CN105727215A - Traditional Chinese medicinal prescription for treating severe acute pancreatitis and preparation method of traditional Chinese medicinal prescription - Google Patents

Traditional Chinese medicinal prescription for treating severe acute pancreatitis and preparation method of traditional Chinese medicinal prescription Download PDF

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Publication number
CN105727215A
CN105727215A CN201410747504.XA CN201410747504A CN105727215A CN 105727215 A CN105727215 A CN 105727215A CN 201410747504 A CN201410747504 A CN 201410747504A CN 105727215 A CN105727215 A CN 105727215A
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radix
traditional chinese
chinese medicinal
chinese medicine
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卢彦敏
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Qingdao Huangdao Hospital of Traditional Chinese Medicine
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Qingdao Huangdao Hospital of Traditional Chinese Medicine
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Abstract

The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicinal prescription for treating severe acute pancreatitis and a preparation method of the traditional Chinese medicinal prescription. The traditional Chinese medicinal prescription is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 2-5 parts of aloe, 3-5 parts of rhizoma alismatis, 3-5 parts of bamboo shavings, 5-10 parts of rhizoma pinelliae, 3-5 parts of cattail pollen, 1-2 parts of herb of common corydalis, 4-6 parts of radix salviae miltiorrhizae, 4-6 parts of radix scutellariae, 3-5 parts of fructus gardeniae, 5-10 parts of radix bupleuri, 4-6 parts of paeoniae radix alba, 4-6 parts of fresh ginger, 5-10 parts of fructus aurantii immaturus, 5-10 parts of fructus jujubae, 5-10 parts of radix et rhizoma rhei, 5-10 parts of mirabilite and 3-5 parts of radix kansui. The preparation method comprises a step of decocting the raw materials, so that a decoction is obtained. Since the traditional Chinese medicines have functions of regulating qi circulation and relieving depression, promoting blood circulation and removing stasis, tonifying qi and rescuing yin, the traditional Chinese medicinal prescription disclosed by the invention can reduce pancreatic gland secretion, rapidly regulate inflammatory autoreaction, prevent endotoxin translocation, relieve pain in patients and save patients' lives.

Description

A kind of Chinese medicine formula treating acute critical pancreatitis and preparation method thereof
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly to a kind of Chinese medicine formula treating acute critical pancreatitis and preparation method thereof.
Background technology
Acute pancreatitis is that Different types of etiopathogenises causes that pancreatin causes pancreatic tissue autodigestion, edema, hemorrhage even downright bad inflammatory reaction after being activated in pancreas.Clinical increase etc. as feature with acute upper abdominal pain, Nausea and vomiting, heating and blood pancreatin.Not etc., the lighter is not based on pancreas edema, clinical common for lesion degree weight, the state of an illness often in self limiting, prognosis bona, be also called mild acute pancreatitis.The pancreatic hemorrhage of minority severe one is downright bad, normal secondary infection, peritonitis and shock etc., and case fatality rate is high, is called acute critical pancreatitis.
The acute critical pancreatitis of 70%~80% is caused by biliary tract, excessive drinking and eating and drinking too much at one meal, pathogenesis is mainly the pancreatic juice result to pancreas and surrounding tissue autodigestion thereof, inflammatory cytokine is interrelated and cumulative function, causes the generation of the crisis such as vascular leakage, Hypovolemia, multiple system organ failure.The most basic most important link for the treatment of acute pancreatitis is to reduce pancreatic secretion, Chinese patent (CN103191322A) discloses a kind of Chinese medicine treating acute critical pancreatitis, by improve serious symptom urgency patient gastrointestinal function, suppress Digestive system secretion, suppress tryptic activity, thus alleviating pancreatic tissue inflammation, reducing the order of severity of the state of an illness, but acute critical pancreatitis rapid onset, development are rapidly, need fast onset, contain PD rapidly, it is possible to the medicine of recuperating depleted YANG and rescuing the patient from collapse is treated.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine formula treating acute critical pancreatitis, by the regulating the flow of QI to alleviate depression of Chinese medicine, blood circulation promoting and blood stasis dispelling, benefiting QI and recuperating YIN-fluid effect, it is possible to reduce pancreatic juice glandular secretion, quickly regulate auto-inflammatory reaction, prevention Endotoxin Translocation, alleviates patient's misery, saves patients ' lives.
