CN108244642A - A kind of compound Chinese medicinal preparation of pharynx-clearing throat-benefiting and preparation method thereof - Google Patents
A kind of compound Chinese medicinal preparation of pharynx-clearing throat-benefiting and preparation method thereof Download PDFInfo
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- CN108244642A CN108244642A CN201611249172.8A CN201611249172A CN108244642A CN 108244642 A CN108244642 A CN 108244642A CN 201611249172 A CN201611249172 A CN 201611249172A CN 108244642 A CN108244642 A CN 108244642A
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 235000020344 instant tea Nutrition 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 201000005264 laryngeal carcinoma Diseases 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
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- 238000012247 phenotypical assay Methods 0.000 description 1
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- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- 208000023504 respiratory system disease Diseases 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
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- 230000035807 sensation Effects 0.000 description 1
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- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
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- 229940072040 tricaine Drugs 0.000 description 1
- FQZJYWMRQDKBQN-UHFFFAOYSA-N tricaine methanesulfonate Chemical compound CS([O-])(=O)=O.CCOC(=O)C1=CC=CC([NH3+])=C1 FQZJYWMRQDKBQN-UHFFFAOYSA-N 0.000 description 1
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical group C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of compound Chinese medicinal preparations of pharynx-clearing throat-benefiting, are made of raw material and pharmaceutically acceptable auxiliary material, and the raw material is made of in terms of 1200 parts the component of following parts by weight：10~450 parts of honeysuckle, 10~250 parts of Radix Glycyrrhizae, 5~150 parts of the sterculia seed, 3~75 parts of dried orange peel, 5~150 parts of the root of Dahurain angelica, 2~55 parts of radix polygonati officinalis, 3~75 parts of mulberry leaf.A kind of pharynx-clearing throat-benefiting provided by the invention and moistening lung fall fire preparation, Formulation is scientific and reasonable, and according to theory of traditional Chinese medical science, scientific compatibility, the effect of to reach pharynx-clearing throat-benefiting, moistening lung fall fire, active ingredient combination can play synergistic effect；It is unique in taste, it is convenient to take, conducive to absorption, clear efficacy, be it is a can the edible multi-selection product of medicine.
Description
Technical field
The present invention relates to a kind of food and field of health care food, more particularly to a kind of that there is pharynx-clearing throat-benefiting, elimination throat to swell
Bitterly, moistening lung fall fire, compound Chinese medicinal preparation of invigorating the spleen qi-regulating and preparation method thereof.
Background technology
Sphagitis is ear-nose-throat department the most common type disease, is under pharyngeal mucosa, mucous membrane and the diffusivity of lymphoid tissue
Inflammation, often have dry, itch, is scorching hot, the symptoms such as hypodynia, foreign body sensation and hoarseness.Smoking is lead to pharyngolaryngitis No.1
" killer ", shows according to investigations, and the sphagitis incidence of smoker is up to 31.2%, and non-smoker is only 8.6%, and patients with laryngeal carcinoma has
Smoking history accounts for more than 90%.In addition, as air pollution is increasingly severe, haze sky is also more and more, the infringement to people
It is increasingly severe.Sulfur dioxide, nitrogen oxides, pellet (PM10) and fine particle (PM2.5) are the main of haze
Constituent, it can be directly entered and be adhered in human body pharyngeal mucosa, respiratory tract and alveolar, cause sphagitis, acute rhinitis
With the illnesss such as acute bronchitis.For pharyngo-laryngitis chronica, bronchial asthma, chronic bronchitis, obstructive emphysema and slow
Patients with chronic diseases, the haze weathers such as property obstructive disease of lung can make state of an illness acute attack or acute exacerbation[1]。
Chronic pharyngitis is the chronic inflammation of pharyngeal mucous membrane, submucosa and lymphoid tissue, and the pathogenic factor of chronic pharyngitis is very
It is more, as acpuei pharyngitis recurrent exerbation and adjacent organs disease cause.In addition, very cold is dried, dust, chemical gas, tobacco and wine
Chronic pharyngitis is all susceptible to suffer from the excessive people of throat with pungent diet long-time stimulus and due to occupational factor, in addition, long-term life
Irregular, fatigue is nervous, can decline passive protective physical fitness, and bacterium and the easy repeated infection of virus can also cause chronic pharynx
It is scorching.There are many method for the treatment of chronic pharyngitis at present, the gargles such as opinion Dobell's solution as doctor trained in Western medicine, buccal Hua Su
Piece, Anji lozenge etc., but the long-time service of these drugs can cause internal environment of oral cavity disorderly, and curative effect is not highly desirable.Clinically
It is less because bacterium causes, therefore use antibiotic therapeutic effect it is not good enough, most of patients using it is pharyngeal part be atomized, freezing, microwave or
The treatments such as laser ablation, although itching to pharynx, the symptoms such as foreign body in pharynx sense make moderate progress, because destroy mucous membrane glandular secretion and
The reasons such as scar contraction frequently can lead to pharyngalgia, dry throat aggravates.Furthermore it takes antibiotic for a long time, drug resistance can be generated, and have
Side effect, long-time service are unfavorable for health.
Theory of traditional Chinese medical science thinks, swallows the pass for stomach, and larynx is the door of lung, and the heresies of diseases caused by external factors enters lung and easily hinders larynx, it is improper diet enter stomach it is easy
It damages in pharynx, throat invades well the ground stayed for a long time for cult poison.The traditional Chinese medical science thinks that throat illness is related with visceral dysfunction, wind-heat affecting lung, spleen
Losing strong fortune, stomach Qi weakness etc. can cause, and it is method to prevent that clearing heat and detoxicating, regulating qi-flowing for eliminating phlegm can be used, and in the treatment, traditional Chinese medicine is shown
Go out sizable advantage, also very big potentiality can be dug.
