CN108524719A - A kind of Chinese medicine composition and preparation method thereof for treating tumour - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating tumour Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/748—Oldenlandia or Hedyotis
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention belongs to technical field of traditional Chinese medicines, a kind of Chinese medicine composition for treating tumour is mainly prepared from the following raw materials in parts by weight：27~87 parts of 9~45 parts of mock-strawberry, 9~45 parts of earthworm, 10~41 parts of solanum lyratum, 16~49 parts of oldenlandia diffusa, 16~49 parts of Sculellaria barbata, 16~49 parts of hairy grape stem, 13~38 parts of sargentodoxa cuneata, 5~31 parts of seaweed, 0.5~5 part of the dried venom of toads, 6~29 parts of tortoiseshell, 14~39 parts of pangolin, 3~34 parts of Dysosma versipellis, 4~27 parts of yellow ginger, 8~36 parts of edible tulip and Chinese yew.Preparation method is：Other raw materials in addition to the dried venom of toads are crushed, and heating and refluxing extraction is carried out using ethyl acetate, obtain the dregs of a decoction and extracting solution, extracting solution vacuum rotating is drained, and concentrate is obtained；The dregs of a decoction, which boil, to be carried, and Aqueous extracts are obtained；Concentrate is merged with Aqueous extracts, be condensed into relative density be 1.1~1.2 clear creams, then by the dried venom of toads be added clear cream in, mixing to get.The Chinese medicine composition of the present invention has the function of good treatment tumour, improves therapeutic effect.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, a kind of Chinese medicine composition and preparation method thereof for treating tumour.
Background technology
Tumour (tumour) refers to body under the effect of the various tumorigenesis factors, and local organization hyperplasia is formed by new life
Object (neogrowth), because this neoformation is in occupancy block-like protrusions, also referred to as neoplasm (neoplasm) more.According to new life
The cell characteristics of object and harmfulness degree to body, and tumour is divided into benign tumour and malignant tumour two major classes, and cancer
The as general name of malignant tumour.Tumour be seriously threaten one of the major disease of people's life security at present, no matter both at home and abroad, often
The a large amount of patients of Nian Douyou dead western medical treatment due to suffering from tumour includes mainly operative treatment, radiotherapy and chemotherapy at present, these three
Method it is different degrees of extend the life span of tumour patient, but all have that side effect is big, the halfway drawback for the treatment of,
Either operation, radiotherapy or chemotherapy, the injury to human normal tissue are to be also apparent, and can all increase the pain of patient,
And it can not thoroughly cure tumour.
Application publication number is CN107812148A, and data of publication of application is the Chinese invention patent on March 20th, 2018, open
A kind of Chinese medicine that treating tumour, is prepared from the following components：Road Radix Codonopsis, Radix Astragali, Chinese Magnoliavine, northern matrimony vine, the tuber of dwarf lilyturf, white Fu
Siberian cocklebur, GUANG Radix Notoginseng, radix rehmanniae preparata, edible tulip, Bulbus Fritillariae Thunbergii, kelp, seaweed, stir-baked RHIZOMA SPARGANII with vinegar, stir-baked RHIIZOMA CURCUMAE with vinegar, dandelion, preparation method are：According to upper
Weight meter is stated, all traditional Chinese medicinal components dosages are mixed, are smashed, 40 mesh sieve is crossed, then presses 1:1 weight ratio with
Practice honey and honeyed bolus is made.
Authorization Notice No. is CN103356973B, and the Chinese invention patent that authorized announcement date is on 2 25th, 2015 is open
A kind of antitumor Chinese medicine, including Radix Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Sculellaria barbata, oldenlandia diffusa, Rhizoma Atractylodis Macrocephalae, the membrane of a chicken's gizzard, pig
The medicinal materials such as Siberian cocklebur, mock-strawberry, radix ranunculi ternati, Radix Curcumae, honey-fried licorice root, scorpio, the dried venom of toads, each group medicine complement each other, and have both helped the uptake and transport of drug,
Prevent that all medicines is sweet stagnant cool cold again, can help spleen and lung gas, invigorating spleen to remove dampness, dissolving phlegm softening hard masses break dissipating bind gas, and the present invention both can be independent
It using treatment tumour, can also simultaneously be used with operation, radiotherapy, chemotherapy, its main feature is that quick, curative effect is reliable, without apparent
Toxic side effect.
