CN108514117A - A kind of micro-capsule compound powder and its preparation process containing free from extraneous odour oils - Google Patents

A kind of micro-capsule compound powder and its preparation process containing free from extraneous odour oils Download PDF

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Publication number
CN108514117A
CN108514117A CN201810198524.4A CN201810198524A CN108514117A CN 108514117 A CN108514117 A CN 108514117A CN 201810198524 A CN201810198524 A CN 201810198524A CN 108514117 A CN108514117 A CN 108514117A
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water
soluble
oil
extractive
soluble extractive
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陈曼
寇爽
佘佐彦
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Beijing 3 Biological Technology Co Ltd
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Beijing 3 Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/03—Organic compounds
    • A23L29/035—Organic compounds containing oxygen as heteroatom
    • A23L29/04—Fatty acids or derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention relates to a kind of micro-capsule compound powder and its preparation process containing free from extraneous odour oil components, the present invention relates to food, medicine, field of health care products.Composition of the present invention contains oil phase, 10 180 parts by weight fat-soluble nutrients ingredients, 80 1000 parts by weight capsule materials and 10 100 parts by weight oil phase corrigents of 10 100 parts by weight without special odor.It is with good water solubility, human absorptivity is high, it is in good taste, take many advantages, such as mode is various.

Description

A kind of micro-capsule compound powder and its preparation process containing free from extraneous odour oils
Technical field
The present invention relates to food, medicine, field of health care products, in particular to a kind of containing whether there is or not the oil phases of special odor With the micro-capsule compound powder and its preparation process of fat-soluble nutrients ingredient.
Background technology
In food, drug, there is a kind of liposoluble substance itself not have bad smell, but when them and certain liposoluble Property nutritional ingredient combination when the taste that just will produce bad smell, taste bad, such as maize germ oil, soybean oil, wheat-germ oil, Sunflower oil, rice bran oil, Rice oil, grape seed oil, pungent certain herbaceous plants with big flowers acid glyceride and lutein, lutein ester, astaxanthin, five layers of dragon carry The fat-soluble nutrients ingredient such as object is taken to be combined.These fat-soluble compositions can prevent, treat a variety of diseases, be answered in food and medicine It is of far-reaching significance, but since they have undesirable aroma and flavor, poor compliance is taken orally, the daily method taken has Limit, makes troubles to patient.
In order to improve the bad smell of these fat-soluble compositions, capsule or microcapsule powder can be prepared into.It will be oily The form that class is prepared as soft capsule is swallowed for patient, avoids the problem of they have oily fishy smell and are difficult to swallow, but flexible glue The food oil poorly water-soluble of scrotiform formula, human body belongs to water environment, so being unfavorable for absorption of human body.It is prepared as water-dispersed Property good microcapsule powder, taking mode diversification and improving human absorptivity for drug can be made.Patent application CN104544092A《A kind of linseed oil microcapsule powder and its preparation process》Microcapsule powder is made in linseed oil, effectively embedding oil Fat, can cover the smell of drug, and improve their absorptivity.Although the product can reduce the bad smell of oils, So that product is smelt insipidness, but the taste of product can not be covered.Because this microcapsule powder is dispersed in water or nozzle Chew, this buccal microcapsule powder, can destroy microcapsule structure, expose the oil of poor taste, oil contacted with taste bud still have it is prodigious bad Taste.This kind of microcapsule powder product to take mode single, can only be swallowed in solid form, can not be chewed, it is buccal or It is dissolved in water to take, can not also be made into beverage and drink.Therefore, it is still necessary to further to have the formula of the oils of bad smell and Technique is improved, so as to prepare good water solubility, human absorptivity it is high, it is in good taste, take the various product of mode.
Invention content
The present invention is directed to the fat-soluble composition with bad smell, provides a kind of micro-capsule compound powder containing oils And its preparation process, the taste for improving this kind of composition and water solubility.Although soft gel products can improve taste, It is that soft capsule is insoluble in water, is unfavorable for product absorption, and take in the form of a single, can only take orally.In order to improve such food oil Water solubility, medicine preparation at microcapsule powder, not only improves solubility and absorption in the water of oils, increases drug effect by the present invention, and And mask bad smell.But microcapsule powder product in the prior art, smell can only be covered, taste cannot be covered, mouthfeel is not Have and reach ideal effect, requires further improvement formula and technique.And invent and provide a kind of microcapsule powder, it can both improve oil Solubility and absorption in the water of class increase drug effect, but also can mask bad smell and taste.
To achieve the goals above, the present invention provides a kind of micro-capsule compound powder containing oils, contains 10-100 Oil phase, 10-180 parts by weight fat-soluble nutrients ingredient, 80-1000 parts by weight capsule material and 10-100 weight of the parts by weight without special odor Measure part oil phase corrigent.
Preferably, the composition contains oil phase, 30-100 parts by weight fat-soluble nutrients of the 30-80 parts by weight without special odor Ingredient, 200-800 parts by weight capsule material and 30-80 parts by weight oil phase corrigents.
Preferably, the composition contains oil phase of 50 parts by weight without special odor, 50 parts by weight nutritional ingredients, 500 weight Part capsule material and 50 parts by weight oil phase corrigents.
Wherein, the oil phase of no special odor is selected from maize germ oil, soybean oil, wheat-germ oil, sunflower oil, rice bran Oil, Rice oil, grape seed oil, pungent certain herbaceous plants with big flowers acid glyceride, ethyl oleate, olive oil, Semen setariae oil, rapeseed oil, peanut oil, tea oil, palm fibre Palmitic acid oil, Canola oil, walnut oil, peony seed oil, safflower seed oil, cotton seed oil, coconut oil, apricot kernel oil, oleic acid, oleyl alcohol, octadecyl alcolol, 18 hexadecanols, atoleine, hydrogenated groundnut, hydrogenated cottonseed oil, glycerol monostearate acid esters, isopropyl myristate, second It is one or more in diacid monostearate, lanonol.
Preferably, fat-soluble nutrients ingredient be selected from OVIDUCTUS RANNAE, allicin, turmeric, curcumin, oryzanol, sensitiveplant-like senna seed phenol, Camellia seed extract, leukotrienes, linoleic acid, sheep placenta, lutein, lutein ester, fish oil, chromium picolinate, phosphatide, propolis, Gangliosides, astaxanthin, carrotene, vitamin A, heme iron, gynostemma pentaphylla, Radix salaciae prinoidis extract, can salad is uncommon, oyster, It is one or more in scurvy grass, milk thistle, basyleave, sulphur octanol.
Preferably, capsule material is selected from dextrin, agar, gelatin, Arabic gum, gelatine, fish glue, oligomeric maltose, caseinic acid Sodium, sodium alginate, fibrin, ethyl cellulose, nitrocellulose, carboxymethyl cellulose, cellulose acetate, hydroxypropyl methyl Cellulose, cellulose acetate phthalate, cellulose acetate butyl ester, cellulose acetate phthalate ester, polyethylene glycol, polychlorostyrene second It is one or more in alkene, polystyrene, poly- carbon ester, polyamide, polylactic acid, silica, modified starch.
Preferably, oil phase corrigent is selected from orange oil, oil of ginger, lemon oil, caryophyllus oil, cassia oil, sesame oil, castor-oil plant Oil, orange oil, cinnamon oil, eucalyptus oil, menthol, ennel oil, aniseed oil, cineol, ethyl acetate, wintergreen, octagonal fennel Sesame oil, patchouli oil, rosemary oil, thyme linaloe oil, litsea citrate oil, Oleum Citri Reticulatae, tea oil, nutmeg oil, garlic oil, folium artemisiae argyi Oil, citronella oil, geranium oil, lavender oil, rose oil, cnidium oil, catnip oil, citrus seed oil, levant storax oil, orange peel tincture, Fructus Forsythiae It is one or more in oil；Preferably, oil phase corrigent is selected from orange oil, oil of ginger, lemon oil, caryophyllus oil, fennel oil, cassia bark It is one or more in oily sesame oil, castor oil, orange oil, butter essence, butter.
Further, the composition also contains 1-50 parts by weight water phase corrigents.
Preferably, water phase corrigent is selected from acidic flavouring agent, sweetener, tasty agents, essence, natural fruit vegetable juice powder, rubber cement It is one or more in agent, fumet, dairy produce.
Preferably, acidic flavouring agent is one or more in vitamin C, malic acid, citric acid；Sweetener is selected from sugar It is smart sodium, stevioside, Aspartame, neotame, honey, Sucralose, honey element, Radix Glycyrrhizae, acesulfame potassium, A Shasufa, Tagatose, sweet It is one or more in oxalic acid disodium, glucose, fructose, sucrose, xylitol, simple syrup, fruit juice syrup；Tasty agents is selected from paddy ammonia One in sour sodium, asparatate, amion acetic acid, l-Alanine, disodium succinate, Sodium guanylate, inosine acid disodium, chickens' extract Kind is a variety of；Essence is selected from water-soluble natural essence, water-soluble compound essence, water-soluble natural and is equal to essence, water-soluble fermentation It is one or more in essence；Natural fruit vegetable juice powder is selected from lemon juice powder, mint juice powder, ginger juice powder, orange juice powder, pineapple juice Powder, water pear juice powder, watermelon juice powder, apple juice powder, Fresh Cucumber Juice powder, grape juice powder, kiwi-fruit juice powder, Passion Fruit Juice powder, strawberry juice Powder, mango juice powder, sugar-cane juice powder, Chinese flowering quince juice powder, asparagus juice powder, tomato juice powder, Celery Juice powder, spinach juice powder, carrot juice powder, It is one or more in pimento juice powder, green pepper juice powder；Mucilage be selected from sodium carboxymethylcellulose, methylcellulose, guar gum, Tragacanth, xanthans, Bletilla glucomannan, carbomer, polyvinyl alcohol, povidone, gelatin it is one or more；Fumet is selected from malt It is one or more in phenol, ethylmaltol, methyl cyclopentenyl ketone.
