CN108576009A - Bactericidal composition - Google Patents

Bactericidal composition Download PDF

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CN108576009A
CN108576009A CN201810733743.8A CN201810733743A CN108576009A CN 108576009 A CN108576009 A CN 108576009A CN 201810733743 A CN201810733743 A CN 201810733743A CN 108576009 A CN108576009 A CN 108576009A
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fluorine
copper
formula
azoles
compound
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王礼文
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Guangdong Zhongxun Agri Science Corp
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Guangdong Zhongxun Agri Science Corp
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/34—Nitriles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A01N59/20—Copper

Abstract

The invention discloses a kind of bactericidal compositions, contain active components A and B；Wherein A, which is selected from, has formula（

Description

Bactericidal composition
Technical field
The invention belongs to technical field of pesticide, specifically the Synergistic bactericidal composition containing active components A and B；Its Middle A is selected from compound 3- difluoromethyls-N- (the fluoro- 1,1,3- trimethyls -4- indanyls of 7-) -1- methyl -4- pyrroles with formula (I) Azoles formamide, B are selected from bromothalonil, benziothiazolinone, zinc thiazole, Zhongshengmycin, kasugarnycin, tetramycin, 2-cyano-3-amino-3-phenylancryic acetate, fluorobenzene ether acyl Amine, fluorine ether bacterium amide, fluorine azoles bacterium acyl azanol, hexamethylene, fluorine chlorine ether bacterium azoles, tricyclazole, copper 8-hydroxyquinolinate, thiophene are gloomy The mass fraction ratio of one kind in copper, nonylphenolsulfonate copper, A and B are 50:1~1:50.
Technical background
Compound 3- difluoromethyls-N- (the fluoro- 1,1,3- trimethyls -4- indanyls of 7-) -1- methyl -4- pyrazoles of formula (I) Formamide is known compound, CN103502220B and CN104602523B about its related record, CN103502220B The compound racemic mixture ((I)-RS), non-enantiomer mixture, part of formula (I) are described with CN104602523B Mixture (such as (I)-R of separation8S2Representing has molar ratio R：S=8:Formula (I) compound of 2 enantiomter R and S, (I)-R9S1Representing has molar ratio R：S=9:Formula (I) compound of 1 enantiomter R and S), single optical isomer And/or form and its work of single diastereoisomer (as (I)-R represents formula (I) compound of 99.99% weight % of ＞) Property feature.
Compound 3- difluoromethyls-N- (the fluoro- 1,1,3- trimethyls -4- indanyls of 7-) -1- methyl -4- pyrazoles of formula (I) Formamide structural formula is as follows：
Compound 3- difluoromethyls-N- (the fluoro- 1,1,3- trimethyls -4- indanyls of 7-) -1- methyl -4- pyrazoles of formula (I) Formamide can be prevented by the kind of Erysiphe (Erysiphe), the kind of Rhizoctonia (Rhizoctonia), Sphaerotheca (Sphaerotheca) kind, the kind of Podosphaera (Podosphaera), the kind of Uncinula (Uncinula), grape The kind of spore category (Botrytis), the kind of Alternaria (Alaternaria), the kind of Fusarium (Fusarium), rice blast pears spore Mould (Pyricularia oryzae), the kind of sclerotium (Sclerotium), the kind of Colletotrichum (Colletotrichum), The kind of Venturia (Venturia), crop disease caused by the kind of Sclerotinia (Sclerotinia) or other pathogens draw The crop disease risen.
Fluorine chlorine ether bacterium azoles (mefentrifluconazole) is the triazole bactericidal agent of BASF exploitation, has wide spectrum, height Effect, interior suction have and root out and protective effect, show excellent biological property, are expected to become the important work of efficiently control disease Tool, and be the new product that BASF has an epoch-marking significance by for slowing down the resistance development of fungicide.Studies have shown that chlorine fluorine Ether bacterium azoles has outstanding bioactivity to many refractory fungal diseases, is suitable for many field crops and spy in world wide Kind crop, such as corn, cereal, soybean and industrial crops fluorine chlorine ether bacterium azoles structural formula are as follows：
Bromothalonil, ISO common name bromothalonil, chemical formula C6H6Br2N2, chemical name 1,2'- bis- bromo- 2,4- Dicyanobutane；Bromothalonil is a kind of wide spectrum, low toxicity, mould proof, algae-killing bactericidal agent, can inhibit and root out bacterium, fungi and algae Growth, have preferable control effect to corps diseases, especially have special efficacy to anthracnose.
Tricyclazole (Tricyclazole) is prevention rice blast bactericide specially, belongs to thiazoles (triazole type), and sterilization is made It is mainly to inhibit the formation of attachment spore melanin with mechanism, to inhibit spore germination and attachment spore to be formed, germ is prevented to invade people With the generation for reducing magnaporthe grisea spore, CN 102037980B report toxicity of the tricyclazole to rice blast.
2-cyano-3-amino-3-phenylancryic acetate, category 2- cyanoacrylate fungicide, the compound category cyanoacrylate, efficient, micro- poison, It is wide spectrum, low-residual, environmentally friendly, there is protection and therapeutic effect to the plant disease caused by sickle-like bacteria, can be applied to prevent Control wheat scab caused by sickle-like bacteria, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blight etc., cyanogen alkene Bacterium ester can prevent wheat scab volume increase while reduce wheatear grain in toxin (DON, deoxynivalenol, Also known as vomitoxin) content, improves wheat quality.
Zinc thiazole, its chemical name is 2- amino -5- sulfydryls -1,3,4- thiadiazoles zinc, and the structure of zinc thiazole is by two bases Group's composition sterilization, first, thiazolyl group, no inhibition on bacteria outside the plant, but be efficient treatment in plant Agent, in the plant's holey catheter, bacterium is severely damaged for medicament, and cell wall is thinning then to disintegrate, and leads to the dead of bacterium It dies；Second is that zinc ion, has the function of not only antifungal but also bactericidal, on the zinc ion in medicament and pathogen cell membrane surface Cationic (H+, K+ etc.) is exchanged, and causes the protein coagulating on germ cell film to kill germ, part zinc ion penetrates into disease Opportunistic pathogen is intracellular, is combined with certain enzymes, its activity is influenced, and leads to dysfunction, germ thus failure death；In two groups Under collective effect, kill that germ is more thorough, and control effect is more preferable, controlling object is more extensive.
Benziothiazolinone (benziothiazolinone) belongs to isothiazole heterocyclic compound, and mechanism of action is：With bacterium, mould The anion binding of the cell membrane surface of bacterium is reacted with sulfydryl, the synthesis system of protein and cell membrane is destroyed, to inhibit Bacterium, mould breeding, interfere pathogen cell metabolism, make its physiologic derangement, cause pathogen dead.The compound is to agriculture The diseases such as rot disease, canker, anthracnose, scab, leaf spot, downy mildew on crop have good control effect, CN 104041508B reports indoor virulence activity of the benziothiazolinone to citrus anthracnose bacterium.