The Chinese medicine of the treatment tumour of above-mentioned patent disclosure, there is a certain curative effect, but its effect is unsatisfactory.
Invention content
One aspect of the present invention technical problems to be solved are to provide a kind of Chinese medicine composition for treating tumour, swollen to improve
The therapeutic effect of tumor.
In order to solve the above-mentioned technical problem, the technical scheme is that：
A kind of Chinese medicine composition for treating tumour, is mainly prepared from the following raw materials in parts by weight：9~45 parts of mock-strawberry is worn
9~45 parts of earthworm, 10~41 parts of solanum lyratum, 16~49 parts of oldenlandia diffusa, 16~49 parts of Sculellaria barbata, hairy grape stem 16~49
Part, 13~38 parts of sargentodoxa cuneata, 5~31 parts of seaweed, 0.5~5 part of the dried venom of toads, 6~29 parts of tortoiseshell, 14~39 parts of pangolin, Dysosma versipellis 3
27~87 parts of~34 parts, 4~27 parts of yellow ginger, 8~36 parts of edible tulip and Chinese yew.
In the Chinese medicine composition for the treatment of tumour provided by the invention, it is preferable that mainly by the raw material of following parts by weight
It is made：9~45 parts of mock-strawberry, 9~45 parts of earthworm, 10~41 parts of solanum lyratum, 16~49 parts of oldenlandia diffusa, Sculellaria barbata 16~49
Part, 13~38 parts of sargentodoxa cuneata, 5~31 parts of seaweed, 0.5~5 part of the dried venom of toads, 6~29 parts of tortoiseshell, wears mountain at 16~49 parts of hairy grape stem
27~87 parts of 14~39 parts of first, 3~34 parts of Dysosma versipellis, 4~27 parts of yellow ginger, 8~36 parts of edible tulip and Chinese yew.
In the Chinese medicine composition for the treatment of tumour provided by the invention, it is preferable that mainly by the raw material of following parts by weight
It is made：It is 25 parts of mock-strawberry, 25 parts of earthworm, 20 parts of solanum lyratum, 30 parts of oldenlandia diffusa, 30 parts of Sculellaria barbata, 30 parts of hairy grape stem, big
20 parts of blood rattan, 15 parts of seaweed, 2 parts of the dried venom of toads, 15 parts of tortoiseshell, 30 parts of pangolin, 10 parts of Dysosma versipellis, 15 parts of yellow ginger, 15 parts of edible tulip
With 47 parts of Chinese yew.
The technical issues of being solved described in another aspect of the present invention is to provide a kind of preparation of Chinese medicine composition that treating tumour
Method includes the following steps：
S1, each raw material is weighed by weight ratio, by mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, bryony
Rattan, sargentodoxa cuneata, seaweed, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and taxus chinensis powder are broken to 50~80 mesh；
S2, the mock-strawberry by after crushing, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, sargentodoxa cuneata, sea
In algae, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew input refluxing extraction tank, then add into refluxing extraction tank
Enter ethyl acetate, the weight ratio of the raw material and the ethyl acetate is 1:5~8, heating and refluxing extraction 3~7 hours；The dregs of a decoction and
Extracting solution vacuum rotating is drained, obtains concentrate by extracting solution；
S3, dregs of a decoction input obtained by step S2 is boiled carry in tank again, then water is added in tank to boiling to carry, the dregs of a decoction and the water
Weight ratio be 1:4~9, it boils and carries 3~6 hours, obtain Aqueous extracts；
S4, concentrate is merged with Aqueous extracts, it is 1.1~1.2 clear creams to be condensed into relative density, then clear cream is added in the dried venom of toads
In, mixing to get.
In the preparation method of the Chinese medicine composition for the treatment of tumour provided by the invention, it is preferable that the raw material and acetic acid
The weight ratio of ethyl ester is 1:5.
In the preparation method of the Chinese medicine composition for the treatment of tumour provided by the invention, it is preferable that described be heated to reflux carries
It is 5 hours to take the time.
It is provided by the invention treatment tumour Chinese medicine composition preparation method in, it is preferable that the dregs of a decoction with it is described
The weight ratio of water is 1:6.
It is provided by the invention treatment tumour Chinese medicine composition preparation method in, it is preferable that it is described boil carry the time be 5
Hour.