Further, the composition also contains 20-200 parts by weight water-soluble nutritional ingredients.
Preferably, water-soluble nutritional ingredient is selected from collagen, l-cn, vitamin C, barley element, calcium pantothenate, brown alga Glue, black tea polyphenols, inositol, carob, albumen peptide, hyaluronic acid, chondroitin sulfate, Cassia bean gum, L-arginine, Arab Glue, ferulic acid, γ-aminobutyric acid, Glucosamine, cysteine, galactomannan, L-thiamine, tea polyphenols, super oxygen Compound mutase, antierythrite, soybean protein, soybean oligopeptide, soyabean oligosaccharides, isoflavones, single glucose glycyrrhizic acid It is glycosides, Yolk immune globulin, galactooligosaccharide, galacturonic acid oligosaccharides, oligofructose, oligomeric synanthrin, oligomeric dragon gallbladder sugar, oligomeric Maltose, xylo-oligosaccharide, lactosucrose, oligosaccharide fiber, oligoisomaltose, reduced isomaltooligosaccharide, 1,6- diphosphonic acid Fructose, honey, beeswax, royal jelly, ferrous fumarate, glycine, mannitol, high F value oligopeptide, L-Glutamine, paddy Guang Sweet peptide, guar gum, guarana beans, alginic acid oligosaccharide, trehalose, nucleic acid, deodorized red cabbage color, active polysaccharide, blood pressure lowering peptide, Ferric pyrophosphate, inulin, polydextrose, cocoa polyphenol, L-lysine, casein phosphopeptide, casein calcium peptide, ferrous sulfate, sulphur Octanoic acid, zinc sulfate, chlorogenic acid, maltitol, enzyme modification rutin sophorin, magnesium gluconate, magnesium lactate, Kiwi extract, rice bran Hemicellulose, gossypose, xylitol, indigestible dextrins, condensation polysaccharide, taurine, Bilberry fruit P.E, coupling sugar, apple are more Phenol, vine polyphenol, wine polyphenols, calcium gluconate, manganese gluconate, zinc gluconate, ferrous gluconate, grape pip carry Take object, hydroxycitric acid, agar oligosaccharide, lysozyme, α-lactalbumin, emulsification ferric pyrophosphate, lactalbumin, calcium lactate, breast Sour bacterium, Pfansteihl zinc, ferrous lactate, lactitol, lactoferrin, chromium trichloride, sorbierite, edible mushroom fiber, l threonic acid, Bifidobacterium, stachyose, aspartic acid, calcium aspartate, vitamin B1, vitamin B2, vitamin B6, vitamin B12, oolong Tea extraction, sodium selenate, sodium selenite, zinc gluconate, niacinamide, oat bran, sodium iron ethylene diamine tetra acetate, calcium acetate, N- acetyl-Glucosamine, isomerizing lactose, isomaltoketose, hydroxyl isomaltulose, coriolan, cyanophycin, fat metabolism Adjust peptide, N- formyls tyrasamine, bamboo-leaves flavones, transgalactosidation oligosaccharide, pullulan, Radix Isatidis water-soluble extractive, peppermint Water-soluble extractive, Asiatic plantain water-soluble extractive, plantain seed water-soluble extractive, Rosa roxburghii Tratt water-soluble extractive, radix cyathulae water Soluble extract, Herba Andrographitis water-soluble extractive, barley seedling water-soluble extractive, Radix Angelicae Sinensis water-soluble extractive, Radix Codonopsis are water-soluble Extract, earthworm water-soluble extractive, cordyceps sinensis water-soluble extractive, Rabdosia rubescens water-soluble extractive, Cortex Eucommiae water solubility carry Take object, galangal water-soluble extractive, pueraria lobata water-soluble extractive, gekko water-soluble extractive, seaweed water-soluble extractive, red Red-spotted stonecrop water-soluble extractive, Bee Pollen water-soluble extractive, red ginseng water-soluble extractive, Hericium erinaceus water-soluble extractive, Cortex Magnoliae Officinalis Water-soluble extractive, sealwort water-soluble extractive, wrinkled giant hyssop water-soluble extractive, the membrane of a chicken's gizzard water-soluble extractive, ginger water solubility carry It takes object, balsam pear water-soluble extractive, blueberry water-soluble extractive, blue-green algae water-soluble extract, ganoderma lucidum water-soluble extractive, split pleat Bacterium water-soluble extractive, aloe water-soluble extractive, green tea water-soluble extractive, green alga water-soluble extractive, Folium Apocyni Veneti water Soluble extract, water-soluble spirulina extract, Siraitia grosvenorii water-soluble extractive, red deer bone water-soluble extractive, ant are water-soluble Property extract, tuber of dwarf lilyturf water-soluble extractive, rosemary water-soluble extractive, pawpaw water-soluble extractive, root of Aucklandia lappa Decne water solubility carry Take object, natto water-soluble extractive, the water-soluble extractive that makes vinegar, great burdock achene water-soluble extractive, the extraction of colostrum water solubility Object, root of bidentate achyranthes water-soluble extractive, sterculia seed water-soluble extractive, dandelion water-soluble extractive, cattail pollen water-soluble extractive, seven Leaf tree water-soluble extractive, buckwheat water-soluble extractive, ginseng water-soluble extract, Herba Cistanches water-soluble extractive, Pork and beans Cool water-soluble extractive, Chinese cassia tree water-soluble extractive, frankincense water-soluble extractive, Radix Notoginseng water-soluble extractive, the root bark of white mulberry are water-soluble Property extract, Ramulus Taxilli water-soluble extractive, Gymnema Sylvestre water-soluble extractive, enzyme modification Gymnema Sylvestre extract are water-soluble Property extract, sea-buckthorn water-soluble extractive, Shark cartilage water-soluble extractive, Chinese yam water-soluble extractive, Fructus Corni it is water-soluble Extract, cimicifugae foetidae water-soluble extractive, stem of noble dendrobium water-soluble extractive, edible fungus water-soluble extract, the extraction of vine of multiflower knotweed water solubility Object, Salvia japonica water-soluble extractive, Echinacea purpurea water-soluble extractive, Pine Bark water-soluble extractive, spina date seed are water-soluble Property extract, cynomorium songaricum water-soluble extractive, radix pseudostellariae water-soluble extractive, Rhizoma Gastrodiae water-soluble extractive, lucid asparagus water solubility carry Take object, Semen Cuscutae water-soluble extractive, Gallus domesticlus brisson water-soluble extractive, cortex acanthopanacis water-soluble extractive, the extraction of Schisandra chinensis water solubility Object, west safflower water-soluble extractive, American Ginseng water-soluble extractive, hairyvein agrimony water-soluble extractive, thizoma curculiginis water-soluble extractive, HERBA EPIMEDII water-soluble extractive, mushroom water-soluble extractive, valerian water-soluble extractive, saussurea involucrata water-soluble extractive, linseed Glue soluble extract, bird's nest water-soluble extractive, onion water-soluble extractive, wild chrysanthemum water-soluble extractive, motherwort water Soluble extract, fructus alpiniae oxyphyllae water-soluble extractive, Herba Epimedii water-soluble extractive, white fungus water-soluble extractive, ginkgo leaf are water-soluble Property extract, cordate houttuynia water-soluble extractive, basyleave water-soluble extractive, Antrodia camphorata water-soluble extractive, pearl it is water-soluble Extract, cape jasmine water-soluble extractive, Semen Hoveniae (Fructus Hoveniae) water-soluble extractive, dried immature fruit of citron orange water-soluble extractive, umbellate pore furgus water-soluble extractive, Asian puccoon water-soluble extractive, perilla seed water-soluble extractive, japanese angelica tree water-soluble extractive, golden ear water-soluble extractive, black soya bean Water-soluble extractive, safflower water-soluble extractive, centella water-soluble extractive, root of purple-flowered peucedanum water-soluble extractive, Wu Zhu are water-soluble Extract, rhizoma alismatis water-soluble extractive it is one or more.
Further, the composition also contains 10-120 parts by weight Emulsifier, and emulsifier is selected from water soluble emulsifier, liposoluble One or both of property emulsifier.
