CN108553631A - It is a kind of to rule the pharmaceutical composition and preparation method for treating gastrointestinal dysfunction by law based on hot salt - Google Patents

Abstract

The present invention provides a kind of ruled by law based on hot salt to treat the pharmaceutical composition of gastrointestinal dysfunction, including sea salt and traditional Chinese medicinal components, wherein the traditional Chinese medicinal components include the ingredient of following parts by weight：5 15 parts of radix bupleuri, 5 15 parts of rhizoma zingiberis, 5 15 parts of wrinkled giant hyssop, 5 15 parts of eupatorium, 5 15 parts of Rhizoma Atractylodis Macrocephalae, 5 15 parts of cloves, 5 15 parts of the dried immature fruit of citron orange, 5 15 parts of Fructus Aurantii, 5 15 parts of Cortex Magnoliae Officinalis, 5 15 parts of fructus amomi, 5 15 parts of rhizoma atractylodis, 5 15 parts of dried orange peel, 5 15 parts of rhizoma cyperi, 5 15 parts of dalbergia wood, 5 15 parts of Radix Paeoniae Alba, 5 15 parts of Inula britannica chinensis；The weight ratio of the sea salt and traditional Chinese medicinal components is 3 10:7.Pharmaceutical composition each component scientific compatibility of the present invention, interaction, have effects that remove dampness by means of aromatics, anti-vomiting, antidiarrheal of being amusing, regulating qi-flowing for relieving pain, to alleviation gastrointestinal dysfunction related symptoms significantly.

Description

It is a kind of to rule the pharmaceutical composition and preparation method for treating gastrointestinal dysfunction by law based on hot salt

Technical field

The invention belongs to Chinese medicine preparation technical fields, relate generally to a kind of medicine ruled by law based on hot salt and treat gastrointestinal dysfunction Compositions and preparation method.

Background technology

Gastrointestinal dysfunction is a kind of gastrointestinal syndrome, and modern medicine thinks to be that dysautonomia disorder causes, In terms of main clinical manifestation is gastrointestinal tract, it is more common in exception in terms of gastrointestinal motility function, such as abdominal discomfort, abdominal pain, is vomitted at nausea Spit, abdominal distension, diarrhea, constipation etc..It is routine clinical to check if electronic gastrointestinal mirror, B ultrasound, CT examination are without organic pathological change.Stomach The cause of disease of bowel dysfunction is varied, and common disease factor has abdominal operation, wound, depression, confusion etc..Present expert is general It is the necessary pathogenic factors for causing functional disturbances of gastrointestinal tract venereal disease to become all over the excessive sensibility of abdominal viscera sensory nerve is recognized, And mesencephalic centre nervous system also assist in it the pathologic process that becomes of functional disturbances of gastrointestinal tract venereal disease.It is dynamic in all alimentary canals Although other positions are also likely to be present dynamical problem during power changes, changed with the power of colon the most notable, it may be said that stomach and intestine Dysfunction disease in road should include the emptying motion function disorder disease of all-digestive tract.Western medical treatment is mainly controlled with suiting the medicine to the illness at present Based on treatment, by alleviating spiritual neurological manifestations, nervous mental element is excluded, the medicine acted in relation to anticholinergic pharmacology is used Object restores gastrointestinal tract air emptying function to reach.But it finds that therapeutic effect is undesirable by clinical observation for many years, and takes for a long time Related drugs bring very big inconvenience to patient's life, and side effect is apparent, wastes medical resource, increases living cost.

Tcm clinical practice thinks functional disturbances of gastrointestinal tract lesion in stomach and intestine more at present, and interpretation of the cause, onset and process of an illness key is lost in transporting and transforming function of the spleen and stomach and is good for, often See simulataneous insufficiency and excessive.Empty person belongs to deficiency of spleen-QI and stomach-QI more, and real person is that wet foul smell is stagnant.Because attacking outside cold-evil, direct stimulation, feeding desorder, feed The pungent equivalent damage taste of raw food cause the imbalance of hypoactivity of spleen-YANG transportation capabilities, it is wet it is turbid in stop, mechanism of qi pent-up and cause precise and tiny not cloth pure and impure not Divide conduction mistake department.Clinic can behave as making when abdominal distention, the paddy that receives is not good enough diseases such as half congealed during stool.During a large amount of clinical observation shows Medicine, which has it, to be had a better effect, wherein Chinese medicine package method, and Gu claims medicine to press method,《The Yellow Emperor's Canon of Internal Medicine》In on the books, significant effect. Continue to use by now, which evolves into the heat therapy of Chinese medicine, especially with hot salt method it is easy to use, effect is good.

