CN108542978A - The preparation method of the anti-inflammatory particle health products of clearing - Google Patents
The preparation method of the anti-inflammatory particle health products of clearing Download PDFInfo
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- CN108542978A CN108542978A CN201810539098.6A CN201810539098A CN108542978A CN 108542978 A CN108542978 A CN 108542978A CN 201810539098 A CN201810539098 A CN 201810539098A CN 108542978 A CN108542978 A CN 108542978A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A—HUMAN NECESSITIES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention provides a kind of preparation methods of the anti-inflammatory particle health products of clearing, including extraction, filtering, concentration, allotment, granulation, drying steps, wherein, the ampelopsis grossdentata place of production is Jiangxi Province Lichuan County, filter is plate filter, and filter cloth is 150 mesh, and each parts by weight in formula are：49 parts of ampelopsis grossdentata, 38 parts of honeysuckle, 25 parts of chrysanthemum, 13 parts of peppermint, 13 parts of Siraitia grosvenorii, 12 parts of the sterculia seed, 1 1.5 parts of honey-fried licorice root, 0.5 1 parts of honey.Above-mentioned seven kinds of raw materials synergistic effect in the anti-inflammatory particle health products of clearing prepared by the present invention, pharyngeal discomfort symptom can be effectively relieved, the benefits of with clearing throat, in this formula, ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root are all in " being both food and the article list of drug ", safety, which has, to be ensured, meanwhile, raw material is easy to get.
Description
Technical field
The present invention relates to and health product technology field, and in particular, to a kind of preparation side of the anti-inflammatory particle health products of clearing
Method.
Background technology
Pharynx is that air, diet enter the thoroughfare of human body, being the external world has positioned at the starting crossing of respiratory system and digestive system
One of the position that noxa element is most easily encroached on.With social progress and development, the substance of people and cultural life are gradually enriched, by
This also brings a series of new era illness.People are due to long-term operating pressure, frequent social, dinner party, dietary structure
It is unreasonable, and smoking and passive smoking, the in addition pollution of environment, easily cause congested, scorching hot, red and swollen, the pain of throat
Bitterly, dry and foreign body sensation, or even there are the symptoms such as cough, hoarseness, these symptoms can use again because of flu, fatigue, vocal cords
Excessively and the infection of the upper respiratory tract and aggravate, therefore can cause people lose the appetite and it is apathetic, severe patient influences whether it
Working efficiency and quality of life.
According to World Health Organization's investigation statistics, adult " chronic pharyngitis " illness rate has reached 80% or more, particularly with
For the crowd of some special industries, the ratio of pharyngeal illness increases year by year.Show that teachers in primary and middle schools exhale according to sample survey results
Desorption system Prevalence Rate of Chronic Diseases is higher, and wherein andropathy illness rate is 68.53%, and women illness rate is 71.06%, and is had
Increase and raised trend with the length of teaching.According to another investigation display, the leader to occupy an important position in enterprise or organ and backbone are suffered from
For the number of pharyngeal illness considerably beyond other illnesss number is suffered from, undesirable custom, unreasonable dietary structure and environment are dirty
Dye etc., will certainly injure the organs such as lung, liver, kidney, can be after it has been proved by practice that indigestion, tuberculosis, hepatopathy, nephrosis etc.
Send out pharyngolaryngitis.
Invention content
For overcome the deficiencies in the prior art, this application provides a kind of preparation methods of the anti-inflammatory particle health products of clearing.
The present invention provides a kind of preparation methods of the anti-inflammatory particle health products of clearing, including following preparation process：
Step A：Extraction
Ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root are weighed to the weight in formula respectively
Part is measured, mixing is put into gauze bag；Gauze bag equipped with medicinal material is placed in the extractor equipped with ultrasonic wave, is added 10-12 times
Extracting solution a is discharged ultrasonic extraction 1.5-2.0 hours at a temperature of 60 DEG C in 75% ethyl alcohol of medicinal material amount；Again toward equipped with ultrasonic wave
75% ethyl alcohol of 6-8 times of medicinal material amount is added in extractor ultrasonic extraction 1.0-1.5 hours at a temperature of 60 DEG C, extracting solution b is discharged；
Step B：Filtering, concentration
Merge extracting solution a and extracting solution b, filtered with filter, filter vacuum concentration, obtain relative density 1.3-1.5 it
Between concentrated extract；
Step C：Allotment
Honey is weighed by formula to be added in the concentrated extract obtained by step B, is stirred, then be charged with paste
Essence stirs, and obtains mixed powder；
Step D：Granulation, drying
Binder is added into mixed powder to be uniformly mixed, then uniform particle is made by 22 mesh screens with fashion of extrusion；
Particle is placed in spray-drying process device it is dry, then with Fastgranulatemachine whole grain,
The ampelopsis grossdentata place of production is Jiangxi Province Lichuan County, and the filter is plate filter, filter cloth 150
Mesh, the ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root, honey parts by weight be：
Preferably, the binder is 30% Macrogol 4000.
