CN108570080A - A kind of preparation method of Paeoniflorin - Google Patents
A kind of preparation method of Paeoniflorin Download PDFInfo
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- CN108570080A CN108570080A CN201710137213.2A CN201710137213A CN108570080A CN 108570080 A CN108570080 A CN 108570080A CN 201710137213 A CN201710137213 A CN 201710137213A CN 108570080 A CN108570080 A CN 108570080A
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- paeoniflorin
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- cavitation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention relates to a kind of preparation methods of Paeoniflorin, and in particular to a method of Paeoniflorin in Chinese herbaceous peony is extracted using multiple-effect broken wall cryotronl collimation method.Its processing step includes：Chinese herbaceous peony is dried in the shade, is crushed, by raw material by ultra high pressure extraction device, is extracted with entering percussion flow after the pressure extraction of 50MPa, carries out cavitation subsequently into cavitation extraction device, 100% cell wall passes through supersonic jet extractor after dismembering；Extracting solution is entered into film after press filtration drainage piece-rate system and is combined multistage film separation system, enters resin column piece-rate system later, obtains separating liquid；By separating liquid through film combination Multistage Membranes concentration systems concentration, concentrate is obtained；Gained concentrate is dried through vacuum belt-type dryer finally, obtains Paeoniflorin.The advantages that present invention has labor intensity low, and operating environment is excellent, and room temperature operation, heat-sensitive ingredients are decomposed without destruction, and color, smell and taste reservation is abundant and environmental-friendly, and circular agriculture comprehensive utilization ratio is high.
Description
Technical field
The present invention relates to a kind of preparation methods of Paeoniflorin, belong to traditional Chinese medicine extyaction field.
Background technology
Chinese herbaceous peony alias will from, from grass, be the famous herbage flower of Paeoniaceae Paeonia.According to analysis, Chinese herbaceous peony contains Paeoniflorin.
With antispastic, analgesia, promoting menstruation.It is effective to illnesss such as the abdominal pain of women, gastrospasm, dizziness, gout, diuresis.
Paeoniflorin has significant analgesia, calm, anticonvulsant action.It is frightened caused by Chinese herbaceous peony medicinal extract energy antagonism strychnine
It faints.In recent years, it has been found that contain a large amount of Paeoniflorin in natural plant peony, since its raw material Chinese herbaceous peony water source is wider, therefrom
Extraction Paeoniflorin has achieved encouraging progress.
Paeoniflorin extracts in preparation process, usually refluxing extraction, big sky resin adsorption, but these methods are retaining effectively
Ingredient, removal invalid components etc., there is energy consumptions it is big, loss of effective components is big the shortcomings of.
Invention content
The present invention be directed to the deficiencies in the prior art, it is desirable to provide a kind of high efficiency and selective, easy to operate, yield
It is high, by-product is few, can realization of industrialization the method for preparing Paeoniflorin.
Technical scheme of the present invention is carried out according to the following steps：
A. Chinese herbaceous peony is dried in the shade, is crushed, by raw material by ultra high pressure extraction device, to enter percussion flow after the pressure extraction of 50MPa
Extraction carries out cavitation subsequently into cavitation extraction device, and 100% cell wall passes through supersonic jet extractor after dismembering；
B., extracting solution is entered to film combination-multistage film separation system after press filtration drainage piece-rate system, later into resin column point
From system, separating liquid is obtained；Separating liquid is concentrated through film combination-Multistage Membranes concentration systems, obtains concentrate；
C. gained concentrate is dried through vacuum belt-type dryer, obtains Paeoniflorin.
Ultra high pressure extraction device pressure described in step a is 50MPa, power of motor 75KW, after cavitation comprehensive function,
100% cell wall is dismembered, about 20 microns of fragment, and secondary metabolite is directly contacted with solvent, is acted on and was transported without osmotic pressure
Journey, solvents counter-current extraction very high speed are nearly 10 times of velocity of sound.
Ceramic membrane permeate turbidity is less than or equal to 1 in film combination-multistage film separation system described in step b, film concentration
The pure pressure-driven of equipment concentration process, flow of inlet water 6m3/h.
Vacuum belt-type dryer drying and dehydrating ultrahigh vacuum described in step c, and starvation, rate of drying is fast, steams
Hair amount is big and good product quality.
The advantage of the invention is that：
1. the present invention handles raw material using multiple-effect broken wall cryogenic pipelines extraction method, realizes crushing, extracts step completion, while by
In entire production process without heating, produced in cryogenic pipelines, so as to effectively avoid the destruction of Paeoniflorin ingredient.
2. of the invention use multiple-effect broken wall cryogenic pipelines to extract Paeoniflorin, there is quick, efficient, recovery rate height, it is complete to protect
The advantages of staying Paeoniflorin active ingredient.
