CN107157949A - The method and its application of hard shell capsules inner seal - Google Patents
The method and its application of hard shell capsules inner seal Download PDFInfo
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- CN107157949A CN107157949A CN201710433565.2A CN201710433565A CN107157949A CN 107157949 A CN107157949 A CN 107157949A CN 201710433565 A CN201710433565 A CN 201710433565A CN 107157949 A CN107157949 A CN 107157949A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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Abstract
The present invention relates to a kind of method and its application of hard shell capsules inner seal, method comprises the following steps：The capsule body of hard capsule case and capsule cap are separated, then in the inside stuffing material of capsule body；Sealing solution is sprayed in the inner surface of capsule cap, liquid film is formed；It will be filled with the capsule body of material and the capsule cap with liquid film be fit, then heat, seal intact to capsule.The method for the hard shell capsules inner seal that the present invention is provided; sealing solution is carried using inert gas; when the inner surface to capsule cap carries out the coating of sealing solution, protection of the inert gas to material in capsule can be achieved, so as to realize filling to the capsule of liquid and oxidizable material；And the method that the present invention is provided does not influence the outward appearance and size of capsule, can be widely applied to the encapsulated of fat-soluble medicine, can increase the bioavilability of medicine.
Description
Technical field
The present invention relates to capsule preparing technical field, and in particular to a kind of method and its application of hard shell capsules inner seal.
Background technology
Hard shell capsules (hard capsule) refer to a certain amount of medicinal substances extract dosing powder or auxiliary material uniform powder is made
End or particle, are filled in Capsules and are made, or medicinal powder direct packaging is made in Capsules.In modern Chinese herbal medicine
In preparation production, hard capsule is because technical process is relatively easy, convenient to take, rapid-action and can be effectively isolated the bad of medicine
The advantages of smell, it is widely used.However, existing hard shell capsules Canning Technique, due to complete sealing can not be realized,
So that oxidative degradation occurs in Long Term Contact air to the medicine of oxygen sensitive；The phenomenon of leakage then occurs in filling liquid,
So liquid can not be applied to or to the filling of the medicine of oxygen sensitive.
The content of the invention
For defect of the prior art, present invention aims at a kind of method for providing hard shell capsules inner seal and its should
With using inert gas carrying sealing solution, when the inner surface to capsule cap carries out the coating of sealing solution, to realize inert gas
Protection to material in capsule, so as to realize, and good leak tightness filling to the capsule of liquid and oxidizable material；And the present invention
The method of offer does not influence the outward appearance and size of capsule, can be widely applied to the encapsulated of fat-soluble medicine, can increase medicine
The bioavilability of thing, the further investigation development to capsule preparations is significant.
To achieve the above object, the technical scheme that provides of the present invention is：The invention provides a kind of hard shell capsules inner seal
Method, comprise the following steps：S1：The capsule body of hard capsule case and capsule cap are separated, then filled in the inside of capsule body
Material；S2：Sealing solution is sprayed in the inner surface of capsule cap, liquid film is formed；S3：It will be filled with the capsule body of material and with liquid
The capsule cap of body film is fit, then heats, and seals intact to capsule.It should be noted that in S3, heating is to allow sealing solution
In solvent volatilization, the adhesive in sealing solution is formed the sealing to capsule.
In the further embodiment of the present invention, in S3, it is heated to be：Fit capsule is placed in 30~40 DEG C of hot blast
Middle heating；Wherein, the wind speed of hot blast is 0.1~0.5m/s.
In the further embodiment of the present invention, in S1, the physical state of material is liquid and/or solid.
In the further embodiment of the present invention, S2 is specifically included：Sealing solution is carried using gas, is sprayed on after atomization
The inner surface of capsule cap, forms liquid film；Wherein, gas is nitrogen and/or inert gas.
In the further embodiment of the present invention, in S2, sealing solution includes adhesive and solvent, the quality point of adhesive
Number is 5%~70%.