The present invention provides a kind of Chinese medicine formula treating acute critical pancreatitis, formulated by the raw material of Chinese medicine of following parts by weight: Aloe 2~5 parts, Rhizoma Alismatis 3~5 parts, Caulis Bambusae In Taenia 3~5 parts, the Rhizoma Pinelliae 5~10 parts, Pollen Typhae 3~5 parts, Herba corydalis edulis 1~2 part, Radix Salviae Miltiorrhizae 4~6 parts, Radix Scutellariae 4~6 parts, Fructus Gardeniae 3~5 parts, Radix Bupleuri 5~10 parts, Radix Paeoniae 4~6 parts, 4~6 parts of Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 5~10 parts, 5~10 parts of Fructus Jujubae, Radix Et Rhizoma Rhei 5~10 parts, 5~10 parts of Natrii Sulfas, Radix Kansui 3~5 parts.
It is preferred that be that the raw material of Chinese medicine by following parts by weight is formulated: Aloe 3 parts, Rhizoma Alismatis 4 parts, Caulis Bambusae In Taenia 4 parts, the Rhizoma Pinelliae 6 parts, Pollen Typhae 4 parts, Herba corydalis edulis 1 part, Radix Salviae Miltiorrhizae 5 parts, Radix Scutellariae 5 parts, Fructus Gardeniae 4 parts, Radix Bupleuri 7 parts, Radix Paeoniae 5 parts, 5 parts of Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 8 parts, 6 parts of Fructus Jujubae, Radix Et Rhizoma Rhei 7 parts, 8 parts of Natrii Sulfas, Radix Kansui 4 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 2~5cm, and soaked 1~2 hour;Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20~40min to;After cooked, leach medicine juice and decoct as head;Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Pharmacology analysis:
Aloe: bitter in the mouth is cold in nature, under rushing down;There is anti-gastric-ulcer, anti-liver injury, removing heat from the liver removing the relative excess fire action.
Rhizoma Alismatis: sweet, cold;Enter kidney, bladder warp.Effect diuretic, eliminating dampness by diuresis, expel the heat-evil;Cure mainly dysuria, edema distension, vomiting, dysentery, phlegm retention, beriberi, gonorrhea, hematuria.
Caulis Bambusae In Taenia: cold nature, sweet in the mouth;Function removing heat-phlegm, relieves restlessness and prevents vomiting;Expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement is held under the arm for phlegm-heat cough, gallbladder fire.
The Rhizoma Pinelliae: feeble QI, taste is micro-puckery;Function drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus;Raw with external treatment carbuncle sucutaneous nodule.
Pollen Typhae: sweet in the mouth, micro-pungent, property is put down, and returns liver, the heart, spleen channel.Function is stopped blooding, and blood stasis dispelling is treating stranguria.For spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea, dysmenorrhea, gastral cavity ventral spine pain, treating swelling and pain by traumatic injury, the wet pain of stranguria with blood etc..
Herba corydalis edulis: bitter, puckery is cool;Poisonous.Cure mainly pulmonary tuberculosis hemoptysis, seminal emission, sore, stubborn dermatitis.
Radix Salviae Miltiorrhizae: nature and flavor are bitter, are slightly cold;GUIXIN, Liver Channel.There are stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, chest and abdomen twinge, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia;Hepatosplenomegaly, angina pectoris.
Radix Scutellariae: bitter in the mouth, cold in nature, enters the heart, lung, gallbladder, large intestine channel;There are heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive;Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.Modern pharmacology proves, Radix Scutellariae has the effects such as antibacterial action, antifungic action, antivirus action and antiinflammatory antiallergic action, and does not develop immunity to drugs.