Mock-strawberry, the rose family, the complete stool of perennial herb mock-strawberry Duchesnea indica (Andr.) Focke.It is sweet, bitter；
It is cold.Return lung；Liver；Large intestine channel.Heat-clearing, cool blood are subsided a swelling, removing toxic substances.Pyreticosis is controlled, frightened epilepsy is coughed, and is spitted blood, abscess of throat, dysentery, carbuncle
It is swollen, furunculosis, snakebite and bugbite, burn.
Earthworm, Dioscoreaceae dioscorea hollyhock-like yam rhizome Dioscorea althaeoides R.Knuth, with root shape
Stem is used as medicine.Autumn acquires, and dries.Hardship is put down.Relaxing tendons and activating collaterals, dispelling wind and eliminating dampness.For rheumatic numbness, traumatic injury, having indigestion is glutted,
Indigestion.
Solanum lyratum, the complete stool for being for Aristolochiaceae, birthwort solanum lyratum Solanum lyratum Thunb..Property
Flat, bitter has wind-damp dispelling, the function of degrading the channel and analgesic, treatment stomachache, muscle and bone ache.
Oldenlandia diffusa is Rubiaceae plants of Hedyotis oldenlandia diffusa Hedyotis diffusa Willd.
The herb of [Oldenlandia diffusa (Willd.) Roxb.].Summer and autumn acquire, and clean, fresh or dried.It is stomach, large intestine, small
Intestines pass through.Clearing heat and detoxicating, dampness removing is treating stranguria.
Sculellaria barbata, this product are the drying herb of labiate Sculellaria barbata Scutellaria barbata D.Don.Summer,
Two season of autumn cauline leaf it is luxuriant when excavate, clean, dry.It is pungent, bitter, it trembles with fear.Return lung, liver and kidney channel.It is clearing heat and detoxicating, change tinea diuresis.For malignant boil
Pyogenic infections from tumour or sore, abscess of throat, the pain of injury caused by falling and tumbling, oedema, jaundice, snakebite and bugbite.
Hairy grape stem is dicotyledon medicine vitaceae downy grape Vitis uinquangularis Rehd. complete stools
And leaf.It is sweet, flat.Heat-clearing, hemostasis.Control rheumatism, measles.Dysentery, dysentery, sore swollen toxin.
Sargentodoxa cuneata, this product are plants of Lardizabalaceae sargentodoxa cuneata Sargentodoxa cuneata (Oliw.) Rehd.et Wils.
Drying rattan.Autumn, the harvesting of two season of winter, remove side shoot, and intercept is dry.Hardship is put down.Return large intestine, Liver Channel.Cheongju thermal detoxifications, promoting blood circulation,
Wind-expelling pain-stopping.For abdominalgia with intestinal abscess, pathopyretic ulcer, Amenorrhea, dysmenorrhoea, tumbling and swelling, arthralgia pain due to rheumatism.
Seaweed, this product are Sargassaceae plant Sargassum Sargassum pallidum (Turn.) C.Ag. or sargassum fusifome
The drying frond of Sargassum fusiforme (Harv.) Setch..The former practises title " compatibile ", and the latter, which practises, claims " leaflet sea
Algae ".Summer, two season of autumn fish, and remove impurity, clean, dry.It is bitter, salty, it trembles with fear.Return liver, stomach, kidney channel.Dissolving phlegm softening and resolving hard mass, Li Shui
Detumescence.Yong Yu Gall tumors, scrofula, testiclar gall, phlegm and retained fluid oedema.
The dried venom of toads, this product are Bufonidae animal bufo gargarizans Cantor Bufo bufo gargarizans Cantor or Bufo melanostictus
The drying secretion of Bufo melanostictus Schneider.Toad is captured more than summer, two season of autumn, cleans, squeezes after taking ear
The white slurries of gland and glandula integumentaria are processed, dry.It is acrid in flavour and warm in nature；It is toxic.Thoughts of returning home warp.Removing toxic substances, analgesic, inducing resuscitation of having one's ideas straightened out.For ulcer
Furunculosis, abscess of throat, heatstroke coma, erputive abdominal disease are vomited and diarrhoea.
Tortoiseshell is the plastron and carapace of Testudinidae animal chinemys reevesii.