Preferably, the parts by weight of the ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root
For：
Chinese medicine, which itches pharyngeal portion flare pain, dysphagia, foreign matters from being blocked sense, pharynx, does the throat disease for cardinal symptom such as bright,
Referred to as " larynx numbness ", it is corresponding with the pharyngitis of doctor trained in Western medicine.Chinese medicine thinks, pharyngitis it is outer because experiencing wind-heat cult poison, it is interior because lung stomach has
Heat, YIN-fluid being insufficient, water fire not processed, flaring up of deficient fire smoke bright throat, and inside and outside cult poison knot causes this disease.
Ampelopsis grossdentata, which has, in the raw materials used in the present invention promotes the production of body fluid to quench thirst, sweet throat and moistening lung, eliminating inflammation and expelling toxin, the drop fire of deficiency type, helps and disappear
Change, be depressured weight-reducing, moistening skin beautifying and other effects, be especially suitable for fat and smoking personage and drink after drinking.Honeysuckle has heat-clearing solution
The effect of poison, wind-heat dissipating, antibacterial action is wider, has stronger suppression to the bacillus, coccus and salmonella of various pathogens
It makes and uses.
Chrysanthemum is a kind of conventional Chinese medicine, has effects that dispelling wind, heat-clearing, improving eyesight, removing toxic substances, at the same also with antibacterial, it is anti-inflammatory,
The multiple pharmacological effects such as anti-oxidant, adhere to taking for a long time has good therapeutic effect to chronic pharyngitis.
The anti-irritant effect of menthol causes tracheae to generate new secretion, makes the mucus of stiff be easy to be discharged, therefore has eliminating the phlegm
Effect, shows that menthol has stronger antibacterial action to staphylococcus epidermis, staphylococcus aureus etc. through in vitro test.
For Siraitia grosvenorii as folk medicinal plants, medicinal part is its fruit, have moisten the lung and relieve the cough, the drug effects such as eliminating the phlegm.It is fat big
Sea has effects that heat-clearing, moistening lung, relieving sore-throat, removing toxic substances, can treat the diseases such as dry cough without phlegm, laryngalgia hoarse voice, hot eyes toothache, clinically often
For lung heat celostomia, throat is hoarse suddenly and excessively neighs with the caused sound that shouts at the top of one's voice with cough, thirsty pharyngalgia, with throat
It is mute.
Honey-fried licorice root has relieving cough and reducing sputum effect, is used for tracheitis, coughing with a lot of sputum caused by the disease of pulmonary emphysema, and asthma sticks phlegm not
The easily diseases such as discharge, simultaneously, it may also be used for ulcer sores, abscess of throat, wet poison have antibacterial and anti-inflammation functions.
Above-mentioned seven kinds of raw materials synergistic effect in the anti-inflammatory particle health products of clearing prepared by the present invention, can be effectively relieved it is pharyngeal not
Suitable symptom, has the benefits of clearing throat.In this formula, ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, toast
Radix Glycyrrhizae is all in " being both food and the article list of drug ", and safety has guarantee, meanwhile, raw material is easy to get.
Description of the drawings
Fig. 1 is the anti-inflammatory particle health products preparation method flow chart of clearing of the present invention.
Specific implementation mode
The present invention is described further by following embodiment, but the present invention is not intended to be limited thereto.
Embodiment 1
A kind of anti-inflammatory particle health products of clearing, including the extract of following raw material calculated in parts by weight, the place of production is river
4 parts aobvious of tooth porcelain ampelopsis of the Lichuan Counties Xi Sheng, 8 parts of honeysuckle, 3 parts of chrysanthemum, 1 part of peppermint, 3 parts of Siraitia grosvenorii, 1 part of the sterculia seed, toast are sweet
1 part of grass；Further include 0.5 part of honey.