Preferably, water soluble emulsifier is selected from polyoxyethylene sorbitan monoleate, polysorbate 60, polysorbate 40, polysorbate 20, ten Sodium dialkyl sulfate, neopelex, odium stearate, enuatrol, sodium laurate, ethylenediamine, triethanolamine, octadecane Base front three ammonium chloride, PLURONICS F87, Emulsifier EL-60, Crodaret, polyoxyl 10 oleyl ether, polyoxy It is one or more in vinyl alkyl ether, polyoxyethylene laurel ether, Myrj 45；Fat-soluble emulsifier is selected from bay Sorb is smooth, Sorbitan Palmitate, Sorbitan Stearate, Sorbitan Oleate, Sorbitan Trioleate, half Sorbitan Oleate, soybean lecithin, changes Property soybean lecithin, egg yolk lecithin, enzymatic hydrolysis of soybean phosphatide, calcium dodecyl benzene sulfonate, dimethyl tertiary amine, sucrose it is stearic It is one or more in acid esters, cholesterol, Arabic gum, xanthans, gelatin, agar.
Further, the composition also contains 0.1-2 parts by weight antioxidants, and antioxidant is selected from Water-soluble antioxidant One or both of agent, fat-soluble antioxidant.
Preferably, the one kind or more of water soluble antioxidant in ascorbic acid, ascorbyl palmitate, tea polyphenols Kind；Fat-soluble antioxidant is selected from butylated hydroxy anisole, dibutyl hydroxy toluene, tert-butyl hydroquinone, gallic acid third It is one or more in ester, tocopherol, Quercetin.
Further, it is 100nm-500 μm that the composition, which is scattered in the grain size in aqueous medium,.
Preferably, the composition is used to prepare tablet, pulvis, granule or liquid preparation.
Preferably, also containing one or more in filler, adhesive, disintegrant, lubricant in tablet；In pulvis also Containing one or more in filler, lubricant；Also containing in filler, adhesive, disintegrant, lubricant in granule It is one or more.
Wherein, filler is selected from microcrystalline cellulose, Macrogol 4000, Macrogol 6000, mannitol, sorbierite, paste It is one or more in essence, lactose, amylum pregelatinisatum, modified starch, calcium sulfate；Adhesive be selected from hydroxypropyl methyl cellulose, Sodium carboxymethylcellulose, povidone, methylcellulose, hydroxypropyl cellulose, ethyl cellulose, gelatin, carbomer or starch slurry One or more of；Disintegrant is selected from crospovidone, croscarmellose sodium, low-substituted hydroxypropyl cellulose, hydroxyl It is one or more in guanidine-acetic acid sodium starch, sodium carboxymethyl starch, calcium carboxymethylcellulose, sodium alginate；Lubricant, which is selected from, to be slided Mountain flour, superfine silica gel powder, magnesium stearate, silica, fumaric acid sodium, hydrogenated vegetable oil, stearic acid, micronized poloxamers, richness Horse odium stearate, sldium lauryl sulfate, polyethylene glycol, lauryl sodium sulfate, Stepanol MG, magnesium laurylsulfate, It is one or more in fumaric acid, glycerine behenic acid.
Further, the micro-capsule compound powder containing oils, which has, is applied to prepare solid food, liquid food or half admittedly Purposes in body food.
Preferably, solid food is steamed bun, steamed twisted roll, noodles, dumpling, bread, cake, biscuit, candy or solid seasoning； Liquid food is beverage or dairy produce；Semi-solid food products are g., jelly-like food, paste food or paste food.
Further, the preparation process of the micro-capsule compound powder containing oils includes the following steps：
1) at 40-80 DEG C, by the oil phase of no special odor, fat-soluble nutrients ingredient, oil phase corrigent, fat-soluble emulsification Agent, fat-soluble antioxidant ingredient are mixed evenly, and are prepared into oil phase；
2) at 50-80 DEG C, capsule material, water phase corrigent, water-soluble nutritional ingredient, water soluble emulsifier, water solubility is anti- Oxidant after mixing, is slowly added into water or solvent aqueous solution, stirs while adding, until capsule material, water-emulsifiable Agent, water soluble antioxidant, water-soluble nutritional ingredient are completely dissolved, and are prepared into water phase, water or solvent aqueous solution and are dissolved original The mass ratio of material is 4: 1-19: 1；
3) at 25 DEG C, when mixing speed is 200-1000rpm, oil phase is mixed with water conjunction emulsification and obtains breast within 0.5-3 hours Liquid, or lotion is obtained into reprocessing lotion through re-treating process, re-treating process is selected high pressure homogenization method, colloidal grinding method, is squeezed Go out one kind in method, high shear dispersion method, ultrasonic method；
4) by lotion or the reprocessing spray-dried obtained microcapsule powder of lotion, the inlet air temperature of spray drying is 150-190 DEG C, leaving air temp is 80-110 DEG C.
Wherein, in step 3), high pressure homogenization method：Material is in high pressure homogenizer, when passing through operating valve, in 10-100MPa Strong shearing, shock and cavitation are generated under high pressure, to make liquid obtain micronization.
Colloidal grinding method：Fluid foods by between the opposite fixed tooth and moving teeth interlocked of high speed, by powerful shearing force, The effects that friction and high-frequency vibration, material is pulverized, emulsification, homogeneous, mixing, to obtain the product of retrofit
Extrusion molding；Material, using motive force, makes material be forced through intrinsic silicon in the sealing injection device of mini-extruder extrusion instrument Film, to obtain uniform nanoparticle.
High shear dispersion method：Material is put into high-shearing dispersion emulsifying machine, rotor and stator run at high speed, and are formed strong Strong aquashear and turbulent flow, dispersed material, while generating to centrifuge and the comprehensive functions power such as squeeze, mill, colliding, finally make material It is sufficiently mixed, stirs, refines.
Ultrasonic method：By the ultrasonic activation that ultrasonic emulsification instrument generates, and this vibrational energy is sent out into liquid material It penetrates, material is by dispersion and emulsion at thin nano-particle.
In order to overcome some fat-soluble compositions (itself not have bad smell, but work as they and certain nutritional ingredients Just will produce the fat-soluble compositions of bad smell when combination) possessed by bad smell and taste bad taste, the present invention provides one Micro-capsule compound powder and its preparation process of the kind containing oils, the taste for improving this substance, and improve its water solubility. In order to improve the water solubility of such fat-soluble compositions, the present invention by medicine preparation at microcapsule powder, in the water for not only improving oils Solubility and absorption increase drug effect, and mask bad smell.But existing such microcapsule powder product, gas can only be covered Taste cannot cover taste, and mouthfeel does not reach ideal effect, requires further improvement formula and technique.We are creatively Specific oil phase corrigent is applied in the microcapsule powder product of the present invention, it has surprisingly been found that being prepared using this oil phase corrigent Microcapsule powder product, can effectively cover these oil smell and taste, further increase the micro-capsule containing peculiar smell oil components The oral compliance of compound powder can be made into chewable tablets, buccal, granule to expand application range, can be with It is dissolved in water liquid is made drinking.Relative to traditional water phase corrigent, the oil phase for dissolving in oil phase used in the present invention is rectified Taste agent flavoring effect is good, and few dosage can reach fabulous flavoring effect, to improve or shield the undesirable oily raw meat of oils Taste.Oil phase corrigent can also be combined with water phase corrigent is prepared into compound corrigent system, is applied in microcapsule powder product, rectifys Taste effect makes us very satisfied.Oil phase corrigent is the volatile oil distilled from various plants, selects orange oil, ginger Oil, lemon oil, caryophyllus oil, cassia oil, sesame oil, castor oil, orange oil, cinnamon oil, eucalyptus oil, menthol, ennel oil, anise It is sesame oil, cineol, ethyl acetate, wintergreen, oil of badian, patchouli oil, rosemary oil, thyme linaloe oil, litsea citrate oil, old Skin oil, tea oil, nutmeg oil, garlic oil, Blumea oil, citronella oil, geranium oil, lavender oil, rose oil, cnidium oil, chaste tree It is one or more in mustard oil, citrus seed oil, levant storax oil, orange peel tincture, Fructus Forsythiae oil, it is not only green harmless, and also aromatic flavour is held Long, it is excellent flavoring raw material.
It is 100nm-500 μm that the composition of the present invention, which is scattered in the grain size in aqueous medium, this particle size range just can guarantee Micro-capsule can form stable lotion or suspension after being dispersed in water so that oil phase corrigent, which is present in peculiar smell oil phase, to be played Taste masking effect, water phase corrigent, which can also be added, makes it assist to play flavored action.For the patient that inconvenience is swallowed, by microcapsule powder It is made stable lotion or when suspension carries out oral, oil phase corrigent increases the oral compliance of patient.Such as fruit product grain Diameter is more than the scope of the present invention, and microcapsule powder is dispersed in water, and cannot form stable lotion or suspension, and generation is mutually layered, makes Oil phase taste masking and the separation of water phase flavoring are obtained, the collaboration flavoring function of the compound flavoring system of the present invention cannot be formed so that flavoring is imitated Fruit is undesirable.
The present invention also contains nutritional ingredient, has the advantages that complex function, mouthfeel are good, solubility is good, can be used for making Standby new function beverage products.
Specific implementation mode
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase Mutually combination.Below in conjunction with specific embodiment, the present invention will be described in detail.