The patent application of publication number CN104623520A proposes a kind of salt packet and preparation method thereof for treating cervical spondylosis, institute It states and is filled in salt packet with crude salt, the root of Dahurain angelica, Rhizoma Chuanxiong, the root of Chinese clematis, monkshood, radix aconiti agrestis, turmeric, safflower, pueraria lobata are also equipped in the salt packet Each equivalent；Each traditional Chinese medicinal components heat in salt packet together with salt, spread at patients with cervical, have heat-therapeutic action to cervical vertebra.Publication number The patent application of CN106822273A proposes a kind of Chinese medicine composition for treating pain in the back, and the Chinese medicine composition is by following weight Raw material be formulated：Radix Angelicae Pubescentis 15-30g, Rhizoma Chuanxiong 10-25g, Radix Salviae Miltiorrhizae 15-30g, Ramulus Taxilli 25-40g, Cortex Eucommiae 10-25g, the root of bidentate achyranthes 15-30g, root of Chinese clematis 8-20g, rhizoma cibotii 8-20g, Fructus Liquidambaris 10-25g, safflower 10-25g, folium artemisiae argyi 10-25g, Caulis Spatholobi 40- 60g.The Chinese medicine composition can coordinate hot salt to apply use, treat pain in the back.

There is no the pharmaceutical compositions for being directed to gastrointestinal dysfunction for above-mentioned Traditional Chinese medicine composition formula, and rarely have in the prior art People's research is directed to the pharmaceutical formulation of gastrointestinal dysfunction based on hot salt method.

Invention content

It is secondary the purpose of the present invention is to provide a kind of quick, curative effect really for deficiencies of the prior art Act on few hot salt method treatment abdominal distension caused by gastrointestinal dysfunction, abdominal pain, the pharmaceutical composition of vomiting and diarrhoea and its preparation Method.

Another object of the present invention is to provide a kind of salt packet for ruling treatment gastrointestinal dysfunction by law based on hot salt, the salt packets Including aforementioned pharmaceutical compositions, hot compress can alleviate the related symptoms of gastrointestinal dysfunction initiation.

To achieve the above object, technical solution provided by the invention is as follows：

It is a kind of to rule the pharmaceutical composition for treating gastrointestinal dysfunction by law based on hot salt, including sea salt and traditional Chinese medicinal components, wherein institute State the ingredient that traditional Chinese medicinal components include following parts by weight：

5-15 parts of radix bupleuri, 5-15 parts of rhizoma zingiberis, 5-15 parts of wrinkled giant hyssop, 5-15 parts of eupatorium, 5-15 parts of Rhizoma Atractylodis Macrocephalae, 5-15 parts of cloves, trifoliate orange It is 5-15 parts real, 5-15 parts of Fructus Aurantii, 5-15 parts of Cortex Magnoliae Officinalis, 5-15 parts of fructus amomi, 5-15 parts of rhizoma atractylodis, 5-15 parts of dried orange peel, 5-15 parts of rhizoma cyperi, 5-15 parts of dalbergia wood, 5-15 parts of Radix Paeoniae Alba, 5-15 parts of Inula britannica chinensis；

The weight ratio of the sea salt and traditional Chinese medicinal components is 3-10:7.

Preferably, the traditional Chinese medicinal components include the ingredient of following parts by weight：5-7 parts of radix bupleuri, 5-7 parts of rhizoma zingiberis, wrinkled giant hyssop 5-7 Part, 5-7 parts of eupatorium, 5-7 parts of Rhizoma Atractylodis Macrocephalae, 5-7 parts of cloves, 5-7 parts of the dried immature fruit of citron orange, 5-7 parts of Fructus Aurantii, 5-7 parts of Cortex Magnoliae Officinalis, 5-7 parts of fructus amomi, rhizoma atractylodis 5-7 parts, 5-7 parts of dried orange peel, 5-7 parts of rhizoma cyperi, 5-7 parts of dalbergia wood, 5-7 parts of Radix Paeoniae Alba, 5-7 parts of Inula britannica chinensis；

The weight ratio of the sea salt and traditional Chinese medicinal components is 1:1.