Fructus Gardeniae: heat clearing away, pathogenic fire purging, removing heat from blood;Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, haematemesis, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprain and swell and ache, there is the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.
Radix Bupleuri: nature and flavor are bitter, are slightly cold.Return liver, gallbladder meridian.There is reconciling superficies and interior, soothing the liver, effect of yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.
Radix Paeoniae: Radix Paeoniae contains the multi-medicament composition such as peoniflorin and paeoniflorin, has the effect of expansion blood vessel, blood pressure lowering analgesia, heat clearing away spasmolytic, has higher medical value.
Rhizoma Zingiberis Recens: acrid in the mouth, hot in nature;Return spleen, stomach, the heart, lung meridian.Effect warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention;Cure mainly coldness and pain in the epigastrium, vomit, have loose bowels, YANG-depletion faint inverse, cold fluid-retention is breathed with cough, arthralgia due to cold-dampnes.
Fructus Jujubae: sweet in the mouth, pungent, warm in nature, nontoxic;Return spleen, stomach warp;Cure mainly trusted subordinate's pathogen, few body fluid, physical weakness, frightened, heaviness of limbs;Function regulating the spleen and stomach, supports the flat gastric qi of temper, invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind;Logical nine orifices, helps Bu Erjing, mends few gas and hundred medicines.Taking for a long time to make light of one's life by commiting suicide prolongs life.
Radix Et Rhizoma Rhei: bitter in the mouth, cold;Return spleen, stomach, large intestine, liver, pericardium channel.Effect is attacked stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances;Cure mainly excess-heat constipation, the accumulation of heat feeling of stuffiness in chest, damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria, conjunctival congestion, laryngopharynx swelling and pain, aphtha of the mouth and tongue, gastropyretic vomiting, spit blood, spitting of blood, epistaxis, have blood in stool, hematuria, blood-retention, amenorrhea, puerperal the stagnant stomachache of the stasis of blood, lump in the abdomen, traumatic injury, pyretic toxicity carbuncle and ulcer, erysipelas, scald.
Natrii Sulfas: salty, bitter, cold;Return stomach warp, lung meridian, spleen channel, kidney channel, small intestine meridian, tri-jiao channel, large intestine channel.Function purging heat to relax the bowels, moistening for dryness and softening hard mass, detumescence of relieving inflammation or internal heat, cure mainly brokenly painful abdominal mass, in room temperature, help digestion, relieve oedema or abdominal distension through diuresis or purgation, cathartic.For gastral cavilty painful abdominal mass, eat painful abdominal mass, dyspepsia, edema, edema, swelling of the breast, amenorrhea, constipation.
Fructus Aurantii Immaturus: bitter, pungent, cold;Return spleen, stomach, liver, heart channel.Stop in effect is stagnant, feeling of fullness distending pain, constipation, weight, blocked-up chest, gastroptosis, uterine prolapse, proctoptosis after dysentery.
Cortex Magnoliae Officinalis: bitter, pungent, warm in nature;Return spleen channel, stomach warp, large intestine channel.Function circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma;Curing mainly stagnation of QI due to dyspepsia, abdominal distention constipation, retention of dampness in middle-JIAO, gastral cavity painful abdominal mass is vomited and diarrhoea, and expectorant stops up QI rising in reverse order, and fullness in the chest is breathed with cough.
Radix Kansui: bitter in the mouth;Cold in nature, poisonous;Return spleen channel, lung meridian, kidney channel, bladder warp, large intestine channel, small intestine meridian.Function removing water retention by purgation by swollen, dispersing swelling and dissipating binds;Cure mainly edema, ascites, prolonged fluid-retention blocked-up chest, epilepsy, breath with cough, sphincter disturbance.