Zebra fish is a kind of common tropical fish, and due to raising, easy, embryo is transparent, in vitro fertilization, mutant variety is more, heredity
Many advantages, such as tool is ripe has become the emerging model animal of new drug development in recent years.Due to zebra fish gene and the mankind
The similarity of gene reaches 87%, it means that the obtained result of drug study is done with it and is also suitable in most cases
In human body[2-10].Zebra fish inflammatory factor and the homology of the mankind are very high, and inflammation mechanism is highly consistent with mammal, using spot
The evaluation and screening study of horse fish inflammatory model progress anti-inflammatory drug are very extensive[11-16].In addition, the serious crowd that smokes suffers from
Generally with bronchial asthma while sphagitis, bronchial asthma is a kind of air flue dysfunction disease, and treatment is mainly with slow
It solves based on bronchial muscular spasm, that is, evaluates inhibiting effect of the drug to smooth muscle contraction.
In the product or patent of presently commercially available pharynx-clearing throat-benefiting and moistening lung fall fire, unclear there are pharmacological mechanism, effect
Imprecise, there are the deficiencies of security risk for long-term use.Such as the Chinese invention patent of Publication No. CN201110089466.X,
A kind of throat-clearing health-care tea is disclosed, main component is：Tealeaves, the sterculia seed, Radix Glycyrrhizae, radix scrophulariae, Radix Ophiopogonis, honeysuckle, Radix Isatidis,
Chrysanthemum.The for another example Chinese invention patent of Publication No. CN201410256704.5 discloses a kind of pharynx-clearing throat-benefiting preparation and its system
Preparation Method, main component are：Honeysuckle, wild chrysanthemum or chrysanthemum, dark plum, campanulaceae, lophatherum gracile, Radix Glycyrrhizae, peppermint, hawthorn, radix scrophulariae,
Blackberry lily, rhizoma imperatae, radix scutellariae, Radix Ophiopogonis, cicada slough.The for another example Chinese invention patent of Publication No. CN20150226164.0, discloses one
The Chinese medicine composition for effect of relieving inflammation or internal heat with pharynx-clearing throat-benefiting and moistening lung is planted, main component is：Chrysanthemum, the sterculia seed, honeysuckle, arhat
Fruit, lotus nut, dried orange peel, radix polygonati officinalis, lophatherum gracile, kuh-seng, the fruit of Chinese wolfberry, radix scrophulariae, moutan bark, Radix Glycyrrhizae, coloured malt, bitter orange flower, rush.
The for another example Chinese invention patent of Publication No. CN201510683558.9 discloses a kind of with pharynx-clearing throat-benefiting moistening lung effect
Preparation, main component is：Bulbus Fritillariae Thunbergii extract, American ginseng extract, ophiopogon japonicus extract, Fructus Monordicae extract, radix bardanae, blueness
Fruit, Honegsukle flower P.E, Jumi extract, pyrus nivalis, loquat, menthol, vitamin C, isomaltoketose.Aforementioned patent literature institute
The pharynx-clearing throat-benefiting preparation being related to, pharmacological mechanism is unclear, did not also make anti-inflammatory efficacy and smooth muscle contraction inhibits to make
With evaluation.
To sum up, how to provide a kind of pharmacological mechanism clearly and really effectively can prevent rather than be based only on the traditional Chinese medical science
The pharynx-clearing throat-benefiting of theory, the product of moistening lung fall fire are that those skilled in the art are badly in need of the technical barrier solved.
Invention content
Present invention aims at providing, a kind of therapeutic effect is definite, toxic side effect is small, takes securely and reliably with clearing profit
The compound Chinese medicinal preparation and preparation method thereof of larynx, moistening lung fall fire solves and above-mentioned is previously mentioned related defects in the prior art.
In the present invention, inventor is in early period to the raw material of 20 kinds of integration of drinking and medicinal herbs enumerated according to health food regulation and 5 kinds
New resource food carries out effect screening, by zebra fish it is anti-inflammatory and inhibit smooth muscle contraction experiment test, find：In 25 kinds of raw materials
There are 11 both without anti-inflammatory efficacy or unrestraint smooth muscle shrinks function, 5 only have anti-inflammatory efficacy, and 2 only have inhibition smoothly
Flesh shrink effect, 7 have both anti-inflammatory efficacy and inhibit smooth muscle contraction effects, material name be respectively honeysuckle, Radix Glycyrrhizae,
The sterculia seed, dried orange peel, the root of Dahurain angelica, radix polygonati officinalis and mulberry leaf；Finally, on this basis, inventor passes through Formulation, screening, allotment, exploitation
The compound Chinese medicinal preparation with synergistic function is gone out.
For achieving the above object, technical solution is specially：
A kind of compound Chinese medicinal preparation of pharynx-clearing throat-benefiting, is made of raw material and pharmaceutically acceptable auxiliary material, the raw material
In terms of 1200 parts, it is made of the component of following parts by weight：10~450 parts of honeysuckle, 10~250 parts of Radix Glycyrrhizae, the sterculia seed 5~150
Part, 3~75 parts of dried orange peel, 5~150 parts of the root of Dahurain angelica, 2~55 parts of radix polygonati officinalis, 3~75 parts of mulberry leaf.
Preferably, the raw material is made of the component of following parts by weight：15~400 parts of honeysuckle, Radix Glycyrrhizae 10~200
Part, 5~100 parts of the sterculia seed, 3~60 parts of dried orange peel, 5~100 parts of the root of Dahurain angelica, 2~50 parts of radix polygonati officinalis, 3~60 parts of mulberry leaf.
Preferably, extract powder is made in each component in a manner of extraction in the raw material, and preparation method is as follows：Take prescription
The raw material components of amount, extracting in water n times merge the extracting solution that extracts every time, filter, and are concentrated under reduced pressure, be spray-dried to get.
It is furthermore preferred that in the raw material extract powder extraction process, times N >=2 of extraction, extraction time is 1~4 small
When.