Following basis《Chinese Pharmacopoeia》、《Dictionary of medicinal plant》And《Chinese draft》It introduces the nature and flavor of primary raw material medicine, return Through basic conditions such as, function and applications.

Radix bupleuri：Acrid flavour, hardship, cold nature, Return liver, courage, lung channel；In inducing diaphoresis, soothing the liver rising Yang.For cold, fever, fever and chills Contact, malaria, stagnation of QI due to depression of the liver, sternal rib pain, rectal prolapse, the prolapse of uterus, irregular menstruation.

Rhizoma zingiberis：Acrid flavour, property heat, returns spleen, stomach, lung channel；Middle benefit gas is by cold, recover Yang and smooth venation.It for trusted subordinate's crymodynia, vomits and diarrhoea, limb is cold Weak pulse, breathes with cough for cold time, wind-cold-dampness arthralgia, and the deficiency of yang spits, is defeated in battle, lower blood.

Wrinkled giant hyssop：Acrid flavour, slightly warm in nature, returns spleen, stomach, lung channel；It eliminates dampness with aromatics and middle preventing or arresting vomiting, delivers relieving summer-heat.For it is wet it is turbid in Resistance, the vomiting of gastral cavity ruffian, summer-heat and damp exterior syndrome, damp-warm syndrome is from the beginning of burnout of generating heat is uncomfortable in chest not relax, and cold-dampness closes heat, and abdominal pain is vomited and diarrhoea, nasosinusitis headache.

Eupatorium：Acrid flavour, mild-natured, returns spleen, stomach；Clear heat wards off dirty, dampness elimination, menstruation regulating.For experiencing summer-heat and damp, fever and chills headache is wet Accumulate in heresy, gastral cavity ruffian is not hungry, the sweet tongue of mouth is greasy, irregular menstruation.

Rhizoma Atractylodis Macrocephalae：Bitter, sweet, warm-natured, returns spleen, stomach；Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis.For spleen eating less, Abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.

Cloves：Acrid flavour, warm-natured, return lung, stomach, spleen, kidney channel；Inverse, warming kidney and enhancing yang drops in middle benefit gas.For stomach abdomen crymodynia, up-rushing gas syndrome Inverse, vomit dirty vomiting and diarrhoea and impotence in male, woman are sombre etc..

The dried immature fruit of citron orange：Bitter, pungent, sour, cold nature, returns spleen, stomach；Have the function of that relieving stagnant Qi disperse accumulation, resolving sputum dissipate ruffian.For stagnating Inside stop, feeling of fullness distending pain, weight after rush down dysentery, constipation, the resistance of phlegm stagnant gas, the obstruction of qi in the chest, accumulation of pathogens in chest, visceral organ ptosis.

Fructus Aurantii：Bitter, pungent, sour, warm-natured, converge to the spleen channel, stomach；Regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling of row.For chest and abdomen feeling of fullness distending pain, Accumulation of food in the stomach and intes tine due to indigestion, phlegm and retained fluid, gastroptosis.

Cortex Magnoliae Officinalis：Bitter, pungent, warm-natured, returns spleen, stomach, large intestine channel；Effect eliminating dampness dissolving phlegm, lower gas removes full；For in humidity hysteresis wound, Abdominal swelling and diarrhea, stagnation of QI due to dyspepsia, abdominal distention constipation, sputum cough.

Rhizoma atractylodis：Acrid flavour, hardship, warm-natured, returns spleen, stomach；It is drying damp and strengthening spleen, wind-damp dispelling, improving eyesight.For the spleen and stomach being stranded by dampness, burnout is thermophilic Sleeping, born of the same parents' ruffian abdominal distension is lost the appetite, vomiting and having loose bowel, phlegm and retained fluid, and wet swollen, exterior syndrome folder is wet, head body weight pain, bi Zheng warm nature, and podomere is ached again It, impotence folds in a garment, yctalopia.