Pangolin, this product are Manidae animal pangolin Manis pentadactyla Linnaeus Scales first.Collect squama
First is cleaned, is dried.It is salty, it is slightly cold.Return liver, stomach.Activating blood to eliminate diseases, newborn under promoting menstruation, detumescence and apocenosis searches wind and removing obstruction in channels.For Jing Bi Disorder
Lump in the abdomen, alactation, carbuncle sore tumefacting virus, arthralgia pain due to rheumatism, paralysis due to windstroke, numbness contracture.
Dysosma versipellis is Berberidaceae, Podophyllum emodi var chinense category herbaceos perennial Dysosma versipellis Dysosma versipellis (Hance)
M.Cheng ex Ying.Bitter；It is pungent；It is cool in nature；It is toxic.Lung；Liver Channel.Reducing phlegm and resolving masses；Stasis-dispelling and pain-killing；It is clearing heat and detoxicating.Main cough；
Abscess of throat；Scrofula；Goiter and tumor；Carbuncle swells；Furunculosis；Venomous snake bite；Bruise harm；Bi Zheng.
Yellow ginger is the root of Dioscoreaceae dioscorea dioscorea zingiberensis wright Dioscorea Zingiberensis C.H.Wright
Stem.Spring and autumn excavates, and removes soil, dries.Sweet, bitter, cold.Removing toxicity for detumescence.For carbuncle furuncle early stage non-ulceration, skin acute festering type
Infection, soft tissue injury, bee sting insect bite.
Edible tulip, this product are orchid Cremastra appendiculata Gremastra appediculata (D.Don) Makino, pleione bulbocodioides
Pleione bulbocodioides (Franch.) Rolfe's or Pleione yunnanensis pleione yunnanensis Rolfe is dry
Dry vacation squama lotus.The former practises title " hair arrowhead ", the latter two, which are practised, claims " pleionebulbocodioides rolfe ".Summer, the excavation of two season of autumn, remove aerial part and mud
Sand, it is dry to the saturating heart that separated size sets boiling in boiling water pot.Sweet, micro-pungent, it is cool.Return liver, the spleen channel.It is clearing heat and detoxicating, reducing phlegm and resolving masses.
For carbuncle swells serious case of furuncle, scrofula subcutaneous nodule, snakebite and bugbite, abnormal pigmentary deposit on the skin lump in the abdomen lump in the abdomen.
Chinese yew, this product are the drying branch of taxaceae plant yew Taxus chinensis (Pilger) Rehd.
Leaf.
Using above-mentioned technical proposal, due to mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, big
Blood rattan, seaweed, the dried venom of toads, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew reasonable compatibility so that it is of the invention
Chinese medicine composition has the function of that good treatment tumour, treatment total effective rate reach 85% or more, improve the treatment of tumour
Effect.Sargentodoxa cuneata and solanum lyratum have synergistic function to the total effective rate for improving oncotherapy in this bright compatibility.
Specific implementation mode
The specific implementation mode of the present invention is described further below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but does not constitute limitation of the invention.In addition, invention described below
Involved technical characteristic can be combined with each other as long as they do not conflict with each other in each embodiment.
Embodiment 1
A kind of Chinese medicine composition for treating tumour is present embodiments provided, is mainly prepared from the following raw materials in parts by weight：
45 parts of mock-strawberry, 9 parts of earthworm, 41 parts of solanum lyratum, 16 parts of oldenlandia diffusa, 16 parts of Sculellaria barbata, 16 parts of hairy grape stem, sargentodoxa cuneata 38
Part, 5 parts of seaweed, 5 parts of the dried venom of toads, 6 parts of tortoiseshell, 14 parts of pangolin, 34 parts of Dysosma versipellis, 27 parts of yellow ginger, 8 parts of edible tulip and Chinese yew 87
Part.
The preparation method of the Chinese medicine composition of the treatment tumour, includes the following steps：
S1, each raw material is weighed by weight ratio, by mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, bryony
Rattan, sargentodoxa cuneata, seaweed, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and taxus chinensis powder are broken to 80 mesh；
S2, the mock-strawberry by after crushing, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, sargentodoxa cuneata, sea
In algae, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew input refluxing extraction tank, then add into refluxing extraction tank
Enter ethyl acetate, the weight ratio of the raw material and the ethyl acetate is 1:5, heating and refluxing extraction 7 hours；The dregs of a decoction and extraction
Extracting solution vacuum rotating is drained, obtains concentrate by liquid；
S3, dregs of a decoction input obtained by step S2 is boiled carry in tank again, then water is added in tank to boiling to carry, the dregs of a decoction and the water
Weight ratio be 1:9, it boils and carries 3 hours, obtain Aqueous extracts；
S4, concentrate is merged with Aqueous extracts, it is 1.1 clear creams to be condensed into relative density, then the dried venom of toads is added in clear cream, is mixed
It is even to get.