In the further embodiment of the present invention, the raw material components of adhesive include PVP, and solvent is ethanol.
The present invention further embodiment in, the raw material components of adhesive by weight, including：PVP 20~
30 parts by weight, the parts by weight of Arabic gum 6~8, the parts by weight of hydroxypropyl methylcellulose 1~2, the parts by weight of gelatin 10~12, methyl-β-ring
The parts by weight of dextrin 15~20 and the parts by weight of agar 4~6.The binder materials component that the present invention is used, preferably 30 POVIDONE K 30 BP/USP 90,
CAS No：9003-39-8；Arabic gum CAS No：9000-01-05；Hydroxypropyl methylcellulose CAS No：9004-65-3；Gelatin
CAS No：9000-70-8；Methyl-B-cyclodextrin CAS No：128446-36-6 and agar CAS No：9008-18-0.
In the further embodiment of the present invention, the preparation method of adhesive comprises the following steps：By all raw materials
Component is well mixed, and obtains adhesive.
In the further embodiment of the present invention, the preparation method of sealing solution comprises the following steps：By adhesive and molten
Agent is well mixed, and obtains sealing solution.
The present invention also protects application of the method for above-mentioned hard shell capsules inner seal in hard shell capsules are prepared.
The technical scheme that the present invention is provided, with following beneficial effect：(1) the hard shell capsules inner seal that the present invention is provided
Method, before zoarium by spray etc. mode sealing solution is attached to inside capsule cap, after capsule is sealed, sealing solution solvent
The sealing to hard shell capsules is formed after drying, to realize the sealing of iquid capsule, leakage is prevented, while can also realize quick to oxygen
The solids content of sense for air isolation, in order to avoid storage during aoxidize；(2) present invention carries sealing using inert gas
Liquid, when the inner surface to capsule cap carries out the coating of sealing solution, can be achieved protection of the inert gas to material in capsule, method
Simply；(3) method for the hard shell capsules inner seal that the present invention is provided, outward appearance and size to capsule do not change, not interfered with
The follow-up packing of hard shell capsules；(4) method for the hard shell capsules inner seal that the present invention is provided, can be widely applied to substantial amounts of fat-soluble
Medicine, increases the bioavilability of medicine；(5) method for the hard shell capsules inner seal that the present invention is provided, it is possible to reduce compacting is soft
The use of a large amount of net glue during capsule, and avoid the disintegration time in the stomach that soft capsule causes capsule because of dehydration in Storage period
The appearance of the situation delayed.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obtain substantially, or recognized by the practice of the present invention.
Embodiment
Below in conjunction with the embodiment of the present invention, technical scheme is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme, therefore is intended only as example, and can not limit this hair with this
Bright protection domain.
Experimental method in following embodiments, is conventional method unless otherwise specified.Examination used in following embodiments
Material is tested, is to be commercially available from routine biochemistry reagent shop unless otherwise specified.Quantitative test in following examples,
Three repetition experiments are respectively provided with, data are the average value or mean+SD of three repetition experiments.The embodiment of the present invention is adopted
Binder materials component is：30 POVIDONE K 30 BP/USP 90, CAS No：9003-39-8；Arabic gum CAS No：9000-01-05；Hydroxyl
Third methylcellulose CAS No：9004-65-3；Gelatin CAS No：9000-70-8；Methyl-B-cyclodextrin CAS No：128446-
36-6 and agar CAS No：9008-18-0.
The present invention provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then in the inside liquid filling body and/or solid of capsule body
Material.
S2：Sealing solution is carried using nitrogen and/or inert gas, the inner surface of capsule cap is sprayed on after atomization, liquid is formed
Body film；Wherein, sealing solution includes adhesive and etoh solvent, and the mass fraction of adhesive is 5%~70%, the raw material of adhesive
Component includes PVP；The preparation method of sealing solution comprises the following steps：Adhesive and solvent are well mixed, sealed
Liquid.
