CN108576781A - A kind of multi-vitamins and preparation method thereof - Google Patents
A kind of multi-vitamins and preparation method thereof Download PDFInfo
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- CN108576781A CN108576781A CN201810446782.XA CN201810446782A CN108576781A CN 108576781 A CN108576781 A CN 108576781A CN 201810446782 A CN201810446782 A CN 201810446782A CN 108576781 A CN108576781 A CN 108576781A
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- vitamin
- parts
- vitamins
- antioxidant
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- 239000011782 vitamin Substances 0.000 title claims abstract description 96
- 229940088594 vitamin Drugs 0.000 title claims abstract description 83
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 229930003231 vitamin Natural products 0.000 claims abstract description 58
- 235000013343 vitamin Nutrition 0.000 claims abstract description 58
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 57
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 24
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 23
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 23
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 23
- 239000004094 surface-active agent Substances 0.000 claims abstract description 20
- 239000004064 cosurfactant Substances 0.000 claims abstract description 19
- MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 claims abstract description 16
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 16
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims abstract description 15
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims abstract description 13
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 13
- 239000008158 vegetable oil Substances 0.000 claims abstract description 13
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 12
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract description 12
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 12
- 229930182817 methionine Natural products 0.000 claims abstract description 12
- 229940101267 panthenol Drugs 0.000 claims abstract description 12
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 12
- 239000011619 pantothenol Substances 0.000 claims abstract description 12
- 239000011718 vitamin C Substances 0.000 claims abstract description 12
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 12
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 9
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 9
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 9
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 9
- 239000011719 vitamin A Substances 0.000 claims abstract description 9
- 229940045997 vitamin a Drugs 0.000 claims abstract description 9
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims abstract description 8
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 8
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 8
- 229930003779 Vitamin B12 Natural products 0.000 claims abstract description 8
- 229930003471 Vitamin B2 Natural products 0.000 claims abstract description 8
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract description 8
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims abstract description 8
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960002477 riboflavin Drugs 0.000 claims abstract description 8
- 235000019163 vitamin B12 Nutrition 0.000 claims abstract description 8
- 239000011715 vitamin B12 Substances 0.000 claims abstract description 8
- 235000019164 vitamin B2 Nutrition 0.000 claims abstract description 8
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 8
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 8
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 8
- 235000012711 vitamin K3 Nutrition 0.000 claims abstract description 8
- 239000011652 vitamin K3 Substances 0.000 claims abstract description 8
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 8
- 229930003451 Vitamin B1 Natural products 0.000 claims abstract description 5
- 229960003495 thiamine Drugs 0.000 claims abstract description 5
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 5
- 235000010374 vitamin B1 Nutrition 0.000 claims abstract description 5
- 239000011691 vitamin B1 Substances 0.000 claims abstract description 5
- 239000004615 ingredient Substances 0.000 claims abstract description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- 239000012071 phase Substances 0.000 claims description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 239000003921 oil Substances 0.000 claims description 10
- 235000019198 oils Nutrition 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 claims description 8
- 239000004250 tert-Butylhydroquinone Substances 0.000 claims description 8
- 235000019281 tert-butylhydroquinone Nutrition 0.000 claims description 8
- 239000008346 aqueous phase Substances 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 6
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 6
- AZJQQNWSSLCLJN-UHFFFAOYSA-N 2-ethoxyquinoline Chemical compound C1=CC=CC2=NC(OCC)=CC=C21 AZJQQNWSSLCLJN-UHFFFAOYSA-N 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims description 4
