CN108578537A - A kind of navel paster for treating insomnia - Google Patents
A kind of navel paster for treating insomnia Download PDFInfo
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- CN108578537A CN108578537A CN201810848719.9A CN201810848719A CN108578537A CN 108578537 A CN108578537 A CN 108578537A CN 201810848719 A CN201810848719 A CN 201810848719A CN 108578537 A CN108578537 A CN 108578537A
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- navel paster
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- borneol
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K35/10—Peat; Amber; Turf; Humus
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/69—Polygalaceae (Milkwort family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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Abstract
The present invention relates to a kind of navel paster for treating insomnia, the ointment of the navel paster is made of active ingredient and medically acceptable auxiliary material, which is characterized in that the active ingredient is made of the prepared slices of Chinese crude drugs of following weight percent：Corydalis tuber 14~18%, Flos Albiziae 9~12%, grass-leaved sweetflag 14~18%, Radix Polygalae 14~18%, Radix Angelicae Sinensis 10~14%, amber 3~5%, sanchi flower 5~7%, mother-of-pearl 5~7%, Schisandra chinensis 9~12%, borneol 3~5%.According to clinical verification, the navel paster significant effect for the treatment of insomnia of the present invention, total effective rate reach 91.18%, and without there is any clinical adverse.
Description
Invention field
The present invention relates to medicinal preparations, and in particular to the Chinese medicine system containing the treatment insomnia for not determining structure from plant
Agent.
Technical background
Insomnia, is often referred to that a kind of illness of ortho cannot be obtained.Its clinical manifestation have difficulty falling asleep, Yi Xing, wake up after
It is not easy to fall asleep, dreaminess or early awakening, severe patient or even lie awake all night, in the daytime with lassitude and weak, the dizzy diseases such as drowsy, apathetic
Shape seriously affects the study, work and life of people.Doctor trained in Western medicine mostly uses Benzodiazepines hypnotic drug or H1Receptor antagonist
(chlorphenamine maleate etc.) treatment insomnia, drug effect is very fast, but takes for a long time, is also easy to produce drug dependence.Chinese medicine claims to lose
It is " being insomnia " to sleep, and insomniac is mostly because of native endowment deficiency, and deficiency of liver-blood, liver body, which loses, supports, and blood does not give up soul, causes the state of mind uneasy,
Or long-time depressed emotion, it causes stagnation of liver qi, changes fire, insomnia and dreamful sleep occurs in the heart-yin of burning, and the key for the treatment of is soothing the liver clear
Heat, enrich blood Xie Yu, antitoxic heart-soothing and sedative.With the influence of many factors such as social living environment, the number of insomniac is on the increase.
The drug for the treatment of insomnia at present is mainly oral medicine, and treatment insomnia effect is limited.Chinese medicine insomnia is with a long history, has only
Special advantage.Therefore, seek a kind of effective drug of insomnia for the treatment of to have important practical significance.
Invention content
Technical problem to be solved by the invention is to provide a kind of navel paster for treating insomnia, the navel paster is significant in efficacy.
The scheme that the present invention solves above-mentioned technical problem is as follows：
A kind of navel paster for treating insomnia, the ointment of the navel paster is by active ingredient and medically acceptable auxiliary material group
At, which is characterized in that the active ingredient is made of the prepared slices of Chinese crude drugs of following weight percent：Corydalis tuber 14~18% closes
It is joyous to spend 9~12%, grass-leaved sweetflag 14~18%, Radix Polygalae 14~18%, Radix Angelicae Sinensis 10~14%, amber 3~5%, sanchi flower 5~7%,
Mother-of-pearl 5~7%, Schisandra chinensis 9~12%, borneol 3~5%.
In above-mentioned navel paster, the optimum weight percentage of the prepared slices of Chinese crude drugs is：Corydalis tuber 16%, Flos Albiziae 10%,
Grass-leaved sweetflag 16%, Radix Polygalae 16%, Radix Angelicae Sinensis 12%, amber 4%, sanchi flower 6%, mother-of-pearl 6%, Schisandra chinensis 10%, borneol 4%.
The ointment of navel paster of the present invention is prepared by following methods：The prepared slices of Chinese crude drugs are taken, are ground into thin
Vaseline and lanolin, mixing is added in powder.
