CN108498479A - A kind of filling liquid type empty hard capsule - Google Patents
A kind of filling liquid type empty hard capsule Download PDFInfo
- Publication number
- CN108498479A CN108498479A CN201810339265.2A CN201810339265A CN108498479A CN 108498479 A CN108498479 A CN 108498479A CN 201810339265 A CN201810339265 A CN 201810339265A CN 108498479 A CN108498479 A CN 108498479A
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- CN
- China
- Prior art keywords
- capsule
- added
- hard capsule
- edible oil
- cellulose derivative
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Abstract
The invention discloses a kind of filling liquid type empty hard capsule, including hollow and hard capsule body, the hollow and hard capsule body is mixed and processed by the raw material of following weight percents：Plant cellulose derivative 30 35%, carragheen 10 16% tie gel 0.3 0.37%, and dodecane sodium carbonate 0.5 0.7%, remaining is purified water, and 1.1）Water is added into insulation barrel, after being heated to 70 100 DEG C, plant cellulose derivative is added, stirs evenly 1.2）Mixed solution is cooled to 45 60 DEG C, auxiliary agent is added, continues to be stirred until homogeneous；At the same time, further include edible oil, after edible oil is heated 3 minutes with boiler, naturally cool to room temperature, edible oil after cooling is uniformly applied on capsule die；1.3）Solution temperature is adjusted to 45 55 DEG C, stands 13 hours, capsule production line is sent into and has leisure the first utricule of hard-hearted capsule finished product.The present invention can fill liquid in capsule and the phenomenon of leakage may be not present, and to ensure that the liquid volume accuracy that patient per takes is high, and will not waste medicine.
Description
Technical field
The present invention relates to a kind of filling liquid type empty hard capsules.
Background technology
The empty hard capsule of routine is all used to store medicinal powder on the market at present, human body diseases is treated, when needing to place liquid
Soft capsule or glassware can be used；Using soft capsule, one side human body is not easy to be dissolved absorption after taking, and lengthens the course for the treatment of, separately
On the one hand, soft capsule moisture is high, is easy dilute liquid medicine, reduces drug effect, cost of idleness；Then existed using glassware storage
It is required for determining usage amount when each taking liquid, is excessively not easy to be absorbed by the body, it is excessively few then to influence human body recovery, and every time
Take all can leave residue, cost of idleness in bottle cap or other containers.
In the prior art in empty hard capsule plus when liquid would generally at the sealing of capsule outer walls more than one of strip of paper used for sealing, with
Ensure leakproofness, such empty hard capsule process is complicated, and wastes manufacturing cost, is also required to strip of paper used for sealing when taking first
It removes, and the careless words of patient can take together, influence health.
Invention content
The purpose of the present invention is to provide a kind of filling liquid type empty hard capsules, liquid can be filled in capsule and leakage may be not present
Liquid phenomenon to ensure that the liquid volume accuracy that patient per takes is high, and will not waste liquid.
In order to achieve the above object, the technical scheme is that：
A kind of filling liquid type empty hard capsule, including hollow and hard capsule body, the hollow and hard capsule body is by following weight percents
Raw material is mixed and processed：Plant cellulose derivative 30-35%, carragheen 10-16% tie gel 0.3-0.37%, dodecane carbon
Sour sodium 0.5-0.7%, remaining is purified water；1）Make capsule layer：1.1）Water is added into insulation barrel, is heated to 70-100 DEG C
Afterwards, plant cellulose derivative is added, is uniformly mixed, wherein plant cellulose derivative is preferably hydroxypropyl methylcellulose；
1.2）Mixed solution is cooled to 45-60 DEG C, auxiliary agent is added, continues to be stirred until homogeneous；At the same time, further include edible oil, it will
After edible oil is heated 3 minutes with boiler, room temperature is naturally cooled to, edible oil after cooling is uniformly applied on capsule die；
1.3）Solution temperature is adjusted to 45-55 DEG C, stands 1-3 hours, is sent into capsule production line；1.4）It will be fed into the system of capsule production line
Standby liquid carries out after dipping in glue, molding, is sent into drying box, and drying the temperature inside the box is 40-80 DEG C, relative humidity 40-60%, drying
4-5 hours, the first utricule of empty hard capsule finished product is then made by cutting and according to routine encapsulation production process.