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims description 4
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims description 4
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims description 4
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
- 229920000053 polysorbate 80 Polymers 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 235000006109 methionine Nutrition 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- XKZQKPRCPNGNFR-UHFFFAOYSA-N 2-(3-hydroxyphenyl)phenol Chemical compound OC1=CC=CC(C=2C(=CC=CC=2)O)=C1 XKZQKPRCPNGNFR-UHFFFAOYSA-N 0.000 claims 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- LLJZKKVYXXDWTB-UHFFFAOYSA-N acetic acid;sodium Chemical compound [Na].[Na].CC(O)=O LLJZKKVYXXDWTB-UHFFFAOYSA-N 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 238000009738 saturating Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract description 4
- 239000007788 liquid Substances 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 4
- 239000004530 micro-emulsion Substances 0.000 abstract description 4
- 206010034960 Photophobia Diseases 0.000 abstract description 2
- 229930003427 Vitamin E Natural products 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract description 2
- 238000000593 microemulsion method Methods 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- 230000009467 reduction Effects 0.000 abstract description 2
- 230000008542 thermal sensitivity Effects 0.000 abstract description 2
- 235000019165 vitamin E Nutrition 0.000 abstract description 2
- 239000011709 vitamin E Substances 0.000 abstract description 2
- 229940046009 vitamin E Drugs 0.000 abstract description 2
- 239000006101 laboratory sample Substances 0.000 description 12
- 241000287828 Gallus gallus Species 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 11
- 235000013330 chicken meat Nutrition 0.000 description 10
- 239000000047 product Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 239000002904 solvent Substances 0.000 description 6
- 230000003321 amplification Effects 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000003199 nucleic acid amplification method Methods 0.000 description 4
- 238000010587 phase diagram Methods 0.000 description 4
- 150000002989 phenols Chemical class 0.000 description 4
- 239000013068 control sample Substances 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000007908 nanoemulsion Substances 0.000 description 3
- 244000144977 poultry Species 0.000 description 3
- 235000013594 poultry meat Nutrition 0.000 description 3
- 241000186000 Bifidobacterium Species 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- -1 VitAVitE Substances 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- LHGVFZTZFXWLCP-UHFFFAOYSA-N guaiacol Chemical compound COC1=CC=CC=C1O LHGVFZTZFXWLCP-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 231100000567 intoxicating Toxicity 0.000 description 1
- 230000002673 intoxicating effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000002114 nanocomposite Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 235000020195 rice milk Nutrition 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
- A23L29/04—Fatty acids or derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of multi-vitamins and preparation method thereof, multi-vitamins include formula as below ingredient：Vegetable oil,Vitamin A,Vitamin E,Vitamine D3,Vitamin B1,Vitamin B2,Vitamin B6,Vitamin C,Vitamin K3,Vitamin B12,Antioxidant,Disodium ethylene diamine tetraacetate,Surfactant,Cosurfactant,Methionine,Panthenol,Xylo-oligosaccharide,The present invention forms the microemulsion particles with thermodynamic stable system using microemulsion method and advanced interfacial process,Utilize surface tension different between each biostearin,And moment carries out biomembrane profound level embedding on a molecular scale,Make different pH values,Different thermal sensitivities,The vitamin and other nutriments of different light sensitivities and different redox conditions are co-located in the liquid of same discontinuous phase,Stablize each other and does not interfere with each other,It efficiently solves the problems, such as to make the reduction of vitamin potency since environmental factor is unstable,Stability is high.
Description
Technical field
The present invention relates to vitamin preparation technical fields, in particular to a kind of multi-vitamins and preparation method thereof.
Background technology
Vitamin is necessary to a kind of body maintains eubolism and physiological function, and the seldom low molecule of requirement has
Machine compound.Vitamin is neither Energy supply material nor the constituent of the various histoorgans of animal body, they are mainly with coenzyme
The form of (or prothetic group) participates in a variety of chemical reactions being metabolized in vivo, is metabolized with Auto-regulator for controlling, is teleorganic
Active material, therefore it is also the essential component in animal and fowl fodder.Vitamin can be divided into liposoluble vitamin according to dissolubility
And water soluble vitamin.