Chinese medicine thinks that navel is congenital umbilical cord, the Qishe of the day after tomorrow, for the remittance sea through gas, the vital organs of the human body sheet, from navel
Administration can preferably play soothing liver-qi stagnation, soothing the liver of enriching blood, the effect of antitoxic heart-soothing and sedative.Navel paster of the present invention it is effective at
Divide by corydalis tuber, Flos Albiziae, grass-leaved sweetflag, Radix Polygalae, Radix Angelicae Sinensis, amber, sanchi flower, mother-of-pearl, Schisandra chinensis, borneol composition, Fang Zhong, stone
The effect of there is calamus intelligence development of allaying excitement, eliminating the phlegm to have one's ideas straightened out, dampness elimination appetizing, corydalis tuber have the effect of ataralgesia, the promoting flow of qi and blood circulation, altogether
For monarch drug in a prescription；Flos Albiziae has a resolving stagnation for tranquilization, qi-regulating appetizing, and the effect of active pain relieving, Radix Angelicae Sinensis has a replenishing and activating blood, menstruction regulating and pain relieving,
There is the effect of mental-tranquilization, expelling phlegm and arresting coughing, Schisandra chinensis to have kidney calming for the effect of relaxing bowel, Radix Polygalae, restrain astringent method, benefit
There is the effect of calming the liver, improving eyesight of calming the frightened, sanchi flower to have clearing heat and promoting fluid, soothing the liver decompression, town for the effect of gas promotes the production of body fluid, mother-of-pearl
The effect of quiet hypnosis, they can play liver soothing and depression relief, soothing the liver of enriching blood, the effect of antitoxic heart-soothing and sedative, and energy principal drug assistance plays tranquilizing soporific
Effect, be altogether ministerial drug；There is amber the effect of calmness, diuresis, promoting blood circulation, energy principal drug assistance and ministerial drug to play the role of tranquilizing the mind, be
Adjutant；Borneol plays the role of that other medicines is promoted to absorb, to make medicine.Soothing liver-qi stagnation is played altogether by full side, soothing the liver of enriching blood, antitoxic heart-soothing and sedative
Effect achievees the purpose that treatment insomnia.
In order to better understand the present invention, technique effect possessed by the present invention will be proved by clinical trial below.
One, clinical data
52 insomniacs (18~23 years old age) are randomly divided into two groups, treatment group is 34, and control group is 18.Two
Through statistical analysis, there was no significant difference (P ＞ 0.05) at age, gender, the course of disease etc. for group case, is comparable.
Two, diagnostic criteria
With reference to traditional Chinese and western medicine insomnia diagnostic criteria：1. the phase is slipped into sleep：Time for falling asleep is more than 30 minutes；2. sleep maintains：Night
Between awakening number be more than 2 times or morning early awakening；3. total sleeping time is less than 6 hours；5. residual effect in the daytime：Next day spirit is not
It shakes, daytime is drowsy, weak etc..
Three, exclusion criteria
The following either condition person of meeting：1. body organic disease, such as because of the somatopathies such as somatalgia and itch of having a stomachache
Caused by have a sleepless night；2. pregnancy or preparation pregnancy person and women breast-feeding their children；3. refusal signature informed consent form, violates testing program
Person.
Four, therapy
Treatment group：Navel paster described in Example 1 is slept first 3 hours and is attached on SHENQUE acupoint, and daily 1 patch continuously treats 7
It.
Control group：Oral Chlorate (alias chlorpheniramine), is slept preceding half an hour and is taken by daily 1, continuous to take
With 7 days.(referring to Guo Jia soil, Malaysian's essence, high sword English chlorpheniramines treat 65 observation of curative effect [J] of primary insomnia, Fujian medicine
Magazine, 1989,11 (5):51-52.)
Five, efficacy assessment standard
1, therapeutic evaluation：Clinical recovery：Sleeping time restores normal or nighttime sleep time at 6 hours or more, sleeps
It is deep, it is hale and hearty after waking up.It is effective:Sleep is clearly better, and time of sleep increases by 3 hours or more, and the depth of sleep increases.Have
Effect:Symptom mitigates, and the time of sleep increased earlier above less than 3 hours.In vain:After treatment insomnia without substantially change or instead plus
Severe one.
2, symptom integral evaluation criterion：It is scored using Athens insomnia scale (AIS)：It is divided into time for falling asleep (to arrive after turning off the light
Time asleep), night revival, than desired time early awakening, total sleep time, total sleep quality (how long no matter sleep), daytime
Mood, daytime, body function was (physical or spiritual：Such as memory, cognitive power and attention), Eight problems scoring that daytime is drowsy,
It is divided into four options according to severity, option presses 0 point by severity of symptom, and 1 point, 2 points, 3 points are scored.
Six, treatment results
Total data is for statistical analysis using 17.0 statistics softwares of SPSS.Enumeration data is indicated with x ± s, is compared
It is examined using t, ranked data are indicated with number of cases, are compared using rank sum test.P<0.05 indicates that difference has statistical significance.
Clinical therapeutic efficacy, which compares, sees Tables 1 and 2.
1 two groups of therapeutic effects of table compare
Note：※ indicates treatment group P ＜ 0.05 compared with the control group.
2 two groups of AIS integral contrasts of table
Note：# indicates to compare P ＜ 0.05 before and after treatment with group.