It is furthermore preferred that in the raw material extract powder extraction process, Extraction solvent is selected from water, ethyl alcohol, chloroform, acetone, second
One or more of acetoacetic ester, methanol.
It is furthermore preferred that each raw material extract powder, is made respectively by following extracting method：
1) honeysuckle：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the quantity of solvent added by first time extracting in water is
6~30 times of amount of medicinal material weight, the solvent added for the second time are 5~25 times of medicinal material weight, merge extracting solution, filter, decompression
Concentration, spray drying, obtains honeysuckle concrete powder；
2) Radix Glycyrrhizae：It takes in right amount, adds extraction 2 times, 1~4 hour every time, for the first time plus the quantity of solvent added by extraction with aqueous solution was
6~30 times of amount of medicinal material weight, the solvent added for the second time are 6~25 times of medicinal material weight, merge extracting solution, filter, decompression
Concentration, spray drying, obtains Radix Glycyrrhizae extractum powder；
3) sterculia seed：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the water added by first time extracting in water was medicine
6~20 times of water of material weight, the water added for the second time are 5~15 times of medicinal material weight, merge extracting solution, filter, decompression
Concentration, spray drying, obtain sterculia seed extract powder；
4) dried orange peel：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the quantity of solvent added by first time extracting in water was medicine
6~30 times of amount of material weight, the solvent added for the second time are 5~25 times of medicinal material weight, merge extracting solution, and filtration is depressurized dense
Contracting, spray drying, obtains dried orange peel extract powder；
5) root of Dahurain angelica：It takes in right amount, adds extraction 2 times, 1~4 hour every time, for the first time plus the quantity of solvent added by extraction with aqueous solution was
6~30 times of amount of medicinal material weight, the solvent added for the second time are 6~25 times of medicinal material weight, merge extracting solution, filter, decompression
Concentration, spray drying, obtains root of Dahurain angelica extract powder；
6) radix polygonati officinalis：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the water added by first time extracting in water was medicinal material
6~20 times of water of weight, the water added for the second time are 5~15 times of medicinal material weight, merge extracting solution, and filtration is depressurized dense
Contracting, spray drying, obtain radix polygonati officinalis extract powder；
7) mulberry leaf：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the water added by first time extracting in water was medicinal material
6~20 times of water of weight, the water added for the second time are 5~15 times of medicinal material weight, merge extracting solution, and filtration is depressurized dense
Contracting, spray drying, obtain mulberry extract powder.
Seven kinds of aforementioned folk prescription extracts are uniformly mixed, powder, tablet, capsule, particle are finally made according to a conventional method
Agent, pill, tea bag instant tea, water drink or oral liquid etc., these cannot be used for limiting the scope of the invention.
Preferably, the pharmaceutically acceptable auxiliary material is made of corrigent, binder and lubricant, wherein corrigent
For one kind in white granulated sugar, PEARLITOL 25C sugar, citric acid, juice of Fructus vaccini vitis-idaeae powder, strawberry fruit juice powder, kumquat juice powder, peppermint oil or
It is several；Binder is maltodextrin, starch, gelatin, sodium carboxymethylcellulose, hydroxypropyl cellulose, methylcellulose, ethyl are fine
One or more of dimension element, hydroxypropyl methyl cellulose；Lubricant is magnesium stearate, superfine silica gel powder, talcum powder and titanium dioxide
One or more of silicon.
It is furthermore preferred that the pharmaceutically acceptable auxiliary material is made of corrigent, binder and lubricant, wherein flavoring
Agent is white granulated sugar, PEARLITOL 25C sugar, juice of Fructus vaccini vitis-idaeae powder, citric acid and peppermint oil, and binder is maltodextrin, and lubricant is tristearin
Sour magnesium.
It is furthermore preferred that the pharmaceutically acceptable auxiliary material, is made of following components by weight：White granulated sugar 35
~400 parts, PEARLITOL 25C sugar is 20~350 parts, and maltodextrin is 10~150 parts, and magnesium stearate is 10~162 parts, blueberries
10~50 parts of juice powder, 5~40 parts of citric acid, 5~10 parts of peppermint oil.
Preferably, a kind of compound Chinese medicinal preparation of pharynx-clearing throat-benefiting, is made of raw material and pharmaceutically acceptable auxiliary material, described
Raw material be made of the component of following parts by weight：120 parts of honeysuckle, 60 parts of Radix Glycyrrhizae, 30 parts of the sterculia seed, 15 parts of dried orange peel, the root of Dahurain angelica 12
Part, 8 parts of radix polygonati officinalis, 12 parts of mulberry leaf；The auxiliary material is made of the component of following parts by weight：335 parts of white granulated sugar, PEARLITOL 25C sugar are
220 parts, maltodextrin is 143 parts, and magnesium stearate is 150 parts, 50 parts of juice of Fructus vaccini vitis-idaeae powder, 40 parts of citric acid, 5 parts of peppermint oil.
The prescription principle and advantage of the present invention is as follows：
1st, honeysuckle, Radix Glycyrrhizae, the sterculia seed, dried orange peel, the root of Dahurain angelica, radix polygonati officinalis and mulberry leaf are to be embodied in 2015 editions in prescription《China
Pharmacopeia》Medical and edible dual purpose plant, be easy to get, and without any toxicity, seven taste Chinese medicines are at 2015 editions《Chinese Pharmacopoeia》In work(
Can with cure mainly it is specific as follows：
Honeysuckle：It is clearing heat and detoxicating, dispelling wind and heat from the body.For carbuncle swells furunculosis, larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, temperature
Disease fever.
Radix Glycyrrhizae：It invigorates the spleen and benefits qi , Cheongju thermal detoxifications, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, burnout is weary
Power, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
The sterculia seed：Clearing heat and moistening lung, relieving sore-throat open sound, relax bowel.For lung heat celostomia, dry cough without phlegm, pharyngodynia with dryness, thermojunction
Just it closes, headache and hot eyes.