The vitamin industry in China is started in the eighties in last century, and by development in more than 20 years, China had become at present
The production and consumption big country of feeding vitamin, tens yuan of annual value of production, but for a long time, vitamin feed additive dosage form list
One, it is essentially all to be added in feed in the form of premix.As people recognize best vitamin (OVN) theory
Know：Effective replenishing vitamins during livestock and poultry cultivation improve livestock and poultry anti-adversity ability, reduce cultivated animals onset risk, promote
Cultivated animals play best production performance, will increasingly be recognized by people.With feed processing technology in recent years into
Step, nano-composite vitamin are increasingly becoming the common recognition of people.Therefore, in livestock and poultry cultivation and field of feed processing, to high quality
Vitamine supplement there is the huge market demands, still, the vitamin generally existing stability difference of existing market is asked
Topic, causes the vitamin resting period shorter, increases feeding cost.
Invention content
Application No. is 201110005491.5, a kind of entitled fat-soluble vitamin nano microemulsion oral liquid discloses
A kind of liposoluble vitamin, inventor have carried out stability experiment to liposoluble vitamin, it is found that the liposoluble vitamin exists
The problem of stability difference.Inventor is improved on this basis to original vitamin formula and preferred recipe ingredient, most
Obtain eventually it is a kind of have by surfactant, cosurfactant, antioxidant, liposoluble vitamin, water soluble vitamin,
The multi-vitamins and preparation method thereof of the transparent and isotropic thermodynamic stable system of amino acid and purified water composition.
To achieve the above object, the present invention provides the following technical solutions：
A kind of multi-vitamins, including formula as below ingredient：Vegetable oil, VitAVitE, vitamine D3, dimension life
Plain B1, vitamin B2, vitamin B6, vitamin C, Vitamin K3, vitamin B12, antioxidant, disodium ethylene diamine tetraacetate,
Surfactant, cosurfactant, methionine, panthenol, xylo-oligosaccharide；
The formula components are according to mass fraction：The unit of 2~5 parts of vegetable oil, vitamin A 900~13,000,000, vitamin
E15~20 part, 200~600 unit of vitamine D3,1~5 part of vitamin B1,2~5 parts of vitamin B2, vitamin B6 1~3
Part, 2~15 parts of vitamin C, 1~3 part of Vitamin K3,0.007~0.012 part of vitamin B12, antioxidant 0.06~
0.18 part, 3~5 parts of disodium ethylene diamine tetraacetate, 50~60 parts of surfactant, 25~30 parts of cosurfactant, methionine 4
~7 parts, 10~16 parts of panthenol, 40~60 parts of xylo-oligosaccharide.
Further, due in the structure of vitamin A tool there are one the cyclohexene of conjugated polyene alcohol side chain, there are many it is vertical
Body isomers, therefore, there are multiple unsaturated bonds, and then cause its property extremely unstable, easily by air oxygen or oxidation
Agent aoxidizes, and also easily by ultraviolet photodestruciton, especially in the presence of heating and metal ion, is more easy to oxidation deterioration.To improve vitamin A
Stability, in addition to needing nitrogen charging, inventor is additionally added suitable antioxidant.The antioxidant is ethoxyquinoline, fourth
One or more of base hydroxyanisole, 2,6 di tert butyl 4 methyl phenol, tert-butyl hydroquinone combine.
Further, the antioxidant is the composition of 2,6- di-tert-butyl-4-methy phenols and tert-butyl hydroquinone,
And 0.05~0.15 part of 2,6 di tert butyl 4 methyl phenol, 0.01~0.03 part of tert-butyl hydroquinone.
Further, the surfactant be Tween-80 or Crodaret, it is described to help surface-active
Agent is absolute ethyl alcohol or propylene glycol.