Preferably, the raw material components of adhesive by weight, including：The parts by weight of PVP 20~30, Arabic gum 6~
8 parts by weight, the parts by weight of hydroxypropyl methylcellulose 1~2, the parts by weight of gelatin 10~12, the parts by weight of methyl-B-cyclodextrin 15~20 and fine jade
The parts by weight of fat 4~6；The preparation method of adhesive comprises the following steps：All raw material components are well mixed, bonded
Agent.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 30~40 DEG C, wind speed is 0.1~0.5m/s, the solvent volatilization into sealing solution is complete, capsule envelope
Mouth is intact.
The method of the hard shell capsules inner seal provided with reference to specific embodiment the present invention is described further.
Embodiment one
The present embodiment provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using nitrogen, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein, seal
Liquid includes adhesive PVP and etoh solvent, and the mass fraction of adhesive is 5%；The preparation method of sealing solution includes following step
Suddenly：Adhesive and solvent are well mixed, sealing solution is obtained.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 30 DEG C, wind speed is 0.1m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Embodiment two
The present embodiment provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using inert gas, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein,
Sealing solution includes adhesive PVP and etoh solvent, and the mass fraction of adhesive is 70%；The preparation method of sealing solution includes
Following steps：Adhesive and solvent are well mixed, sealing solution is obtained.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 40 DEG C, wind speed is 0.5m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Embodiment three
The present embodiment provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using nitrogen, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein, seal
Liquid includes adhesive PVP and etoh solvent, and the mass fraction of adhesive is 40%；The preparation method of sealing solution includes as follows
Step：Adhesive and solvent are well mixed, sealing solution is obtained.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 35 DEG C, wind speed is 0.3m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Example IV
The present embodiment provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using nitrogen, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein, seal
Liquid includes adhesive and etoh solvent, and the mass fraction of adhesive is 5%；The preparation method of sealing solution comprises the following steps：Will
Adhesive and solvent are well mixed, obtain sealing solution；
The raw material components of adhesive by weight, including：The parts by weight of PVP 20, the parts by weight of Arabic gum 8, hydroxypropyl first
The parts by weight of cellulose 1, the parts by weight of gelatin 12, the parts by weight of methyl-B-cyclodextrin 15 and the parts by weight of agar 6；The preparation side of adhesive
Method comprises the following steps：All raw material components are well mixed, adhesive is obtained.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 30 DEG C, wind speed is 0.1m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Embodiment five
The present embodiment provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using inert gas, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein,
Sealing solution includes adhesive and etoh solvent, and the mass fraction of adhesive is 70%；The preparation method of sealing solution includes following step
Suddenly：Adhesive and solvent are well mixed, sealing solution is obtained；
The raw material components of adhesive by weight, including：The parts by weight of PVP 30, the parts by weight of Arabic gum 6, hydroxypropyl first
The parts by weight of cellulose 2, the parts by weight of gelatin 10, the parts by weight of methyl-B-cyclodextrin 20 and the parts by weight of agar 4；The preparation side of adhesive
Method comprises the following steps：All raw material components are well mixed, adhesive is obtained.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 40 DEG C, wind speed is 0.5m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Embodiment six
The present embodiment provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using nitrogen, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein, seal
Liquid includes adhesive and etoh solvent, and the mass fraction of adhesive is 40%；The preparation method of sealing solution comprises the following steps：Will
Adhesive and solvent are well mixed, obtain sealing solution；
The raw material components of adhesive by weight, including：The parts by weight of PVP 25, the parts by weight of Arabic gum 7, hydroxypropyl first
The parts by weight of cellulose 1.5, the parts by weight of gelatin 11, the parts by weight of methyl-B-cyclodextrin 18 and the parts by weight of agar 5；The preparation of adhesive
Method comprises the following steps：All raw material components are well mixed, adhesive is obtained.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 35 DEG C, wind speed is 0.3m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Comparative example one
This comparative example provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using nitrogen, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein, seal
Liquid includes adhesive and etoh solvent, and the mass fraction of adhesive is 40%；The preparation method of sealing solution comprises the following steps：Will
Adhesive and solvent are well mixed, obtain sealing solution；
The raw material components of adhesive by weight, including：The parts by weight of PVP 25, the parts by weight of Arabic gum 7, hydroxypropyl first
The parts by weight of cellulose 1.5, the parts by weight of methyl-B-cyclodextrin 18 and the parts by weight of agar 5；The preparation method of adhesive includes following step
Suddenly：All raw material components are well mixed, adhesive is obtained.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 35 DEG C, wind speed is 0.3m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Comparative example two
This comparative example provides a kind of method of hard shell capsules inner seal, comprises the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then fat-soluble solids is filled in the inside of capsule body
Material.