It is further illustrated the present invention below in conjunction with specific implementation mode, but the scope of protection of present invention is not limited to
In following embodiments.
Specific implementation mode：
Embodiment 1：
Chinese herbaceous peony is dried in the shade, is crushed, by raw material by ultra high pressure extraction device, to be carried into percussion flow after the pressure extraction of 40MPa
It takes, carries out cavitation subsequently into cavitation extraction device, 100% cell wall passes through supersonic jet extractor after dismembering；It will
Extracting solution enters film combination-multistage film separation system after press filtration drainage piece-rate system, enters resin column piece-rate system later, obtains
Separating liquid；Separating liquid is concentrated through film combination-Multistage Membranes concentration systems, obtains concentrate；Finally by gained concentrate through vacuum belt
Formula drier is dried, and is obtained Paeoniflorin, is detected through HPLC, purity 99.6%.
Embodiment 2：
Chinese herbaceous peony is dried in the shade, is crushed, by raw material by ultra high pressure extraction device, to be carried into percussion flow after the pressure extraction of 70MPa
It takes, carries out cavitation subsequently into cavitation extraction device, 100% cell wall passes through supersonic jet extractor after dismembering；It will
Extracting solution enters film combination-multistage film separation system after press filtration drainage piece-rate system, enters resin column piece-rate system later, obtains
Separating liquid；Separating liquid is concentrated through film combination-Multistage Membranes concentration systems, obtains concentrate；Finally by gained concentrate through vacuum belt
Formula drier is dried, and is obtained Paeoniflorin, is detected through HPLC, purity 99.5%.
Embodiment 3：
Chinese herbaceous peony is dried in the shade, is crushed, by raw material by ultra high pressure extraction device, to be carried into percussion flow after the pressure extraction of 50MPa
It takes, carries out cavitation subsequently into cavitation extraction device, 100% cell wall passes through supersonic jet extractor after dismembering；It will
Extracting solution enters film combination-multistage film separation system after press filtration drainage piece-rate system, enters resin column piece-rate system later, obtains
Separating liquid；Separating liquid is concentrated through film combination-Multistage Membranes concentration systems, obtains concentrate；Finally by gained concentrate through vacuum belt
Formula drier is dried, and is obtained Paeoniflorin, is detected through HPLC, purity 99.8%.
Claims (4)
1. a kind of preparation method of Paeoniflorin, it is characterised in that：
A. Chinese herbaceous peony is dried in the shade, is crushed, by raw material by ultra high pressure extraction device, to enter percussion flow after the pressure extraction of 50MPa
Extraction carries out cavitation subsequently into cavitation extraction device, and 100% cell wall passes through supersonic jet extractor after dismembering；
B., extracting solution is entered to film combination-multistage film separation system after press filtration drainage piece-rate system, later into resin column point
From system, separating liquid is obtained；Separating liquid is concentrated through film combination-Multistage Membranes concentration systems, obtains concentrate；
C. gained concentrate is dried through vacuum belt-type dryer, obtains Paeoniflorin.
2. a kind of preparation method of Paeoniflorin according to claim 1, which is characterized in that the super-pressure described in step a
Extractor pressure is 50MPa, power of motor 75KW, and after cavitation comprehensive function, 100% cell wall is dismembered, about 20 microns of fragment,
Secondary metabolite is directly contacted with solvent, and transport process is acted on without osmotic pressure, solvents counter-current extraction very high speed,
It is nearly 10 times of velocity of sound.
3. a kind of preparation method of Paeoniflorin according to claim 1, which is characterized in that the film combination-described in step b
Ceramic membrane permeate turbidity is less than or equal to 1 in multistage film separation system, the pure pressure-driven of film concentrator concentration process, feed water flow
Amount is 6m3/h。
4. a kind of preparation method of Paeoniflorin according to claim 1, which is characterized in that the vacuum belt described in step c
Formula drier drying and dehydrating ultrahigh vacuum, and starvation, rate of drying is fast, and evaporation capacity is big and good product quality.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710137213.2A CN108570080A (en) | 2017-03-09 | 2017-03-09 | A kind of preparation method of Paeoniflorin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710137213.2A CN108570080A (en) | 2017-03-09 | 2017-03-09 | A kind of preparation method of Paeoniflorin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108570080A true CN108570080A (en) | 2018-09-25 |
Family
ID=63577693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710137213.2A Pending CN108570080A (en) | 2017-03-09 | 2017-03-09 | A kind of preparation method of Paeoniflorin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108570080A (en) |
-
2017
- 2017-03-09 CN CN201710137213.2A patent/CN108570080A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180925 |
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| WD01 | Invention patent application deemed withdrawn after publication |