The Chinese medicine of the present invention, by the regulating the flow of QI to alleviate depression of Chinese medicine, blood circulation promoting and blood stasis dispelling, benefiting QI and recuperating YIN-fluid effect, it is possible to reduce pancreatic juice glandular secretion, quickly regulate auto-inflammatory reaction, prevent Endotoxin Translocation, alleviate patient's misery, save patients ' lives.
Outcome measure:
Effective: in 3 days, symptom, sign are alleviated, and in 7 days, blood, amylase in urine recover normal substantially.
Effective: in 7 days, symptom, sign alleviate, blood, amylase in urine have downward trend;
Invalid: in 7 days, symptom does not alleviate or worsens;
Therapeutic outcome: treat 103 patients with severe acute pancreatitis, 1st is 1 course for the treatment of, 1 day 2 doses.After taking medicine of the present invention, effective 39 examples, account for 37.9%, effective 61 examples, account for 59.2%, invalid 3 examples, account for 2.9%.
Attached a few example case is described further:
Case 1: bavin, male, 36 years old, because burst upper abdominal pain is admitted to hospital for 10 hours, after a large amount of meat of being satiated with food before 10 hours, epigastrium pain occurs suddenly, in persistence angor, companion perspires, feels sick, and the pain increased afterwards, accompanies malaise, profuse perspiration, without aerofluxus and stool, pancreas CT shows vascular leakage, is shown as acute critical pancreatitis, then gives treatment by Chinese herbs of the present invention, effective after 3 days, inflammatory reaction is blocked, and after 5 days, blood, amylase in urine recover normal substantially.
Case 2: restrain certain, women, 55 years old, because stomachache, vomiting are admitted to hospital, increase with blood, amylase in urine and hemogram, peritonitis stimulation is levied, all cases all has pancreas enlargement, a necrosis through CT examination, companion abdominal cavity or pancreas week hydrops or bloody ascites, disconnected disease is acute critical pancreatitis, then treatment by Chinese herbs of the present invention is given, after 3 days effective, inflammatory reaction is blocked, and after 7 days, blood, amylase in urine recover normal substantially.
Detailed description of the invention
Embodiment 1:
A kind of Chinese medicine formula treating acute critical pancreatitis, formulated by the raw material of Chinese medicine of following parts by weight: Aloe 3 parts, Rhizoma Alismatis 4 parts, Caulis Bambusae In Taenia 4 parts, the Rhizoma Pinelliae 6 parts, Pollen Typhae 4 parts, Herba corydalis edulis 1 part, Radix Salviae Miltiorrhizae 5 parts, Radix Scutellariae 5 parts, Fructus Gardeniae 4 parts, Radix Bupleuri 7 parts, Radix Paeoniae 5 parts, 5 parts of Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 8 parts, 6 parts of Fructus Jujubae, Radix Et Rhizoma Rhei 7 parts, 8 parts of Natrii Sulfas, Radix Kansui 4 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 4cm, and soaked 1.5 hours;Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 30min to;After cooked, leach medicine juice and decoct as head;Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Embodiment 2:
A kind of Chinese medicine formula treating acute critical pancreatitis, formulated by the raw material of Chinese medicine of following parts by weight: Aloe 2 parts, Rhizoma Alismatis 5 parts, Caulis Bambusae In Taenia 3 parts, the Rhizoma Pinelliae 10 parts, Pollen Typhae 3 parts, Herba corydalis edulis 2 parts, Radix Salviae Miltiorrhizae 4 parts, Radix Scutellariae 6 parts, Fructus Gardeniae 3 parts, Radix Bupleuri 10 parts, Radix Paeoniae 4 parts, 6 parts of Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 5 parts, 10 parts of Fructus Jujubae, Radix Et Rhizoma Rhei 5 parts, 10 parts of Natrii Sulfas, Radix Kansui 3 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 2cm, and soaked 2 hours;Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20min to;After cooked, leach medicine juice and decoct as head;Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Embodiment 3:
A kind of Chinese medicine formula treating acute critical pancreatitis, formulated by the raw material of Chinese medicine of following parts by weight: Aloe 5 parts, Rhizoma Alismatis 3 parts, Caulis Bambusae In Taenia 5 parts, the Rhizoma Pinelliae 5 parts, Pollen Typhae 5 parts, Herba corydalis edulis 1 part, Radix Salviae Miltiorrhizae 6 parts, Radix Scutellariae 4 parts, Fructus Gardeniae 5 parts, Radix Bupleuri 5 parts, Radix Paeoniae 6 parts, 4 parts of Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 10 parts, 5 parts of Fructus Jujubae, Radix Et Rhizoma Rhei 10 parts, 5 parts of Natrii Sulfas, Radix Kansui 5 parts.