Fructus amomi：Acrid flavour, warm-natured, converge to the spleen channel, stomach；Dampness elimination appetizing, warming spleen and stopping diarrha, regulating the flow of vital energy antiabortive.For turbi damp obstructing in middle-JIAO, gastral cavity Ruffian is not hungry, deficiency-cold in spleen and stomach, vomiting and diarrhea, pernicious vomiting, fetal irritability etc..

Dried orange peel：Acrid flavour, hardship, warm-natured, returns spleen, stomach, lung channel；Qi-regulating is in, eliminating dampness and eliminating phlegm, sharp water defaecation.Not for taste With, abdominal distention, do not feel like eating, vomiting hiccup.

Rhizoma cyperi：Acrid flavour, slight bitter, micro-sweet, mild-natured, Return liver, spleen, tri-jiao channel；Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.With In stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is bored, turgor pain, irregular menstruation, warp Close dysmenorrhoea.

Dalbergia wood：Acrid flavour, warm-natured, Thoughts of returning home bag, Liver Channel；The hemostasis of the row stasis of blood, swelling and pain relieving.For metal-inflicted wound bleeding, traumatic injury, pain Bitterly, the diseases such as blood stasis and swelling pain.

Radix Paeoniae Alba：Bitter, acid, cold nature, Return liver, the spleen channel；Nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG.With In irregular menstruation, dysmenorrhea, the diseases such as uterine bleeding and spontaneous perspiration, night sweat.

Inula britannica chinensis：Bitter, pungent, salty, slightly warm in nature, return lung, stomach, large intestine channel；With sending down abnormally ascending, dissolving phlegm, row water, preventing or arresting vomiting effect. For cough due to wind-cold evil, phlegm and retained fluid stores knot, and chest diaphragm ruffian is bored, dyspnea and cough with excessive sputum, vomits gas, epigastric fullness and rigidity.

Sea salt：Taste is salty, cold in nature, returns stomach, kidney, large intestine, small intestinl channel；Logical product of spitting, cool blood of relieving inflammation or internal heat, priming return kidney.

Preferably, the sea salt grain size is 1-2mm.Not only there is a dehumidifying Na Shui after sea salt heating, the effect of anti-inflammatory analgetic, and And with local blood circulation is promoted, inflammation being promoted to absorb, external application is applicable in the theory of Chinese medicine " then obstructed, the no pain by smooth breath of pain ".And Grain size is the sea salt of 1-2mm, and thermotherapy effect is more excellent.

A method of preparing the above-mentioned pharmaceutical composition ruled by law based on hot salt and treat gastrointestinal dysfunction, including following preparation Step：

S1. radix bupleuri is weighed by weight, rhizoma zingiberis, wrinkled giant hyssop, eupatorium, Rhizoma Atractylodis Macrocephalae, cloves, the dried immature fruit of citron orange, Fructus Aurantii, Cortex Magnoliae Officinalis, fructus amomi is grey Art, dried orange peel, rhizoma cyperi, dalbergia wood, Radix Paeoniae Alba, Inula britannica chinensis, and crushed, it then crosses 100 mesh and sieves to obtain drug powder；

S2. drug powder obtained above and sea salt are uniformly mixed, is drying to obtain.

Further, it is disorderly based on hot salt ruling by law treatment gastrointestinal function comprising aforementioned pharmaceutical compositions that the present invention also provides a kind of Random salt packet.