Dried orange peel：Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For abdominal fullness and distention, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
The root of Dahurain angelica：Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping declare clearing the nasal passage, eliminating dampness stops band, detumescence and apocenosis, for cold headache, superciliary ridge
Bitterly, nasal congestion, allergic rhinitis, nasosinusitis, toothache, under, sore swell and ache curative.
Radix polygonati officinalis：Nourishing yin to moisten dryness promotes the production of body fluid to quench thirst.Hinder for lung stomach-Yin, cough caused by dryness-heat, dry throat and mouth, Heat Diabetes.
Mulberry leaf：Dispelling wind and heat from the body, clearing away the lungheat and moisturizing are clear liver and improved vision.For anemopyretic cold, lung-heat type cough, dizziness headache, hot eyes dusk
Flower.
2nd, honeysuckle, Radix Glycyrrhizae, the sterculia seed, dried orange peel, the root of Dahurain angelica, radix polygonati officinalis and mulberry leaf are the Chinese medicine for walking lung channel, to throat and are exhaled
Desorption system disease has the effect of definite, this point in《Chinese Pharmacopoeia》Described in, but do not recorded in seven aforementioned tastes in pharmacopeia
Medical instrument has anti-inflammatory efficacy and inhibits smooth muscle shrinks function effect.
Applicant of the present invention has found after zebra fish experiment screening prescription, in throat after aforementioned seven tastes Chinese medicine is combined
With there is notable drug effect in respiratory disease particularly smoking population, specific manifestation is as follows：1. clear efficacy passes through zebra fish
Anti-inflammatory efficacy and inhibition smooth muscle shrinks function evaluation experimental find that invention formulation has apparent anti-inflammatory efficacy and inhibits to put down
The effect that flesh is shunk is slided, each folk prescription shows certain anti-inflammatory efficacy and inhibits the effect of smooth muscle contraction, but compound preparation
Effect is significantly better than seven simples, illustrates that preparation plays the role of cooperateing with anti-inflammatory and inhibition smooth muscle contraction；2. through zebra fish reality
Verification is real to have no toxic side effect；3. after human body is taken, feel throat it is salubrious, it is comfortable, moist, return sweet, clearing heat and eliminating phlegm, clear away heart-fire and remove
It is tired, there is apparent pharynx-clearing throat-benefiting healthcare function.
3rd, present invention applicant carries out anti-inflammatory efficacy peace using transgenosis neutrophil leucocyte fluorescence zebra fish inflammatory model
Sliding flesh shrinks inhibiting effect evaluation, and the simple of pharynx-clearing throat-benefiting and moistening lung fall fire and evaluation composing prescription preparation are screened based on experimental evidence
The effect of, observation is intuitive, and analysis is easy, as a result objective reliable.
In short, a kind of compound Chinese medicinal preparation of pharynx-clearing throat-benefiting provided by the invention, Formulation is scientific and reasonable, according to experiment
Evidence scientific compatibility, the effect of to reach pharynx-clearing throat-benefiting, moistening lung fall fire, active ingredient combination can play synergistic effect；
It is unique in taste, it is convenient to take, conducive to absorption, clear efficacy, be it is a can the edible multi-selection product of medicine.
Description of the drawings
Fig. 1 promotes inflammatory resolution to act on qualitative evaluation phenotypic map for invention formulation.
Fig. 2 promotes inflammatory resolution to act on each experimental group neutrophil numbers for invention formulation.
Fig. 3 is invention formulation inflammatory resolution rate.
Fig. 4 inhibits smooth muscle contraction (enterocinesia) qualitative evaluation phenotypic map for invention formulation.
Fig. 5 inhibits smooth muscle contraction (enterocinesia) inhibiting rate for invention formulation.
Specific embodiment
The following is specific embodiments of the present invention, and technical scheme of the present invention is further described, but of the invention
Protection domain be not limited to these embodiments.It is every to be included in this hair without departing substantially from the change of present inventive concept or equivalent substitute
Within bright protection domain.
Embodiment 1：The screening of simple in invention formulation composition
1st, experimental animal
Transgenosis neutrophil leucocyte fluorescence zebra fish and wild type AB systems zebra fish, are trained under the conditions of 28 DEG C with fish culture water
(breeding fish) is supported with water water quality：200mg Instant Oceans are added in per 1L reverse osmosis waters, conductivity is 480~510 μ S/cm；PH is
6.9~7.2；Hardness is 53.7~71.6mg/L CaCO3).4~5 pairs of zebra fish parent mating are taken, according to Westerfield
[17] method hatched blastocyst.After the completion of experiment, over-exposure processing is carried out with the zebra fish of tricaine methanesulfonic acid pair, thus will
Zebra fish anesthesia is put to death.The operating procedure that anesthesia is put to death meets the specification that American Veterinary association (AVMA) puts to death Animal Anesthesia will
It asks.
2nd, tested material
The raw material and 5 kinds of new resource foods of 20 kinds of integration of drinking and medicinal herbs.
3rd, laboratory apparatus and reagent
Disecting microscope (SMZ645, Nikon company)；6 orifice plates (Nest Biotech)；Microinjection instrument (IM300,
Narishige)；Indomethacin (13931, Aladdin).