Zhongshengmycin, english common name Zhongshengmycin are a kind of novel agricultural antibiotic, are by lilac grey The antibiotic that the mutation of streptomycete Hainan generates belongs to N- glycoside alkali water-soluble substances, is a kind of protectiveness that fungicidal spectrum is wider Fungicide, have tag, osmosis.
Poly hexamethylene biguanide is cationic germicide, in agriculture field application, can be adsorbed in bacterial cell table rapidly Face, fast-attack destroy cytoplasma membrane, so that endochylema composition is leaked, to reach best sterilization and disinfection effect, by pathogenic bacteria, disease Poison is pulled the grass up by its roots.Common its derivative such as hexamethylene.
Containing there are many antibiotic, wherein macrolide tetraene antibiotic, prevention bacteriosises in tetramycin preparation；Peptide pyrimidine Ucleotides antibiotic prevents fungal disease；Nitrogen heterocyclic ring aromatic derivant antibiotic improves crop immunity, When crop cauline leaf is overtaken by a storm, friction mutually causes wound and germ to enter important channel, and tetramycin has interior suction Bacteriostatic activity prevents germ from invading and extend.
Fluorobenzene ether amide (exploitation code name：Y13149 it is) novel succinate dehydrogenase inhibitors (SDHI), to rice banded sclerotial blight Disease has remarkable preventive effect, while having efficient sterilizing activity to powdery mildew, the late blight of potato.Fluorobenzene ether amide is passed with interior suction The property led, and have the characteristics that resistance to rainwater shower, dosage low (5~7 grams/acre), (200,000 yuan/ton of ＜) at low cost, preventive effect and at Originally it is substantially better than similar product thifluzamide.Fluorobenzene ether amide Chinese Patent Application No. 201310502473.7, International PCT/ CN2013/089220。
Fluorine ether bacterium amide (exploitation code name：LH-2010A), which is also succinate dehydrogenase inhibitors.In July, 2015 30, it is water-dispersed that Shandong United Pesticide Industry Co., Ltd. achieves 98% fluorine ether bacterium amide active compound, 50% fluorine ether bacterium amide The interim registration of 3 products such as granula and 40% fluorine ether hexaconazole suspending agent.Fluorine ether bacterium amide is China's independent research and head The SDHI series bactericidal agents of a listing.
Fluorine azoles bacterium acyl azanol (pydiflumetofen) is the pyrazol acid amide sterilization for being found by Syngenta, developing and producing Agent, succinate dehydrogenase inhibitors.Fluorine azoles bacterium acyl azanol efficiently, wide spectrum, be suitable for cereal, corn and soybean, rape, vegetables and Special crop etc. prevents many diseases including gray mold, brown spot, leaf spot, sclerotiniose, powdery mildew, head blight etc..
The gloomy copper of thiophene：Chemical name is bis- (1,3,4 thiadiazoles of the 2- amino -5- sulfydryls) copper of N, N- methylene -, belongs to organic copper class Fungicide is made of thiazole and copper ion, has double sterilization mechanism.Thiazole has interior suction and therapeutic effect to plant, to thin Bacterium venereal disease opportunistic pathogen has special efficacy, has limited effect to fungi；Copper ion has prevention and protective effect, to bacterial disease Have the effect of certain.Two group collective effects, more preferable to the control effect of bacterial disease, fungicidal spectrum is wider, when holding effect Between it is longer, sterilization mechanism is unique.
Tiger glue adipic acid copper (copper (succinate+glutarate+adipate))：Belong to organic copper series bactericidal agent, is The mixture of succinic acid copper, glutaric acid copper, adipic acid copper mainly passes through potassium ion, the hydrogen of copper ion and pathogen film surface The exchanges such as ion, make protein coagulating on pathogen cell membrane, at the same part copper ion penetrate into pathogen into the cell with it is certain Acid combines, and influences the activity of enzyme, plays bactericidal effect, good to cucumber bacterial angular leaf spot, citrus bacterial canker disease and other effects.
Copper 8-hydroxyquinolinate (Oxine-copper)：For organic chelated copper systemic fungicide, there are therapeutic and protective effects.To most Number bacteriosis is (such as：Bacterial septicaemia syndrome, bacterial angular leaf spot, bacterial wilt, canker, soft rot) and some fungi venereal disease evil (such as：Downy mildew, epidemic disease, spot defoliation, anthracnose etc.) there is good control effect.
Thiodiazole-copper (Thiodiazole-copper)：For organic copper class wide-spectrum bactericide, there is Uptake and translocation, prevention, guarantor The multiple actions such as shield, treatment, have preferable control effect to various bacillary and fungal disease, and Thiodiazole-copper can be in addition Microelement-supplementing copper promotes growth and development of plants, maintains photosynthesis, improves cold-resistant, the drought-resistant ability of crop.
Nonylphenolsulfonate copper (cuppric nonyl phenolsulfonate)：It is novel organic copper fungicide, belongs to broad spectrum agricultural and kill Microbial inoculum, to the downy mildew of the crops such as vegetables, fruit tree, flowers, epidemic disease, anthracnose, powdery mildew, soft rot, bacterial angular leaf spot Etc. diseases have excellent control effect, also there is certain inhibiting effect, CN 102626099B to report nonyl bacterium to plant virus Toxicity of the copper to powdery mildew of cucumber.
Fusarium (Fusarium) pathogen causes various plant diseases, Fusorium moniliforme Sheldon (Fusarium extensively Moniliforme Sheld) cause bakanae disease of rice, F.graminearum schw (Fusarium graminearun Schaabe) to cause small Wheat head blight, fusarium oxysporum (Fusarium axysporum) cause various crop droop such as fusarium oxysporum watermelon transformant to draw Play watermelon blight, fusarium oxysporum cucumber transformant causes cucumber fusarium axysporum, Fusarium oxysporum Cuba transformant to cause banana withered Disease of withering etc..Wheat scab caused by F.graminearum schw (Fusarium graminearun Schaabe).
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of not cross resistance It is a good solution to carry out controlling plant diseases；But it according to the research of Phillips McDougall companies, compares In 2005-2008 years, between 2010-2014 years, find, the average R＆D costs of 1 pesticide activity component of exploitation and registration 30,000,000 dollars are increased, increases 11.7% in other words, up to 2.86 hundred million dollars.And between 2005-2008 years, agricultural chemicals research and development Average unit cost be 2.56 hundred million dollars, increased 39% compared with 2000；Average R＆D costs in 2000 are 1.84 hundred million dollars, compared with Nineteen ninety-five increases 21%, while the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
Invention content
The present invention provides a kind of Synergistic bactericidal composition, A is mixed with B to caused by target pathogen or target pathogen Crop disease has synergistic effect, and then reduces Pesticide use amount, realizes the target that pesticide reduction uses.