Can be seen that treatment group from the data in table, total effective rate is higher than control group compared with the control group, and difference has system
Meter learns meaning (P ＜ 0.05).Before treatment, two groups of AIS integral differences do not have statistical significance；It is pretherapy and post-treatment with group after treatment
Compare, integral significant difference (P ＜ 0.05)；After treatment, treatment group does not have statistical significance (P ＞ with control group integral difference
0.05).The significant effect of navel paster treatment insomnia of the present invention, total effective rate are up to 91.18%, and without there is any clinic not
Good reaction.
Specific implementation mode
Corydalis tuber in following embodiments, Flos Albiziae, grass-leaved sweetflag, Radix Polygalae, Radix Angelicae Sinensis, amber, sanchi flower, mother-of-pearl, the five tastes
Son, borneol are medicine materical crude slice.Navel paster described in following embodiments, often the dosage of adhesive plaster is 0.6 gram by crude drug gauge.
Embodiment 1
1, prescription：Corydalis tuber 48g, Flos Albiziae 30g, grass-leaved sweetflag 48g, Radix Polygalae 48g, Radix Angelicae Sinensis 36g, amber 12g, sanchi flower
18g, mother-of-pearl 18g, Schisandra chinensis 30g, borneol 12g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 270g, lanolin 30g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Embodiment 2
1, prescription：Corydalis tuber 45g, Flos Albiziae 28g, grass-leaved sweetflag 49g, Radix Polygalae 52g, Radix Angelicae Sinensis 41g, amber 12g, sanchi flower
19g, mother-of-pearl 16g, Schisandra chinensis 28g, borneol 10g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 210g, lanolin 90g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Embodiment 3
1, prescription：Corydalis tuber 51g, Flos Albiziae 29g, grass-leaved sweetflag 47g, Radix Polygalae 45g, Radix Angelicae Sinensis 32g, amber 10g, sanchi flower
19g, mother-of-pearl 19g, Schisandra chinensis 35g, borneol 13g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 240g, lanolin 60g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Embodiment 4
1, prescription：Corydalis tuber 53g, Flos Albiziae 31g, grass-leaved sweetflag 46g, Radix Polygalae 44g, Radix Angelicae Sinensis 31g, amber 12g, sanchi flower
16g, mother-of-pearl 19g, Schisandra chinensis 34g, borneol 14g.
2, preparation method：Above-mentioned prescription medicine medicine materical crude slice is ground into 80 mesh fine powders；Take vaseline 250g, lanolin 50g and medicine
Powder mixing, obtains ointment；Ointment is placed on desensitization adhesive plaster, adherent layer is to get the navel paster in covering.
Claims (3)
1. the ointment of a kind of navel paster for treating insomnia, the navel paster is made of active ingredient and medically acceptable auxiliary material,
It is characterized in that, the active ingredient is made of the prepared slices of Chinese crude drugs of following weight percent：Corydalis tuber 14~18%, Flos Albiziae
9~12%, grass-leaved sweetflag 14~18%, Radix Polygalae 14~18%, Radix Angelicae Sinensis 10~14%, amber 3~5%, sanchi flower 5~7%, pearl
Mother 5~7%, Schisandra chinensis 9~12%, borneol 3~5%.
2. a kind of navel paster for treating insomnia according to claim 1, which is characterized in that the weight of the prepared slices of Chinese crude drugs
Percentage is：Corydalis tuber 16%, Flos Albiziae 10%, grass-leaved sweetflag 16%, Radix Polygalae 16%, Radix Angelicae Sinensis 12%, amber 4%, sanchi flower
6%, mother-of-pearl 6%, Schisandra chinensis 10%, borneol 4%.
3. a kind of navel paster for treating insomnia according to claim 1 or 2, which is characterized in that the ointment of the navel paster by
Following methods are made：The prepared slices of Chinese crude drugs are taken, fine powder is ground into, vaseline and lanolin, mixing is added.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810848719.9A CN108578537A (en) | 2018-07-28 | 2018-07-28 | A kind of navel paster for treating insomnia |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810848719.9A CN108578537A (en) | 2018-07-28 | 2018-07-28 | A kind of navel paster for treating insomnia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109847024A (en) * | 2019-04-01 | 2019-06-07 | 重庆三峡医药高等专科学校 | A kind of Chinese medicine composition that treating insomnia and its navel paster of preparation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201349839Y (en) * | 2009-02-04 | 2009-11-25 | 贾良栋 | Medicine pillow |
| CN107536991A (en) * | 2016-06-28 | 2018-01-05 | 西安交通大学第附属医院 | A kind of compound medicine for treating insomnia and preparation method thereof |
-
2018
- 2018-07-28 CN CN201810848719.9A patent/CN108578537A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201349839Y (en) * | 2009-02-04 | 2009-11-25 | 贾良栋 | Medicine pillow |
| CN107536991A (en) * | 2016-06-28 | 2018-01-05 | 西安交通大学第附属医院 | A kind of compound medicine for treating insomnia and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109847024A (en) * | 2019-04-01 | 2019-06-07 | 重庆三峡医药高等专科学校 | A kind of Chinese medicine composition that treating insomnia and its navel paster of preparation |
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