, sensitized guinea pig lung sections Anaphylactic mediator under antigenic stimulus can be because of 1 × 10-3g/ of Fructus Forsythiae ethanol extract
Ml and significantly reduce.
Dried pinellia, pinellia, ginger soaks decoction 0.6-1g/kg gavages or the intravenous injection of the tuber of pinellia and the alum tuber of pinellia, to cat iodine
The cough that liquid injects caused by thoracic cavity or electro photoluminescence superior laryngeal nerve has apparent antitussive effect, can maintain 5 hours or more.Alum water
The mixed liquor of the tuber of pinellia also has apparent antitussive action, effect to be slightly better than health product and old method product.The health product of the tuber of pinellia and RHIZOMA TYPHONII FLAGELLIFORMIS and it is new,
The alcohol medicinal extract of old method product gives intragastric administration on mice, and new, the old method product for measuring the tuber of pinellia and RHIZOMA TYPHONII FLAGELLIFORMIS with phenol red method has apparent eliminating the phlegm to make
With.
Loguat leaf ingredient amygdalin can be decomposed gradually in alimentary canal and generate micro hydrogen cyanide, but be unlikely to draw
Body poisoning is played, and certain antitussive effect is presented；This product decoction and ethyl acetate extract have eliminating the phlegm, antiasthmatic effect, oil
Lipid also has slight phlegm-dispelling functions.The root bark of white mulberry has slight antitussive effect.The glycyrrhizic acid of 0.46mmol/L concentration can inhibit histamine
Mast cell degranulation caused by releasing agent-compound 48/80, to prevent the release of Anaphylactic mediator；Radix Glycyrrhizae can also promote
Throat and bronchial secretion make sputum be easy expectoration, and eliminating phlegm and relieving cough effect is presented.
Tropical China medicine supplementary issue of volume 2 in 2002 reports numb imperial cough-relieving soup and controls 84 observation of curative effect-of exogenous cough i.e.
Numb dragon cough-relieving is from quasi- side, and by Chinese ephedra, earthworm, Radix Glycyrrhizae, dried orange peel, the tuber of stemona, aster, campanulaceae, Cynanchum glaucescens, totally 8 herbal medicines form substantially
Side, cures mainly various exogenous coughs.By 84 clinical treatment observations, effective 52, effective 21, invalid 11, total effective rate
86.9%.It is convenient, inexpensive, effective, suitable for people of all ages to have the characteristics that.
Exogenous cough is caused by diseases caused by external factors ailment said due to cold or exposure is to advocate peace the Different types of etiopathogenises such as internal injury.In October, 1999 in October, 2000,
From the quasi- imperial cough-relieving side of fiber crops, in outpatient service by expecting example clinical treatment observation, effective 52, effective 21, invalid 1, total effective rate
86.90%.It is convenient, effective, suitable for people of all ages that we have the characteristics that, adapts to social area masses' needs of medical treatment.
Application No. is 201410040365.7 Chinese invention patents to disclose a kind of Malong cough relieving granule and its preparation side
Method, by relieving cough and asthma 1 part of the extraction cream powder of numb dragon, 1 part~100 parts of filler, 0.2 part~15 parts of thickener, 0.3 part of adhesive~
10 parts, 0.1 part~8 parts corrigents are made；The relieving cough and asthma extraction cream powder of the fiber crops dragon is by proposing the grouping of 12 taste medicinal materials plus water
Take it is obtained, the relieving cough and asthma particle of obtained fiber crops dragon dissolve in water it is rapid, form clear solution in good taste, convenient for taking
With bioavilability is high.All medicinal materials are extracted with water for the invention, can influence having for the root of purple-flowered peucedanum in product, loguat leaf and earthworm
Effective component content causes the root of purple-flowered peucedanum, loguat leaf and the active constituent content of earthworm relatively low and unstable.
Invention content
The object of the present invention is to provide a kind of relieving cough and asthma of small infantile paralysis dragons quality controllable, active constituent content is high
The preparation method of grain, improves the root of purple-flowered peucedanum in product, loguat leaf, the active constituent content of earthworm and stability so that before in product
Recklessly, loguat leaf, earthworm discriminating Xiang Jun meet relevant regulations, while also improving the content of Forsythoside in product.