Further, preferably, a kind of multi-vitamins, including following mass fraction formula components：
The unit of 2~5 parts of vegetable oil, vitamin A 900~13,000,000,5~20 parts of vitamin e1, vitamine D3 200~600
Unit, 1~5 part of vitamin B1,2~5 parts of vitamin B2,1~3 part of vitamin B6,2~15 parts of vitamin C, Vitamin K3
1~3 part, 0.007~0.012 part of vitamin B12,0.05~0.15 part of 2,6 di tert butyl 4 methyl phenol, tertiary butyl pair
0.01~0.03 part of benzenediol, 3~5 parts of disodium ethylene diamine tetraacetate, 50~60 parts of Crodaret, propylene glycol 25
~30 parts, 4~7 parts of methionine, 10~16 parts of panthenol, 40~60 parts of xylo-oligosaccharide.
In addition, the present invention also provides a kind of preparation method of multi-vitamins, include the following steps：
S1：Prepare oil-phase solution；
S2：Prepare aqueous phase solution；
S3：Under nitrogen protection, aqueous phase solution is added dropwise in oil-phase solution, is stirred when being added dropwise, until being formed equal
Matter clear solution adjusts PH to 4.0~6.0 to get finished product.
Further, the preparation method of the oil-phase solution is：
It weighs vegetable oil and is heated to 40-50 DEG C, under nitrogen protection, be firstly added antioxidant and stir to molten
Solution is uniform, then sequentially adds VitAVitE and vitamine D3 and is stirred respectively to being uniformly dissolved, is finally sequentially added
Surfactant, cosurfactant are simultaneously stirred respectively to being uniformly dissolved, you can.
Further, the preparation method of the aqueous phase solution is：
650~700 parts of purified water is taken, under stiring, sequentially adds vitamin B1, vitamin B2, vitamin B6, dimension life
Plain K3, vitamin B12, vitamin C, methionine, panthenol, xylo-oligosaccharide, stirring to dissolving, you can.
The beneficial effects of the invention are as follows：
Multi-vitamins are prepared using microemulsion method, meanwhile, advanced interfacial process is used, small fat-soluble dimension is made
Raw element " oil droplet " is surrounded by single interface that surfactant, cosurfactant and antioxidant are formed, and forms micro emulsion
Grain, grain size is between 15.3~31.8nm.In addition, using surface tension different between each biostearin, and in molecular level
Upper moment carries out biomembrane profound level embedding, makes different pH values, different thermal sensitivities, different light sensitivities and different redox journeys
The vitamin of degree and other nutriments are co-located in the liquid of same discontinuous phase, are stablized each other and are not interfere with each other, effectively
It solves the problems, such as to make the reduction of vitamin potency since environmental factor is unstable, stability is high.
Description of the drawings
Fig. 1 (a) is particle shape figure of laboratory sample under the conditions of amplification factor is 50,000 times in contrast experiment one；
Fig. 1 (b) is particle shape figure of laboratory sample under the conditions of amplification factor is 10,000 times in contrast experiment one.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment one：
A kind of multi-vitamins, including following mass fraction formula components：2~5 parts of vegetable oil, vitamin A 900~1300
Ten thousand units, 5~20 parts of vitamin e1,200~600 unit of vitamine D3,1~5 part of vitamin B1,2~5 parts of vitamin B2,
1~3 part of vitamin B6,2~15 parts of vitamin C, 1~3 part of Vitamin K3,0.007~0.012 part of vitamin B12, antioxygen
0.06~0.18 part of agent, 3~5 parts of disodium ethylene diamine tetraacetate, 50~60 parts of surfactant, cosurfactant 25~30
Part, 4~7 parts of methionine, 10~16 parts of panthenol, 40~60 parts of xylo-oligosaccharide, wherein the antioxidant be ethoxyquinoline,
One or more of butylated hydroxy anisole, 2,6- di-tert-butyl-4-methy phenols, tert-butyl hydroquinone combine, described
Surfactant is Tween-80 or Crodaret, and the cosurfactant is absolute ethyl alcohol or the third two
Alcohol.