Compared with prior art, beneficial effects of the present invention：

Radix bupleuri has soothing liver-gallbladder, dredges that gas solution is strongly fragrant, dissipates effect of fire；Rhizoma zingiberis warming spleen and stomach for dispelling cold, recover Yang and smooth venation, warming lung and resolving fluid； Wrinkled giant hyssop is eliminated dampness with aromatics and middle preventing or arresting vomiting, delivers relieving summer-heat；The antipyretic clear heat of eupatorium, dispelling damp-cold from the stomach and improving appetite and digestion, preventing or arresting vomiting；Rhizoma Atractylodis Macrocephalae strengthening the spleen and replenishing qi, eliminating dampness profit Water, hidroschesis；Cloves middle benefit gas drop is inverse；The dried immature fruit of citron orange cures mainly internal stagnation, feeling of fullness distending pain, constipation, weight after rush down dysentery；Fructus Aurantii qi-regulating is wide In, the stagnant dissipate-swelling of row；Cortex Magnoliae Officinalis has therapeutic effect to diseases such as stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiaos；Fructus amomi cures mainly taste gas Stagnant, place food does not disappear, abdominal pain swollen ruffian, and dysphagic vomiting is cold to rush down cold dysentery；Rhizoma atractylodis are drying damp and strengthening spleen, wind-damp dispelling；Dried orange peel regulating qi-flowing for strengthening spleen, eliminating dampness Resolving sputum；Rhizoma cyperi regulating the flow of vital energy Xie Yu, menstruction regulating and pain relieving；The hemostasis of the dalbergia wood row stasis of blood, swelling and pain relieving；Radix Paeoniae Alba nourishing blood for regulating menstruation, astringing YIN to stop sweating, soft liver are stopped Bitterly, suppressing liver-YANG；Inula britannica chinensis stomach invigorating eliminating the phlegm, also control in the heart big bored, distended stomach, heating, cough, vomit it is inverse etc..

The present invention provides the combination of above-mentioned traditional Chinese medicine ingredients, Chinese medicine each component scientific compatibility, interaction has aromatization The effect of wet, anti-vomiting, antidiarrheal of being amusing, regulating qi-flowing for relieving pain, and accelerate drug locally to import by hot salt, promote local blood to follow Ring improves the permeability of cell, absorbs local swelling exudate, to play promoting blood circulation and removing blood stasis, anti-inflammatory analgetic, promote cell repair The effect of, alleviate gastrointestinal dysfunction related symptoms significantly.

Specific implementation mode

In order to make the purpose , technical scheme and advantage of the present invention be clearer, below in conjunction with specific embodiment, to this Invention be further described, but the present invention claims protection domain be not limited to embodiment.

Sea salt grain size used by following embodiments is 1-2mm.

Embodiment 1:Prepare the salt packet ruled by law based on hot salt and treat gastrointestinal dysfunction

Formula：Radix bupleuri 5Kg, rhizoma zingiberis 5Kg, wrinkled giant hyssop 5Kg, eupatorium 5Kg, Rhizoma Atractylodis Macrocephalae 5Kg, cloves 5Kg, dried immature fruit of citron orange 5Kg, Fructus Aurantii 5Kg, Cortex Magnoliae Officinalis 5Kg, fructus amomi 5Kg, rhizoma atractylodis 5Kg, dried orange peel 5Kg, rhizoma cyperi 5Kg, dalbergia wood 5Kg, Radix Paeoniae Alba 5Kg, Inula britannica chinensis 5Kg.

Preparation method：S1. radix bupleuri is taken by above-mentioned weight, rhizoma zingiberis, wrinkled giant hyssop, eupatorium, Rhizoma Atractylodis Macrocephalae, cloves, the dried immature fruit of citron orange, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus amomi, rhizoma atractylodis, dried orange peel, rhizoma cyperi, dalbergia wood, Radix Paeoniae Alba, ten Six-element pulverizing medicinal materials of Inula britannica chinensis, and sieve with 100 mesh sieve to obtain drug powder；S2. By drug powder obtained above and sea salt by weight 7:3 uniformly mixing, it is dry in vacuum desiccator, it is prepared into powder； S3. powder is placed in pure cotton cloth bag, is packed.

Embodiment 2:Prepare the salt packet ruled by law based on hot salt and treat gastrointestinal dysfunction

Formula：Radix bupleuri 5Kg, rhizoma zingiberis 14Kg, wrinkled giant hyssop 12Kg, eupatorium 5Kg, Rhizoma Atractylodis Macrocephalae 5Kg, cloves 5Kg, dried immature fruit of citron orange 5Kg, Fructus Aurantii 8Kg, Cortex Magnoliae Officinalis 9Kg, fructus amomi 5Kg, rhizoma atractylodis 6Kg, dried orange peel 7Kg, rhizoma cyperi 5Kg, dalbergia wood 5Kg, Radix Paeoniae Alba 9Kg, Inula britannica chinensis 5Kg.