The invention is realized by the following technical scheme：
Bactericidal composition contains active components A and B；Wherein A is selected from the compound 3- difluoromethyls-N- with formula (I) (fluoro- 1,1,3- trimethyl -4- indanyls of 7-) -1- methyl -4- pyrazolecarboxamides, B selected from bromothalonil, benziothiazolinone, zinc thiazole, in Raw rhzomorph, kasugarnycin, tetramycin, 2-cyano-3-amino-3-phenylancryic acetate, fluorobenzene ether amide, fluorine ether bacterium amide, fluorine azoles bacterium acyl azanol, polyhexamethylene One kind in biguanide hydrochloride, fluorine chlorine ether bacterium azoles, tricyclazole, copper 8-hydroxyquinolinate, the gloomy copper of thiophene, nonylphenolsulfonate copper, the mass fraction ratio of A and B It is 50:1~1:50；The mass fraction ratio of preferred A and B is 30:1~1:30, the mass fraction of further preferred A and B Ratio is 20:1~1:20.
The compound with formula (I) be racemic mixture or with one of enantiomter enrichment mixture or with One of two kinds of the enantiomers R or S of 99.99% weight % of ＞.
The composition, is selected from：C1：(I)-RS+ bromothalonils；C2：(I)-RS+ benziothiazolinone；C3：(I)-RS+ zinc thiazoles； C4：(I)-RS+ Zhongshengmycins；C5：(I)-RS+ kasugarnycin；C6：(I)-RS+ 2-cyano-3-amino-3-phenylancryic acetates；C7：(I)-RS+ fluorobenzene ether acyl Amine；C8：(I)-RS+ fluorine ether bacterium amide；C9：(I)-RS+ tetramycins；C10：(I)-RS+ hexamethylenes；C11： (I)-RS+ fluorine azoles bacterium acyl azanol；C12：(I)-RS+ fluorine chlorine ethers bacterium azoles；C13：(I)-RS+ copper 8-hydroxyquinolinates；C14：(I)-RS+ thiophenes are gloomy Copper；C15：(I)-RS+ nonylphenolsulfonate coppers；C16：(I)-RS+ tricyclazoles；C17：(I)-R+ bromothalonils；C18：(I)-R+ benziothiazolinone；C19： (I)-R+ zinc thiazoles；C20：(I)-R+ Zhongshengmycins；C21：(I)-R+ kasugarnycin；C22：(I)-R+ 2-cyano-3-amino-3-phenylancryic acetates；C23： (I)-R+ fluorobenzene ether amide；C24：(I)-R+ fluorine ether bacterium amide；C25：(I)-R+ tetramycins；C26：(I)-R+ polyhexamethylenes are double Guanidine hydrochloride；C27：(I)-R+ fluorine azoles bacterium acyl azanol；C28：(I)-R+ fluorine chlorine ethers bacterium azoles；C29：(I)-R+ tricyclazoles；C30： (I)-R+ copper 8-hydroxyquinolinates；C31：(I) the gloomy copper of-R+ thiophenes；C32：(I)-R+ nonylphenolsulfonate coppers；C33：(I)-R8S2+ fluorine chlorine ether bacterium azoles；C34： (I)-R8S2+ bromothalonil；C35：(I)-R8S2+ 2-cyano-3-amino-3-phenylancryic acetate；C36：(I)-R8S2+ benziothiazolinone；C37：(I)-R8S2+ zinc thiazole； C38：(I)-R8S2+ copper 8-hydroxyquinolinate；C39：(I)-R8S2+ hexamethylene；C40：(I)-R8S2+ tricyclazole；C41： (I)-R8S2+ kasugarnycin；C42：(I)-R9S1+ fluorine chlorine ether bacterium azoles；C43：(I)-R9S1+ tricyclazole；C44：(I)-R9S1+ bromine bacterium Nitrile；C45：(I)-R9S1+ 2-cyano-3-amino-3-phenylancryic acetate；C46：(I)-R9S1+ benziothiazolinone；C47：(I)-R9S1+ zinc thiazole；C48：(I)-R9S1+ quinoline Quinoline copper；C49：(I)-R9S1+ hexamethylene；C50：(I)-R9S1+ kasugarnycin；Other than formula (I)-RS is represented Formula (I) compound of racemic mixture form, formula (I)-R8S2Representing has molar ratio R：S=8:2 enantiomter R's and S Formula (I) compound, formula (I)-R9S1Representing has molar ratio R：S=9:Formula (I) compound of 1 enantiomter R and S, formula (I)-R represents formula (I) compound of 99.99% weight % of ＞.
The composition is for preventing by the purposes in the fungus-caused crop disease of pathogen.
The crop disease is by the kind of Erysiphe (Erysiphe), the kind of Rhizoctonia (Rhizoctonia), monofilament shell Belong to the kind of (Sphaerotheca), the kind of Podosphaera (Podosphaera), the kind of Uncinula (Uncinula), Portugal The kind of grape spore category (Botrytis), the kind of Alternaria (Alaternaria), the kind of Fusarium (Fusarium), rice blast pears Spore mould (Pyricularia oryzae), the kind of sclerotium (Sclerotium), Colletotrichum (Colletotrichum) Kind, the kind of Venturia (Venturia), the kind of Sclerotinia (Sclerotinia), which infects, to be caused or is infected by other pathogens Cause.
The crop includes that crop is selected from apple tree, pear tree, peach, grapevine, citrus fruit, mango, jujube tree, litchi It is branch tree, longan, tea tree, blueberry tree, garden crop, melon, vegetables, oil-produced vegetable, cereal crops, potato, tobacco, sweet Sugarcane, cotton, beet, coffee, cocoa, carambola, cherry, Japanese plum, strawberry or other crops.
The composition can be used for controlling the plant pathogenic fungi in crop comprising at one of plant to be protected Or it is applied on multiple positions and/or before seed sowing on the seed of the plant and/or in the ground of the plant growth The composition of effective dose.
The microbicide compositions are added auxiliary agent and excipients and aqueous suspension agent, dispersible are made by certain technological means The agriculturally common dosage form such as oil-suspending agent, water dispersible granules, seed treatment suspending agent.