S2：Sealing solution is carried using nitrogen, the inner surface of capsule cap is sprayed on after atomization, liquid film is formed；Wherein, seal
Liquid includes adhesive and etoh solvent, and the mass fraction of adhesive is 40%；The preparation method of sealing solution comprises the following steps：Will
Adhesive and solvent are well mixed, obtain sealing solution；
The raw material components of adhesive by weight, including：The parts by weight of PVP 25, the parts by weight of Arabic gum 7, hydroxypropyl first
The parts by weight of cellulose 1.5, the parts by weight of gelatin 11 and the parts by weight of agar 5；The preparation method of adhesive comprises the following steps：Will be all
Raw material components be well mixed, obtain adhesive.
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, be then placed in fit capsule
Heated in the hot blast that temperature is 35 DEG C, wind speed is 0.3m/s, the solvent volatilization into sealing solution is complete, and capsule sealing is intact.
Hard shell capsules after the embodiment of the present invention one is sealed to embodiment six, by function assessment experiment, come system evaluation, it is imitated
Really, the hard shell capsules and sealed using comparative example one, comparative example two are used as control.
1st, bioavilability
Bioavilability (bioavailability, F) is absorbed into whole body blood after referring to the outer approach administration of medicine intravascular
The relative quantity of liquid circulation.F=(A/D) × 100%；A is internal medicine total amount, and D is dosage.Influence bioavilability because
Element is more, includes size, crystal formation, the tight ness rating of filler, excipients and the production technology etc. of drug particles, bioavilability is
For evaluating the index of preparation degree of absorption.
Solid fat-soluble material (certain fat that the embodiment of the present invention one to embodiment six, comparative example one, comparative example two is used
Soluble drug) various property all sames, the closing hard shell capsules that will be obtained using different mouth-sealing methods carry out bioavilability inspection
Survey and (carried out according to the Chinese Pharmacopoeia pharmaceutical preparation human bioavailabilities of version 9011 in 2015 and Bioequivalence Test guideline
Determine), to characterize influence of the different methods to bioavilability.The life of the hard shell capsules for the fat-soluble medicine that pharmacy is sold
Thing availability is designated as 1, and the relative bioavailability for calculating the capsule of other obtained groups is recorded in table 1 below.
Influence of the table 1 to bioavilability
| Group | Relative bioavailability | Group | Relative bioavailability |
| Embodiment one | 1.265 | Example IV | 1.463 |
| Embodiment two | 1.257 | Embodiment five | 1.459 |
| Embodiment three | 1.279 | Embodiment six | 1.468 |
| Comparative example one | 1.035 | Comparative example two | 1.136 |
2nd, disintegration time
Disintegration refers to the physical dissolution process of pharmaceutical preparation before it is absorbed.Disintegration time refers under certain condition, ball, piece,
Capsule is disintegrated the time for being changed into particle, is to influence the principal element of oral drug bioavailability.