In addition, the present invention also provides a kind of preparation method of multi-vitamins, include the following steps：
S1, oil-phase solution is prepared：It weighs vegetable oil and is heated to 40-50 DEG C, under nitrogen protection, be firstly added anti-
Oxidant is simultaneously stirred to being uniformly dissolved, and then sequentially adds VitAVitE and vitamine D3 and respectively stirring extremely dissolving
Uniformly, surfactant, cosurfactant are finally sequentially added and is stirred respectively to being uniformly dissolved, you can；
S2, aqueous phase solution is prepared：650~700 parts of purified water is taken, under stiring, sequentially adds vitamin B1, vitamin
B2, vitamin B6, Vitamin K3, vitamin B12, vitamin C, methionine, panthenol, xylo-oligosaccharide, stirring to dissolving, you can；
S3, under nitrogen protection, aqueous phase solution is added dropwise in oil-phase solution, stir when being added dropwise, until being formed
Matter clear solution adjusts PH to 4.0~6.0 to get finished product.
Embodiment two：
The present embodiment part identical with embodiment one repeats no more, unlike：
Inventor selects best antioxidant to be used to prepare multi-vitamins, has carried out following experiment：
Experimental program one：Using ethoxyquinoline as antioxidant, dosage is 0.06~0.18 part；
Experimental program two：Using butylated hydroxy anisole as antioxidant, dosage is 0.01g~0.05g；
Experimental program three：Using 2,6- di-tert-butyl-4-methy phenols as antioxidant, dosage be 0.05g~
0.15g；
Experimental program four：Using tert-butyl hydroquinone as antioxidant, dosage is 0.01g~0.05g；
Experimental program five：Using 0.05~0.15g+ of 2,6 di tert butyl 4 methyl phenol tert-butyl hydroquinone 0.01
The combination of~0.03g is as antioxidant；
Experimental program six：Using 0.01~0.03g+2,6- of butylated hydroxy anisole di-tert-butyl-4-methy phenols 0.05
The combination of 0.1~0.3g of~0.15g+ ethoxyquinolines is as antioxidant.
In addition, experimental program one to six is all made of the preparation method described in embodiment one, inventor's tracing detection finished product is multiple
The stability for closing vitamin is found：Finished product stability prepared by experimental program five is best.
Meanwhile inventor's matching using pseudo-ternary phase diagram screening surfactant, cosurfactant and oil phase solvent
Than specially：By surfactant and cosurfactant according to 2：1 mixing, obtains mixed liquor, by mixed liquor and oil phase solvent
It is respectively 9 according to mass ratio：1；8：2；7：3；6：4；5：5；4：6；3：7；2：8；1：9 gradeds, oil phase solvent is flower herein
Oil generation, such as by Tween-80 and absolute ethyl alcohol according to 2：Mixed liquor is obtained after 1 mixing, mixed liquor is with peanut oil according to quality
Than being 9：1；8：2；7：3；6：4；5：5；4：6；3：7；2：8；1：9 gradeds.It is first stirred evenly after mixing, then side, which is added dropwise, steams
Distilled water side is stirred, and observation system becomes muddy from clarifying, then the phenomenon that become clarification from muddiness, each component when recording critical point
Mass fraction, using surfactant and cosurfactant as the 1 of ternary phase diagrams vertex (S), oil phase solvent and water difference
For another 2 vertex (O, W) of ternary phase diagrams, curve is drawn in pseudo-ternary phase diagram, determines nano-emulsion area, is received according in each phasor
Size, Emulsion particle size and the stability in rice milk area, filter out the proportioning of surfactant, cosurfactant and oil phase solvent,
As optimum formula.As a result it shows：Crodaret is surfactant, propylene glycol is cosurfactant, and
The mixed liquor of surfactant and cosurfactant is 8 with oil phase：When 2, the nano-emulsion of making, appearance transparent, viscosity is small, property
Matter is stablized.