The dosage form of water dispersible granule weight percent group becomes：Active components A 0.01~70%, active constituent B 0.01~70%, dispersant 0.1~12%, disintegrant 0.1~12%, wetting agent 0.1~5%, solid carrier complements to 100%.Specifically production stage is：Active constituent and other auxiliary agents are uniformly mixed, crushed with micro jet, through pinching It closes, is then added in fluidized-bed granulation dryer and is granulated, dries, sieve, the water-dispersed of corresponding weight percentage is made Granula.
The aqueous suspension agent dosage form weight percent group becomes：Active components A 0.01~45%, active constituent B 0.01 ~45%, active constituent total content be not more than 50%, dispersant 0.2~19%, wetting agent 0.2~12%, thickener 0.1~ 3%, antifreezing agent 0.1~5%, deionized water carrier complement to 100%.Specifically production stage is：By active constituent and other help Agent mixes, and after being sanded in high speed shear dispersion, sand mill, high dispersive, the suspension system of stabilization, system are formed in water-medium Obtain the suspending agent of corresponding weight percentage.
The dispersible oil-suspending agent dosage form weight percent group becomes：Active components A 0.01~45%, active constituent B 0.01~45%, active constituent total content are not more than 50%, dispersant 0.2~19%, wetting agent 0.2~12%, thickener 0.1~3%, antifreezing agent 0.1~5%, oiliness carrier carrier complement to 100%.Specifically production stage is：By active constituent and its Its auxiliary agent mixes, and after being sanded in high speed shear dispersion, sand mill, the suspended substance of high dispersive, stabilization is formed in oil is medium The suspending agent of corresponding weight percentage is made in system.
The seed treatment suspending agent dosage form weight percent group becomes：Active components A 0.01~45%, active constituent B 0.01~45%, active constituent total content are not more than 50%, dispersant 0.1~15%, wetting agent 0.1-15%, thickener 0.1~2%, film forming agent 0.1~15%, colorant 0.1~2%, special auxiliary element 0.1~15%, deionized water carrier are mended Enough to 100%.Specifically production stage is：Active constituent and other auxiliary agents are mixed, through being sanded in high speed shear dispersion, sand mill Afterwards, high dispersive, the suspension system of stabilization are formed in water-medium, and the suspending agent of corresponding weight percentage is made.
The film forming agent can be film forming agent 853, Arabic gum, animal glue, pectin, xanthans, methylcellulose, second Base cellulose, sodium carboxymethylcellulose, hydroxypropyl cellulose, sodium alginate, polyvinyl alcohol, polyethylene glycol, polyvinylpyrrolidine Ketone, polyacrylamide, Sodium Polyacrylate etc..
The antifoaming agent can be one or more of silicone compound, epoxidized soybean oil, methanol, silicone oil etc..
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium, Crospovidone, chitosan, sodium alginate sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc. One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay, One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin, One or more of rosin, wood powder etc..
The water is deionized water.
The oil system medium is peanut oil, corn oil, sunflower oil, palm oil, methyl oleate, coconut oil, castor oil, dish One or more of seed oil, soybean oil, turpentine oil.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be triphenoethyl benzene phenol polyethenoxy ether phosphate, epoxychloropropane, castor oil polyoxy second One kind in alkene ether, fatty alcohol polyoxy ether, aliphatic acid polyethenoxy ether, isomery alcohol.
The dispersant can be APES formaldehyde condensation product, naphthalene sulfonate, benzene sulfonate, to methoxy Base fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fat Alcohol polyoxyethylene ether, polyethylene glycol stearate, Oleate, empgen BB, nekal, phosphorus One or more of acid esters etc..
The solvent can be solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol, n-butanol, n-octyl alcohol, positive penta Alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, ethyl acetate, methyl oleate, phthalic acid Dibutyl ester, sec-Butyl Acetate.
The present invention has the advantages that：
1, A and B combinations have the growth of the mycelia of target or caused crop disease in certain mass number proportional region There is synergistic function.
2, the composition of A and B is suitable for prevention crop disease.
Specific implementation mode
It is raw to survey embodiment
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index (ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicaments × In mixture in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments percentage composition；Co-toxicity coefficient (CTC)= [mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
Formula (I)-RS represents formula (I) compound in the form of racemic mixtures,
Formula (I)-R8S2Representing has molar ratio R：S=8:Formula (I) compound of 2 enantiomter R and S,
Formula (I)-R9S1Representing has molar ratio R：S=9:Formula (I) compound of 1 enantiomter R and S,
Formula (I)-R represents formula (I) compound of 99.99% weight % of ＞.
Table 1：(I) indoor virulence of-RS and bromothalonil to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Table 2：(I)-R surveys the indoor virulence of F.graminearum schw (Fusarium graminearun Schaabe) with bromothalonil Determine result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Bromothalonil - 2.236 22.00
(I)-R：Bromothalonil 1:1 0.331 148.64 61.00 243.67
(I)-R：Bromothalonil 1:5 0.685 71.82 35.00 205.20
Table 3：(I)-R8S2With bromothalonil to the indoor virulence of F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Table 4：(I)-R9S1With bromothalonil to the indoor virulence of F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R9S1 - 0.631 100.00
Bromothalonil - 2.236 28.22
(I)-R9S1：Bromothalonil 1:1 0.427 147.78 64.11 230.50
(I)-R9S1：Bromothalonil 1:5 0.796 79.27 40.18 197.27
Table 5：(I) indoor virulence of-RS and benziothiazolinone to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Table 6：(I)-R surveys the indoor virulence of F.graminearum schw (Fusarium graminearun Schaabe) with benziothiazolinone Determine result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Benziothiazolinone - 0.874 56.29
(I)-R：Benziothiazolinone 25:1 0.388 126.80 98.32 128.97
(I)-R：Benziothiazolinone 15:1 0.274 179.56 97.27 184.60
(I)-R：Benziothiazolinone 5:1 0.247 199.19 92.72 214.84
Table 7：(I)-R8S2With benziothiazolinone to the indoor virulence of F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R8S2 - 0.514 100.00
