CN1085789A - Honeysuckle acne liquid - Google Patents
Honeysuckle acne liquid Download PDFInfo
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- CN1085789A CN1085789A CN 93107488 CN93107488A CN1085789A CN 1085789 A CN1085789 A CN 1085789A CN 93107488 CN93107488 CN 93107488 CN 93107488 A CN93107488 A CN 93107488A CN 1085789 A CN1085789 A CN 1085789A
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- parts
- herba
- liquid
- honeysuckle
- honeysuckle flower
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- 206010000496 acne Diseases 0.000 title claims abstract description 20
- 239000007788 liquid Substances 0.000 title claims abstract description 19
- 208000002874 Acne Vulgaris Diseases 0.000 title abstract description 11
- 241000205585 Aquilegia canadensis Species 0.000 title abstract 3
- 241000628997 Flos Species 0.000 claims abstract description 19
- 210000000582 semen Anatomy 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 3
- 241001570521 Lonicera periclymenum Species 0.000 claims description 9
- 241000206501 Actaea <angiosperm> Species 0.000 claims description 7
- 241000157835 Gardenia Species 0.000 claims description 7
- 241000245240 Lonicera Species 0.000 claims description 7
- 235000014435 Mentha Nutrition 0.000 claims description 3
- 241001072983 Mentha Species 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 15
- 208000017520 skin disease Diseases 0.000 abstract description 2
- 241000758794 Asarum Species 0.000 abstract 1
- 244000111489 Gardenia augusta Species 0.000 abstract 1
- 235000018958 Gardenia augusta Nutrition 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 239000000047 product Substances 0.000 description 13
- 238000001035 drying Methods 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 5
- 238000010171 animal model Methods 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 239000003440 toxic substance Substances 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000003748 differential diagnosis Methods 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000002085 irritant Substances 0.000 description 2
- 231100000021 irritant Toxicity 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 150000004492 retinoid derivatives Chemical class 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 235000011273 Benincasa Nutrition 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 241001349593 Praecitrullus Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000545442 Radix Species 0.000 description 1
- 208000032023 Signs and Symptoms Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000004856 capillary permeability Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 230000010354 integration Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 231100000668 minimum lethal dose Toxicity 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese patent medicine liquid which takes honeysuckle as a main component and is mainly used for treating acne skin diseases. The liquid medicine mainly comprises the following extracting solutions: 20-30 parts of honeysuckle, 2.5-7.5 parts of cape jasmine, 3.75-6.25 parts of dandelion, 2-3 parts of cortex dictamni, fructus cnidii, herba lycopi, radix angelicae, asarum, semen benincasae, rhizoma atractylodis and cimicifugae foetidae respectively. Mixing the above materials, distilling with steam, standing the distillate, and filtering to obtain flos Lonicerae acne liquid. The liquid medicine has high cure rate and no side effect.
Description
The present invention relates to a kind of Chinese medicinal liquid, particularly a kind of be main component with the Flos Lonicerae, cure mainly the dermopathic Chinese medicinal liquid of acne.
Acne claim acne again, it is one of common skin disease, treatment medically at present is often for oral administration or with preparation externals such as retinoid, antibiotics, benzoyl peroxide, sulfur lotions with vitamins, estrogen class, retinoid, endocrine preparation, antibiotics and zinc preparation, but effect is not good enough.Especially some Western medicine is because of there being side reaction safety inadequately.So up to the present also there is not a kind of specific drug that cures mainly acne.Continue to use traditional decoction oral or washout for the acne traditional Chinese medical science is many based on differential diagnosis of diseases determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs and differential diagnosis of diseases compound treatment, its prescription also varies with each individual, and does not form fixed dosage form, use extremely inconvenience, and effect is also not ideal.
The purpose of this invention is to provide a kind of good effect, safe in utilization easy be key component with the Flos Lonicerae, cure mainly the honeysuckle flower liquid for treating comedo of acne.
Scheme is to realize unhitching the object of the invention certainly: the honeysuckle flower liquid for treating comedo that is provided mainly is that the extracting solution by following material combines: 20~30 parts of Flos Loniceraes, 2.5~7.5 parts of Fructus Gardeniaes, 3.75~6.25 parts of Herba Taraxacis, each 2~3 parts of Cortex Dictamni, Fructus Cnidii, Herba Lycopi, the Radix Angelicae Dahuricae, Herba Asari, Semen Benincasae, Rhizoma Atractylodis and Rhizoma Cimicifugaes.