Embodiment 1
Formula：10g sunflower oils, 10g lutein, 80g casein sodiums, 30g oil of ginger
Technique：At 60 DEG C, sunflower oil, oil of ginger are mixed evenly, oil phase is prepared into.At 70 DEG C, by junket Protein acid sodium, lutein after mixing, are slowly added into water, are stirred while adding, until casein sodium, lutein are complete Fully dissolved is prepared into water phase.The mass ratio of water and dissolved raw material is 12: 1.It, will be oily when mixing speed is 500rpm at 25 DEG C It is mutually mixed with water conjunction emulsification and obtains lotion in 2 hours, lotion is high-pressure homogeneous through 50MPa, reprocessing lotion is made.It will reprocessing breast The spray-dried obtained microcapsule powder of liquid.The inlet air temperature of spray drying is 170 DEG C, and leaving air temp is 95 DEG C.
Embodiment 2
Formula：30g maize germ oils, 180g astaxanthins, 1000g polyethylene, 80g lemon oils
Technique：At 70 DEG C, maize germ oil, astaxanthin, lemon oil are mixed evenly, oil phase is prepared into.60 At DEG C, polyethylene is slowly added into water, is stirred while adding, until polyethylene is completely dissolved, is prepared into water phase.Water and institute The mass ratio for dissolving raw material is 19: 1.At 25 DEG C, when mixing speed is 100rpm, oil phase is mixed with water conjunction, emulsification obtains for 1 hour To lotion.By the spray-dried obtained microcapsule powder of lotion.The inlet air temperature of spray drying is 160 DEG C, and leaving air temp is 90 DEG C.
Embodiment 3
Formula：100g soybean oils, 50g lutein, 800g gelatin, 30g oil of ginger, 25g steviosides, 60g polysorbate 60s
Technique：At 50 DEG C, soybean oil, lutein, oil of ginger are mixed evenly, oil phase is prepared into.At 60 DEG C, After mixing by gelatin, stevioside, polysorbate 60, it is slowly added into water, stirs while adding, until gelatin, stevia rebaudianum Glycosides, polysorbate 60 are completely dissolved, and are prepared into water phase.The mass ratio of water and dissolved raw material is 8: 1.At 25 DEG C, mixing speed For 400rpm when, oil phase is mixed with water conjunction, emulsification obtains lotion in 2 hours, and lotion is high-pressure homogeneous through 100MPa, and high pressure is made Homogeneous lotion.By the spray-dried obtained microcapsule powder of high-pressure homogeneous lotion.The inlet air temperature of spray drying is 150 DEG C, goes out wind-warm syndrome Degree is 80 DEG C.
Embodiment 4
Formula：10g Rice oils, 50g vitamin As, 500g sodium alginates, 50g sesame oil, 30g watermelon juice powder, 20g grapes Sugar, 0.1g ascorbic acid
Technique：At 80 DEG C, Rice oil, sesame oil, vitamin A are mixed evenly, oil phase is prepared into.At 80 DEG C Under, after mixing by sodium alginate, watermelon juice powder, glucose, ascorbic acid, it is slowly added into water, stirs while adding, It is completely dissolved until by sodium alginate, vitamin B, watermelon juice powder, glucose, ascorbic acid, is prepared into water phase.Water with dissolved The mass ratio of raw material is 4: 1.At 25 DEG C, when mixing speed is 800rpm, oil phase is mixed with water conjunction, emulsification obtains breast in 1 hour Liquid, lotion is high-pressure homogeneous through 100MPa, high-pressure homogeneous lotion is made.By the spray-dried obtained micro-capsule of high-pressure homogeneous lotion Powder.The inlet air temperature of spray drying is 160 DEG C, and leaving air temp is 95 DEG C.
Embodiment 5
Formula：50g rice bran oils, 100g oryzanol, 20g collagens, 400g casein sodiums, 10g lemon oils, 25g fruits Sugar
Technique：At 40 DEG C, rice bran oil, lemon oil, oryzanol are mixed evenly, oil phase is prepared into.At 50 DEG C, After mixing by casein sodium, collagen, fructose, it is slowly added into water, stirs while adding, until by casein Sour sodium, collagen, fructose are completely dissolved, and are prepared into water phase.The mass ratio of water and dissolved raw material is 9: 1.At 25 DEG C, stirring When speed is 1000rpm, oil phase is mixed with water conjunction, emulsification obtains lotion in 0.5 hour, and reprocessing lotion is prepared with ultrasonic method. The spray-dried obtained microcapsule powder of lotion will be reprocessed.The inlet air temperature of spray drying is 190 DEG C, and leaving air temp is 110 DEG C.
Embodiment 6
Formula：80g soybean oils, 10g linoleic acid, 200g collagens, 800g dextrin, 100g orange oils, 5g saccharin sodiums, 10g malic acid
Technique：At 50 DEG C, soybean oil, orange oil, linoleic acid are mixed evenly, oil phase is prepared into.At 60 DEG C, After mixing by dextrin, collagen, saccharin sodium, malic acid, be slowly added into water, stir while adding, until dextrin, Collagen, saccharin sodium, malic acid are completely dissolved, and are prepared into water phase.The mass ratio of water and dissolved raw material is 15: 1.25 DEG C, when mixing speed is 800rpm, oil phase is mixed with water conjunction emulsification and obtains lotion within 1 hour, lotion is equal through 10MPa high pressures Reprocessing lotion is made in matter.The spray-dried obtained microcapsule powder of lotion will be reprocessed.The inlet air temperature of spray drying is 160 DEG C, Leaving air temp is 100 DEG C.
Embodiment 7
Formula：50g sunflower oils, 50g grape seed oils, 50g curcumins, 80g l-cns, 500g, dextrin, 100g orange peels Oil, 5g honey elements, 60g polyoxyethylene sorbitan monoleates
Technique：At 70 DEG C, sunflower oil, grape seed oil, curcumin, orange oil are mixed evenly, oil is prepared into Phase.It at 70 DEG C, after mixing by dextrin, l-cn, honey element, polyoxyethylene sorbitan monoleate, is slowly added into water, side is added Side is stirred, and is completely dissolved until by dextrin, l-cn, honey element, polyoxyethylene sorbitan monoleate, is prepared into water phase.Water and dissolve original The mass ratio of material is 12: 1.At 25 DEG C, when mixing speed is 600rpm, oil phase is mixed with water conjunction, emulsification obtains breast in 3 hours With high shear dispersion method reprocessing lotion is made in lotion by liquid.The spray-dried obtained microcapsule powder of lotion will be reprocessed.Spraying is dry Dry inlet air temperature is 150 DEG C, and leaving air temp is 90 DEG C.
Embodiment 8
Formula：50g wheat-germ oils, 30g lutein esters, 20g collagens, 500g fish glue, 50g orange oils, 9g are happy Element, 60g polyoxyethylene sorbitan monoleates, 60g Sorbitan Laurates, 2g butylated hydroxy anisoles
Technique：At 60 DEG C, by wheat-germ oil, lutein ester, orange oil, Sorbitan Laurate, butylated hydroxy anisole It is mixed evenly, is prepared into oil phase.At 65 DEG C, after mixing by fish glue, collagen, honey element, polyoxyethylene sorbitan monoleate, It is slowly added into water, stirs while adding, until fish glue, collagen, honey element, polyoxyethylene sorbitan monoleate are completely dissolved, prepare At water phase.The mass ratio of water and dissolved raw material is 10: 1.At 25 DEG C, when mixing speed is 500rpm, oil phase is mixed with water It closes, emulsification obtains lotion in 2 hours, and lotion is high-pressure homogeneous through 50MPa, and high-pressure homogeneous lotion is made.High-pressure homogeneous lotion is passed through Microcapsule powder is made in spray drying.The inlet air temperature of spray drying is 170 DEG C, and leaving air temp is 100 DEG C.
Embodiment 9
Formula：80g maize germ oils, 100g lutein, 100g l-cns, 1000g casein sodiums, 30g orange oils, 1g saccharin sodiums, 10g polyoxyethylene sorbitan monoleates, 1g butylated hydroxy anisoles
Technique：At 60 DEG C, maize germ oil, orange oil, lutein, butylated hydroxy anisole are mixed evenly, It is prepared into oil phase.At 70 DEG C, after mixing by casein sodium, saccharin sodium, l-cn, polyoxyethylene sorbitan monoleate, slowly add Enter into water, stir while adding, until casein sodium, saccharin sodium, l-cn, polyoxyethylene sorbitan monoleate are completely dissolved, prepares At water phase.The mass ratio of water and dissolved raw material is 19: 1.At 25 DEG C, when mixing speed is 500rpm, oil phase is mixed with water It closes emulsification and obtains lotion in 2 hours, lotion is high-pressure homogeneous through 50MPa, reprocessing lotion is made.Reprocessing lotion is done through spraying Dry obtained microcapsule powder.The inlet air temperature of spray drying is that 170 DEG C of leaving air temps are 95 DEG C.