Benziothiazolinone - 0.874 58.81
(I)-R8S2：Benziothiazolinone 25:1 0.372 138.17 98.42 140.40
(I)-R8S2：Benziothiazolinone 15:1 0.277 185.56 97.43 190.46
(I)-R8S2：Benziothiazolinone 5:1 0.248 207.26 93.14 222.54
Table 8：(I)-R9S1With benziothiazolinone to the indoor virulence of F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R9S1 - 0.631 100.00
Benziothiazolinone - 0.874 72.20
(I)-R9S1：Benziothiazolinone 25:1 0.465 135.70 98.93 137.17
(I)-R9S1：Benziothiazolinone 15:1 0.347 181.84 98.26 185.06
(I)-R9S1：Benziothiazolinone 5:1 0.322 195.96 95.37 205.48
Table 9：(I) indoor virulence of-RS and zinc thiazole to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-RS - 1.021 100.00
Zinc thiazole - 18.355 5.56
(I)-RS：Zinc thiazole 60:1 0.926 110.26 98.45 111.99
(I)-RS：Zinc thiazole 50:1 0.844 120.97 98.15 123.25
(I)-RS：Zinc thiazole 30:1 0.737 138.53 96.95 142.89
(I)-RS：Zinc thiazole 20:1 0.668 152.84 95.50 160.04
(I)-RS：Zinc thiazole 10:1 0.615 166.02 91.41 181.61
(I)-RS：Zinc thiazole 5:1 0.584 174.83 84.26 207.49
(I)-RS：Zinc thiazole 3:1 0.668 152.84 76.39 200.08
(I)-RS：Zinc thiazole 1:1 0.882 115.76 52.78 219.32
(I)-RS：Zinc thiazole 1:3 1.683 60.67 29.17 207.96
(I)-RS：Zinc thiazole 1:5 2.425 42.10 21.30 197.65
(I)-RS：Zinc thiazole 1:10 3.887 26.27 14.15 185.66
(I)-RS：Zinc thiazole 1:20 5.643 18.09 10.06 179.86
(I)-RS：Zinc thiazole 1:30 7.792 13.10 8.61 152.21
(I)-RS：Zinc thiazole 1:50 9.952 10.26 7.41 138.37
(I)-RS：Zinc thiazole 1:60 13.844 7.38 7.11 103.72
Table 10：(I) indoor virulence of-R and benziothiazolinone to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Zinc thiazole - 18.355 2.68
(I)-R：Zinc thiazole 5:1 0.315 156.19 83.78 186.43
(I)-R：Zinc thiazole 1:1 0.474 103.80 51.34 202.18
(I)-R：Zinc thiazole 1:5 1.268 38.80 18.90 205.29
Table 11：(I)-R8S2With benziothiazolinone to the interior poison of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R8S2 - 0.514 100.00
Zinc thiazole - 18.355 2.80
(I)-R8S2：Zinc thiazole 5:1 0.319 161.13 83.80 192.28
(I)-R8S2：Zinc thiazole 1:1 0.465 110.54 51.40 215.05
(I)-R8S2：Zinc thiazole 1:5 1.248 41.19 19.00 216.76
Table 12：(I)-R9S1With benziothiazolinone to the interior poison of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R9S1 - 0.631 100.00
Zinc thiazole - 18.355 3.44
(I)-R9S1：Zinc thiazole 5:1 0.382 165.18 83.91 196.87
(I)-R9S1：Zinc thiazole 1:1 0.583 108.23 51.72 209.27
(I)-R9S1：Zinc thiazole 1:5 1.522 41.46 19.53 212.27
Table 13：(I)-RS and Zhongshengmycin are malicious to the interior of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Table 14：(I)-R and Zhongshengmycin are malicious to the interior of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Zhongshengmycin - 3.095 15.90
(I)-R：Zhongshengmycin 5:1 0.351 85.98 163.02 85.98
(I)-R：Zhongshengmycin 1:1 0.432 57.95 196.54 57.95
(I)-R：Zhongshengmycin 1:5 0.944 29.91 174.23 29.91
Table 15：(I)-RS and kasugarnycin are malicious to the interior of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Table 16：(I) indoor virulence of-R and benziothiazolinone to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Kasugarnycin - 5.338 9.22
(I)-R：Kasugarnycin 15:1 0.415 118.55 94.33 125.69
(I)-R：Kasugarnycin 8:1 0.342 143.86 89.91 160.00
(I)-R：Kasugarnycin 1:1 0.514 95.72 54.61 175.28
Table 17：(I)-R9S1With benziothiazolinone to the interior poison of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R9S1 - 0.631 100.00
Kasugarnycin - 5.338 11.82
(I)-R9S1：Kasugarnycin 15:1 0.467 135.12 94.49 143.00
(I)-R9S1：Kasugarnycin 8:1 0.372 169.62 90.20 188.05
(I)-R9S1：Kasugarnycin 1:1 0.545 115.78 55.91 207.08
Table 18：(I)-RS and 2-cyano-3-amino-3-phenylancryic acetate are malicious to the interior of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Table 19：(I)-R and 2-cyano-3-amino-3-phenylancryic acetate are malicious to the interior of F.graminearum schw (Fusarium graminearun Schaabe) Power measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
2-cyano-3-amino-3-phenylancryic acetate - 0.733 67.12
(I)-R：2-cyano-3-amino-3-phenylancryic acetate 1:1 0.341 144.28 83.56 172.67
(I)-R：2-cyano-3-amino-3-phenylancryic acetate 1:7 0.411 119.71 71.23 168.06
(I)-R：2-cyano-3-amino-3-phenylancryic acetate 1:15 0.472 104.24 69.18 150.68
Table 20：(I)-R8S2With 2-cyano-3-amino-3-phenylancryic acetate to the interior of F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Table 21：(I)-R9S1With 2-cyano-3-amino-3-phenylancryic acetate to the interior of F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R9S1 - 0.631 100.00
2-cyano-3-amino-3-phenylancryic acetate - 0.733 86.08
(I)-R9S1：2-cyano-3-amino-3-phenylancryic acetate 1:1 0.403 156.58 93.04 168.28
(I)-R9S1：2-cyano-3-amino-3-phenylancryic acetate 1:7 0.455 138.68 87.82 157.91
(I)-R9S1：2-cyano-3-amino-3-phenylancryic acetate 1:15 0.518 121.81 86.95 140.09
Table 22：(I) interior of-RS and fluorobenzene ether amide to F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Table 23：(I) interior of-R and fluorobenzene ether amide to F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Fluorobenzene ether amide - 1.246 39.49
(I)-R：Fluorobenzene ether amide 1:1 0.427 115.22 69.74 165.21
(I)-R：Fluorobenzene ether amide 1:6 0.535 91.96 48.13 191.07
(I)-R：Fluorobenzene ether amide 1:12 0.588 83.67 44.14 189.56
Table 24：(I) interior of-RS and fluorine chlorine ether bacterium azoles to F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Table 25：(I) interior of-R and fluorine chlorine ether bacterium azoles to F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Fluorine chlorine ether bacterium azoles - 0.733 86.62
(I)-R：Fluorine chlorine ether bacterium azoles 15:1 0.312 157.69 99.16 159.02
(I)-R：Fluorine chlorine ether bacterium azoles 8:1 0.263 187.07 98.51 189.90
(I)-R：Fluorine chlorine ether bacterium azoles 2:1 0.299 164.55 95.54 172.23
(I)-R：Fluorine chlorine ether bacterium azoles 1:5 0.338 145.56 88.85 163.83
Table 26：(I)-R8S2With fluorine chlorine ether bacterium azoles to the room of F.graminearum schw (Fusarium graminearun Schaabe) Interior virulence measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R8S2 - 0.514 100.00
Fluorine chlorine ether bacterium azoles - 0.733 90.49
(I)-R8S2：Fluorine chlorine ether bacterium azoles 15:1 0.379 135.62 99.41 136.43
(I)-R8S2：Fluorine chlorine ether bacterium azoles 8:1 0.355 144.79 98.94 146.33
(I)-R8S2：Fluorine chlorine ether bacterium azoles 2:1 0.318 161.64 96.83 166.93
(I)-R8S2：Fluorine chlorine ether bacterium azoles 1:5 0.369 139.30 92.08 151.28
Table 27：(I)-R9S1With fluorine chlorine ether bacterium azoles to the room of F.graminearum schw (Fusarium graminearun Schaabe) Interior virulence measurement result.