Preparation method：S1. radix bupleuri is taken by above-mentioned weight, rhizoma zingiberis, wrinkled giant hyssop, eupatorium, Rhizoma Atractylodis Macrocephalae, cloves, the dried immature fruit of citron orange, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus amomi, rhizoma atractylodis, dried orange peel, rhizoma cyperi, dalbergia wood, Radix Paeoniae Alba, ten Six-element pulverizing medicinal materials of Inula britannica chinensis, and sieve with 100 mesh sieve to obtain drug powder；S2. By drug powder obtained above and sea salt by weight 7:10 uniformly mixing, it is dry in vacuum desiccator, it is prepared into powder； S3. powder is placed in pure cotton cloth bag, is packed.

Embodiment 3:Prepare the salt packet ruled by law based on hot salt and treat gastrointestinal dysfunction

Formula：Radix bupleuri 5Kg, rhizoma zingiberis 5Kg, wrinkled giant hyssop 5Kg, eupatorium 5Kg, Rhizoma Atractylodis Macrocephalae 5Kg, cloves 5Kg, dried immature fruit of citron orange 5Kg, Fructus Aurantii 5Kg, Cortex Magnoliae Officinalis 5Kg, fructus amomi 5Kg, rhizoma atractylodis 5Kg, dried orange peel 5Kg, rhizoma cyperi 5Kg, dalbergia wood 5Kg, Radix Paeoniae Alba 5Kg, Inula britannica chinensis 5Kg.

Preparation method：S1. radix bupleuri is taken by above-mentioned weight, rhizoma zingiberis, wrinkled giant hyssop, eupatorium, Rhizoma Atractylodis Macrocephalae, cloves, the dried immature fruit of citron orange, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus amomi, rhizoma atractylodis, dried orange peel, rhizoma cyperi, dalbergia wood, Radix Paeoniae Alba, ten Six-element pulverizing medicinal materials of Inula britannica chinensis, and sieve with 100 mesh sieve to obtain drug powder；S2. By drug powder obtained above and sea salt by weight 1:1 uniformly mixing, it is dry in vacuum desiccator, it is prepared into powder； S3. powder is placed in pure cotton cloth bag, is packed.

Embodiment 4:Prepare the salt packet ruled by law based on hot salt and treat gastrointestinal dysfunction

Formula：Radix bupleuri 7Kg, rhizoma zingiberis 5Kg, wrinkled giant hyssop 7Kg, eupatorium 5Kg, Rhizoma Atractylodis Macrocephalae 5Kg, cloves 5Kg, dried immature fruit of citron orange 5Kg, Fructus Aurantii 7Kg, Cortex Magnoliae Officinalis 7Kg, fructus amomi 5Kg, rhizoma atractylodis 5Kg, dried orange peel 7Kg, rhizoma cyperi 7Kg, dalbergia wood 5Kg, Radix Paeoniae Alba 5Kg, Inula britannica chinensis 5Kg.

Preparation method：S1. radix bupleuri is taken by above-mentioned weight, rhizoma zingiberis, wrinkled giant hyssop, eupatorium, Rhizoma Atractylodis Macrocephalae, cloves, the dried immature fruit of citron orange, Fructus Aurantii, Cortex Magnoliae Officinalis, Fructus amomi, rhizoma atractylodis, dried orange peel, rhizoma cyperi, dalbergia wood, Radix Paeoniae Alba, ten Six-element pulverizing medicinal materials of Inula britannica chinensis, and sieve with 100 mesh sieve to obtain drug powder；S2. By drug powder obtained above and sea salt by weight 7:8 uniformly mixing, it is dry in vacuum desiccator, it is prepared into powder； S3. powder is placed in pure cotton cloth bag, is packed.

Comparative example 1:

Compared with Example 3, other conditions are identical, and only drug powder and sea salt are by weight 2:1.

Comparative example 2:

Compared with Example 3, other conditions are identical, and only drug powder and sea salt are by weight 1:3.

Comparative example 3:

Compared with Example 3, it is added without sea salt, other conditions are identical.

Comparative example 4:

Compared with Example 3, sea salt does not have traditional Chinese medicinal components in formula.