In conclusion preferably, the multi-vitamins include following mass fraction formula components：
The unit of 2~5 parts of vegetable oil, vitamin A 900~13,000,000,5~20 parts of vitamin e1, vitamine D3 200~600
Unit, 1~5 part of vitamin B1,2~5 parts of vitamin B2,1~3 part of vitamin B6,2~15 parts of vitamin C, Vitamin K3
1~3 part, 0.007~0.012 part of vitamin B12,0.05~0.15 part of 2,6 di tert butyl 4 methyl phenol, tertiary butyl pair
0.01~0.03 part of benzenediol, 3~5 parts of disodium ethylene diamine tetraacetate, 50~60 parts of Crodaret, propylene glycol 25
~30 parts, 4~7 parts of methionine, 10~16 parts of panthenol, 40~60 parts of xylo-oligosaccharide.Herein, oil phase solvent includes vegetable oil, dimension
Raw element A, vitamin E and vitamine D3.
Contrast experiment one：
Multi-vitamins are prepared simultaneously according to the disclosed formula of embodiment two, using the method prepared disclosed in embodiment
It is labeled as laboratory sample, is taken application No. is 201110005491.5, a kind of entitled fat-soluble vitamin nano microemulsion oral
The finished product of liquid is simultaneously labeled as control sample, and carrying out particle shape, particle diameter distribution and finished appearance to laboratory sample detects, specifically such as
Under：
1, particle diameter distribution detects：Using BT-90 nanometer laser Analyzer testing results, grain size average grain on the basis of volume
Diameter is 21.5nm, and particle diameter distribution accounts for 100% in 15.3~31.8nm.
2, particle shape detects：It takes and receives dimension in right amount, after diluting 1 times with distilled water, drop on the copper mesh for being covered with and supporting film, it is quiet
It is blotted with filter paper after setting 10min, then 20mg/mL Salkowski's solutions is added dropwise in negative staining 3min on copper mesh, volatilized naturally, in Electronic Speculum
The form of lower observation nano-emulsion drop is as shown in Figure 1, wherein Fig. 1 (a) amplification factors are 50,000 times, and the amplification factor of Fig. 1 (b) is
10000 times, as seen from Figure 1, particle shape is spherical in shape, even droplet distribution, and soilless sticking phenomenon shows favorable dispersibility.
Contrast experiment two：
Inventor tests the stability of laboratory sample in contrast test one, control sample, specific as follows：
1, laboratory sample is placed under 40 DEG C of environment and carries out stablizing experiment, experimental result is shown in Table 1.
Table 1：
2, laboratory sample, control sample are placed under 60 DEG C of environment and carry out stablizing experiment, experimental result is shown in Table 2.
Table 2：
It can be seen that by table 1, table 2：Property extremely unstable compared to conventional vitamin content is (substantially after producing half a year with regard under
Drop to 50% or less), after 40 DEG C of long-time stability are tested and high temperature is tested, the stability of product carries laboratory sample significantly
It is high.
Contrast experiment three：
Bifidus factor is added in the formula of laboratory sample ----xylo-oligosaccharide enhances the immunizing health function of vitamin.
It is verified through large quantities of clinical effectiveness, xylo-oligosaccharide is added in multi-vitamins, can not only increase the stability of product, but also
Clinically have received extraordinary using effect.Xylo-oligosaccharide acidproof heat-proof itself, stability is very good, is in polymerization carbohydrate
It is proliferated one of strongest kind of Bifidobacterium function, it can promote Bifidobacterium to be proliferated, and generate a variety of organic acids, reduce enteron aisle
PH value not only inhibits the growth of a large amount of harmful bacterias, makes probiotics mass propagation, improves microorganism species balance, and can hinder
The combination of disconnected pathogen and host cell receptor, stimulates the immune system of animal body, improves immunity, enhances the disease-resistant of animal
Ability, the addition of xylo-oligosaccharide create better environment to multi-vitamins, enhance the immune and health care of vitamin
Function, make they and high dissolving, high-selenium corn, high nutrition vitamin obtained on nanotechnology this platform it is perfectly warm.