Table 28：(I) interior of-RS and fluorine ether bacterium amide to F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-RS - 1.021 100.00
Fluorine ether bacterium amide - 1.304 78.30
(I)-RS：Fluorine ether bacterium amide 60:1 1.122 91.00 99.64 91.32
I)-RS：Fluorine ether bacterium amide 50:1 1.002 101.90 99.57 102.33
I)-RS：Fluorine ether bacterium amide 30:1 0.961 106.24 99.30 106.99
I)-RS：Fluorine ether bacterium amide 20:1 0.844 120.97 98.97 122.23
I)-RS：Fluorine ether bacterium amide 10:1 0.783 130.40 98.03 133.02
I)-RS：Fluorine ether bacterium amide 5:1 0.679 150.37 96.38 156.01
I)-RS：Fluorine ether bacterium amide 3:1 0.626 163.10 94.57 172.46
I)-RS：Fluorine ether bacterium amide 1:1 0.613 166.56 89.15 186.83
I)-RS：Fluorine ether bacterium amide 1:3 0.679 150.37 83.72 179.60
I)-RS：Fluorine ether bacterium amide 1:5 0.738 138.35 81.91 168.89
I)-RS：Fluorine ether bacterium amide 1:10 0.922 110.74 80.27 137.96
I)-RS：Fluorine ether bacterium amide 1:20 1.111 91.90 79.33 115.84
I)-RS：Fluorine ether bacterium amide 1:30 1.284 79.52 79.00 100.66
I)-RS：Fluorine ether bacterium amide 1:50 1.366 74.74 78.72 94.95
I)-RS：Fluorine ether bacterium amide 1:60 1.427 71.55 78.65 90.97
Table 29：(I) indoor virulence of-RS and copper 8-hydroxyquinolinate to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Table 30：(I) indoor virulence of-RS and the gloomy copper of thiophene to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Table 31：(I) indoor virulence of-RS and nonylphenolsulfonate copper to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-RS - 1.021 100.00
Nonylphenolsulfonate copper - 18.227 5.60
(I)-RS：Nonylphenolsulfonate copper 60:1 1.335 76.48 98.45 77.68
(I)-RS：Nonylphenolsulfonate copper 50:1 1.141 89.48 98.15 91.17
(I)-RS：Nonylphenolsulfonate copper 30:1 0.989 103.24 96.95 106.48
(I)-RS：Nonylphenolsulfonate copper 20:1 0.942 108.39 95.50 113.49
(I)-RS：Nonylphenolsulfonate copper 10:1 0.883 115.63 91.42 126.48
(I)-RS：Nonylphenolsulfonate copper 5:1 0.817 124.97 84.27 148.30
(I)-RS：Nonylphenolsulfonate copper 3:1 0.792 128.91 76.40 168.73
(I)-RS：Nonylphenolsulfonate copper 1:1 1.368 74.63 52.80 141.35
(I)-RS：Nonylphenolsulfonate copper 1:3 2.485 41.09 29.20 140.70
(I)-RS：Nonylphenolsulfonate copper 1:5 3.774 27.05 21.33 126.81
(I)-RS：Nonylphenolsulfonate copper 1:10 5.828 17.52 14.18 123.52
(I)-RS：Nonylphenolsulfonate copper 1:20 8.409 12.14 10.10 120.25
(I)-RS：Nonylphenolsulfonate copper 1:30 11.744 8.69 8.65 100.54
(I)-RS：Nonylphenolsulfonate copper 1:50 13.755 7.42 7.45 99.60
(I)-RS：Nonylphenolsulfonate copper 1:60 15.996 6.38 7.15 89.28
Table 32：(I) interior of-RS and tiger glue adipic acid copper to F.graminearum schw (Fusarium graminearun Schaabe) Toxicity test result.
Table 33：(I) indoor virulence of-RS and tetramycin to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Table 34：(I) indoor virulence of-R and tetramycin to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-R - 0.492 100.00
Tetramycin - 0.142 86.62
(I)-R：Tetramycin 20:1 0.306 160.78 111.74 143.90
(I)-R：Tetramycin 10:1 0.257 191.44 122.41 156.40
(I)-R：Tetramycin 5:1 0.176 279.55 141.08 198.15
Table 35：(I)-RS and hexamethylene (Polihexanide HCl) are to F.graminearum schw The The Toxicity Determination result of (Fusarium graminearun Schaabe).
Table 36：(I) indoor virulence of-RS and tricyclazole to F.graminearum schw (Fusarium graminearun Schaabe) Measurement result.
Table 37：(I) room of-RS and fluorine azoles bacterium acyl azanol to F.graminearum schw (Fusarium graminearun Schaabe) Interior virulence measurement result.
Reagent agent Proportioning EC50(μg/ml) ATI TTI CTC
(I)-RS - 1.021 100.00
Fluorine azoles bacterium acyl azanol - 12.664 8.06
(I)-RS：Fluorine azoles bacterium acyl azanol 60:1 0.923 110.62 98.49 112.31
(I)-RS：Fluorine azoles bacterium acyl azanol 50:1 0.813 125.58 98.20 127.89
(I)-RS：Fluorine azoles bacterium acyl azanol 30:1 0.777 131.40 97.03 135.42
(I)-RS：Fluorine azoles bacterium acyl azanol 20:1 0.659 154.93 95.62 162.03
(I)-RS：Fluorine azoles bacterium acyl azanol 10:1 0.622 164.15 91.64 179.12
(I)-RS：Fluorine azoles bacterium acyl azanol 5:1 0.615 166.02 84.68 196.06
(I)-RS：Fluorine azoles bacterium acyl azanol 3:1 0.728 140.25 77.02 182.10
(I)-RS：Fluorine azoles bacterium acyl azanol 1:1 0.980 104.18 54.03 192.82
(I)-RS：Fluorine azoles bacterium acyl azanol 1:3 1.942 52.57 31.05 169.34
(I)-RS：Fluorine azoles bacterium acyl azanol 1:5 2.785 36.66 23.39 156.77
(I)-RS：Fluorine azoles bacterium acyl azanol 1:10 4.668 21.87 16.42 133.20
(I)-RS：Fluorine azoles bacterium acyl azanol 1:20 6.544 15.60 12.44 125.42
(I)-RS：Fluorine azoles bacterium acyl azanol 1:30 7.516 13.58 11.03 123.18
(I)-RS：Fluorine azoles bacterium acyl azanol 1:50 8.895 11.48 9.86 116.36
(I)-RS：Fluorine azoles bacterium acyl azanol 1:60 10.666 9.57 9.57 100.03
Table 38：(I) room of-R and fluorine azoles bacterium acyl azanol to F.graminearum schw (Fusarium graminearun Schaabe) Interior virulence measurement result.