Embodiment 2
A kind of Chinese medicine composition for treating tumour is present embodiments provided, is mainly prepared from the following raw materials in parts by weight：
9 parts of mock-strawberry, 45 parts of earthworm, 10 parts of solanum lyratum, 49 parts of oldenlandia diffusa, 49 parts of Sculellaria barbata, 49 parts of hairy grape stem, sargentodoxa cuneata 13
Part, 31 parts of seaweed, 0.5 part of the dried venom of toads, 29 parts of tortoiseshell, 39 parts of pangolin, 3 parts of Dysosma versipellis, 4 parts of yellow ginger, 36 parts of edible tulip and red bean
27 parts of China fir.
The preparation method of the Chinese medicine composition of the treatment tumour, includes the following steps：
S1, each raw material is weighed by weight ratio, by mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, bryony
Rattan, sargentodoxa cuneata, seaweed, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and taxus chinensis powder are broken to 50 mesh；
S2, the mock-strawberry by after crushing, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, sargentodoxa cuneata, sea
In algae, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew input refluxing extraction tank, then add into refluxing extraction tank
Enter ethyl acetate, the weight ratio of the raw material and the ethyl acetate is 1:8, heating and refluxing extraction 3 hours；The dregs of a decoction and extraction
Extracting solution vacuum rotating is drained, obtains concentrate by liquid；
S3, dregs of a decoction input obtained by step S2 is boiled carry in tank again, then water is added in tank to boiling to carry, the dregs of a decoction and the water
Weight ratio be 1:4, it boils and carries 6 hours, obtain Aqueous extracts；
S4, concentrate is merged with Aqueous extracts, it is 1.2 clear creams to be condensed into relative density, then the dried venom of toads is added in clear cream, is mixed
It is even to get.
Embodiment 3
A kind of Chinese medicine composition for treating tumour is present embodiments provided, is mainly prepared from the following raw materials in parts by weight：
25 parts of mock-strawberry, 25 parts of earthworm, 20 parts of solanum lyratum, 30 parts of oldenlandia diffusa, 30 parts of Sculellaria barbata, 30 parts of hairy grape stem, sargentodoxa cuneata
20 parts, 15 parts of seaweed, 2 parts of the dried venom of toads, 15 parts of tortoiseshell, 30 parts of pangolin, 10 parts of Dysosma versipellis, 15 parts of yellow ginger, 15 parts of edible tulip and red
47 parts of beans China fir.
The preparation method of the Chinese medicine composition of the treatment tumour, includes the following steps：
S1, each raw material is weighed by weight ratio, by mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, bryony
Rattan, sargentodoxa cuneata, seaweed, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and taxus chinensis powder are broken to 60 mesh；
S2, the mock-strawberry by after crushing, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, sargentodoxa cuneata, sea
In algae, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew input refluxing extraction tank, then add into refluxing extraction tank
Enter ethyl acetate, the weight ratio of the raw material and the ethyl acetate is 1:5, heating and refluxing extraction 5 hours；The dregs of a decoction and extraction
Extracting solution vacuum rotating is drained, obtains concentrate by liquid；
S3, dregs of a decoction input obtained by step S2 is boiled carry in tank again, then water is added in tank to boiling to carry, the dregs of a decoction and the water
Weight ratio be 1:6, it boils and carries 5 hours, obtain Aqueous extracts；
S4, concentrate is merged with Aqueous extracts, it is 1.2 clear creams to be condensed into relative density, then the dried venom of toads is added in clear cream, is mixed
It is even to get.
Embodiment 4
A kind of Chinese medicine composition for treating tumour is present embodiments provided, is mainly prepared from the following raw materials in parts by weight：
34 parts of mock-strawberry, 25 parts of earthworm, 37 parts of solanum lyratum, 20 parts of oldenlandia diffusa, 21 parts of Sculellaria barbata, 36 parts of hairy grape stem, seaweed 27
31 parts of part, 3 parts of the dried venom of toads, 15 parts of tortoiseshell, 23 parts of pangolin, 24 parts of Dysosma versipellis, 16 parts of yellow ginger, 11 parts of edible tulip and Chinese yew.