A kind of preparation method of the relieving cough and asthma particle of small infantile paralysis dragon, includes the following steps：
(1) will fry semen armeniacae amarae, stir-baked SEMEN PERSICAE, prepared RHIZOMA PINELLIZE without adju-vant, Radix Glycyrrhizae, the gypsum five tastes, extracting in water 2 times, 1~3 hour every time,
The dosage of first time water is 5~15 times of gomi herbs total weight, and the dosage of second of water is the 3~14 of gomi herbs total weight
Times, merge the extracting solution obtained twice, filter, is concentrated under reduced pressure, it is cooling, it is slowly added to ethyl alcohol under agitation to solution containing alcohol
Amount is 65%~85%, stands 24 hours, leaching supernatant obtains extracting solution A；
(2) by Chinese ephedra, earthworm, Fructus Forsythiae, the root bark of white mulberry, the sweet tuber of stemona, the root of purple-flowered peucedanum, seven taste of loguat leaf, with a concentration of 55%~80%
Ethyl alcohol extract 2 times, ethanol consumption is all 4~14 times of seven flavor medicine material total weight twice, is flowed back 0.5~3 hour every time, filtering
Extracting solution merges, obtains extracting solution B；
(3) extracting solution A and extracting solution B are merged, is concentrated under reduced pressure to give concentrate；Gained concentrate is dried under reduced pressure again,
The relieving cough and asthma extraction cream powder of small infantile paralysis dragon is made；
(4) the relieving cough and asthma extraction cream powder of small infantile paralysis dragon that step (3) obtains is uniformly mixed with filler and corrigent
It to mixture, adds adhesive and softwood is made, for softwood after granulation, it is flat to obtain the small infantile paralysis dragon cough-relieving for dry, whole grain
Breathe heavily particle；
Wherein, the parts by weight of each medicinal material are as follows：
Fry 1~3 part of semen armeniacae amarae, 1~3 part of stir-baked SEMEN PERSICAE, 2~4 parts of prepared RHIZOMA PINELLIZE without adju-vant, 1~2 part of Radix Glycyrrhizae, 4~9 parts of gypsum, Chinese ephedra
1~2 part, 1~3 part of earthworm, 1~3 part of Fructus Forsythiae, 1~3 part of the root bark of white mulberry, sweet 1~3 part of the tuber of stemona, 1~3 part of the root of purple-flowered peucedanum, loguat leaf 2~4
Part；
The parts by weight of each raw material are as follows in step (4)：
Imperial relieving cough and asthma 1 part of the extraction cream powder of small infantile paralysis, 1~50 part of filler, 0.05~5 part of corrigent, adhesive 0.2~
5 parts.
The root of purple-flowered peucedanum can obviously increase the amount of respiratory secretions, illustrate have phlegm to act on, and long action time.Contained by loguat leaf
Ingredient amygdalin can be decomposed gradually in alimentary canal and generate micro hydrogen cyanide, but be unlikely to that body is caused to be poisoned, and be presented one
Fixed antitussive effect；This product decoction and ethyl acetate extract have eliminating the phlegm, antiasthmatic effect, grease matter also to have slight eliminating the phlegm to make
With.90% alcohol-extracted extract of wide dragon has significant bronchorelaxing activity, the hypoxanthine contained in earthworm, succinic acid energy diastole
Bronchus, and to bronchoconstriction caused by antihistamine and pilocarpine, pilocarpinum, make its discharge increase by 2~3 times with
On；The a variety of amino acid proposed from earthworm also have spasmolysis of relievining asthma through guinea pig tissues amine spray testing proof.
Based on the plurality of advantages more than root of purple-flowered peucedanum, loguat leaf, earthworm, the present invention is directed to and medicinal material is only extracted with water in the prior art
The relatively low and unstable problem of this three tastes medicinal material content of the root of purple-flowered peucedanum, loguat leaf and earthworm in caused product is selected 12 tastes
Medicinal material according to every respective characteristic of taste medicinal material with different solvents carry out again grouping extract, wherein fry semen armeniacae amarae, stir-baked SEMEN PERSICAE,
Prepared RHIZOMA PINELLIZE without adju-vant, Radix Glycyrrhizae, the gypsum five tastes add water to extract, and Chinese ephedra, earthworm, Fructus Forsythiae, the root bark of white mulberry, the sweet tuber of stemona, the root of purple-flowered peucedanum, loguat leaf
Seven tastes then add ethyl alcohol to extract.
When the root of purple-flowered peucedanum, loguat leaf, earthworm are extracted with ethyl alcohol, in products obtained therefrom the active constituent content of this three tastes medicinal material it is high and
Stablize；But when being extracted with water, the active constituent content of three taste medicinal material of this in products obtained therefrom is relatively low and unstable, therefore of the invention
Method improves the root of purple-flowered peucedanum in product, loguat leaf, the active constituent content of earthworm and stability so that the root of purple-flowered peucedanum in product, loguat leaf,
The discriminating Xiang Jun of earthworm meets relevant regulations.