The inventor thinks from the angle of Chinese medicine: the cause of disease of acne mainly is that it is damp and hot to have the intestines and stomach concurrently based on wind and heat in the lung meridian, and the blood clots absorbing stagnates.Propose: the treatment to acne should be based on heat-clearing and toxic substances removing, dispelling wind and ventilating the lung, assistant with dampness, invigorate blood circulation, dispelling wind for relieving itching.Honeysuckle flower liquid for treating comedo provided by the present invention preparation with regard to being based on this theory.Flos Lonicerae wherein (also the someone is referred to as Flos Lonicerae) has heat-clearing and toxic substances removing, wind-heat dissipating effect for the monarch drug in the Chinese materia medica; Fructus Gardeniae, Herba Taraxaci are ministerial drug, and auxiliary Flos Lonicerae is to strengthen its heat-clearing toxin-expelling functions; Cortex Dictamni, Fructus Cnidii heat clearing and damp drying, Herba Asari, Radix Angelicae Dahuricae a surname lung meridian ailment said due to cold or exposure of loosing, Semen Benincasae, Rhizoma Atractylodis are drying damp and strengthening spleen, the pain that disappears of reducing phlegm, more than seven flavors be adjuvant drug altogether; Rhizoma Cimicifugae is a messenger drug, focuses on that to draw all medicines up, reaches in sick institute.
In above-mentioned ministerial drug, can also increase 2.5~7.5 parts of Herba Senecionis Scandentiss, 3.75~6.25 parts of Flos Chrysanthemi Indicis with heat-clearing and toxic substances removing, purging fire and cooling blood effect.In above-mentioned adjuvant drug, can also increase by 2~3 parts of Herba Menthaes, so that further heighten the effect of a treatment.
The best proportioning of above-mentioned each component is: 24~27 parts of Flos Loniceraes, 3~5 parts of Fructus Gardeniaes, 4~6 parts of Herba Taraxacis, 4~6 parts of Herba Senecionis Scandentiss, 4~5 parts of Flos Chrysanthemi Indicis, each 2~3 parts of Cortex Dictamni, Fructus Cnidii, Herba Lycopi, the Radix Angelicae Dahuricae, Herba Asari, Herba Menthae, Semen Benincasae, Rhizoma Atractylodis and Rhizoma Cimicifugaes.
Example 1
Take by weighing 26 parts of Flos Loniceraes; 4 parts of Fructus Gardeniaes cut sheet, drying; 5 parts of Herba Senecionis Scandentiss, cutting, drying; 4 parts of Flos Chrysanthemi Indicis; 2.5 parts of Cortex Dictamni, cut sheet, drying; 2.5 parts of Fructus Cnidiis; 2.5 parts of Herba Lycopi run through, cutting, drying; 2.5 parts of the Radixs Angelicae Dahuricae run through, cut sheet, drying; 2.5 parts of Herba Asaris, shower water moistens slightly, cutting is dried in the shade; 2.5 parts of Herba Menthaes, shower water moistens slightly, also cold drying in time of cutting; 2.5 parts of Semen Benincasaes pulverize; 2.5 parts of Rhizoma Atractylodis run through, cut sheet, drying; 2.5 parts of Rhizoma Cimicifugaes slightly steep, run through, cut sheet, drying.More than every part be 1 kilogram weight.
Above-mentioned each thing is mixed the back add 2 times of water gagings immersions 2 hours, carry out vapor distillation again, get distillate, then distillate is carried out the redistillation second time, in the end add 0.5% sodium benzoate antiseptic in the distillate of gained, leave standstill, filter, resulting colourless liquid is honeysuckle flower liquid for treating comedo.
It is the volatilizable character of extracting as much as possible in above-mentioned each thing that this product adopts the purpose of distil process, carry out single flash usually and get final product, but twice distillation can make product quality more stable.
Example 2
Take by weighing 20 parts of Flos Loniceraes, 7.5 parts of Fructus Gardeniaes, 4 parts of Herba Taraxacis, 3 parts of Herba Senecionis Scandentiss, each 2 parts of Cortex Dictamni, Fructus Cnidii, Herba Lycopi, the Radix Angelicae Dahuricae, Herba Asari, Semen Benincasae, Rhizoma Atractylodis and Rhizoma Cimicifugaes.Method for making is with example 1.
Example 3
Take by weighing 30 parts of Flos Loniceraes, 2.5 parts of Fructus Gardeniaes, 6.26 parts of Herba Taraxacis, 6 parts of Flos Chrysanthemi Indicis, each 3 parts of Cortex Dictamni, Fructus Cnidii, Herba Lycopi, the Radix Angelicae Dahuricae, Herba Asari, Herba Menthae, Semen Benincasae, Rhizoma Atractylodis and Rhizoma Cimicifugaes.Method for making is with example 1.
The usage of this product: behind the warm water cleaning affected part, with medicinal liquid partial smearing affected part, every day 3-5 time.Inactive cosmetics between the operating period, the greasy and pungent product of few edible oil.
The toxicological test of this product: all check by " specification requirement of new drug (Western medicine) toxicity ".
1, skin irritation test
Laboratory animal: rabbit.Method: local intact skin and damaged skin are smeared.
The result: the irritant reaction integration is zero, no local excitation reaction.
2, skin acute toxicity test
Laboratory animal: rabbit.Method: damaged skin is smeared with various dose.
Result: do not find the whole body poisoning symptom.
3, skin anaphylactic test
Laboratory animal: Cavia porcellus.
Result: do not find anaphylaxis.
4, acute toxicity test
Laboratory animal: white mice.Method: lumbar injection.