Embodiment 10
Formula：10g sunflower oils, 30g leukotrienes, 200g dextrin, 80g lemon oils, 25g steviosides, 200g hyaluronic acids, 60g polysorbate 60s, 0.1g butylated hydroxy anisoles
Technique：At 40 DEG C, sunflower oil, leukotrienes, lemon oil, butylated hydroxy anisole are mixed evenly, made For at oil phase.At 50 DEG C, after mixing by dextrin, stevioside, hyaluronic acid, polysorbate 60, it is slowly added into water, It stirs while adding, until dextrin, stevioside, hyaluronic acid, polysorbate 60 are completely dissolved, is prepared into water phase.Water and institute are molten The mass ratio for solving raw material is 4: 1.At 25 DEG C, when mixing speed is 1000rpm, oil phase is mixed with water conjunction emulsification and is obtained within 0.5 hour To lotion.By the spray-dried obtained microcapsule powder of lotion.The inlet air temperature of spray drying is 180 DEG C, and leaving air temp is 100 DEG C
Embodiment 11
Formula：30g ethyl oleates, 10g heme irons, 800g gelatin, 100g sesame oil, 20g sucrose, 200g collagen eggs In vain, 30g polysorbate 40s, 50g soybean lecithins, 1.5g ascorbic acid
Technique：At 50 DEG C, ethyl oleate, heme iron, sesame oil, soybean lecithin are mixed evenly, are prepared into Oil phase.At 60 DEG C, after mixing by gelatin, sucrose, collagen, polysorbate 40, ascorbic acid, it is slowly added into water In, it stirs while adding, until obviously glue, sucrose, collagen, polysorbate 40, ascorbic acid are completely dissolved, is prepared into water Phase.The mass ratio of water and dissolved raw material is 15: 1.When 25 DEG C of mixing speeds are 500rpm, oil phase is mixed with water conjunction emulsification Obtain lotion within 3 hours, reprocessing lotion is made with colloidal grinding method in lotion.It is spray-dried obtained micro- that lotion will be reprocessed Capsule powder.The inlet air temperature of spray drying is 150 DEG C, and leaving air temp is 80 DEG C.
Embodiment 12
Formula：100g peanut oil, 180g sheep placentas, 500g agar, 10g caryophyllus oils, 30g lemon juice powder, 20g water solubilitys day Right essence, 150g aloe water-soluble extractives, 20g polysorbate 60s, 30g Sorbitan Laurates, 0.5g tea polyphenols
Technique：At 80 DEG C, peanut oil, sheep placenta, caryophyllus oil, Sorbitan Laurate are mixed evenly, oil is prepared into Phase.At 70 DEG C, by agar, lemon juice powder, water-soluble natural essence, aloe water-soluble extractive, polysorbate 60, tea polyphenols After mixing, it is slowly added into water, stirs while adding, until agar, lemon juice powder, water-soluble natural essence, aloe Water-soluble extractive, polysorbate 60, tea polyphenols are completely dissolved, and are prepared into water phase.The mass ratio of water and dissolved raw material is 10: 1.When 25 DEG C of mixing speeds are 800rpm, oil phase is mixed with water conjunction emulsification and obtains lotion within 1.5 hours, by lotion ultrasonic method Prepare reprocessing lotion.The spray-dried obtained microcapsule powder of lotion will be reprocessed.The inlet air temperature of spray drying is 190 DEG C, is gone out Air temperature is 110 DEG C.
Reference examples 1
Formula：50g soybean oils, 30g lutein esters, 20g collagens, 500g fish glue, 9g steviosides, 60g polysorbates 60,60g Sorbitan Laurates, 2g butylated hydroxy anisoles
Technique：At 60 DEG C, soybean oil, lutein ester, Sorbitan Laurate, butylated hydroxy anisole are mixed equal It is even, it is prepared into oil phase.At 65 DEG C, after mixing by fish glue, collagen, stevioside, polysorbate 60, it is slowly added into It in water, stirs while adding, until fish glue, collagen, stevioside, polysorbate 60 are completely dissolved, is prepared into water phase.Water with The mass ratio of dissolved raw material is 10: 1.At 25 DEG C, when mixing speed is 500rpm, oil phase is mixed with water conjunction, is emulsified 2 hours Lotion is obtained, lotion is high-pressure homogeneous through 50MPa, high-pressure homogeneous lotion is made.High-pressure homogeneous lotion is spray-dried obtained Microcapsule powder.The inlet air temperature of spray drying is 170 DEG C, and leaving air temp is 100 DEG C.
Reference examples 2
Formula：10g sunflower oils, 30g leukotrienes, 80g lemon oils, 25g steviosides, 200g hyaluronic acids, 60g soybean phosphorus Fat, 0.1g butylated hydroxy anisoles
Technique：At 40 DEG C, sunflower oil, leukotrienes, lemon oil, soybean lecithin butylated hydroxy anisole are mixed Uniformly, it is prepared into oil phase.It at 50 DEG C, after mixing by stevioside, hyaluronic acid, is slowly added into water, when being added Stirring is prepared into water phase until stevioside, hyaluronic acid are completely dissolved.The mass ratio of water and dissolved raw material is 4: 1.25 DEG C, when mixing speed is 1000rpm, oil phase is mixed with water conjunction emulsification and obtains lotion within 0.5 hour.
Reference examples 3
Formula：50g wheat-germ oils, 30g curcumins, 20g collagens, 500g dextrin, 60g polyoxyethylene sorbitan monoleates, the 60g months Osmanthus sorb is smooth, 2g butylated hydroxy anisoles
Technique：At 60 DEG C, wheat-germ oil, curcumin, Sorbitan Laurate, butylated hydroxy anisole are mixed equal It is even, it is prepared into oil phase.At 65 DEG C, after mixing by dextrin, collagen, polyoxyethylene sorbitan monoleate, it is slowly added into water, side Side stirring is added and is prepared into water phase until dextrin, collagen, polyoxyethylene sorbitan monoleate are completely dissolved.The matter of water and dissolved raw material Amount is than being 10: 1.At 25 DEG C, when mixing speed is 500rpm, oil phase is mixed with water conjunction, emulsification obtains lotion in 2 hours, will be newborn Liquid is high-pressure homogeneous through 50MPa, and high-pressure homogeneous lotion is made.By the spray-dried obtained microcapsule powder of high-pressure homogeneous lotion.Spraying is dry Dry inlet air temperature is 170 DEG C, and leaving air temp is 100 DEG C.
Reference examples 4
Formula：100g peanut oil, 180g sheep placentas, 50g agar, 5g caryophyllus oils, 30g lemon juice powder, 20g water-soluble naturals Essence, 150g aloe water-soluble extractives, 50g polysorbate 60s, 0.5g tea polyphenols
Technique：At 80 DEG C, peanut oil, sheep placenta, caryophyllus oil are mixed evenly, oil phase is prepared into.At 70 DEG C, After mixing by agar, lemon juice powder, water-soluble natural essence, aloe water-soluble extractive, polysorbate 60, tea polyphenols, It is slowly added into water, stirs while adding, until agar, lemon juice powder, water-soluble natural essence, the extraction of aloe water solubility Object, polysorbate 60, tea polyphenols are completely dissolved, and are prepared into water phase.The mass ratio of water and dissolved raw material is 10: 1.It is stirred at 25 DEG C When to mix speed be 800rpm, oil phase is mixed with water conjunction emulsification and obtains lotion within 1.5 hours, lotion is prepared with ultrasonic method and is reprocessed Lotion.
Reference examples 5
Formula：100g peanut oil, 180g sheep placentas, 1200g polyethylene glycol, 150g caryophyllus oils, 30g lemon juice powder, 20g water Soluble natural essence, 150g aloe water-soluble extractives, 20g polysorbate 60s, 30g soybean lecithins, 0.Sg tea polyphenols
Technique：At 80 DEG C, peanut oil, sheep placenta, caryophyllus oil, soybean lecithin are mixed evenly, oil phase is prepared into. It is at 70 DEG C, polyethylene glycol, lemon juice powder, water-soluble natural essence, aloe water-soluble extractive, polysorbate 60, tea is more Phenol after mixing, is slowly added into water, is stirred while adding, until polyethylene glycol, lemon juice powder, water-soluble natural are fragrant Essence, aloe water-soluble extractive, polysorbate 60, tea polyphenols are completely dissolved, and are prepared into water phase.The quality of water and dissolved raw material Than being 19: 1.At 25 DEG C, when mixing speed is 800rpm, oil phase is mixed with water conjunction emulsification and obtains lotion within 1.5 hours, by lotion Reprocessing lotion is prepared with ultrasonic method.The spray-dried obtained microcapsule powder of lotion will be reprocessed.The inlet air temperature of spray drying is 190 DEG C of leaving air temps are 110 DEG C
Test experience
Mouthfeel detects
15-75 Sui subject 30, every ten years old is an age bracket, 5 subjects of each age bracket.By embodiment sample It is dissolved in the liquid that distilled water is prepared into a concentration of 10% with reference examples sample, sample liquid is upset into sequence and is marked again Number.Each tester tastes sample successively by label, drinks a kind of sample and need to only be stopped in mouth 5 seconds and is not swallowed, Judge mouthfeel score, is gargled with clear water after discharge sample, next sample is tasted after 1 minute, until having tasted all detected samples Product.The accumulation score of each sample.The temperature of sample and clear water is maintained at 20 ± 2 DEG C during experiment.Sample mouthfeel point Value standard is：Mouthfeel is very good, and --- 3 points of --- 4 points, mouthfeel is general --- 5 points, in good taste, poor taste --- 2 points, mouthfeel is very Difference --- 1.