Chinese ephedra then be using ethyl alcohol extraction recovery rate compared with water extract it is slightly higher, therefore Chinese ephedra using ethyl alcohol extract, Chinese ephedra and
Stir-fry semen armeniacae amarae, stir-baked SEMEN PERSICAE, which close, to be decocted, and on amarogentin content without influence, but ephedrine total amount slightly has difference.
Fructus Forsythiae has anti-inflammatory and anti-allergic effects, and Forsythoside is the principle active component in Folium Forsythia, by Forsythoside
Study on extraction show：The content of Forsythoside is relatively low and unstable in products obtained therefrom when being extracted with water, but when tight
Lattice control ethanol consumption, and the content of Forsythoside is obviously improved than before in products obtained therefrom after being extracted 2 times with ethyl alcohol, this is
Due to that active ingredient Forsythoside can be promoted to be fully dissolved out with ethyl alcohol extraction.
It is used on the contrary, frying the recovery rate ratio that semen armeniacae amarae, stir-baked SEMEN PERSICAE, Radix Glycyrrhizae and gypsum are then active ingredient when being extracted with water
It is high when ethyl alcohol extracts, and prepared RHIZOMA PINELLIZE without adju-vant is then that can just reduce its toxicity due to being only extracted with water.
Preferably, the temperature being concentrated under reduced pressure in step (1) is 60 DEG C~85 DEG C, and vacuum degree is 0.01MPa~0.08MPa,
Be concentrated into relative density be 1.05~1.35 concentrate, this be in order to ensure the active ingredient in concentration process in product not by
Loss.
Preferably, the temperature being concentrated under reduced pressure in step (3) is 65 DEG C~85 DEG C, vacuum degree 0.01MPa~0.08MPa, dense
It is reduced to the concentrate that relative density is 1.15~1.35, this does not suffer a loss also for active ingredient in guarantee concentration process, contracts
Short production cycle, further in order to ensure subsequently to differentiate that item meets relevant regulations.
Preferably, the filler in the step (4) is in glucose, sucrose, mannitol, fructose, dextrin, sodium cyclamate
Arbitrary two kinds, this is that the water content based on the relieving cough and asthma extraction cream powder of small infantile paralysis dragon is high, hygroscopicity is relatively strong, easily caking, flowing
Property difference feature, auxiliary material need to be added to improve its physical characteristic, prepared granule quality is made more to stablize, is reliable, ensure
Grain forming is preferable, and mobility, melting are preferable, facilitate patients, and is suitable for large-scale production.
Further preferably, the filler in step (4) be cane sugar powder and dextrin, may further ensure that gained particle at
Type, mobility and melting.
Preferably, the corrigent in step (4) is arbitrary three in citric acid, sodium cyclamate, aspartame, stevioside
Kind, this is because this product is children, therefore mouthfeel is very crucial, only with the sugariness of cane sugar powder far from the hardship for covering Chinese medicine
Taste can reach best mouthfeel at this time so three kinds of corrigents of selection.
Preferably, the ethyl alcohol that the adhesive in step (4) is a concentration of 75%~90%, this is to ensure pelletizing forming
Property is higher, and particle color and luster obtained and hardness are moderate.
Preferably, in step (4), drying temperature is 40 DEG C~70 DEG C, and drying time is 6h~10h, is to make effectively
Ingredient is not destroyed, and ensure that the Fructus Forsythiae content of the ultimate yield of product, the moisture of product and product.
Preferably, in step (4), the small relieving cough and asthma grain diameter for extracting cream powder, filler and corrigent of infantile paralysis dragon is equal
No more than 80 mesh, its purpose is to particle uneven colors one caused by avoiding granularity excessive.
The present invention also provides the relieving cough and asthma particles of the small infantile paralysis being prepared by above method dragon.
Crude drug of the present invention is described in detail below：
Raw ephedra：Pungent, slight bitter, temperature, return lung, bladder warp, have expelling wind and cold pathogens, open the inhibited lung-energy work(, for treat block of lung-QI,obstruction of lung-QI
The key medicine of cough and asthma.
Earthworm：It is salty, cold, the benefits of Return liver, spleen, bladder warp have heat-clearing dredging collateral, and spasmolysis is relievingd asthma.Two medicines share, clearing heat and freeing lung,
Expelling wind and cold pathogens, stopping nausea and vomiting by lowering the adverse flow of QI.
Semen armeniacae amarae：Bitter, tepor, return lung, large intestine channel, sending down abnormally ascending is relieving cough and asthma.
The tuber of stemona：Pungent, bitter, tepor, distributed in lung channel, moistening lung to lower qi cough-relieving.