Referring to Fig.1, the preparation method of the anti-inflammatory particle health products of the clearing, includes the following steps：
Step A：Extraction
Ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed and honey-fried licorice root are weighed according to above-mentioned formula, is mixed
Conjunction is put into gauze bag；Gauze bag equipped with medicinal material is placed in the extractor equipped with ultrasonic wave, 10 times of medicinal material amounts of addition
75% ethyl alcohol ultrasonic extraction 1.5 hours at a temperature of 60 DEG C, discharge extracting solution a；Again into the extractor equipped with ultrasonic wave, it is added
75% ethyl alcohol of 8 times of medicinal material amounts ultrasonic extraction 1.5 hours at a temperature of 60 DEG C, discharge extracting solution b.
Step B：Filtering, concentration
Merge extracting solution a and b, filtered with plate filter, filter cloth is 150 mesh, and filter vacuum is concentrated to give concentrated extract, is surveyed
The relative density for obtaining concentrated extract is 1.35.
Step C：Allotment
Honey is weighed by formula to be added in the concentrated extract in step B, is stirred, then be charged with suitable
Dextrin stirs, and obtains mixed powder.
Step D：Granulation, drying
Mixed powder be added 30% Macrogol 4000 be made " hand pinch it is agglomerating, pressure it is i.e. scattered " softwood, then with fashion of extrusion
By 22 mesh screens (plate), uniform particle is made.Wet granular is placed in spray-drying process device it is dry, then with quick whole grain
Machine whole grain is obtained with the anti-inflammatory particle of clearing.
Embodiment 2
A kind of anti-inflammatory particle health products of clearing, including the extract of following raw material calculated in parts by weight, the place of production is river
9 parts aobvious of ampelopsis grossdentata of the Lichuan Counties Xi Sheng, 3 parts of honeysuckle, 2 parts of chrysanthemum, 2 parts of peppermint, 1 part of Siraitia grosvenorii, 3 parts of the sterculia seed, toast
1.5 parts of Radix Glycyrrhizae further includes 1.0 parts of honey.
Referring to Fig.1, the preparation method of the anti-inflammatory particle of above-mentioned clearing, includes the following steps：
Step A：Extraction
Above-mentioned ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root are weighed accordingly respectively
It is put into togerther in gauze bag after amount, the gauze bag equipped with medicinal material is placed in the extractor equipped with ultrasonic wave, 11 times of medicinal materials are added
Extracting solution a is discharged in 75% ethyl alcohol of amount ultrasonic extraction 1.5 hours at a temperature of 60 DEG C, then into the extractor equipped with ultrasonic wave,
75% ethyl alcohol of 6 times of medicinal material amounts of addition ultrasonic extraction 1.0 hours at a temperature of 60 DEG C, discharge extracting solution b.
Step B：Filtering, concentration
Merge extracting solution a and b, filtered with plate filter, filter cloth is 150 mesh, and filter vacuum concentration measures concentrated extract
Relative density be 1.40.
Step C：Allotment
Honey is weighed by formula to be added in the concentrated extract in step B, is stirred, then be charged with suitable
Dextrin stirs, and obtains mixed powder.
Step D：Granulation, drying
Mixed powder be added 30% Macrogol 4000 be made " hand pinch it is agglomerating, pressure it is i.e. scattered " softwood, then with fashion of extrusion
By 22 mesh screens (plate), uniform particle is made.Wet granular is placed in spray-drying process device it is dry, then with quick whole grain
Machine whole grain is obtained with the anti-inflammatory particle of clearing.
Embodiment 3
A kind of anti-inflammatory particle health products of clearing, including the extract of following raw material calculated in parts by weight, the place of production is river
7 parts aobvious of ampelopsis grossdentata of the Lichuan Counties Xi Sheng, 6 parts of honeysuckle, 5 parts of chrysanthemum, 3 parts of peppermint, 2 parts of Siraitia grosvenorii, 2 parts of the sterculia seed, toast
1 part of Radix Glycyrrhizae further includes 0.5 part of honey.