Droplet measurement：1,3,5 sample of freshly prepd embodiment 1-12 and reference examples is taken respectively, is diluted with distilled water into concentration For 10% liquid, the initial volume average grain diameter (X of freshly prepared liquid is measured with Malvern laser particle size analyzer0).It will be new The embodiment 1-12 and 1,3,5 sample of reference examples of preparation are placed 30 days, are diluted with distilled water into a concentration of 10% liquid, it uses Malvern laser particle size analyzer measures 30 days volume average particle sizes (X1) of sample after placing 30 days, calculates volume average particle size Increase than (X), calculation formula is X%=(X1-X0)/X0。
Breast analysis index (CI)：Breast analysis index is the important indicator for evaluating liquid stability.Take freshly prepd embodiment 1-12 With 1,3,5 sample of reference examples, it is diluted with distilled water into a concentration of 10% liquid, liquid is placed in the glass of 1.0cm × 15cm In test tube, emulsion is divided into two layers after placing 10 days at normal temperatures, and upper layer is breast analysis layer, and lower layer is supernatant layer, records Ru Xi circle Face height.Breast analysis index (CI) is the height (H of subnatantC) with the height (H of entire lotionE) ratio, i.e. CI (%)= (HC/HE) × 100%.
Since reference examples 2 and 4 sample of reference examples do not contain capsule material, micro-capsule can not be formed, so not measuring grain size and breast analysis Index.
The performance test results of table 1 embodiment and reference examples
The grain size and breast analysis index of embodiment and reference examples sample dispersion in aqueous medium are had recorded in table 1, are also remembered The mouthfeel detection data of embodiment and reference examples is recorded.Reference examples 2 and reference examples 4 are not microcapsule powder forms, other embodiment and Reference examples are microcapsule powder form, the embodiment and reference examples of microcapsule powder form the difference is that：Contain this in embodiment The oil phase corrigent of peculiar dosage is invented, and reference examples 1 and reference examples 3 are free of oil phase corrigent, the oil phase corrigent of reference examples 5 It is beyond the scope of the present invention, lead to the poor taste of reference examples.The mouthfeel evaluation score value of embodiment 1-12 is all higher than 120 Point, show the good mouthfeel of 12 embodiments；The capsule material dosage of 12 embodiment samples is within the scope of the present invention, micro- The initial volume average grain diameter of capsule compound powder is respectively less than 500 μm, and volume average particle size increases ratio between 0.7--1.3, breast analysis Between index 0.6%--1.3%.The capsule material dosage of reference examples 1 and reference examples 3 is reasonable, the micro-capsule compound powder of the two it is initial Volume average particle size is close with embodiment, respectively 284.6 μm and 316.8 μm, the volume average particle size of the two increase than and Breast analysis index is also not much different with embodiment, but due to being free of oil phase corrigent in reference examples 1 and reference examples 3, so they Mouthfeel it is more far short of what is expected than embodiment, it is respectively 81 points and 86 points to comment mouthfeel to determine score value.Reference examples 2 are free of capsule material, the capsule of reference examples 4 Timber-used amount is few, and the two cannot form microcapsule powder sample, therefore need not measure their grain size and breast analysis index；Reference examples 5 Capsule material dosage exceeds protection domain, and initial volume average grain diameter is more than 500 μm, and 30 days volume average particle sizes, average grain diameter increase It is long more poor than with breast analysis index；And the mouthfeel evaluation score value of reference examples 2, reference examples 4 and reference examples 5 is respectively less than 90 points. It is apparent that this shows that the capsule material of scientific and reasonable dosage and oil phase corrigent act on the oils for improving poor taste, capsule material prepare it is micro- During capsule powder, there is vital influence to the particle size that is scattered in aqueous medium, liquid stability.Pass through overall point The mouthfeel of embodiment sample solution is good known to analysis, and microcapsule powder is scattered in that grain size in aqueous medium is small and liquid stabilising, is the present invention Scientific and reasonable formula.
It can be seen from the above description that the above embodiments of the present invention realize following technique effect：In order to overcome Maize germ oil, soybean oil, wheat-germ oil, sunflower oil, rice bran oil, Rice oil, grape seed oil, pungent certain herbaceous plants with big flowers acid glyceride etc. are originally Oil and the combination of the fat-soluble nutrients ingredient such as lutein, lutein ester, astaxanthin, Radix salaciae prinoidis extract of body free from extraneous odour and generate The problem of bad smell and poorly water-soluble, is prepared into the microcapsule powder wrapped up by capsule material, wherein also containing oil phase corrigent.With use Traditional flavoring mode of single-phase corrigent is compared, and oil phase corrigent and microcapsule powder technique are used cooperatively with fabulous by the present invention Flavoring effect, be effectively improved or shield the undesirable oily fishy smell of peculiar smell oil components, the product oral compliance of preparation is good, mouthfeel Good, free from extraneous odour.Oil phase corrigent is the volatile oil distilled from various plants, not only green harmless, but also aromatic flavour Persistently, it is excellent flavoring raw material.Microcapsule powder prepared by the present invention can be good at soluble in water, and be scattered in aqueous medium Grain size it is small, can form stable lotion or suspension, improve solubility and bioavilability in the water of peculiar smell oil components, increase Strong drug effect.The present invention also contains nutritional ingredient, has the advantages that complex function, mouthfeel are good, solubility is good, can be used for preparing New function beverage products.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by repair Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.

Claims (27)

1. a kind of micro-capsule compound powder containing oils, which is characterized in that containing oil phase of the 10-100 parts by weight without special odor, 10-180 parts by weight fat-soluble nutrients ingredient, 80-1000 parts by weight capsule material and 10-100 parts by weight oil phase corrigents.
2. composition according to claim 1, which is characterized in that containing oil phase of the 30-80 parts by weight without special odor, 30-100 parts by weight fat-soluble nutrients ingredient, 200-800 parts by weight capsule material and 30-80 parts by weight oil phase corrigents.
3. composition according to claim 1, which is characterized in that contain oil phase of 50 parts by weight without special odor, 50 weights Measure part fat-soluble nutrients ingredient, 500 parts by weight capsule materials and 50 parts by weight oil phase corrigents.
4. according to any compositions of claim 1-3, which is characterized in that the oil phase of the no special odor is selected from jade Rice germ oil, soybean oil, wheat-germ oil, sunflower oil, rice bran oil, Rice oil, grape seed oil, pungent certain herbaceous plants with big flowers acid glyceride, oleic acid Ethyl ester, olive oil, Semen setariae oil, rapeseed oil, peanut oil, tea oil, palm oil, Canola oil, walnut oil, peony seed oil, kardiseed Oil, cotton seed oil, coconut oil, apricot kernel oil, oleic acid, oleyl alcohol, octadecyl alcolol, 18 hexadecanols, atoleine, hydrogenated groundnut, hydrogenation It is one or more in cotton seed oil, glycerol monostearate acid esters, isopropyl myristate, ethanedioic acid monostearate, lanonol.
5. according to any compositions of claim 1-3, which is characterized in that the fat-soluble nutrients ingredient is selected from frog Oil, allicin, turmeric, curcumin, oryzanol, sensitiveplant-like senna seed phenol, camellia seed extract, leukotrienes, linoleic acid, sheep placenta, leaf Flavine, lutein ester, fish oil, chromium picolinate, phosphatide, propolis, gangliosides, astaxanthin, carrotene, vitamin A, blood Red pigment iron, gynostemma pentaphylla, Radix salaciae prinoidis extract, can salad is uncommon, oyster, scurvy grass, milk thistle, basyleave, one kind in sulphur octanol Or it is a variety of.
6. according to any compositions of claim 1-3, which is characterized in that the capsule material is selected from dextrin, agar, bright Glue, Arabic gum, gelatine, fish glue, oligomeric maltose, casein sodium, sodium alginate, fibrin, ethyl cellulose, nitric acid Cellulose, carboxymethyl cellulose, cellulose acetate, hydroxypropyl methyl cellulose, cellulose acetate phthalate, acetate fiber Plain butyl ester, cellulose acetate phthalate ester, polyethylene glycol, polyvinyl chloride, polystyrene, poly- carbon ester, polyamide, polylactic acid, dioxy It is one or more in SiClx, modified starch.
7. according to any compositions of claim 1-3, which is characterized in that the oil phase corrigent be selected from orange oil, Oil of ginger, lemon oil, caryophyllus oil, cassia oil, sesame oil, castor oil, orange oil, cinnamon oil, eucalyptus oil, menthol, ennel oil, Aniseed oil, cineol, ethyl acetate, wintergreen, oil of badian, patchouli oil, rosemary oil, thyme linaloe oil, the fruit of a cubeb litsea tree Oil, Oleum Citri Reticulatae, tea oil, nutmeg oil, garlic oil, Blumea oil, citronella oil, geranium oil, lavender oil, rose oil, Rhizoma Chuanxiong It is one or more in oil, catnip oil, citrus seed oil, levant storax oil, orange peel tincture, Fructus Forsythiae oil, butter essence, butter；Preferably, institute The oil phase corrigent stated is selected from orange oil, oil of ginger, lemon oil, caryophyllus oil, fennel oil, cassia oil sesame oil, castor oil, sweet orange It is one or more in oil.
8. according to any compositions of claim 1-3, which is characterized in that also contain 1-50 parts by weight water-soluble flavorings Agent.
9. composition according to claim 8, which is characterized in that the water phase corrigent is selected from acidic flavouring agent, sweet tea It is one or more in taste agent, tasty agents, essence, natural fruit vegetable juice powder, mucilage, fumet, dairy produce.