Loguat leaf：Hardship is slightly cold, and attaches to the lung and stomach meridians, removing heat from the lung to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.
Prepared RHIZOMA PINELLIZE without adju-vant：It is acrid in flavour and warm in nature, returns spleen, stomach, lung channel, eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI.Four medicines share, and work(stops in sending down abnormally ascending dissolving phlegm
Cough, coughing for new chronic cough has good effect, is altogether ministerial drug.
Gypsum：It in sweet, pungent, Great Cold, attaches to the lung and stomach meridians, clearing heat-fire；
Fructus Forsythiae：Hardship is slightly cold, return lung, the heart, small intestinl channel, clearing heat and detoxicating, dispelling wind and heat from the body；
The root bark of white mulberry：It is sweet, cold, distributed in lung channel, clear purging the lung of pathogenic fire heat, depressing Qi and relieving asthma；
The root of purple-flowered peucedanum：It is pungent, bitter, be slightly cold, distributed in lung channel, lowering the adverse-rising QI to resolve phlegm, relieve heat heat-clearing.Four medicines belong to cold and cool product, have both helped earthworm clear
Purging the lung of pathogenic fire heat, and Chinese ephedra can be helped to dredge table, the property of its warm is helped, is all ministerial drug, adjutant.
Peach kernel：Bitter, sweet, flat, the thoughts of returning home, liver, large intestine channel, promoting blood circulation relax bowel, relieving cough and asthma, except reinforcement ministerial drug apricot
Benevolence it is relieving cough and asthma the benefits of outside, live the stasis of blood effect also help prevention impairment of dispersing and descending function of the lung, disorder of qi generate blood stasis as；
Licorice：Sweet, flat, the thoughts of returning home, lung, spleen, stomach have the effect of clearing heat and detoxicating, expelling phlegm and arresting coughing, coordinating the drug actions of a prescription.Two medicines
It is all that assistant is allowed to product.
Compared with prior art, the present invention having the advantages that：
(1) 12 taste medicinal materials are divided into two groups by the method for the present invention again according to every respective characteristic of taste medicinal material, with water and second
Alcohol extracts twice respectively, while the dosage of stringent control water and ethyl alcohol, the root of purple-flowered peucedanum in the obtained relieving cough and asthma particle of small infantile paralysis dragon,
The discriminating of loguat leaf and earthworm meets relevant regulations, while also improving the active constituent content of Fructus Forsythiae in product；
(2) the method for the present invention has selected three kinds of corrigents to be used together, and can reach best mouthfeel at this time, meet children's dress
Specific demand of the used time to mouthfeel；
(3) the method for the present invention is easy to operate, is not necessarily to any special installation, and at low cost, high income is suitble to industrialized production.
Specific implementation mode
Embodiment 1
(1) semen armeniacae amarae 330g, stir-baked SEMEN PERSICAE 360g, prepared RHIZOMA PINELLIZE without adju-vant 380g, Radix Glycyrrhizae 210g, the gypsum 1110g five tastes will be fried, water is added
Extraction 2 times, 1.5 hours every time, for the first time plus 8 times of amount water, second plus 6 times of amount water merged extracting solution, filtration is in temperature
60 DEG C, vacuum degree is concentrated under reduced pressure into relative density under the conditions of being 0.08MPa be 1.10, cooling, is slowly added under agitation
Ethyl alcohol to solution alcohol content is 75%, stands 24 hours, leaching supernatant obtains extracting solution A；
(2) by Chinese ephedra 220g, earthworm 260g, Fructus Forsythiae 330g, root bark of white mulberry 340g, sweet tuber of stemona 310g, root of purple-flowered peucedanum 330g, loguat leaf
Seven tastes of 380g are extracted 2 times with 65% ethyl alcohol, add 10 times of amount ethyl alcohol for the first time, and for the second time plus 8 times of amount ethyl alcohol, each reflux 1 are small
When, extracting solution filtration merges, obtains extracting solution B；
(3) extracting solution A and extracting solution B are merged, is stood, be 65 DEG C in temperature, depressurized under the conditions of vacuum degree 0.03MPa dense
Contracting obtains the concentrate that relative density is 1.15；Gained concentrate is dried under reduced pressure again, the relieving cough and asthma extraction of small infantile paralysis dragon is made
Cream powder 396g；
(4) the relieving cough and asthma extraction cream powder of small infantile paralysis dragon and cane sugar powder are crossed into 80 sieves, it is spare；Small infantile paralysis dragon relieving cough and asthma is carried
Take cream powder 396g, cane sugar powder 345g, dextrin 241g, citric acid 20g, sodium cyclamate 8g, aspartame 4g are mixed
Object is closed, softwood is made in 75% ethyl alcohol for adding 62g, and dry 8h obtains particle at 60 DEG C, is distributed into 6g/ bags, totally 167 bags.