Further include 2）Sealing：2.1）After liquid is filled with just utricule, adhesive is added at the sealed place of capsule, and heat 0.3-
0.8 second, complete capsule sealing.
Catalyst can also be added, it is carbon dioxide to accelerate capsule sealing, the catalyst.
The beneficial effects of the invention are as follows：A kind of filling liquid type empty hard capsule of the present invention, can fill liquid in capsule and
There is no the phenomenon of leakage, to ensure that the liquid volume accuracy that patient per takes is high, and will not waste liquid.
Specific implementation mode
Embodiment 1
A kind of filling liquid type empty hard capsule, including hollow and hard capsule body, the hollow and hard capsule body is by following weight percents
Raw material is mixed and processed：Plant cellulose derivative 30-35%, carragheen 10-16% tie gel 0.3-0.37%, dodecane carbon
Sour sodium 0.5-0.7%, remaining is purified water；1）Make capsule layer：1.1）Water is added into insulation barrel, is heated to 70-100 DEG C
Afterwards, plant cellulose derivative is added, is uniformly mixed, wherein plant cellulose derivative is preferably hydroxypropyl methylcellulose；
1.2）Mixed solution is cooled to 45-60 DEG C, auxiliary agent is added, continues to be stirred until homogeneous；At the same time, further include edible oil, it will
After edible oil is heated 3 minutes with boiler, room temperature is naturally cooled to, edible oil after cooling is uniformly applied on capsule die；
1.3）Solution temperature is adjusted to 45-55 DEG C, stands 1-3 hours, is sent into capsule production line；1.4）It will be fed into the system of capsule production line
Standby liquid carries out after dipping in glue, molding, is sent into drying box, and drying the temperature inside the box is 40-80 DEG C, relative humidity 40-60%, drying
4-5 hours, the first utricule of empty hard capsule finished product is then made by cutting and according to routine encapsulation production process.
Further include 2）Sealing：2.1）After liquid is filled with just utricule, adhesive is added at the sealed place of capsule, and heat 0.3-
0.8 second, complete capsule sealing.
Catalyst can also be added, it is carbon dioxide to accelerate capsule sealing, the catalyst.
The technique can be additionally used in the production of gelatine capsule.
A kind of filling liquid type empty hard capsule of the present embodiment can fill liquid in capsule and the phenomenon of leakage may be not present, with
It ensures that the liquid volume accuracy that patient per takes is high, and medicine will not be wasted.
Claims (3)
1. a kind of filling liquid type empty hard capsule, including hollow and hard capsule body, special type are：The hollow and hard capsule body is by following
The raw material of weight percent is mixed and processed：Plant cellulose derivative 30-35%, carragheen 10-16%, knot gel 0.3-
0.37%, dodecane sodium carbonate 0.5-0.7%, remaining is purified water；1）Make capsule layer：1.1）Water is added into insulation barrel,
After being heated to 70-100 DEG C, plant cellulose derivative is added, is uniformly mixed, wherein plant cellulose derivative is preferred
For hydroxypropyl methylcellulose；1.2）Mixed solution is cooled to 45-60 DEG C, auxiliary agent is added, continues to be stirred until homogeneous；At the same time,
Further include edible oil, after edible oil is heated 3 minutes with boiler, naturally cools to room temperature, edible oil after cooling is uniformly applied
It is put on capsule die；1.3）Solution temperature is adjusted to 45-55 DEG C, stands 1-3 hours, is sent into capsule production line；1.4）It will send
The preparation solution for entering capsule production line carries out after dipping in glue, molding, is sent into drying box, and drying the temperature inside the box is 40-80 DEG C, relatively wet
Degree is 40-60%, dries 4-5 hours, empty hard capsule finished product then is made by cutting and according to routine encapsulation production process
First utricule.