4th, experimental method
4.1 anti-inflammatory efficacies are evaluated
150 tail transgenosis neutrophil leucocyte fluorescence zebra fish are chosen in six orifice plates, it is water-soluble respectively to give 25 per 30 tail of hole
Kind tested material, concentration is 1mg/mL, while sets 25 μ g/mL concentration of Normal group and positive controls Indomethacin.Place
It is water-soluble to give derivant copper sulphate after managing 1h.After being jointly processed by 2h, every group is selected 10 tail zebra fish at random, with Nikon NIS-
3.10 high visions of Elements D processing software carries out image analysis, calculates in zebra fish inflammation part (acoustic cell region)
Property granulocyte quantity (N), carry out quantitative analysis, statistical procedures result useIt represents；The effect of K5 inflammatory resolutions calculates public
Formula is as follows：
4.2 inhibit smooth muscle shrinks function evaluation
120 tail wild type AB systems zebra fish are chosen, the yolk powder of 10mg/mL is fed, is eluted after 3h, zebra fish is placed in six
In orifice plate, per hole 30 tail, it is water-soluble give it is water-soluble respectively give formula 1, formula 2, formula 3, formula 4, concentration is 1mg/mL, together
When set 1200 μ g/mL concentration of Normal group and positive controls atropine.After handling 1d, every group is selected 10 tail zebras at random
Fish, under a dissecting microscope observe enteron aisle fill yolk powder, take pictures and preserve；Image analysis is carried out with image processing software,
Enteron aisle light obscuration summation (S) is calculated, unit is：Pixel value.Statistical procedures result is represented with X ± SE；Suppression to enterocinesia
Making calculation formula is as follows：
5th, experimental result
It screens and obtains from the raw material and 5 kinds of new resource foods of 20 kinds of integration of drinking and medicinal herbs, it is anti-inflammatory and inhibit smooth through zebra fish
Flesh is shunk it is experimentally confirmed that having 11 in 25 kinds of raw materials both without anti-inflammatory efficacy or unrestraint smooth muscle shrinks function, 5 only with anti-
Scorching effect, 2 only have the function of to inhibit smooth muscle contraction, and the effect of 7 anti-inflammatory efficacies and inhibition smooth muscle contraction has concurrently, former
Expect that title is respectively honeysuckle, Radix Glycyrrhizae, the sterculia seed, dried orange peel, the root of Dahurain angelica, radix polygonati officinalis and mulberry leaf.
Embodiment 2：The preparation of each raw material components in invention formulation
In the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting provided by the invention, raw material is by honeysuckle, Radix Glycyrrhizae, the sterculia seed, dried orange peel, white
The root of Dahurian angelica, radix polygonati officinalis and mulberry leaf extract respectively, are obtained by mixing, and the extraction step difference of each raw material components is as follows：
By prescription extracting honeysuckle 500g, 70% ethanol water is added to extract 2 times, 2 hours every time, adds 70% ethyl alcohol for the first time
Quantity of solvent added by extraction with aqueous solution is 12 times of medicinal material weight, and the quantity of solvent added for the second time is 10 times of medicinal material weight, is merged
Extracting solution filters, and is concentrated under reduced pressure, dry, obtains dried object 128g, as honeysuckle concrete powder.
By prescription extracting liquorice 300g, 60% ethanol water is added to extract 2 times, 2 hours every time, adds 60% ethanol water for the first time
The added quantity of solvent of solution extraction is 15 times of medicinal material weight, and the quantity of solvent added for the second time is 12 times of medicinal material weight, and merging carries
Liquid is taken, is filtered, is concentrated under reduced pressure, it is dry, obtain dried object 29.4g, as Radix Glycyrrhizae extractum powder.
Sterculia seed 100g is taken by prescription, extracting in water 2 times is secondary to extract 2 hours, and the water added by first time extracting in water is
8 times of medicinal material weight, the water added for the second time are 8 times of medicinal material weight, merge extracting solution, and filtration is concentrated under reduced pressure, drying, obtains
Dried object 33.4g, as sterculia seed extract powder.
Dried orange peel 100g is taken by prescription, extracting in water 2 times, secondary extraction 2 hours, the water added by first time extracting in water is medicine
8 times of material weight, the water added for the second time are 5 times of medicinal material weight, merge extracting solution, and filtration is concentrated under reduced pressure, drying, obtains dry
Dry object 22.3g, as dried orange peel extract powder.
Root of Dahurain angelica 100g is taken by prescription, extracting in water 2 times, secondary extraction 2 hours, the water added by first time extracting in water is medicine
10 times of material weight, the water added for the second time are 5 times of medicinal material weight, merge extracting solution, and filtration is concentrated under reduced pressure, drying, obtains dry
Dry object 18.6g, as root of Dahurain angelica extract powder.
Radix polygonati officinalis 100g is taken by prescription, extracting in water 2 times, secondary extraction 2 hours, the water added by first time extracting in water is medicine
10 times of material weight, the water added for the second time are 5 times of medicinal material weight, merge extracting solution, and filtration is concentrated under reduced pressure, drying, obtains dry
Dry object 19.5g, as radix polygonati officinalis extract powder.
Mulberry leaf 100g is taken by prescription, extracting in water 2 times, secondary extraction 2 hours, the water added by first time extracting in water is medicine
10 times of material weight, the water added for the second time are 5 times of medicinal material weight, merge extracting solution, and filtration is concentrated under reduced pressure, drying, obtains dry
Dry object 15.7g, as mulberry extract powder.
Embodiment 3：
By formula extracting honeysuckle 500g, Radix Glycyrrhizae 300g, sterculia seed 100g, dried orange peel 100g, root of Dahurain angelica 100g, radix polygonati officinalis 100g and mulberry
Leaf 100g, extracting in water 2 times, 2 hours every time, the water added by first time extracting in water was 12 times of medicinal material weight, second
The water added is 10 times of medicinal material weight, merges extracting solution, and filtration is concentrated under reduced pressure, spray drying, obtains extract powder 387g.
Embodiment 4：
Formula 1：In terms of 1200 parts,
Preparation process：It is prepared by 3 method of embodiment, takes the above-mentioned raw materials and auxiliary material of recipe quantity, mix, sieving, directly
Tabletting to get.Piece weight is 0.5g.
Embodiment 5：
Formula 2：In terms of 1200 parts,
Preparation process：It is prepared by 3 method of embodiment, takes the above-mentioned raw materials and auxiliary material of recipe quantity, mix, sieving, directly
Tabletting to get.Piece weight is 0.5g.