Embodiment 2
(1) semen armeniacae amarae 220g, stir-baked SEMEN PERSICAE 320g, prepared RHIZOMA PINELLIZE without adju-vant 240g, Radix Glycyrrhizae 250g, the gypsum 1090g five tastes will be fried, water is added
Extraction 2 times, 1.5 hours every time, for the first time plus 9 times of amount water, second plus 7 times of amount water merged extracting solution, filtration is in temperature
70 DEG C, vacuum degree is concentrated under reduced pressure into relative density under the conditions of being 0.05MPa be 1.10, cooling, is slowly added under agitation
Ethyl alcohol to solution alcohol content is 80%, stands 24 hours, leaching supernatant obtains extracting solution A；
(2) by Chinese ephedra 280g, earthworm 160g, Fructus Forsythiae 360g, root bark of white mulberry 200g, sweet tuber of stemona 250g, root of purple-flowered peucedanum 290g, loguat leaf
Seven tastes of 270g are extracted 2 times with 65% ethyl alcohol, add 12 times of amount ethyl alcohol for the first time, and for the second time plus 10 times of amount ethyl alcohol, each reflux 1 are small
When, extracting solution filtration merges, obtains extracting solution B；
(3) extracting solution A and extracting solution B are merged, is stood, be 80 DEG C in temperature, depressurized under the conditions of vacuum degree 0.05MPa dense
Contracting obtains the concentrate that relative density is 1.35；Gained concentrate is dried under reduced pressure again, the relieving cough and asthma extraction of small infantile paralysis dragon is made
Cream powder 380g；
(4) the relieving cough and asthma extraction cream powder of small infantile paralysis dragon and cane sugar powder are crossed into 80 sieves, it is spare；Small infantile paralysis dragon relieving cough and asthma is carried
Take cream powder 380g, cane sugar powder 405g, dextrin 201g, citric acid 20g, sodium cyclamate 9g, aspartame 9g are mixed
Object is closed, softwood is made in 80% ethyl alcohol for adding 53g, and dry 6h obtains particle at 70 DEG C, is distributed into 6g/ bags, totally 169 bags.
Embodiment 3
(1) semen armeniacae amarae 280g, stir-baked SEMEN PERSICAE 380g, prepared RHIZOMA PINELLIZE without adju-vant 310g, Radix Glycyrrhizae 180g, the gypsum 1130g five tastes will be fried, water is added
Extraction 2 times, for the first time plus 9 times are measured water, are extracted 1.5 hours；Second plus 7 times of amount water, are extracted 2 hours, extracting solution merges, filter
It crosses, is 85 DEG C in temperature, vacuum degree is concentrated under reduced pressure into relative density under conditions of being 0.06MPa be 1.20, cooling, in stirring bar
It is 80% that ethyl alcohol to solution alcohol content is slowly added under part, stands 24 hours, leaching supernatant obtains extracting solution A；
(2) by Chinese ephedra 200g, earthworm 260g, Fructus Forsythiae 310g, root bark of white mulberry 380g, sweet tuber of stemona 340g, root of purple-flowered peucedanum 190g, loguat leaf
Seven tastes of 320g are extracted 2 times with 65% ethyl alcohol, add 12 times of amount ethyl alcohol for the first time, and for the second time plus 10 times of amount ethyl alcohol, each reflux 1 are small
When, extracting solution filtration merges, obtains extracting solution B；
(3) extracting solution A and extracting solution B are merged, is stood, be 70 DEG C in temperature, depressurized under the conditions of vacuum degree 0.06MPa dense
Contracting obtains the concentrate that relative density is 1.31；Gained concentrate is dried under reduced pressure again, the relieving cough and asthma extraction of small infantile paralysis dragon is made
Cream powder 408g；
(4) the relieving cough and asthma extraction cream powder of small infantile paralysis dragon and cane sugar powder are crossed into 80 sieves, it is spare；Small infantile paralysis dragon relieving cough and asthma is carried
Take cream powder 408g, cane sugar powder 350g, dextrin 180g, citric acid 40g, sodium cyclamate 20g, aspartame 6g are mixed
Object is closed, softwood is made in 80% ethyl alcohol for adding 58g, and dry 8h obtains particle at 60 DEG C, is distributed into 6g/ bags, totally 164 bags.