According to the inspection technique of 95 editions disintegration time limiteds of Chinese Pharmacopoeia, disintegration means that solid pharmaceutical preparation is all disintegrated within the inspection time limit
Leach or into particle, in addition to insoluble coating material or broken capsule shells, screen cloth should be passed through.The measure of disintegration time limited is using liter
Drop formula disintegration tester, conventional tablet should all be disintegrated in 15min, and hard capsule should all be disintegrated in 30min in capsule, soft
Capsule should all be disintegrated in 1h.
Solid fat-soluble material (certain fat that the embodiment of the present invention one to embodiment six, comparative example one, comparative example two is used
Soluble drug) various property all sames, the closing hard shell capsules that will be obtained using different mouth-sealing methods carry out disintegration time detection
(according to Chinese Pharmacopoeia, 95 editions are measured), to characterize influence of the different methods to disintegration time, determines obtained result such as
Shown in table 2 below, and the disintegration time of the hard shell capsules of the fat-soluble medicine of pharmacy's sale is 28.54min.
Influence of the table 2 to disintegration time
| Group | Disintegration time (min) | Group | Disintegration time (min) |
| Embodiment one | 25.28 | Example IV | 21.14 |
| Embodiment two | 25.16 | Embodiment five | 20.93 |
| Embodiment three | 25.03 | Embodiment six | 20.81 |
| Comparative example one | 28.15 | Comparative example two | 26.37 |
It should be noted that situation about being enumerated to embodiment six except above-described embodiment one, from other preparation methods
It is also feasible that parameter and raw material components, which are matched,.
The technical scheme that the present invention is provided, with following beneficial effect：(1) the hard shell capsules inner seal that the present invention is provided
Method, before zoarium by spray etc. mode sealing solution is attached to inside capsule cap, after capsule is sealed, sealing solution solvent
The sealing to hard shell capsules is formed after drying, to realize the sealing of iquid capsule, leakage is prevented, while can also realize quick to oxygen
The solids content of sense for air isolation, in order to avoid storage during aoxidize；(2) present invention carries sealing using inert gas
Liquid, when the inner surface to capsule cap carries out the coating of sealing solution, can be achieved protection of the inert gas to material in capsule, method
Simply；(3) method for the hard shell capsules inner seal that the present invention is provided, outward appearance and size to capsule do not change, not interfered with
The follow-up packing of hard shell capsules；(4) method for the hard shell capsules inner seal that the present invention is provided, can be widely applied to substantial amounts of fat-soluble
Medicine, increases the bioavilability of medicine；(5) method for the hard shell capsules inner seal that the present invention is provided, it is possible to reduce compacting is soft
The use of a large amount of net glue during capsule, and avoid the disintegration time in the stomach that soft capsule causes capsule because of dehydration in Storage period
The appearance of the situation delayed.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, otherwise illustrate in these embodiments
Part and relative step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely exemplary, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the invention, it is to be understood that term " first ", " second " are only used for describing purpose, and can not
It is interpreted as indicating or implies relative importance or the implicit quantity for indicating indicated technical characteristic.Thus, define " the
One ", one or more this feature can be expressed or be implicitly included to the feature of " second ".In the description of the invention,
" multiple " are meant that two or more, unless otherwise specifically defined.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme, it all should cover among protection scope of the present invention.
Claims (10)
1. a kind of method of hard shell capsules inner seal, it is characterised in that comprise the following steps：
S1：The capsule body of hard capsule case and capsule cap are separated, then in the inside stuffing material of the capsule body；
S2：Sealing solution is sprayed in the inner surface of the capsule cap, liquid film is formed；
S3：It will be filled with the capsule body of material and the capsule cap with liquid film be fit, then heat, seal intact to capsule.
2. the method for hard shell capsules inner seal according to claim 1, it is characterised in that：
It is described to be heated to be in the S3：Fit capsule is placed in 30~40 DEG C of hot blast and heated；Wherein, the hot blast
Wind speed is 0.1~0.5m/s.
3. the method for hard shell capsules inner seal according to claim 1, it is characterised in that：
In the S1, the physical state of the material is liquid and/or solid.