10. composition according to claim 9, which is characterized in that the acidic flavouring agent is selected from vitamin C, apple It is one or more in acid, citric acid；The sweetener is selected from saccharin sodium, stevioside, Aspartame, neotame, honey, trichlorine Sucrose, honey element, Radix Glycyrrhizae, acesulfame potassium, A Shasufa, Tagatose, disodium glycyrrhizinate, glucose, fructose, sucrose, xylitol, list It is one or more in syrup, fruit juice syrup；The tasty agents is selected from sodium glutamate, asparatate, amion acetic acid, L- third It is one or more in propylhomoserin, disodium succinate, Sodium guanylate, inosine acid disodium, chickens' extract；The essence is selected from water solubility Natural essence, water-soluble compound essence, water-soluble natural are equal one or more in essence, water-soluble fermentation essence；It is described Natural fruit vegetable juice powder be selected from lemon juice powder, mint juice powder, ginger juice powder, orange juice powder, pineapple juice powder, water pear juice powder, watermelon Juice powder, apple juice powder, Fresh Cucumber Juice powder, grape juice powder, kiwi-fruit juice powder, Passion Fruit Juice powder, strawberry juice powder, mango juice powder, sugarcane Juice powder, Chinese flowering quince juice powder, asparagus juice powder, tomato juice powder, Celery Juice powder, spinach juice powder, carrot juice powder, pimento juice powder, green pepper juice powder In it is one or more；The mucilage is selected from sodium carboxymethylcellulose, methylcellulose, guar gum, tragacanth, Huang Virgin rubber, Bletilla glucomannan, carbomer, polyvinyl alcohol, povidone, gelatin it is one or more；The fumet is selected from maltol, second It is one or more in base maltol, methyl cyclopentenyl ketone.
11. according to any compositions of claim 1-3, which is characterized in that also contain 20-200 parts by weight water-soluble and seek It forms point.
12. composition according to claim 11, which is characterized in that the water-soluble nutritional ingredient is selected from collagen egg In vain, l-cn, vitamin C, barley element, calcium pantothenate, algin, black tea polyphenols, inositol, carob, albumen peptide, hyalomitome Acid, chondroitin sulfate, Cassia bean gum, L-arginine, Arabic gum, ferulic acid, γ-aminobutyric acid, Glucosamine, half Guang ammonia Acid, galactomannan, L-thiamine, tea polyphenols, superoxide dismutase, antierythrite, soybean protein, soy oligosaccharides Peptide, soyabean oligosaccharides, isoflavones, single glucose glycyrrhizin, Yolk immune globulin, galactooligosaccharide, oligomeric gala Uronic acid, oligofructose, oligomeric synanthrin, oligomeric dragon gallbladder sugar, oligomeric maltose, xylo-oligosaccharide, lactosucrose, oligomeric fiber It is sugar, oligoisomaltose, reduced isomaltooligosaccharide, fructose 1,6-diphosphate, honey, beeswax, royal jelly, ferrous fumarate, sweet Propylhomoserin, mannitol, high F value oligopeptide, L-Glutamine, glutathione, guar gum, guarana beans, alginic acid oligosaccharide, Trehalose, nucleic acid, deodorized red cabbage color, active polysaccharide, blood pressure lowering peptide, ferric pyrophosphate, inulin, polydextrose, cocoa polyphenol, L- rely Propylhomoserin, casein phosphopeptide, casein calcium peptide, ferrous sulfate, lipoic acid, zinc sulfate, chlorogenic acid, maltitol, enzyme modification rue Fragrant glycosides, magnesium gluconate, magnesium lactate, Kiwi extract, tikitiki hemicellulose, gossypose, xylitol, indigestible dextrins, Condense polysaccharide, taurine, Bilberry fruit P.E, coupling sugar, apple polyphenol, vine polyphenol, wine polyphenols, calcium gluconate, Portugal Grape saccharic acid manganese, zinc gluconate, ferrous gluconate, grape seed extract, hydroxycitric acid, agar oligosaccharide, lysozyme, α- Lactoalbumin, emulsification ferric pyrophosphate, lactalbumin, calcium lactate, lactic acid bacteria, Pfansteihl zinc, ferrous lactate, lactitol, newborn iron egg In vain, chromium trichloride, sorbierite, edible mushroom fiber, l threonic acid, Bifidobacterium, stachyose, aspartic acid, calcium aspartate, Vitamin B1, vitamin B2, vitamin B6, vitamin B12, oolong tea extract, sodium selenate, sodium selenite, zinc gluconate, Niacinamide, oat bran, sodium iron ethylene diamine tetra acetate, calcium acetate, N- acetyl-Glucosamine, isomerizing lactose, different malt ketone Sugar, hydroxyl isomaltulose, coriolan, cyanophycin, fat metabolism adjust peptide, N- formyls tyrasamine, bamboo-leaves flavones, transgalactosidation Oligosaccharide, pullulan, Radix Isatidis water-soluble extractive, peppermint water-soluble extractive, Asiatic plantain water-soluble extractive, plantain seed Water-soluble extractive, Rosa roxburghii Tratt water-soluble extractive, radix cyathulae water-soluble extractive, Herba Andrographitis water-soluble extractive, barley seedling water Soluble extract, Radix Angelicae Sinensis water-soluble extractive, Radix Codonopsis water-soluble extractive, earthworm water-soluble extractive, cordyceps sinensis are water-soluble Extract, Rabdosia rubescens water-soluble extractive, Cortex Eucommiae water-soluble extractive, galangal water-soluble extractive, the extraction of pueraria lobata water solubility It is object, gekko water-soluble extractive, seaweed water-soluble extractive, rhodiola root water-soluble extractive, Bee Pollen water-soluble extractive, red It is water-soluble to join water-soluble extractive, Hericium erinaceus water-soluble extractive, Cortex Magnoliae Officinalis water-soluble extractive, sealwort water-soluble extractive, wrinkled giant hyssop Property extract, the membrane of a chicken's gizzard water-soluble extractive, ginger water-soluble extractive, balsam pear water-soluble extractive, blueberry water-soluble extractive, Blue-green algae water-soluble extract, ganoderma lucidum water-soluble extractive, schizophyllum commune water-soluble extractive, aloe water-soluble extractive, green tea water Soluble extract, green alga water-soluble extractive, Folium Apocyni Veneti water-soluble extractive, water-soluble spirulina extract, Siraitia grosvenorii water Soluble extract, red deer bone water-soluble extractive, ant water-soluble extractive, tuber of dwarf lilyturf water-soluble extractive, rosemary are water-soluble Property extract, pawpaw water-soluble extractive, root of Aucklandia lappa Decne water-soluble extractive, natto water-soluble extractive, make vinegar water-soluble extraction Object, great burdock achene water-soluble extractive, colostrum water-soluble extractive, root of bidentate achyranthes water-soluble extractive, sterculia seed water-soluble extractive, Dandelion water-soluble extractive, cattail pollen water-soluble extractive, horse chestnut water-soluble extractive, buckwheat water-soluble extractive, people Join water-soluble extractive, Herba Cistanches water-soluble extractive, nutmeg water-soluble extractive, Chinese cassia tree water-soluble extractive, frankincense water Soluble extract, Radix Notoginseng water-soluble extractive, root bark of white mulberry water-soluble extractive, Ramulus Taxilli water-soluble extractive, Gymnema Sylvestre Water-soluble extractive, enzyme modification Gymnema Sylvestre extract water-soluble extractive, sea-buckthorn water-soluble extractive, Shark cartilage are water-soluble Property extract, Chinese yam water-soluble extractive, Fructus Corni water-soluble extractive, cimicifugae foetidae water-soluble extractive, the stem of noble dendrobium water solubility extraction Object, edible fungus water-soluble extract, vine of multiflower knotweed water-soluble extractive, Salvia japonica water-soluble extractive, the extraction of Echinacea purpurea water solubility Object, Pine Bark water-soluble extractive, spina date seed water-soluble extractive, cynomorium songaricum water-soluble extractive, radix pseudostellariae are water-soluble Extract, Rhizoma Gastrodiae water-soluble extractive, lucid asparagus water-soluble extractive, Semen Cuscutae water-soluble extractive, the extraction of Gallus domesticlus brisson water solubility Object, cortex acanthopanacis water-soluble extractive, Schisandra chinensis water-soluble extractive, west safflower water-soluble extractive, the extraction of American Ginseng water solubility Object, hairyvein agrimony water-soluble extractive, thizoma curculiginis water-soluble extractive, HERBA EPIMEDII water-soluble extractive, mushroom water-soluble extractive, figured silk fabrics Careless water-soluble extractive, saussurea involucrata water-soluble extractive, linseed glue soluble extract, bird's nest water-soluble extractive, onion water Soluble extract, wild chrysanthemum water-soluble extractive, motherwort water-soluble extractive, fructus alpiniae oxyphyllae water-soluble extractive, Herba Epimedii water Soluble extract, white fungus water-soluble extractive, ginkgo leaf water-soluble extractive, cordate houttuynia water-soluble extractive, basyleave are water-soluble Property extract, Antrodia camphorata water-soluble extractive, pearl water-soluble extractive, cape jasmine water-soluble extractive, Semen Hoveniae (Fructus Hoveniae) water solubility carry Take object, dried immature fruit of citron orange water-soluble extractive, umbellate pore furgus water-soluble extractive, Asian puccoon water-soluble extractive, perilla seed water-soluble extractive, thorn Old dentifrice water soluble extract, golden ear water-soluble extractive, black soya bean water-soluble extractive, safflower water-soluble extractive, centella water Soluble extract, root of purple-flowered peucedanum water-soluble extractive, Wu Zhu water-soluble extractives, rhizoma alismatis water-soluble extractive it is one or more.