Referring to Fig.1, the preparation method of the anti-inflammatory particle of above-mentioned clearing, includes the following steps：
Step A extractions
Above-mentioned ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root are weighed accordingly respectively
It is put into togerther in gauze bag after amount, the gauze bag equipped with medicinal material is placed in the extractor equipped with ultrasonic wave, 12 times of medicinal materials are added
Extracting solution a is discharged in 75% ethyl alcohol of amount ultrasonic extraction 2.0 hours at a temperature of 60 DEG C, then into the extractor equipped with ultrasonic wave,
75% ethyl alcohol of 7 times of medicinal material amounts of addition ultrasonic extraction 1.0 hours at a temperature of 60 DEG C, discharge extracting solution b.
Step B filterings, concentration
Merge extracting solution a and b, filtered with plate filter, filter cloth is 150 mesh, and filter vacuum concentration measures concentrated extract
Relative density be 1.5.
Step D：Granulation, drying
Mixed powder be added 30% Macrogol 4000 be made " hand pinch it is agglomerating, pressure it is i.e. scattered " softwood, then with fashion of extrusion
By 22 mesh screens (plate), uniform particle is made.Wet granular is placed in spray-drying process device it is dry, then with quick whole grain
Machine whole grain is obtained with the anti-inflammatory particle of clearing.
Embodiment 4
A kind of anti-inflammatory particle health products of clearing, including the extract of following raw material calculated in parts by weight, the place of production is river
9 parts aobvious of ampelopsis grossdentata of the Lichuan Counties Xi Sheng, 3 parts of honeysuckle, 4 parts of chrysanthemum, 2.5 parts of peppermint, 1.5 parts of Siraitia grosvenorii, the sterculia seed 1.5
Part, 1.5 parts of honey-fried licorice root, further include 1.0 parts of honey.
Referring to Fig.1, anti-inflammatory particle of above-mentioned clearing and preparation method thereof；Including following preparation process：
Step A：Extraction
Above-mentioned ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root are weighed accordingly respectively
It is put into togerther in gauze bag after amount, the gauze bag equipped with medicinal material is placed in the extractor equipped with ultrasonic wave, 10 times of medicinal materials are added
Extracting solution a is discharged in 75% ethyl alcohol of amount ultrasonic extraction 2.0 hours at a temperature of 60 DEG C, then into the extractor equipped with ultrasonic wave,
75% ethyl alcohol of 6 times of medicinal material amounts of addition ultrasonic extraction 1.5 hours at a temperature of 60 DEG C, discharge extracting solution b.
Step B filterings, concentration
Merge extracting solution a and b, filtered with plate filter, filter cloth is 150 mesh, and filter vacuum concentration measures concentrated extract
Relative density be 1.45.
Step C：Allotment
The honey for weighing corresponding amount is added in the concentrated extract in step B, stirs, then is charged with appropriate
Dextrin, stir, obtain mixed powder.
Step D：Granulation, drying
Mixed powder be added 30% Macrogol 4000 be made " hand pinch it is agglomerating, pressure it is i.e. scattered " softwood, then with fashion of extrusion
By 22 mesh screens (plate), uniform particle is made.Wet granular is placed in spray-drying process device it is dry, then with quick whole grain
Machine whole grain is obtained with the anti-inflammatory particle of clearing.
Above-described embodiment, only presently preferred embodiments of the present invention, is not used for limiting the scope of the present invention, therefore all with this
The equivalent change or modification that feature and principle described in invention claim are done, should all be included in scope of the invention as claimed
Within.
The anti-inflammatory particle health products of the clearing of the present invention are subjected to zoopery
Materials and methods
1.1 experimental animal
16 week old SD rats 80, weight 180-220g, cleaning grade, half male and half female are real by Traditional Chinese Medicine University Of Guangzhou's medicine
Animal center offer, animal productiong licensing number are provided：SCXK (Guangdong) 2008-0020.
1.2 reagents and drug
The anti-inflammatory particle health products of clearing, the present invention are voluntarily prepared.
The anti-inflammatory particle dosage group of clearing：The anti-inflammatory particle 10g of clearing is weighed, distilled water is added to be settled to 100ml, adult's weight is pressed
60kg is calculated, and is converted into dosage 2g/kgbw, is equivalent to 10 times of human body recommended dose.
Aspirin enteric coated tablet (Jiangsu zero diopter pharmaceutical Co. Ltd product, specification：25mg, lot number：20100718)；
Dimethylbenzene (Beijing chemical reagent factory product, lot number：20091221)；
2,4-DNP (Sinopharm Chemical Reagent Co., Ltd.'s product, lot number：20100214)；
Carrageenan (Sigma Products).