4. the method for hard shell capsules inner seal according to claim 1, it is characterised in that：
The S2 is specifically included：Sealing solution is carried using gas, the inner surface of the capsule cap is sprayed on after atomization, liquid is formed
Film；Wherein, the gas is nitrogen and/or inert gas.
5. the method for hard shell capsules inner seal according to claim 1, it is characterised in that：
In the S2, the sealing solution includes adhesive and solvent, and the mass fraction of described adhesive is 5%~70%.
6. the method for hard shell capsules inner seal according to claim 5, it is characterised in that：
The raw material components of described adhesive include PVP, and the solvent is ethanol.
7. the method for hard shell capsules inner seal according to claim 6, it is characterised in that
The raw material components of described adhesive by weight, including：The parts by weight of PVP 20~30, the weight of Arabic gum 6~8
Part, the parts by weight of hydroxypropyl methylcellulose 1~2, the parts by weight of gelatin 10~12, the parts by weight of methyl-B-cyclodextrin 15~20 and agar 4~
6 parts by weight.
8. the method for hard shell capsules inner seal according to claim 7, it is characterised in that
The preparation method of described adhesive comprises the following steps：All raw material components are well mixed, described adhesive is obtained.
9. the method for the hard shell capsules inner seal according to claim any one of 5-8, it is characterised in that
The preparation method of the sealing solution comprises the following steps：Described adhesive and the solvent are well mixed, obtain described
Sealing solution.
10. application of the method in hard shell capsules are prepared described in claim any one of 1-9.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108143724A (en) * | 2018-03-05 | 2018-06-12 | 上海祺宇生物科技有限公司 | A kind of high oxygen-impermeable plant hollow capsule and preparation method thereof |
| CN108261407A (en) * | 2018-03-05 | 2018-07-10 | 上海祺宇生物科技有限公司 | A kind of hypromellose Capsules for being used to suck medicament |
| CN108498479A (en) * | 2018-04-16 | 2018-09-07 | 绍兴康可胶囊有限公司 | A kind of filling liquid type empty hard capsule |
| CN115190796A (en) * | 2019-11-22 | 2022-10-14 | 卡尔·伟·曹 | Top liquid filling method and device for hard shell capsules |
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| CN104940161A (en) * | 2015-06-10 | 2015-09-30 | 绍兴康可胶囊有限公司 | Preparation method of sealing compound for hard hollow capsules |
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| EP0112183A2 (en) * | 1982-12-20 | 1984-06-27 | Warner-Lambert Company | A method of providing a seal on a capsule |
| EP0116743A1 (en) * | 1983-02-18 | 1984-08-29 | Warner-Lambert Company | Apparatus for and method of sealing capsules |
| CN1097596A (en) * | 1993-06-25 | 1995-01-25 | 潮州市药用胶囊厂 | Technology for producing gelatin hard capsule for containing liquid new preparation |
| CN1215322A (en) * | 1996-04-05 | 1999-04-28 | 沃尼尔·朗伯公司 | Process for encapsulation of caplets in a capsule and solid dosage forms obtainlable by such process |
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| CN1440740A (en) * | 2002-02-26 | 2003-09-10 | 潮州市药用胶囊厂 | Technological process of filling hard capsule with soft prepn |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108143724A (en) * | 2018-03-05 | 2018-06-12 | 上海祺宇生物科技有限公司 | A kind of high oxygen-impermeable plant hollow capsule and preparation method thereof |
| CN108261407A (en) * | 2018-03-05 | 2018-07-10 | 上海祺宇生物科技有限公司 | A kind of hypromellose Capsules for being used to suck medicament |
| CN108498479A (en) * | 2018-04-16 | 2018-09-07 | 绍兴康可胶囊有限公司 | A kind of filling liquid type empty hard capsule |
| CN115190796A (en) * | 2019-11-22 | 2022-10-14 | 卡尔·伟·曹 | Top liquid filling method and device for hard shell capsules |
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| CN107157949B (en) | 2021-01-15 |
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