In this regard, inventor carries out safety to laboratory sample, clinical evaluation is tested.
Test objective：The safety that assessment laboratory sample (Na Wei) uses on broiler chicken
Experimental animal：1 age in days AA+ white meat-type chickens
Test site：Animal house henhouse
Testing program grouping such as table 3.
Table 3：
Evaluation index：Each group starts that above-mentioned usage amount is used continuously respectively in 1 age in days, and it is small to drink 9 daily for every group of 7 chickens
When, it continuously drinks seven days.During the experiment, whether the state of mind of observation test group chicken group has an impact, testing index and side
Method：Observe the chicken group state of mind, feather color state, leg color state, death condition, weight, test result such as 4 institute of table
Show.
Table 4：
As can be seen from Table 4：Laboratory sample does not have any influence to the safety of chicken, and the state of mind of chicken group is good,
Fur is smooth, and legs and feet are not dried, and excrement molding is without phenomenon of having loose bowels.Meanwhile normal amount, 5 times of amount group chicken weight are apparently higher than sky
White control group chicken weight.It is observed after dissection, chicken uses experiment sample without intoxicating phenomenon, and compared to blank control group
The chicken of product is superior to blank control group to the absorption of yolk stalk.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (8)
1. a kind of multi-vitamins, it is characterised in that：Including formula as below ingredient：Vegetable oil, VitAVitE, dimension life
Plain D3, vitamin B1, vitamin B2, vitamin B6, vitamin C, Vitamin K3, vitamin B12, antioxidant, ethylenediamine tetraacetic
Acetic acid disodium, surfactant, cosurfactant, methionine, panthenol, xylo-oligosaccharide；
The formula components are according to mass fraction：The unit of 2~5 parts of vegetable oil, vitamin A 900~13,000,000, vitamin e1 5
~20 parts, 200~600 unit of vitamine D3,1~5 part of vitamin B1,2~5 parts of vitamin B2,1~3 part of vitamin B6,
2~15 parts of vitamin C, 1~3 part of Vitamin K3,0.007~0.012 part of vitamin B12,0.01~0.3 part of antioxidant,
3~5 parts of disodium ethylene diamine tetraacetate, 50~60 parts of surfactant, 25~30 parts of cosurfactant, 4~7 parts of methionine,
10~16 parts of panthenol, 40~60 parts of xylo-oligosaccharide.
2. a kind of multi-vitamins according to claim 1, it is characterised in that：The antioxidant be ethoxyquinoline,
One or more of butylated hydroxy anisole, 2,6 di tert butyl 4 methyl phenol, tert-butyl hydroquinone combine.
3. a kind of multi-vitamins according to claim 2, it is characterised in that：The antioxidant is bis- tertiary fourths of 2,6-
The composition of base -4- methylphenols and tert-butyl hydroquinone, and 0.05~0.15 part of 2,6- di-tert-butyl-4-methy phenol,
0.01~0.03 part of tert-butyl hydroquinone.
4. a kind of multi-vitamins according to claim 3, it is characterised in that：The surfactant is polysorbate-
80 or Crodaret, the cosurfactant is absolute ethyl alcohol or propylene glycol.
5. a kind of multi-vitamins according to claim 4, it is characterised in that：Including following mass fraction formula components：
The unit of 2~5 parts of vegetable oil, vitamin A 900~13,000,000,5~20 parts of vitamin e1, vitamine D3 200~600 are single
Position, 1~5 part of vitamin B1,2~5 parts of vitamin B2,1~3 part of vitamin B6,2~15 parts of vitamin C, Vitamin K3 1
~3 parts, 0.007~0.012 part of vitamin B12,0.05~0.15 part of 2,6 di tert butyl 4 methyl phenol, tertiary butyl is to benzene
0.01~0.03 part of diphenol, 3~5 parts of disodium ethylene diamine tetraacetate, 50~60 parts of Crodaret, propylene glycol 25~
30 parts, 4~7 parts of methionine, 10~16 parts of panthenol, 40~60 parts of xylo-oligosaccharide.