Embodiment 6：
Formula 3：In terms of 1200 parts,
Preparation process：It is prepared by 3 method of embodiment, takes the above-mentioned raw materials and auxiliary material of recipe quantity, mix, sieving, directly
Tabletting to get.Piece weight is 0.5g.
Embodiment 7：
Formula 4：In terms of 1200 parts,
Preparation process：It is prepared by 3 method of embodiment, takes the above-mentioned raw materials and auxiliary material of recipe quantity, mix, sieving, directly
Tabletting to get.Piece weight is 0.5g.
Embodiment 8：The anti-inflammatory effect evaluation experimental of compound Chinese medicinal preparation of the present invention
1st, experimental animal
With embodiment 1.
2nd, tested material
Formula 1, formula 2, formula 3, formula 4.
3rd, laboratory apparatus and reagent
Disecting microscope (SMZ645, Nikon company)；6 orifice plates (Nest Biotech)；Microinjection instrument (IM300,
Narishige)；Indomethacin (13931, Aladdin).
4th, experimental method
150 tail transgenosis neutrophil leucocyte fluorescence zebra fish are chosen in six orifice plates, per 30 tail of hole, water-soluble give is matched respectively
Side 1, formula 2, formula 3, formula 4, concentration is 1mg/mL, while sets Normal group and positive controls Indomethacin 25
μ g/mL concentration.Remaining is the same as 4.1 parts in embodiment 1.
5th, experimental result
Model control group inflammation part (acoustic cell region) neutrophil leucocyte quantity (16.0) and Normal group (2.2
It is a) compare p<0.001, show model foundation success.Positive controls Indomethacin inflammation part neutrophil leucocyte quantity (7.8
It is a) p compared with model control group<0.001, illustrate that Indomethacin has anti-inflammatory effect, inflammatory resolution rate is 69%.Formula 1 is matched
Square 2, the inflammation part neutrophil leucocyte quantity for being formulated 3, formula 4 is respectively 6.5,11.2,10.3 and 7.5, inflammatory resolution rate
Respectively 78%, 45%, 52% and 72%, the p compared with model control group<0.001, show formula 1, formula 2, formula 3, formula
4 are respectively provided with apparent anti-inflammatory effect, the anti-inflammatory efficacy evaluations of 4 preparations being ordered as from high to low：Formula 1>Formula 4>Formula 3
>It is formulated 2 (being shown in Table 1, Fig. 1, Fig. 2, Fig. 3).
The anti-inflammatory effect evaluation of 1. 4 formulas of table
Compared with model control group, * * * p<0.001
Embodiment 9：The evaluation experimental of the inhibition smooth muscle contraction of invention formulation compound Chinese medicinal preparation
1st, experimental animal
With embodiment 1.
2nd, tested material
Formula 1, formula 2, formula 3, formula 4.
3rd, laboratory apparatus and reagent
Disecting microscope (SMZ645, Nikon company)；6 orifice plates (Nest Biotech)；Yolk powder (is raised in Beijing Katyuan
Expect Co., Ltd)；Microinjection instrument (IM300, Narishige).
4th, experimental method
120 tail wild type AB systems zebra fish are chosen, the yolk powder of 10mg/mL is fed, is eluted after 3h, zebra fish is placed in six
In orifice plate, per hole 30 tail, it is water-soluble give it is water-soluble respectively give formula 1, formula 2, formula 3, formula 4, concentration is 1mg/mL, together
When set 1200 μ g/mL concentration of Normal group and positive controls atropine.Remaining is the same as 4.2 parts in embodiment 1.
5th, experimental result
Yolk powder is filled in model control group zebra fish enteron aisle, grey black is shown as under disecting microscope.Positive control Ah
The yolk powder that tropine group enteron aisle fills is more than Normal group, enteron aisle light obscuration summation (10647 pixel) and model control group
(7889 pixel) compares p<0.01, enterocinesia inhibiting rate is 34.9%, shows that atropine can significantly inhibit zebra fish enterocinesia,
Have the function of to inhibit smooth muscle contraction.Formula 1, formula 2, formula 3, be formulated 4 enteron aisle light obscuration summation be respectively 9952,
9300th, 9565 and 9720 pixel, enterocinesia inhibiting rate is respectively 26.1%, 17.9%, 21.2% and 23.2%, with model comparison
Group is compared to p<0.05, show that formula 1, formula 2, formula 3, formula 4 are respectively provided with apparent smooth muscle contraction inhibiting effect, 4 systems
The smooth muscle contraction of agent inhibits effect being ordered as from high to low：Formula 1>Formula 4>Formula 3>Formula 2 (is shown in Table 2, Fig. 4, figure
5)。
The smooth muscle contraction inhibiting effect evaluation of 2. 4 formulas of table
Compared with model control group, * p<0.05, * * p<0.01
Embodiment 10：The human trial of the pharynx-clearing throat-benefiting, moistening lung fall fire of compound Chinese medicinal preparation of the present invention
Give 30 clinics that there are the smoking populations such as pharyngodynia with dryness, dry cough respectively formula 1, formula 2, formula 3, formula 4, often
Individual counts effect after continuously eating 3 days, 3 days.Following table is human test results：
The human test results of 3. 4 formulas of table
| Group | Experiment number | Edible time | Efficiently individual quantity | Invalid number | It is efficient |
| Formula 1 | 30 | 3 | 29 | 1 | 96.7% |
| Formula 2 | 30 | 3 | 26 | 4 | 86.7% |
| Formula 3 | 30 | 3 | 27 | 3 | 90% |
| Formula 4 | 30 | 3 | 28 | 2 | 93.3% |
As can be seen from the above table：Embodiment 4~7 prepare gained preparation to smoking population it is efficient 90% with
On, there is good pharynx-clearing throat-benefiting, moistening lung fall fire.