1.3 experimental method
1.3.1 to rat fever solution to model heat effect caused by 2,4-DNP
Take SD rats 30, be randomly divided into 3 groups, i.e. blank control group (isometric physiological saline), positive drug control group (Ah
Take charge of a woods 0.1g/kg), the anti-inflammatory particle dosage group of clearing, every group 10, difference gastric infusion, successive administration 3d.Last dose
Before, measure each mouse anus temperature 1 time every 30min, continuous 2 times, be basic anus temperature with average value.30min after the last administration is pressed
10mg/kg dosage gives the 2,4-DNP solution pyrogenicity of a concentration of 15mg/ml in every mouse dorsal sc injection, respectively at
30 after pyrogenicity, 60,90min measure each mouse anus temperature 1 time, compare each group rat anus temperature situation of change
1.3.2 the swollen influence of rat ears caused by paraxylene
Take SD rats 30, be randomly divided into 3 groups, i.e. blank control group (isometric physiological saline), positive drug control group (Ah
Take charge of a woods 0.1g/kg), the anti-inflammatory particle dosage of clearing, every group 10, difference intraperitoneal injection, successive administration 7d.Last dose
30min afterwards is coated with dimethylbenzene 0.05ml/ only in the left ear of each mouse is two-sided, and auris dextra does not apply as a contrast, and mouse is put to death after 20min, cuts
Bottom left auris dextra is wide, and auricle, scales/electronic balance weighing, with a left side are taken respectively at left and right auricle same position with the card punch of a diameter of 6mm
Right two ear weight differences are swelling, calculate swelling inhibiting rate.Swelling inhibiting rate (%)=[(blank control group swelling-administration
Group swelling)/blank control group swelling] × 100%.
1.3.3 the influence of rat paw edema caused by Carrageenan
Take SD rats 30, be randomly divided into 3 groups, i.e. blank control group (isometric physiological saline), positive drug control group (Ah
Take charge of a woods 0.1g/kg), the anti-inflammatory particle dosage group of clearing, every group 10, intraperitoneal injection, successive administration 7d, last are given respectively
Before medicine, the left back sufficient volume of each mouse is measured and recorded with rat's foot volume measuring instrument, in the left back foot of every mouse after last dose 30min
Foot plantar is subcutaneously injected and gives 1% carrageenan 0.1ml, respectively at cause it is scorching after 0.5,1.0,2.0,3.0,4.0h holds with rat paw
Product measuring instrument measures and records left back sufficient volume each 2 times, takes its mean value calculation swelling rate.Swelling rate %=is [(after causing scorching rear left
Sufficient volume-cause inflammation front left metapedes volume)/cause scorching front left metapedes volume] × 100%.
2, experimental result
Rat fever solution to model heat effect caused by 2.1 pairs of 2,4- dinitrophenol
The experimental results showed that 2,4-DNP can obviously induced rat body temperature increase, the anti-inflammatory particle dosage group of clearing
Rat temperature raising is caused to have apparent inhibiting effect 2,4-DNP, compared with blank control group, difference all has
Statistical significance (equal P<0.05) and it is suitable with positive drug aspirin antipyretic response.It is shown in Table 1.
The anti-inflammatory particle of 1 clearing of table to 2,4-DNP cause rat fever solution to model heat effect (N=10)
Note：Compared with blank control group, ※ P<0.05
The influence of rat ear swelling caused by 2.2 paraxylene
The experimental results showed that dimethylbenzene obviously induced rat ear swelling, the anti-inflammatory particle group paraxylene of clearing can cause rat
Auricle acute inflammatory reaction has apparent inhibiting effect, and compared with blank control group, difference all has statistical significance (equal P<
0.05) and it is suitable with positive drug aspirin antiphlogistic effects.It is shown in Table 2.
