CN108606956A - 用于治疗唾液酸缺乏的方法和制剂 - Google Patents
用于治疗唾液酸缺乏的方法和制剂 Download PDFInfo
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- CN108606956A CN108606956A CN201810170704.1A CN201810170704A CN108606956A CN 108606956 A CN108606956 A CN 108606956A CN 201810170704 A CN201810170704 A CN 201810170704A CN 108606956 A CN108606956 A CN 108606956A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US61/363,995 | 2010-07-13 | ||
| CN2011800439776A CN103370069A (zh) | 2010-07-13 | 2011-07-13 | 用于治疗唾液酸缺乏的方法和制剂 |
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| CN2011800439776A Pending CN103370069A (zh) | 2010-07-13 | 2011-07-13 | 用于治疗唾液酸缺乏的方法和制剂 |
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| EP (1) | EP2593109A4 (https=) |
| JP (1) | JP5777712B2 (https=) |
| KR (1) | KR20140003380A (https=) |
| CN (2) | CN108606956A (https=) |
| AU (1) | AU2011279158B2 (https=) |
| BR (1) | BR112013000776A2 (https=) |
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| WO (1) | WO2012009474A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110548012A (zh) * | 2019-08-27 | 2019-12-10 | 嘉必优生物技术（武汉）股份有限公司 | 一种唾液酸片剂及其制备方法 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| CA2805222A1 (en) | 2010-07-13 | 2012-01-19 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| HK1201067A1 (en) | 2011-10-24 | 2015-08-21 | 罕见病药物研发公司 | Sialic acid analogs |
| CA2862836A1 (en) * | 2012-01-18 | 2013-07-25 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| US20140057856A1 (en) * | 2012-08-22 | 2014-02-27 | The Regents Of The Universtiy Of California | Compositions and Methods For Enhancing Sialic Acid Levels In Tissue |
| IL313511A (en) | 2014-11-12 | 2024-08-01 | Seagen Inc | Compounds acting on glycans and methods of using them |
| US10385085B2 (en) | 2015-09-14 | 2019-08-20 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
| EP3373969A4 (en) | 2015-11-12 | 2019-08-14 | Siamab Therapeutics, Inc. | GLYCANINTERAGING COMPOUNDS AND METHOD OF USE |
| EP3541847A4 (en) | 2016-11-17 | 2020-07-08 | Seattle Genetics, Inc. | COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE |
| KR102653141B1 (ko) | 2017-03-03 | 2024-04-01 | 씨젠 인크. | 글리칸-상호작용 화합물 및 사용 방법 |
| US11348013B2 (en) * | 2017-10-31 | 2022-05-31 | Vie Technologies Inc. | Determining, encoding, and transmission of classification variables at end-device for remote monitoring |
| EP3486326A1 (en) | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Method for the purification of n-acetylneuraminic acid from a fermentation broth |
| US20200371110A1 (en) * | 2018-01-12 | 2020-11-26 | The Wistar Institute Of Anatomy And Biology | Methods for identifying and treating hiv persistence |
| CN121793948A (zh) * | 2023-09-01 | 2026-04-03 | 豪夫迈·罗氏有限公司 | 用于制备半固体组合物的新颖方法及其用途 |
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| US20100159001A1 (en) * | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6168418A (ja) | 1984-09-11 | 1986-04-08 | Kanto Ishi Pharma Co Ltd | 去痰薬 |
| EP0820305A2 (en) | 1995-04-04 | 1998-01-28 | Wound Healing of Oklahoma | Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| WO1999052931A1 (fr) | 1998-04-10 | 1999-10-21 | Mitsubishi Chemical Corporation | Dispersion solide contenant un derive d'acide sialique |
| RU2362807C2 (ru) * | 2002-06-21 | 2009-07-27 | Ново Нордиск Хелт Кэр Аг | Конъюгат полипептида фактора vii, способ его получения, его применение и содержащая его фармацевтическая композиция |
| US7238677B2 (en) * | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
| US20050201974A1 (en) | 2003-12-09 | 2005-09-15 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| WO2006096161A1 (en) * | 2005-03-03 | 2006-09-14 | Mannatech, Inc. | Methods and compositions for modified release of nutritional supplements |
| WO2007103286A2 (en) | 2006-03-02 | 2007-09-13 | Spherics, Inc. | Rate-controlled bioadhesive oral dosage formulations |
| WO2008027557A2 (en) | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| EP2155207A2 (en) | 2007-05-31 | 2010-02-24 | Government Of The United States Of America As Represented by Secretary of the Dep. of Health and Human Services National Institute of Health | N-acetyl mannosamine as a therapeutic agent |
| WO2009032605A2 (en) * | 2007-08-27 | 2009-03-12 | Massachusetts Institute Of Technology | Bi-functional polymer-attached inhibitors of influenza virus |
| CN102316730A (zh) | 2008-05-09 | 2012-01-11 | 天雅瑞药业有限公司 | 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释 |
| KR101116864B1 (ko) * | 2008-08-01 | 2012-02-29 | 주식회사 베네비오 | 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물 |
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| US20100160363A1 (en) | 2008-12-19 | 2010-06-24 | Aaipharma Services Corp. | Extended-release pharmaceutical formulations |
| CN102427817B (zh) | 2009-05-15 | 2015-02-11 | 财团法人日本健康科学振兴财团 | 起因于gne蛋白质功能降低的疾病的治疗用药物、食品组合物、食品添加剂 |
| CA2805222A1 (en) | 2010-07-13 | 2012-01-19 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| HK1201067A1 (en) | 2011-10-24 | 2015-08-21 | 罕见病药物研发公司 | Sialic acid analogs |
| CA2862836A1 (en) | 2012-01-18 | 2013-07-25 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
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2011
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- 2011-07-13 WO PCT/US2011/043910 patent/WO2012009474A1/en not_active Ceased
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- 2011-07-13 EP EP11807478.0A patent/EP2593109A4/en not_active Withdrawn
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- 2011-07-13 US US13/810,068 patent/US9511015B2/en active Active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100159001A1 (en) * | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
Non-Patent Citations (1)
| Title |
|---|
| MAY CHRISTINE V MALICDAN 等: "Prophylactic treatment with sialic acid metabolites precludes the development of the myopathic phenotype in the DMRV-hIBM mouse model", 《NATURE MEDICINE》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110548012A (zh) * | 2019-08-27 | 2019-12-10 | 嘉必优生物技术（武汉）股份有限公司 | 一种唾液酸片剂及其制备方法 |
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| US9511015B2 (en) | 2016-12-06 |
| IL224203B (en) | 2018-06-28 |
| US20130225513A1 (en) | 2013-08-29 |
| JP2013531041A (ja) | 2013-08-01 |
| US20170136051A1 (en) | 2017-05-18 |
| EP2593109A4 (en) | 2014-01-08 |
| US9554987B2 (en) | 2017-01-31 |
| WO2012009474A1 (en) | 2012-01-19 |
| BR112013000776A2 (pt) | 2016-05-24 |
| KR20140003380A (ko) | 2014-01-09 |
| CN103370069A (zh) | 2013-10-23 |
| JP5777712B2 (ja) | 2015-09-09 |
| US20130273160A1 (en) | 2013-10-17 |
| US20170157160A1 (en) | 2017-06-08 |
| EP2593109A1 (en) | 2013-05-22 |
| CA2805222A1 (en) | 2012-01-19 |
| AU2011279158A1 (en) | 2013-02-21 |
| AU2011279158B2 (en) | 2015-07-09 |
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