Preparation method following steps form: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 5cm, and soaked 1 hour;Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 40min to;After cooked, leach medicine juice and decoct as head;Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
Below the present invention is described in detail, the above, it is only the preferred embodiments of the invention, when the scope of the present invention can not be limited, namely all done impartial change according to the application scope and modify, all should still belong in covering scope of the present invention.

Claims (3)

1. the Chinese medicine formula treating acute critical pancreatitis, it is characterised in that formulated by the raw material of Chinese medicine of following parts by weight: Aloe 2~5 parts, Rhizoma Alismatis 3~5 parts, Caulis Bambusae In Taenia 3~5 parts, the Rhizoma Pinelliae 5~10 parts, Pollen Typhae 3~5 parts, Herba corydalis edulis 1~2 part, Radix Salviae Miltiorrhizae 4~6 parts, Radix Scutellariae 4~6 parts, Fructus Gardeniae 3~5 parts, Radix Bupleuri 5~10 parts, Radix Paeoniae 4~6 parts, 4~6 parts of Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 5~10 parts, 5~10 parts of Fructus Jujubae, Radix Et Rhizoma Rhei 5~10 parts, 5~10 parts of Natrii Sulfas, Radix Kansui 3~5 parts.
2. a kind of Chinese medicine formula treating acute critical pancreatitis as claimed in claim 1, it is characterised in that formulated by the raw material of Chinese medicine of following parts by weight: Aloe 3 parts, Rhizoma Alismatis 4 parts, Caulis Bambusae In Taenia 4 parts, the Rhizoma Pinelliae 6 parts, Pollen Typhae 4 parts, Herba corydalis edulis 1 part, Radix Salviae Miltiorrhizae 5 parts, Radix Scutellariae 5 parts, Fructus Gardeniae 4 parts, Radix Bupleuri 7 parts, Radix Paeoniae 5 parts, 5 parts of Rhizoma Zingiberis Recens, Fructus Aurantii Immaturus 8 parts, 6 parts of Fructus Jujubae, Radix Et Rhizoma Rhei 7 parts, 8 parts of Natrii Sulfas, Radix Kansui 4 parts.
3. the method for the preparation Chinese medicine formula treating acute critical pancreatitis as claimed in claim 1, it is characterised in that be made up of following steps: weigh raw material of Chinese medicine by above-mentioned weight portion, add cold water, do not have medical material 2~5cm, and soaked 1~2 hour;Then decoct, first boil with high heat, after boiling, transfer slow fire infusion 20~40min to;After cooked, leach medicine juice and decoct as head;Medicinal residues repeat the above steps is decocted, after cooked, the medicine juice of twice decoction is merged.
CN201410747504.XA 2014-12-09 2014-12-09 Traditional Chinese medicinal prescription for treating severe acute pancreatitis and preparation method of traditional Chinese medicinal prescription Pending CN105727215A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107088209A (en) * 2017-06-22 2017-08-25 贵州省安顺市黔艺贝纺织有限公司 A kind of seedling medicine for treating pancreatitis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107088209A (en) * 2017-06-22 2017-08-25 贵州省安顺市黔艺贝纺织有限公司 A kind of seedling medicine for treating pancreatitis

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