The preparation method of the Chinese medicine composition of the treatment tumour, includes the following steps：
S1, each raw material is weighed by weight ratio, by mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, bryony
Rattan, sargentodoxa cuneata, seaweed, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and taxus chinensis powder are broken to 70 mesh；
S2, the mock-strawberry by after crushing, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, sargentodoxa cuneata, sea
In algae, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew input refluxing extraction tank, then add into refluxing extraction tank
Enter ethyl acetate, the weight ratio of the raw material and the ethyl acetate is 1:7, heating and refluxing extraction 4 hours；The dregs of a decoction and extraction
Extracting solution vacuum rotating is drained, obtains concentrate by liquid；
S3, dregs of a decoction input obtained by step S2 is boiled carry in tank again, then water is added in tank to boiling to carry, the dregs of a decoction and the water
Weight ratio be 1:8, it boils and carries 4 hours, obtain Aqueous extracts；
S4, concentrate is merged with Aqueous extracts, it is 1.2 clear creams to be condensed into relative density, then the dried venom of toads is added in clear cream, is mixed
It is even to get.
Embodiment 5
A kind of Chinese medicine composition for treating tumour is present embodiments provided, is mainly prepared from the following raw materials in parts by weight：
28 parts of mock-strawberry, 37 parts of earthworm, 38 parts of oldenlandia diffusa, 21 parts of Sculellaria barbata, 46 parts of hairy grape stem, 24 parts of sargentodoxa cuneata, seaweed 11
49 parts of part, 1 part of the dried venom of toads, 15 parts of tortoiseshell, 27 parts of pangolin, 24 parts of Dysosma versipellis, 13 parts of yellow ginger, 12 parts of edible tulip and Chinese yew.
The preparation method of the Chinese medicine composition of the treatment tumour, includes the following steps：
S1, each raw material is weighed by weight ratio, by mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, bryony
Rattan, sargentodoxa cuneata, seaweed, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and taxus chinensis powder are broken to 60 mesh；
S2, the mock-strawberry by after crushing, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, sargentodoxa cuneata, sea
In algae, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew input refluxing extraction tank, then add into refluxing extraction tank
Enter ethyl acetate, the weight ratio of the raw material and the ethyl acetate is 1:6, heating and refluxing extraction 6 hours；The dregs of a decoction and extraction
Extracting solution vacuum rotating is drained, obtains concentrate by liquid；
S3, dregs of a decoction input obtained by step S2 is boiled carry in tank again, then water is added in tank to boiling to carry, the dregs of a decoction and the water
Weight ratio be 1:7, it boils and carries 5 hours, obtain Aqueous extracts；
S4, concentrate is merged with Aqueous extracts, it is 1.1 clear creams to be condensed into relative density, then the dried venom of toads is added in clear cream, is mixed
It is even to get.
Test example
General information：It accepts tumor patient 300 for medical treatment altogether, is randomly divided into 5 groups, respectively 1 group of embodiment, 2 groups of embodiment, reality
Apply 5 groups of 3 groups of example, 4 groups of embodiment and embodiment.The general information such as gender, age, the drug resistance situation of each group patient compare without apparent
Otherness (P>0.05) it, is comparable.
Therapy：5 groups of 1 group of embodiment, 2 groups of embodiment, 3 groups of embodiment, 4 groups of embodiment and embodiment take reality respectively
The drug obtained by example 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 is applied, three times a day, each 10g one month is
One course for the treatment of.
Curative effect judging standard：
It is effective：Cancer cell is reduced, and immunity improves, energetic, painless；
Effectively：Cancer cell is substantially achieved inhibition, and immunity increases, spiritual not good enough, pain relief；
In vain：Cancer cell is constant, and mental status is poor, still has pain, symptom apparent.
Treatment results：As a result treatment through 3 courses for the treatment of is counted and be see the table below：
As can be seen from the above table, the treatment total effective rate of 1 to 3 group of embodiment is significantly higher than 4 groups of embodiment and embodiment 5
Group.In example 4, raw material reduces sargentodoxa cuneata in Chinese medicine composition；In embodiment 5, raw material is reduced in Chinese medicine composition
Solanum lyratum；As it can be seen that sargentodoxa cuneata and solanum lyratum have synergistic function to the total effective rate for improving oncotherapy.