Comparative example 5：

Compared with Example 3, formula is identical, and preparation method is as follows：

S1. radix bupleuri is taken by above-mentioned weight, rhizoma zingiberis, wrinkled giant hyssop, eupatorium, Rhizoma Atractylodis Macrocephalae, cloves, the dried immature fruit of citron orange, Fructus Aurantii, Cortex Magnoliae Officinalis, fructus amomi is grey Art, dried orange peel, rhizoma cyperi, dalbergia wood, Radix Paeoniae Alba, ten Six-element pulverizing medicinal materials of Inula britannica chinensis, and cross 40 mesh and sieve to obtain drug powder；S2. it is obtained above-mentioned The drug powder and sea salt arrived is by weight 1:1 uniformly mixing, it is dry in vacuum desiccator, it is prepared into powder；S3. by powder It is placed in pure cotton cloth bag, packs.

Clinical test case

Clinical test is carried out to 1-4 of the embodiment of the present invention and comparative example 1-5 the salt packet prepared, it is specific as follows：

One, experiment sample

Select 360 patients, 360 patients be in July, 2015~2016 year July it is swollen with abdomen, be bitterly cardinal symptom Gastrointestinal dysfunction go to a doctor patient, clinical diagnosis meet Fang Qi chief editor《Modern clinical practice》Diagnostic criteria, and except woman produce Section and surgery abdomen disease.Wherein man 165, female 195, age are 12~65d of the course of disease between 18 years old~60 years old, average 32.6d. It is randomly divided into 9 groups each 40 according to medical sequence.

Age, gender, disease degree, the clinical manifestation etc. of above-mentioned five groups of patients is statistically analyzed, no significant difference Meaning (P>0.05) it, is comparable.

Two, experimental method

According to State Administration of Traditional Chinese Medicine's publication in 1994《Chinese medical disease Standardization of diagnosis and curative effect》, work out following curative effect and sentence Calibration is accurate：(1) effective：Symptom and sign disappear in 30min after medication.(2) effectively：Symptom and sign are bright in 30min after medication It is aobvious to mitigate.(3) invalid：Symptom and sign are not alleviated in 7d after medication.

Embodiment is as follows：(1) patient takes end sitting position or clinostatism, abdomen natural relaxation, fully exposes skin of abdomen, with controlling It treats towel and separates patient garments, pack when treatment is avoided to be infected with clothing；(2) it is applied with：Sizeable salt is selected according to operating position Packet, is heated to 60 DEG C, spreads on abdomen, and the topical application of drug time is about 30 minutes, 2 times/day, 7 days as one therapeutic course.Five groups of patients are by same Doctor observes and records symptom and sign variation daily.

Clinical efficacy is as shown in table 1 after treatment, and the therapeutic effect of 1-4 of the embodiment of the present invention is substantially better than comparative example 1-5. Comparative example 3,4 is respectively that traditional Chinese medicine ingredients are used alone and sea salt is used alone as pharmaceutical formulation, and therapeutic effect is substantially less than The existing traditional Chinese medicine ingredients of embodiment 1-4 have the using effect of sea salt again；And in comparative example 1,2, the quality of traditional Chinese medicine ingredients and sea salt Than not in the ratio range of the present invention, therapeutic effect is also significantly lower than the therapeutic effect of embodiment 1-4.On the one hand, in medicine The content of sea salt is excessive in compositions, then traditional Chinese medicinal components content is very few, cannot effectively volatilize functional component；On the other hand, The content of sea salt is very few in pharmaceutical composition, and heating effect and fever time reduce, and the same traditional Chinese medicinal components that influence play work( Effect.Comparative example 5 changes the preparation method of traditional Chinese medicinal components, and traditional Chinese medicinal components grain size is too big, and traditional Chinese medicinal components can not be volatilized effectively Functional component, therapeutic effect are also significantly lower than the therapeutic effect of embodiment 1-4.Stomach and intestine are treated it is found that being ruled by law the present invention is based on hot salt In the pharmaceutical composition of dysfunction, traditional Chinese medicinal components and sea salt scientific compatibility, have remove dampness by means of aromatics, anti-vomiting, antidiarrheal of being amusing, The effect of regulating qi-flowing for relieving pain, to alleviate disease symptoms significantly.