Embodiment 4
(1) semen armeniacae amarae 350g, stir-baked SEMEN PERSICAE 370g, prepared RHIZOMA PINELLIZE without adju-vant 290g, Radix Glycyrrhizae 220g, the gypsum 1150g five tastes will be fried, water is added
Extraction 2 times, for the first time plus 10 times are measured water, are extracted 1.5 hours；Second plus 8 times of amount water, are extracted 2 hours, extracting solution merges, filter
It crosses, is 65 DEG C in temperature, vacuum degree is concentrated under reduced pressure into relative density under the conditions of being 0.04MPa be 1.10, cooling, in stirring condition
Under be slowly added to ethyl alcohol to solution alcohol content be 85%, stand 24 hours, leaching supernatant obtains extracting solution A；
(2) by Chinese ephedra 240g, earthworm 280g, Fructus Forsythiae 270g, root bark of white mulberry 350g, sweet tuber of stemona 310g, root of purple-flowered peucedanum 210g, loguat leaf
Seven tastes of 300g are extracted 2 times with 75% ethyl alcohol, add 14 times of amount ethyl alcohol for the first time, and for the second time plus 12 times of amount ethyl alcohol, each reflux 1 are small
When, extracting solution filtration merges, obtains extracting solution B；
(3) extracting solution A and extracting solution B are merged, is stood, be 80 DEG C in temperature, depressurized under the conditions of vacuum degree 0.05MPa dense
Contracting obtains the concentrate that relative density is 1.30；Gained concentrate is dried under reduced pressure again, the relieving cough and asthma extraction of small infantile paralysis dragon is made
Cream powder 412g；
(4) the relieving cough and asthma extraction cream powder of small infantile paralysis dragon and cane sugar powder are crossed into 80 sieves, it is spare；Small infantile paralysis dragon relieving cough and asthma is carried
Take cream powder 412g, cane sugar powder 360g, dextrin 190g, citric acid 16g, sodium cyclamate 7g, aspartame 7g are mixed
Object is closed, softwood is made in 90% ethyl alcohol for adding 59g, and dry 10h obtains particle at 40 DEG C, is distributed into 6g/ bags, totally 163 bags.
Comparative example 1
(1) by Chinese ephedra 220g, stir-fry semen armeniacae amarae 330g, stir-baked SEMEN PERSICAE 360g, root of purple-flowered peucedanum 330g, sweet tuber of stemona 310g, Fructus Forsythiae 330g six
Taste, extracting in water 2 times, 1.5 hours every time, for the first time plus 8 times were measured water, and second plus 6 times of amount water merge extracting solution, filter,
Temperature is 60 DEG C, and vacuum degree is concentrated under reduced pressure into relative density under the conditions of being 0.08MPa be 1.10, cooling, stands 24 hours, leaching
Supernatant obtains extracting solution A；
(2) by earthworm 260g, prepared RHIZOMA PINELLIZE without adju-vant 380g, loguat leaf 380g, root bark of white mulberry 340g, gypsum 1110g, Radix Glycyrrhizae 210g six
Taste, extracting in water 2 times, 1 hour every time, for the first time plus 10 times were measured water, and second plus 8 times of amount water, extracting solution filtration, merging obtain
To extracting solution B；
(3) extracting solution A and extracting solution B are merged, is stood, be 65 DEG C in temperature, depressurized under the conditions of vacuum degree 0.03MPa dense
Contracting obtains the concentrate that relative density is 1.15；Gained concentrate is dried under reduced pressure again, the relieving cough and asthma extraction cream powder of fiber crops dragon is made
382g；
(4) the relieving cough and asthma extraction cream powder of small infantile paralysis dragon and cane sugar powder are crossed into 80 sieves, it is spare；By the numb relieving cough and asthma extraction cream of dragon
Powder 382g, cane sugar powder 345g, dextrin 241g, aspartame 4g, which are uniformly mixed, obtains mixture, adds the 75% ethyl alcohol system of 62g
At softwood, dry 8h obtains particle at 60 DEG C, is distributed into 6g/ bags, totally 160 bags.
Comparative example 2
(1) by Chinese ephedra 300g, stir-fry semen armeniacae amarae 500g, peach kernel 500g, root of purple-flowered peucedanum 500g, sweet tuber of stemona 500g, Fructus Forsythiae 500g, dosing
After the boiling boiling of 6 times of amounts of material weight, in 60 DEG C, temperature leaching 3 times, 2 hours every time, the warm immersion liquid of merging was spare, and the dregs of a decoction discard, spare；
(2) by earthworm 400g, prepared RHIZOMA PINELLIZE without adju-vant 600g, loguat leaf 600g, root bark of white mulberry 500g, gypsum 1800g, Radix Glycyrrhizae 300g,
After the boiling boiling of 6 times of amounts of dosing material weight, in 50 DEG C, temperature leaching 3 times, 2 hours every time, the warm immersion liquid of merging was spare, and the dregs of a decoction discard, standby
With；
(3) (1) and (2) extracting solution is merged, is stood, filtration, filtrate low pressure concentrates (vacuum degree 0.05MPa, temperature 55
DEG C, concentrate relative density be 1.125), it is spare；
(4) concentrate obtained by (3) is spray-dried (under conditions of 120 DEG C of inlet air temperature, 90 DEG C of leaving air temp), be made
Numb dragon cough-relieving extract medicinal powder 486g.