Example of formulations
It is white to weigh 25% bromothalonil, 5% (I)-RS, 7% sodium lignin sulfonate, 8% sodium polycarboxylate, 3% tea seed cake powder, surplus Carbon black.Above-mentioned raw materials are uniformly mixed in mixed cylinder, and by extruding, granulation, drying, and 25% bromine bacterium is made in screened step Nitrile 5% (I)-RS water dispersible granules.
5% (I)-RS, 15% 2-cyano-3-amino-3-phenylancryic acetate, 9%EO-PO block polymers, 3% glycerine, 2% urea, addition is taken to go Ionized water complements to 100%, and active constituent and other auxiliary agents are mixed, after being sanded in high speed shear dispersion, sand mill, in water It is to form high dispersive, the suspension system of stabilization in medium, obtains 5% (I)-RS15% 2-cyano-3-amino-3-phenylancryic acetate aqueous suspension agents.
20% (I)-R, 10% fluorine chlorine ether bacterium azoles, 8% castor oil polyoxyethylene ether, 5% glycerine, 1% urea are taken, is added Deionized water complements to 100%, and active constituent and other auxiliary agents are mixed, after being sanded in high speed shear dispersion, sand mill, High dispersive, the suspension system of stabilization are formed in water-medium, obtain 10% fluorine chlorine ether bacterium azoles 20% (I)-R aqueous suspension agents.
Take 8% (I)-RS, 24% tricyclazole, 10% sodium lignin sulfonate, 2% fatty alcohol polyoxyethylene ether, 3% 2 sweet Alcohol is added deionized water and complements to 100%, active constituent and other auxiliary agents are mixed, through sand in high speed shear dispersion, sand mill After mill, high dispersive, the suspension system of stabilization are formed in water-medium, obtains 24% tricyclazole 8% (I)-RS aqueous suspension agents.
Take 8% (I)-RS, 24% tricyclazole, 10% sodium lignin sulfonate, 2% fatty alcohol polyoxyethylene ether, 3% 2 sweet Alcohol is added deionized water and complements to 100%, active constituent and other auxiliary agents are mixed, through sand in high speed shear dispersion, sand mill After mill, high dispersive, the suspension system of stabilization are formed in water-medium, obtains 24% tricyclazole 8% (I)-RS aqueous suspension agents.
Take 5% (I)-RS, 5% kasugarnycin, 5% sodium lignin sulfonate, 5% castor oil polyoxyethylene ether, 3% the third three Alcohol is added deionized water and complements to 100%, active constituent and other auxiliary agents are mixed, through sand in high speed shear dispersion, sand mill After mill, high dispersive, the suspension system of stabilization are formed in water-medium, obtains 5% kasugarnycin 5% (I)-RS aqueous suspensions Agent.
8% (I)-RS, 24% fluorine azoles bacterium acyl azanol, 8% sodium lignin sulfonate, 4% sodium butylnaphthalenesulfonate, 2% urea are taken, Deionized water is added and complements to 100%, active constituent and other auxiliary agents are mixed, through being sanded in high speed shear dispersion, sand mill Afterwards, high dispersive, the suspension system of stabilization are formed in water-medium, and it is outstanding to obtain 24% fluorine azoles bacterium acyl azanol, 8% (I)-RS water Floating agent.
4% (I)-RS, 4% benziothiazolinone, 4% sodium lignin sulfonate, 2% sodium naphthalene sulfonate, 1% urea are taken, deionization is added Water complements to 100%, and active constituent and other auxiliary agents are mixed, and after being sanded in high speed shear dispersion, sand mill, is situated between in water system High dispersive, the suspension system of stabilization are formed in matter, obtain 4% benziothiazolinone 4% (I)-RS aqueous suspension agents.
Application Example
Table 39 5% (I)-RS15% 2-cyano-3-amino-3-phenylancryic acetates aqueous suspension agent, 24% fluorine azoles bacterium acyl azanol, 8% (I)-RS are for preventing Wheat scab, wheat powdery mildew, per hectare are watered 450 liters of sprayings, investigate within 20 days after medicine.
Table 40 25% bromothalonil 5% (I)-RS water dispersible granules are for preventing watermelon anthrax, powdery mildew of cucumber, often Hectare is watered 450 liters of sprayings, investigates within 20 days after medicine.
41 10% fluorine chlorine ether bacterium azoles of table, 20% (I)-R aqueous suspension agents, 4% benziothiazolinone 4% (I)-RS aqueous suspension agents are for preventing Graw mold of tomato, Leaf Spot Caused by Corynespora cassiicola on Cucumber are controlled, per hectare is watered 450 liters of sprayings, investigates within 20 days after medicine.
Table 42 24% tricyclazole 8% (I)-RS aqueous suspension agents are for preventing rice blast, rice sheath blight disease, per hectare 450 liters of sprayings are watered, are investigated within 20 days after medicine.
43 24% tricyclazole of table, 8% (I)-RS aqueous suspension agents, 5% kasugarnycin 5% (I)-RS aqueous suspension agents are for preventing Rice blast, rice sheath blight disease, per hectare are watered 450 liters of sprayings, are investigated within 20 days after investigation medicine within 20 days after medicine.

Claims (13)

1. bactericidal composition, it is characterised in that contain active components A and B；Wherein A, which is selected from, has formula（）Compound 3- difluoros Methyl-N-（The fluoro- 1,1,3- trimethyls -4- indanyls of 7-）- 1- methyl -4- pyrazolecarboxamides, B are selected from bromothalonil, benziothiazolinone, thiophene Azoles zinc, kasugarnycin, tetramycin, 2-cyano-3-amino-3-phenylancryic acetate, fluorobenzene ether amide, fluorine ether bacterium amide, fluorine azoles bacterium acyl azanol, gathers Zhongshengmycin One kind in hexamethylene bis guanidine hydrochloride, fluorine chlorine ether bacterium azoles, tricyclazole, copper 8-hydroxyquinolinate, the gloomy copper of thiophene, nonylphenolsulfonate copper, the quality of A and B Number ratio is 50:1~1:50.