Curative effect compares (n (%)) after table 1 is treated

Group	It is effective	Effectively	In vain	Total effective rate
					Embodiment 1	24(65)	12(30)	4(10)	90%*
Embodiment 2	25(65)	11(30)	4(10)	90%*
					Embodiment 3	26(65)	12(30)	2(5)	95%*
Embodiment 4	24(65)	13(30)	3(7.5)	92.5%*
					Comparative example 1	13(32.5)	14(35)	13(32.5)	67.5%*
Comparative example 2	14(35)	14(35)	12(30)	70%*
					Comparative example 3	12(30)	12(30)	16(40)	60%*
Comparative example 4	12(30)	10(25)	18(45)	55%*
					Comparative example 5	13(32.5)	13(32.5)	14(35)	65%*

According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-mentioned embodiment party Formula is changed and is changed.Therefore, the invention is not limited in specific implementation modes disclosed and described above, to the one of invention A little modifications and changes should also be as falling into the scope of the claims of the present invention.In addition, although being used in this specification Some specific terms, these terms are merely for convenience of description, does not limit the present invention in any way.

Claims (5)

1. a kind of ruling the pharmaceutical composition for treating gastrointestinal dysfunction by law based on hot salt, which is characterized in that described pharmaceutical composition packet Containing sea salt and traditional Chinese medicinal components, wherein the traditional Chinese medicinal components include the ingredient of following parts by weight：

5-15 parts of radix bupleuri, 5-15 parts of rhizoma zingiberis, 5-15 parts of wrinkled giant hyssop, 5-15 parts of eupatorium, 5-15 parts of Rhizoma Atractylodis Macrocephalae, 5-15 parts of cloves, dried immature fruit of citron orange 5- 15 parts, 5-15 parts of Fructus Aurantii, 5-15 parts of Cortex Magnoliae Officinalis, 5-15 parts of fructus amomi, 5-15 parts of rhizoma atractylodis, 5-15 parts of dried orange peel, 5-15 parts of rhizoma cyperi, dalbergia wood 5- 15 parts, 5-15 parts of Radix Paeoniae Alba, 5-15 parts of Inula britannica chinensis；

The weight ratio of the sea salt and traditional Chinese medicinal components is 3-10:7.

2. ruling the pharmaceutical composition for treating gastrointestinal dysfunction by law based on hot salt according to claim 1, which is characterized in that described Traditional Chinese medicinal components include the ingredient of following parts by weight：

5-7 parts of radix bupleuri, 5-7 parts of rhizoma zingiberis, 5-7 parts of wrinkled giant hyssop, 5-7 parts of eupatorium, 5-7 parts of Rhizoma Atractylodis Macrocephalae, 5-7 parts of cloves, 5-7 parts of the dried immature fruit of citron orange, trifoliate orange 5-7 parts of shell, 5-7 parts of Cortex Magnoliae Officinalis, 5-7 parts of fructus amomi, 5-7 parts of rhizoma atractylodis, 5-7 parts of dried orange peel, 5-7 parts of rhizoma cyperi, 5-7 parts of dalbergia wood, Radix Paeoniae Alba 5-7 Part, 5-7 parts of Inula britannica chinensis；

The weight ratio of the sea salt and traditional Chinese medicinal components is 1:1.

3. according to claim 1 or claim 2 rule the pharmaceutical composition for treating gastrointestinal dysfunction by law based on hot salt, which is characterized in that The sea salt grain size is 1-2mm.

4. a kind of prepare rules the pharmaceutical composition for treating gastrointestinal dysfunction by law based on hot salt described in any one of claim 1-3 Method, which is characterized in that include the following steps：

S1. radix bupleuri is weighed by weight, rhizoma zingiberis, wrinkled giant hyssop, eupatorium, Rhizoma Atractylodis Macrocephalae, cloves, the dried immature fruit of citron orange, Fructus Aurantii, Cortex Magnoliae Officinalis, fructus amomi, rhizoma atractylodis are old Skin, rhizoma cyperi, dalbergia wood, Radix Paeoniae Alba, Inula britannica chinensis, and crushed, then sieve with 100 mesh sieve to obtain drug powder；

S2. drug powder obtained above and sea salt are uniformly mixed, is drying to obtain.

5. a kind of ruling the salt packet for treating gastrointestinal dysfunction by law based on hot salt, which is characterized in that the salt packet includes claim 1-3 Any one of described in pharmaceutical composition.