The anti-inflammatory particle paraxylene of 2 clearing of table cause rat ears swelling rate influence (N=10)
| Group | Ear swelling degree (mg) | Swelling inhibiting rate (%) |
| Blank control group | 3.18±0.38 | - |
| Positive controls | 1.45±0.12※ | 54.57 |
| The anti-inflammatory particle of clearing | 1.47±0.17※ | 51.48 |
Note：Compared with blank control group, ※ P<0.05
The influence of rat paw edema caused by 2.3 Carrageenans
The experimental results showed that 1% carrageenan can obviously lure rat paw edema, 1% jiao of fork of the anti-inflammatory particle group pair of clearing
Rat paw edema inflammatory reaction caused by dish glue has apparent inhibiting effect, is all had with blank control group comparing difference
Statistical significance (equal P<0.05), suitable with positive drug aspirin antiphlogistic effects.It is shown in Table 3.
Rat paw edema caused by the anti-inflammatory particle health products Carrageenan of 3 clearing of table influence (N=10)
Note：Compared with blank control group, ※ P<0.05
Experiments prove that the anti-inflammatory particle of clearing has stronger its effect of antipyretic, anti-inflammatory effect and non-steroidal anti-inflammatory drugs
The effect of aspirin antipyretic and anti-inflammatory is suitable.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
The specific implementation of the present invention is confined to these explanations.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, architectural form cans be flexible and changeable, can be with derivative series product.It only makes several
Simple deduction or replace all shall be regarded as belonging to present invention scope of patent protection determined by the appended claims.
Claims (3)
1. a kind of preparation method of the anti-inflammatory particle health products of clearing, which is characterized in that including following preparation process：
Step A：Extraction
Ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root are weighed to the parts by weight in formula respectively,
Mixing is put into gauze bag；Gauze bag equipped with medicinal material is placed in the extractor equipped with ultrasonic wave, 10-12 times of medicinal material amount is added
75% ethyl alcohol ultrasonic extraction 1.5-2.0 hours at a temperature of 60 DEG C, extracting solution a is discharged；Again toward the extractor that ultrasonic wave is housed
Extracting solution b is discharged ultrasonic extraction 1.0-1.5 hours at a temperature of 60 DEG C in middle 75% ethyl alcohol that 6-8 times of medicinal material amount is added；
Step B：Filtering, concentration
Merge extracting solution a and extracting solution b, filtered with filter, filter vacuum concentration obtains relative density between 1.3-1.5
Concentrated extract；
Step C：Allotment
Honey is weighed by formula to be added in the concentrated extract obtained by step B, is stirred, then be charged with dextrin, is filled
Divide and stir evenly, obtains mixed powder；
Step D：Granulation, drying
Binder is added into mixed powder to be uniformly mixed, then uniform particle is made by 22 mesh screens with fashion of extrusion；General
Grain be placed in spray-drying process device it is dry, then with Fastgranulatemachine whole grain,
The ampelopsis grossdentata place of production is Jiangxi Province Lichuan County, and the filter is plate filter, and filter cloth is 150 mesh, institute
State ampelopsis grossdentata, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root, honey parts by weight be：
2. the preparation method of the anti-inflammatory particle health products of clearing as described in claim 1, which is characterized in that the binder is
30% Macrogol 4000.
3. the preparation method of the anti-inflammatory particle health products of clearing as described in claim 1, which is characterized in that Xian Chi snakes Portugal
Grape, honeysuckle, chrysanthemum, peppermint, Siraitia grosvenorii, the sterculia seed, honey-fried licorice root parts by weight be：
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| CN101690584A (en) * | 2009-09-07 | 2010-04-07 | 北京同仁堂健康药业股份有限公司 | Functional food and medicine for clearing throat and preparation method thereof |
| CN102266442A (en) * | 2011-07-08 | 2011-12-07 | 福州长富星新药开发有限公司 | Traditional Chinese medicine compound preparation for relieving cough and preparation process thereof |
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| CN101200684B (en) * | 2007-10-29 | 2011-05-11 | 新疆农业科学院综合试验场 | Health-care fragrant grape wine and method for preparing same |
| CN103005441A (en) * | 2012-12-20 | 2013-04-03 | 桂龙药业(安徽)有限公司 | Throat-clearing traditional Chinese medicinal health-care extract, preparation method thereof and health-care product prepared therefrom |
| CN104013667A (en) * | 2013-10-25 | 2014-09-03 | 湖北仙之灵食品有限公司 | Radix puerariae tablet |
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| CN102266442A (en) * | 2011-07-08 | 2011-12-07 | 福州长富星新药开发有限公司 | Traditional Chinese medicine compound preparation for relieving cough and preparation process thereof |
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