6. a kind of preparation method preparing multi-vitamins as described in claim 1, it is characterised in that：Include the following steps：
S1：Prepare oil-phase solution；
S2：Prepare aqueous phase solution；
S3：Under nitrogen protection, aqueous phase solution is added dropwise in oil-phase solution, is stirred when being added dropwise, until it is saturating to form homogeneous
Bright solution adjusts PH to 4.0~6.0 to get finished product.
7. a kind of preparation method of multi-vitamins according to claim 6, it is characterised in that：In the step S1, oil
The preparation method of phase solution is：
It weighs vegetable oil and is heated to 40-50 DEG C, under nitrogen protection, be firstly added antioxidant and stir equal to dissolving
It is even, it then sequentially adds VitAVitE and vitamine D3 and is stirred respectively to being uniformly dissolved, finally sequentially add surface
Activating agent, cosurfactant are simultaneously stirred respectively to being uniformly dissolved, you can.
8. a kind of preparation method of multi-vitamins according to claim 6, it is characterised in that：In the step S2, water
The preparation method of phase solution is：
650~700 parts of purified water is taken, under stiring, sequentially adds vitamin B1, vitamin B2, vitamin B6, vitamin
K3, vitamin B12, vitamin C, methionine, panthenol, xylo-oligosaccharide, stirring to dissolving, you can.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100304A (en) * | 2011-01-12 | 2011-06-22 | 崔增学 | Fat-soluble vitamin nano microemulsion oral liquid and preparation method thereof |
| CN105456235A (en) * | 2015-11-20 | 2016-04-06 | 厦门金达威维生素有限公司 | High-stability and high-potency-unit vitamin A oil and preparation method thereof |
| CN106666108A (en) * | 2017-02-07 | 2017-05-17 | 佛山市正典生物技术有限公司 | Vitamin molecule microemulsion containing lysozyme and preparation method of microemulsion |
| CN107041482A (en) * | 2017-03-01 | 2017-08-15 | 广州格雷特生物科技有限公司 | Special nano combined nutrition liquid formulation of a kind of Broiler chicks and preparation method thereof |
| CN107684555A (en) * | 2017-10-27 | 2018-02-13 | 青岛天元普康生物技术有限公司 | The composition of raw materials and preparation method of a kind of B B-complex for animals, oligosaccharide nanoemulsion |
-
2018
- 2018-05-11 CN CN201810446782.XA patent/CN108576781A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102100304A (en) * | 2011-01-12 | 2011-06-22 | 崔增学 | Fat-soluble vitamin nano microemulsion oral liquid and preparation method thereof |
| CN105456235A (en) * | 2015-11-20 | 2016-04-06 | 厦门金达威维生素有限公司 | High-stability and high-potency-unit vitamin A oil and preparation method thereof |
| CN106666108A (en) * | 2017-02-07 | 2017-05-17 | 佛山市正典生物技术有限公司 | Vitamin molecule microemulsion containing lysozyme and preparation method of microemulsion |
| CN107041482A (en) * | 2017-03-01 | 2017-08-15 | 广州格雷特生物科技有限公司 | Special nano combined nutrition liquid formulation of a kind of Broiler chicks and preparation method thereof |
| CN107684555A (en) * | 2017-10-27 | 2018-02-13 | 青岛天元普康生物技术有限公司 | The composition of raw materials and preparation method of a kind of B B-complex for animals, oligosaccharide nanoemulsion |
Non-Patent Citations (2)
| Title |
|---|
| 孟胜男，等: "《药剂学》", 31 January 2016, 中国医药科技出版社 * |
| 庄越: "《实用药物制剂技术》", 31 January 1999, 人民卫生出版社 * |
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