Numb imperial cough-relieving extraction cream powder, HPMC K4M are crossed into 80 mesh sieve respectively, sucrose smashes it through 80 sieves, spare.
Numb imperial cough-relieving extraction cream powder 486g, HPMC K4M 98g, stevioside 50g are mixed
Object, by 2 addition said mixtures of Sucrose, each addition is sucrose 7290g, and it is mixed to be both needed to mixing after addition sucrose every time
It is even, be then added 1% polyvinylpyrrolidone, 50% ethanol water 243g be made softwood (wherein, 1% be made be polyethylene pyrrole
The volume ratio of the mass concentration of pyrrolidone, the solvent that 50% ethanol water refers to is 1: 1), in 60 DEG C~80 DEG C dryings after granulation, doing
Dry 2 hours, whole grain, packing obtained Malong cough relieving granule.
Comparative example 3
(1) by Chinese ephedra 360g, stir-fry semen armeniacae amarae 530g, peach kernel 530g, root of purple-flowered peucedanum 530g, sweet tuber of stemona 530g, Fructus Forsythiae 530g, dosing
After the boiling boiling of 8 times of amounts of material weight, in 65 DEG C, temperature leaching 3 times, 2 hours every time, the warm immersion liquid of merging was spare, and the dregs of a decoction discard, spare；
(2) by earthworm 430g, prepared RHIZOMA PINELLIZE without adju-vant 610g, loguat leaf 610g, root bark of white mulberry 530g, gypsum 1820g, Radix Glycyrrhizae 360g,
After the boiling boiling of 8 times of amounts of dosing material weight, in 60 DEG C, temperature leaching 3 times, 2 hours every time, the warm immersion liquid of merging was spare, and the dregs of a decoction discard, standby
With；
(3) (1) and (2) extracting solution is merged, is stood, filtration, filtrate low pressure concentrates (vacuum degree 0.04MPa, temperature 55
DEG C, concentrate relative density be 1.15), it is spare；
(4) concentrate obtained by (3) is spray-dried (under conditions of 165 DEG C of inlet air temperature, 120 DEG C of leaving air temp), system
Obtain numb imperial cough-relieving extract medicinal powder 492g.
Numb imperial cough-relieving extraction cream powder, HPMC K4M are crossed into 80 mesh sieve respectively, sucrose smashes it through 80 sieves, spare.
Numb imperial cough-relieving extraction cream powder 492g, HPMC K4M 102g, lychee flavor 56g are mixed
Conjunction object, by 2 addition said mixtures of lactose point, each addition is lactose 7740g, and it is mixed to be both needed to mixing after addition lactose every time
Even, softwood is made in the 50% ethanol water solution 252g that 2% polyethylene glycol is then added, and in 75 DEG C of dryings after granulation, does
Dry 3.5 hours, whole grain, packing obtained Malong cough relieving granule.
By Examples 1 to 4 and comparative example 1~3, the relieving cough and asthma particle of fiber crops dragon obtained presses Chinese Pharmacopoeia version in 2015 respectively
Four ruless of preparations and one progress quality inspection, about the root of purple-flowered peucedanum, loguat leaf, earthworm identification experiment in, observe test sample
Chromatography is on position corresponding with control medicinal material chromatography, if show apparent homochromy spot, it is apparent homochromy when showing
Spot meets regulation, and on the contrary then against regulation, specific inspection result is as shown in the table：
As seen from table, the root of purple-flowered peucedanum, loguat leaf and the mirror of earthworm in the relieving cough and asthma particle of small infantile paralysis dragon that Examples 1 to 4 obtains
Other Xiang Jun meets regulation, illustrates that the root of purple-flowered peucedanum in products obtained therefrom, loguat leaf and the active constituent content of earthworm are stablized, active ingredient carries
Take rate height；In addition, the active constituent content of Fructus Forsythiae is also very high in product, mouthfeel is fine.But the numb dragon that comparative example 1~3 obtains is stopped
The root of purple-flowered peucedanum, loguat leaf and the discriminating of earthworm item have part against regulation in cough particle, illustrate the root of purple-flowered peucedanum in products obtained therefrom, loguat leaf and
The active constituent content of earthworm is unstable；In addition, the active constituent content of Fructus Forsythiae is relatively low in product.