It is attached：Bibliography
[1] it is gorgeous more than, progress [J] Medical reviews of Cao hall blueness acute lung injury medicament protections, 2008,14
(21):3284-3288.[2]McGrath P,Li CQ.Zebrafish:a predictive model for assessing
drug-induced toxicity[J].Drug Discov Today,2008,13:394-401.
[3]He J H,Guo S Y,Zhu F,et al.A zebrafish phenotypic assay for
assessing drug-induced hepatotoxicity[J].J Pharmacol Toxicol Methods,2013,67:
25-32.
[4]Yang R,Lao QC,Yu HP,et al.Tween-80and Impurity Induce
Anaphylactoid Reaction in Zebrafish[J].J Appl Toxicol,2015,35:295-301.
[5]Xu M,Lao QC,Zhao P,et al.6′-O-Caffeoylarbutin inhibits
melanogenesis in zebrafish[J].Nat Prod Res,2014,28:932-934.
[6]Zhou J,Guo S Y,Zhang Y,et al.Human prokinetic drugs promote
gastrointestinal motility in zebrafish[J].Neurogastroenterol Motil,2014,26:
589-595.
[7]Zhu J J,Xu Y Q,He J H,et al.Human cardiotoxic drugs delivered by
soaking and microinjection induce cardiovascular toxicity in zebrafish[J].J
Appl Toxicol,2014,34:139-148.
[8]Zhou J,Xu YQ,Guo SY,Li CQ.Rapid analysis of hypolipidemic drugs in
a live zebrafish assay.J Pharmacol Toxicol Methods,2015,72:47-52.
[9]Li JL,Zhou J,Chen ZH,et al.Bioactive C 21Steroidal Glycosides from
the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor
Activity of Zebrafish Caused by Pentylenetetrazole.J Nat Prod.2015,24；78(7):
1548-1555.
[10]Xu H,Dong X,Zhang Z,et al.Assessment of immunotoxicity of dibutyl
phthalate using live zebrafish embryos.Fish&Shellfish Immunology,2015,45:286-
292.
[11]Christine W,Viviana G,Rebecca J,et al.A high-throughput
chemically induced inflammation assay in zebrafish[J].2010.8(1):151.
[12]Traver D,Herbomel P,Patton EE,et al.The zebrafish as a model
organism to study develop-ment of the immune system[J].Advances in
immunology,2003(81):253-330.
[13]Lam SH,Chua HL,Gong Z,et al.Development and maturation of the
immune system in zebrafish,Danio rerio:a gene expression profiling,in situ
hybridization and immunological study[J].Developmental&Comparative
Immunology,2004,28(1):9-28.
[14]Rhodes J,Hagen A,Hsu K,et al.Interplay of pu.1 and gata1
determines myeloerythroid progenitor cell fate in zebrafish[J].Developmental
cell,2005,8(1):97-108.
[15]Zhang Y,Bai XT,Zhu KY,et al.In vivo interstitial migration of
primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling
in response to acute injury[J].The Journal of Immunology,2008,181(3):2155-
2164.
[16]Mathias JR,Perrin BJ,Liu TX,et al.Resolution of inflammation by
retrograde chemotaxis of neutrophils in transgenic zebrafish[J].Journal of
leukocyte biology,2006,80(6):1281-1288.
[17]Westerfield M.The Zebrafish Book:A Guide for the Laboratory Use
of Zebrafish.Eugene,Oregon:The University of Oregon Press,1993.
Claims (10)
1. a kind of compound Chinese medicinal preparation of pharynx-clearing throat-benefiting, is made of raw material and pharmaceutically acceptable auxiliary material, the raw material with
1200 parts of meters, are made of the component of following parts by weight：10~450 parts of honeysuckle, 10~250 parts of Radix Glycyrrhizae, 5~150 parts of the sterculia seed,
3~75 parts of dried orange peel, 5~150 parts of the root of Dahurain angelica, 2~55 parts of radix polygonati officinalis, 3~75 parts of mulberry leaf.
2. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 2, which is characterized in that the raw material by weighing as follows
Measure the component composition of part：15~400 parts of honeysuckle, 10~200 parts of Radix Glycyrrhizae, 5~100 parts of the sterculia seed, 3~60 parts of dried orange peel, the root of Dahurain angelica 5
~100 parts, 2~50 parts of radix polygonati officinalis, 3~60 parts of mulberry leaf.
3. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 1 or 2, which is characterized in that each in the raw material
Extract powder is made in component in a manner of extraction, and preparation method is as follows：The raw material components of recipe quantity are taken, extracting in water n times merge
The extracting solution extracted every time, filter, be concentrated under reduced pressure, be spray-dried to get.
4. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 3, which is characterized in that the raw material extract powder carries
In taking technique, times N >=2 of extraction, extraction time is 1~4 hour.
5. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 3, which is characterized in that the raw material extract powder carries
In taking technique, Extraction solvent is selected from one or more of water, ethyl alcohol, chloroform, acetone, ethyl acetate, methanol.
6. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 3, which is characterized in that each raw material medicinal extract
Powder is made respectively by following extracting method：
1) honeysuckle：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the quantity of solvent added by first time extracting in water was medicinal material
6~30 times of amount of weight, the solvent added for the second time are 5~25 times of medicinal material weight, merge extracting solution, filter, are concentrated under reduced pressure,
Spray drying, obtains honeysuckle concrete powder；
2) Radix Glycyrrhizae：It takes in right amount, adds extraction 2 times, 1~4 hour every time, for the first time plus the quantity of solvent added by extraction with aqueous solution was medicinal material
6~30 times of amount of weight, the solvent added for the second time are 6~25 times of medicinal material weight, merge extracting solution, filter, are concentrated under reduced pressure,
Spray drying, obtains Radix Glycyrrhizae extractum powder；
3) sterculia seed：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the water added by first time extracting in water was medicinal material weight
6~20 times of water of amount, the water added for the second time are 5~15 times of medicinal material weight, merge extracting solution, filter, be concentrated under reduced pressure,
Spray drying, obtains sterculia seed extract powder；
4) dried orange peel：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the quantity of solvent added by first time extracting in water was medicinal material weight
6~30 times of amount of amount, the solvent added for the second time are 5~25 times of medicinal material weight, merge extracting solution, filter, be concentrated under reduced pressure, spray
Mist is dried, and obtains dried orange peel extract powder；
5) root of Dahurain angelica：It takes in right amount, adds extraction 2 times, 1~4 hour every time, for the first time plus the quantity of solvent added by extraction with aqueous solution was medicinal material
6~30 times of amount of weight, the solvent added for the second time are 6~25 times of medicinal material weight, merge extracting solution, filter, are concentrated under reduced pressure,
Spray drying, obtains root of Dahurain angelica extract powder；
6) radix polygonati officinalis：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the water added by first time extracting in water was medicinal material weight
6~20 times of water, second plus water be 5~15 times of medicinal material weight, merge extracting solution, filtration is concentrated under reduced pressure, spray
Mist is dried, and obtains radix polygonati officinalis extract powder；
7) mulberry leaf：It takes in right amount, extracting in water 2 times, 1~4 hour every time, the water added by first time extracting in water was medicinal material weight
6~20 times of water, second plus water be 5~15 times of medicinal material weight, merge extracting solution, filtration is concentrated under reduced pressure, spray
Mist is dried, and obtains mulberry extract powder.
7. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 1 or 2, which is characterized in that described pharmaceutically may be used
The auxiliary material of receiving is made of corrigent, binder and lubricant, and wherein corrigent is white granulated sugar, PEARLITOL 25C sugar, citric acid, indigo plant
One or more of certain kind of berries dried fruit juice, strawberry fruit juice powder, kumquat juice powder, peppermint oil；Binder is maltodextrin, starch, bright
One kind in glue, sodium carboxymethylcellulose, hydroxypropyl cellulose, methylcellulose, ethyl cellulose, hydroxypropyl methyl cellulose
It is or several；Lubricant is one or more of magnesium stearate, superfine silica gel powder, talcum powder and silica.
8. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 7, which is characterized in that described is pharmaceutically acceptable
Auxiliary material be made of corrigent, binder and lubricant, wherein corrigent for white granulated sugar, PEARLITOL 25C sugar, juice of Fructus vaccini vitis-idaeae powder, lemon
Lemon acid and peppermint oil, binder are maltodextrin, and lubricant is magnesium stearate.
9. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 8, which is characterized in that described is pharmaceutically acceptable
Auxiliary material, be made of following components by weight：35~400 parts of white granulated sugar, PEARLITOL 25C sugar are 20~350 parts, malt
Dextrin is 10~150 parts, and magnesium stearate is 10~162 parts, 10~50 parts of juice of Fructus vaccini vitis-idaeae powder, 5~40 parts of citric acid, peppermint oil 5
~10 parts.
10. the compound Chinese medicinal preparation of pharynx-clearing throat-benefiting according to claim 1, which is characterized in that the raw material is by as follows
The component composition of parts by weight：120 parts of honeysuckle, 60 parts of Radix Glycyrrhizae, 30 parts of the sterculia seed, 15 parts of dried orange peel, 12 parts of the root of Dahurain angelica, 8 parts of radix polygonati officinalis, mulberry
12 parts of leaf；The auxiliary material is made of the component of following parts by weight：335 parts of white granulated sugar, PEARLITOL 25C sugar are 220 parts, malt paste
Essence is 143 parts, and magnesium stearate is 150 parts, 50 parts of juice of Fructus vaccini vitis-idaeae powder, 40 parts of citric acid, 5 parts of peppermint oil.
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| CN117731737A (en) * | 2024-02-19 | 2024-03-22 | 云南红青夫生物科技股份有限公司 | Throat-clearing and-wetting lozenge |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060002147A (en) * | 2004-07-01 | 2006-01-09 | 이재준 | Food composition which is effective for oral and throat disease, manufacturing method thereof |
| CN101721614A (en) * | 2009-11-06 | 2010-06-09 | 吉林敖东延边药业股份有限公司 | Pharmaceutical composition with effects of clearing throat, reducing swelling and alleviating pain |
| CN102784218A (en) * | 2012-08-19 | 2012-11-21 | 王子英 | Traditional Chinese medicine preparation for treating sphagitis |
| CN104784586A (en) * | 2015-04-30 | 2015-07-22 | 杭州索契科技有限公司 | Traditional Chinese medicinal composition with throat clearing, lung moistening and fire clearing effects |
| CN105726920A (en) * | 2016-04-06 | 2016-07-06 | 杭州环特生物科技股份有限公司 | Anti-PM2.5 chewable tablets and preparing method thereof |
-
2016
- 2016-12-29 CN CN201611249172.8A patent/CN108244642A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060002147A (en) * | 2004-07-01 | 2006-01-09 | 이재준 | Food composition which is effective for oral and throat disease, manufacturing method thereof |
| CN101721614A (en) * | 2009-11-06 | 2010-06-09 | 吉林敖东延边药业股份有限公司 | Pharmaceutical composition with effects of clearing throat, reducing swelling and alleviating pain |
| CN102784218A (en) * | 2012-08-19 | 2012-11-21 | 王子英 | Traditional Chinese medicine preparation for treating sphagitis |
| CN104784586A (en) * | 2015-04-30 | 2015-07-22 | 杭州索契科技有限公司 | Traditional Chinese medicinal composition with throat clearing, lung moistening and fire clearing effects |
| CN105726920A (en) * | 2016-04-06 | 2016-07-06 | 杭州环特生物科技股份有限公司 | Anti-PM2.5 chewable tablets and preparing method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117731737A (en) * | 2024-02-19 | 2024-03-22 | 云南红青夫生物科技股份有限公司 | Throat-clearing and-wetting lozenge |
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