Embodiments of the present invention are explained in detail above, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (8)
1. a kind of Chinese medicine composition for treating tumour, which is characterized in that be mainly prepared from the following raw materials in parts by weight：Mock-strawberry 9
~45 parts, 9~45 parts of earthworm, 10~41 parts of solanum lyratum, 16~49 parts of oldenlandia diffusa, 16~49 parts of Sculellaria barbata, bryony
16~49 parts of rattan, 13~38 parts of sargentodoxa cuneata, 5~31 parts of seaweed, 0.5~5 part of the dried venom of toads, 6~29 parts of tortoiseshell, pangolin 14~39
27~87 parts of part, 3~34 parts of Dysosma versipellis, 4~27 parts of yellow ginger, 8~36 parts of edible tulip and Chinese yew.
2. the Chinese medicine composition for the treatment of tumour according to claim 1, which is characterized in that mainly by following parts by weight
Raw material is made：9~45 parts of mock-strawberry, 9~45 parts of earthworm, 10~41 parts of solanum lyratum, 16~49 parts of oldenlandia diffusa, Sculellaria barbata 16
~49 parts, 16~49 parts of hairy grape stem, 13~38 parts of sargentodoxa cuneata, 5~31 parts of seaweed, 0.5~5 part of the dried venom of toads, 6~29 parts of tortoiseshell,
27~87 parts of 14~39 parts of pangolin, 3~34 parts of Dysosma versipellis, 4~27 parts of yellow ginger, 8~36 parts of edible tulip and Chinese yew.
3. the Chinese medicine composition for the treatment of tumour according to claim 2, which is characterized in that mainly by following parts by weight
Raw material is made：25 parts of mock-strawberry, 25 parts of earthworm, 20 parts of solanum lyratum, 30 parts of oldenlandia diffusa, 30 parts of Sculellaria barbata, hairy grape stem 30
Part, 20 parts of sargentodoxa cuneata, 15 parts of seaweed, 2 parts of the dried venom of toads, 15 parts of tortoiseshell, 30 parts of pangolin, 10 parts of Dysosma versipellis, 15 parts of yellow ginger, edible tulip
15 parts and 47 parts of Chinese yew.
4. treating the preparation method of the Chinese medicine composition of tumour according to claims 1 to 3 any one of them, which is characterized in that
Include the following steps：
S1, weigh each raw material by weight ratio, by mock-strawberry, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem,
Sargentodoxa cuneata, seaweed, tortoiseshell, pangolin, Dysosma versipellis, yellow ginger, edible tulip and taxus chinensis powder are broken to 50~80 mesh；
S2, the mock-strawberry by after crushing, earthworm, solanum lyratum, oldenlandia diffusa, Sculellaria barbata, hairy grape stem, sargentodoxa cuneata, seaweed, tortoise
In plate, pangolin, Dysosma versipellis, yellow ginger, edible tulip and Chinese yew input refluxing extraction tank, then acetic acid is added into refluxing extraction tank
The weight ratio of ethyl ester, the raw material and the ethyl acetate is 1:5~8, heating and refluxing extraction 3~7 hours；The dregs of a decoction and extraction
Extracting solution vacuum rotating is drained, obtains concentrate by liquid；
S3, dregs of a decoction input obtained by step S2 is boiled carry in tank again, then water is added in tank to boiling to carry, the weight of the dregs of a decoction and the water
Amount is than being 1:4~9, it boils and carries 3~6 hours, obtain Aqueous extracts；
S4, concentrate is merged with Aqueous extracts, it is 1.1~1.2 clear creams to be condensed into relative density, then the dried venom of toads is added in clear cream,
Mixing to get.
5. it is according to claim 4 treatment tumour Chinese medicine composition preparation method, which is characterized in that the raw material with
The weight ratio of ethyl acetate is 1:5.
6. the preparation method of the Chinese medicine composition for the treatment of tumour according to claim 4, which is characterized in that described to heat back
It is 5 hours to flow extraction time.
7. it is according to claim 4 treatment tumour Chinese medicine composition preparation method, which is characterized in that the dregs of a decoction with
The weight ratio of the water is 1:6.
8. the preparation method of the Chinese medicine composition for the treatment of tumour according to claim 4, which is characterized in that described to boil when carrying
Between be 5 hours.
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| CN103768110A (en) * | 2012-10-25 | 2014-05-07 | 寇彩琴 | Seaweed and tortoise plastron capsule |
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