The result: minimum lethal dose is greater than 50g/kg, 6D
50Do not measure.
5, eye irritant test
Laboratory animal: rabbit.Method: in the eye conjunctival sac, inject this product.
The result: the average response value is zero, to the eye vacuum response.
The pharmacodynamics test of this product shows: this product can significantly suppress acute exudative inflammation and reduce capillary permeability; The paraplasm that androlin in the rat body is increased the sebaceous gland tissue morphology that causes has the obvious suppression effect, and can obviously reduce the quantity of sebaceous gland; The intravital serum Testosterone of rat level there is not obvious influence.
The clinical trial of this product:
Observe patient's totally 300 examples, all based on the out-patient.Be divided into treatment group and matched group, the treatment group is used this product, and matched group uses 10% sulfur lotion.
It is as shown in the table in two groups general curative effect contrast:
Total routine number | Recovery from illness | Produce effects | Effectively | Invalid | Effectively total | |
The treatment group | 240 | 88 (33.6) | 87 (36.3) | 47 (19.6) | 18 (7.5) | 222 (92.5) |
Matched group | 60 | 9 (15) | 17 (28.3) | 14 (23.3) | 20 (33.3) | 40 (66.7) |
Numeral in the table bracket is a percent.
In above-mentioned clinical trial, be that the total effective rate of wind and heat in the lung meridian (totally 155 examples) is 94.8% to traditional Chinese medical science typing, be that the total effective rate of papular type (totally 203 examples) is 97.5% to the doctor trained in Western medicine typing.
From as can be seen above: the total effective rate of this product is 92.5%, and the recovery from illness obvious effective rate is 72.9%, all is significantly higher than sulfur lotion commonly used at present, and does not have tangible untoward reaction.
This product is a colourless liquid, and topical application does not have greasy feeling, and good absorbing is not stayed any vestige, and safe in utilization easy, and particularly for patient and the course of disease short patient of great majority for papular type, the onset of this product is rapid, better efficacy.
Claims (4)
1, a kind of honeysuckle flower liquid for treating comedo, it is characterized in that main extracting solution by following material combines: 20~30 parts of Flos Loniceraes, 2.5~7.5 parts of Fructus Gardeniaes, 3.75~6.25 parts of Herba Taraxacis, each 2~3 parts of Cortex Dictamni, Fructus Cnidii, Herba Lycopi, the Radix Angelicae Dahuricae, Herba Asari, Semen Benincasae, Rhizoma Atractylodis and Rhizoma Cimicifugaes.
2, honeysuckle flower liquid for treating comedo as claimed in claim 1 is characterized in that also being added with 2.5~7.5 parts of Herba Senecionis Scandentiss, 3.75~6.25 parts of Flos Chrysanthemi Indicis.
3, honeysuckle flower liquid for treating comedo as claimed in claim 2 is characterized in that also being added with 2~3 parts of Herba Menthaes.
4, honeysuckle flower liquid for treating comedo as claimed in claim 3 is characterized in that 24~27 parts of Flos Loniceraes, 3~5.5 parts of Fructus Gardeniaes, 4~6 parts of Herba Taraxacis, 4~6 parts of Herba Senecionis Scandentiss, 4~5 parts of Flos Chrysanthemi Indicis, each 2~3 parts of Cortex Dictamni, Fructus Cnidii, Herba Lycopi, the Radix Angelicae Dahuricae, Herba Asari, Herba Menthae, Semen Benincasae, Rhizoma Atractylodis and Rhizoma Cimicifugaes.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 93107488 CN1085789A (en) | 1993-07-01 | 1993-07-01 | Honeysuckle acne liquid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 93107488 CN1085789A (en) | 1993-07-01 | 1993-07-01 | Honeysuckle acne liquid |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1085789A true CN1085789A (en) | 1994-04-27 |
Family
ID=4986710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 93107488 Pending CN1085789A (en) | 1993-07-01 | 1993-07-01 | Honeysuckle acne liquid |
Country Status (1)
Country | Link |
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CN (1) | CN1085789A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100360168C (en) * | 2005-12-14 | 2008-01-09 | 贾孝荣 | Chinese medicine composition for diminishing speckle and pox |
CN102357157A (en) * | 2011-11-14 | 2012-02-22 | 纪承寅 | Traditional Chinese medicine composition for treating skin acne with mite infection |
CN102771607A (en) * | 2012-08-16 | 2012-11-14 | 张士舜 | Herbal tea capable of eliminating excess fire and preparation method of herbal tea |
-
1993
- 1993-07-01 CN CN 93107488 patent/CN1085789A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100360168C (en) * | 2005-12-14 | 2008-01-09 | 贾孝荣 | Chinese medicine composition for diminishing speckle and pox |
CN102357157A (en) * | 2011-11-14 | 2012-02-22 | 纪承寅 | Traditional Chinese medicine composition for treating skin acne with mite infection |
CN102771607A (en) * | 2012-08-16 | 2012-11-14 | 张士舜 | Herbal tea capable of eliminating excess fire and preparation method of herbal tea |
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