2. a kind of filling liquid type empty hard capsule according to claim 1, it is characterised in that：Further include 2）Sealing：2.1）It will
After liquid is filled with just utricule, adhesive is added at the sealed place of capsule, and heat 0.3-0.8 seconds, complete capsule sealing.
3. a kind of filling liquid type empty hard capsule according to claim 2, it is characterised in that：Catalyst can also be added, accelerate
Capsule seals, and the catalyst is carbon dioxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810339265.2A CN108498479A (en) | 2018-04-16 | 2018-04-16 | A kind of filling liquid type empty hard capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810339265.2A CN108498479A (en) | 2018-04-16 | 2018-04-16 | A kind of filling liquid type empty hard capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108498479A true CN108498479A (en) | 2018-09-07 |
Family
ID=63381985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810339265.2A Pending CN108498479A (en) | 2018-04-16 | 2018-04-16 | A kind of filling liquid type empty hard capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108498479A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641751A (en) * | 2020-09-25 | 2021-04-13 | 广州启键生物科技有限公司 | Filling hollow capsule of hydroxypropyl methylcellulose and algal polysaccharide |
Citations (7)
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|---|---|---|---|---|
| CN103301086A (en) * | 2013-06-05 | 2013-09-18 | 绍兴康可胶囊有限公司 | Plant cellulose hard empty capsule preparation method |
| CN104039311A (en) * | 2011-11-17 | 2014-09-10 | 迈兰公司 | Liquid-filled hard gel capsule pharmaceutical formulations |
| CN105498991A (en) * | 2016-01-20 | 2016-04-20 | 江苏力凡胶囊有限公司 | Hard capsule sealing liquid spraying device and method |
| CN105663090A (en) * | 2016-01-07 | 2016-06-15 | 中山大学 | Slow release cubic liquid crystal liquid hard capsule and preparation method thereof |
| CN205518268U (en) * | 2016-01-20 | 2016-08-31 | 江苏力凡胶囊有限公司 | Device of sealed liquid spraying of ebonite bag |
| CN106466303A (en) * | 2015-08-11 | 2017-03-01 | 曹荣华 | Malleation capsule and its manufacture method |
| CN107157949A (en) * | 2017-06-09 | 2017-09-15 | 厦门普罗康客科技有限公司 | The method and its application of hard shell capsules inner seal |
-
2018
- 2018-04-16 CN CN201810339265.2A patent/CN108498479A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104039311A (en) * | 2011-11-17 | 2014-09-10 | 迈兰公司 | Liquid-filled hard gel capsule pharmaceutical formulations |
| CN103301086A (en) * | 2013-06-05 | 2013-09-18 | 绍兴康可胶囊有限公司 | Plant cellulose hard empty capsule preparation method |
| CN106466303A (en) * | 2015-08-11 | 2017-03-01 | 曹荣华 | Malleation capsule and its manufacture method |
| CN105663090A (en) * | 2016-01-07 | 2016-06-15 | 中山大学 | Slow release cubic liquid crystal liquid hard capsule and preparation method thereof |
| CN105498991A (en) * | 2016-01-20 | 2016-04-20 | 江苏力凡胶囊有限公司 | Hard capsule sealing liquid spraying device and method |
| CN205518268U (en) * | 2016-01-20 | 2016-08-31 | 江苏力凡胶囊有限公司 | Device of sealed liquid spraying of ebonite bag |
| CN107157949A (en) * | 2017-06-09 | 2017-09-15 | 厦门普罗康客科技有限公司 | The method and its application of hard shell capsules inner seal |
Non-Patent Citations (1)
| Title |
|---|
| 马家骅等: ""充液胶囊的研究进展"", 《中国中药杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641751A (en) * | 2020-09-25 | 2021-04-13 | 广州启键生物科技有限公司 | Filling hollow capsule of hydroxypropyl methylcellulose and algal polysaccharide |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180907 |