13. according to any compositions of claim 1-3, which is characterized in that also contain 10-120 parts by weight Emulsifier, breast Agent is selected from one or both of water soluble emulsifier, fat-soluble emulsifier.
14. composition according to claim 13, which is characterized in that the water soluble emulsifier is selected from polysorbate 80, polysorbate 60, polysorbate 40, polysorbate 20, lauryl sodium sulfate, neopelex, odium stearate, Enuatrol, sodium laurate, ethylenediamine, triethanolamine, octadecyl trimethyl ammonium chloride, PLURONICS F87, polyoxyethylene caster Oil, Crodaret, polyoxyl 10 oleyl ether, polyoxyethylene alkyl ether, polyoxyethylene laurel ether, polyoxyethylene stearyl It is one or more in acid esters；The fat-soluble emulsifier is selected from Sorbitan Laurate, Sorbitan Palmitate, Sorbitan Stearate, oil Sour sorb is smooth, Sorbitan Trioleate, half Sorbitan Oleate, soybean lecithin, modified soy bean lipoid, egg yolk lecithin, enzymatic hydrolysis of soybean It is phosphatide, calcium dodecyl benzene sulfonate, dimethyl tertiary amine, sucrose stearate, cholesterol, Arabic gum, xanthans, bright It is one or more in glue, agar.
15. according to any compositions of claim 1-3, which is characterized in that also contain 0.1-2 parts by weight antioxidants, Antioxidant is selected from one or both of water soluble antioxidant, fat-soluble antioxidant.
16. composition according to claim 15, which is characterized in that the water soluble antioxidant is selected from Vitamin C It is one or more in acid, ascorbyl palmitate, tea polyphenols；The fat-soluble antioxidant is selected from butylhydroxy fennel It is one or more in ether, dibutyl hydroxy toluene, tert-butyl hydroquinone, propylgallate, tocopherol, Quercetin.
17. according to any compositions of claim 1-3, which is characterized in that the composition is scattered in aqueous medium Grain size be 100nm-500 μm.
18. according to any compositions of claim 1-3, which is characterized in that the composition is used to prepare tablet, powder Agent, granule or liquid preparation.
19. composition according to claim 18, which is characterized in that the tablet also contains filler, adhesive, collapses It solves one or more in agent, lubricant.
20. composition according to claim 19, which is characterized in that the filler is selected from microcrystalline cellulose, poly- second In glycol 4000, Macrogol 6000, mannitol, sorbierite, dextrin, lactose, amylum pregelatinisatum, modified starch, calcium sulfate It is one or more；The adhesive be selected from hydroxypropyl methyl cellulose, sodium carboxymethylcellulose, povidone, methylcellulose, One or more of hydroxypropyl cellulose, ethyl cellulose, gelatin, carbomer or starch slurry；The disintegrant, which is selected from, to be handed over Join povidone, croscarmellose sodium, low-substituted hydroxypropyl cellulose, sodium starch glycollate, sodium carboxymethyl starch, carboxylic It is one or more in methylcellulose calcium, sodium alginate；The lubricant be selected from talcum powder, superfine silica gel powder, magnesium stearate, Silica, fumaric acid sodium, hydrogenated vegetable oil, stearic acid, micronized poloxamers, rich horse odium stearate, sldium lauryl sulfate, One kind in polyethylene glycol, lauryl sodium sulfate, Stepanol MG, magnesium laurylsulfate, fumaric acid, glycerine behenic acid Or it is a variety of.
21. composition according to claim 18, which is characterized in that the pulvis also contains in filler, lubricant It is one or more.
22. composition according to claim 21, which is characterized in that the filler is selected from microcrystalline cellulose, poly- second In glycol 4000, Macrogol 6000, mannitol, sorbierite, dextrin, lactose, amylum pregelatinisatum, modified starch, calcium sulfate It is one or more；The lubricant is selected from talcum powder, superfine silica gel powder, magnesium stearate, silica, fumaric acid sodium, hydrogenation plant Object oil, stearic acid, micronized poloxamers, rich horse odium stearate, sldium lauryl sulfate, polyethylene glycol, lauryl sodium sulfate, It is one or more in Stepanol MG, magnesium laurylsulfate, fumaric acid, glycerine behenic acid.
23. composition according to claim 18, which is characterized in that the granule also contain filler, adhesive, It is one or more in disintegrant, lubricant.
24. composition according to claim 23, which is characterized in that the filler is selected from microcrystalline cellulose, poly- second In glycol 4000, Macrogol 6000, mannitol, sorbierite, dextrin, lactose, amylum pregelatinisatum, modified starch, calcium sulfate It is one or more；The adhesive be selected from hydroxypropyl methyl cellulose, sodium carboxymethylcellulose, povidone, methylcellulose, One or more of hydroxypropyl cellulose, ethyl cellulose, gelatin, carbomer or starch slurry；The disintegrant, which is selected from, to be handed over Join povidone, croscarmellose sodium, low-substituted hydroxypropyl cellulose, sodium starch glycollate, sodium carboxymethyl starch, carboxylic It is one or more in methylcellulose calcium, sodium alginate；The lubricant be selected from talcum powder, superfine silica gel powder, magnesium stearate, Silica, fumaric acid sodium, hydrogenated vegetable oil, stearic acid, micronized poloxamers, rich horse odium stearate, sldium lauryl sulfate, One kind in polyethylene glycol, lauryl sodium sulfate, Stepanol MG, magnesium laurylsulfate, fumaric acid, glycerine behenic acid Or it is a variety of.
25. preparing solid food, liquid food according to any micro-capsule compound powders containing oils of claim 1-3 Or the purposes in semi-solid food products.
26. purposes according to claim 25, which is characterized in that the solid food is steamed bun, steamed twisted roll, noodles, dumpling Son, bread, cake, biscuit, candy or solid seasoning；The liquid food is beverage or dairy produce；The semisolid Food is g., jelly-like food, paste food or paste food.
27. according to the preparation process of any micro-capsule compound powders containing oils of claim 1-3, which is characterized in that Include the following steps：
(1) at 40-80 DEG C, by the oil phase of no special odor, fat-soluble nutrients ingredient, oil phase corrigent, fat-soluble emulsifier, Fat-soluble antioxidant ingredient is mixed evenly, and is prepared into oil phase；
(2) at 50-80 DEG C, by capsule material, water phase corrigent, water-soluble nutritional ingredient, water soluble emulsifier, Water-soluble antioxidant Agent after mixing, is slowly added into water or solvent aqueous solution, stirs while adding, until capsule material, water soluble emulsifier, water Soluble antioxidant, water-soluble nutritional ingredient are completely dissolved, and are prepared into the matter of water phase, water or solvent aqueous solution and dissolved raw material Amount is than being 4: 1-19: 1；
(3) at 25 DEG C, when mixing speed is 200-1000rpm, oil phase is mixed with water conjunction emulsification and obtains lotion within 0.5-3 hours, Or lotion is obtained into reprocessing lotion through re-treating process, re-treating process is selected high pressure homogenization method, colloidal grinding method, is squeezed out One kind in method, high shear dispersion method, ultrasonic method；
(4) by lotion or the reprocessing spray-dried obtained microcapsule powder of lotion, the inlet air temperature of spray drying is 150-190 DEG C, Leaving air temp is 80-110 DEG C.
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CN109259228A (en) * 2018-11-12 2019-01-25 陕西海斯夫生物工程有限公司 A kind of raw ketone weight-reducing microcapsule powder of full element and preparation method thereof
CN109498597A (en) * 2018-12-07 2019-03-22 佛山市正典生物技术有限公司 A kind of quinocetone pellet and preparation method thereof
CN109464540A (en) * 2018-12-21 2019-03-15 广东方制药有限公司 A kind of alleviation oral cavity and the spray of throat discomfort and preparation method thereof
CN113080457A (en) * 2021-04-15 2021-07-09 南京纽邦生物科技有限公司 Glyceryl tributyrate microcapsule powder and preparation method thereof
CN113080457B (en) * 2021-04-15 2023-04-18 南京纽邦生物科技有限公司 Glyceryl tributyrate microcapsule powder and preparation method thereof
CN113397085B (en) * 2021-06-30 2023-04-25 中国大熊猫保护研究中心 Method for long-distance transportation of pandas edible bamboo shoots
CN114504104A (en) * 2022-01-23 2022-05-17 大连医诺生物股份有限公司 Taste-masking instant lutein ester product, and preparation method and application thereof
CN114601172A (en) * 2022-03-10 2022-06-10 山东若尧特医食品有限公司 Formula food of glutamine composition with special medical application and preparation method thereof
CN114601172B (en) * 2022-03-10 2024-03-19 山东若尧特医食品有限公司 Formula food with special medical application of glutamine composition and preparation method thereof

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