Claims (10)
1. a kind of preparation method of the relieving cough and asthma particle of small infantile paralysis dragon, includes the following steps：
(1) will fry semen armeniacae amarae, stir-baked SEMEN PERSICAE, prepared RHIZOMA PINELLIZE without adju-vant, Radix Glycyrrhizae, the gypsum five tastes, extracting in water 2 times, 1~3 hour every time, first
The dosage of secondary water is 5~15 times of gomi herbs total weight, and the dosage of second of water is 3~14 times of gomi herbs total weight,
Merge the extracting solution obtained twice, filter, is concentrated under reduced pressure, it is cooling, it is slowly added to ethyl alcohol under agitation to solution alcohol content
It is 65%~85%, stands 24 hours, leaching supernatant obtains extracting solution A；
(2) by Chinese ephedra, earthworm, Fructus Forsythiae, the root bark of white mulberry, the sweet tuber of stemona, the root of purple-flowered peucedanum, seven taste of loguat leaf, with a concentration of 55%~80% second
Alcohol extracting 2 times, ethanol consumption is all 4~14 times of seven flavor medicine material total weight twice, is flowed back 0.5~3 hour every time, filtering extraction
Liquid merges, obtains extracting solution B；
(3) extracting solution A and extracting solution B are merged, is concentrated under reduced pressure to give concentrate；Gained concentrate is dried under reduced pressure again, is made
The relieving cough and asthma extraction cream powder of small infantile paralysis dragon；
(4) the relieving cough and asthma extraction cream powder of small infantile paralysis dragon that step (3) obtains is uniformly mixed with filler and corrigent and is mixed
Object is closed, adhesive is added and softwood is made, softwood is after granulation, dry, whole grain, obtains relieving cough and asthma of the small infantile paralysis dragon
Grain；
Wherein, the parts by weight of each medicinal material are as follows：
Fry 1~3 part of semen armeniacae amarae, 1~3 part of stir-baked SEMEN PERSICAE, 2~4 parts of prepared RHIZOMA PINELLIZE without adju-vant, 1~2 part of Radix Glycyrrhizae, 4~9 parts of gypsum, Chinese ephedra 1~2
Part, 1~3 part of earthworm, 1~3 part of Fructus Forsythiae, 1~3 part of the root bark of white mulberry, sweet 1~3 part of the tuber of stemona, 1~3 part of the root of purple-flowered peucedanum, 2~4 parts of loguat leaf；
The parts by weight of each raw material are as follows in step (4)：
Imperial relieving cough and asthma 1 part of the extraction cream powder of small infantile paralysis, 1~50 part of filler, 0.05~5 part of corrigent, 0.2~5 part of adhesive.
2. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(1) in, the temperature of reduced pressure is 60 DEG C~85 DEG C, and vacuum degree is 0.01MPa~0.08MPa, and being concentrated into relative density is
1.05~1.35 concentrate.
3. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(3) in, the temperature of reduced pressure is 65 DEG C~85 DEG C, vacuum degree 0.01MPa~0.08MPa, and it is 1.15 to be concentrated into relative density
~1.35.
4. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(4) filler in is arbitrary two kinds in glucose, cane sugar powder, mannitol, fructose, dextrin, sodium cyclamate.
5. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(4) filler in is cane sugar powder and dextrin.
6. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(4) corrigent in is arbitrary three kinds in citric acid, sodium cyclamate, aspartame, stevioside.
7. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(4) ethyl alcohol that the adhesive in is a concentration of 75%~90%.
8. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(4) in, drying temperature is 40 DEG C~70 DEG C, and drying time is 6h~10h.
9. the preparation method of the relieving cough and asthma particle of small infantile paralysis dragon according to claim 1, which is characterized in that the step
(4) in, the small relieving cough and asthma grain diameter for extracting cream powder, filler and corrigent of infantile paralysis dragon is no more than 80 mesh.
10. a kind of relieving cough and asthma particle of small infantile paralysis dragon, which is characterized in that the side described in any one of claim 1~9 claim
Method is prepared.
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| CN114224849A (en) * | 2022-01-26 | 2022-03-25 | 北京东方运嘉科技发展有限公司 | Suhuang cough relieving granules for children and preparation method thereof |
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| CN114224849A (en) * | 2022-01-26 | 2022-03-25 | 北京东方运嘉科技发展有限公司 | Suhuang cough relieving granules for children and preparation method thereof |
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