2. composition according to claim 1, it is characterised in that：The mass fraction ratio of A and B is 30:1~1:30.
3. composition according to claim 2, it is characterised in that：The mass fraction ratio of A and B is 20:1~1:20.
4. according to the composition described in claims 1 to 3 any one, wherein described have formula（）Compound be racemic Mixture.
5. according to the composition described in claims 1 to 3 any one, wherein described have formula（）Compound be selected from：
With one of enantiomter be enriched with mixture,
With one of two kinds of the enantiomers R or S of 99.99% weight % of ＞.
6. composition according to claim 5, wherein described have formula（）Compound be with the mixed of enantiomer R enrichment Close object.
7. composition according to claim 5, wherein described have formula（）Compound be with 99.99% weight % of ＞ Enantiomer R.
8. according to the composition described in claims 1 to 3 any one, it is selected from：
C1：（）- RS+ bromothalonils；
C2：（）- RS+ benziothiazolinone；
C3：（）- RS+ zinc thiazoles；
C4：（）- RS+ Zhongshengmycins；
C5：（）- RS+ kasugarnycin；
C6：（）- RS+ 2-cyano-3-amino-3-phenylancryic acetates；
C7：（）- RS+ fluorobenzene ether amides；
C8：（）- RS+ fluorine ether bacterium amides；
C9：（）- RS+ tetramycins；
C10：（）- RS+ hexamethylenes；
C11：（）- RS+ fluorine azoles bacterium acyl azanols；
C12：（）- RS+ fluorine chlorine ether bacterium azoles；
C13：（）- RS+ copper 8-hydroxyquinolinates；
C14：（）The gloomy copper of-RS+ thiophenes；
C15：（）- RS+ nonylphenolsulfonate coppers；
C16：（）- RS+ tricyclazoles；
C17：（）- R+ bromothalonils；
C18：（）- R+ benziothiazolinone；
C19：（）- R+ zinc thiazoles；
C20：（）- R+ Zhongshengmycins；
C21：（）- R+ kasugarnycin；
C22：（）- R+ 2-cyano-3-amino-3-phenylancryic acetates；
C23：（）- R+ fluorobenzene ether amides；
C24：（）- R+ fluorine ether bacterium amides；
C25：（）- R+ tetramycins；
C26：（）- R+ hexamethylenes；
C27：（）- R+ fluorine azoles bacterium acyl azanols；
C28：（）- R+ fluorine chlorine ether bacterium azoles；
C29：（）- R+ tricyclazoles；
C30：（）- R+ copper 8-hydroxyquinolinates；
C31：（）The gloomy copper of-R+ thiophenes；
C32：（）- R+ nonylphenolsulfonate coppers；
C33：（）-R8S2+ fluorine chlorine ether bacterium azoles；
C34：（）-R8S2+ bromothalonil；
C35：（）-R8S2+ 2-cyano-3-amino-3-phenylancryic acetate；
C36：（）-R8S2+ benziothiazolinone；
C37：（）-R8S2+ zinc thiazole；
C38：（）-R8S2+ copper 8-hydroxyquinolinate；
C39：（）-R8S2+ hexamethylene；
C40：（）-R8S2+ tricyclazole；
C41：（）-R8S2+ kasugarnycin；
C42：（）-R9S1+ fluorine chlorine ether bacterium azoles；
C43：（）-R9S1+ tricyclazole；
C44：（）-R9S1+ bromothalonil；
C45：（）-R9S1+ 2-cyano-3-amino-3-phenylancryic acetate；
C46：（）-R9S1+ benziothiazolinone；
C47：（）-R9S1+ zinc thiazole；
C48：（）-R9S1+ copper 8-hydroxyquinolinate；
C49：（）-R9S1+ hexamethylene；
C50：（）-R9S1+ kasugarnycin；
Wherein：
Formula（）- RS represents formula in the form of racemic mixtures（）Compound,
Formula（）-R8S2Representing has molar ratio R：S=8:The formula of 2 enantiomter R and S（）Compound,
Formula（）-R9S1Representing has molar ratio R：S=9:The formula of 1 enantiomter R and S（）Compound,
Formula（）- R represents the formula of 99.99% weight % of ＞（）Compound.
9. according to the composition described in claims 1 to 3 any one, it is characterised in that：The composition by active constituent Aqueous suspension agent, dispersible oil-suspending agent, water dispersible granules, seed treatment suspending agent is made with auxiliary material.
10. composition as described in any one of claim 1 to 9 is for preventing by the fungus-caused crop disease of pathogen Purposes.
11. the purposes of composition according to claim 10, wherein the pathogen fungi is selected from following：Erysiphe （Erysiphe）Kind, Rhizoctonia（Rhizoctonia）Kind, Sphaerotheca（Sphaerotheca）Kind, cross hair list capsule Shell category（Podosphaera）Kind, Uncinula（Uncinula）Kind, Botrytis（Botrytis）Kind, Alternaria （Alaternaria）Kind, Fusarium（Fusarium）Kind, rice blast pears spore it is mould（Pyricularia oryzae）, small nut Pseudomonas（Sclerotium）Kind, Colletotrichum（Colletotrichum）Kind, Venturia（Venturia）Kind, nuclear disk Pseudomonas（Sclerotinia）Kind.
12. according to the purposes of the combination of claim 10 or 11, wherein crop be selected from apple tree, pear tree, peach, grapevine, Citrus fruit, mango, jujube tree, litchi, longan, tea tree, blueberry tree, garden crop, melon, vegetables, oil-produced vegetable, Cereal crops, potato, tobacco, sugarcane, cotton, beet, coffee, cocoa, carambola, cherry, Japanese plum, strawberry.
13. the method for controlling the plant pathogenic fungi in crop comprising at one or more positions of plant to be protected Above and/or before seed sowing on the seed of the plant and/or in the ground of the plant growth apply effective dose The composition of at least one any one claim according to claim 1-9.
CN201810733743.8A 2018-07-06 2018-07-06 Bactericidal composition Pending CN108576009A (en)

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CN108719300A (en) * 2017-04-20 2018-11-02 江苏龙灯化学有限公司 A kind of bactericidal composition

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CN104602523A (en) * 2012-06-15 2015-05-06 I-F产品协作基金会 Synergistic compositions for the protection of agrarian crops and the use thereof
CN106070231A (en) * 2016-06-30 2016-11-09 京博农化科技股份有限公司 A kind of containing 2-cyano-3-amino-3-phenylancryic acetate with the bactericidal composition of pyrazoles indanyl Methanamide
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